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International Doctoral Student Experiences In Educational Administration Programs In The United States: A Phenomenological Study, Ping Robert Aug 2023

International Doctoral Student Experiences In Educational Administration Programs In The United States: A Phenomenological Study, Ping Robert

Electronic Theses and Dissertations

Background: In recent years, more international students are enrolling in Educational Administration (EA) programs in the United States. While EA programs wish to recruit and retain international students, more research is needed on supporting international graduate students in graduate education programs and EA programs specifically. Purpose: The present phenomenological study aims to understand the experience of international doctoral students in U.S. EA programs. The present research was guided by the question: “What is the essence of international postgraduate student experiences in EA programs in the United States?” Methodology: The present study used hermeneutic phenomenology to describe and interpret data from …


The Gender And Race Intersectional Disproportionality-Tool (Grid-T): An Exploration Of Practitioners’ Access To And Use Of High-Quality Data For Special Education Placement, Audrey J. Ford Aug 2023

The Gender And Race Intersectional Disproportionality-Tool (Grid-T): An Exploration Of Practitioners’ Access To And Use Of High-Quality Data For Special Education Placement, Audrey J. Ford

Electronic Theses and Dissertations

Disproportionality in special education (SPED) is upheld by systems and individuals, policies, and practices that both reflect and shape the local communities within which it exists. Even with many proposed solutions for disproportionality, it persists. This two-manuscript dissertation explores two characteristics that make disproportionality difficult to solve (e.g., inconsistent findings and persistence) and proposes a tool to inform data-based decision making in interventions for disproportionality in SPED.

Manuscript One (M1) includes a literature review and development of the Gender and Race Intersectionality Disproportionality- Tool (GRID-T). Based on the findings of the literature review about inconsistence and persistence, I crafted three …


Experience Matters: Exploring How Firms Build Dynamic Capabilities Through Execution Of The M&A Transaction Process, Chauntel R. Graves Aug 2023

Experience Matters: Exploring How Firms Build Dynamic Capabilities Through Execution Of The M&A Transaction Process, Chauntel R. Graves

Electronic Theses and Dissertations

Existing M&A and organizational learning theory research suggests the firm can develop expertise in M&A process execution with each successive M&A transaction experience. The ability to align, assimilate and exploit this learning to build acquisition capability over time aligns with the dynamic capabilities theory. This study inductively explores how the firm learns from previous acquisition experience and continuously improves its M&A process capability. While there are three dimensions of dynamic capabilities, this study focuses on the Sensing dimension – identifying opportunities and threats meeting the demands of an ever-evolving business environment. Experienced M&A professionals suggest essential factors considered consequential to …


The Struggle Is Real: Constructing Liberative Meaning Making That Facilitates Black Student’S Authentic Identity Formation And Navigation Through Predominately White Institutions, Felicia Marie George Aug 2023

The Struggle Is Real: Constructing Liberative Meaning Making That Facilitates Black Student’S Authentic Identity Formation And Navigation Through Predominately White Institutions, Felicia Marie George

Electronic Theses and Dissertations

This dissertation focuses on how Black students’ use of navigational capital reflects a quest for complex subjectivity that facilitates authentic identity formation and navigation through a private, predominantly white, four-year, R1 institution (PWI’s). A qualitative study that used portraiture methodology was conducted to collect stories of the lived experience and perceptions of two Black senior undergraduate students who attended a PWI. Their stories provided the foundation for constructing liberative meaning making (LMM), an ethic of praxis that uses a hermeneutics of listening to heighten students’ awareness of and living from interiority. The concept engages De La Torre’s theory of liberative …


Polar Body Membrane Breakdown Occurs Independent Of Macroautophagy In C. Elegans, Shruti Kolli Aug 2023

Polar Body Membrane Breakdown Occurs Independent Of Macroautophagy In C. Elegans, Shruti Kolli

Electronic Theses and Dissertations

Failure to digest cell corpses can lead to lupus-like autoimmune disorders in mammals. To better understand if LC3-associated phagocytosis (LAP) drives cell corpse breakdown in phagolysosomes, we studied the clearance of the C. elegans polar body during embryonic development. ATG16L1 has separable roles in regulating LC3 recruitment during macroautophagy and LAP. We demonstrated that the ATG16L1 C. elegans orthologs, ATG-16.1 and ATG-16.2, function redundantly to promote polar body membrane breakdown. We also discovered that truncating the LAP-specific WD40 domain of ATG-16.2 unexpectedly disrupts autophagy. Furthermore, we confirmed that polar body membrane breakdown occurs independent of macroautophagy. We also showed that …


Risk And Promotive Factors For Perinatal Mental Health Problems: Adverse And Benevolent Childhood Experiences And Contemporaneous Support And Stress, Jillian S. Merrick Aug 2023

Risk And Promotive Factors For Perinatal Mental Health Problems: Adverse And Benevolent Childhood Experiences And Contemporaneous Support And Stress, Jillian S. Merrick

Electronic Theses and Dissertations

Despite a growing body of research on childhood risk and promotive factors for perinatal mental health, as well as extensive research on adulthood risk and promotive factors for these problems, little research considers childhood and adulthood experiences alongside one another. The current study addressed this gap by examining childhood experiences, both adverse and benevolent, alongside contemporaneous sociodemographic stress and social support as predictors of depression and PTSD symptoms during pregnancy and at 3-4 months postnatal.

Participants were 175 ethnically-diverse women (M = 28.07 years, SD = 5.68, range = 18-40; 38.9% White, 25.7% Latina, 16.6% Black, 12.0% biracial/multiracial, 6.8% …


Childhood Maltreatment And Romantic Relationship Functioning During Pregnancy: Women’S Narrative Coherence About Partners And Couples’ Conflict Communication And Recovery, Laura M. River Aug 2023

Childhood Maltreatment And Romantic Relationship Functioning During Pregnancy: Women’S Narrative Coherence About Partners And Couples’ Conflict Communication And Recovery, Laura M. River

Electronic Theses and Dissertations

Childhood maltreatment (CM) is associated with difficulties in romantic relationships in adulthood, including conflict, less support, and difficulties in communication. However, little is known about the impact of CM on romantic relationship functioning in the context of pregnancy, during which time romantic relationships are highly influential for family well-being. Additionally, very limited research has been conducted on fathers’ relationship experiences after a history of CM. In a set of two papers, this dissertation examined the effects of CM on 1) pregnant women’s narrative coherence about their romantic partners and 2) couples’ (pregnant women and babies’ fathers) observed conflict communication and …


The Post-Wwii American Picaro As Prophet Of Human Dignity: A Study Of Ralph Ellison’S Invisible Man, Flannery O’Connor’S The Violent Bear It Away, And Saul Bellow’S Henderson The Rain King, Elijah Clayton Null Aug 2023

The Post-Wwii American Picaro As Prophet Of Human Dignity: A Study Of Ralph Ellison’S Invisible Man, Flannery O’Connor’S The Violent Bear It Away, And Saul Bellow’S Henderson The Rain King, Elijah Clayton Null

Electronic Theses and Dissertations

The picaro, a rascal or rogue who tells his or her life story, is an important but understudied figure in midcentury American letters. Critics of the 1960s, such as R.W.B. Lewis, often discussed the picaro and the picaresque, but recent American scholarship has not revisited the role and importance of this figure and genre.

This study employs the methodologies of historicism, formalism, and intellectual history to explain how American authors in the period after WWII used the picaro and picaresque, a figure and genre that originated in 16th century Spain, as vehicles for their explorations of the question of human …


Anxiety As A Compensatory Factor For Executive Functioning Abilities And Later Adhd Symptoms In Youth With Adhd, Rebecca Slomowitz Aug 2023

Anxiety As A Compensatory Factor For Executive Functioning Abilities And Later Adhd Symptoms In Youth With Adhd, Rebecca Slomowitz

Electronic Theses and Dissertations

Higher ADHD symptoms have been associated with reduced executive functioning (EF) performance in children. However, an emerging body of research has suggested that in children with higher ADHD symptoms, higher levels of anxiety symptoms may contribute to buffered executive functioning (EF) performance, termed a compensatory interaction. However, results investigating this hypothesis have been mixed, possibly due to the use of smaller sample sizes, cross-sectional datasets, and infrequent testing of compensatory interaction effects between ADHD and anxiety symptoms. The current study expands upon the previous literature by testing for compensatory interactions between anxiety symptoms and ADHD symptoms (e.g., inattention and hyperactive-impulsive …


Insights Into The Structural And Electronic Properties Of 2d Polar Sic/Gec Heterostructures And Asxp1−X Alloys., Kazi Jannatul Tasnim Aug 2023

Insights Into The Structural And Electronic Properties Of 2d Polar Sic/Gec Heterostructures And Asxp1−X Alloys., Kazi Jannatul Tasnim

Electronic Theses and Dissertations

Due to the unique structural and electronic properties along with the practical applications in current and near future, investigations about the group-IV graphene-like two-dimensional (2D) sheets have been accelerated. Among them, 2D SiC and GeC sheets are polar materials with in-plane charge transfer from Si (Ge) to C atoms. An interesting question is how the electrostatic force, triggered by such in-plane charge transfer, plays a role in stabilizing the vertical heterostructures formed by 2D SiC and GeC sheets beyond vdW interaction. To answer this question, we have systematically investigated, in my PhD research projects, the effects of the electrostatic interaction …


Effects Of Environmental Pollutants On Liver Disease: Role Of The Gut-Liver Axis., Ngozi Victoria Adiele Aug 2023

Effects Of Environmental Pollutants On Liver Disease: Role Of The Gut-Liver Axis., Ngozi Victoria Adiele

Electronic Theses and Dissertations

Polychlorinated biphenyls (PCBs) and polystyrene (PS) microplastics are environmental pollutants associated with various diseases including toxicant associated fatty liver disease (TAFLD). Previously, exposure to Aroclor 1260 (a PCB mixture) has been shown to exacerbate TAFLD, partly through Aroclor 1260 induced gut dysbiosis. Studies has also demonstrated that PS exposure alters gut microbiome composition and induced obesity. However, the effects of Aroclor 1260 on the gut and the effects of PS on the liver are still understudied. Therefore, we hypothesize that environmental pollutants will disrupt the gut-liver axis through changes in gut and its microbiome as well as changes in liver …


Understanding Associations Between Chronic Illness Identity, Psychological Flexibility, And Type 2 Diabetes Emotional, Behavioral, And Psychosocial Functioning., Valery Bodziony Aug 2023

Understanding Associations Between Chronic Illness Identity, Psychological Flexibility, And Type 2 Diabetes Emotional, Behavioral, And Psychosocial Functioning., Valery Bodziony

Electronic Theses and Dissertations

Introduction: Illness identity, defined as the extent to which one integrates their illness into their sense of self, may be a key psychological factor to consider in overall adjustment to and management of Type 2 Diabetes. Emerging research suggests illness identity integration is associated with aspects of diabetes-specific functioning. Psychological flexibility has also been found to be associated with positive diabetes-specific functioning. This modifiable cognitive factor may play a role in the relationship between illness identity and diabetes-specific functioning. This study aims to examine associations between illness identity enrichment, illness identity rejection, psychological flexibility, and aspects of diabetes-functioning, including self-management …


Interactive Computer-Based Simulations As Exploratory Learning Activities., Derek Mcclellan Aug 2023

Interactive Computer-Based Simulations As Exploratory Learning Activities., Derek Mcclellan

Electronic Theses and Dissertations

Typical college lectures follow a direct instruction framework, where instructors deliver a lecture, followed by an activity. Exploratory learning flips this routine by providing students with an activity prior to instruction. Research suggests that this inversion benefits students’ conceptual understanding and ability to transfer their knowledge. The majority of exploratory learning tasks in the literature are problem-solving activities. The current work investigates the use of computer-based simulations during exploratory learning, and whether manipulating the cognitive load of the activity impacts learning. In Experiment 1, undergraduate students (N=66) were randomly assigned to explore a simulation-based circuit construction activity prior …


Institutional Racism, Racial Trauma, And Mental Health In Bipoc Graduate Students And Professionals., Jody Zhong Aug 2023

Institutional Racism, Racial Trauma, And Mental Health In Bipoc Graduate Students And Professionals., Jody Zhong

Electronic Theses and Dissertations

While there is increasing mainstream focus on diversity, equity, and inclusion (DEI) amongst U.S. college campuses, institutional racism and everyday racist events continue to be common experiences for Black/Brown, Indigenous, and People of Color (BIPOC) students (Bartz, 2019; Noltemeyer et al., 2012; Pieterse et al., 2010; Regis, 2016; Vaishnav, 2020). Research has shown that subtle, everyday racist slights, known as microaggressions, can have a substantial effect on the mental health and functioning of BIPOC, leading to the development of posttraumatic stress and to negative impacts on psychological well-being (Abdullah et al., 2021; Le et al., 2021; Lui & Quezada, 2019; …


“Long Live Ear X-Tacy!”: An Oral History Study Of Rhetorics Of Nostalgia And Place., Aubrie Warner Aug 2023

“Long Live Ear X-Tacy!”: An Oral History Study Of Rhetorics Of Nostalgia And Place., Aubrie Warner

Electronic Theses and Dissertations

This study aims to explore rhetorical placemaking through how people understand and construct narratives around places that no longer exist. In doing so, it examines the relationship between nostalgia and place — how rhetorical construction of place is influenced and/or informed by rhetorics of nostalgia, how our experiences influence our sense of place (past and present), and how we create continuity for ourselves in the construction and maintenance of particular narratives. This study contributes to the emerging field of rhetorics of nostalgia and places it in direct conversation with rhetorics of place and unpacks how these two are more connected …


False Memories Are Impacted By Semantic Pairing Of Drm Lists., Ryan Coleman Aug 2023

False Memories Are Impacted By Semantic Pairing Of Drm Lists., Ryan Coleman

Electronic Theses and Dissertations

In the DRM paradigm, experience of semantically related words leads to false memories of related words called critical lures. These false memories serve as evidence that the relationship between items in a DRM list contribute to an overall gist or central concept for the experience. The present studies aim to investigate whether the higher-order semantic relationship that exists between different DRM lists can also influence recognition memory. Study 1 compared memory confidence ratings for list items and critical lures to two metrics: “Temporal Contiguity”, how closely in time lists appeared to each other at encoding, and “Semantic Distance”, the semantic …


A Machine Learning Approach To Constructing Ramsey Graphs Leads To The Trahtenbrot-Zykov Problem., Emily Hawboldt Aug 2023

A Machine Learning Approach To Constructing Ramsey Graphs Leads To The Trahtenbrot-Zykov Problem., Emily Hawboldt

Electronic Theses and Dissertations

Attempts at approaching the well-known and difficult problem of constructing Ramsey graphs via machine learning lead to another difficult problem posed by Zykov in 1963 (now commonly referred to as the Trahtenbrot-Zykov problem): For which graphs F does there exist some graph G such that the neighborhood of every vertex in G induces a subgraph isomorphic to F? Chapter 1 provides a brief introduction to graph theory. Chapter 2 introduces Ramsey theory for graphs. Chapter 3 details a reinforcement learning implementation for Ramsey graph construction. The implementation is based on board game software, specifically the AlphaZero program and its …


Stability Of Cauchy's Equation On Δ+., Holden Wells Aug 2023

Stability Of Cauchy's Equation On Δ+., Holden Wells

Electronic Theses and Dissertations

The most famous functional equation f(x+y)=f(x)+f(y) known as Cauchy's equation due to its appearance in the seminal analysis text Cours d'Analyse (Cauchy 1821), was used to understand fundamental aspects of the real numbers and the importance of regularity assumptions in mathematical analysis. Since then, the equation has been abstracted and examined in many contexts. One such examination, introduced by Stanislaw Ulam and furthered by Donald Hyers, was that of stability. Hyers demonstrated that Cauchy's equation exhibited stability over Banach Spaces in the following sense: functions that approximately satisfy Cauchy's equation are approximated with the same level of error by functions …


Statistical Inference On Lung Cancer Screening Using The National Lung Screening Trial Data., Farhin Rahman Aug 2023

Statistical Inference On Lung Cancer Screening Using The National Lung Screening Trial Data., Farhin Rahman

Electronic Theses and Dissertations

This dissertation consists of three research projects on cancer screening probability modeling. In these projects, the three key modeling parameters (sensitivity, sojourn time, transition density) for cancer screening were estimated, along with the long-term outcomes (including overdiagnosis as one outcome), the optimal screening time/age, the lead time distribution, and the probability of overdiagnosis at the future screening time were simulated to provide a statistical perspective on the effectiveness of cancer screening programs. In the first part of this dissertation, a statistical inference was conducted for male and female smokers using the National Lung Screening Trial (NLST) chest X-ray data. A …


Why Are Measures Of Depression Imperfectly Correlated? An Empirical Investigation., Eric Joseph Smith Aug 2023

Why Are Measures Of Depression Imperfectly Correlated? An Empirical Investigation., Eric Joseph Smith

Electronic Theses and Dissertations

Depression remains one of the most prevalent and impactful mental health disorders worldwide. A large number of measures of depressive symptoms are currently available, all designed to assess the same underlying construct. However, the measures tend not to correlate highly with one another. Measurement error cannot fully account for this observation, suggesting that clinical heterogeneity – that is, differences in symptom coverage across measures – might contribute to the lower-than-expected correlation between measures. We conducted two concurrent studies to examine this hypothesis. In Study 1, we developed a coding scheme to categorize items into one of 10 symptom categories. We …


Where Are All The Women?: Using Role Congruity Theory To Explore The Experiences Of Female Interscholastic Athletic Directors., Nicholas Swim Aug 2023

Where Are All The Women?: Using Role Congruity Theory To Explore The Experiences Of Female Interscholastic Athletic Directors., Nicholas Swim

Electronic Theses and Dissertations

Leadership in sport organizations continues to be male dominated, even as multiple scholars have argued and proven the importance of women holding sport leadership positions (Burton & Leberman, 2017; Darvin & Lubke, 2021; Schull, 2017). The lack of women attaining these positions leads to fewer opportunities for role modeling and mentoring experiences for female athletes. As Burden et al. (2010) argue, interscholastic athletic directors are important as they usually represent the first interactions for young athletes with people in sport leadership positions. Researchers have investigated this phenomenon at the intercollegiate level (Bower & Hums, 2013; Darvin & Lubke, 2021; Taylor …


Novel Breath Collection Techniques For Detection Of Covid-19., James Morris Aug 2023

Novel Breath Collection Techniques For Detection Of Covid-19., James Morris

Electronic Theses and Dissertations

Volatile Organic Compounds (VOC) generated endogenously in the human body can be used to detect diseases that induce oxidative stress and inflammation. Breath analysis has been used for the detection of diseases such as COPD, Depression, Lung Cancer and most recently COVID-19. Methods such as Exhaled Breath Condensate (EBC), Sorbent Tubes, Solid Phase Microextraction (SPME), and silicon microreactors have shown considerable capability in extracting and concentrating trace VOC’s present in human breath. Silicon microreactors functionalized with capture agents to derivatize carbonyl compounds are effective but the overall maximum flow rate of breath sample possible during analysis is low, making direct …


Clinical And Environmental Factors Affecting The Survival Outcomes Among Stage 1a Tn0m0 First Primary Non-Small Cell Lung Carcinoma Patients In The United States., Naiya Patel Aug 2023

Clinical And Environmental Factors Affecting The Survival Outcomes Among Stage 1a Tn0m0 First Primary Non-Small Cell Lung Carcinoma Patients In The United States., Naiya Patel

Electronic Theses and Dissertations

Background: Lung cancer is the second leading cause of death in the United States (U.S.). The most prevalent histological type of lung cancer is Non-Small Cell Lung Cancer (NSCLC), which has an overall five years survival of 5% if left untreated. Therefore, early treatment of NSCLC is vital to improve overall survival (OS) outcomes. Several factors affect survival outcomes, which can be categorized as modifiable or non-modifiable. The difference in timely receipt of guideline-concordant treatment affects the survival outcomes of patients with stage 1A NSCLC. This dissertation explored factors that affect treatment and survival outcomes among stage 1A NSCLC patients …


Statistical Methods For Assessing Treatment Effects On Ordinal Outcomes And Selecting Optimal Treatment On Survival Outcomes Using Observational Data., Huirong Hu Aug 2023

Statistical Methods For Assessing Treatment Effects On Ordinal Outcomes And Selecting Optimal Treatment On Survival Outcomes Using Observational Data., Huirong Hu

Electronic Theses and Dissertations

This dissertation consists of two projects investigating statistical methods in causal inference and personalized medication using observational data. In the first project, we propose a parametric marginal structural ordinal logistic regression model (MS-OLRM) to assess treatment effects on ordinal outcomes. Average treatment effect (ATE) is used to measure the difference of the mean outcomes if all patients would have been treated compared with the outcomes if they would not have been treated. Many statistical methods have been developed to estimate ATE when the outcome is continuous or binary. The methodology on assessing treatment effect for an ordinal outcome is less …


Intercalation And High-Pressure Investigations Of Black Arsenic Phosphorus: Unraveling Material Transformations., Dinushika Vithanage Aug 2023

Intercalation And High-Pressure Investigations Of Black Arsenic Phosphorus: Unraveling Material Transformations., Dinushika Vithanage

Electronic Theses and Dissertations

Black arsenic phosphorus (b-AsyP1-y) alloys have emerged as intriguing materials within the realm of two-dimensional (2D) materials, following the discovery of black phosphorus (BP). These alloys possess capability to overcome major limitations of BP and exhibit potential for tunability and enhancement of properties making them promising materials for a wide range of applications, including lithium-ion batteries. Inspired by the intriguing findings obtained for BP, this research focuses on understanding the structural modifications that can be achieved in b-AsyP1-y alloys through the application of intercalation and high pressure. The initial phase of our investigation …


The Relationships Between State-Level Economic Policies, Child Maltreatment, And Suicidal Behavior And Mortality., Yana B. Feygin Aug 2023

The Relationships Between State-Level Economic Policies, Child Maltreatment, And Suicidal Behavior And Mortality., Yana B. Feygin

Electronic Theses and Dissertations

Suicide has proven to be difficult to predict and prevent at the individual level,1–3 so much so that a recent analysis of individual risk assessments found a maximal positive predictive value of 5.5% for suicide death,2 and suicide continues to be a leading cause of death among adolescents age 10-19 years.4 By targeting modifiable risk factors at the population level, policy has the potential to extend our reach to people and subgroups that are missed by individual level interventions. This ecological study of adolescent suicide rates, state policies, and child maltreatment in US states from 2005-2019 and Kentucky counties from …


Swallow, Breathing And Survival: Sex-Specific Effects Of Opioids., Michael Frazure Aug 2023

Swallow, Breathing And Survival: Sex-Specific Effects Of Opioids., Michael Frazure

Electronic Theses and Dissertations

This dissertation presents a series of studies examining mechanisms of deglutition and respiration, and how these vital processes are impacted by opioids. The experiments in Chapter Two investigated the role of the upper esophagus in airway protection through systematic activation of pharyngeal and esophageal mechanoreceptors in a cat electromyography model. Chapter Three compared effects of opioid administration on breathing and swallowing between male and female rats, and found that females are more susceptible to opioid-induced depression of breathing and swallow than males. Findings from Chapters Two and Three led to the development of a translational model of opioid-induced dysphagia using …


Injury Induced Neuroplasticity And Cell Specific Targeting Of The Lumbar Enlargement For Gene Therapy., Brandon Lee Brown Aug 2023

Injury Induced Neuroplasticity And Cell Specific Targeting Of The Lumbar Enlargement For Gene Therapy., Brandon Lee Brown

Electronic Theses and Dissertations

This dissertation is an examination of spinal cord injury induced neuroplasticity and tests whether noninvasive gene therapy can successfully target neurons in the lumbar spinal cord. It begins with an overview of neural control of locomotion and a brief summary of therapeutics that are used and/or in development for treating spinal anatomically characterize s subset of neurons in the spinal cord, long ascending propriospinal neurons, that are involved in interlimb coordination. Characterization of these neurons allows for subsequent evaluation of their potential involvement in injury induced neuroplasticity. This dissertation is divided into five chapters, covering spinal cord injury and therapeutics. …


Public Space And Well-Being: An Empirical Study Of Central Park In Old Louisville., Maryam Entezam Aug 2023

Public Space And Well-Being: An Empirical Study Of Central Park In Old Louisville., Maryam Entezam

Electronic Theses and Dissertations

Urban green spaces have been receiving attention in urban planning and the health profession in the 21st century as environmental elements that contribute to well-being. This dissertation explored the relationship between green space usage and individuals’ physical, mental, and social well-being. This empirical research focused on Central Park in Old Louisville to examine how residents use the park and whether it contributes to the well-being of residents. After exploring the existing literature, I identified four well-being indices: (1) perceived health (PHI), (2) health outcome (HOI), (3) mental well-being (MWI), and (4) social well-being (SWI). Frequent Park usage is expected …


Aurka Inhibition-Based Combination Therapy Approaches In Glioblastoma., Muge Sak Aug 2023

Aurka Inhibition-Based Combination Therapy Approaches In Glioblastoma., Muge Sak

Electronic Theses and Dissertations

Glioblastoma is the most common and aggressive central nervous system tumor in adults with a 6% survival rate. Decades of research for improving life expectancy and quality of life have been ineffective. The discovery of better treatment strategies is urgent to improve the survival rates for glioblastoma patients. Aurora Kinase A is a regulator of tumor progression and is overexpressed in glioblastoma. We used a specific Aurora Kinase A inhibitor alisertib in combination with DNA-damaging platinum agent carboplatin or brain-penetrating taxane TPI 287. We investigated the efficacy of these combinations in treating in vitro and in vivo tissue culture models …