Digital Commons Network^™

Formulation Design And Development For Extended-Release Drug Delivery System, Sheng Feng

Electronic Theses and Dissertations

The drug delivery system enables the release of the active pharmaceutical ingredient to achieve a desired therapeutic response. Conventional, non-controlled drug delivery systems are unable to deliver the drug at a sustained rate which leads to poor bioavailability, fluctuations in plasma drug concentration, and potential side effects. The extended drug delivery system enables drug delivery at a sustained or predetermined rate to achieve maximum efficacy and safety. Different routes of drug administration, along with various extended-release dosage forms have been extensively developed such as oral delivery, parenteral delivery, transdermal delivery, ocular delivery, and tumor delivery among others. This dissertation developed …

Efficient Design Of Neural Network Hardware Accelerator For Enhanced Performance In Deep Learning Systems, Tamador Nadem Mohaidat

Electronic Theses and Dissertations

Artificial intelligence (AI) hardware accelerator is an emerging research for several applications and domains. The hardware accelerator aims to provide high computational speed while retaining low cost and high learning performance. The main challenge is to design complex machine learning models on hardware with high performance. In this thesis, the aim is to develop the hardware implementation of perceptron within a neural network. Innovative hardware-based approaches are explored to optimize perceptron networks, enhancing accuracy, reliability, and fault tolerance while minimizing resource requirements and power consumption.

A thorough investigation into machine learning accelerators and associated challenges was initially conducted. The hardware …

Heterologous Expression, Isolation, And Metabolomic Profiling Of Myxobacteria To Explore Their Potential In Natural Product Biosynthesis, Nawal Mohamed Hamed Elsayed Shehata

Electronic Theses and Dissertations

Myxobacteria are distinguished by their ability to produce a spectrum of natural products,positioning them as an active resource for therapeutic discovery. These products include metabolites with significant antibacterial, antifungal, cytotoxic, antiviral, and immunosuppressive properties. Current synthetic biology tools for the exploration of myxobacteria are not as advanced as those for the well-studied Streptomyces. This thesis presents an evolution of synthetic biology techniques specifically designed for the exploitation of myxobacteria in the realm of natural product discovery. Chapter One investigates the potential of myxobacteria to act as heterologous hosts due to their large genomes and their capacity for diverse biosynthetic processes. …

An Argument Against Positivist Separability, Nichalus Zoltan Vali

Electronic Theses and Dissertations

One of the most influential views associated with legal positivism is that of the separability thesis. Primarily associated with H.L.A Hart, this thesis is widely understood to be the view that there is no necessary connection between law and morality. However, John Gardner takes this to be a naïve interpretation of separability that fails to adequately characterize legal positivism and which Hart himself did not endorse. Instead, Hart and other legal positivists were committed to the view that whether a norm is legally valid depends on its sources (i.e., social facts such as official engagement with the norm) and not …

Atomistic Simulation Of Pfas And Graphene: Interactions For Water Applications, Bashar Moufeed Awawdeh

Electronic Theses and Dissertations

The contamination of drinking water by per- and polyfluorinated alkyl substances (PFAS) is a global issue. PFAS have been widely utilized in a variety of applications, including water and stain-resistant coatings, fire suppression foams, cosmetics, paints, and adhesives. They have been detected in soils and rivers globally due to their widespread use and resistance to degradation. The strong C–F bonds of PFAS make them exceedingly stable and hard to remove. In order to remediate PFAS contamination in the environment, it is essential to develop selective adsorbent materials that can effectively capture a wide range of PFAS structures. On April 10, …

Cationic Charge-Shifting Polymers As Improved Vectors For Nucleic Acid Delivery, Alexander Fortenberry

Electronic Theses and Dissertations

This work investigates the development and application of charge-shifting polycations for gene delivery, focusing on their synthesis, characterization, and applications for in vitro mRNA delivery. Utilizing poly(2-vinyl-4,4-dimethylazlactone) (PVDMA), this study explores modifications with various reactive handles, such as alcohol, thiol, and amine groups, to create cationic amide-, ester-, and thioester-functionalized polycations. These modifications aim to exploit the charge-shifting capabilities of the polycations to form stable polyplexes with nucleic acids, promoting the efficient intracellular release of the genetic cargo.Initial studies first examine the charge-shifting properties of PVDMA-based polycations under different pH and temperature conditions. This work highlights the potential of these …

Ecological And Evolutionary Ramifications Of Host-Parasite Interaction In Aquatic And Model Ecosystems, Akacia Halliday-Isaac

Electronic Theses and Dissertations

Host-parasite interactions are ubiquitous and have negative risks and consequences on individual, population, and evolutionary scales. These risks and consequences include altered population densities, changes in interspecies interactions, and rapid changes in host phenotypes. In this thesis, I seek to understand the ecological and evolutionary ramifications of host-parasite interactions within ecosystems. To do this, I investigated the presence and environmental correlates of potential host-parasite interactions in a freshwater ecosystem and used a model ecosystem to explore how past host-parasite coevolution affects community assembly dynamics and future adaptation in the presence of new stressors. To examine the presence of potentially parasitic …

Acoustic Localization In Reverberant Environment, Xing Yang

Electronic Theses and Dissertations

The main goal of this dissertation is to develop algorithms to accurately locate and detect underwater oil leakages through sounds emitted by oil-induced bubbles recorded by passive hydrophones. These algorithms aim to create an early warning system to prevent or identify catastrophic oil spills from pipelines, wellheads, and seafloor seepage.

Effects Of Off-Season Fall-Winter Farm Field Flooding On Nitrogen Gas Production, Andrew Rosson

Electronic Theses and Dissertations

Increased nitrogen (N) fertilizer use and cultivation of N-fixing crops have dramatically increased agricultural N inputs to the global N cycle. Excess N on agricultural lands is highly susceptible to loss through runoff or atmospheric emissions, potentially as a greenhouse gas (GHG). Nitrous oxide (N2O), a GHG with a warming potential ~300 times that of carbon dioxide (CO2), primarily enters the atmosphere through denitrification, which converts bioavailable nitrate (NO3-) to inert nitrogen gas (N2), with N2O as an intermediate. Wetlands are crucial for de-nitrification and N regulation due to their wet, anoxic soils, but have declined worldwide, including substantial losses …

Exploring African American Female Students' Choice Of Stem Major At Rust College, Shatara Hall

Electronic Theses and Dissertations

In comparison to the rest of the United States population, African American women are undeniably inadequately represented in the fields of science, technology, engineering, and mathematics (STEM). As one of the oldest historically black colleges in Mississippi, Rust College has the social responsibility to increase the presence and contributions of minorities in STEM. Since the enrollment of African American females is greater than that of African American males at Rust College, the college has the fortuity to assist in increasing the diversity in STEM for both race and gender. This DIP utilizes Intersectionality Theory as the conceptual foundation to explore …

Il-17a Inhibitors For The Treatment Of Psoriasis, Mangesh Bankhele

Electronic Theses and Dissertations

Psoriasis is a long-lasting skin condition caused by the immune system, which is characterized by red, scaly areas. It mainly affects the scalp, elbows, knees, and lower back. Psoriasis, which affects around 2-3% of the world's population, has a substantial influence on the quality of life of people who suffer from it. The disorder arises due to an atypical immunological response in which the immune system mistakenly attacks skin cells, causing fast cell reproduction, inflammation, and excessive growth. Psoriasis can be treated with topical therapies, systemic drugs, and biologics. Topical therapies, including corticosteroids, vitamin D analogs, and retinoids, are commonly …

Formulation And Characterization Of Clotrimazole Buccal Films Using Hot Melt Extrusion, Harish Kandhuri

Electronic Theses and Dissertations

Clotrimazole is a broad-spectrum antifungal /antimycotic, it is used topically in the treatment of oropharyngeal candidiasis. The oral route is the most preferred route of administration 60% of the conventional dosage forms are available as tablets and capsules. The main objective of the study was to develop and Formulate Clotrimazole oral film to get local effect for treating oropharyngeal candidiasis. Oral films are thin flexible strips which can be placed on the tongue, where it adheres to the surface of the tongue and dissolves releasing the drug into the oral cavity. Here, the films are formulated using hot melt extrusion …

Grace Satellite Spatial Resolution Downscaling Using Machine Learning: Methods And Applications, Abdel Rahman M. Awawdeh

Electronic Theses and Dissertations

The Gravity Recovery and Climate Experiment (GRACE) satellite mission has been instrumental in advancing our understanding of global water dynamics, providing unprecedented insights into terrestrial water storage (TWS). Despite its revolutionary contributions, the coarse spatial resolution of GRACE data (~300 km² grids) limits its utility for local-scale water resource management, particularly in regions requiring detailed hydrological analysis such as the Mississippi Delta. This dissertation addresses this limitation by developing and validating machine learning models to enhance the spatial resolution of GRACE data, thereby facilitating more precise and effective local water management strategies.

This research first establishes a comprehensive background in …

Increasing Minority Student Enrollment: An Applied Research Study On Increasing The Enrollment Of Minority Students In Advanced Placement Courses, Tamekia Helm

Electronic Theses and Dissertations

Addressing the disparity in Advanced Placement (AP) course enrollment among minority students at Greater High School is the focus of this research. Through an extensive review of the literature, the study examines the various factors contributing to this gap, including access limitations and systemic barriers. Additionally, teacher perceptions, student attitudes, and parental involvement are explored to understand the influence on AP course enrollment decisions. Utilizing a mixed-methods approach, including surveys and interviews, data is collected from students, teachers and parents to gain comprehensive insights.

Proposed solutions to enhance AP course enrollment include targeted outreach initiatives and support for minority students. …

Indirect And Direct Pathways Of Migratory Shorebird Effects On Nitrogen Cycling Within Temporarily Flooded Agricultural Fields, Victoria Blocker

Electronic Theses and Dissertations

The global human population continues to grow exponentially, and agriculture will need to become more productive to meet growing food demands. Humans also need clean water and other services that ecosystems provide. This requires future agriculture production to reduce environmental and wildlife impacts through improved efficiencies and best management practices. Migratory shorebirds rely on wetlands throughout North and South America as stopover habitat for rest and refueling during migration. Temporarily flooded farmlands in the Mississippi Delta have proven to be beneficial locations for shorebirds during migrations along the central flyway. This conservation practice also enhances wetland properties that promote excess …

Longevity In Afrikaner Cattle: A Survival Analysis, Allison M. Bot Steffl

Electronic Theses and Dissertations

The Afrikaner breed of cattle is indigenous to South Africa and due to their hardiness was once the most popular breed amongst farmers. The objectives for this study were to: (1) estimate environmental effects (age at first calving, season) and (2) genetic variance affecting longevity in Afrikaner cattle using survival analysis and a Weibull model and (3) evaluate the effect of the Infusion Project on longevity utilizing a Cox model. For the first objective, age at first calving impacted longevity as younger age at first calving was associated with decreased longevity. Season of birth and year of birth also impacted …

Understanding Angler Responses To Fish Stocking Programs Across South Dakota, Riley L. Mounsdon

Electronic Theses and Dissertations

Fisheries management is a complex process that often requires consideration of many factors to be implemented effectively. Stocking is one of the most often used fisheries management techniques for addressing a myriad of issues in the fisheries field. Stocking is also one of the largest expenses for many fisheries management agencies. Due to license sale declines, management actions including stocking, are being evaluated by many agencies to determine if there are ways to improve efficiency and effectiveness to reduce costs and enhance angler participation. For my second chapter, I evaluated the current fish stocking decision-making process within South Dakota Game, …

Influence Of Reduced Salt In Fully Cooked Ham And Sausage Cured With Natural Celery Powder On The Growth Of Listeria Monocytogenes At 4⁰C, Anne Sherod

Electronic Theses and Dissertations

This research evaluated the influence of reducing salt on outgrowth of L. monocytogenes on ready to eat (RTE) deli-style sliced ham cured with natural celery powder, fully cooked sausage links cured with traditional sodium nitrite and sausage links cured with natural celery powder, vacuum packaged and stored at 4⁰C on the outgrowth of L. monocytogenes. Experiment 1 evaluated L. monocytogenes outgrowth on ham over 153 days on the following treatments, current retail ham (HC) 2.0% salt; reduced salt 1 (HRS1) 1.5% salt; reduced salt 2 (HSR2) 1.35% salt; and reduced salt 2 without antimicrobials (HRS2WA) 1.35% salt without potassium lactate …

Scaffold Hopping For The Lead Optimization Of The Orally Active Antileishmanial Pyrrolo-Quinazoline Alkaloid Natural Product Peganine, Sunitha Jada

Electronic Theses and Dissertations

Leishmaniasis is a protozoan parasitic disease caused by the species Leishmania that affects millions of people around the world. It is a serious public health concern in the developing world with about 1 million cases and 70,000 fatalities occurring each year. It has several forms with visceral, and cutaneous leishmaniasis being the most common forms of the disease. Visceral leishmaniasis, caused by the Leishmania donovani occurs mainly in Brazil, Eastern Africa, and India, and is fatal if left untreated. The current treatments for leishmaniasis such as pentavalent antimonials, amphotericin B, miltefosine, paromomycin, pentamidine, and some azoles suffer from serious drawbacks. …

Various Surfactant Soil Conditioner Effect On Plant Nutrient Concentration, Soil Nutrient Depletion, Soil Volumetric Water Content, Plant Biomass And Yield In Corn, Timothy Veldkamp

Electronic Theses and Dissertations

Soil conditioners help improve soil structure by increasing aeration, water infiltration and water holding capacity leading to nutrient availability and reduced irrigation needs. The goal of this study was to evaluate the impact of multiple soil conditioners (SC1, SC2, SC3, SC4, and SC5) on corn (Zea mays L.) and their ability to reduce irrigation by 30%. This was evaluated in the field in 2022 and 2023 by Aurora, SD using a Randomized Complete Block Design with six replications. Conditioners were applied as broadcast pre-emergence treatments with 70% irrigation. Control treatments of 70% and 100% irrigation, respectively were included. SC1 application …

Impact Of Varying Molecular Weights Of Hyaluronic Acid On The Functional Properties Of Process Cheese Product, Rutvi Joshi

Electronic Theses and Dissertations

Hyaluronic acid (HA) is being accepted for use as a food ingredient and/or food supplement. It is available in a wide range of molecular weights (MW) and represents unique moisture retention properties depending on the MW. The moisture retention property of HA would be of great economic potential for the dairy industry. HA is a natural polysaccharide and holds the potential as a functional ingredient in dairy and food applications to modify viscosity and textural properties. The first research objective of the study was to determine the impact of very low to high MW of HA - 8kDa, 320kDa, 980kDa, …

Role Of Production Systems On Carcass And Palatability Attributes Of Bison, Lydia Margaret Hite O'Sullivan

Electronic Theses and Dissertations

The overall objective of this dissertation was to determine the impact of finishing systems on carcass and palatability attributes of bison. The specific objectives were 1) determine the influence of finishing system (grain-finished vs. grass-finished) on the mechanisms of tenderness formation in the longissimus lumborum of bison bulls, 2) determine the influence of diverse finishing systems on carcass characteristics and proximate composition of bison heifers, and 3) determine the influence of diverse finishing systems on palatability of striploin steaks from bison heifers. Results indicate that finishing systems differentially influence carcass characteristics, tenderness, and flavor attributes of bison. Specifically, this is …

The Relationship Between Soil Test Phosphorus And Soil Biology - A Natural Management Of Soil Phosphorus Through Conservation Practices, Clarence Frederick Winter

Electronic Theses and Dissertations

Phosphorus (P) management is an ongoing challenge in modern agriculture. Due to the importance of P in agriculture, P fertilizer additions are made throughout the U.S. to avoid nutrient-depleted soil. However, the application of P is problematic, as an excess of P in an agricultural system elevates the risk of environmental degradation, and current synthetic P sources are a fleeting resource. Additionally, a majority of P found in agricultural soils are insoluble, in the form of secondary and primary P minerals, making this large pool of P unavailable to plants. Fortunately, soil fungi organisms, such as arbuscular mycorrhizal fungi (AMF) …

Optimizing Large Language Models And Multimodal Approaches For Biomedical Publication And Satellite Imagery, Youngsun Jang

Electronic Theses and Dissertations

This dissertation comprises two main sections: the first focuses on natural language processing (NLP) for extracting key information from scientific literature using large language models (LLMs), and the second addresses remote sensing for detecting natural disasters, such as floods, from satellite imagery using a multimodal approach. The first section investigates methods to enhance Transformer-based models in classifying and extracting information from biomedical scientific publications. Key contributions include the development of a custom dataset for classification and Question and Answering (Q&A) tasks, fine-tuning Transformer models like the Bidirectional Encoder Representations from Transformers (BERT) and addressing multi-span answer issues with the TAg-based …

Genetic And Ecologic Effects Of Seed Dormancy Genes On Seed Aging, Soil Seedbank Longevity, And Microbiome In An Isogenic Background Of Rice ( Oryza Sativa L.), Bhupinder Singh Batth

Electronic Theses and Dissertations

No abstract provided.

Whole Genome Crispr-Cas9 Screens Identify Genes Contributing To Viral Entry And Phagocytosis, Md Saddam Hossain

Electronic Theses and Dissertations

CRISPR/Cas9 is a revolutionary technique for genome editing where Cas9 nucleases can be targeted to specific genomic sites by single-guide RNAs (sgRNAs) containing roughly 20-nucleotide sequences that are complementary to the target region. Double strand breaks created by Cas9 are repaired through non-homologous end-joining (NHEJ) in most cells, resulting in insertions and deletions leading to frame shift mutations in coding regions. Thus, the CRISPR-Cas9 system can be exploited for systematic evaluation of gene function relationships by whole genome screening. We also developed a CRISPR whole‐genome screen and counter‐screen strategy based on a pseudoviral platform that allowed identification of genes specific …

Impacts Of Starter Fertilizer On Corn Development, Nutrient Uptake And Grain Yield In Eastern South Dakota, Larousse Dorissant

Electronic Theses and Dissertations

Cold and wet spring conditions during planting in the Northern Corn Belt can limit nutrient mobility, especially phosphorus (P) due to reduced mineralization. This often triggers the use of starter fertilizers to enhance nutrient availability within the root zone, and as a result improve nutrient uptake and the overall plant growth. Albeit research has shown that starter fertilizer applications can significantly boost corn grain yield potential, the most substantial yield responses from starter fertilization are typically observed in fields where soil test P levels fall below the critical soil test P threshold. This dissertation explores i) the effects of starter …

Analysis Of Toxic Chemical Agents And Therapeutics For Toxic Inhaled Agents’ Exposure, Khadija Bilkis

Electronic Theses and Dissertations

When inhaled, toxic inhalation agents (TIAs) such as cyanide (CN), ammonia and sulfur compounds (e.g. methanethiol (MeSH)) can be fatal. Many TIAs cause cellular hypoxia, cytotoxic anoxia, apnea, respiratory failure, neurodegenerative disorder, circulatory collapse, seizures, and potential death by blocking mitochondrial cytochrome c oxidase. All TIA’s have the potential to be employed as chemical warfare agents, terrorist weapons, or dangerous occupational gases. Although many TIAs are potential threats, there are minimal FDA-approved treatments for these substances useful in a mass-casualty situation. Recently, cobinamide (Cbi) has come to light as a potential antidote for MeSH poisoning. However, methods for analyzing MeSH …

Perceived Linguistic And Non-Linguistic Barriers Facing Saudi Female Partners Learning English, Samah Mohamad Dulli

Electronic Theses and Dissertations

The partners of the Saudi students who come to the United States on scholarships to earn a degree (Bachelor's, Master's, or Ph.D.) are eligible for full scholarships as well. However, most of them fail to proceed in earning a degree or fulfill the language proficiency requirement needed to join an academic degree program. This study surveys between 10 to 20 adult female partners of Saudi university students to elicit their opinions on how much English they think they will learn during their partner scholarship time in academic and non-academic settings. This study investigates the female partners of the Saudi degree …

Punishing Poverty: An Examination Of Financial Disadvantage And Out-Of-School Suspension, Joshua Rosenbaum

Electronic Theses and Dissertations

School suspension is often a response by officials to address deviant behavior within the school setting. While studies have examined various causes and consequences of school suspension, there is a dearth of literature focusing on the effects of financial disadvantage on school discipline (i.e., school suspension). Given that out-of-school suspension is a reliable predictor of juvenile justice involvement later in life, it serves as an important outcome variable in preventative criminology. Using data from the National Longitudinal Study of Adolescent to Adult Health (Add Health), the purpose of the current study is to analyze the relationship between financial disadvantage and …