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The Efficacy Of An In-Vivo Chaining Procedure Compared To Pov-Vm Chaining Procedure To Teach A Task To Children With Autism, Elaine M. Turner Aug 2017

The Efficacy Of An In-Vivo Chaining Procedure Compared To Pov-Vm Chaining Procedure To Teach A Task To Children With Autism, Elaine M. Turner

Electronic Theses and Dissertations

Autism Spectrum Disorder (ASD), is a neurodevelopmental disorder which includes symptoms such as repetitive or restricted patterns of behavior, and deficits in social communication (American Psychiatric Association, 2013) and affects approximately 1 in 68 children (Centers for Disease Control and Prevention, 2012). Children with this disorder face unique challenges when it comes to learning academic and social skills (Gardner & Wolfe, 2013). Chaining is an effective intervention for teaching individuals with disabilities a variety of skills (Cuvo, Leaf, & Borakove, 1978; Horner & Keilitz, 1975; Shrestha, Anderson, & Moore, 2013; Tarbox, Madrid, Aguilar, Jacobo, & Schiff, 2009). Video modeling, where …


Uses Of The Hypergeometric Distribution For Determining Survival Or Complete Representation Of Subpopulations In Sequential Sampling, Brooke Busbee Aug 2017

Uses Of The Hypergeometric Distribution For Determining Survival Or Complete Representation Of Subpopulations In Sequential Sampling, Brooke Busbee

Electronic Theses and Dissertations

This thesis will explore the hypergeometric probability distribution by looking at many different aspects of the distribution. These include, and are not limited to: history and origin, derivation and elementary applications, properties, relationships to other probability models, kindred hypergeometric distributions and elements of statistical inference associated with the hypergeometric distribution. Once the above are established, an investigation into and furthering of work done by Walton (1986) and Charlambides (2005) will be done. Here, we apply the hypergeometric distribution to sequential sampling in order to determine a surviving subcategory as well as study the problem of and complete representation of the …


Vertex Weighted Spectral Clustering, Mohammad Masum Aug 2017

Vertex Weighted Spectral Clustering, Mohammad Masum

Electronic Theses and Dissertations

Spectral clustering is often used to partition a data set into a specified number of clusters. Both the unweighted and the vertex-weighted approaches use eigenvectors of the Laplacian matrix of a graph. Our focus is on using vertex-weighted methods to refine clustering of observations. An eigenvector corresponding with the second smallest eigenvalue of the Laplacian matrix of a graph is called a Fiedler vector. Coefficients of a Fiedler vector are used to partition vertices of a given graph into two clusters. A vertex of a graph is classified as unassociated if the Fiedler coefficient of the vertex is close to …


An Examination Of The Workloads And The Effectiveness Of An Athlete Monitoring Program In Ncaa Division I Men's Soccer, Matthew L. Sams Aug 2017

An Examination Of The Workloads And The Effectiveness Of An Athlete Monitoring Program In Ncaa Division I Men's Soccer, Matthew L. Sams

Electronic Theses and Dissertations

The purposes of this dissertation were to examine common athlete training and monitoring practices in men’s collegiate soccer and to report the programming strategies and monitoring outcomes for an NCAA Division I men’s collegiate soccer team whose coaching and sport science staff collaborated on a daily basis. The following are the major findings of the dissertation:

Study 1 – Coaches from all divisions of play responded to a custom survey. A majority of coaches developed an in-season training plan that varied both daily and weekly volume and intensity. One-third of the coaches performed no athlete monitoring, and a number of …


Mirna Expression Changes In Arsenic-Induced Skin Cancer In Vitro And In Vivo., Laila Al-Eryani Aug 2017

Mirna Expression Changes In Arsenic-Induced Skin Cancer In Vitro And In Vivo., Laila Al-Eryani

Electronic Theses and Dissertations

Arsenic is a naturally prevalent metalloid. Chronic arsenic ingestion through drinking water causes skin cancer. Arsenic-induced cancer mechanisms are not well defined. Epigenetic changes, including microRNA expression changes, might be playing a role. This dissertation investigates the impact of miRNA expression changes in arsenic-induced skin cancer. MiRNA expression was measure and compared using 3 different techniques, RTq-PCR, hybridization arrays and RNA-sequencing. MiRNAs differential expression in skin lesions was phenotype- and stage-related. Immortalized human keratinocytes (HaCaT) were transformed by chronic low arsenite exposure serving as a model for arsenic-induced skin carcinogenesis. Early changes in miRNAs and target mRNAs contribute to arsenic-induced …


Examining The Effects Of Trait Rumination On Hostile Attribution Bias, Kyle A. Suhr Aug 2017

Examining The Effects Of Trait Rumination On Hostile Attribution Bias, Kyle A. Suhr

Electronic Theses and Dissertations

Previous research supports the idea that individuals high in trait anger tend to experience more hostile attribution bias. According to the Integrative Cognitive Model, cognitive factors, such as rumination, may increase the risk of hostile attribution bias and any subsequent aggressive behaviors. Sex differences are apparent in rumination and anger expression. The present research explored the potential role trait rumination plays in hostile attribution bias as well as potential conditional effects of sex on this relationship. Participants were asked to complete a number of self-report measures and vignettes of ambiguously hostile situations adapted to improve reliability. Hypotheses were largely supported …


Faces, Locations, And Tools: A Proposed Two-Stimulus P300 Brain Computer Interface, Marissa R. Jones Aug 2017

Faces, Locations, And Tools: A Proposed Two-Stimulus P300 Brain Computer Interface, Marissa R. Jones

Electronic Theses and Dissertations

Brain Computer Interface (BCI) technology can be important for those unable to communicate due loss of muscle control. The P300 Speller allows communication at a rate up to eight selections per minute. Given this relatively slow rate of communication highly accurate classification is of great importance. Previous studies have shown that alternative stimuli (e.g., faces) can improve BCI speed and accuracy. The present study uses two new alternative stimuli, locations and graspable tools in a two-stimulus paradigm. Functional MRI studies have shown that images of familiar locations produce brain responses in the parahippocampal place area and graspable tools produce brain …


A Novel Method For Synthesis Of Hydroxytyrosol, Emmanuel Onobun Aug 2017

A Novel Method For Synthesis Of Hydroxytyrosol, Emmanuel Onobun

Electronic Theses and Dissertations

Hydroxytyrosol, 3,4-dihydroxyphenolethanol, a naturally occurring polyphenol most common in olive tree (Olea europaea), is one of the most effective member of the polyphenols family, because of its remarkable antioxidant activity, its ability to inhibit oxidation of low density lipids (LDL), and its protection against DNA oxidative damage. Hydroxytyrosol, which is widely used in cosmetics and food supplements industries, can be purchased as an olive oil extract that contains low concentration of hydroxytyrosol besides other polyphenols. The price and low natural abundance of hydroxytyrosol make alternative synthetic sources very attractive. In this research, a novel method for the synthesis of pure …


Exploring The Relationship Between Physical Activity And Executive Function In Early Childhood Populations: An Investigation Of Maternal Encouragement Of Activity, Lauren P. Driggers-Jones Aug 2017

Exploring The Relationship Between Physical Activity And Executive Function In Early Childhood Populations: An Investigation Of Maternal Encouragement Of Activity, Lauren P. Driggers-Jones

Electronic Theses and Dissertations

Researchers have found positive associations between physical activity and executive function in adolescence and adulthood. However, research in early childhood has revealed only negative relationships. In the present study, I explored whether maternal encouragement of physical activity might moderate this relationship in very young children. Using video recordings from an archival dataset, eight maternal encouragement measures were derived from mother-child free play sessions. Although it was expected that maternal encouragement of child activity would broadly play a moderating role in the relationship between children’s physical activity and their executive function, only maternal questions seemed to moderate this relationship. One explanation …


A Phenomenological Study On The Motivating Factors Influencing Participation In Tennessee’S Governor’S Academy For School Leadership, Amy B. Horton Mrs. Aug 2017

A Phenomenological Study On The Motivating Factors Influencing Participation In Tennessee’S Governor’S Academy For School Leadership, Amy B. Horton Mrs.

Electronic Theses and Dissertations

Educational administration is such a demanding field, so it is important to understand why an aspiring principal would self-select to commit to an optional yearlong, intensive professional development activity with very little compensation and no promotion. Motivation may prove to be a key component of the recruitment and sustainability of professional development activities. By discovering the factors affecting both personal and professional motivation of beginning administrators to participate in a professional development led by the collaboration among the Tennessee Department of Education, Vanderbilt University, and Governor Bill Haslam, the researcher hopes to gain an understanding that may apply to future …


Evaluating A Stepped Care Protocol For Postpartum Depression In A Pediatric Primary Care Clinic, Sarah C. Smith Aug 2017

Evaluating A Stepped Care Protocol For Postpartum Depression In A Pediatric Primary Care Clinic, Sarah C. Smith

Electronic Theses and Dissertations

Postpartum depression (PPD) is a prevalent, complex illness impacting 10% to 20% of mothers and their families. Treatments for PPD, such as medication and psychotherapy, are effective at reducing the severity of symptoms and generally improving quality of life for new mothers and their families. Unfortunately, many mothers with PPD go unrecognized due to a lack of standardized screening methods. Further, mothers regularly encounter barriers to accessible, evidence-based follow-up care to treatment even when symptoms of PPD are detected. The use of a stepped care protocol, set in a pediatric primary care clinic, is one proposed strategy to address the …


Putnam County, Tennessee’S Prekindergarten Program As Measured By Test Scores, Gpa, Attendance, And Discipline Reports In 3rd, 7th, And 9th Grade, Christopher J. Winningham Aug 2017

Putnam County, Tennessee’S Prekindergarten Program As Measured By Test Scores, Gpa, Attendance, And Discipline Reports In 3rd, 7th, And 9th Grade, Christopher J. Winningham

Electronic Theses and Dissertations

The purpose of this quantitative study was to determine if there is a significant difference in the academic and behavioral performance of students who had attended Putnam County’s prekindergarten program and students who qualified for, but had not attended Putnam County’s prekindergarten program. The researcher examined individual student data of specific students in three grade bands (elementary, middle, and high school). The grade levels included 3rd grade, 7th grade, and 9th grade. The data analyzed were students’ individual GPA, ACT Explore scores, MAP Universal Screener scores, number of days absent, and number of discipline referrals of students who had attended …


Homework Practices: Teacher And Parent Perceptions Of Efficacy And Purpose, Christy E. Hoeke Aug 2017

Homework Practices: Teacher And Parent Perceptions Of Efficacy And Purpose, Christy E. Hoeke

Electronic Theses and Dissertations

The purpose of this study was to explore teacher and parent perceptions of homework effectiveness and homework purpose. Specifically, the researcher examined teacher and parent perceptions, perceptions of teachers in different grade level bands, and perceptions of teachers with different levels of experience. In this nonexperimental quantitative study, the researcher examined and analyzed the answers provided on an anonymous survey (Appendix A) provided electronically to educators and parents of students in five school systems in northeast Tennessee.

Parents had a higher perception of both homework effectiveness and homework purpose. Homework effectiveness was perceived as higher by the “other” group (not …


Perceived Value Of Higher Education Among Police Officers, Bradley D. Edwards Aug 2017

Perceived Value Of Higher Education Among Police Officers, Bradley D. Edwards

Electronic Theses and Dissertations

The purpose of this study was to examine whether police officers perceive higher education to be important in improving their job performance and promotional opportunities, whether the perception of higher education varied by several independent variables, and the types of suggestions that officers might have for improving the college curriculum. Independent variables included gender, age, level of education, type of police agency, academic major, years of service as a police officer, and job duty. The dependent variable was scores on 3 dimensions: general attitude toward higher education, perceived utility of a criminal justice related degree, and career-related competencies.

A 34- …


Opal Clark On Directing Stop Kiss An Exploration Of The Directorial Process, Opal Clark Aug 2017

Opal Clark On Directing Stop Kiss An Exploration Of The Directorial Process, Opal Clark

Electronic Theses and Dissertations

The intent of this thesis and thesis project was to execute a successful run of the play, Stop Kiss by Diana Son while achieving the playwright’s intended message. Opal Clark directed this production of Stop Kiss at East Tennessee State University under special arrangement with Dramatists Play Service, Inc. It was performed to sold out audiences in ETSU Theatre and Dance Studio 205 October 2-7, 2017. The play explores experiences and hostility toward same sex couples, their relationships with one another and how one individual discovers sexuality. The discovery and actualization of the characters’ struggles were communicated in the play …


Role Of Tlrs, Hippo-Yap1 Signaling, And Micrornas In Cardiac Repair And Regeneration Of Damaged Myocardium During Ischemic Injury, Xiaohui Wang Aug 2017

Role Of Tlrs, Hippo-Yap1 Signaling, And Micrornas In Cardiac Repair And Regeneration Of Damaged Myocardium During Ischemic Injury, Xiaohui Wang

Electronic Theses and Dissertations

Cardiovascular disease is a leading cause of death in the United States. Toll-like receptor (TLR)-mediated pathways have been demonstrated to play a role in myocardial ischemia/reperfusion (I/R) injury. We and others have shown that PI3K/Akt signaling is involved in regulating cellular survival and protecting the myocardium from I/R induced injury. In this dissertation, we provide compelling evidence that miR-125b serves to “fine tune” TLR mediated NF-kB responses by repressing TNF-a and TRAF6 expression. We constructed lentiviral expressing miR-125b, delivered it into the myocardium. The data showed that delivery of lentivirus expressing miR-125b significantly reduces myocardial infarct size and improves cardiac …


Teacher Perceptions Of The Effectiveness Of The Response To Intervention Framework With English Learners, Donna Stapleton Aug 2017

Teacher Perceptions Of The Effectiveness Of The Response To Intervention Framework With English Learners, Donna Stapleton

Electronic Theses and Dissertations

The purpose of this qualitative case study was to examine teacher perceptions of the effectiveness of the Response to Intervention (RtI) framework with students who are acquiring English as a second language.

Students from culturally and linguistically diverse backgrounds have been disproportionately represented in special education programs for decades (Artiles & Trent, 1994; Donovan & Cross, 2002; Heller, Holtzman, & Messick, 1982). Legislators responsible for the authorization of the Individuals with Disabilities Improvement Act in 2004 (IDEIA 2004) allowed state education leaders the option to use RtI as an alternative identification method. RtI was believed to be a framework through …


Enemy Exacerbation: Effects Of Predator Stress On Sulfate Lethality In Freshwater Amphipods (Gammarus Minus), Trevor Chapman Aug 2017

Enemy Exacerbation: Effects Of Predator Stress On Sulfate Lethality In Freshwater Amphipods (Gammarus Minus), Trevor Chapman

Electronic Theses and Dissertations

Predator cues can influence how aquatic organisms respond to anthropogenic contaminants. This study examined the effects of predator cues on behavior, metabolic rate, and sulfate (as Na2SO4) toxicity in amphipods (Gammarus minus). Predator cues included alarm cue (macerated conspecifics) and kairomone from mosquitofish (Gambusia affinis). Amphipods decreased activity and increased time in refuge when exposed to alarm cue, and increased time in refuge when exposed to kairomone. While median lethal concentrations (96-h LC50) were not influenced by predator cues, analysis of dose response curves indicated that kairomone exposure increased amphipod …


The Perceptions Of Father Involvement In Elementary Schools, Myles J. Hebrard Aug 2017

The Perceptions Of Father Involvement In Elementary Schools, Myles J. Hebrard

Electronic Theses and Dissertations

The purpose of this phenomenological study was to understand the perceptions of father involvement in elementary schools. The focus of the study was to allow the researcher to develop a greater understanding of perceptions of father involvement, from both a father and teacher perspective. Data was collected from teachers and fathers through surveys and interviews. Specific content areas of the father survey included communication, activities fathers engaged in, training opportunities provided at the school, parent conferences, when events were offered, availability, and suggestions for school staff. Specific content areas of the teacher survey included communication, activities fathers engaged in, training …


Early Childhood Adversity And Chronic Illness: An Examination Of A High Risk- Forensic Inpatient Population, Courtney L. Cook Aug 2017

Early Childhood Adversity And Chronic Illness: An Examination Of A High Risk- Forensic Inpatient Population, Courtney L. Cook

Electronic Theses and Dissertations

Individuals exposed adverse childhood experiences (ACEs) are at increased risk of developing chronic illnesses in adulthood including heart disease, cancer, diabetes, and chronic pain. A relationship between ACEs and health risk factors contributing to chronic disease such as smoking, obesity, and sedentary lifestyle has also been established in prior literature. There is evidence that higher that individuals in forensic inpatient mental health samples are disproportionally exposed to ACEs, which may increase odds of chronic disease development. Despite this evidence, little research has examined the prevalence of ACEs and relationships between ACEs and chronic health conditions and risky health behaviors in …


Cultivar, Season Extension, Fertilizer Trials Of Swiss Chard And Pedagogy Of Assessing Cultivars Using Technology, Chanelle Angeny Aug 2017

Cultivar, Season Extension, Fertilizer Trials Of Swiss Chard And Pedagogy Of Assessing Cultivars Using Technology, Chanelle Angeny

Electronic Theses and Dissertations

Abstract. Diversity of species is a cornerstone of horticulture, and the constant stream of new plant cultivars broadens the palette of options available to the industry. Fifteen Swiss chard (Beta vulgaris var. cicla) cultivars were evaluated during the fall/winter of 2014-2015 season (season 1) and 27 cultivars during the fall/winter of 2015-2016 season (season 2) to determine the best performing cultivars for production and landscape use for east Texas and the southeast by assessing survivability and yield. There was an increase in production of 3.0 ± 0.5 g per plant per harvest under the low tunnel. The cultivar …


A Qualitative, Exploratory Case Study Of Self-Reported Influences Affecting The Decision Of Homeless Sexual-Minority Students To Leave Home, Michael P. Hill Aug 2017

A Qualitative, Exploratory Case Study Of Self-Reported Influences Affecting The Decision Of Homeless Sexual-Minority Students To Leave Home, Michael P. Hill

Electronic Theses and Dissertations

This study was designed to identify commonalities regarding influences within the decision-making process that attributed to sexual-minority students voluntarily or involuntarily becoming homeless in lieu of remaining in their respective familial home. An exploratory case-study research design was utilized to determine common themes present in the self-described events that led up to the respective decisions of three volunteer participants, who identified themselves as sexual-minority youths at the time of transition, to leave home. Results of this study discerned five commonalities among the participants’ experiences, which influenced their experiencing homelessness. The detection of these commonalities may provide school administrators and other …


Algorithms For Automated Assignment Of Solution-State And Solid-State Protein Nmr Spectra., Andrey Smelter Aug 2017

Algorithms For Automated Assignment Of Solution-State And Solid-State Protein Nmr Spectra., Andrey Smelter

Electronic Theses and Dissertations

Protein nuclear magnetic resonance spectroscopy (Protein NMR) is an invaluable analytical technique for studying protein structure, function, and dynamics. There are two major types of NMR spectroscopy that are used for investigation of protein structure – solution-state and solid-state NMR. Solution-based NMR spectroscopy is typically applied to proteins of small and medium size that are soluble in water. Solid-state NMR spectroscopy is amenable for proteins that are insoluble in water. In the vast majority NMR-based protein studies, the first step after experiment optimization is the assignment of protein resonances via the association of chemical shift values to specific atoms in …


Cationic Surfactant Modification And Its Impact On The Engineering Behaviors Of Montmorillonite., Mohammad Ghavami Aug 2017

Cationic Surfactant Modification And Its Impact On The Engineering Behaviors Of Montmorillonite., Mohammad Ghavami

Electronic Theses and Dissertations

This study focuses on the microstructure of organoclays after organic surfactant modifications and the potential use in geoenvironmental engineering applications including waste containment in earthen barrier, rheological control agents for drilling fluid and soil stabilization. Organoclays, or clays modified by organic matters, are often synthesized by exchanging the naturally occurring interlayer inorganic cations (e.g., Na+, Ca2+) of the clay with organic cationic surfactants. In this research, montmorillonites intercalated with two quaternary ammonium surfactants, hexadecyltrimethylammonium (HDTMA+) and bis (hydrogenated tallow alkyl) dimethyl ammonium were used as the representative organo-rich, partitioning clays. The laboratory characterization techniques including XRD, TEM and …


Dynamic Adversarial Mining - Effectively Applying Machine Learning In Adversarial Non-Stationary Environments., Tegjyot Singh Sethi Aug 2017

Dynamic Adversarial Mining - Effectively Applying Machine Learning In Adversarial Non-Stationary Environments., Tegjyot Singh Sethi

Electronic Theses and Dissertations

While understanding of machine learning and data mining is still in its budding stages, the engineering applications of the same has found immense acceptance and success. Cybersecurity applications such as intrusion detection systems, spam filtering, and CAPTCHA authentication, have all begun adopting machine learning as a viable technique to deal with large scale adversarial activity. However, the naive usage of machine learning in an adversarial setting is prone to reverse engineering and evasion attacks, as most of these techniques were designed primarily for a static setting. The security domain is a dynamic landscape, with an ongoing never ending arms race …


How Muslims Help : An Ethnography Of Muslim Voluntary Assistance For Syrian Refugees In Louisville, Ky., Irene Levy Yates Aug 2017

How Muslims Help : An Ethnography Of Muslim Voluntary Assistance For Syrian Refugees In Louisville, Ky., Irene Levy Yates

Electronic Theses and Dissertations

This thesis examines Islamic faith-based organizations’ involvement in Syrian refugee resettlement in Louisville, KY with special attention to the impact of an Islamic Relief USA community engagement grant awarded to Kentucky Refugee Ministries in 2014. A description of local Muslim community support for newly arrived refugees was constructed via participant observation and semi-structured interviews with former and current resettlement agency employees, a diverse set of Muslim community volunteers, and refugees who participate in and/or are supported by Islamic faith-based organizations. Muslim communities in Louisville approach refugee resettlement in ways that are significantly different from both resettlement agency staff and past …


Water-Soluble Pd And Pd-Alloy Nanoparticles As Catalysts In Biphasic Solvent., Shekhar Bhama Aug 2017

Water-Soluble Pd And Pd-Alloy Nanoparticles As Catalysts In Biphasic Solvent., Shekhar Bhama

Electronic Theses and Dissertations

This dissertation shows the chemical synthesis of Pd and Pd-alloy nanoparticles (NPs) and their hydrogen and thermal stabilities for applications in the homogeneous and pseudo-homogeneous catalysis of organic reactions. Mainly, this dissertation describes 1) the chemical synthesis of Pd, PdPt, PdAu and Cu-Pd core-shell NPs coated with various organic ligands (thiols, amines and citrate), with different metal compositions in different synthetic environment, 2) the stability of solutions containing various NPs in the presence of hydrogen or varying temperatures, 3) the evaluation of the catalytic activity of Pd, PdPt, PdAu and CuPd NPs for hydrogenation/isomerization of allylic alcohols, and 4) the …


Former Students Discuss Middle School Science Journalism : A Qualitative Study Of Personally Meaningful Disciplinary Writing., Marsha R. Buerger Aug 2017

Former Students Discuss Middle School Science Journalism : A Qualitative Study Of Personally Meaningful Disciplinary Writing., Marsha R. Buerger

Electronic Theses and Dissertations

This qualitative research study explores the experiences of six middle school students with science news writing (SciJourn) after they have transitioned to high school. The qualitative method of case study was used with the data analyzed through the method of constructivist grounded theory. SciJourn is a disciplinary approach to science literacy that allows students to choose and research their own topic, interact with experts in the field, construct their own knowledge, and have the opportunity to publish in an on-line science newspaper (Scijourner.org). Theoretically, this research draws on science as social practice where literacy learning is cognitively complex, is situated …


Mental Health And Substance Use Disorders And Treatment Receipt Among Pregnant Women In The United States, 2008-2014 : Trend Analysis, Likelihood Of Treatment Receipt, And Ethnic Disparities In Mental Health Treatment., Taghreed Nayel Salameh Aug 2017

Mental Health And Substance Use Disorders And Treatment Receipt Among Pregnant Women In The United States, 2008-2014 : Trend Analysis, Likelihood Of Treatment Receipt, And Ethnic Disparities In Mental Health Treatment., Taghreed Nayel Salameh

Electronic Theses and Dissertations

The purposes of this dissertation were to examine trends from 2008 to 2014 in mental health and substance use disorders and treatment receipt, and explore factors associated with treatment receipt in pregnant women aged 18-44 years in the United States. A systematic review showed that illicit drug use disorder increased in pregnant women over the past decade. Despite the increase in treatment admissions for these disorders from 1992 to 2012, the overall treatment admission rate for pregnant women remained relatively stable (4%). In a trend study, compared mental health and substance use disorders and treatment receipt across Matched groups of …


Mitochondrial Transcription Factor A'S Role In Heart Failure., George H. Kunkel Aug 2017

Mitochondrial Transcription Factor A'S Role In Heart Failure., George H. Kunkel

Electronic Theses and Dissertations

Background: An essential mitochondrial component, Mitochondrial Transcription Factor A (TFAM) is reduced within the failing heart. TFAM maintains regulatory functions of cardiomyocyte physiology and stability. Mitochondrial Transcription Factor A forms a mitochondrial nucleoid anti-oxidant structure and reduces pathophysiological abnormalities to structural and contractile proteins. Overall, this functions to physically stabilize mtDNA. Significant molecular changes such as a loss of TFAM drive pathophysiological concentrations of cytoplasmic Ca2+ and reactive oxygen species. Both of these factors induce proteolytic enzymes to degrade the physiological cardiomyocyte. In TFAMs absence, heart function deteriorates and hypertrophic expansion ensues: thereby changing the physiological myocardium to a pathological …