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Articles 9241 - 9270 of 35658
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A Novel Fibroblast Growth Factor 1 Variant Reverses Nonalcoholic Fatty Liver Disease In Type 2 Diabetes., Qian Lin
Electronic Theses and Dissertations
Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disorder and is strongly associated with type 2 diabetes (T2D). Our recently engineered FGF1 partial agonist, carrying triple mutations (FGF1△HBS) exhibits greatly reduced proliferative potential, while preserving the full metabolic activity of wild-type FGF1. This study tests the preventive and therapeutic effects of FGF1△HBS on NAFLD in db/db T2D and explores potential mechanisms. The results showed that administration of FGF1△HBS to 2-month-old db/db mice for 2 months constantly lowered blood glucose levels, improved insulin sensitivity, and lowered liver weight, lipid deposition, and …
Accuracy Differences Between Interview Formats : Examining Factors That May Influence Metamemory Utilization., Robin F. Hopkins
Accuracy Differences Between Interview Formats : Examining Factors That May Influence Metamemory Utilization., Robin F. Hopkins
Electronic Theses and Dissertations
Eyewitnesses are important for criminal investigations. When interviewing witnesses, police first ask witnesses to describe what they observed. This initial statement is a free narrative (FN) and is usually highly accurate. Next, police ask follow-up questions (FQs), which generate additional information but often at the cost of accuracy. This dissertation aims to examine factors that may contribute to the effect of interview format on accuracy and whether FQ instructions change detail quality provided in follow-up question responses (FQRs). Additionally, individual differences in responding to FQ instructions were explored. Subjects watched a movie clip depicting a crime. Next, subjects filled out …
The Influence Of High-Performance Work Systems And Intangible Strategic Resources On The Entrepreneurial Orientation-Firm Performance Relationship., Shankar Naskar
Electronic Theses and Dissertations
The entrepreneurship literature indicates that entrepreneurially oriented firms perform better and grow faster than firms that are conservatively oriented. Firms with an entrepreneurial orientation (EO) jointly exhibit risk-taking, innovative and proactive behaviors. The EO-firm performance relationship is a well-established one. However, scholars have bemoaned the lack of focus on internal organizational factors that may influence or affect the nature of the relationship. My dissertation uses the framework of the resource-based theory of the firm to argue that the influence of EO on performance is contingent on the resources and the internal organizing context (organizing capability) of a firm. The resource-based …
Bayesian Analytical Approaches For Metabolomics : A Novel Method For Molecular Structure-Informed Metabolite Interaction Modeling, A Novel Diagnostic Model For Differentiating Myocardial Infarction Type, And Approaches For Compound Identification Given Mass Spectrometry Data., Patrick J. Trainor
Electronic Theses and Dissertations
Metabolomics, the study of small molecules in biological systems, has enjoyed great success in enabling researchers to examine disease-associated metabolic dysregulation and has been utilized for the discovery biomarkers of disease and phenotypic states. In spite of recent technological advances in the analytical platforms utilized in metabolomics and the proliferation of tools for the analysis of metabolomics data, significant challenges in metabolomics data analyses remain. In this dissertation, we present three of these challenges and Bayesian methodological solutions for each. In the first part we develop a new methodology to serve a basis for making higher order inferences in metabolomics, …
An Examination Of Box Office Relationship Quality And Relationship Selling In Division I College Athletics., James F. Weiner
An Examination Of Box Office Relationship Quality And Relationship Selling In Division I College Athletics., James F. Weiner
Electronic Theses and Dissertations
College athletics departments have experienced unprecedented growth. However, expenses have risen even faster (Fulks, 2016), and university athletics departments have relied on increased subsidies from host institutions and donations to make ends meet (Fulks, 2016). The root cause behind much of the revenue increases have been credited to large multimedia and broadcast contracts, which guarantee substantial income for decade-long terms (Sherman, 2016). Such agreements leave little room for individual growth, leaving ticket sales as one of the few controllable revenues to which a school could manipulate their own bottom line and increase profitability. Further investigation into box office sales trends …
Material-Process-Property Relationships Of 17-4 Stainless Steel Fabricated By Laser-Powder Bed Fusion Followed By Hot Isostatic Pressing., Harish Irrinki
Material-Process-Property Relationships Of 17-4 Stainless Steel Fabricated By Laser-Powder Bed Fusion Followed By Hot Isostatic Pressing., Harish Irrinki
Electronic Theses and Dissertations
17-4 PH stainless steel is commonly used in medical, tooling, automotive, chemical and aerospace industries due to its excellent strength and corrosion properties. Additive manufacturing processes such as laser-powder bed fusion (L-PBF) have gained attention and importance due to the potential to produce complex-shaped three-dimensional parts for various industries. In order to manufacture three-dimensional components from 17-4 PH stainless steel powder using L-PBF, it is critical for design and manufacturing engineers to have an awareness of various material options and corresponding processing and post-processing conditions to obtain useful mechanical properties from the process. The goal of this dissertation is to …
Deciphering The Role Of Human Arylamine N-Acetyltransferase 1 (Nat1) In Breast Cancer Cell Metabolism Using A Systems Biology Approach., Samantha Marie Carlisle
Deciphering The Role Of Human Arylamine N-Acetyltransferase 1 (Nat1) In Breast Cancer Cell Metabolism Using A Systems Biology Approach., Samantha Marie Carlisle
Electronic Theses and Dissertations
Background: Human arylamine N-acetyltransferase 1 (NAT1) is a phase II xenobiotic metabolizing enzyme found in almost all tissues. NAT1 can additionally hydrolyze acetyl-coenzyme A (acetyl-CoA) in the absence of an arylamine substrate. NAT1 expression varies inter-individually and is elevated in several cancers including estrogen receptor positive (ER+) breast cancers. Additionally, multiple studies have shown the knockdown of NAT1, by both small molecule inhibition and siRNA methods, in breast cancer cells leads to decreased invasive ability and proliferation and decreased anchorage-independent colony formation. However, the exact mechanism by which NAT1 expression affects cancer risk and progression remains unclear. Additionally, consequences …
An Examination Of Pbis Implementation Fidelity And Student Outcomes In An Urban School District., C. Angelique Scherer
An Examination Of Pbis Implementation Fidelity And Student Outcomes In An Urban School District., C. Angelique Scherer
Electronic Theses and Dissertations
The purpose of this study was to examine Positive Behavior Interventions and Supports (PBIS) implementation fidelity and student outcomes for secondary schools in a large, urban school district. The state department of education placed the district under corrective action due to disproportionate suspension practices. In response to the corrective action, district administration required 24 schools to participate in PBIS training. This study is an analysis of PBIS implementation fidelity data, office discipline referrals, suspensions, and standardized test scores to determine if there were significant differences after PBIS implementation. I employed the repeated measures analysis of variance (ANOVA) to examine outcomes …
Unfolded Protein Response Pathways In Skeletal Muscle Homeostasis., Kyle R. Bohnert
Unfolded Protein Response Pathways In Skeletal Muscle Homeostasis., Kyle R. Bohnert
Electronic Theses and Dissertations
Skeletal muscle mass, contractile properties, and metabolic function are regulated through the coordinated activation of multiple intracellular signaling pathways and genetic reprogramming. The endoplasmic reticulum (ER) plays a pivotal role in protein folding and calcium homeostasis in many cell types, including skeletal muscle. Disruption of calcium levels or accumulation of misfolded proteins in the ER lumen leads to stress, which results in the activation of a signaling network called the unfolded protein response (UPR). Further, recent studies have suggested that in certain conditions, UPR pathways can be activated independent of ER stress. However, the role of ER stress and the …
Art Theft, Art Vandalism, And Guardianship In U.S. Art Institutions., Katharine L. Salomon
Art Theft, Art Vandalism, And Guardianship In U.S. Art Institutions., Katharine L. Salomon
Electronic Theses and Dissertations
Art crime scholars and art world professionals constantly grapple with determining the most effective methods by which to reduce and prevent victimization by art thieves and art vandals. Despite the numerous accounts of this form of criminality, there is a dearth of empirical studies focused on the security and care of art collections. Using Routine Activities Theory to guide the research, the present study explores the relationship between social and physical guardianship practices and the prevalence of art theft and art vandalism using questionnaire data collected from 111 American art museums and art galleries. The results indicate an overwhelming lack …
Investigating The Impact Of Nrmt1 Cancer Mutants On Catalytic Specificity And The Dna Damage Response., Kaitlyn Marie Shields
Investigating The Impact Of Nrmt1 Cancer Mutants On Catalytic Specificity And The Dna Damage Response., Kaitlyn Marie Shields
Electronic Theses and Dissertations
Protein methylation is an established and critical posttranslational modification controlling multiple cellular events. Alterations in protein methylation have been implicated in many diseases, including cancer. My work focused on the N-terminal trimethylase NRMT1 and the N-terminal monomethylase NRMT2. Previous work proposed that NRMT2 assists NRMT1 by priming its substrates for trimethylation. Importantly, NRMT1 mutations have been found in cancers, and loss of NRMT1 has been shown to promote oncogenic phenotypes in cancer cells. Together, this suggests that altered activities of NRMT1/2 may play a role in cancer progression. Although NRMT1/2 are 50% identical, they differ in key aromatic residues in …
Microstructure And Mechanical Properties Of Selective Laser Melted Superalloy Inconel 625., Md Ashabul Anam
Microstructure And Mechanical Properties Of Selective Laser Melted Superalloy Inconel 625., Md Ashabul Anam
Electronic Theses and Dissertations
Selective Laser Melting (SLM), a powder based Additive Manufacturing (AM) process, has gained considerable attention in the aerospace, biomedical and automotive industries due to its many potential benefits, such as, capability of fabricating complex three-dimensional components, shortened design to product time, reduction in process steps, component mass reduction and material flexibility. This process uses metallic powder and is capable of fabricating complex structures with excellent microstructure which make SLM not only an improvement over other manufacturing processes but also innovative material processing technology. Inconel 625, a nickel-based super alloy is widely popular in aerospace, chemical and nuclear industries. This alloy …
Weight Stigma And Motivation To Exercise : Exploring Associations And Constructs From The Basic Needs Theory., Stephanie R. Mcdonough
Weight Stigma And Motivation To Exercise : Exploring Associations And Constructs From The Basic Needs Theory., Stephanie R. Mcdonough
Electronic Theses and Dissertations
Social influences, such as weight stigma, perpetuate rates of overweight and obesity, as well as contribute to poor physical and psychological health. It has been postulated that weight stigma negatively affects motivation to exercise, though the literature is mixed and underlying mechanisms of action are not well conceived. The present study aimed to: (1) explore the relationship between frequency of experienced weight stigma and exercise motivation and behavior (2) assess how frequency of experienced weight stigma might differ based on participant characteristics such as body weight and (3) consider unique associations between frequency of personal experiences with weight-based stigma, exercise …
Effects Of Context And Individual Differences On Memory For Prior Remembering., Marcus L. Leppanen
Effects Of Context And Individual Differences On Memory For Prior Remembering., Marcus L. Leppanen
Electronic Theses and Dissertations
Though people often remember experiences from their lives, they are also able to remember whether a memory has previously been retrieved, which is known as memory for prior remembering. Frequent failures of memory for prior remembering can have negative consequences on how people perceive their own cognitive health. The recurrence of traumatic memory retrieval can be interpreted as a consequence of intrusive memory for prior remembering. This dissertation was conducted to improve our understanding of the factors that influence the efficacy of memory for prior remembering. The two factors that were investigated were context change and individual differences. Participants ( …
Organization And Development Of Cholinergic Input To The Mouse Visual Thalamus., Guela Sokhadze
Organization And Development Of Cholinergic Input To The Mouse Visual Thalamus., Guela Sokhadze
Electronic Theses and Dissertations
Cholinergic signaling plays a vital role in modulating the flow of sensory information through thalamic circuits in a state-dependent manner. In the dorsal lateral geniculate nucleus (dLGN), the thalamic visual relay, release of acetylcholine (ACh) contributes to enhanced thalamocortical transfer of retinal signal during behavioral states of arousal, wakefulness, and sleep/wake transitions. Moreover, ACh modulates activity of the thalamic reticular nucleus (TRN), a structure which provides inhibitory input to dLGN. While several cholinergic nuclei have been shown to innervate dLGN and TRN, it is unclear how projections from each area are organized. Furthermore, little is known of how or when …
Alpha-Amino Methylation And Acetylation Are Novel Regulators Of Myl9 Function., Christopher David Nevitt
Alpha-Amino Methylation And Acetylation Are Novel Regulators Of Myl9 Function., Christopher David Nevitt
Electronic Theses and Dissertations
Dysregulation of alpha-amino post-translational modifications (Nα-PTMs) is found in multiple cancers and developmental disorders. However, the exact roles Nα-PTMs play in regulating protein function remain poorly understood. I sought to clarify the role of Nα-methylation and Nα-acetylation in the regulation of Myosin Regulatory Light Chain 9 (MYL9). MYL9 is a key cytoskeletal regulator and transcription factor and is the first protein confirmed to undergo both Nα-methylation and Nα-acetylation. Through this work I revealed novel regulatory features of MYL9, while also presenting a framework by which to understand the coordinated regulation of proteins by Nα-methylation and Nα-acetylation. Nα-PTM selective mutants of …
Plasma Based Synthesis And Surface Modification Of Graphene., Rong Zhao
Plasma Based Synthesis And Surface Modification Of Graphene., Rong Zhao
Electronic Theses and Dissertations
Graphene, an atom thick layer of carbon, has attracted intense scientific interest due to its exceptional electrical, mechanical and chemical properties. Especially, it provides a perfect platform to explore the unique electronic properties in absolute two-dimension. Pristine graphene possesses zero band gap and weakens its competitiveness in the field of semiconductors. In order to induce a band gap and control its semiconducting properties, functionalization and doping are two of the most feasible methods. In the context of functionalization, large area monolayer graphene synthesized by chemical vapor deposition was subjected to controlled and sequential fluorination using radio frequency plasma while monitoring …
Race In Predominately White Schools : Implications For School Counselors., Katelyn Marie Gosnell Richey
Race In Predominately White Schools : Implications For School Counselors., Katelyn Marie Gosnell Richey
Electronic Theses and Dissertations
This study examined the phenomenon of white school counselors and the discussions about race that occur at predominately white schools. Research in the area of predominately white schools and discussions about race is severely lacking (Chandler, 2009; Chandler & McKnight, 2009). Additionally, many researchers and authors reported that conversations about race are either avoided or poorly managed in K-12 schools (Brown & Brown, 2010; Chandler & McKnight, 2009; Lintner, 2004; Burrell & Walsh, 2001; ; Loewen, 2007; Zimmerman, 2004). This points to an even greater importance on school counselors cultivating these conversations with the students at the schools in which …
Information Theoretic Thresholding Techniques Based On Particle Swarm Optimization., Surina Surina
Information Theoretic Thresholding Techniques Based On Particle Swarm Optimization., Surina Surina
Electronic Theses and Dissertations
In this dissertation, we discuss multi-level image thresholding techniques based on information theoretic entropies. In order to apply the correlation information of neighboring pixels of an image to obtain better segmentation results, we propose several multi-level thresholding models by using Gray-Level & Local-Average histogram (GLLA) and Gray-Level & Local-Variance histogram (GLLV). Firstly, a RGB color image thresholding model based on GLLA histogram and Tsallis-Havrda-Charv'at entropy is discussed. We validate the multi-level thresholding criterion function by using mathematical induction. For each component image, we assign the mean value from each thresholded class to obtain three segmented component images independently. Then we …
Understanding The Relationship Between Positive Affect And Cortisol In Lung Cancer Patients., Lauren Ann Zimmaro
Understanding The Relationship Between Positive Affect And Cortisol In Lung Cancer Patients., Lauren Ann Zimmaro
Electronic Theses and Dissertations
Positive psychobiological processes within lung cancer patients are drastically understudied. This dissertation explores the nature of positive affect (PA) and potential associations with diurnal cortisol among lung cancer patients, given the prognostic significance of diurnal cortisol rhythms. Theoretical underpinnings and current literature involving PA, cancer, and diurnal cortisol are first reviewed. An original integrated model of PA and cortisol among cancer patients is then presented, from which the proposed dissertation study and analyses are derived. Sixty-one non-small cell lung cancer patients provided self-report assessment of mood (PANAS PA and NA subscales, CES-D PA subscale), medical and demographic characteristics, and 10-day …
Coal Ash Exposure And Behavioral Impairments Among Children In Louisville, Kentucky., Chisom Nmesoma Odoh
Coal Ash Exposure And Behavioral Impairments Among Children In Louisville, Kentucky., Chisom Nmesoma Odoh
Electronic Theses and Dissertations
Introduction: Coal ash, generated from the combustion of coal is principally made up of fly ash, which consists of small particles and metals that can affect the development of children. Coal ash is predominately stored in landfills and surface impoundments, of which many are in proximity to residential areas. According to the Environmental Protection Agency, 25% of residents in proximity to electric power plants are children. Few studies have reported a positive association between coal ash and its by-products and neurobehavioral disorders. The purpose of this study was to explore the relationship between coal ash and its components and …
Generalized Spatiotemporal Modeling And Causal Inference For Assessing Treatment Effects For Multiple Groups For Ordinal Outcome., Soutik Ghosal
Generalized Spatiotemporal Modeling And Causal Inference For Assessing Treatment Effects For Multiple Groups For Ordinal Outcome., Soutik Ghosal
Electronic Theses and Dissertations
This dissertation consists of three projects and can be categorized in two broad research areas: generalized spatiotemporal modeling and causal inference based on observational data. In the first project, I introduce a Bayesian hierarchical mixed effect hurdle model with a nested random effect structure to model the count for primary care providers and understand their spatial and temporal variation. This study further enables us to identify the health professional shortage areas and the possible impacting factors. In the second project, I have unified popular parametric and nonparametric propensity score-based methods to assess the treatment effect of multiple groups for ordinal …
Canonical Nuclear Factor-Κb Signaling In Satellite Stem Cell Homeostasis And Function., Alex R. Straughn
Canonical Nuclear Factor-Κb Signaling In Satellite Stem Cell Homeostasis And Function., Alex R. Straughn
Electronic Theses and Dissertations
Satellite cells are adult stem cells that are required for the regeneration of skeletal muscle following injury. However, the signaling mechanisms that regulate satellite stem cell homeostasis and function in adult animals remain less understood. Nuclear factor-kappa B (NF-kB) is a major nuclear transcription factor that regulates the gene expression of a plethora of molecules involved in cellular proliferation, differentiation, survival, and the inflammatory immune response. NF-kB can be activated through a canonical or non-canonical pathway. However, the role of canonical NF-kB signaling in the regulation of satellite stem cell function during skeletal muscle regeneration has not been yet investigated …
High Dynamic Range Optical Devices And Applications., Elijah Robert Jensen
High Dynamic Range Optical Devices And Applications., Elijah Robert Jensen
Electronic Theses and Dissertations
Much of what we know about fundamental physical law and the universe derives from observations and measurements using optical methods. The passive use of the electromagnetic spectrum can be the best way of studying physical phenomenon in general with minimal disturbance of the system in the process. While for many applications ambient visible light is sufficient, light outside of the visible range may convey more information. The signals of interest are also often a small fraction of the background, and their changes occur on time scales so quickly that they are visually imperceptible. This thesis reports techniques and technologies developed …
Evaluation Of Drug-Loaded Gold Nanoparticle Cytotoxicity As A Function Of Tumor Tissue Heterogeneity., Hunter Allan Miller
Evaluation Of Drug-Loaded Gold Nanoparticle Cytotoxicity As A Function Of Tumor Tissue Heterogeneity., Hunter Allan Miller
Electronic Theses and Dissertations
The inherent heterogeneity of tumor tissue presents a major challenge to nanoparticle-medicated drug delivery. This heterogeneity spans from the molecular to the cellular (cell types) and to the tissue (vasculature, extra-cellular matrix) scales. Here we employ computational modeling to evaluate therapeutic response as a function of vascular-induced tumor tissue heterogeneity. Using data with three-layered gold nanoparticles loaded with cisplatin, nanotherapy is simulated with different levels of tissue heterogeneity, and the treatment response is measured in terms of tumor regression. The results show that tumor vascular density non-trivially influences the nanoparticle uptake and washout, and the associated tissue response. The drug …
The Role Of Hardiness In The Relation Between Perceived Daily Discrimination And Depressive Symptoms In Community College Students., Rosamond J. Smith
The Role Of Hardiness In The Relation Between Perceived Daily Discrimination And Depressive Symptoms In Community College Students., Rosamond J. Smith
Electronic Theses and Dissertations
In the current study, perceived daily discrimination (PDD) is conceptualized as a chronic stressor which repeatedly activates a stress response and results in depressive symptoms, per the theory of allostatic load. Psychological hardiness is explored as a potential moderator of the relation between PDD and depressive symptoms, because individuals who repeatedly demonstrate hardiness may be primed for making cognitive reappraisals of potential stressors and/or for mobilizing appropriate coping strategies, thus limiting the body’s repeated stress responses and subsequent depressive symptoms. This cross-sectional survey of a diverse sample of 305 community college students included measures of hardiness (Dispositional Resilience Scale, …
Solving School Bus Routing And Student Assignment Problems With Heuristic And Column Generation Approach., Di Zhang
Electronic Theses and Dissertations
In this dissertation, we solve a school bus routing problem of transporting students including special education (handicapped) students and assigning them in Oldham county education district. The main contribution of this research is that we consider special education students (Type-2) along with other students (Type-1) and design a comprehensive school bus schedule to transport both kinds of students at the same time. Also, a student assignment mathematical model is presented to optimize the number of bus stops in use as well as one important measure of service quality, the total student walking distance. Comparing to the classic clustering methods, heuristic …
Spam Elimination And Bias Correction : Ensuring Label Quality In Crowdsourced Tasks., Lingyu Lyu
Spam Elimination And Bias Correction : Ensuring Label Quality In Crowdsourced Tasks., Lingyu Lyu
Electronic Theses and Dissertations
Crowdsourcing is proposed as a powerful mechanism for accomplishing large scale tasks via anonymous workers online. It has been demonstrated as an effective and important approach for collecting labeled data in application domains which require human intelligence, such as image labeling, video annotation, natural language processing, etc. Despite the promises, one big challenge still exists in crowdsourcing systems: the difficulty of controlling the quality of crowds. The workers usually have diverse education levels, personal preferences, and motivations, leading to unknown work performance while completing a crowdsourced task. Among them, some are reliable, and some might provide noisy feedback. It is …
The Effects Of Monaural And Binaural Cues On Perceived Reverberation By Normal Hearing And Hearing-Impaired Listeners., Gregory Matthew Ellis
The Effects Of Monaural And Binaural Cues On Perceived Reverberation By Normal Hearing And Hearing-Impaired Listeners., Gregory Matthew Ellis
Electronic Theses and Dissertations
This dissertation is a quantitative and qualitative examination of how young normal hearing and young hearing-impaired listeners perceive reverberation. A primary complaint among hearing-impaired listeners is difficulty understanding speech in noisy or reverberant environments. This work was motivated by a desire to better understand reverberation perception and processing so that this knowledge might be used to improve outcomes for hearing-impaired listeners in these environments. This dissertation is written in six chapters. Chapter One is an introduction to the field and a review of the relevant literature. Chapter Two describes a motivating experiment from laboratory work completed before the dissertation. This …
Perinatal Nicotine With Or Without Early Life Influenza Infection Leads To Lung Dysfunction With Age., Ryan Carroll Mcallister
Perinatal Nicotine With Or Without Early Life Influenza Infection Leads To Lung Dysfunction With Age., Ryan Carroll Mcallister
Electronic Theses and Dissertations
Obstructive Airway Diseases (OADs) affect millions of people worldwide, and are characterized by chronic inflammation and tissue remodeling in the lung. It has been proposed that the development of OAD is greatly influenced (and perhaps pre-determined) by early life events, such as maternal smoking or a viral infection. However, direct evidence of this is limited and the mechanisms involved remain unclear. Our laboratory previously developed a murine model of perinatal nicotine exposure, and reported that nicotine leads to airway remodeling and decreased pulmonary function in the offspring. We discovered these effects were mediated through the α7 nicotinic acetylcholine receptor (nAChR). …