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Sustained Delivery Of Carbon Monoxide (Co) Via Organic Co Prodrugs: Pharmacokinetic Studies, Minjia Wang

Electronic Theses and Dissertations

Carbon monoxide (CO) is widely known as poisonous gas. Its role as a signaling molecule (gasotransmitter) with various therapeutic effects is less known. Recent years have seen a surge of interest in CO because of its demonstrated therapeutic effect in treating conditions such as inflammation, drug-induced toxicity, ischemia-reperfusion injury, and kidney injury, among others. In developing CO-based therapeutic agents, one key issue is the availability of pharmaceutically acceptable ways of delivering CO. During the past decade, there has been a large number of experiments in cell culture, animal models, and clinical trials using CO gas incubation/inhalation and heavy metal based …

Progress In Natural Product-Inspired Drug Discovery, Md Imdadul Huque Khan

Electronic Theses and Dissertations

Natural products and product-derivatized molecules are significant sources for drug discovery and development, and many have been discovered and developed to treat various diseases, including cancer, infectious diseases, neurological disorders, etc. This dissertation reports on the progress of our natural product-inspired research in the discovery of new compounds to treat cancer, infectious diseases, and neuroHIV.

We discovered many glutamine-based compounds and prodrugs that are effective in suppressing the growth of several breast cancer cell lines without introducing cytotoxicity in a non-cancerous cell line. Our lead compound has shown good exposure to the brain, and several compounds were also found to …

The Current State Of School Culture In Elementary Schools In Mississippi During The Covid-19 Pandemic, Rodney Harrison Hurt

Electronic Theses and Dissertations

In the Spring of 2020, the Covid-19 pandemic changed not only the way in which our daily lives were carried out, but it also drastically effected the way schools operated. Many if not all school districts in the state of Mississippi began operating in some type of remote fashion during the spring of 2020. Some school districts switched to an online format while others operated using a hybrid model which may have included work packets being completed at home or a combination of the two. The type of model by which each school operated often depended on the resources available …

Cosmology Of Wanderers, Hussain Ahmed

Electronic Theses and Dissertations

On the 14th of April 2014, a group of insurgents that the world later know to be Boko Haram, kidnapped 276 mostly female students in Chibok, Borno State, Nigeria. The disaster led to the death of thousands of military personnel and vigilante group members, mostly young men. Since that night, millions of people have been displaced. This thesis focused on inter and intra African migrations that result in the aftermath of the abduction.

A History Of Freed Slaves' Homes In Northern Nigeria, 1900-1926, Ajibola A. Abdulrahman

Electronic Theses and Dissertations

This dissertation is about the children rescued from slave traders by the British colonial government in Northern Nigeria in the early twentieth century. The children were first settled in state-owned Freed Slaves Homes located at Zungeru and Borno provinces in 1904. After the state-owned Homes were abolished in 1909, they were moved to the privately-owned Lucy Memorial Freed Slaves’ Home. The study focuses on the experiences of these liberated children within the premises of the Freed Slaves' Homes and in settings outside of these institutions in Northern Nigeria. Drawing on previously unused archival materials obtained from various parts of the …

Formulation Development Of Famotidine Floating Tablets Using Hot-Melt Extrusion Coupled With 3d Printing Technique., Esraa Al Shawakri

Electronic Theses and Dissertations

The main goal of this study is to develop a floating tablet of famotidine using hot melt extrusion coupled (HME) with Fused deposition modeling FDM 3D printing technology. Seventeen different formulations were prepared to obtain printable HME filaments. Hydroxypropyl cellulose (HPL-LF), hydroxypropyl cellulose (HPLC-EF), Hydroxypropyl Methylcellulose (HPMC-E5), and Ethyl Cellulose (EC) were used as polymeric carriers with 10% (w/w) famotidine. Polyethylene Glycol 1500 (PEG-1500) was used as a plasticizer. The resulting physical mixtures were then extruded using an 11 mm twin-screw co-rotating extruder (Thermo Fisher Scientific, Waltham, MA, USA). The HME filaments were then printed using an FDM-3D printer (Prusa …

The Truth Value Of Sentences With Legal Empty Terms., Jose Cubillo

Electronic Theses and Dissertations

There is an ongoing debate in philosophy about whether simple sentences containing fictional names are sometimes true, always false, or neither true nor false. Ordinarily, a simple sentence containing names is true if and only if the things designated by those names are the way they are ascribed as being, and false otherwise. For example, the sentence “Faulkner lived in Mississippi” is true because the person designated by ‘Faulkner’ lived in Mississippi whereas the sentence “Faulkner lived in Costa Rica” is false because that person did not reside there. However, this analysis clearly does not work for sentences such as …

The Relationship Between Ethnicity, Immigrant Generation, & Delinquency: Examining Youth In Child Protective Services., Erin Leigh Geist

Electronic Theses and Dissertations

Although minority youth are overrepresented in the makeup of the welfare and juvenile justice system, there is a lack of research that examines dually-involved youth. In recent years, there has been an escalation in the number of Hispanic youth that have become involved in the child welfare system, including youth that identify as Hispanic immigrants. This study uses nationally representative data of children receiving welfare services to examine the relationship between ethnicity, immigrant generation, and delinquency. The results of binomial regression models illustrated that there was no effect of Hispanic ethnicity or immigrant generation on delinquency. However, the analysis provided …

The Perception And Strategies Of Speech-Language Pathologists In Rapport Building With People With Aphasia Via Tele-Practice: Qualitative And Quantitative Mixed Design, Emily Hershberger

Electronic Theses and Dissertations

Introduction: Tele-practice has become an important service delivery method, especially since the Covid-19 pandemic. A majority of research investigated effectiveness in therapeutic outcomes among children and adolescents, while tele-practice studies among people with aphasia were relatively limited. Rapport building may present more challenges in tele-practice compared to in-person services, yet no study compared it across the two therapy delivery approaches among people with aphasia.

Method: This current study conducted interviews regarding how rapport building is affected in tele-practice from speech-language pathologists (SLPs) who have experienced both in-person and tele-practice among people with aphasia. Nine SLPs were interviewed about their perceptions …

Foolish Games: Stories, Victoria Jayne Hulbert

Electronic Theses and Dissertations

A collection of original short stories.

"The Wild Asleep": A Cultural And Environmental History Of Ramps, Catherine Jessee

Electronic Theses and Dissertations

Ramps, wild onions, or allium tricoccum are a variety of spring ephemeral, or a flowering plant that emerges for a brief period every spring. In working through stereotypical ideas about Appalachian regional identity, I interpret the environmental history of this plant. Incorporating memory, oral histories, and folklore, this thesis complicates wider conceptions of home, community, and boundary. Tapping into an archive of ramps knowledge as it is created, I ask, what can the future of ramps tell us about place, space, and belonging?

The Resilience Of Black Love, Janeth Jackson

Electronic Theses and Dissertations

For countless years, a network of laws, codes, systemic structures, and malicious forces have been established to eradicate Black love. Despite such evils, African Americans have been steadfast in their love for one another. In the American South, the evidence of that steadfastness is the strongest. States like Mississippi, Georgia, and Louisiana all had racist systems such as slavery, Jim Crow, Black Codes, and lynching that African Americans faced daily. And within each structure, there were methods employed to separate Black couples. Some historical texts have examined the plight of African American couples’ fight against such systems. However, few studies …

No Person Is An Island: A Multi-Level Analysis Of The Relationship Between Self-Determination Theory And Well-Being, Lauren Nichole Jordan

Electronic Theses and Dissertations

Individuals frequently work collaboratively with others in school, workplaces, and in their daily lives. As such, the group literature has focused on several concerns that individuals have in groups such as making choices with others, feeling competent, and getting along with others. One such theory that addresses these concerns at the individual level is self-determination theory, or the idea that people must be satisfied in their needs for autonomy, competence, and relatedness to experience growth and well-being. The purpose of this project was to determine whether self-determination theory replicates in groups and whether individuals’ perceptions that their groups are autonomous, …

Assessing The Effectiveness And Utility Of A Mindfulness-Based Ecological Momentary Intervention In College Students, Jeffrey Pavlacic

Electronic Theses and Dissertations

Mental health problems are common and increasing in college students. Despite the high prevalence rates of mental health problems in college students, a small percentage of students seek treatment. Low treatment seeking is associated with different factors, such as stigma, financial barriers, and emotion dysregulation. Identifying and delivering evidence-based treatments is critical to curtailing mental health problems and promoting psychological well-being in this population. One intervention that offers significant promise is Ecological Momentary Intervention (EMI), which incorporates technology to administer interventions. EMIs are widely applied for heterogeneous psychological problems and effective through different modalities. Mindfulness-based interventions (MBIs) ameliorate psychological distress …

Diversity And Inclusion In Science Teaching Learning (Distl): Focusing On The Perspectives Of Undergraduate Students And Graduate Teaching Assistants In The Chemistry Classroom, Albert Aidoo

Electronic Theses and Dissertations

Students in Science, Technology, Engineering and Mathematics (STEM) come with a wide range of experiences and educational backgrounds. There is high attrition rate and low academic achievement among students in STEM areas, specifically in college chemistry courses that are prerequisites for many STEM majors. Hence it is important to look at diversity and inclusion specifically in first- and second-year college chemistry courses to address the challenge of student attrition in STEM. Diversity can be understood as the differences each student brings along the dimensions of prior knowledge, skills, race, ethnicity, sexual orientation, gender, socio-economic status, age, ability, religious or political …

Genome-Wide Identification Of Wrky Transcription Factor Encoding Genes In Amborella Trichopoda Baill. (Amborellaceae), Bijaya Pradhan

Electronic Theses and Dissertations

WRKY transcription factors (TFs) are DNA-binding proteins, which play important roles in managing plant stresses and regulating growth and development processes. The WRKY TF family has expanded significantly through genome/gene duplications in the plant evolutionary process. Although the WRKY TFs have been identified in hundreds of plant species, they are yet to be identified in Amborella trichopoda, a species that represents the most basal group of Angiosperms. The main objectives of this study were to conduct genome-wide identification of the WRKY gene family in A. trichopoda and to assess their homologs in Angiosperms. In this study, we identified …

Effects Of Conservation Management Practices On Soil Health And Crop Yields In Eastern South Dakota, Alex Mclain

Electronic Theses and Dissertations

Conservation management practice adoption on agricultural land has increased in recent years due to increasing public and private investment. The anticipated impact of increasing conservation management practice adoption are reduced greenhouse gas emissions and improved soil, water, and air quality. Understanding how these conservation management practices affect agricultural producers economically is vital to properly incentivize these practices. The existing literature on how conservation management practices affect soil health and crop yields is mixed and generally has been conducted on experimental research stations. These studies may not fully account for the on-farm effects of conservation management practices. The objectives of this …

Trace Mineral Source And Inclusion Level On Wean-To-Finish Pig Production, Marissa Larosae

Electronic Theses and Dissertations

Trace mineral requirements to optimize production for swine are not well defined, leading to excess trace mineral supplementation in swine diets and ultimately to excess trace minerals excreted in swine manure. Potential strategies to reduce the waste of excess trace minerals in diets include utilizing organic sources with higher bioavailability or reducing the overall trace mineral supplementation in the diet. Two studies were conducted in an effort to determine if utilizing organic trace minerals or reducing trace mineral inclusion into diets has an impact on overall performance measurements for nursery and grow-finish pigs, respectively. The first experiment utilized 1,144 weaned …

Totally Multicolored Rado Numbers For The Equation X_1 + X_2 + X_3 + ... + X_(M−1) = X_M, Skylar Halverson

Electronic Theses and Dissertations

A set is called Totally Multicolored (TMC) if no elements in the set are colored the same. For all natural numbers t, m, let R(t, m) be the least natural number n such that for every t-coloring of the set {1, 2, 3, ..., R(t, m)} there exist a solution set {x_1, x_2, . . ., x_m} to L(m), x_1 + x_2 + x_3 + ... + x_(m−1) = x_m such that x_i does not equal x_j for all i that does not equal j, that avoids being Totally Multicolored. This paper shows a function to find R(t,m) for any …

Disclosing For Closure: Negotiating Boundaries For Self-Expansion After Violence, Jadah M. Morrison

Electronic Theses and Dissertations

The #MeToo movement has brought the narratives of survivors of sexual assault center stage. As we begin to understand the intricacies of these narratives, we must remember them in their first iteration, their initial disclosure. This study aims to understand the motivations behind the first disclosure of sexual violence. Through looking at these motivations through the lens of self-expansion theory, we can better support survivors of sexual violence in this initial process. Self-discrepancy theory was also used to understand survivors’ sense of self, and the motivations of how survivors seek refuge in their receiver. Thus, privacy management lends itself to …

Using Long Short-Term Memory Networks To Make And Train Neural Network Based Pseudo Random Number Generator, Aditya Harshvardhan

Electronic Theses and Dissertations

Neural Networks have been used in many decision-making models and been employed in computer vision, and natural language processing. Several works have also used Neural Networks for developing Pseudo-Random Number Generators [2, 4, 5, 7, 8]. However, despite great performance in the National Institute of Standards and Technology (NIST) statistical test suite for randomness, they fail to discuss how the complexity of a neural network affects such statistical results. This work introduces: 1) a series of new Long Short- Term Memory Network (LSTM) based and Fully Connected Neural Network (FCNN – baseline [2] + variations) Pseudo Random Number Generators (PRNG) …

E. Coli Persister Cell Survival And Rhizobia Attachment To Soybean Roots, Tanim Islam

Electronic Theses and Dissertations

The theme of this thesis revolves around how bacteria respond and thrive during stress. Chapters 1-3 are about how bacteria deal with life-threatening antibiotics. Chapter 4 covers new research on how bacteria can move from a stressful individual lifestyle (free-living bacteria) to initiating a symbiotic relationship with a plant (a less stressful lifestyle). In Chapter 1, I briefly summarize the current state of knowledge in the field of antibiotic resistance and persistence. In Chapter 2, I add to this knowledge by providing new insights into several antibiotics' potency and exploring the antibiotic Eagle effect. In Chapter 3, I use pyruvate …

Identifying Adp-Ribosylation As The Biochemical Signal That Marks Dna-Protein Crosslinks For Sprtn-Dependent Proteolysis, Katelyn Hurley

Electronic Theses and Dissertations

DNA-protein crosslinks (DPCs) form when proteins covalently attach to DNA. It is estimated that hundreds of DPCs form in our cells each day. Because these lesions are cytotoxic, mammalian cells have evolved multiple intricate repair systems to remove DPCs and restore genome integrity. One mechanism mammalian cells rely on for DPC repair is direct proteolysis by the metalloprotease, SPRTN. While it is known that SPRTN degrades a heterogenous array of DPCs, including both naturally occurring and chemically induced, how SPRTN selects DPCs amongst chromatin-associated proteins remains unknown. Our main objective is to determine how DPC repair is regulated. In Chapter …

Assessment Of Aged Woodchip Bioreactor Physical And Hydraulic Properties, Shelby Duncan

Electronic Theses and Dissertations

Denitrifying woodchip bioreactors are a critical tool for mitigating nitrate loading to downstream water bodies. The properties of the woodchip are a key factor in the design of the bioreactor which are usually designed to optimize that retention time of the water being treated. Retention time is affected by active flow volume, porosity, and flow rate. As a bioreactor ages, the carbon material will break down and, in some cases, sedimentation will occur within the bioreactor. Both processes will affect the porosity and hydraulic performance of the bioreactor. When flow through the bioreactor is significantly different than the original design, …

A Novel Crispr/Cas Gene Editing System For Plants Which Bypasses Genetic Transformation And Tissue Culture, Aastha Acharya

Electronic Theses and Dissertations

CRISPR/Cas system is a powerful gene-editing tool that has revolutionized gene editing in many ways. However, the current delivery methods for using CRISPR/Cas system inn plants have some drawbacks that have greatly limited their routine application in plant research and improvement. Specifically,, the methods heavily rely on either genetic transformation for delivering Cas and/or its gRNA coding sequences into the targeted cells or tissue culture, or both for recovering the whole edited plants. To overcome these drawbacks, we have developed a simple, easy to use yet effective system for CRISPR/Cas gene editing in plants that can bypass genetic transformation and …

The Efficacy Of The South Dakota State University Summer Jacks Leap Program, Tessa M. Sundermann

Electronic Theses and Dissertations

Today, several studies detail the continuing struggle many students have with college mathematics courses at universities across the United States. The South Dakota State University Summer Jacks LeaP program is a summer bridge mathematics program aimed at improving incoming students’ mathematics success. This analysis used a mixed methods research design to examine the efficacy of the Summer Jacks LeaP program. First, we analyzed the LeaP students’ homework averages, exam 1 scores, final exam scores, and overall grade scores to determine if they were finding success in their fall semester mathematics courses. We also used hypothesis testing to compare LeaP participants …

Electron Spin Relaxation Of Nitroxide Spin Labels And Relaxation Processes, Thacien Ngendahimana

Electronic Theses and Dissertations

MTSL is the nitroxide spin label that is most commonly used in site-directed spin labeling. However, due to rotation of its gem-dimethyl groups that average anisotropic interactions, T_m becomes short above about 70 K and this makes DEER experiments difficult at these temperatures. Strategies for decreasing spin echo dephasing and electron spin lattice relaxation rates are important for design of nitroxide spin labels and molecular qubits.

In searching for labels with longer T_m, new nitroxide spin labels devoid of gemdimethyl groups or with more rigid structures were synthesized at the University of Nebraska and pulsed EPR measurements …

On Ramsey And Gallai-Ramsey Numbers Of Some Classes Of Graphs, Qinghong Zhao

Electronic Theses and Dissertations

In 1930, Frank Ramsey showed that one will find a monochromatic clique of a specified size in any edge coloring of a sufficiently large complete graph. This result is commonly known as Ramsey's theorem. The role of Ramsey number is to quantify some specific problems related to Ramsey's theorem. Given a graph H, the Ramsey number R_2(H) is the minimum integer p such that every 2-edge-coloring of the complete graph K_p contains a monochromatic copy of H. Ramsey numbers have been a hot topic in graph theory for decades due to their intrinsic beauty, wide applicability and overwhelming difficulty. Let …

Beneficial Plant-Microbe Interactions To Improve Nutrient Uptake And Biotic Stress Response In Crops, Jaya Krishna Yakha

Electronic Theses and Dissertations

Mutualism is a very common phenomenon among living organisms on earth. Legumes because of their high protein content, serve as a great nutrient resource for animals. This group of plants can form a mutualistic symbiosis with beneficial microbes. For example, Alfalfa (Medicago) and soybean (Glycine max) can get colonized with arbuscular mycorrhizal fungi (AMF) and rhizobia bacteria simultaneously forming a complex tripartite interaction for nutrient benefits. Most of the previous research evaluated individual symbionts, either rhizobia bacteria or AMF, but not both. There are only a few reports which discuss the nutrient exchange mechanisms in a tripartite interaction. Thus, there …

Heuristic Algorithms For Transmission Switching To Reduce Load Shedding, Tanveer Hussain

Electronic Theses and Dissertations

No abstract provided.