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Acute Synaptic Activity Causes Differential Mirna Expression In The Drosophila Melanogaster Larval Central Nervous System, Robert Ian Sand

Electronic Theses and Dissertations

The primary goal of this thesis was to determine if spaced synaptic stimulation induced the differential expression of microRNAs (miRNAs) in the Drosophila melanogaster central nervous system (CNS). Prior to attaining this goal, we needed to identify and validate a spaced stimulation paradigm that could induce the formation of new synaptic growth at a model synapse, the larval neuromuscular junction (NMJ). Both Channelrhodopsin- and high potassium-based stimulation paradigms adapted from (Ataman, et al. 2008) were tested. Once validation of these paradigms was complete, we sought to characterize the miRNA expression profile of the larval CNS by miRNA array. Following attainment …

Colorado's Large Snow Events' Impact On Tree Ring Growth And Dillon Reservoir, Katrina Leona Marzetta

Electronic Theses and Dissertations

Meteorological observations from 1894 through 2010 suggest that 17 historically large snow events occurred in the mountains of Colorado within Denver's water supply region. Of these 16 events, 14 can be identified in precipitation sensitive tree ring records as positive climatic pointer years. If these storms were to occur today, they would have the potential to fill reservoirs in Denver Water's supply system, even after years of sustained drought. These "drought busters" have the potential to refill Dillon Reservoir by increasing average yearly inflow up to 146% of the previous year's inflow. Such drought busters can help Denver recover from …

Hybrid Sensing And Adaptive Control For Direct Brain Actuation Of Artificial Limbs, Christopher Aasted

Electronic Theses and Dissertations

Developing a non-invasive direct brain control of artificial limbs is both challenging and desirable. Such a sensory and control system, if successful, will have a profound impact on the disabled. In this dissertation, we present the design and development of a non-invasive, hybrid sensory system, which uses near-infrared spectroscopy (NIRS) and electroencephalography (EEG) to measure brain activity with simultaneous electromyography (EMG) to provide feedback data in a healthy limb. Through the combination of these sensory techniques, we have successfully trained a control system capable of mapping brain activity onto muscle actuation. The design of a control algorithm capable of automatic …

Altered Calcium Handling In Cerebellar Purkinje Neurons With The Malignant Hyperthermia Mutation, Ryr1-Y522s/+, George C. Talbott

Electronic Theses and Dissertations

To investigate the etiology of malignant hyperthermia and central core disease, mouse models have recently been generated and characterized (Chelu et al., 2006). These RyRY522S/+ knock-in mutant mice provide an excellent tool to investigate calcium dysregulation, its pathological consequences, and potential therapeutic approaches. Skeletal muscle harboring this mutation exhibits calcium leak from internal stores and an increased sensitivity to activation by caffeine, voltage, and temperature (Durham et al., 2008). Although alterations in RyR1 channel function and resultant changes in cellular function have been characterized in skeletal muscle, the effects of MH mutations in RyR1 on central nervous system function have …

Taking A Deep Breadth: The Rhetorical Construction Of Solidarity In The American Labor Movement, William O'Shannon Murphy

Electronic Theses and Dissertations

This dissertation explores the rhetorical fragments in three case studies of the American Labor Movement constituting movement members in solidarity. Using Kenneth Burke's discussion of rhetorical substance, this project explores the possibilities for developing deep and broad forms of solidarity within the American Labor Movement. Rhetorical fragments of the Industrial Workers of the World, the United Farm Workers, and contingent faculty unionization efforts are explored.

I argue Burke's ideas of substance and identification provide a powerful lens through which we can examine the solidary practices of social movements. Through the examination of the case studies mentioned, I demonstrate that solidarity …

Who's Doing The Dirty Work? Development And Preliminary Validation Of A Measure Of Housework, Jocelyn Nicole Petrella

Electronic Theses and Dissertations

The present study developed a new instrument for measuring couples' attitudes and behaviors regarding housework. This study was conducted in two phases. The first phase focused on developing reliable subscales that would reflect various dimensions of housework. Phase one consisted of 199 individual participants in committed relationships who were working at least 20 hours per week and shared a single home address with their partner. Participants answered questions related to housework through an online survey. An exploratory factors analysis (EFA) revealed eight dominant factors from the housework questionnaire, labeled as: 1) Fairness, 2) Value of Housework, 3) Gender Role Attitudes, …

An Ecological Analysis Of Social And Economic Influences On Black And White Infant Mortality Risk In Orange County, Fl, Littleton, Vanessa Lopez

Electronic Theses and Dissertations

Black health disparities are a salient public health issue with blacks in every socioeconomic level at a greater health disadvantage than their white counterparts. In particular, disparity in infant mortality rates between blacks and whites have widened in recent decades to differentials never before experienced in the United States. Social ecologists investigating the myriad of individual and environmental risk factors have failed to fully account for the persistent differential. This study examines the relationships between individual and environmental influences on the health risk experienced by blacks, whites, as well as the differential between the two populations. This multi-level analysis was …

Harmony Oriented Architecture, Kyle A. Martin

Electronic Theses and Dissertations

This thesis presents Harmony Oriented Architecture: a novel architectural paradigm that applies the principles of Harmony Oriented Programming to the architecture of scalable and evolvable distributed systems. It is motivated by research on Ultra Large Scale systems that has revealed inherent limitations in human ability to design large-scale software systems that can only be overcome through radical alternatives to traditional object-oriented software engineering practice that simplifies the construction of highly scalable and evolvable system. HOP eschews encapsulation and information hiding, the core principles of objectoriented design, in favor of exposure and information sharing through a spatial abstraction. This helps to …

Density Functional Theory Study Of Molecules And Crystals Containing D And F Metals, Shruba Gangopadhyay

Electronic Theses and Dissertations

Density Functional Theory (DFT) method is applied to study the crystal structure of transition metal and lanthanide oxides, as well as molecular magnetic complexes. DFT is a widely popular computational approach because it recasts a many-body problem of interacting electrons into an equivalent problem of non-interacting electrons, greatly reducing computational cost. We show that for certain structural properties like phase stability, lattice parameter and oxygen migration energetics pure DFT can give good agreement with experiments. But moving to more sensitive properties like spin state energetic certain modifications of standard DFT are needed. First we investigated mixed ionic-electronic conducting perovskite type …

Adaptive Responses Of Branchial Morphology To Hypoxia In The Neotropical Electric Fish Genus Brachyhypopomus, Leilani B. Pathak

Electronic Theses and Dissertations

Many tropical aquatic environments worldwide are characterized by intermittent or prolonged hypoxia (low dissolved oxygen). Nevertheless, many tropical freshwater fishes are able to inhabit these challenging environments via a range of morphological, physiological and behavioral adaptations. Brachyhypopomus is a diverse genus of weakly electric fishes represented by 28 known species distributed from Panama to Argentina. 17 species are restricted to permanently normoxic habitats (blackwater rivers and terra firme streams), eight species are restricted to seasonally or perennially hypoxic habitats (whitewater floodplains of large tropical rivers or permanent swampy habitats), and three species are eurytopic (occur in both seasonally hypoxic and …

Assessing Common Variance In Psychopathy Measures, Rochelle Taormina

Electronic Theses and Dissertations

Youth who demonstrate callous and unemotional traits along with aggressive antisocial behaviors are more likely than youth who do not display callous and unemotional traits to continue those acts into adulthood. Similarly there is support in the literature that the psychopathy construct measured in adulthood are evidenced in youth. For example, psychopathy traits measured by the Psychopathy Check List-Revised (PCL-R), noted as the gold standard assessment measure of psychopathy in adults, has been slightly modified for use with youth (i.e., Psychopathy Checklist - Youth Version [PCL-Y V]). The PCL-YV has been identified as a useful predictor of aggressive behaviors among …

The Application Of Melatonin And Platelet-Rich Plasma In The Development Of A Bioactive Calcium Aluminate Bone Regenerative Scaffold, William Clafshenkel

Electronic Theses and Dissertations

Over 500,000 bone graft procedures are conducted annually within the United States. Autografts contribute to donor site complications and disease transmission with allografts has been described. Many ceramics are only osteoconductive and are brittle, limiting their clinical use. Thus, the objective of this study was to create a bone substitute with osteoinductive properties similar to natural bone using the ceramic biomaterial calcium aluminate (CA). Calcium aluminate materials are durable and remain moldable for an extended period of time at room temperature. Further, the surfaces of CA scaffolds can be modified with biological agents through simple chemical means to locally deliver …

A Phenomenology Of Occupation-Based Hand Therapy, Donna Colaianni

Electronic Theses and Dissertations

The founding philosophies of occupational therapy and the medical model have been in conflict within the practice of occupational therapy for more than 60 years. This conflict is especially evident in the hand therapy arena due to the prevalence of the medical model. There is extensive literature outside this specialty area indicating that an occupation-based approach is beneficial for patients with whom it is used yet there is a lack of research on occupation-based hand therapy. Clearly describing and defining what constitutes occupation-based hand therapy can help promote occupation-based practice in keeping with the philosophy of the profession and facilitate …

The Domestic Church And The Post-Nuclear Family: A Theological Analysis And Critique, Corey Harris

Electronic Theses and Dissertations

This dissertation is an attempt to reconcile the Roman Catholic theological understanding that the Christian family is a domestic church (ecclesia domestica) with a realistic demographic and sociological portrait of the American family while remaining faithful to Catholic moral teaching. The first chapter analyzes several works of the Magisterium from the time of Vatican II that have specifically referenced the domestic church. These documents collectively show that the domestic church is a sacramental and ecclesial reality although the theology is commonly espoused under the subheading of marriage and referencing a specifically nuclear form of family. The following chapter analyzes the …

Biopharmaceutic And Pharmacokinetic Evaluation Of Hesperidin And Hesperetin For Ocular Delivery, Ramesh Srirangam

Electronic Theses and Dissertations

The bioflavonoid hesperidin and its aglycone hesperetin are promising candidates for the treatment of diabetic retinopathy and diabetic macular edema because of their pharmacological properties. The objective of this project was to characterize the biopharmaceutic and pharmacokinetic characteristics of hesperidin and hesperetin for ocular delivery, especially with respect to the distribution of these compounds to the posterior segment of the eye. Hesperidin and hesperetin were found to be water insoluble compounds. Although they demonstrated good permeability across the ocular tissues, hesperetin's permeability was found to be higher than that of hesperidin. Hesperidin demonstrated symmetrical transcorneal and transretinal permeation whereas hesperetin …

Zaftig: A Magazine Prototype And Accompanying Business Plan, Alexandra Wagner Pence

Electronic Theses and Dissertations

Currently, there is no voice or home for plus-sized women within the mainstream media. The media industry reflects and promotes an increasingly thin ideal, one that multiple studies have concluded is causing negatiVe self-perception and low self-esteem among young women nationwide. This is especially true for the full-figured woman, whom society tells that she is not skinny enough, and therefore not good enough. This thesis project sets out to prove the host of social benefits that could and would be offered as a result of the instatement of a mainstream women's interest magazine geared specifically towards young plus-sized women. To …

Virtualization And Self-Organization For Utility Computing, Mehdi Saleh

Electronic Theses and Dissertations

We present an alternative paradigm for utility computing when the delivery of service is subject to binding contracts; the solution we propose is based on resource virtualization and a selfmanagement scheme. A virtual cloud aggregates set virtual machines to work in concert for the tasks specified by the service agreement. A first step for the establishment of a virtual cloud is to create a scale-free overlay network through a biased random walk; scale-free networks enjoy a set of remarkable properties such as: robustness against random failures, favorable scaling, and resilience to congestion, small diameter, and average path length. Constrains such …

The Performance And Power Impact Of Using Multiple Dram Address Mapping Schemes In Multicore Processors, Rami Jadaa

Electronic Theses and Dissertations

Lowest-level cache misses are satisfied by the main memory through a specific address mapping scheme that is hard-coded in the memory controller. A dynamic address mapping scheme technique is investigated to provide higher performance and lower power consumption, and a method to throttle memory to meet a specific power budget. Several experiments are conducted on single and multithreaded synthetic memory traces -to study extreme cases- and validate the usability of the proposed dynamic mapping scheme over the fixed one. Results show that applications’ performance varies according to the mapping scheme used, and a dynamic mapping scheme achieves up to 2x …

Mechanisms Of Alpha]-Synuclein-Induced Neurodegenertaion In Parkinson's Disease And Stroke, Cherine Belal

Electronic Theses and Dissertations

Parkinson’s disease (PD) is a debilitating neurodegenerative disorder affecting one million Americans. Despite its social and economic impact, the pathological cascades that lead to neuron dysfunction and degeneration in PD are poorly understood. Endoplasmic reticulum (ER) stress has been implicated as an initiator or contributing factor in neurodegenerative diseases including PD. The ER is an organelle central to protein folding and intracellular Ca2+ homeostasis. Perturbations of these functions result in ER stress and upregulation of ER stress proteins, of which some have been implicated in counteracting ER stress-induced cell death. The mechanisms that lead to ER stress and how ER …

Identification Of Fabrics Likely To Collect And Disperse Fel D 1, Mary Janice Jones

Electronic Theses and Dissertations

Individuals sensitive to domestic cat allergen Fel d 1 experience a variety of symptoms including eye irritation, respiratory irritation, asthma, and severe respiratory distress. Fel d 1 is a protein produced in the saliva and on the skin of domestic cats. Previous studies have demonstrated that Fel d 1 adheres to clothing, upholstery, and human hair and has been found in non-cat environments in levels high enough to cause allergic reactions in sensitive individuals. In a general sense, two very different approaches have been adopted to study Fel d 1. One area of the literature focuses on the molecular biology …

Photodisruption In Ocular Tissue Near And At The Boundary Between The Anterior Chamber And Crystalline Lens, Richard Ty Olmstead

Electronic Theses and Dissertations

Lasers have been involved in Ophthalmology in the treatment of myopia and hyperopia for several years. Laser systems have transformed patients‟ quality of life, freeing them from the need for glasses, as in the case of LASIK. Ultrafast lasers have played an important role in surgery of the eye. In LASIK, they are used to cut the flap that is lifted to expose the stroma for UV Excimer laser treatment of this region. They are now being used for surgery deeper into the eye,for instance, treating the lens as part of treatments for cataract surgery. The use of ultrafast lasers …

Communication Apprehension Vs. Social Phobia And Related Conditions A Correlational Study, Christine M. Donaldson

Electronic Theses and Dissertations

Of all social situations, public speaking is the most prevalent fear in both the general population and among social phobic individuals (Mannuzza, Schneier, Chapman, & Liebowitz, 1995; Stein, Walker, & Forde, 1996). The fear of public speaking is referred to as communication apprehension (CA) by members of the communication field; in other programs of study, this condition has been categorized and conceptualized in a wide variety of ways ranging from stage fright to reticence. Several scholarly fields including communication, social psychology, the health sciences and the social sciences, seek to find an explanation and effective intervention for this prevalent condition. …

Factors Related To Birth Transition Success Of Late-Preterm Infants, Karen L. Wright

Electronic Theses and Dissertations

Problem: Identifying the factors effecting birth transition success of late preterm infants may improve early recognition of newborn compromise. Multiple explanatory variables may be associated with birth transition success or failure. The purpose of the study was to determine the prevalence of, and clinical-epidemiological and demographic predictive factors for birth transition success of late preterm infants. Methods: A retrospective case-control chart review was used to compare the characteristics of successful and unsuccessful birth transition of 35 and 36 week gestational age late-preterm infants delivered in a large tertiary-care center during calendar year 2007. A mixture of categorical and numeric variables …

Multiagent Learning Through Indirect Encoding, David B. D'Ambrosio

Electronic Theses and Dissertations

Designing a system of multiple, heterogeneous agents that cooperate to achieve a common goal is a difficult task, but it is also a common real-world problem. Multiagent learning addresses this problem by training the team to cooperate through a learning algorithm. However, most traditional approaches treat multiagent learning as a combination of multiple single-agent learning problems. This perspective leads to many inefficiencies in learning such as the problem of reinvention, whereby fundamental skills and policies that all agents should possess must be rediscovered independently for each team member. For example, in soccer, all the players know how to pass and …

Use Of Vegetative Mulch As Daily And Intermediate Landfill Cover, Assal Edwar Haddad

Electronic Theses and Dissertations

Management of yard waste is a significant challenge in the US, where in 2008 13.2% of the 250 million tons of municipal solid waste (MSW) was reported to be yard waste. This study describes research conducted in the laboratory and field to examine the application of vegetative mulch as daily and intermediate landfill cover. Mulch was found to exhibit stronger physical properties than soil, leading to a more stable landfill slope. Compaction of mulch was found to be significantly greater than soil, potentially resulting in airspace recovery. Degradation of mulch produced a soil-like material; degradation resulted in lower physical strength …

Neuroendocrine Mechanisms Mediating Pheromonal Modulation Of Behavior In Terrestrial Salamanders, Corina Wack

Electronic Theses and Dissertations

Pheromones are chemosensory cues released by an individual to cause a behavioral or physiological change in a conspecific. These changes can range from increasing a female's receptivity to altering hormone secretions in the body. The red-legged salamander (Plethodon shermani) is an emerging non-mammalian model for understanding the evolution of chemical communication due to their well-characterized pheromones. Plethodontid salamanders secrete pheromones from their submandibular gland, called mental gland pheromones. Previous studies showed that mental gland pheromones increased receptivity in females during courtship and also increased corticosterone (CORT) concentrations in males. CORT is a metabolic hormone that mediates vertebrate stress responses. To …

A Model To Integrate Sustainability Into The User-Centered Design Process, Adrienne Shevonne Brown

Electronic Theses and Dissertations

With concerns for the environment becoming more prevalent in business and the government, it is increasingly important to re-evaluate and update processes to include sustainability considerations early in the design process. In response to this charge, this research effort was designed to integrate sustainability factors into the usercentered design process. The results of this research highlight the benefits of sustainability requirement planning, as well as those derived from integrating sustainability into the current user-centered design model

Spectrum Sharing And Service Pricing In Dynamic Spectrum Access Networks, Swastik Kumar Brahma

Electronic Theses and Dissertations

Traditionally, radio spectrum has been statically allocated to wireless service providers (WSPs). Regulators, like FCC, give wireless service providers exclusive long term licenses for using specific range of frequencies in particular geographic areas. Moreover, restrictions are imposed on the technologies to be used and the services to be provided. The lack of flexibility in static spectrum allocation constrains the ability to make use of new technologies and the ability to redeploy the spectrum to higher valued uses, thereby resulting in inefficient spectrum utilization [23, 38, 42, 62, 67]. These limitations have motivated a paradigm shift from static spectrum allocation towards …

Landfill Gas To Energy Incentives And Benefits, Hamid R. Amini

Electronic Theses and Dissertations

Municipal solid waste (MSW) management strategies typically include a combination of three approaches, recycling, combustion, and landfill disposal. In the US approximately 54% of the generated MSW was landfilled in 2008, mainly because of its simplicity and cost-effectiveness. However, landfills remain a major concern due to potential landfill gas (LFG) emissions, generated from the chemical and biological processes occurring in the disposed waste. The main components of LFG are methane (50-60%) and carbon dioxide (40-50%). Although LFG poses a threat to the environment, if managed properly it is a valuable energy resource due to the methane content. Currently there are …

Stress Shielding Minimized In Femoral Hip Implants A Finite Element Model Optimized By Virtual Compatibility, Christian E. Feldt

Electronic Theses and Dissertations

Bone mechanics and traditional implant materials produce a recurring problem for patients of total hip arthroplasty (THA): the bone is “shielded” from the loading it has become accustomed to over many years of development. Bone adheres to what is called “Wolff’s Law”, meaning it is an adaptive structure which adjusts its geometry based on the loads experienced over its life (Pearson; Goldstein). As the new femoral hip implant transmits reduced stresses to the remaining bone, bone tissue atrophies at the interface, permitting loosening of the implant, pain, and thereby obliging additional surgery to correct the issue (Meade). In the present …