Digital Commons Network^™

Cellular Mechanisms Of Igf-1 Neuroprotection After Ischemic Stroke, Cellas A. Hayes

Electronic Theses and Dissertations

Strokes are a leading cause of mortality and disability worldwide; thus, there is a dire need for new, effective pharmacotherapeutics that can be administered to reduce the burden of disease post-insult. Clinical findings have shown that insulin-like growth factor-1 (IGF-1) levels and post-stroke functional outcomes exhibit a positive relationship. Importantly, the administration of exogenous IGF-1 in rodent models of ischemic stroke attenuates neurological damage and functional deficits following stroke. Ongoing stroke damage after the initial insult is primarily induced by increased extracellular glutamate causing substantial neuronal death, increased neuro-inflammation, and leading to greater tissue loss. Evidence from our laboratory has …

Physiological Corticosterone Attenautes Gp120-Mediated Microglial Activation And Is Associated With Reduced Anxiety-Like Behavior In Gp120-Expressing Mice, Emaya Marie Moss

Electronic Theses and Dissertations

Human immunodeficiency virus (HIV) persists as a global pandemic. Despite the benefits of combinatorial antiretroviral therapies (cART), virotoxic HIV proteins are still detectable within the central nervous system and approximately half of all cART-treated patients contend with neurological impairments. The mechanisms underlying these effects are not known, but likely involve actions of virotoxic HIV proteins including glycoprotein 120 (gp120). Glycoprotein 120 is neurotoxic, in part due to its capacity to activate microglia. Corticosterone, an endogenous anti-inflammatory, has been found to attenuate neuronal death caused by gp120-induced microglial cytokine production in vitro. But, the concentration-dependent effects of corticosterone to influence microglial …

Effects Of Tonic Drone And Singing On The Pitch Accuracy Of Middle And High School String Players, Starkey Allen Morgan

Electronic Theses and Dissertations

The purpose of this study is to determine the effects of tonic drone, and tonic drone and singing on the intonation accuracy of middle school and high school string students in a classroom setting. Participants (N=58) in the study included middle and high school string players from two school districts in northern Mississippi. Tonic drone (n=22) and tonic drone and singing (n=36) groups were comprised of one middle school and one high school class each. One group performed pitch–matching exercises that include a tonic drone while the second group performed pitch-matching exercises that included the tonic drone and singing. A …

Controlling Rate Of Interfacial Electron Transfers Via Synthetic Modulation Of Organic Chromophores, Christine Curiac

Electronic Theses and Dissertations

Solar energy technologies, such as dye-sensitized solar cells (DSCs) and photoelectrochemical cells (PECs), rely on electron transfer reactions to convert light waves from the Sun to usable electrical energy. These electron transfers are vital to the performance of solar energy technologies. However, two main unproductive electron transfers (recombination and back electron transfer) are possible in these systems, making it vital to study and increase the efficiency of the beneficial electron transfers while hindering the possibility of unproductive pathways from occurring. Through modulation of the organic chromophore/dye used in DSCs, lower recombination rates, and back electron transfer rates are afforded. Three …

Biopolymer Unfolding As A Process Of Biased Activated Barrier Crossing, Sudeep Adhikari

Electronic Theses and Dissertations

The biopolymer unfolding process can be conceptualized as the thermally activated crossing of a barrier in some energy landscape; the real-world unfolding dynamics are in correspondence with the rate of transit over the barrier. In this dissertation, we report on four projects that exploit this analogy to advance our understanding of so-called pulling experiments, in which a biopolymer chain is encouraged to unfold by direct application of forces to its two ends. Regardless of the specific experimental realization, standard pulling techniques give rise to a biased barrier crossing problem. The applied force has the effect of tilting the energy landscape. …

Visitation, Ellie Black

Electronic Theses and Dissertations

A collection of poems.

Linguistic Expressions Of Pidgin In Nigerian Stand-Up Comedy, Jimoh Junior Braimoh

Electronic Theses and Dissertations

This dissertation is a study of the comics’ lexical choices and how they achieve their goals with words. The comics’ choice of words is far from being incidental, superficial, or supplementary. Performers’ choices of words show how their ideas are embodied in language. That is to say, the effect of how a comedian uses words and humor strategies is vital for understanding the contextual meaning of jokes and how they appeal to logic and reason. The objectives are to identify and categorize lexical choices and interpret their denotative, connotative, and affective meanings. Based on the Incongruity Theory (Attardo, 1994) Data …

Student Success: Do First-Time, Full Time (Ftft) Students At The University Of Mississippi Enrolled In Intermediate Math (Ds 099) Earn Higher Grades In College Algebra (Math 121) Than Those Students Who Enrolled Directly In College Algebra?, Martina Brewer-Mister

Electronic Theses and Dissertations

Critics of developmental studies suggest that remedial courses may negatively influence a student’s program selection, persistence, and completion because remedial classes do not count toward graduation requirements (Long & Boatman, 2013). They have also found that over half of the students referred to remediation do not complete the courses (Clayton, Crosta, & Belfield, 2014; Bailey, Jeong, & Cho, 2010). The number is even lower for minority students (Bailey, 2010).

Using pre-existing data collected from the Office of Institutional Research, Effectiveness, and Planning at the University of Mississippi, an independent sample t-test and correlation analysis were conducted to examine the outcomes …

Extra-Legal Factors In Juvenile Court Outcomes: What Is The Role Of Youth’S Race/Ethnicity And Family Structure In Disposition Decisions?, Vitoria De Francisco Lopes

Electronic Theses and Dissertations

Due to the unique nature of the juvenile justice system, its focus on rehabilitation and the population it serves, juvenile court judges serve as the sole decision maker and are given substantial power of discretion. Prior literature has indicated extra-legal factors to influence court outcomes, and scholars have argued that the use of discretion has led to a significant variability in the way youth are treated by juvenile court officials and may contribute to the issue of minority overrepresentation in the juvenile justice system. Yet, family structure has not been examined in depth, especially as it relates to race/ethnicity. The …

On The Distribution Of The Number Of Prime Factors Of An Integer, Jacob Mitchell Derrick

Electronic Theses and Dissertations

The distribution of the prime numbers has intrigued number theorists for centuries. As our understanding of this distribution has evolved, so too have our methods of analyzing the related arithmetic functions. If we let ω(n) denote the number of distinct prime divisors of a natural number n, then the celebrated Erdős –Kac Theorem states that the values of ω(n) are normally distributed (satisfying a central limit theorem as n varies). This result is considered the beginning of Probabilistic Number Theory. We present a modern proof of the Erdős–Kac Theorem using a moment based argument due to Granville and Soundararajan, which …

Spectroscopic Investigations Of Newly Developed Materials For Light Harvesting, Energy Conversion, And Bioimaging, Austin L. Dorris

Electronic Theses and Dissertations

A multitude of spectroscopic techniques were employed in the making of this dissertation to investigate materials with environmental, commercial, optoelectronic, bioimaging, and solar energy conversion applications. Graphene-like materials like biochar represent a field of study in which bioavailable materials are deployed for CO2 and heavy-metal adsorption to combat the detrimental effects of industry on the environment. Vibrational characterization of these materials via Raman spectroscopy is integral in elucidating the structure-function relationship and determining the best approach for material preparation and functionalization. Carbonaceous systems such as cellulose are also studied via Raman spectroscopy to interrogate the viability of cellulose nanocrystals as …

Applications Of Correlated Gaussian Functions To Few-Body Ions, William Earwood

Electronic Theses and Dissertations

For few-body systems, the Schrödinger equation can be solved using the linear variational method, where the wavefunction is expanded in a set of parameterized, all-particle functions. However, it remains a challenging task to determine a quality set of nonlinear parameters that result in accurate wavefunctions when the Schrödinger equation is solved from the solution to an eigenvalue problem. In this work, a stochastic optimization algorithm has been implemented to drive the optimization of wavefunctions and first-order perturbed functions. For Z ≤ 10 lithiumlike ions, variational wavefunctions are determined for the 22S, 22P, 32P, 42P, and 52P states. For the Z …

Core Size Conversion And Ligand Effects On Gold Nanomolecules Structure And Properties., Senthilkumar Eswaramoorthy

Electronic Theses and Dissertations

The size, shape and structure of the materials determines its properties in any scale. When the size of the material reaches nanometer scale, it shows a strikingly different property from the bulk. Monodisperse metal nanoparticles are highly desired due to its unique properties which can be explored for targeted applications. The nanoparticles with size less than 3 nm, atomically precise metal nanoparticles can be achieved, whereas nanoparticles in 3-100 nm range are monodisperse in size but not atomically monodisperse. Thiolate protected gold nanoparticles size less than 3 nm forms highly stable atomically precise compounds with distinct number of gold atoms …

Socialization To Research And Sponsored Programs Administration Through Transformative Learning: A Qualitative Exploration Of Faculty Perceptions At The University Of Mississippi, Melissa Hodge-Penn

Electronic Theses and Dissertations

This study examined faculty socialization at the University of Mississippi regarding research and sponsored program administration through the lens of transformative learning. Participants were 10 tenure track faculty who had been employed at the University of Mississippi no less than one year, no more than seven years, and who had submitted a proposal to or been awarded by an external sponsor to support their research. This study uses a phenomenological design of inquiry where the researcher describes the lived experiences of individuals regarding a phenomenon as defined by the participants through semi-structured interviews. Findings suggested that sponsored research faculty perceived …

Fugitivity, Confinement, And The Afterlife Of Slavery In Contemporary African American Migration Narratives, Juyoun Jang

Electronic Theses and Dissertations

This dissertation investigates a post-Civil Rights-era literary history of fugitive slave figures and their fugitive acts amid temporal and spatial confinement as constituting a tradition of contemporary African American migration narratives. The point of departure for this project is the Prologue of Ralph Ellison’s novel, Invisible Man, where the unnamed Black narrator endures a forced migration to New York, but also invites readers to witness his performance of hibernation in an underground space in a building reserved for white tenants. On the one hand, the low, claustrophobic, and dark space of the narrator’s basement signifies Black migrants’ historical subjection to …

Motivation Of Individual Directors: A Consolidated Perspective, Yankun Jia

Electronic Theses and Dissertations

This dissertation studies the motivation of individual directors on the corporate board and the impact of the motivation of individual directors. Building on previous work, I synthesize self-determination theory, identity theory, and social identity theory to build a comprehensive framework to understand the motivation of individual directors. By analyzing the satisfaction or frustration of basic psychological needs, the engagement of social roles, and the self-categorization and social identification process, this dissertation delivers a preliminary probe into the micro-foundations of the motivation of individual directors in the corporate governance literature.

Kierkegaard's Self As Synthetic Tension, James Edward Johnson

Electronic Theses and Dissertations

Soren Kierkegaard was a nineteenth Danish thinker working within the Christian tradition. While he did not think of himself as a philosopher, much of his work as a writer in philosophical in nature and is important to the inquiry on the philosophy of the mind. Particularly within his work, The Sickness Unto Death, Kierkegaard presents an idea of the human self as a dialectic, understood to be a tension that must be maintained in the synthesis. This idea of the self a synthetic tension can be seen in Kierkegaard’s larger body of work, particularly within the programmatic scheme of the …

Guests Attitude And Purchase Intention Towards Hotel Vacation Rentals, Daegeun Kim

Electronic Theses and Dissertations

This study investigated hotel guests’ attitude towards hotel vacation rentals and their purchase intention by applying consumption value theory (CVT) and in the perspective of brand extension. More specifically, this study was divided in to 2 parts in which the first study attempted to investigate how potential hotel vacation rentals guests’ consumption values would affect their purchase intention (PUR) and whether brand loyalty plays a moderating role between the relationships. The second study examined the role of consumer brand identity (CBI) as a success factor of brand extension and which factors have an influence on potential hotel rental guests’ attitude …

Blood Tide: A Novel, Teagan Kessler

Electronic Theses and Dissertations

This is a work of fiction about a detective who moves to Louisiana to outrun a tragic incident in his past. In Louisiana, he catches a case involving the sheriff’s daughter, who has gone missing. Later found dead, the woman’s life comes to light through the detective’s investigation, all while he battles his PTSD.

First-Year Students' Perceptions Of Innate Intelligence, Ability, And Interest Across Four Stem Domains: A Comparative Structural Equation Model, Savannah Lea Kelly

Electronic Theses and Dissertations

Higher education institutions play a pivotal role in preparing students to acquire the skills necessary to enter the STEM workforce and serve as critical partners in the STEM educational-occupational pipeline. It is imperative that postsecondary institutions encourage equal opportunities for admittance into STEM domains. However, research has consistently demonstrated that gender and racial disparities continue to exist in STEM fields at the postsecondary level, particularly when viewed through the lens of disaggregated disciplinary data. One way to address inequitable attainment across STEM is to evaluate whether students prematurely preclude themselves from STEM participation due to a misalignment between students’ self-perceptions …

Faculty Perceptions Of Open And Affordable Education Resources, Megan Lowe

Electronic Theses and Dissertations

A now-common question regarding whether or not individuals should pursue college degrees is whether college is worth the cost. One of the ways that institutions of higher learning may help students reduce cost of attending college, thereby reducing the financial stresses, is to reduce expenses where possible. One place where institutions of higher learning can reduce expenses for students is course texts and materials. This reduction can be accomplished in several ways, but one way that has gained visibility is the use of open educational resources (OER) and affordable education resources (AER), also known as AOER. This qualitative research study …

Α-Tocopherol Succinate Nano Structured Lipid Carriers For The Ocular Delivery Of The Anticancer Agents And Statistical Modeling Of Release Study Profiles By Linear Mixed Models, Sushrut Marathe

Electronic Theses and Dissertations

Retinoblastoma (RB) is a rare type of cancer that develops quickly from immature retinal cells. Enucleation, external beam radiotherapy, episcleral plaque radiotherapy, and cryotherapy have been the treatment options for the RB.

Paclitaxel (PTX) is an effective antineoplastic medication with a wide range of applications in the treatment of malignant tumors., systemic toxicity, quick elimination, and resistance limit its clinical use. Due to its limited solubility, PTX formulations have proven difficult to develop, necessitating the use of Cremophor® EL and organic solvents. Furthermore, the blood-retinal barrier prevents PTX from penetrating into the ocular tissues. The goal of this work was …

Meaning In Life And Psychological Distress: Examining Veterans And Psychological Adaptation To Civilian Life, Victoria Mccutcheon

Electronic Theses and Dissertations

Veterans’ transition from the military to civilian life can be conceptualized as a cultural transition (i.e., acculturation). This transition means leaving the familiarity and consistency of military life and attempting to integrate one’s values, skills, expectations, and identity as a service member into the dominant civilian culture. The present study seeks to examine the psychological adaptation component of acculturation (i.e., the individual’s feelings and perceptions of being in the new culture) in a veteran sample, as it relates to meaning in life. The existing body of veteran literature has demonstrated that meaning and purpose (a distinct component of meaning) are …

Inevitable Mortality And The Incessant Momentum Of Medicalized Death, Clifford Mckay

Electronic Theses and Dissertations

Atul Gawande, MD, affirms the inevitability of human mortality and the end of life in natural death. He decries current medical delivery’s incessant momentum toward medicalized death and recommends a meaningful conversation between doctor and patient to chart a course of care that supports what is important to the patient. But the tradition of a doctor’s dominance and a patient’s submissiveness disrupts the conversation. New definitions of both doctor and patient, and the intent to respect a patient’s autonomy, will facilitate decision-making and support patients’ values at the end of life, diminishing the momentum of medicalized death.

The Effects Of Advocate Disclosure On Perceptions Of A Female Child Who Stutters, Peyton Mcknight

Electronic Theses and Dissertations

Research indicates that people who stutter are frequently attributed with negative stereotypes by listeners as a result of their speech. Previous research has examined the use of self-disclosure in offering the stuttering community a means of acknowledging and sharing the presence of their stuttering with a conversation partner. Subsequently, stuttering self-disclosure has been shown to reduce negative listener perceptions. Select advocate disclosures have also been found to yield beneficial results for a male child who stutters, but the effects of advocate disclosure on perceptions of a female who stutters has remained unexplored. This study expands upon previous research and examines …

Culturally Responsive Pedagogy: A Model To Level The Playing Field For Black Students In A High Poverty Middle School, Shanika Mckinney

Electronic Theses and Dissertations

Academic failure and achievement gaps plague high-poverty school districts with majority-minority student populations. Culturally responsive pedagogy provides an opportunity for educators to bridge the gap caused by poverty and educational disparities. This applied research aimed to create a culture of teaching and learning that impacted student behavior and growth and proficiency in English Language Arts and math at a high poverty middle school. The eighth-grade teachers and students were exposed to this pilot program to increase teacher capacity in cultural responsiveness and increase student achievement. This applied research study utilized two action plan elements, which included professional development and implementation …

Flow Separation In Rotating Channels, Devika Vipul Patel

Electronic Theses and Dissertations

Direct numerical simulations are carried out to study the flow separation in a channel flow rotating about the spanwise axis. A bump is introduced on one side of the channel by an immersed boundary method. The numerical schemes are studied, the solver is validated, and the computational domain and grid resolution requirements are determined. The characteristics of the separating flow behind the bump are described by comparing the flow at rotation numbers Ro = 0, 0.42, and 1.0. The bulk Reynolds number of the channel is 2,500. Both clockwise and counterclockwise rotations at these two rates are examined. The bump …

Using Ab Initio Quantum Mechanical Methods For The Characterization And Isomerization Of Novel Compounds, Kimberley N. Poland

Electronic Theses and Dissertations

Computational quantum chemistry is the branch of chemistry derived from quantum mechanics to calculate structures and properties of molecules utilizing rigorous mathematical equations and approximations. This work focuses on utilizing wavefunction based methods to compute molecular properties such as optimized geometries, harmonic and anharmonic vibrational frequencies, dipole moments, strain energy, and isomerization channels with high degrees of accuracy, allowing for a direct comparison with previous work and experiment. Electronic structure modeling using various \textit{ab intio} methods can provide insight into the characterization and behavior of molecules otherwise unobserved, including, but not limited to, detection in the interestellar medium.

Investigating The Effects Of Absurd Humor And Mortality Salience On Moral Identity, Belongingness, Belief In A Just World, And Meaning In Life, Joshua Semko

Electronic Theses and Dissertations

Background: Humans have a sense of meaning, and people actively create and maintain meaning in their lives. One way humans make meaning is through fluid compensation, which is the automatic process of compensating for a threat to one’s global meaning system by temporarily strengthening other, non-related beliefs. This phenomenon has been thoroughly investigated in response to mortality salience (i.e., reminders of one’s death), but not absurd humor. This is important because little is known about the role of humor in meaning making. More research is needed to determine whether humor is a unique meaning-making process. Further, no studies have investigated …

The Effect Of Pitch Height On Instrument Gender Ratings, Raven Gordon Thompson

Electronic Theses and Dissertations

The purpose of this study was to examine the effect of pitch height on instrument gender ratings. This study’s participants (N=64) consisted of music major (n=32) and non-music major (n=32) students who are enrolled at the University of Mississippi. Using a 5-point semantic rating scale, participants rated the perceived masculinity and femininity of six musical instruments (flute, clarinet, saxophone, trumpet, trombone, tuba) as they are played at the approximate midpoint of their ranges and as they played in ranges that countered their established instrument-sex-stereotype. Specifically, female instruments (flute, clarinet) played in their low ranges while male instruments (trombone, tuba) played …