Digital Commons Network^™

Botanical Aphrodisiacs For Women's Health, Hayley N. Prescott

Electronic Theses and Dissertations

Female Sexual Dysfunction (FSD) affects nearly 40% of women in the United States. While males have five FDA approved drugs for ED, there is only one FDA-approved as-needed treatment for premenopausal women with acquired, generalized Hypoactive Sexual Desire Disorder (HSDD), the most prevalent FSD. The lack of approved drugs is largely due to the biopsychosocial complexity of HSDD; however, there are neurobiological underpinnings evident. Due to the lack of safe efficacious treatment options, we hypothesize that botanical species traditionally used as aphrodisiacs may be promising leads, and exert their effects via activation of melanocortin’s, an excitatory circuit implicated in sexual …

Fair Sharing Of Channel Resources In The Coexistence Of Heterogeneous Wireless Networks, Sudat Tuladhar

Electronic Theses and Dissertations

Increasing spectrum resources in cellular networks are always needed to carry the exponential data traffic growth in wireless cellular networks. Limited spectrum resources in the licensed band have necessitated Long-Term Evolution (LTE) to explore available unlicensed spectrum where an incumbent WiFi system already exists. With the deployment of Licensed Assisted Access (LAA) that utilizes Listen Before Talk (LBT) for channel access in the unlicensed spectrum along with an incumbent WiFi, the coexistence of LAA and WiFi with acceptable fairness is a major challenge. In this work, we address the issues of licensed assisted access coexisting with incumbent WiFi in an …

Abaqus Implementation Of A Hyperelastic Damage Model For Glass-Reinforced Polymers Under Shock And Impact Loading, James Stuart Fraser

Electronic Theses and Dissertations

Accurate computational modeling of the ballistic response of heterogenous materials is crucial when designing lightweight armor and protective structures. Currently, due to the structural complexity inherent in composites, this behavior is poorly understood. In the present work, a novel computational model to describe the glass fiber-reinforced polymer (GRP) response to shock and impact loadings was implemented in the commercially available Abaqus© finite element software via a VUMAT subroutine. Before damage initiation, the model utilized an experimentally-determined tetragonally-symmetric stiffness matrix for the elastic representation of the GRP. Once damage was initiated, a hyperelastic continuum damage mechanics (CDM) based model described the …

The Epistemic Obligations Of The Ideal Citizen: A Neo-Aristotelian Solution For Truth-Decay In Democratic Societies, Dakota Shane Layton

Electronic Theses and Dissertations

Contemporary democratic societies are currently encumbered by the problem of truth-decay. Truth-decay is defined as the following set of interrelated trends:

Blues Is My Business (And Business Is Good?), David N. Larson

Electronic Theses and Dissertations

This work focuses on the social, political, and economic trends that govern the blues music scene in Clarksdale, Mississippi. Clarksdale is seen as a sort of “ground zero” in the blues world, it is often referred to as, “the land where blues began.” This claim is not without merit but it is not strictly historically accurate. Many of the town’s spokespeople use euphemisms that distort the troubled history of race relations in the town and its music spaces.

This investigation centers around the economic state of the town’s tourism industry, the individuals who act as the town’s promoters, and the …

Speech Fluency Changes Following Deep Brain Stimulation Of The Subthalamic Nucleus In Parkinson’S Disease: A Meta-Analysis, Emily Morphis

Electronic Theses and Dissertations

Purpose: Speech fluency changes following deep brain stimulation are one aspect that is crucial to consider when exploring treatments for Parkinson’s disease. Deep brain stimulation, specifically of the subthalamic nucleus, has been linked to a decrease in speech fluency despite improved bodily motor control. This acquired dysfluency is referred to as “neurogenic stuttering.” The purpose of the current study is to determine the incidence and severity of speech fluency decline following deep brain stimulation in patients with Parkinson’s disease. A meta-analysis was conducted with 7 studies (239 subjects) that recorded changes in speech fluency. All studies used a quantitative assessment, …

The Impact Of Ethnicity Within The Field Of Speech-Language Pathology, Maliah Wilkinson

Electronic Theses and Dissertations

The estimated racial/ethnic diversity within the field of speech-language pathology is considered to be less than 10% despite population trends predicting that over half of the United States’ population will be identified as a racial/ethnic minority by 2044 (Projections of the Size and Composition of the U.S. Population: 2014 to 2060, 2014). The limited diversity is likely to be coupled with inclusion and equity barriers in higher education (i.e., barriers related to financial and educational demographics, graduate school preparedness/support, etc.). In the field of speech language pathology, little is known about the impact of these challenges experienced by students from …

Face Detection Using Web Images, Chris Zhao

Electronic Theses and Dissertations

The current facial recognition algorithms struggle with accuracy on real world cases. Haar cascade based algorithms are fast, but require fine tuning per image in order to achieve the best results. When tasked with images where there are multiple faces at different locations, the current algorithms seem to underreport the number of faces. This study attempts to produce a more accurate classifier through the use of taking the maximum result of multiple Haar cascade classifiers with differing parameters. To do this, a web image scraper was written to gather real world images from Google images and Flickr. These images were …

Re-Engineered Metalloproteins And Rationally Designed De Novo Peptides: Towards Artificial Hydrogenases, Pallavi Prasad

Electronic Theses and Dissertations

Metals play a crucial role in biology. Metalloenzymes perform various functions in various life sustaining processes. Global energy crisis is a major challenge that the world is facing. The depleting fossil fuels and increasing carbon footprint calls for a need of alternate clean energy sources. Researchers have been working to help alleviate this challenge for decades. Hydrogen gas comes up as a potential candidate which can be used as a biofuel in a hydrogen fuel cell. Hydrogenase is a metalloenzyme that does a two-electron reversible conversion of protons to hydrogen, making it an excellent hydrogen source. However, this native enzyme …

Going Green – The Relationship Between Medical Marijuana Policy Implementation And Opioid Prescribing Patterns, Tyler James Dunn

Electronic Theses and Dissertations

Objectives

The objectives of this dissertation are: 1) To measure the prevalence of medical marijuana use in the U.S. and to identify predictors of medical marijuana use; 2) To measure opioid prescribing patterns among Medicare beneficiaries within states following the implementation of medical marijuana policies and to compare opioid prescribing patterns among Medicare beneficiaries residing within these states compared to individuals within states without medical marijuana policies in place; and 3) To determine if racial disparities exist in the effect of medical marijuana policy implementation on opioid prescribing patterns among Medicare beneficiaries.

Methods

A retrospective secondary database analysis was conducted …

The Impact Of Blended Classroom Pedagogy On Student Gpa In A Community College Stem Course, Sarah Mattox Holt

Electronic Theses and Dissertations

America is facing a shortage of STEM workers and colleges must meet the demand by educating qualified graduates. However, attrition rates are high in STEM classes, particularly in minority groups. Blended learning has increased in popularity in higher education over recent years and has the potential to improve current teaching practices. Yet, limited research centers on the success of blended learning implemented in a community college STEM course. This quantitative research study (N=1264) was designed to evaluate student success in the blended learning environment versus traditional environment in an introductory community college biology course for science majors. The study indicated …

On Airborne Tire Wear Particles Along Roads, Labeling Microplastics With Fluorescent Dyes, Microplastics In Wastewater Treatment Plant And Beach Sand, And Microplastic-Mercury Affinity, Zhiqiang Gao

Electronic Theses and Dissertations

Microplastics (MPs) with sizes of 1 μm to 5 mm that are intentional manufactured or result from fragmentation of large plastic debris are widely recognized as a global pollutant. The distributions and concentrations of MPs in environmental and biological systems as well as their toxicity are not well understood. This dissertation details five studies providing new insight and methods on (1) the occurrence and characteristics of airborne tire wear particles (TWPs) along roads, (2) manufacturing and labeling of MPs with fluorescent dyes, (3) fate of MPs in a secondary wastewater treatment plant (WWTP) at the University of Mississippi, (4) distribution …

Interval Delivery Of 5ht2a Agonists Using Multilayered Polymeric Films, Mehjabeen Hossain

Electronic Theses and Dissertations

There is an urgent unmet medical need to develop therapeutic options for the ~50% of depression patients suffering from treatment-resistant depression, which is difficult to treat with existing psycho- and pharmaco-therapeutic options. Classical psychedelics, such as the 5HT2A agonists, have re-emerged as a treatment paradigm for depression. Recent clinical trials highlight the potential effectiveness of 5HT2A agonists to improve mood and psychotherapeutic growth in treatment-resistant depression patients, even in those who have failed a median of four previous medications in their lifetime. Moreover, microdosing could be a promising way to achieve long-term alleviation of depression symptoms without a hallucinogenic experience. …

Optimization Based Parameter And State Estimation Framework For Remote Microgrid Frequency Dynamics Modeling Using Probing Signals From Energy Storage Systems, Manisha Rauniyar

Electronic Theses and Dissertations

The primary aim of this thesis is to deliver an efficient design and selection of probing signal needed to estimate state and parameters representing the power system frequency dynamics with the proposed estimation technique in real-time with minimum computational time and cost. These test cases are designed for power system researchers that need to estimate and control analysis at the remote microgrid level. Case studies are presented that can be simulated at the transmission and distribution level in power grids, and in remote isolated microgrids where the independent system operator (ISO) has control. Increasing utilization of renewable energy sources and …

Revision Total Hip Femoral Stem Micromotion And Statistical Shape Modeling Of The Knee, William Fugit

Electronic Theses and Dissertations

The first purpose of this thesis was to compare the amount of micromotion seen in the femoral stem in a revision total hip arthroplasty between simple loading conditions and loading conditions derived from activities of daily living, through the use of experimental and computational methods. The amount of micromotion at the bone-implant interface was larger for activities of daily living, with ranges of 200μm more than the largest simple loading conditions. The second purpose of this thesis was to compare measurements of accuracy in a statistical shape model between individual bone and joint-level models, specifically for the knee. Using computational …

Design Of Human Inspired Feet For Mithra, A High-Performance Humanoid Robot, Spencer Lyle Brewster

Electronic Theses and Dissertations

This thesis explores the foot design for the new humanoid robot Mithra, with the goal to improve impact mitigation, natural gait throughout the gait cycle and balance. Using human gait parameters, a stiff aluminum foot was designed to emulate human center of pressure rollover trajectories. In addition, a 2D dynamic Finite Element Analysis (FEA) of the gait cycle was created in Abaqus to rapidly prototype foot designs. Data from the FE model provided impact forces, parameters for distal foot power evaluation and maximum lean angles. From this model a flexible nylon foot was optimized for the given design objectives. The …

An Investigation Into The Plate Fixation For Periprosthetic Femoral Fractures, Xiang Chen

Electronic Theses and Dissertations

Periprosthetic femoral fractures are the third most reason for reoperation after the total hip arthroplasty with an incident rate of approximately 6%. The Vancouver type B periprosthetic femoral fractures account for over 70% of all cases, while the sub-type B1 fracture (when the total hip stem is stable) has remained a clinical challenge due to incidences of severe complications after the standard plate-screw fixation. To seek biomechanically sound fixations for the Vancouver type B1 fracture, this dissertation developed a combined modeling and testing framework to investigate the efficacy of fixation for a Vancouver type B1 fracture using different construct lengths …

Contact Simulation For Evaluating Patient Specific Surgical Guide Stability, Vincent Nierste

Electronic Theses and Dissertations

This study proposes a novel computational method to quantify guide stability for Patient Specific Instrumentation (PSI) guides. A finite element contact model was used to analyze the final position of PSI guides on a femur across a range of loading parameters representing forces applied by a surgeon during operative use. Separate segmentation methods were used for the guide and bone geometry to represent differences between segmentation and actual patient geometry. The region of loading parameters over which the guide exhibited a consistent final position was measured and reported as Guide Stability Score. The model was verified using cadaver specimens for …

Formulation, Structure, And Applications Of Therapeutic, Amino Acid, And Water-Based Deep Eutectic Solvents, Md Sajjadur Rahman

Electronic Theses and Dissertations

In the design of greener chemicals, deep eutectic solvents (DESs) are considered as one of the most versatile alternative solvents with widespread applications. DESs have the advantages of being nonflammable with negligible vapor pressure compared to traditional solvents. They share many characteristics of ionic liquids, but DESs are cheaper to formulate, typically nontoxic, recyclable, biodegradable, and are suitable for use with biological systems. In my Ph.D. research, three types of emerging and unconventional types of DESs, namely therapeutic DES (THEDES), amino acid-based DES (AADES), and water-based DES (WDES), have been investigated. To formulate these DES easily available and cheaper chemicals, …

A Non-Reacting Passive Scalar Comparison Of Starccm And Openfoam In A Supersonic Cavity Flame Holder, Thomas Nuese

Electronic Theses and Dissertations

The scramjet engine equipped with a modern-day airliner would allow for very quick travel across the United States. The major problem is that designing such an engine and testing it to make sure it is safe would cost millions if not billions of dollars. Computational fluid dynamics allows for complex designs to be tested but can still take many days, weeks, or even months to complete. With the use of computational fluid dynamics (CFD), the scramjet engine can be analyzed to determine a quicker way to test and develop a reliable configuration in addition to analyzing the effects of different …

Repairable Precast Bridge Bents For Seismic Events, Kallan Hart

Electronic Theses and Dissertations

Concrete bridge columns are designed to withstand earthquakes by undergoing large displacements. Current seismic bridge codes guarantee collapse prevention, but damage to concrete and longitudinal reinforcement often requires demolition of the structure. Repairable detailing and advanced bridge construction connections may be utilized in concrete bridge columns to allow for quick construction as well as replacement of damaged reinforcement after an earthquake. This detailing may be an attractive alternative to bridge owners to reduce construction and replacement costs as well as ensure the functionality of critical routes after an earthquake. Three repairable precast bridge columns with exposed longitudinal reinforcement were tested …

Study On Performance Of Pruned Cnn-Based Classification Models, Mengling Deng

Electronic Theses and Dissertations

Convolutional Neural Network (CNN) is a neural network developed for processing image data. CNNs have been studied extensively and have been used in numerous computer vision tasks such as image classification and segmentation, object detection and recognition, etc. [1] Although, the CNNs-based approaches showed humanlevel performances in these tasks [2], they require heavy computation in both training and inference stages, and the models consist of millions of parameters. This hinders the development and deployment of CNN-based models for real world applications. Neural Network Pruning and Compression techniques have been proposed [3, 4] to reduce the computation complexity of trained CNNs …

Impact Of Natural Cheese Composition On Proteolysis And Its Effects On Process Cheese Functionality, Natasha Scherber

Electronic Theses and Dissertations

Cheddar cheese is a commodity and a top-selling cheese in the United States. Enhanced flavors of cheddar cheese requires aging, which will allow proteolysis increase. Proteolysis is the most complex process that happens in cheese manufacturing and can be difficult to control because of environmental factors and compositional characteristics. The ripening process, which is the most timely and costly procedure in cheese manufacturing, can also be unpredictable when aspects, such as cheese composition, are changed. The coagulant is responsible for the first stage in proteolysis, which will produce large peptides. Small peptides are subsequentially produced during the second stage by …

Prairie Cordgrass Cellulose: A Sustainable Resource To Develop Biodegradable Films, Mominul Hoque

Electronic Theses and Dissertations

Plastics are versatile and cost-effective materials with a wide variety of functionalities. Their non-biodegradability, however, is an environmental concern. Plastic waste accumulation in landfills and natural habitats results in health issues, mainly due to the leaching of chemicals from plastic products that further transfer to humans and wildlife. Many countries around the globe have imposed restrictions on plastic use. Despite these concerted efforts, a pressing scientific need exists to find an alternative to plastics. Cellulose from abundant agricultural biomass stands out as a viable alternative due to its robust structure, biocompatibility, biodegradability, low density, and non-toxicity. This research aims to …

Cgrp-Driven Lateralization Of Pain Modulation By The Central Amygdala, Heather Allen

Electronic Theses and Dissertations

The central amygdala (CeA) is a bilateral, mid limbic brain region involved in the processing of pain and emotion. Interestingly, the left and right CeA are functionally lateralized in the context of bladder pain, with the left and right CeA having opposing effects on bladder pain-like behavior. However, the specific mechanisms driving these divergent functions are unknown. Nociceptive signals from the bladder are relayed to the CeA via projection neurons in the parabrachial nucleus (PBN) that express high levels of calcitonin gene-related peptide (CGRP). In these studies, we investigated the influence of PBN CGRP signaling in the left and right …

Loneliness, Interpersonal Goals, Life Satisfaction, And Subjective Well-Being In Older Adults, Francesca C. Ezeokonkwo

Electronic Theses and Dissertations

Background: Loneliness is detrimental to health and is linked to numerous physiological and psychological problems. People across the age spectrum can be affected by loneliness at one point or another in their lives; however, older adults are disproportionally affected.

Aims: This study investigated the effect of interpersonal goals (compassionate and self-image goals), life satisfaction, and subjective well-being on loneliness in older adults and the influence of demographics and social support. The Ecosystem-Egosystem Theory of Social Motivation served as the theoretical framework.

Design and Method: This descriptive cross-sectional correlational study used the 2016 Health and Retirement Study. Participants were 65 years …

Design And Synthesis Of Fused Pyrimidines As Single Agents With Combination Chemotherapy Potential, As Tubulin Polymerization And One-Carbon Metabolism Inhibitors For Cancer, Tasdique Quadery

Electronic Theses and Dissertations

This dissertation describes the design, synthesis, and biological evaluation of bicyclic fused pyrimidines as single agents with combination chemotherapy potential with both antiangiogenic and cytotoxic effects. The dissertation also discusses one-carbon metabolism inhibitors and tumor targeting proteolysis targeting chimeras (PROTACs).

In cancer chemotherapy, the two major limitations are the dose-limiting toxicities of clinically used agents and the development of resistance to the treatment. Combination chemotherapy with antiangiogenic agents and microtubule targeting agents has shown an advantage against both these drawbacks. Single agents with both antiangiogenic activity and cytotoxicity would afford a therapy that circumvents pharmacokinetic problems of multiple agents, avoid …

Real-Time Monitoring Of Cell Death Progress Using Capacitance Spectroscopy, Suyang Wu

Electronic Theses and Dissertations

Biologics, including the monoclonal antibody (mAb), has experienced rapid development in the last decade. However, the price of biologics is often prohibitively high because of the low process efficiency. Delaying the inevitable cell death improves the productivity of upstream bioprocessing, whose success relies on monitoring the cell death onset that indicates the timing for preventive actions.

This study proposes to develop a real-time monitoring model that quantifies the dying cell percentage in lab-scale bioreactors using capacitance spectroscopy. The capacitance spectroscopy contains cell death-related information due to various physical properties changes during the cell death process, e.g., cytoplasmic conductivity change. The …

Detecting Viral Particles In Vitro Using Photoacoustic Flow Cytometry, Anie-Pier Samson

Electronic Theses and Dissertations

The Covid-19 pandemic is a powerful example of just how damaging the rapid spread of an unknown virus can be. Viruses have the ability to spread rapidly amongst individuals if not treated and controlled. The first key step towards treatment is the timely and specific diagnosis of the virus causing the infection. An innovative method for the rapid detection of viral particles in solution consists of tagging the viral particles paired with using photoacoustic flow cytometry to irradiate the particles and get a signal. The high affinity of Streptavidin for Biotin can be used to bind Streptavidin-coated microspheres to biotinylated …

Analysis Of Spore Shape Determination In Streptomyces, Ning Sun

Electronic Theses and Dissertations

Streptomycetes are Gram-positive, soil-dwelling bacteria that possess a complex life cycle with the alternation of vegetative mycelium, aerial mycelium, and spores. Streptomyces. coelicolor spore maturation is a complex process that involves spore shape metamorphosis from cylindrical pre-spores into ellipsoid spores, but the details of this process have remained enigmatic. Previously, our lab identified a novel gene ssdA that might play a role in spore shape determination using a transposon-based insertion mutagenesis in S. coelicolor. In this study, I isolated a S. coelicolor ssdA-null mutant that showed increased colony hydrophobicity and misshapen spores in sizes and shapes, confirming the …