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Further Characterization Of The Fungal Effector Mvlg-01732 In Planta And Heterologous Expression Of Fungal Effectors In Different Smut Fungi., Joseph Paul Ham Dec 2025

Further Characterization Of The Fungal Effector Mvlg-01732 In Planta And Heterologous Expression Of Fungal Effectors In Different Smut Fungi., Joseph Paul Ham

Electronic Theses and Dissertations

Host-pathogen interactions in smut fungi are characterized by effector proteins and their role in infection. The goal of this work is to better understand these interactions by further characterizing an effector from Microbotryum lychnidis-dioicae and heterologously expressing this and other effectors in heterologous species to see if the range of these effectors can play a role in pathogenicity when expressed in distantly and closely related fungal species. These effectors have been attuned over time to their host plant but have homologous interactors in other plant species. In this study, Microbotryum lychnidis-dioicae, Sporisorium reilianum, and Ustilago maydis, were all used …


Integrating Due Process Into Large Language Models., Joshua Paul Johnson Dec 2025

Integrating Due Process Into Large Language Models., Joshua Paul Johnson

Electronic Theses and Dissertations

This research investigates the ability of large language models (LLMs) to recognize due process issues. Due process is a legal concept focused on the protection of the individual during interactions with government when life, liberty, or property are being impacted. Due process presents both substantive and procedural aspects that are challenging to incorporate into generative artificial intelligence. Through assessing model performance, creating benchmarking techniques, retrieval-augmented generation (RAG), and fine-tuning, this work seeks to measure due process recognition performance and improve performance in identifying due process issues. The results of evaluating larger parameter LLMs such as from Google, Meta, and OpenAI …


The Important Of Female Coaches: What Barriers They Face, Why They Stay, And What Can Be Done To Attract More., Hayley E. Yourous Dec 2025

The Important Of Female Coaches: What Barriers They Face, Why They Stay, And What Can Be Done To Attract More., Hayley E. Yourous

Electronic Theses and Dissertations

After the passage of Title IX, there has been an increase in the number of females participating in sports; however, the same cannot translate to women in coaching or leadership positions (Acosta & Carpenter, 2014; Hart et al., 1986; LaVoi & Baeth, 2018). The purpose of this hermeneutic phenomenological study was to explore the lived experiences of females who had served as head coaches in the high school setting with at least eight years of experience as a head coach. The NCAA (2022) reported in 2020 that female coaches accounted for 41.3% of female teams' head coaches, both intercollegiate and …


Reclaiming Bodily Autonomy Through Gullah Geechee Natural Healing, Tamaray Yvonne White Dec 2025

Reclaiming Bodily Autonomy Through Gullah Geechee Natural Healing, Tamaray Yvonne White

Electronic Theses and Dissertations

In today’s sociopolitical climate, restrictive reproductive laws continue to disproportionately target Black women, reinforcing historic patterns of racialized and gendered oppression. This thesis argues that Black women will recommence their usage of traditional herbal healing as both a survival strategy and an act of reclaiming bodily autonomy in defiance of hostile legal, financial, and medical systems. The Gullah Geechee community serves as a blueprint for this transition, offering cultural continuity, intergenerational knowledge, and a model for community-based healthcare and resistance. By tracing the historical necessity of herbal medicine among Gullah Geechee women, this study situates ancestral natural healing within contemporary …


Divergent Responses Of Branched-Chain And Straight-Chain Lipid Membranes To Butanol Stress Revealed By All-Atom Molecular Dynamics Simulations, Joshua Olaf Aggrey Dec 2025

Divergent Responses Of Branched-Chain And Straight-Chain Lipid Membranes To Butanol Stress Revealed By All-Atom Molecular Dynamics Simulations, Joshua Olaf Aggrey

Electronic Theses and Dissertations

Membrane integrity under chemical stress is critical to cellular survival and industrial microbial bioproduction, yet the molecular basis of bilayer resilience remains poorly understood. Using all-atom molecular dynamics simulation, we compare the effect of increasing concentrations of 1‑butanol on membranes composed of straight-chain (1,2-dipalmitoyl-sn-glycero-3-phosphocholine, DPPC) and branched-chain (1-anteiso-palmitoyl-2-palmitoyl-sn-glycero-3-phosphocholine, APPC) lipids, which differ in the point of attachment of a single methyl group. In the absence of butanol, both membranes exhibit well-ordered architectures consistent with experimental benchmarks; however, under increasing solvent stress, their behaviors diverge markedly. DPPC membranes display gradual thinning, modest area per lipid …


From Policy To Practice: How Institutional Interpretations Of Ferpa Shape The Campus Safety Conversation, Britney Deaver Dec 2025

From Policy To Practice: How Institutional Interpretations Of Ferpa Shape The Campus Safety Conversation, Britney Deaver

Electronic Theses and Dissertations

The Family Educational Rights and Privacy Act (FERPA) is a foundational federal law designed to protect the privacy of student education records. FERPA includes exceptions—such as for health and safety emergencies—that institutions may interpret and apply in varied ways. This qualitative study explores how higher education professionals across diverse institutional contexts conceptualize and apply the health or safety exception, and how those interpretations influence campus safety practices and policy-making. Through semi-structured interviews with compliance officers and administrators, the research examines the intersection of federal policy, institutional culture, and individual judgment.

Findings reveal a range of interpretations shaped by institutional risk …


Practices To Possibility: A Narrative Inquiry Examining Practices Supporting Post-School Outcomes For Students With Disabilities, Joshua Reese Dec 2025

Practices To Possibility: A Narrative Inquiry Examining Practices Supporting Post-School Outcomes For Students With Disabilities, Joshua Reese

Electronic Theses and Dissertations

The purpose of this qualitative narrative inquiry was to examine how educators in high-performing districts that met or exceeded state targets for Individuals with Disabilities Education Act (IDEA) post-school outcomes implemented and sustained evidence-based practices to support successful transitions for students with disabilities. Despite decades of legislative mandates and educational reforms, students with disabilities continue to experience disproportionately lower rates of employment, postsecondary education, and independent living compared to their peers. This study sought to identify not only which practices are effective but also how they are operationalized and maintained within school systems.

Two Tennessee districts identified by exemplary performance …


Mass Spectrometry- And Genomic-Based Characterization Of Novel Glycosphingolipid-Producing Bacteria And Their Glycosyltransferases, Tahir Ali Dec 2025

Mass Spectrometry- And Genomic-Based Characterization Of Novel Glycosphingolipid-Producing Bacteria And Their Glycosyltransferases, Tahir Ali

Electronic Theses and Dissertations

Glycosphingolipids (GSLs) are a type of membrane-lipids commonly found in eukaryotes, as well as in bacteria from the order Sphingomonadales. In these bacteria, GSLs replace lipopolysaccharides as key structural and functional components of the outer membrane. These molecules play a crucial role in maintaining membrane integrity and helping bacteria adapt to environmental stresses. Additionally, they hold significant potential in biomedical research due to their ability to modulate the immune response through interactions with the CD1d receptor. Despite their important biological and biomedical roles, the diversity and biosynthesis of bacterial GSLs are far less understood compared to their eukaryotic counterparts. In …


Third-Person Direct-Object Anaphora In Translation From English Into Brazilian Portuguese: A Corpus-Based Study Of Juvenile Texts Reflecting Orality, Marcella Cascione Cerqueira Netto Dec 2025

Third-Person Direct-Object Anaphora In Translation From English Into Brazilian Portuguese: A Corpus-Based Study Of Juvenile Texts Reflecting Orality, Marcella Cascione Cerqueira Netto

Electronic Theses and Dissertations

The third-person accusative clitics in Brazilian Portuguese (BP) are virtually extinct in spoken language and informal writing, although formal texts and contexts still retain them. Speakers often mark third-person direct objects using the stigmatized full pronouns (syncretic with the nominative forms), null objects, or full noun phrases (NPs), also referred to as lexical NPs. The realization of these forms is not arbitrary; it is influenced by the semantic properties of the referents, particularly animacy (mainly humanness) and specificity. Animate referents [+animate] tend to be realized with overt pronouns, whereas inanimate [–animate] ones tend to be used with null objects. This …


Asking Nicely: Americans’ Perception Of Jordanian Arabic Speakers’ Politeness When Making Requests In English, David Henen Dec 2025

Asking Nicely: Americans’ Perception Of Jordanian Arabic Speakers’ Politeness When Making Requests In English, David Henen

Electronic Theses and Dissertations

This study examines how Arabic-speaking Jordanian male graduate students at an American university in Mississippi employ request directness strategies and modifications as polite devices in oral English, and how American native speakers perceive these requests. Drawing on Brown and Levinson’s (1987) Politeness Theory and the Cross-Cultural Speech Act Realization Project taxonomy (Blum-Kulka et al., 1989a, 1989b), this study employed a mixed-methods design to examine request production and perception. Data were collected from six American English native speakers from Mississippi and six Arabic-speaking Jordanian international students, all at the same university, through six discourse completion tasks, six role-plays, and semi-structured interviews. …


Southern / Appalachian Migrants And Urban Development Politics In Uptown Chicago, 1950-1972, Charles Wayne Dowdy Dec 2025

Southern / Appalachian Migrants And Urban Development Politics In Uptown Chicago, 1950-1972, Charles Wayne Dowdy

Electronic Theses and Dissertations

This thesis investigates how ideas of interregional migration were used in service of urban renewal agendas in Uptown Chicago from 1950 to 1972. It argues that The South and Appalachia as regional ideas were impactful in postwar midwestern urban development politics, even as regional identity was less powerful as an adhering force for actual migrants in comparison with factors of race and class. Chapter 1 examines the development and use of the urban enclave model of interregional migration by the Uptown Chicago Commission in the late 1950s. It argues that anxieties around suburbanization and urban decline fueled the production of …


The Relationship Between Exercise And Prospective Memory: A Meta-Analysis, Shaykhah Salman Alqahtani Dec 2025

The Relationship Between Exercise And Prospective Memory: A Meta-Analysis, Shaykhah Salman Alqahtani

Electronic Theses and Dissertations

Prospective memory (PM)—the ability to remember and carry out future intentions—is essential for everyday functioning. This cognitive process involves intention formation, retention, cue detection, and execution. Emerging research suggests that physical exercise may influence prospective memory performance through potential enhancements in attention, executive functioning, and neuroplasticity. This thesis examines the relationship between physical exercise and prospective memory through a systematic review and meta-analysis of the existing literature.

This review synthesized evidence from experimental studies to evaluate the effects of acute and chronic exercise interventions on prospective memory in diverse populations. Six studies met the eligibility criteria and were included in …


Out-Of-Pocket Costs, Treatment Pattern, And Disparities In Outcomes Among Adults With Chronic Lymphocytic Leukemia, Shishir Maharjan Dec 2025

Out-Of-Pocket Costs, Treatment Pattern, And Disparities In Outcomes Among Adults With Chronic Lymphocytic Leukemia, Shishir Maharjan

Electronic Theses and Dissertations

The purpose of this dissertation was to: 1) determine out-of-pocket cost trend and the impact of Inflation Reduction Act (IRA) provisions on the out-of-pocket costs among Medicare-enrolled chronic lymphocytic leukemia (CLL) patients; 2) evaluate treatment patterns and comparative effectiveness of therapeutics classes for CLL treatment in adults; and 3) assess racial disparities and time to treatment initiation in survival outcomes among Medicare-enrolled beneficiaries with CLL.

In objective 1, a cohort study using SEER-Medicare linked data from 2006 to 2020 identified 13,356 eligible beneficiaries with incident CLL. Among them, 3,158 (23.7%) were projected to benefit from the IRA’s $2000 annual out-of-pocket …


Visualizing The Fretboard: Arpeggiated Patterns, Muscle Memory, And Neurocognitive Strategies For The 5-String Electric Bass, Matthew Alexander Woisin Dec 2025

Visualizing The Fretboard: Arpeggiated Patterns, Muscle Memory, And Neurocognitive Strategies For The 5-String Electric Bass, Matthew Alexander Woisin

Electronic Theses and Dissertations

Proficient navigation of the 5-string electric bass requires a comprehensive mastery of various techniques and a solid understanding of music theory. This includes a detailed grasp of arpeggios, chord extensions, and the development of deeply ingrained muscle memory for precise execution. This thesis introduces a structured methodology that refines existing fretboard visualization techniques and applies a unique manner of fretboard mapping, offering a more precise framework for comprehending and unlocking the full range of the instrument. By drawing insights from music theory, music education, cognitive science, neuroscience, and technology this approach is achieved by synthesizing research on visual pattern recognition, …


Building Focus: Using Relaxation Music To Support Students With Autism In The Classroom, Whitney Drewrey Dec 2025

Building Focus: Using Relaxation Music To Support Students With Autism In The Classroom, Whitney Drewrey

Electronic Theses and Dissertations

This study explores the use of audio sensory input, specifically, relaxation music, as a strategy to reduce off-task behavior in elementary students with autism within the general education classroom. The aim was to minimize distractions and teacher redirections, thereby promoting a more inclusive and productive learning environment for all students. Guided by the principles of improvement science, the research employed a single-case design with three elementary students diagnosed with autism. Data were collected through momentary time sampling and mood inventories during independent classwork periods.

The central research question guiding this study was: What effect does relaxation music have on the …


Characterizing The Ethanol Sensitivity Of The Planar Cell Polarity Pathway In Endoderm Morphogenesis And Jaw Development., Raéden Omneil C. C. Rolle Gray Dec 2025

Characterizing The Ethanol Sensitivity Of The Planar Cell Polarity Pathway In Endoderm Morphogenesis And Jaw Development., Raéden Omneil C. C. Rolle Gray

Electronic Theses and Dissertations

Fetal Alcohol Spectrum Disorders (FASD) describes a large range of developmental defects due to prenatal alcohol exposure. It is characterized by neural and facial defects, including jaw hypoplasia. Many factors contribute to the susceptibility of ethanol-induced facial defects, including genetics, yet the genes involved, and the cell events they regulate, are poorly understood. Zebrafish have a large number of tools for genetic manipulation available, share 70% of genes with humans, are fertilized externally and are translucent during embryogenesis, making them great models to study FASD. Previous studies show that two members of the Planar Cell Polarity (PCP) pathway, zebrafish vangl2 …


The Role Of Psychological Capital And Case Management Intensity In Patient Activation In Permanent Supportive Housing Residents., Sarah J. Carter Dec 2025

The Role Of Psychological Capital And Case Management Intensity In Patient Activation In Permanent Supportive Housing Residents., Sarah J. Carter

Electronic Theses and Dissertations

This dissertation explores patient engagement with health, or patient activation, in the formerly homeless population housed in Permanent Supportive Housing (PSH) and receiving case management support. Research is limited on patient activation in PSH residents; consequently, there is minimal understanding of factors contributing to one’s attitudes and behavior towards health care in this group. Psychological Capital refers to the components of hope, self-efficacy, resilience, and optimism. Research in other marginalized groups indicates increasing psychological capital may improve health behaviors. Case management provides support to PSH residents and forms of social support have been associated with improved health outcomes. Applying the …


Branding The Divide: Political Ideology And The Strategic Challenges Of Higher Education Marketing, Oscar J. Early Mr Dec 2025

Branding The Divide: Political Ideology And The Strategic Challenges Of Higher Education Marketing, Oscar J. Early Mr

Electronic Theses and Dissertations

The purpose of this qualitative study was to explore how first-year students experience and interpret institutional branding within the context of their personal and social identities, with particular attention to the role of political ideology. While previous research had examined general branding strategies and declining public trust in higher education, scholars have given little attention to the ways in which prospective students make meaning from institutional messaging during one of the most significant transitions of their lives.

I conducted interviews with 12 first-year students from four-year colleges and universities across South-Central Appalachia. The phenomenological analysis revealed that students’ interpretation of …


A Comparative-Correlational Study On The Mental Health And Well-Being Of First-Generation Students At A Historically Black College And University, Shedred Jackson Dec 2025

A Comparative-Correlational Study On The Mental Health And Well-Being Of First-Generation Students At A Historically Black College And University, Shedred Jackson

Electronic Theses and Dissertations

The purpose of this study was to investigate the mental health and well-being of first-generation college students (FGCS) in comparison to non-first-generation college students (NFGCS) at a private Historically Black College and University (HBCU) in the Southeast. This study was undertaken to investigate students' mental health and well-being, as well as their use of, access to, and the availability of mental health services. A comparative-correlational research design was employed to collect and analyze the data. The study used a sample size of 388 responses from undergraduate college students enrolled at the private HBCU. Of the 388 students in the sample, …


A Leslie System For A Demographic Simulation: From An Actuarial Point Of View, David Kings Dec 2025

A Leslie System For A Demographic Simulation: From An Actuarial Point Of View, David Kings

Electronic Theses and Dissertations

This thesis develops a discrete stochastic linear systems interpretation of age–stage demographic evolution grounded in Leslie operators and realized in a discrete-event simulation implemented with salabim. The central claim is that one annual cycle of the simulation constitutes a cone-preserving, stochastic affine transformation on a high- dimensional population state vector indexed by age, sex, marital status, household type, employment, and education, and that the composition of yearly operators yields a random matrix product whose top Lyapunov exponent is the stochastic counterpart of the Perron–Frobenius growth rate (Caswell, 2001; Tuljapurkar, 1997)[1, 2]. The actuarial bridge is constructed by mapping simulated survival …


Perceptions Of Choral Teachers On The Characteristics Of A Secondary Choral Program, Nathan Dale Rhea Dec 2025

Perceptions Of Choral Teachers On The Characteristics Of A Secondary Choral Program, Nathan Dale Rhea

Electronic Theses and Dissertations

The purpose of this study was to examine the perceptions of choral teachers on the characteristics of a successful secondary choral program. The study focused on the main characteristics of excellence, success, and sustainability. The literature showed that there was a significant amount of research on the music curriculum, standards, and various assessment strategies but minimal research on perceptions on the characteristics of excellence, success, and sustainability of a choral music program at the secondary level.

Data collection strategies included individual interviews of eight participants who were choral music educators. The analysis of data occurred through the lens of the …


Isolation, Chemical Characterization, And In-Vitro Cytotoxic Evaluation Of Novel Polar Flavonoids From Chromolaena Leivensis, Matthew Tohatsu Tetteh Dec 2025

Isolation, Chemical Characterization, And In-Vitro Cytotoxic Evaluation Of Novel Polar Flavonoids From Chromolaena Leivensis, Matthew Tohatsu Tetteh

Electronic Theses and Dissertations

This study focuses on isolation, chemical characterization, and in-vitro cytotoxic evaluation of novel polar flavonoids from chromolaena leivensis. A 95% ethanolic extract of c. leivensis shipped by Prof. Ruben Torrenegra from University of Applied and Environmental Sciences, Bogota, Colombia, was dissolved in 1:1 methanol/chloroform mixture and its purity analyzed by TLC. The sample was eluted with toluene/methanol in an increasing order of polarity on silica gel, resulting in 49 fractions labelled CLA1 to CLA49. Among these fractions, CLA10 (1) and CLA19 (2) obtained yellow and white crystals. They were analyzed by GCMS, IR, and …


Grokking Applied To Chaotic Iterates Of The Logistic Map, Felix Donkoh Dec 2025

Grokking Applied To Chaotic Iterates Of The Logistic Map, Felix Donkoh

Electronic Theses and Dissertations

This thesis investigates grokking, the delayed transition from memorization to generalization in neural networks trained on deterministic chaotic data. Using an integer–arithmetic discretization of the logistic map, yn+1 =( a yn(p − yn))/ p 2 , bounded aperiodic sequences were generated across control parameters α ranging from 3.0 to 4.0. Transformer-based models displayed characteristic grokking curves. In periodic and chaotic regimes, validation accuracy rose suddenly after long plateaus, while at the Feigenbaum boundary (α ≈ 3.57) generalization failed completely. Increasing data diversity restored learning in chaotic domains, and explicit α–conditioning enabled a single network to generalize across all regimes. A …


Perceptions Of Practitioners: An Examination Of Practices For Retention And Support Of Special Education Teachers, Megan L. O'Dell Dec 2025

Perceptions Of Practitioners: An Examination Of Practices For Retention And Support Of Special Education Teachers, Megan L. O'Dell

Electronic Theses and Dissertations

Teacher attrition remains a critical challenge in public education, particularly among special education teachers who face unique legal, instructional, and emotional demands. This phenomenological study explored the lived experiences of current and former K–5 special education teachers to better understand the practices and resources that influence their decision to remain in or leave the profession. The central research question investigated how leadership, professional learning, and working conditions shape teacher sustainability in special education roles. Twelve participants, including six currently employed special education teachers and six who had exited the profession, participated in semi-structured interviews. Data analysis revealed five major themes: …


“War Is God” And “Unguessed Kinships”: Blood Meridian And Cormac Mccarthy’S “Border Tetralogy”, Seth Reeves Dec 2025

“War Is God” And “Unguessed Kinships”: Blood Meridian And Cormac Mccarthy’S “Border Tetralogy”, Seth Reeves

Electronic Theses and Dissertations

This thesis applies the metaphysics of philosopher Gilles Deleuze to Cormac McCarthy’s novel Blood Meridian, arguing that the novel initiates a thread of immanent subjectivity that unfolds throughout the Border Trilogy that follows it. Against a hierarchical metaphysics of transcendence, specifically an inverted Platonic Idealism, Blood Meridian dramatizes an immanent world of “optical democracy,” a prose style that levels the human and nonhuman and eludes subject and object categories. The kid’s autonomy from Judge Holden’s violent domination marks the truncated beginning of a Deleuzian subjectivity of becoming-other and immanent kinship. This incomplete gesture continues in the Border Trilogy, where …


World On Fire: The Hunger Games And The Rhetoric Of Revolution, Rachel Olivares Dec 2025

World On Fire: The Hunger Games And The Rhetoric Of Revolution, Rachel Olivares

Electronic Theses and Dissertations

In the decade between 2010 and 2020, more people participated in mass protests than at any other point in human history. From the Arab Spring to Occupy Wall Street and Hong Kong’s “umbrella movement,” street demonstrations exploded on a global scale. This period of global unrest coincided with another explosion: the dystopian young adult series The Hunger Games surged in popularity, quickly becoming a cultural phenomenon. Following the release of the book series and its subsequent film adaptations, The Hunger Games became a global symbol of grassroots resistance as social and political movements adopted the language and symbols of its …


A Qualitative Study On Black Women Leaders And Their Career Paths In Higher Education, Beatrice Porter Dec 2025

A Qualitative Study On Black Women Leaders And Their Career Paths In Higher Education, Beatrice Porter

Electronic Theses and Dissertations

Black women remain significantly underrepresented in senior leadership roles within higher education, especially in the presidency at historically Black colleges and universities. This qualitative phenomenological study explored the career paths and challenges Black women faced through their lived experiences in leadership roles across higher education institutions within predominantly White institutions and HBCUs. Guided by Black Feminist Thought as the theoretical lens, the study examined the intersecting barriers of race and gender that shaped the participants’ leadership trajectories in higher education. Data were collected through open-ended questionnaires, allowing participants to reflect on systemic inequities, mentorship experiences, and leadership development. Findings revealed …


Experiences Of Title Ix Hearing Panel Members., Amanda Gage Stonecipher Dec 2025

Experiences Of Title Ix Hearing Panel Members., Amanda Gage Stonecipher

Electronic Theses and Dissertations

The number of allegations of sexual misconduct on college campuses has been increasing over the past decade and higher education institutions are charged with addressing the misconduct. Addressing student behavior on college campuses through a conduct process is woven into the fabric of higher education, and many institutions use a hearing panel model to determine if institutional policies were violated. My research aims to explore how student conduct hearing panel members process the tension between the emotional management required when hearing intimate and traumatic details of a sexual misconduct case. The data for this research were collected via semi structured …


Symmetry, Stability, And Robust Optimization Strategies For Nonorthogonal Multiconfiguration Self-Consistent Field Wavefunctions., Zihui Song Dec 2025

Symmetry, Stability, And Robust Optimization Strategies For Nonorthogonal Multiconfiguration Self-Consistent Field Wavefunctions., Zihui Song

Electronic Theses and Dissertations

The "different orbital different configuration" (DODC) framework is a general formulation of multireference wavefunctions that allows each configuration (determinant) to possess its own set of optimized molecular orbitals, rather than sharing a common orbital basis as in conventional orthogonal configuration interaction (CI) or Complete Active Space Self-Consistent Field (CASSCF) methods. One prominent example of the DODC framework is the Nonorthogonal Configuration Interaction (NOCI) method, which relaxes the orthogonality constraint between the orbitals of different configurations. This relaxation enables a compact yet flexible description of systems exhibiting strong correlation. By employing multiple nonorthogonal reference determinants, NOCI naturally incorporates orbital relaxation and …


Characterizing Hexavalent Chromium Neurotoxicity Across Laboratory Models., Samuel Thomas Vielee Dec 2025

Characterizing Hexavalent Chromium Neurotoxicity Across Laboratory Models., Samuel Thomas Vielee

Electronic Theses and Dissertations

Hexavalent chromium [Cr(VI)] is a ubiquitous environmental pollutant and potent toxicant. Exposure to Cr(VI) in drinking water is primarily associated with cancers, inflammation, and hepatotoxicity; however, recent studies have identified Cr(VI) as a neurotoxicant in rodent and cell culture models. The literature suggest chromium accumulates in the brain, induces widespread neurodegeneration, and alters rodent behaviors. Despite these data, we lack a detailed and consistent assessments of Cr(VI) neurotoxicity across models, and interactions between aging and Cr(VI) neurotoxicity are not reported in the literature. In this dissertation, we characterize Cr(VI) neurotoxicity across 3 laboratory models: Sprague-Dawley rats, Caenorhabditis elegans, and …