Digital Commons Network^™

The Localized Surface Plasmon Resonance (Lspr) Response Of Gold And Gold/Silver Metal Nanostructures To Protein Binding And Global Refractive Index Changes., Srinivas R. Beeram

Electronic Theses and Dissertations

This dissertation describes new procedures for synthesizing and purifying Au and Au/Ag nanoplates directly on surfaces as well as controlled binding of proteins to their surface. It also describes fundamental changes in the optical properties of Au and Au/Ag nanoplates upon interaction with different liquids, proteins, or nanoparticles. Finally, this dissertation describes the highly selective and sensitive label-free detection of proteins in an immunoassay format using the optical properties of Au and Au/Ag nanostructures. A chemical seed-mediated growth procedure allowed the synthesis of Au nanoplates directly on surfaces with an initial 23% yield. Purification by either sonication or adhesive tape …

Arsenic In Drinking Water Causes Gene Expression Changes In The Liver Related To Inflammation And Metabolic Dysfunction And Accelerates Atherosclerosis In Apoe-/-Mice, Matthew R. Zajack

Electronic Theses and Dissertations

Arsenic exposure in drinking-water is a significant worldwide health problem. It causes adverse human health effects, such as cancer, increases the risks for others such as cardiovascular disease, and accelerates atherosclerosis. In this study, we analyze arsenic-induced gene expression changes in the liver of ApoE-knockout mice given 49 ppm arsenic in drinking-water. We hypothesize chronic arsenic exposure accelerates atherosclerosis by disrupting liver homeostasis, causing aberrant gene expression changes. Networks revealed hubs on 3 stress-response MAP kinase pathways, ERK, JNK, and p38. Pathways revealed mitochondrial dysfunction and oxidative phosphorylation enrichment from the gene set. Transcription factor binding site analysis revealed specific …

Shape-Based Detection Of Cortex Variability For More Accurate Discrimination Between Autistic And Normal Brains., Matthew Joseph Nitzken 1987-

Electronic Theses and Dissertations

Introduction: Autism is a complex developmental disability that typically appears during the first three years of life, and is the result of a neurological disorder that affects the normal functioning of the brain, impacting development in the areas of social interaction and communication skills. According to the Centers for Disease Control and Prevention (CDC) in 2009, about 1 in 110 American children will fall somewhere in the autistic spectrum. Although the cause of autism is still largely not clear, researchers have suggested that genetic, developmental, and environmental factors may be the cause or the predisposing effects towards developing autism. While …

Effect Of Finger Rings On Microbial Cross-Contamination During Dental Clinical Procedures., Swapna Nadikuda

Electronic Theses and Dissertations

CDCIWHO only "recommends" that rings be removed under gloves because of cross-contamination between health care workers and patients. Microbiological samples of oral streptococci beneath rings and between fingers under non-sterile exam gloves were taken before and after dental procedures (before and after washing with antimicrobial soap) from 50 junior/senior dental students. Subjects wore two rings on one hand, with none on the other (control). Rings were worn on the opposite hand at another session. Handedness, glove tears, and leaks, were also measured. There were significant glove tears and leakage in the glove on the dominant hand, especially when wearing rings …

An Examination Of Caregiving Dyads: Community Dwelling Chronically Ill Older Adults And Their Caregivers, Jessica E. Haxton

Electronic Theses and Dissertations

Increases in life expectancy among older adults raise important concerns about the availability of resources for an aging population living with chronic and debilitating illnesses. Living longer is complicated by the fact that many elders prefer to reside in their homes until medical or other conditions require an alternative living arrangement. The strong desire to remain at home expressed by older persons in the United States has in turn created an increased demand on informal caregiving. Consequently, adult children often bear the burden of providing care to their aging parents. In view of this demand it is critical that research …

Greening The Green Revolution: Moving Beyond Chemicals To Sustainable Agricultural Practices, Elizabeth G. Crawley

Electronic Theses and Dissertations

Agriculture has dominated the economy of many developing countries for centuries, which has led to development policies that center on agricultural development. An obvious approach to improved production is to decrease agricultural losses in the fields and increase efficiency to markets. This study focuses on the developmental role of pesticides and chemical fertilizers on non-traditional agricultural export farming and the adoption of IPM techniques. With farmers in the Comayagua Valley of Honduras, an Asian vegetable production center for the country, as the study population, the costs and benefits of planting oriental vegetables was examined. Statistical analysis was used to examine …

Dogs And Technology: Our Most Beloved Companions In Twentieth And Twenty-First Century America, Claire V. Bow

Electronic Theses and Dissertations

Since the suburban rush and steep rise in household technological devices in the mid-twentieth century, Americans have drawn apart from each other, a shift that has coincided with a rise in both dog ownership and the adoption of handheld mobile devices. This paper argues that these phenomena, which are both ubiquitous and intimate in many American households, reflect one of the most basic and static human needs: the need for emotional connection. Furthermore, it is the unique combination of canine and digital elements that replace human-to-human social networks; networks that were once both literally and figuratively tightly drawn. In the …

Unmasking Whiteness: A Framework For Understanding Inclusive Leadership At A Predominately White Institution, Nicole Marie Latino

Electronic Theses and Dissertations

This study explored the personal journey of 11 White college administrators who were identified as inclusive leaders at a predominately White institution (PWI), recognized nationally for its work on partnering diversity and excellence. One overall question guided this study: How do White college administrators describe their journey to becoming successful inclusive leaders at a predominately White institution? This question was explored from the perspective of critical race theory (CRT), that is, inclusive leadership for White administrators could be achieved by intentionally examining their construction of Whiteness and their personal racial identity.

Narrative inquiry was used to co-construct a developmental framework …

Development Of A Men's Depression Inventory, Andrew Fields

Electronic Theses and Dissertations

This paper details the development of a scale to more accurately assess depression in men. It first summarizes the literature on depression, depression assessment, and current research on men and masculinity. It is argued that current conceptualizations of both depression and masculinity influence prevalence studies, which consistently find that men experience depression half as often as women. It is argued that an assessment measure that accounts for masculine variants of depression (substance use, anger, withdrawal, and emotional restriction) may identify more frequent depression in men than previously expected. Next, the paper details the development of a men's depression scale using …

Ethical Elitism: A Burkean Analysis Of The Rhetorical Construction Of A Moral Persona In The First Term Of President George W. Bush, Veronica Lynn Koehn

Electronic Theses and Dissertations

On November 4, 2004, President George W. Bush won re-election. According to exit polls, a majority of people who voted for Bush over his opponent, Senator John Kerry, did so because they believed that Bush was the “moral values” candidate. In this dissertation, I assess the moral persona that the President rhetorically constructed during his first term in office. To do so, I utilize Kenneth Burke‟s cluster and pentad tools to analyze Bush‟s statements on embryonic stem cell research, 9/11 and the ensuing War on Terror, and same-sex marriage, three issues that the elite press explicitly identified as being “moral …

Compulsory Death: A Historiographic Study Of The Eugenics And Euthanasia Movements In Nazi Germany., Michael Creed Hawkins

Electronic Theses and Dissertations

This thesis is a historiographical study of the eugenics and euthanasia programs of Nazi Germany. It traces there development from the end of World War One to the fall of Hitler's Third Reich. There are three stages in this study. First, I examine eugenics after World War One and the effect the era had on society. Then I study the Nazi transition from eugenics measures to "euthanasia", and last I analyze the transferring of the killing methods from the "euthanasia" centers to the concentration camps. The questions of how did the idea for eugenics develop in Germany society, what role …

Inhibition Of Escherichia Coli Atp Synthase By Polyphenols And Their Derivatives., Prasanna Keerthi Dadi

Electronic Theses and Dissertations

We have studied the inhibitory effect of natural and structurally modified polyphenols on Escherichia coli ATP synthase to test (I) if the beneficial dietary effects of polyphenols are related to their inhibitory actions on ATP synthase, (II) if inhibitory effects of polyphenolic compound could be augmented through structural modifications, and (III) if they can act as antimicrobial agent through their actions on ATP synthesis. X-ray crystal structures of polyphenol binding sites suggested that polyphenols bind at a distinct polyphenol binding pocket, at the interface of α,β,γ-subunits. We found that both natural and modified polyphenols inhibit E. coli ATP synthase to …

Assessing Commercial Organic And Conventionally Grown Vegetables By Monitoring Selected Heavy Metals Found In Them., Charles Kafui Dotse

Electronic Theses and Dissertations

Commercially available organic and conventionally grown vegetables were studied by quantitative determination of selected metals in them and to determine if any differences found are statistically significant. These findings can help the consumers to determine if the vegetable products are within the recommended maximum limits as proposed by the joint FAO/WHO Expert committee on organic foods designation. Eight edible vegetables were purchased from local stores in both the organic and conventionally grown categories. Samples were digested with concentrated nitric acid and the metals monitored were zinc, copper, lead, iron, cadmium, and nickel using flame atomic absorption. The concentration range for …

Political Accommodation: The Effects Of Booker T. Washington's Leadership And Legacy On Tuskegee University And The Tuskegee Syphilis Experiment., Dominique Dubois Gilliard

Electronic Theses and Dissertations

In this re-evaluation of the Tuskegee Syphilis Experiment, I identify the original causes that made the Study emerge, examine why the intent of this research shifted over time, reveal the manner in which the Study was conducted, expose the role the government played in the manipulation of the Experiment, and, finally, investigate the ways, as well as the reasons, for the selection of the participants involved in the Study. After exploring the Experiment itself, I investigate the lasting effects of it on the community in which it occurred and the ways in which it further affected the relationship between African …

Critical-Incident Response: A Study Of Training, Management, And Mitigation In North Carolina Sheriffs' Offices., Gregory Alan Minton

Electronic Theses and Dissertations

The purpose of this study was to determine the amount of training each sheriff's office requires in North Carolina and if that training includes multiagency exercises designed to mitigate a critical-incident response and identify any concerns from those training events. The study also compared departmental strength (number of sworn officers per agency) with county populations and geographic area of the state the agency is located in with the number of hours required annually by each agency. Finally, each agency was asked if it had participated in a multiagency exercise and a multiagency incident and to identify any issues that occurred …

Generating Compact Wasp Nest Structures Via Minimal Complexity Algorithms., Fadel Ewusi Kofi Adoe

Electronic Theses and Dissertations

Many models have been developed to explain the process of self organization-the emergence of seemingly purposeful behaviors from groups of entities with limited individual intelligence. However, the underlying behavior that facilitates the emergence of this global pattern is not generally well understood. Our study focuses on different low complexity building algorithms and characterizes how nests are built using these algorithms. Three rules postulated to be functions of wasps' building behavior were developed. First is the random rule, in which there is no constraint per the choice of site to be initiated. The second is the 2-cell rule where only sites …

Isolation And Identification Of The Siderophore "Vicibactin" Produced By Rhizobium Leguminosarum Atcc 14479., William H. Wright Iv

Electronic Theses and Dissertations

Siderophores are small, iron chelating molecules produced by many bacteria to help meet the iron requirements of the cell. Multiple metabolic functions require iron as it serves as a cofactor in many enzymes and cellular processes. However, in the presence of oxygen and at physiologic pH, iron forms insoluble ferric complexes that cause the nutrient to be unavailable to bacterial cells. Siderophores alleviate this limitation by chelating the ferric iron, rendering it soluble and available for uptake. One group of microorganisms known for their ability to produce siderophores is the rhizobia. These bacteria are characterized both by their formation of …

Hermit Thrush (Catharus Guttatus) And Veery (C. Fuscescens) Breeding Habitat Associations In Southern Appalachian High-Elevation Forests., Andrew J. Laughlin

Electronic Theses and Dissertations

The Hermit Thrush is a new breeding bird in the Southern Appalachian high-elevation mountains, having expanded its range southward over the last few decades. Here it is sympatric with the Veery, a congeneric breeding resident. In order to more fully understand why the range expansion took place and to understand more about the local ecology of the newly arrived bird, I measured several habitat variables in 30 Hermit Thrush and 24 Veery territories. Principal Components Analysis and Cluster Analysis brought to light several patterns of habitat preferences for these 2 species. Hermit Thrushes prefer territories with more leaf litter on …

Error Correcting Codes And The Human Genome., Suzanne Mclean Lyle

Electronic Theses and Dissertations

In this work, we study error correcting codes and generalize the concepts with a view toward a novel application in the study of DNA sequences. The author investigates the possibility that an error correcting linear code could be included in the human genome through application and research. The author finds that while it is an accepted hypothesis that it is reasonable that some kind of error correcting code is used in DNA, no one has actually been able to identify one. The author uses the application to illustrate how the subject of coding theory can provide a teaching enrichment activity …

Characteristics Of Nectar Production And Standing Crop In Campsis Radicans (Bignoniaceae)., Andrea Alexis Edge

Electronic Theses and Dissertations

We examined several aspects of nectar production in Campsis radicans to better understand how standing crop is affected and how production affects pollinator visitation. In all experiments, nectar and concentration of flowers were measured and total sugar was calculated. Flowers do not produce additional nectar unless nectar is removed, and it is not resorbed. Volume of standing crop and total sugar fluctuates throughout the day, whereas concentration remains constant. Age and time of day significantly affect regeneration of nectar and sugar. The number of removals did not significantly affect the amount of nectar or sugar regenerated; however, concentration declined significantly …

A Re-Evaluation Of The Pleistocene Hellbender, Cryptobranchus Guildayi, And An Overview Of Cryptobranchus Remains From Appalachian Caves., Keila Elaine Bredehoeft

Electronic Theses and Dissertations

Cryptobranchus guildayi is described as an extinct species of large salamander that is closely related to the hellbender, Cryptobranchus alleganiensis. The validity of this extinct taxon has been questioned, so an expanded osteological sample of modern hellbenders was used for comparative purposes with the C. guildayi fossil material. Based on this analysis, all supposed distinguishing morphological characteristics used to define C. guildayi can be observed in specimens of C. alleganiensis, or are based on misidentifications. Therefore, Cryptobranchus guildayi is considered to be conspecific with C. alleganiensis and taxonomically should be considered a junior synonym of the latter. The …

Comparative Morphometrics Of The Sacral Vertebra In Aneides (Caudata: Plethodontidae)., Lisa Nicole Schaaf

Electronic Theses and Dissertations

The genus Aneides (Caudata: Plethodontidae) is an arboreal salamander with a prehensile tail and a distribution that spans North America. It is hypothesized that adaptations for arboreality will be visible in the osteology of the sacral vertebra either by qualitative analysis or linear and morphometric analysis in comparison with other plethodontid salamanders. This study demonstrates that while qualitative and quantitative analyses are successful at making genus-level distinctions between taxa, identification to lower taxonomic levels remains inconclusive. Linear morphometrics and dorsal Procrustes landmarks were the most successful metrics to identify known taxa. Two unidentified fossil salamander sacral vertebrae from Oregon Caves …

A Predictive Model For Secondary Rna Structure Using Graph Theory And A Neural Network., Denise Renee Koessler

Electronic Theses and Dissertations

In this work we use a graph-theoretic representation of secondary RNA structure found in the database RAG: RNA-As-Graphs. We model the bonding of two RNA secondary structures to form a larger structure with a graph operation called merge. The resulting data from each tree merge operation is summarized and represented by a vector. We use these vectors as input values for a neural network and train the network to recognize a tree as RNA-like or not based on the merge data vector.

The network correctly assigned a high probability of RNA-likeness to trees identified as RNA-like in the RAG database, …

Total Domination Dot Critical And Dot Stable Graphs., Stephanie Anne Marie Mcmahon

Electronic Theses and Dissertations

Two vertices are said to be identifed if they are combined to form one vertex whose neighborhood is the union of their neighborhoods. A graph is total domination dot-critical if identifying any pair of adjacent vertices decreases the total domination number. On the other hand, a graph is total domination dot-stable if identifying any pair of adjacent vertices leaves the total domination number unchanged. Identifying any pair of vertices cannot increase the total domination number. Further we show it can decrease the total domination number by at most two. Among other results, we characterize total domination dot-critical trees with total …

Access To Algebra I, Gateway To Success: The Impact Of Eighth-Grade Algebra I., Emily Jean Skelton Darling

Electronic Theses and Dissertations

An understanding of Algebra I and the role that this foundational course plays as an entry to the college preparatory pathway in secondary education and its influence on mathematical achievement is an integral component for the education of American youth in the global world of science and technology. Achievements in high school curricula are cumulative; each course completed determines which paths will be open to the student and which postsecondary education options will be available. In today's world, these options are necessary for the competitive world market. Algebra I is the prerequisite course for subsequent high school math pathways. Students …

Predictors Of Depression In African American Men And Their Implications For Community And Individual Focused Interventions., Michael A. Robinson

Electronic Theses and Dissertations

Background: In any given year depression affects as many as 121 million people worldwide and 20 percent or 19 million people in the U.S. suffer from at least one episode of depression during their lifetime. In the U.S., depression has a substantial impact on the economy. It is estimated that $17 billion dollars in salary and/or equivalent compensation is lost due to missing work days, caused by major depression. Depression is considered a highly prevalent condition that can lead to significant functional impairments, such as absenteeism and work productivity and problems with activities of daily living. This study focuses on …

Comparison Of Clinically Projected And Radiographically Optimal Implant Fixture Placement., William Shane Vaughn 1984-

Electronic Theses and Dissertations

Potential dental implant site assessment is initially determined clinically. Subsequent radiographic assessment also provides information about the quantity of available bone. It was hypothesized that the use of radiographic markers in mandibular stents to project the clinically derived placement of implant fixtures would not correspond to the optimal trajectory of the fixture based on acceptable implant placement criteria applied on Cone Beam Computed Tomography images. A retrospective audit of patients with edentulous mandibles scanned with a surgical guide was completed. A total of 218 potential implant sites in 77 patients were evaluated utilizing an implant planning software package (EZ Guide …

3d Cbct Analysis Of Cranial Base Morphology And Its Relationship To Skeletal Malocclusion., Russell M. Weaver 1973-

Electronic Theses and Dissertations

Determining the etiology of skeletal malocclusion is an important diagnostic step in treatment planning patients with maxillofacial anomalies. Aims: To describe cranial base morphology using cone beam computed tomography (CBCT) images and correlate with the Antero-posterior (AP) jaw discrepancy. Methods: With IRB approval, retrospective analysis was performed on CBCT scans for 40 adult subjects. Cranial flexure and cranial deflection angle were analyzed in relation to three AP variables using linear regression analysis. Results: There were no significant correlations between the cranial base and AP variables. This study can neither confirm that there is a correlation between the cranial base morphology …

Reduced Hyperbf Networks : Practical Optimization, Regularization, And Applications In Bioinformatics., Rami Nezar Mahdi 1982-

Electronic Theses and Dissertations

A hyper basis function network (HyperBF) is a generalized radial basis function network (RBF) where the activation function is a radial function of a weighted distance. The local weighting of the distance accounts for the variation in local scaling and discriminative power along each feature. Such generalization makes HyperBF networks capable of interpolating decision functions with high accuracy. However, such complexity makes HyperBF networks susceptible to overfitting. Moreover, training a HyperBF network demands weights, centers and local scaling factors to be optimized simultaneously. In the case of a relatively large dataset with a large network structure, such optimization becomes computationally …

Generalized Multi-Stream Hidden Markov Models., Oualid Missaoui

Electronic Theses and Dissertations

For complex classification systems, data is usually gathered from multiple sources of information that have varying degree of reliability. In fact, assuming that the different sources have the same relevance in describing all the data might lead to an erroneous behavior. The classification error accumulates and can be more severe for temporal data where each sample is represented by a sequence of observations. Thus, there is compelling evidence that learning algorithms should include a relevance weight for each source of information (stream) as a parameter that needs to be learned. In this dissertation, we assumed that the multi-stream temporal data …