Digital Commons Network^™

Classification Of Electropherograms Using Machine Learning For Parkinson’S Disease, Soroush Dehghan

Electronic Theses and Dissertations

Parkinson’s disease (PD) is a neurodegenerative movement disorder that progresses gradually over time. The onset of symptoms in people who are suffering from PD can vary from case to case, and it depends on the progression of the disease in each patient. The PD symptoms gradually develop and exacerbate the patient’s movements throughout time. An early diagnosis of PD could improve the outcomes of treatments and could potentially delay the progression of this disorder and that makes discovering a new diagnostic method valuable. In this study, I investigate the feasibility of using a machine learning (ML) approach to classify PD …

Directly Polymerizable Co Releasing Molecules, Jackson Snow

Electronic Theses and Dissertations

Despite the commonly held consensus that carbon monoxide (CO) is toxic, it has been shown to be an essential signaling molecule in the human neuronal system and has been noted to have anti-inflammatory properties, act as a vasodilator, have anti-proliferative impacts on tumors, and many other beneficial effects. The current limitation to using CO as a therapeutic molecule is delivering the proper dosages using CO releasing molecules (CORMs) without exhibiting toxicity. The first chapter of this thesis will review the biological significance of CO in biological systems, the limitations of existing CORMs, and the properties of diphenylcyclopropenone (DPCP) that make …

Lipophilic Probes For Cellular Ethylene Detection, Morgan R. Brown

Electronic Theses and Dissertations

The structure of ethylene is simple, yet its biological effects are significant. When considering its role in biology it is almost exclusively regarded as a plant hormone. Research on ethylene from plants was progressed by several advancements in analytical instrumentation, from its discovery to elucidation of its signaling pathway. There is currently limited understanding of ethylene’s role in mammals, but evidence suggests that it may be a biomarker for oxidative stress! Additional tools and technology are crucial to study this surprising and important signaling role in mammals. Our group has developed molecular ethylene probes as a strategy to detect ethylene …

Humanizing Computational Literature Analysis Through Art-Based Visualizations, Alexandria Leto

Electronic Theses and Dissertations

Inequalities in gender representation and characterization in fictional works are issues that have long been discussed by social scientists. This work addresses these inequalities with two interrelated components. First, it contributes a sentiment and word frequency analysis task focused on gender-specific nouns and pronouns in 15,000 fictional works taken from the online library, Project Gutenberg. This analysis allows for both quantifying and offering further insight on the nature of this disparity in gender representation. Then, the outcomes of the analysis are harnessed to explore novel data visualization formats using computational and studio art techniques. Our results call attention to the …

Identity And Resistance: Queer Puerto Rican Subjects, Pentecostalism, And The Shadow Of U.S. Imperialism, Jared Vázquez

Electronic Theses and Dissertations

James K.A. Smith argues that the first principle of Pentecostalism is that the same Holy Spirit described in the New Testament is !actively, dynamically, and miraculously present both in the ecclesial community and in creation” today. This ontological experience of the Holy Spirit transforms Pentecostalism into a hermeneutic thorough which Pentecostals interpret their social world. In his attempt to articulate a Pentecostal epistemology Smith leaves implied what this project seeks to make explicit: the emergence of subjectivity is mediated through the experiences of the body and is therefore affective and phenomenological in nature. I argue that pentecostal spiritual practices are …

Music Theory Pedagogy For The Violin: Cognitive Philosophy And Three Model Curricula, Morganne J. Mcintyre

Electronic Theses and Dissertations

Violin playing promotes a connection between mind and body that allows the performer to internalize, or embody, tactile features of the instrument, such as the distance between strings, the feeling of the fingertips on the fingerboard, the interval size between notes, and many other aspects. This thesis designs a pedagogy that employs the violin’s physical attributes to provide the beginning through advanced player with a deeper understanding of music theory. The thesis suggests pairing of physical learning and musical theory at each stage of a violinist’s musical education. Chapter 1 surveys embodied cognition and cognitive artifacts. Chapter 2 applies these …

Mis-Specification Of Functional Forms In Growth Mixture Modeling: A Monte Carlo Simulation, Richa Ghevarghese

Electronic Theses and Dissertations

Growth mixture modeling (GMM) is a methodological tool used to represent heterogeneity in longitudinal datasets through the identification of unobserved subgroups following qualitatively and quantitatively distinct trajectories in a population. These growth trajectories or functional forms are informed by the underlying developmental theory, are distinct to each subgroup, and form the core assumptions of the model. Therefore, the accuracy of the assumed functional forms of growth strongly influences substantive research and theories of growth. While there is evidence of mis-specified functional forms of growth in GMM literature, the weight of this violation has been largely overlooked. Current solutions to circumvent …

Developing, Refining, And Testing The Intersectional Model Of Service Use: A Transgender And Nonbinary-Specific Model Of Healthcare Access, Jarrod Call

Electronic Theses and Dissertations

Transgender and nonbinary (TNB) people are more likely to experience negative health outcomes than cisgender (i.e., not TNB) people, but less likely to access healthcare services due to the systemic forces of transphobia and cisgenderism. Despite this, there are few theoretical models of healthcare access specifically designed for TNB people. This three-paper dissertation addresses this gap by developing, refining, and testing the Intersectional Model of Service Use (IMSU), a population-specific framework for researching TNB healthcare access. Manuscript one describes how the initial IMSU was developed from an integrative review of currently available TNB healthcare access literature. This initial IMSU was …

Economic Theology And The Death Of God In The Context Of The Crisis Of Neoliberalism, Jared A. Lacy

Electronic Theses and Dissertations

In light of the ongoing political and economic crises in the twenty-first century, this study aims to apply the discourse of political theology, alongside Nietzsche’s concept of the death of God to an understanding of neoliberalism and the problems it faces on a global level. However, because of the centrality of sovereignty in political theological discourse and the view of neoliberalism as diffusing sovereignty in favor of an ordered system, I attempt to further develop an offshoot discourse of political theology referred to as economic theology. This discourse allows a theological signature of power to be traced through the history …

A Labor Of Love: Extensive Exploitation Of Contract Music Workers, Malia Odekirk

Electronic Theses and Dissertations

Workers across the United States are reckoning with unfair labor conditions by unionizing and speaking out. Systemic undervaluing of many workers has created a climate of fear, hidden agendas, and pervasive labor misconduct. The pageantry/marching arts are no exception. As a cultural insider, I conducted interviews, had many informal conversations, and ran a large survey that uncovered how the marching arts exploit instructors extensively despite their experience, education, and efforts. A systematic proclivity toward late payments, abused contracts, egregiously low compensation, and free labor begs the question: how can programs continually mistreat instructors this way? I explore this question through …

The Genuine Alacrity Of Things, Evelyn Hampton

Electronic Theses and Dissertations

“The Genuine Alacrity of Things” is a short story collection. Themes include personal identity, the Anthropocene, grief, family, and relationships. The story collection is introduced by a critical introduction.

Organellar Zn2+ Homeostasis And The Role Of Trpml Channels In Neuronal Lysosome Physiology And Axonal Transport, Taylor Franklin Minckley

Electronic Theses and Dissertations

Zinc (Zn²⁺) is crucial for proper cellular function, and as such it is important to measure and track Zn²⁺ dynamics in living cells. Fluorescent sensors have been used to estimate Zn²⁺ content of subcellular compartments, but little is known about endolysosomal Zn2+ homeostasis. Similarly, although numerous sensors have been reported, it is unclear whether and how Zn²⁺ can be released from intracellular compartments into the cytosol due to a lack of probes that can detect physiological dynamics of cytosolic Zn²⁺. My dissertation started with comparing and characterizing different Zn²⁺ sensors including the …

Mobility Of Older Adults In Mexico City: A Mixed Methods Approach, Jessica Villena Sanchez

Electronic Theses and Dissertations

This dissertation covers the topic of the mobility of older adults in Mexico City using a mixed methods approach. First, I looked at the literature to uncover what is known about elderly mobilities coming from the Global South. Second, I analyzed the 2017 Household Origin Destination Survey to reveal travel behavior patterns and transport mode choice of older adults in Mexico City. Third, I revealed mobility experiences from older adults living in different neighborhoods in Mexico City by conducting twenty two telephone interviews. Lastly, I created joint displays that included both previous results to better understand how the findings from …

Experiences Of Chinese American Psychology Trainees In Multicultural Education, Helen Weng-Ian Chao

Electronic Theses and Dissertations

Although research has established that students of color have unique experiences in their multicultural training, few studies have examined the experiences and needs of specific subgroups of students of color. This study examined Chinese American psychology trainees’ experiences in multicultural education. Qualitative data was collected from individual semi-structured interviews with Chinese American doctoral students (N = 6). Interpretative phenomenological analysis was used to understand participants’ perceptions of their experiences in multicultural courses. Data analysis resulted in four themes: the (1) burden of being minoritized, (2) Chinese American identity inflection points, being (3) sidelined by whiteness, and (4) …

Faculty Facilitation Of Help-Seeking On Campus: A Phenomenological Study, Lillian V. Clark

Electronic Theses and Dissertations

An ever-increasing number of students on college campuses are experiencing distress, and not all students in need of care are being reached (Kitzrow, 2009, LeViness, et al., 2019). Faculty are one of the most valuable resources for identifying and connecting students to care (Kitzrow, 2009). Despite this, we know very little about the experiences of faculty working with students in distress. This study sought to understand those experiences, as well as identify the barriers to connecting students to care. A qualitative study using an Interpretive Phenomenology framework was conducted (Smith & Osborn, 2007, Moustakas, 1994). Four themes were interpreted from …

“I, Too, Am An Occupied Territory”: Border Crossings And Personal Sovereignty In Three Novels By Dominican American Women, Leia M. Lynn

Electronic Theses and Dissertations

Border crossing(s) and personal sovereignty are intimately and complexly connected in novels by and about Dominican American women. Through readings of In the Name of Salomé by Julia Alvarez, Dominicana by Angie Cruz, and The Poet X by Elizabeth Acevedo, I argue that patriarchal forms of authority remove female autonomy by trespassing on personal boundaries, and that the renegotiation of that power is achieved through formations of community, especially with other women, through nonheteronormative relationships that are present inside and extend outside the text. The interplay of patriarchal authority, violence, and alienation on the four protagonists is examined at length, …

Regardless, ‘I’ And ‘You’: Lessons From Black Feminist Literature, Jasmine Veronica Sauceda

Electronic Theses and Dissertations

This thesis analyzes Toni Morrison’s Beloved, Octavia E. Butler’s Parable of the Sower, and Alice Walker’s The Color Purple from a Black feminist perspective to demonstrate oneness as capacious being. This project explores an I-You dialogue that works toward future-making through the notion of regardless, an idea from Walker’s definition of Womanist, deployed through sustained engagement with Kevin Quashie’s notion of oneness. Thus, this work extrapolates lessons found in the selected texts to demonstrate what it means to embody a capaciousness of being and how this then fosters healing in the face of trauma. In so doing, …

Development And Testing Of Remote Facilitation Of Prevent-Teach-Reinforce For Families To Address Challenging Behavior In Young Children (Ptr-F:R), Abby Hodges

Electronic Theses and Dissertations

As children advance through developmental stages, they often present behavioral difficulties such as tantrums, lack of cooperation, and aggression. For some children, behaviors are serious enough that they interfere with the child’s ability to engage in positive relationships, participate in necessary routines, and learn new skills, warranting behavioral intervention (Dunlap et al., 2017). Being responsive to the needs of the family and appreciation for the central role that they play is crucial to the success of behavioral interventions and the maintenance of positive outcomes (Bailey, 2013; Campbell, 1995), thus, their input should be at the center of all recommendations and …

Application Of An Organizational Evaluation Capacity Assessment In A Multinational Ngo: A Case Study To Support Applied Practice, Ryan James Smyth

Electronic Theses and Dissertations

As evaluation capacity building (ECB) has rapidly emerged as a practice in human service organizations and as a field of academic inquiry, attention has focused on methods of evaluation capacity building while assessment of organizational evaluation capacity (EC) has lagged behind. To examine the practice of organizational evaluation capacity assessment, this dissertation presents two separate but related studies. In sub-study 1, I present a qualitative evidence synthesis of the research theorizing organizational evaluation capacity models. In sub-study 2, I support the implementation of one of the tools from the evidence-synthesis at a multinational human service organization. I use a concurrent …

Principals’ Perspectives Of Trust And Vulnerability In Leadership: A Grounded Theory Study, Megan Ostedgaard

Electronic Theses and Dissertations

Leadership is a challenging task and leading well requires interpersonal skills that inspire those they lead to follow them. The aim of this grounded theory study is to explore the experiences of educational leaders who thoughtfully engage in trust-building and express vulnerability in their leadership practices. This study explored how six principals at kindergarten through 12th grade schools experience trust and vulnerability as building leaders. Three research questions guided this study: how do leaders experience trust, how do leaders generate trust, and how do leaders experience vulnerability.

In this study, we begin by understanding the background to the problem and …

Investigating Spatiotemporal Kinetics, Dynamics, And Mechanism Of Exosome Release, Anarkali Mahmood

Electronic Theses and Dissertations

Exosomes are small lipid-based vesicles that can carry biomolecules from one cell to another. While exosomes are crucial to maintain homeostasis in healthy cells, they are exploited by unhealthy cells to aid disease progression. Exosomes likely facilitate disease progression via the transfer of disease-causing biomolecules from unhealthy to healthy cells. Exosomes are generated in Multivesicular endosomes (MVEs) and are then secreted into the extracellular space to travel to other cells. Despite being a crucial step, very little is known about exosomes release mechanism and dynamics. To further our understanding of exosomes, specifically their secretion, my work has focused on investigating …

Memorable Messages Received By Bereaved Parents: Using Attribution Theory To Understand Hurt And Compassion, April Samaras

Electronic Theses and Dissertations

The communication bereaved parents have with family members, friends, colleagues, and healthcare providers following the death of a child can serve as a great comfort or exacerbate their grief. In order to understand this communication and why bereaved parents find it helpful or harmful, this study examines bereaved parents' experiences of compassionate and hurtful communication using the frameworks of memorable messages (Stohl & Reardon, 1981) and attribution theory (Jones & Davis, 1965; Kelley, 1967). Fifty bereaved parents who lost a child between birth and 25-years-old completed an online survey. Tracy’s (2018) iterative analysis method revealed four types of compassionate messages: …

Phosphatidylserine Externalization On Non-Apoptotic Cells And Lipid Scramblases In C. Elegans, Julia Frondoni

Electronic Theses and Dissertations

Cell corpse clearance is key for animals to avoid inflammation and autoimmune disease. To better understand the “eat me” signal of phosphatidylserine (PS) exposure for non-apoptotic corpse clearance, we attempted to disrupt the externalization of PS on C. elegans polar bodies. The second polar body undergoes a non-apoptotic form of cell death, loses membrane integrity, externalizes PS and is cleared by embryonic cells during early development. During apoptotic and necrotic cell death, PS asymmetry is disrupted by lipid scramblases, which translocate phospholipids between the leaflets of the lipid bilayer. We found neither apoptotic nor necrotic scramblases are required for PS …

Development And Initial Validation Of An Acculturation Measure For Arab Expatriates In Qatar Using Mixed Methods, Sara Ali Ahmed Zikri

Electronic Theses and Dissertations

Prior research on acculturation has predominantly focused on specific immigrant and ethnic groups in the United States, Europe, and Asia, and there is a lack of publicly available scales that measure acculturation among expatriates in countries of the Gulf Cooperation Council. The purpose of this study was to use a mixed methods research design to develop a theoretical framework of acculturation for white-collar Arab expatriates in Qatar as well as a culturally appropriate self-report acculturation measure. The acculturation stories and experiences of white-collar Arab expatriates in Qatar were qualitatively explored and analyzed, and their findings were used to construct an …

"How It Was Made", Bethany Fitts

Electronic Theses and Dissertations

This is a meta-autoethnography describing the researcher’s unfocused, rhizomatic research process throughout the COVID19 pandemic. Themes explored are the COVID19 pandemic, family, death, climate change, queer love, represenation, academia, genre, and religion. The study shows how multiple scales of grief arise during the research process. I locate this method within postcolonial theory of autoethnography that seeks to diversify structures within the academic genre.

Serially Concatenated Continuous Phase Modulation With Sova Turbo Decoding, Zhijie Guo

Electronic Theses and Dissertations

For a Serially Concatenated Continuous Phase Modulation (SCCPM) system that concatenates a rate of 1/2 Convolutional Code (CC) and an M-ary full response continuous phase modulation (CPM) signal, we design a turbo decoding scheme using the Soft Output Viterbi algorithm (SOVA) and study the system performance. A decomposition model is used in CPM to reduce the number of states and separate the continuous phase encoder (CPE) with the modulator. As a soft-input soft-output (SISO) decoding algorithm, SOVA is used to generate and update the soft information of decoded signal symbols during the iterative process for both the CPM signal and …

Clean. Freaks., Christopher Jackson Morris

Electronic Theses and Dissertations

An excerpt from an experimental literary crime novel interrogating adolescent identity, internalized anti-queerness, mental illness, and white moderatism.

Examining The Effect Of The Florida Talented Twenty Program On Black Acceptance Rates At Flagship Institutions In Alabama, Juwan D. Robinson

Electronic Theses and Dissertations

Americans are more college-educated today than at any point in history. Black Americans have experienced persistent inequities in higher education, especially in southern states. Alabama’s history of inequity, segregation, and lack of signature initiative to generate college access maintain and sustain gaps in higher education for Black Alabamians. Black students are especially underrepresented at the two flagship institutions in the state of Alabama. In a complex legal and political context, race-conscious efforts are often challenging to advance. This positions race-neutral efforts such as percentage plans as more viable in states such as Alabama. This study examines the application of the …

Emotional Carry-Over In Ethical Decision Making: The Impact Of Self-Control And Moral Potentcy, Franklin Faison Tillman

Electronic Theses and Dissertations

Recent theories have posited that emotions play a central role in ethical decision making. However, most research has focused on and suggested that consumers follow cognitive, rational processes in decision making. While this is a well-established approach, research regarding the role of emotions in ethical decision making has gained considerable theoretical attention in recent years. Although various factors have been investigated for the influence on ethical judgments, the role of task related, and incidental emotions have received less attention. Theoretical models that examine ethical decision-making conflict at times and are historically divided into either a rational-based approach or a non-rationalist-based …

Exploring The Standard Model And Beyond Using B And D Meson Decays, John Waite

Electronic Theses and Dissertations

In this research, I have tested the standard model(SM) and various new physics (NP) models using B and D meson decays. In D meson decays, the SU(3) flavor symmetry of the SM for Cabibbo favored decays is tested against experimental measurements. The SU(3) analysis with η and η′ are considered in a general and consistent way for the first time. In B decays, a fit to the data for four B → πK decays is performed, within the SM and with NP. The fit confirms that the SM gives a poor fit to the B → πK data which is …