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How Extreme Rainfall And Failing Dams Unleashed The Derna Flood Disaster, Ayman Mokhtar Nemnem, Ahad Hasan Tanim, Audrika Nahian, Sadik Khan, Erfan Goharian, Jasim Imran

Faculty Publications

On September 11, 2023, Storm Daniel unleashed unprecedented rainfall over the Wadi Derna watershed, triggering one of the most devastating floods in modern history, striking Derna, a coastal city in Libya. This study reconstructs the disaster using an integrated modeling approach that combines satellite imagery, hydrologic, hydraulic, and geotechnical simulations, machine learning, eyewitness accounts, and digital elevation data to assess the impact of cascading dam failures. Our findings reveal that the region’s dams, even if structurally sound, would have provided minimal protection against the extreme runoff. However, their failure unleashed a destructive surge wave, amplifying the disaster’s magnitude and devastation. …

How Extreme Rainfall And Failing Dams Unleashed The Derna Flood Disaster, Ayman Mokhtar Nemnem, Ahad Hasan Tanim, Audrika Nahian, Sadik Khan, Erfan Goharian, Jasim Imran

Faculty Publications

On September 11, 2023, Storm Daniel unleashed unprecedented rainfall over the Wadi Derna watershed, triggering one of the most devastating floods in modern history, striking Derna, a coastal city in Libya. This study reconstructs the disaster using an integrated modeling approach that combines satellite imagery, hydrologic, hydraulic, and geotechnical simulations, machine learning, eyewitness accounts, and digital elevation data to assess the impact of cascading dam failures. Our findings reveal that the region’s dams, even if structurally sound, would have provided minimal protection against the extreme runoff. However, their failure unleashed a destructive surge wave, amplifying the disaster’s magnitude and devastation. …

Nonnative Species Richness And Dominance Reveal Differing Support For Invasion Theory At A Continental Extent, Lily M. Thompson, William K. Annis, Stephen R. Midway, Julian D. Olden, Brandon K. Peoples

Faculty Publications

Aim: Empirical tests of conceptual hypotheses describing species invasions often differ depending on the spatial scale (spatial resolution and extent of study area) at which they were conducted. Some of this disparity may arise from tradeoffs in data quality necessitating the use of different indices of community invadedness among scales. Local-scale studies typically use fine-resolution, descriptive measures of community invadedness (‘dominance’, the proportion nonnative individuals) at limited spatial extents, while macroscale studies often aggregate datasets to cover large spatial extents but use coarser spatial resolution and less descriptive indices (nonnative species richness). We investigated the consequences of using different indices …

Association Of Nucleoside Reverse Transcriptase Inhibitor Use With Reduced Risk Of Alzheimer's Disease Risk, Joseph Magagnoli Ph.D., Ms, Meenakshi Ambati, Tammy H. Cummings, Joseph Nguyen, Claire C. Thomas, Vidya L. Ambati, S. Scott Sutton, Bradley D. Gelfand, Jayakrishna Ambati

Faculty Publications

INTRODUCTION

Inflammasome activation is implicated in Alzheimer's disease (AD). We previously demonstrated that nucleoside reverse transcriptase inhibitors (NRTIs), drugs approved to treat human immunodeficiency virus (HIV) and hepatitis B, also inhibit inflammasome activation.

METHODS

We evaluated the association between NRTI exposure and subsequent development of AD in the United States Veterans Health Administration over a 24-year period and in the MarketScan database over a 14-year period using propensity score-matched multivariate Cox hazards regression and Kaplan–Meier analyses.

RESULTS

We report that in humans, NRTI exposure was associated with a significantly lower incidence of AD in two of the largest health insurance …

Immigration Policy In The Second Trump Administration: Restriction, Removal, And The Limits Of Maga Nativism, Caroline R. Nagel

Faculty Publications

Donald Trump's three presidential campaigns have centred on promises to stop unauthorised immigration, whether by ‘building the wall’ or by enacting the largest mass deportation in American history. To deliver on these promises, Trump has appointed Stephen Miller—an anti-immigration hardliner who was responsible for the first Trump administration's draconian border policies – to a key White House position. Trump is often described as breaking from liberal-democratic norms; but when it comes to immigration policy, he is following a well-worn path by hiring Miller. This brief commentary places the Trump/Miller brand of anti-immigration politics in historical context, showing how anxieties over …

Immigration Policy In The Second Trump Administration: Restriction, Removal, And The Limits Of Maga Nativism, Caroline R. Nagel

Faculty Publications

Donald Trump's three presidential campaigns have centred on promises to stop unauthorised immigration, whether by ‘building the wall’ or by enacting the largest mass deportation in American history. To deliver on these promises, Trump has appointed Stephen Miller—an anti-immigration hardliner who was responsible for the first Trump administration's draconian border policies – to a key White House position. Trump is often described as breaking from liberal-democratic norms; but when it comes to immigration policy, he is following a well-worn path by hiring Miller. This brief commentary places the Trump/Miller brand of anti-immigration politics in historical context, showing how anxieties over …

Testing For Normality In Regression Models: Mistakes Abound (But May Not Matter), Stephen Midway, J. Wilson White

Faculty Publications

This study examines the misuse of normality tests in linear regression within ecology and biology, focusing on common misconceptions. A bibliometric review found that over 70% of ecology papers and 90% of biology papers incorrectly applied normality tests to raw data instead of model residuals. To assess the impact of this error, we simulated datasets with normal, interval, and skewed distributions across various sample and effect sizes. We compared statistical power between two approaches: testing the whole dataset for normality (incorrect) versus testing model residuals (correct) to determine whether to use a parametric (t-test) or nonparametric (Mann-Whitney U test) method. …

Feature Typology And L2 Proficiency Matter: L3 Acquisition Of Portuguese, Mila Tasseva-Kurktchieva, Danielle Fahey

Faculty Publications

To determine the source of transfer in third language acquisition (L3A), we tested the effects of grammatical feature typology and L2 Spanish proficiency on the comprehension and production of grammatical [gender] and [number] in the early stages of L3A of Portuguese. We distinguish between the two features based on their participation in the lexical-conceptual structure of the lemma and its interaction with the morpho-syntactic derivation. L1 English speakers were tested on their knowledge of the features in both their L2 and their L3 through a grammaticality judgment task and an elicited production task. Results show that L3 learners transfer only …

Displaced Decarbonization: Climate Necropolitics And The Contested Spatialities Of Green Hydrogen In Namibia, Meredith J. Deboom

Faculty Publications

Green hydrogen is often presented as a transformative solution to the dual challenges of decarbonization and economic development. This article applies the framework of climate necropolitics to interrogate the contested spatialities underlying such “win-win” narratives. It does so through an extended case study of Hyphen Hydrogen Energy, a $10 billion green hydrogen project planned for Lüderitz, Namibia. A remote town of 20,000 in a country with a $12 billion annual GDP, Lüderitz initially appears to be an unlikely host site for the “industrial fuel of the future.” To explain this outcome, I first illustrate how discordant socio-spatial projects—including European energy …

Learning From Indigenous Knowledge And Research, Rob Morrison

Faculty Publications

The goal of this sabbatical research is to learn more about non-Western ways of knowing and learning (epistemologies) and to become a more effective culturally responsive teacher. I investigated how Indigenous Knowledge and research practices can enrich current definitions and practices of Information Literacy and integrate them into the research process. Information Literacy is part of a larger and more complex research process that involves connecting researchers’ questions and purpose with literature reviews and the resulting new knowledge.

I am continuing my research journey that started with my dissertation work on Culturally Relevant Information Literacy and Critical Information Literacy (CIL). …

A Skill Assessment Framework For The Fisheries And Marine Ecosystem Model Intercomparison Project, Nina Rynne, Camilla Novaglio, Julia Blanchard, Daniele Bianchi, Villy Christensen, Marta Coll, Jerome Guiet, Jeroen Steenbeek, Andrea Bryndum-Buchholz, Tyler D. Eddy, Cheryl Harrison, Olivier Maury, Kelly Ortega-Cisneros, Colleen M. Petrik, Derek P. Tittensor, Ryan F. Heneghan

Faculty Publications

Understanding climate change impacts on global marine ecosystems and fisheries requires complex marine ecosystem models, forced by global climate projections, that can robustly detect and project changes. The Fisheries and Marine Ecosystems Model Intercomparison Project (FishMIP) uses an ensemble modeling approach to fill this crucial gap. Yet FishMIP does not have a standardised skill assessment framework to quantify the ability of member models to reproduce past observations and to guide model improvement. In this study, we apply a comprehensive model skill assessment framework to a subset of global FishMIP models that produce historical fisheries catches. We consider a suite of …

Endothelial Dysfunction Promotes Age-Related Reorganization Of Collagen Fibers And Alters Aortic Biomechanics In Mice, Liya Du, Jeffrey Rodgers, Nazli Gharraee, Olivia Gary, Tarek Shazly, John F. Eberth, Susan M. Lessner

Faculty Publications

Endothelial dysfunction, defined as a reduction in the bioavailability of nitric oxide (NO), is a risk factor for the occurrence and progression of various vascular diseases. This study investigates the effect of endothelial dysfunction on age-related changes in aortic extracellular matrix (ECM) microstructure and the relationship between microstructural adaptation and the mechanical response. Here, we used groups of NOS3 knockout (KO), NOS3 heterozygotes (Het), and wild-type (WT) B6 mice (controls) to study changes in hemodynamic parameters, collagen fiber organization, and both active and passive aortic mechanics using biaxial pressure myography over a time course from 1.5 to 12 mo. Our …

Endothelial Dysfunction Promotes Age-Related Reorganization Of Collagen Fibers And Alters Aortic Biomechanics In Mice, Liya Du, Jeffrey Rodgers, Nazli Gharraee, Olivia Gary, Tarek Shazly, John F. Eberth, Susan M. Lessner

Faculty Publications

Endothelial dysfunction, defined as a reduction in the bioavailability of nitric oxide (NO), is a risk factor for the occurrence and progression of various vascular diseases. This study investigates the effect of endothelial dysfunction on age-related changes in aortic extracellular matrix (ECM) microstructure and the relationship between microstructural adaptation and the mechanical response. Here, we used groups of NOS3 knockout (KO), NOS3 heterozygotes (Het), and wild-type (WT) B6 mice (controls) to study changes in hemodynamic parameters, collagen fiber organization, and both active and passive aortic mechanics using biaxial pressure myography over a time course from 1.5 to 12 mo. Our …

Shear-Thinning Hydrogel For Delayed Delivery Of A Small Molecule Metalloproteinase Inhibitor Attenuates Myocardial Infarction Remodeling, Joshua E. Mealy, William M. Torres, Lisa A. Freeburg, Shayne C. Barlow, Alison A. Whalen, Chima V. Maduka, Tarek Shazly, Jason A. Burdick, Francis G. Spinale

Faculty Publications

No abstract provided.

Mirrors For Pacific Islander Children: Teaching Resilience Through Culturally Adapted Bibliotherapy, Isabel Medina Hull, Elizabeth Cutrer, Paul H. Ricks, G. E. Kawika Allen, Kendra M. Hall-Kenyon, Lorena Seu, Kristopher J. Urbina, Melia Fonoimoana Garrett

Faculty Publications

Pacific Islander youth face disproportionately high rates of suicide and mental health challenges, yet culturally appropriate interventions remain scarce. This study investigated whether culturally adapted bibliotherapy could effectively promote resilience in American Samoan children by incorporating culturally relevant stories and coping strategies. Through collaboration with on-island Samoan cultural brokers, we developed and implemented culturally adapted stories and lessons designed to resonate with the experiences of children in American Samoa. The study employed a mixed-methods approach with 34 American Samoan children aged 5–13 years, using observations, adapted card sorts, and forced-choice procedures to measure responses to the intervention. The results demonstrated …

Msbzip55 Regulates Salinity Tolerance By Modulating Melatonin Biosynthesis In Alfalfa, Tingting Wang, Jiaqi Yang, Jiamin Cao, Qi Zhang, Huayue Liu, Peng Li, Yizhi Huang, Wenwu Qian, Xiaojing Bi, Hui Wang, Yunwei Zhang

Faculty Publications

No abstract provided.

Comparison Of Deep Learning And Traditional Machine Learning Models For Predicting Mild Cognitive Impairment Using Plasma Proteomic Biomarkers, Kesheng Wang Phd, Ma, Bs, Donald A. Adjeroh, Wei Fang, Suzy M. Walter, Danqing Xiao, Ubolrat Piamjariyakul, Chun Xu

Faculty Publications

Mild cognitive impairment (MCI) is a clinical condition characterized by a decline in cognitive ability and progression of cognitive impairment. It is often considered a transitional stage between normal aging and Alzheimer’s disease (AD). This study aimed to compare deep learning (DL) and traditional machine learning (ML) methods in predicting MCI using plasma proteomic biomarkers. A total of 239 adults were selected from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) cohort along with a pool of 146 plasma proteomic biomarkers. We evaluated seven traditional ML models (support vector machines (SVMs), logistic regression (LR), naïve Bayes (NB), random forest (RF), k-nearest neighbor …

Enhancing Mucus Flow And Clearance By Grafting Zwitterionic Hydrogel Films To Luminal Surfaces, Ryan Horne, Caleb Escudero, Morgan Ellerman, C. Allan Guymon, Marlan Hansen

Faculty Publications

Objective

To determine the effects of zwitterionic hydrogel films on mucus contact angles, flow, and stasis with respect to medical polymer surfaces, both flat and tubular.

Methods

A zwitterionic hydrogel thin film was photografted onto medical rubber surfaces and compared against non-zwitterionic hydrogel thin films and untreated surfaces to determine its impact on mucus contact angles, mucus flow on sheets and tubes, and mucus plugging.

Results

Zwitterionic and conventional hydrogel films significantly reduce the mucus contact angles and the tilt required to initiate mucus flow on sheets and in tubular systems. Preliminary experiments show that these films may also shorten …

Nucleoredoxin Regulates Wnt Signaling During Pituitary Stem Cell Differentiation, Michelle L. Brinkmeier, Leonard Y M Cheung, Sean P. O'Connell, Diana K. Gutierrez, Eve C. Rhoads, Sally A. Camper, Shannon W. Davis

Faculty Publications

Nucleoredoxin (Nxn) encodes a multi-functional enzyme with oxidoreductase activity that regulates many different signaling pathways and cellular processes in a redox-dependent manner. Rare NXN mutations are reported in individuals with recessive Robinow syndrome, which involves mesomelic skeletal dysplasia, short stature, craniofacial dysmorphisms, and incompletely penetrant heart and palate defects. Here we report that Nxn is expressed in the ventral diencephalon and developing pituitary gland, and that Nxn deficient mice have pituitary dysmorphology and craniofacial abnormalities that include defects in the skull base and cleft palate. Nxn mutant mice exhibit reduced WNT signaling and reduced differentiation of pituitary stem …

Disruption Of G3bp1 Granules Promotes Mammalian Cns And Pns Axon Regeneration, Pabitra K. Sahoo, Manasi Agrawal, Nicholas Hanovice, Patricia J. Ward, Meghal Desai, Terika P. Smith, Hao Min Sima, Jennifer N. Dulin, Lauren S. Vaughn, Mark H. Tuszynski, Kristy Welshhans, Larry I. Benowitz, Arthur W. English, John D. Houle, Jeffery L. Twiss

Faculty Publications

Depletion or inhibition of core stress granule proteins, G3BP1 in mammals and TIAR-2 in Caenorhabditis elegans, increases the growth of spontaneously regenerating axons. Inhibition of G3BP1 by expression of its acidic or “B-domain” accelerates axon regeneration after nerve injury, bringing a potential therapeutic strategy for peripheral nerve repair. Here, we asked whether G3BP1 inhibition is a viable strategy to promote regeneration in injured mammalian central nervous system (CNS) where axons do not regenerate spontaneously. G3BP1 B-domain expression was found to promote axon regeneration in the transected spinal cord provided with a permissive peripheral nerve graft (PNG) as well as in …

Disruption Of G3bp1 Granules Promotes Mammalian Cns And Pns Axon Regeneration, Pabitra K. Sahoo, Manasi Agrawal, Nicholas Hanovice, Patricia J. Ward, Meghal Desai, Terika P. Smith, Haomin Sima, Jennifer N. Dulin, Lauren S. Vaughn, Mark H. Tuszynski, Kristy Welshhans, Larry I. Benowitz, Arthur W. English, John D. Houle, Jeffery L. Twiss

Faculty Publications

Depletion or inhibition of core stress granule proteins, G3BP1 in mammals and TIAR-2 in Caenorhabditis elegans, increases the growth of spontaneously regenerating axons. Inhibition of G3BP1 by expression of its acidic or “B-domain” accelerates axon regeneration after nerve injury, bringing a potential therapeutic strategy for peripheral nerve repair. Here, we asked whether G3BP1 inhibition is a viable strategy to promote regeneration in injured mammalian central nervous system (CNS) where axons do not regenerate spontaneously. G3BP1 B-domain expression was found to promote axon regeneration in the transected spinal cord provided with a permissive peripheral nerve graft (PNG) as well as …

Developing A Southern Ocean Marine Ecosystem Model Ensemble To Assess Climate Risks And Uncertainties, Kieran Murphy, Denisse Fierro-Arcos, Tyler Rohr, David Green, Camilla Novaglio, Katherine Baker, Kelly Ortega-Cisneros, Tyler D. Eddy, Cheryl S. Harrison, Simeon L. Hill, Patrick Eskuche-Keith, Camila Cataldo-Mendez, Colleen M. Petrik, Matthew Pinkerton, Paul Spence, Ilaria Stollberg, Roshni C. Subramaniam, Rowan Trebilco, Vivitskaia Tulloch, Juliano Palacios-Abrantes, Sophie Bestley, Daniele Bianchi, Philip Boyd, Pearse J. Buchanan, Andrea Bryndum-Buchholz, Marta Coll, Stuart Corney, Samik Datta, Jason D. Everett, Romain Forestier, Elizabeth A. Fulton, Vianney Guibourd De Luzinais, Ryan Heneghan

Faculty Publications

Climate change could irreversibly modify Southern Ocean ecosystems. Marine ecosystem model (MEM) ensembles can assist policy making by projecting future changes and allowing the evaluation and assessment of alternative management approaches. However, projected changes in total consumer biomass from the Fisheries and Marine Ecosystem Model Intercomparison Project (FishMIP) global MEM ensemble highlight an uncertain future for the Southern Ocean, indicating the need for a region-specific ensemble. A large source of model uncertainty originates from the Earth system models used to force FishMIP models, particularly future changes to lower trophic level biomass and sea-ice coverage. To build confidence in regional MEMs …

Global And Regional Marine Ecosystem Models Reveal Key Uncertainties In Climate Change Projections, Tyler D. Eddy, Ryan F. Heneghan, Andrea Bryndum-Buchholz, Elizabeth A. Fulton, Cheryl S. Harrison, Derek P. Tittensor, Heike K. Lotze, Kelly Ortega-Cisneros, Camilla Novaglio, Daniele Bianchi, Matthias Büchner, Catherine Bulman, William W.L. Cheung, Villy Christensen, Marta Coll, Jason D. Everett, Denisse Fierro-Arcos, Eric D. Galbraith, Didier Gascuel, Jerome Guiet, Steve Mackinson, Olivier Maury, Susa Niiranen, Ricardo Oliveros-Ramos, Juliano Palacios-Abrantes, Chiara Piroddi, Hubert Du Pontavice, Jonathan Reum, Anthony J. Richardson, Jacob Schewe, Lynne Shannon, Yunne Jai Shin, Jeroen Steenbeek

Faculty Publications

Climate change is affecting ocean temperature, acidity, currents, and primary production, causing shifts in species distributions, marine ecosystems, and ultimately fisheries. Earth system models simulate climate change impacts on physical and biogeochemical properties of future oceans under varying emissions scenarios. Coupling these simulations with an ensemble of global marine ecosystem models has indicated broad decreases of fish biomass with warming. However, regional details of these impacts remain much more uncertain. Here, we employ CMIP5 and CMIP6 climate change impact projections using two Earth system models coupled with four regional and nine global marine ecosystem models in 10 ocean regions to …

Modulators Of Energy Expenditure Accuracy In Adults With Overweight Or Obesity: E-Mechanic Secondary Analyses, Rachel Matthews, Christoph Höchsmann, Melissa L. Erickson, James L. Dorling, Guillaume Spielmann, Neil M. Johannsen, Timothy S. Church, Corby K. Martin

Faculty Publications

Purpose American College of Sports Medicine (ACSM) metabolic equations are used to estimate energy expenditure (EE) of physical activity and prescribe aerobic exercise to meet EE requirements. Limited evidence supports their accuracy in sedentary adults with overweight or obesity during controlled exercise interventions. The purpose of this study was to compare EE estimated by the ACSM walking equation versus EE measured by indirect calorimetry during a 24-wk aerobic exercise intervention, and identify potential modulators for their accuracy. Methods Data from the exercising groups (8 or 20 kcal·kg body weight-1·wk-1) of the E-MECHANIC study were utilized in this ancillary analysis (N …

Race, The Academy, And The Constitution Of The War On Drugs, Bennett Capers, Jeffrey Bellin

Faculty Publications

The war on drugs is widely viewed as a policy failure. Despite massive government intrusions on personal liberty, drug addiction, overdoses, and drug-related violence have only increased since the war was declared in 1971. David Pozen’s new book, The Constitution of the War on Drugs, reveals a constitutional failure as well. Pozen chronicles a host of constitutional arguments that American litigants deployed to protect a “right” to use drugs with surprising, if fleeting, success. Pozen asks what might have been, exploring why the courts backtracked and effectively removed the Constitution as a meaningful obstacle to drug prohibitions.

This Review …

Urbanization Impacts Dissolved Organic Matter Concentration And Quality In A Southeastern United States Watershed, Gwendolyn M. Hopper, Erik M. Smith, Jade Dormoy-Boulanger, Claudia R. Benitez-Nelson

Faculty Publications

Blackwater rivers are named due to their exceptionally high concentrations of chromophoric dissolved organic matter (CDOM). They are the predominant lotic ecosystem in the United States Southeastern Coastal Plain, a region experiencing some of the nation’s highest rates of development. This study assessed variability in DOM concentration and composition across forested to urbanized blackwater systems in coastal South Carolina, U.S. Dissolved organic carbon and nutrient concentrations as well as absorbance and fluorescence optical properties reveal that urban sites have lower concentrations, elemental ratios, and less complex DOM. In contrast, forested blackwater sites have concentrations an order of magnitude higher, elevated …

Impact Of Voluntary Exercise On Systemic Inflammation In A 2? Hit Model Of Heart Failure With Preserved Ejection Fraction, Heather Quiriarte, Eunhan Cho, Youyoung Kim, Jake E. Doiron, Gregory Davis, James Stampley, Robert C. Noland, Zhen Li, Sanjiv J. Shah, Brian A. Irving, Guillaume Spielmann, David J. Lefer, Timothy D. Allerton

Faculty Publications

No abstract provided.

A Data-Driven Approach To Enhance The Prediction Of Bacteria–Metabolite Interactions In The Human Gut Microbiome Using Enzyme Encodings And Metabolite Structural Embeddings, Gopal Srivastava, Michal Brylinski

Faculty Publications

Background: The human gut microbiome is critical for host health by facilitating essential metabolic processes. Our study presents a data-driven analysis across 312 bacterial species and 154 unique metabolites to enhance the understanding of underlying metabolic processes in gut bacteria. The focus of the study was to create a strategy to generate a theoretical (negative) set for binary classification models to predict the consumption and production of metabolites in the human gut microbiome. Results: Our models achieved median balanced accuracies of 0.74 for consumption predictions and 0.95 for production predictions, highlighting the effectiveness of this approach in generating reliable negative …

Butterfly Species Vary In Sex-Specific Sodium Accumulation From Larval Diets, Luis Y. Santiago-Rosario, Alexander M. Shephard, Emilie Snell-Rood, Achim D. Herrmann, Kyle E. Harms

Faculty Publications

Sodium is essential for animals, and its heterogeneous distribution can cause a range of phenomena, from sodium-seeking behaviours to impacting their performance. Although sodium content in soils and plants is relatively well documented, data for higher trophic levels are limited. Knowledge of the variation in sodium in lower trophic levels could have implications for understanding the behaviour and physiology of species at higher levels. We investigated the variation in tissue sodium concentration between males and females of four butterfly species. Puddling behaviour of Lepidoptera suggests sodium needs of males are generally greater than females, thus, we predicted males would accumulate …

Increased Expression Of The Small Lysosomal Gene Svip In The Drosophila Gut Suppresses Pathophysiological Features Associated With A High-Fat Diet, Brennan M. Mercola, Tatiana V. Villalobos, Jocelyn E. Wood, Ankita Basu, Alyssa E. Johnson

Faculty Publications

Lysosomes are digestive organelles that are crucial for nutrient sensing and metabolism. Lysosome impairment is linked to a broad spectrum of metabolic disorders, underscoring their importance to human health. Thus, lysosomes are an attractive target for metabolic disease therapies. In previous work, we discovered a novel class of tubular lysosomes that are morphologically and functionally distinct from traditionally described vesicular lysosomes. Tubular lysosomes are present in multiple tissues, are broadly conserved from invertebrates to mammals, are more proficient at degrading autophagic cargo than vesicular lysosomes, and delay signs of tissue aging when induced ectopically. Thus, triggering tubular lysosome formation presents …