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Using Self-Assessment Tools And Complementary Alternative Therapy For Chronic Migraines In Menopausal Women, Krystal Rachelle Bridwell

Electronic Theses and Dissertations

Abstract

Migraine headaches are ranked as one of the highest disabling conditions in the United States. Women who are in the perimenopausal transition phase have a higher prevalence of disabling migraines that can result in a decreased quality of life, loss of income, decreased productivity, and a higher risk for emotional difficulties. The gap in practice is the lack of education on complementary alternative medicine (CAM) and the use of a migraine diary to recognize individual symptoms as a substitute or cotherapy with pharmacologic treatments. The purpose of this scholarly project was to improve clinical practice and outcomes for perimenopausal …

The Multipurpose Dna Repair/Redox Protein Ape1 In Rodent And Human Lewy Body Disease, Kristin Marie Miner

Electronic Theses and Dissertations

Lewy body disorders are a family of neurodegenerative conditions characterized by proteostatic and redox disequilibrium, leading to deposition of the abundant protein α-synuclein in hallmark inclusions and oxidative damage to DNA. Sublethal oxidative DNA damage in neurons is repaired predominantly by the base excision repair pathway, which involves the coordinated activity of several enzymes, including apurinic/apyrimidinic endonuclease 1 (APE1). Despite emerging connections between α-synuclein, oxidative stress, and DNA damage/repair, along with evidence demonstrating the multifunctional nature of APE1, the link between APE1 and α-synuclein has not yet been explored.

Here, we conducted a broad investigation of APE1 in the context …

Design, Synthesis, And Biological Evaluation Of Novel Heterocyclic Compounds For The Treatment Of Cancer And Neurodegenerative Disorders, Saloni Patel

Electronic Theses and Dissertations

Alzheimer's disease (AD) is a progressive neurodegenerative disease that impairs memory and cognitive judgment, mostly in older people. It is the leading cause of dementia in late adult life. The hallmarks of AD include neuronal loss, neuroinflammation, a build-up of extracellular amyloid beta (Aβ) plaques, intracellular neurofibrillary tangles, and extracellular neuritic plaques. Current treatment, although useful, is not adequate. Identification of therapeutic agents with the potential to alter the progress of AD is a high priority. Recent studies suggest that the Sigma-2 receptor is an attractive target for the development of disease-modifying AD drugs. Preventing the binding of Sigma-2 receptors …

The Effect Of Novel Microtubule Modulators On Experimental Lewy Body Disease, Anuj S. Jamenis

Electronic Theses and Dissertations

In Lewy body disorders, α-synuclein aggregates are believed to destabilize the microtubular framework. However, microtubules are a challenging therapeutic target, as excessive rigidity or flexibility afforded by microtubule modulators may be neurotoxic. Thus, the objective of the present study was to evaluate dual-acting microtubule- stabilizing/destabilizing agents in cellular and animal models of early-stage Lewy body disease.

In Aim 1 we tested the dual-acting tricylic pyrimido[4,5-b]indole analogs AG161-47 and AG161-41 in an in vitro preformed fibril induced model of Lewy body disease. We found that both compounds reduced preformed fibril-seeded α-synucleinopathy without toxicity in primary hippocampal cultures. AG161-47 subtly impacted microtubule …

Stimuli-Responsive Glycopolymeric Nanoparticles To Boost Tumor Immunogenicity Through Macrophage-Targeted Therapy, Oluwaseyi Shofolawe-Bakare

Electronic Theses and Dissertations

Tumor-associated macrophages (TAMs) play a substantial role in sculpting the tumor microenvironment (TME) into an immunosuppressive bastion that undermines immune surveillance and enables tumor progression. They therefore represent a promising therapeutic target to make the TME more conducive for anti-tumor immunity and greatly improve treatment outcomes in cancers that are highly resistant to conventional forms of therapy. Several medications have been developed to modulate the activities of TAMs, showing tremendous potential, but these medications lack specificity for TAMs making their use susceptible to adverse side effects that could outweigh prospective benefits. Sophisticated delivery vehicles that can preferentially deliver these medications …

Assessing The Psychological Benefits Of Biophilic Design In Therapeutic Counseling Spaces, Andrew Graf

Electronic Theses and Dissertations

This dissertation explores the intersection of biophilia and counseling, aiming to illustrate the potential benefits of integrating nature-based interventions into therapeutic practice. Biophilia, the innate human tendency to connect with nature, has garnered attention in various fields, yet its implications for counselors remain unexplored. This qualitative study employs a hermeneutic phenomenological approach to investigate the lived experiences of counselors who have incorporated biophilic elements into their practice and the perceptions of clients who have engaged with these interventions.

Through semi-structured interviews with licensed counselors, themes emerged regarding the impact and use of biophilic interventions on the therapeutic process. Findings suggest …

School Nurses And Administrators Perceptions Of School Preparedness: A Focused Ethnography, Deborah Horton

Electronic Theses and Dissertations

Background: Disasters are dangerous for schools where many children are located in one area. Children were significantly impacted by a biological incident during the 2009 H1N1 influenza pandemic, and more recently the COVID-19 pandemic. Research is needed to determine the values, perceptions, and beliefs of school disaster preparedness through a cultural lens.

Methods: A focused ethnography was used to interview school administrators and nurses from April-December 2022 to explore and understand the unique culture of school disaster preparedness. Data was analyzed according to Leininger’s Four Phases of Data Analysis.

Results: Twenty-four participants from K-12 public schools were interviewed resulting in …

Exploring The Mandelbrot Set, James Shirley

Electronic Theses and Dissertations

The Mandelbrot set is a mathematical mystery. Finding its home somewhere be-
tween holomorphic dynamics and complex analysis, the Mandelbrot set showcases
its usefulness in fields across the many realms of math—ranging from physics to nu-
merical methods and even biology. While typically defined in terms of its bounded
sequences, this thesis intends to illuminate the Mandelbrot set as a type of param-
eterization of connectivity itself, specifically that of complex-valued rational maps
of the form z → z² + c. This fully illustrated guide to the Mandelbrot set merges
the worlds of intuition and theory with a series of …

Omani Camels From A Cultural And Genomics Perspective, Al Muatasim Al Zadjali

Electronic Theses and Dissertations

The Dromedarian camel, Camelus dromedarius, is native to the Arabian Peninsula, including the Sultanate of Oman. These camels are used for food, milk, as well as show and racing competitions. Despite their economic and cultural importance research on camels in Oman is limited. The goal of this study was to examine their genomic variation, relationship with camels in other parts of the Arabian Peninsula, and to determine if selective breeding has led to the establishment of distinct breeds in Oman. Information was compiled from multiple sources to produce a comprehensive review on the breeding, management, economic and cultural use, …

Within-Day Reliability Of Submaximal Running Economy Testing: Implications For Advanced Footwear Testing, Garrett Oehlert

Electronic Theses and Dissertations

Running economy (RE) has been identified as a critical component of endurance performance. Alterations in footwear have shown to significantly impact RE. Quantifying reliability of within-day RE measures may determine differences that could be expected when testing footwear. PURPOSE: Assess within-day reliability of RE testing on a calibrated metabolic system. METHODS: Trained male distance runners (n=10) were recruited to perform 4 × 5-minute trials (set speed, in habitual running shoes) at their estimated marathon pace (5-minute rest period) during a single visit to the lab. Oxygen consumption (VO2) data were collected during the final two minutes of each stage and …

Circumcision—Deal With It! A Clinical Ethnography Of Intactivism At American Intersections, Benjamin M. Gaddes

Electronic Theses and Dissertations

On a routine trip to the grocery store, or while scrolling online, you might encounter the provocative and puzzling discourse of Intactivism, a viral, single-issue social movement that opposes infant male circumcision, and wonder “Huh? Why is this here, now?” This project situates Intactivism in a history of circumcision and anti-circumcision that spans from ancient Sumerian tents to the front pages of Reddit. It takes an immersive qualitative clinical ethnographic approach, nested in a broader cultural psychology that is non-reductive and pluralistic, to articulate an Intactivist ethos in its public and private dimensions. Methods include participant-observation, interviews, and framework discourse …

Evaluation Of Changes In Evaporative Losses From Lake Powell Reservoir Contributions In The Colorado River Basin, Maria Mlinarcik

Electronic Theses and Dissertations

The Colorado River Basin (CRB) is one of the most critical water sources for the western United States (U.S.) and Mexico. For over a century, numerous policies and regulations have been implemented in attempts to manage the Colorado River Basin to address the concern of overuse, collectively referred to as the “Law of the River.” The USGS hydrologist E.C. LaRue warned that the optimistic estimates used in negotiating the Colorado River Compact did not align with the actual water availability in the river. His analysis in 1925 revealed a potential deficit if all allocated water was utilized, exacerbated by overallocation …

Surface Water Quality Assessment Of Mingo Creek County Park: The Impacts Of Extractive Industries, Mikayla J. Bayto

Electronic Theses and Dissertations

Historical and current extraction operations and infrastructure, including natural gas pipelines, conventional and unconventional oil and natural gas drilling, longwall coal mining, and strip coal mining, occur throughout the Mingo Creek watershed of Washington County, Pennsylvania, including Mingo Creek County Park. Mingo Creek and several associated tributaries flow through Mingo Creek County Park, eventually discharging into the Monongahela River. An independent water quality study was conducted from June 2020 through July 2023 in Mingo Creek County Park to determine if historical and current extraction activities impact Mingo Creek and its associated tributaries. Weekly sampling of Mingo Creek and associated tributaries …

The Distinctive Contribution Of The Catholic Tradition On Emerging Ethical Issues Around Embryos., Michael Donkor

Electronic Theses and Dissertations

This dissertation considered the distinctive contribution of the Catholic Church surrounding emerging ethical issues around embryos. In many Catholic doctrines, the church has stated that the embryo must be treated as if it were a human person with (soul) and must be protected. The embryo is considered an individual with relational qualities worthy of all the rights given all humans per the natural law.

The Church continues to oppose all forms of assisted reproduction that eliminates the unitive and procreative nature of marriage as it violates the dignity of the child and marriage. Technologies such as lower tubal ovum transfer(LTOT), …

Impact Of Glycerophosphocholine Metabolism On Phenotypes In Saccharomyces Cerevisiae And Schizosaccharomyces Pombe, Victoria Hrach

Electronic Theses and Dissertations

Glycerophosphocholine (GPC) is an abundant metabolite in eukaryotes. In baker’s yeast, Saccharomyces cerevisiae, GPC can be produced via deacylation of the major membrane glycerophospholipid phosphatidylcholine (PC). My lab has identified a novel pathway to re-synthesize PC from GPC by acylating it at the sn-1 and sn-2 positions; this pathway has been termed the PC Deacylation-Reacylation Pathway (PC-DRP). We previously characterized the acyltransferase Gpc1 and its ability to synthesize one-tailed lyso-PC from GPC, as well as that noting that GPC1 is upregulated in inositol-free conditions and results in more saturated PC. Here, I add to this basic characterization by establishing …

Characterization Of A Novel Metalloid Reductase Outer Membrane Porin Rara From Sulfurospirillum Barnesii Ses-3, Narthana Jeganathar Kanmanii

Electronic Theses and Dissertations

Sulfurospirillum barnesii SES-3 is a gram-negative epsilon proteobacterium that grows anaerobically by coupling the oxidation of lactate to the reduction of arsenate. Previous work on metal and metalloid metabolism in S. barnesii had identified a redox active protein, designated RarA that when provided an artificial electron donor (i.e., reduced methyl viologen, FMN, or NADH), could reduce a variety of substrates, including arsenate, selenate, selenite, nitrite, and even phosphate. The enzyme’s inferred amino acid sequence showed weak similarity (30%) to outer membrane porins with homologs found in only certain species of Sulfurospirillum. Further, the enzyme did not contain cysteine residues …

Comparative Functional And Computational Analyses Of Primate Seminal Proteins: Insights Into Sexual Selection And Hiv/Siv, Emine Feride Kahveci

Electronic Theses and Dissertations

Male reproductive protein-coding genes are among the most rapidly evolving genes across many animal taxa, commonly attributed to sexual selection; however, pathogen defense mechanisms might also be contributing factors. This study aimed to both computationally and experimentally investigate the selective pressures responsible for the rapid evolution of seminal proteins. In the first part, the research focused on sexual selection in the form of post-copulatory sperm competition as a driving force behind the evolution of kallikrein related peptidase 3 (KLK3), also known as prostate-specific antigen (PSA), a key prostatic seminal protein. KLK3 is responsible for the liquefaction of semen coagulum through …

Quaternary Diamond-Like Sulfides For Nonlinear Optical Applications: Investigation Into Composition-Structure-Property Relationships Of The I2-Ii-Iv-Vi4 And I4-Ii-Iv2-Vi7 Formulae, Jordan Kelly

Electronic Theses and Dissertations

The research work presented in this dissertation focuses on the synthesis, characterization, and property assessment of new and existing quaternary diamond-like semiconductor (DLS) materials for the potential application in infrared (IR) nonlinear optics (NLO). Chapter 2 discusses the previously discovered temperature-dependent polymorphs of Cu₂ZnGeS₄ (CZGS); however, the IR NLO properties, neutron powder diffraction data, and single crystal X-ray diffraction structures were previously undetermined. The high-temperature α-CZGS polymorph was superior to the low-temperature β-CZGS analog in both second harmonic generation (SHG) and laser-induced damage threshold (LIDT). Chapter 3 presents the discovery of Li₂MgGeS₄ and comparison …

Targeting Cancer- One Carbon At A Time: Design And Synthesis Of Pyrimidine Based Heterocycles As Potential Cancer Chemotherapeutics, Md Junayed Nayeen

Electronic Theses and Dissertations

With over 6 million death counts, cancer is the second leading cause of death in the United States. Lung cancer was the leading cause of cancer death, accounting for 23% (136,084 death count) of all cancer deaths. Other than that, colon and rectal (9%, 51,869 death count), pancreas (8%, 46,774 death count), female breast (7%, 42,275 death count), prostate (5%, 32,707 death count), and liver and intrahepatic bile duct (5%, 28,227 death count). Other cancers individually accounted for less than 5% of cancer deaths. Although cancer death rates decreased about 27% from 2001 to 2020, the therapeutic options are limited …

Development Of A Rapid Bacterial Quantification Method Based On Droplet Microfluidics, Shawn Bliss

Electronic Theses and Dissertations

The capacity to identify bacteria quickly and accurately is critical for applications such as medical diagnosis, environmental monitoring, and food safety. For instance, sepsis diagnosis requires blood cultures that take as long as 1-5 days, preventing timely intervention and increasing mortality rate. Here, we propose the joint use of microfluidics and a machine learning algorithm for rapid bacterial cell capture and quantification. The combination of high-throughput droplet microfluidics and a support vector machine (SVM) enables analysis and quantification of bacterial samples within as short as 4 hours. We have performed successful encapsulation of pathogenic bacteria such as E. coli, …

The Contributions Of Philosophical Anthropology To Healthcare Ethics, Bura Koroba

Electronic Theses and Dissertations

The first principles of bioethics, autonomy, beneficence, nonmaleficence, and justice have contributed immensely to healthcare ethics. The procedural approach streamlines the decision-making process, protects vulnerable subjects, and fosters stability and trust in the patient-caregiver relationship. Yet, the principles are demonstrably insufficient, riddled with limitations and loopholes that could stand in the way of care.[i] Several recommendations have been proffered to remedy the deficiencies. Value ethics, for instance, has been touted as a proficient addendum to the foundations established by the principles. Still, these have not sufficiently addressed all arising issues in bioethics. Besides the challenges encountered in decision-making, opposing …

The Contribution Of Pope Francis’ Integral Ecology To Global Ethics, Salvatore Enzo Del Brocco

Electronic Theses and Dissertations

The defense of the dignity and inviolability of human life has always gained prominence in the doctrine of the Catholic Church. With Pope Francis' concept of integral ecology, Catholic bioethics is expanded to a broader understanding. His vision of integral ecology, global bioethics, and solidarity emphasizes the interconnectedness of all things and the importance of caring for one another and the planet. It calls us to recognize our common humanity and to work together for the common good by facing the numerous emerging problems of our times, which threaten the dignity of human life and the future life of the …

Transforming Chaplain Ethics: The Clinical Ethics Of Spiritual Care In A Pluralistic Healthcare Environment In The United States, Robert Alan Price

Electronic Theses and Dissertations

This dissertation, “Transforming Chaplain Ethics: The Clinical Ethics of Spiritual Care in a Pluralistic Healthcare Environment in the United States,” aims to examine the clinical ethics of religious and spiritual care provided by clinical chaplains for patients and families receiving treatment in a pluralistic healthcare context in the United States.

Clinical chaplains are more than clergypersons and they are more than clinicians; they are a highly specialized marriage of both worlds. There is a fundamental asymmetry between functioning as a leader in a local religious community or faith tradition and providing clinical spiritual care in a pluralistic healthcare environment. This …

A Critique Of The Pivotal Ethical Issues In Organ/Tissue Donation & Transplantation, Francis Sarpong

Electronic Theses and Dissertations

Organ or tissue donation has proven to be a lifesaving intervention for patients battling failing or failed organs or tissues. However, scholars have raised concerns about just and rational procurement and transplantation in a global shortage. This dissertation addresses normative approaches for organ/tissue procurement, allocation and transplantation to highlight the related pivotal ethical issues. It defends normative approaches such as queuing and nudging, and upholds their universal obligatoriness. It provides illumination about the demands of an effective solution to who shall receive or give organs when not all can. The introductory chapter employs common morality as a principal source of …

Dredging The Wetlands, Tilling The Field: Ecotonal Poetics Of The Anthropocene, Stacey Balkun

Electronic Theses and Dissertations

This dissertation interrogates the use of poetic fragmentation as a tool of ecological representation and coins the term “ecotonal poetics.” Ecotonal poesis, this dissertation explains, is the stretching of lyric across the field of the page, using space, sound, language, and parataxis in its attempt to not only represent but create ecotonal ecologies through text, sound, and visual cues. This dissertation puts forth four case studies of contemporary American women poets turning the space of the page into an ecotone where text, white space, author, reader, body, and environment meet. The poets studied here rely heavily on textual experimentation, suggesting …

Structure-Based Design And Semi-Synthesis Of Kratom-Derived Mu-Opioid Receptor Agonists With Varying Intrinsic Efficacy, Emily Wells

Electronic Theses and Dissertations

No abstract provided.

Design And Synthesis Of Novel Mitochondrial Pyruvate Carrier Inhibitors For The Treatment Of Metabolic Disorders, Henry Politte

Electronic Theses and Dissertations

No abstract provided.

Design Of Fxr Agonists For The Treatment Of Non-Alcoholic Steatohepatitis, Amanda Morrison

Electronic Theses and Dissertations

No abstract provided.

Consequences Of Altered Burn Regimes On Plant Community Diversity In The Pineywoods Of East Texas, William Steinley

Electronic Theses and Dissertations

The re-establishment of historic fire return intervals is vital to restoring forest health, species diversity, natural succession regimes, and reduction of some invasive species. Studies on the effect of fire frequencies on southern pine understory plant communities have revealed increased plant diversity and richness in response to fire, particularly in longleaf pine. The National Forests and Grasslands of Texas (NFGT), The Nature Conservancy (TNC), and the privately-owned Winston 8 Ranch are intensively managed using prescribed burns at different frequencies for a variety of management objectives.

In this study we aimed to further investigate the effect of fire frequency, stand characteristics, …

Exploring Peer Perspectives On Autistic Students: A Vignette Study, Justin Linville

Electronic Theses and Dissertations

A 2x2 design was undertaken to determine the effects of vignette character gender and autism disclosure status on social distance scores, reading comprehension performance, and false memory induction. The introduction focuses on the theoretical threads taken from the autism, false memory, and gender literatures and how they combine to create the underpinning of the current design. A second more controlled study was compelled by initial false impressions of the deleterious effects of fast completion times. This second study resulted in lengthened completion times and improved vignette comprehension. Two-way MANOVAs with gender and autism disclosure serving as independent variables on the …