Digital Commons Network^™

A Fragile [In] Tension, Jose Homero Gutierrez, Jose Homero Gutierrez

Electronic Theses and Dissertations

The exhibition, a FRAGILE [In] TENSION, is a compilation of 6 sculptural installation works—the result of two and a half years of work in the ceramics workshop— combining various ceramic procedures, incorporating crochet techniques, and repurposed materials. Each of the materials represents specific memories of the past linked to a place of origin and people deeply attached to me, representing complementary feelings. Ceramic objects were created on the potter's wheel and subsequently joined, modified, intervened, and added to their corresponding installations following a series of self-directed design rules. The sculptures are an emotional, psychological, and physical response to the past …

A Comparison Of Logistic, Ridge, And Lasso Regression With Heart Failure Risk Data: Effects Of Sample Size, Predictor Correlation, And Predictor Weight On Outcome Accuracy, Mahmoud M. Aljuhani

Electronic Theses and Dissertations

Logistic Regression (LR), LASSO regression, and RIDGE regression are standard classification techniques for predicting a dichotomous output. Since these methods are applied for similar purposes and have different features, it is crucial to evaluate the performance of these methods under different controlled conditions. With this information, researchers can apply the optimal method for specific conditions.

Following previous research, which reported the effects of conditions such as sample size and multicollinearity on the performance of the classification methods, this research focused on the effects of when sample size, level of predictor collinearity, and predictor variable weight are controlled on the performance …

Understanding Neuroanatomy In A Virtual 3d Environment: Creation And Use Of A New Survey Tool To Evaluate The Effectiveness Of 3d Software In Neuroanatomy Education For Understanding Superficial And Deep Brain Structures., Akash Khare

Electronic Theses and Dissertations

Studying cross-sections is a critical approach to learning and testing knowledge in neuroanatomy and the role of 3D technologies have been gradually increasing in medical education, especially after the COVID-19 pandemic. A study was conducted in a quasi-experimental one-group pre-post interventional design in an online setting by creating and evaluating the effectiveness of a virtual lab in neuroanatomy for all neuroscience students enrolled in the Fundamentals of Neuroscience course in our department at the University of Louisville. Study modules were created using the 2D resources used in previous years and 3D web applications of Visible Body and AnatomyLearning.com software. A …

Ideas In Communities: A Micro-Perspective On Entrepreneurial Ecosystems., Malcolm Muhammad

Electronic Theses and Dissertations

Entrepreneurial ecosystems are seen as a stimulant of regional economic growth. Theory-building efforts on entrepreneurial ecosystems has sufficiently established an understanding of the macro-environment; the environmental infrastructure and conditions that support productive entrepreneurship. However, there has been a disproportionate lack of focus on the micro- and group-level dynamics that impact individual entrepreneurs and ventures within ecosystem. This has limited the availability of evidence to explain how and when ecosystems emerge and function at a high level. Therefore, this dissertation examines three distinct microfoundations that can be found in entrepreneurial ecosystem literature – community, learning, and venture development – to move …

Cadence And Range Of Motion Modulate Pedal Force In A Rat Model Of Motorized Cycling After Spinal Cord Injury., Gregory States

Electronic Theses and Dissertations

Motorized cycling (MC) can be utilized post-spinal cord injury (SCI) in patients who lack the strength and/or stability to participate in traditional physical exercise interventions. MC has been applied with the goal of improving locomotor function or cardiovascular health in both human and animal models of SCI. However, a discrepancy exists between the results of human and animal studies of MC, particularly regarding cardiovascular outcomes. Despite the abundance of studies in both humans and animals, the mechanism behind the improvements in cardiovascular function following MC are poorly understood. We posited that increased venous return during MC is likely due to …

Alpha, Beta-Unsaturated Aldehydes: The Underrepresented Markers Of Disease., Saurin Sutaria

Electronic Theses and Dissertations

The peroxidation of unsaturated fatty acids is a widely recognized metabolic process that creates a complex mixture of volatile organic compounds including aldehydes. Elevated levels of reactive oxygen species in cancer cells promote random lipid peroxidation, which leads to an increase in a variety of aldehydes. Many of these volatile aldehydes are exhaled and are of interest as potential markers of disease. Chapter 1 presents a review of reported aldehydes in the exhaled breath of lung cancer patients. alpha,beta-Unsaturated aldehydes, detected primarily when derivatized during exhaled breath preconcentration, are underreported in the reviewed articles. Chapter 1 concludes with our hypothesis …

Establishing The Efficacy Of Non-Cellular Components Of Adipose-Derived Stromal Vascular Fraction In Promoting Angiogenesis., Daniel Benson

Electronic Theses and Dissertations

Microvascular disease is hallmarked by pathophysiological conditions such as endothelial senescence, intimal thickening which impairs vasodilation, and regression of the capillary beds causing tissue ischemia in the myocardium or in peripheral vascular networks. Adipose-derived stromal vascular fraction (SVF) has previously demonstrated the ability to revascularize tissue. Increasing evidence shows that regenerative cells elicit their therapeutic benefit by paracrine mechanisms, leaving open extracellular vesicles (EVs) as a potential crux of the cell therapy paradigm. To test this idea, three types of gelatin methacrylate hydrogels were employed: SVF gels, EV gels derived from SVF, and blank control gels, which were used in-vitro …

Sex And The Superman: Gender And The Superhero Monomyth, Christopher Maverick

Electronic Theses and Dissertations

Since the 1938 introduction of Superman, superheroes have been ever-present in American popular culture. Indeed, with the modern preponderance of comic book movies dominating the American cinematic box-office, superhero fantasy is arguably the most important genre of fiction being produced in the contemporary moment. Peter Coogan, Kurt Busiek and many other scholars have discussed the prominence and relevance of the superhero fantasy as a genre. Still others, including Umberto Eco and Marco Arnaudo, have asserted that the superhero is not so much a genre and as it is the evolution of mythology. In Sex and the Superman, I argue …

Investigating The Pi3k/Akt/Atm Pathway, Telomeric Dna Damage, T Cell Death, And Crispr/Cas9-Mediated Gene Editing During Acute And Chronic Hiv Infection, Sushant Khanal

Electronic Theses and Dissertations

Human Immunodeficiency Virus (HIV) infection initiates major metabolic and cell- survival complications. Anti-retroviral therapy (ART) is the current approach to suppress active HIV replication to a level of undetected viral load, but it is not a curative approach. Newer and sophisticated gene editing technologies could indeed be a potent antiviral therapy to achieve a clinical sterilization/cure of HIV infection. Chronic HIV patients, even under a successful ART regimen, exhibit a low-grade inflammation, immune senescence, premature aging, telomeric DNA attrition, T cell apoptosis, and cellular homeostasis. In this dissertation, we investigated CD4 T cell homeostasis, degree of T cell apoptosis, an …

An Acute Sense Of Place: The Songs Of Norman Blake, Thomas Jutz

Electronic Theses and Dissertations

American flat-picking guitarist, singer and songwriter Norman Blake holds legendary status among guitar players, bluegrass, and folk musicians.

The aim of this research is to analyze the interaction of sense of place in Norman Blake’s songwriting. This research will explore the techniques Blake uses to create that acute sense of place. Elements of literary criticism, cultural geography, ethnomusicology, and sense of place studies, as well as historical background information on Northern Alabama and North Georgia will be employed to show how this particular region of Southeastern Appalachia has informed Blake’s songwriting.

The research questions that I aim to answer are …

Importance Of The Microhabitat And Microclimate Conditions In The Northern Gray-Cheeked Salamander (Plethodon Montanus) Across An Elevation Gradient, Trevor Chapman

Electronic Theses and Dissertations

The southern Appalachian Mountains have among the highest salamander diversity in the world, largely due to local speciation in the family Plethodontidae. Plethodontid salamanders (i.e., lungless salamanders) are particularly sensitive to habitat climate conditions due to their reliance on cutaneous respiration, and their immediate environmental conditions (microhabitat) likely influence their dispersion and activity more than the large-scale atmospheric conditions. The Northern Gray-cheeked salamander (Plethodon montanus) is restricted to high elevations in the Appalachian Mountains. Our goal was to investigate the relationship between P. montanus and its microhabitat by examining behavioral preference for climatic conditions, characterizing the microclimate with …

The Folk Festival Of The Smokies And The Role Of Music Festivals In Preserving Old-Time Music In Appalachia, Keegan Luckey-Smith

Electronic Theses and Dissertations

This thesis examines the history of the Folk Festival of the Smokies, which sought to preserve old-time music as an expression of southern Appalachian regional culture. The study uses qualitative methods, including personal interviews with one of the founders and significant festival participants, supplemented with archival and historical research into photographs, festival performances and literature regarding the festival. Since the festival operated for thirty-three years as a small festival in a relatively isolated location in eastern Tennessee, this case study serves as an example of the role of festivals in intangible cultural heritage preservation in relatively rural settings. The legacy …

Physician Quality Scores And The Presentation And Delivery Method Of Data In A Residency Program, Monaco Briggs

Electronic Theses and Dissertations

The United States health care expenditures are higher than any other developed country. Due to this, physician payment reform is moving from fee-for-service (FFS) to a value-based model, with a focus on prevention and quality. The purpose of this quantitative study was to measure the effect of a series of data delivery interventions associated with the quality scorecards and which method increased the quality scores at a medical teaching practice in Tennessee.

Data were gathered via the Physician Quality Scorecard, an internally developed instrument. Each quarter, a different data delivery intervention was performed, and scorecard data were analyzed …

Folic Acid – Carbon Dots – Doxorubicin Nanoparticles As Cancer Theranostic, Michael Tetteh

Electronic Theses and Dissertations

This work focused on engineering bi-functionalized nanoparticles (NPs) based on carbon dots (CDs) to improve early cancer detection and treatment. Therefore, using folic acid (FA) as a targeting agent, the CDs were prepared to deliver high concentrations (HC) of doxorubicin (DOX) and gemcitabine (GEM) covalently and non-covalently to cancer cells. The prepared FA-CDs-DOX/GEM-HC NPs were characterized using ultraviolet-visible spectroscopy, fluorescence spectroscopy, and Fourier transform infrared spectroscopy. Assessment of the drug loading capacity (DLC) and drug loading efficiency (DLE) indicated that the non-covalent NPs have low DLC but high DLE compared to the relatively low DLE and high DLC of covalent …

The Role Of Generative Adversarial Networks In Bioimage Analysis And Computational Diagnostics., Ahmed Naglah

Electronic Theses and Dissertations

Computational technologies can contribute to the modeling and simulation of the biological environments and activities towards achieving better interpretations, analysis, and understanding. With the emergence of digital pathology, we can observe an increasing demand for more innovative, effective, and efficient computational models. Under the umbrella of artificial intelligence, deep learning mimics the brain’s way in learn complex relationships through data and experiences. In the field of bioimage analysis, models usually comprise discriminative approaches such as classification and segmentation tasks. In this thesis, we study how we can use generative AI models to improve bioimage analysis tasks using Generative Adversarial Networks …

Differentiate Metasploit Framework Attacks From Others, Gina Liu Ajero

Electronic Theses and Dissertations

Metasploit Framework is a very popular collection of penetration testing tools. From auxiliaries such as network scanners and mappers to exploits and payloads, Metasploit Framework offers a plethera of apparatuses to implement all the stages of a penetration test. There are two versions: both a free open-source community version and a commercial professional version called Metasploit Pro. The free version, Metasploit Framework, is heavily used by cyber crimininals to carry out illegal activities to gain unauthorized access to targets.

In this paper, I conduct experiments in a virtual environment to discover whether attacks originated from Metasploit Framework are marked with …

Opinion Mining Of Bird Preference In Wildlife Parks, Isiwat Adenopo

Electronic Theses and Dissertations

Opinion Mining is becoming the fastest growing area to extract useful and insightful information to support decision making. In the age of social media, user’s opinions and discussions have become a highly valuable source to look for users preferences, likes, and dislikes.

The industry of wildlife parks (or zoos) is a competitive domain that requires careful analysis of visitor’s opinions to understand and cater for their preferences when it comes to wildlife. In this thesis, an opinion mining approach was proposed and applied on textual posts on the social media platform, Twitter, to extract the popularity, polarity (sentiment), and emotions …

Voltage-Gated Potassium Channel Dependent Mechanisms Of Cardiovascular Adaptation To Chronic Exercise., Sean Raph

Electronic Theses and Dissertations

Exercise increases cardiac workload, escalating the demand for oxygen. The myocardial vasculature responds to the greater demand for oxygen by increasing blood flow to match the needs of the heart during augmented work. Increasing blood flow requires the coronary arteries dilate (a.k.a. vasodilation); this is mediated predominantly by vascular smooth muscle cell relaxation. Vasodilation is driven through inhibition of calcium influx into vascular smooth muscle cells. The prevention of calcium influx is largely mediated by efflux of potassium via potassium channels causing membrane hyperpolarization, which in turn closes voltage-dependent (or gated) calcium channels (VDCC). Changes in vascular smooth muscle cell …

Power In Portrayal: An Exploration Of The Evolving Cold War Relationship Between Germany And America Through Film, Kaleb Wentz

Electronic Theses and Dissertations

The end of the Second World War brought many questions to the United States. One of the greatest among these was what to do with defeated Germany. Many clamored for the dissolution of the former Nazi State and the shameful humbling of its people while others recognized the value of a revitalized Germany as an ally against the looming threat of an emboldened and empowered postwar Soviet Union. Though retribution held sway immediately following the war, the Cold War consensus of an alliance with West Germany and a reimagining of the German people as victims rather than perpetrators won out …

Escape Beneath: An Original Game Score Inspired By An Analysis Of Garry Schyman's Music, Daniel Cooper

Electronic Theses and Dissertations

Video-game music has grown into a vast array of different styles, sounds, and applications. As a newer field of music, game scoring has begun to receive high acclaim. Garry Schyman has become one of the most successful composers within the video-game industry. His music has received many awards and nominations throughout the years. Despite this, research and analysis into his compositions and techniques are almost non-existent. This thesis studies his techniques within the video-game scores for BioShock, BioShock 2, BioShock Infinite, Middle Earth Shadow of War, and Torn; and then applies them into an original …

A New Direction For Public Understanding Of Science: Toward A Participant-Centered Model Of Science Engagement., Christopher Rickels

Electronic Theses and Dissertations

Engaging the public with science is not an easy task. When presented, scientific findings, public health recommendations, and other scientific information filter through the personal values, beliefs, and biases of members of the public. Science communicators must contend with these differences in order to be effective in cultivating a public understanding of science. Given the importance of scientific understanding for living well in a complex world, increasing science understanding through science engagement is imperative. The field of public engagement with science is dichotomized by a public information deficit approach and a contextualist approach. The deficit approach prizes the factual content …

Hgf-Mediated C-Met Signaling In Human Corneal Epithelial Cells., Kate Tarvestad

Electronic Theses and Dissertations

Vision is often regarded as the primary sense of humans. The cornea is the main refractive tissue that permits light through to the retina, allowing a clear image. When the cornea sustains damage, it opens a pathway for infection and blindness through fibrotic processes. Healing the corneal tissue is critical for vision restoration and pain alleviation. Growth factors and their cognate receptors are currently under investigation as tools to restore proper corneal physiology. We hypothesize that manipulating the hepatocyte growth factor (HGF)/ c-Met signaling pathway is one route to promote quality corneal healing. This thesis investigates the signaling, trafficking, and …

Models And Algorithms For Trauma Network Design., Sagarkumar Dhirubhai Hirpara

Electronic Theses and Dissertations

Trauma continues to be the leading cause of death and disability in the US for people aged 44 and under, making it a major public health problem. The geographical maldistribution of Trauma Centers (TCs), and the resulting higher access time to the nearest TC, has been shown to impact trauma patient safety and increase disability or mortality. State governments often design a trauma network to provide prompt and definitive care to their citizens. However, this process is mainly manual and experience-based and often leads to a suboptimal network in terms of patient safety and resource utilization. This dissertation fills important …

Re-Engineering Cardio-Oncology Testing Using Biomimetic Heart Slice Cultures., Jessica Miller

Electronic Theses and Dissertations

28% of drug withdrawal from the market are due to unforeseen disruptions in cardiomyocyte contractility and electrophysiology. The most commonly used platforms for drug testing are in vivo animal models and in vitro cell culture models. While both have been of paramount importance for the discovery and detection of many cardiotoxicities and mechanisms of action, they lack the ability to model an intact human myocardium. This work aims to establish cardiac tissue slices, which are 300-micron thin tissue sections taken from the left ventricular myocardium, as an alternative platform for cardio-oncology studies, specifically cardiotoxicity testing. Additionally, this work aims to …

Nonlinear Observers For Burning Zone Temperatures And Torque Estimation Of The Rotary Cement Kiln., Bhagyashri Aditya Bhagwat

Electronic Theses and Dissertations

Due to consistent expansion in the infrastructure and housing sectors worldwide have given a new way for the rapid growth of global cement market. Increased global demand for the cement production makes the attractive research topic which can lead to the quality and overall efficiency of the product. Measurement of the temperature in the burning zone is vital to maintain product quality and kiln efficiency in the cement industry. Often the BZT is un-measurable due to internal kiln conditions, dusty environment, extreme heat, harshness for example and this leads to kiln not being driven as efficient as possible. Multi-physics tools …

Anion Alloying Of Iii-V Semiconductors For Water Splitting., Sonia Calero-Barney

Electronic Theses and Dissertations

The challenge of solar energy conversion and storage translates into the discovery and development of semiconductor materials that can transform sunlight energy into electricity and/or high-energy-density fuels in a cost-effective way. From the solar energy conversion perspective, cation-alloyed III-V solar cells hold record-breaking energy conversion efficiencies, while anion-alloyed III-V’s are particularly interesting for photoelectrochemical hydrogen generation. The major challenge for the adoption of III-V-based technologies lies in the high manufacturing costs of established synthesis techniques and the difficulty to control the composition of ternary alloys. One of the materials investigated in this work is GaSb_zP_1-z. Thermodynamic …

Design, Evaluation, And Control Of Nexus: A Multiscale Additive Manufacturing Platform With Integrated 3d Printing And Robotic Assembly., Danming Wei

Electronic Theses and Dissertations

Additive manufacturing (AM) technology is an emerging approach to creating three-dimensional (3D) objects and has seen numerous applications in medical implants, transportation, aerospace, energy, consumer products, etc. Compared with manufacturing by forming and machining, additive manufacturing techniques provide more rapid, economical, efficient, reliable, and complex manufacturing processes. However, additive manufacturing also has limitations on print strength and dimensional tolerance, while traditional additive manufacturing hardware platforms for 3D printing have limited flexibility. In particular, part geometry and materials are limited to most 3D printing hardware. In addition, for multiscale and complex products, samples must be printed, fabricated, and transferred among different …

The Role Of Mri In Diagnosing Autism: A Machine Learning Perspective., Yaser Elnakieb

Electronic Theses and Dissertations

There is approximately 1 in every 44 children in the United States suffers from autism spectrum disorder (ASD), a disorder characterized by social and behavioral impairments. Communication difficulties, interpersonal difficulties, and behavioral difficulties are the top common symptoms. Even though symptoms can begin as early as infancy, it may take multiple visits to a pediatric specialist before an accurate diagnosis can be made. In addition, the diagnosis can be subjective, and different specialists may give different scores. There is a growing body of research suggesting differences in brain development and/or environmental and/or genetic factors contribute to autism development, but scientists …

Wet Chemical Synthesis And Properties Of Argyrodite Sulfide Solid Electrolytes For Solid State Lithium Batteries., William Arnold

Electronic Theses and Dissertations

The commercialization of the lithium-ion battery (LIB) in 1991 was responsible for the explosion in portable electronic technologies that has been seen over the past 30 years. With the advent of electric vehicles and other high-powered technologies, there is tremendous demand for LIBs with higher energy density and high safety. To achieve this, new electrode materials must be explored. The obvious choice of anode material would be pure metal lithium, which has a theoretical specific capacity of 3860 mAh g^-1 . Unfortunately, metal lithium anodes have not been widely commercialized due to their tendency to react violently with the …

Iot In Smart Communities, Technologies And Applications., Muhammad Zaigham Abbas Shah Syed

Electronic Theses and Dissertations

Internet of Things is a system that integrates different devices and technologies, removing the necessity of human intervention. This enables the capacity of having smart (or smarter) cities around the world. By hosting different technologies and allowing interactions between them, the internet of things has spearheaded the development of smart city systems for sustainable living, increased comfort and productivity for citizens. The Internet of Things (IoT) for Smart Cities has many different domains and draws upon various underlying systems for its operation, in this work, we provide a holistic coverage of the Internet of Things in Smart Cities by discussing …