Open Access. Powered by Scholars. Published by Universities.®

Digital Commons Network™

Open Access. Powered by Scholars. Published by Universities.®

Electronic Theses and Dissertations

Discipline
Institution
Keyword
Publication Year

Articles 6511 - 6540 of 10930

Full-Text Articles in Entire DC Network

The Effects Of Intracerebroventricular Leptin On Milk Availability In Lactating Rats, Brittany Lynita Moore Dec 2012

The Effects Of Intracerebroventricular Leptin On Milk Availability In Lactating Rats, Brittany Lynita Moore

Electronic Theses and Dissertations

Reports have linked energy balance along with adipocyte derived leptin action to improved fertility. Recent evidence indicates that leptin hormone is present in breast milk and leptin receptors are well expressed in mammary epithelial cells. The hypothesis that insufficiency of leptin restraint in the hypothalamus may underlie infertility in rodents and the failure of lactating breast to express adequate amount of milk was tested. Female Sprague-Dawley rats were injected leptin through intracerebroventricular cannulation (ICVC) of the third ventricle. Female rats were mated with stud males and observed throughout gestation. Compared to the control groups, leptin treatment increased prolactin levels in …

Go to article

Distribution And Social Structure Of An Estuarine Bottlenose Dolphin (Tursiops Truncatus) Population In Northern South Carolina, Jamie L. Brusa Dec 2012

Distribution And Social Structure Of An Estuarine Bottlenose Dolphin (Tursiops Truncatus) Population In Northern South Carolina, Jamie L. Brusa

Electronic Theses and Dissertations

Information regarding habitat preference of apex predators may pinpoint areas dense in resources such as prey species. Knowledge of how animals use their habitat can enable the classification and targeted management of important habitat features. This study was conducted to determine the distribution and social structure of an inshore population of bottlenose dolphins within the North Inlet-Winyah Bay estuary in northern South Carolina. Photo-identification surveys were conducted along defined transect routes. Home ranges of individual dolphins were calculated using the minimum convex polygon method and the fixed kernel density method using Geographic Information System (GIS) software. Mean group sizes and …

Go to article

Assessment Of Land Use And Neotropical Herpetofauna Along Steep Gradients Of Elevation In An Ecuadorian Ramsar Wetland Site #1143, Nicholas K. Henke Dec 2012

Assessment Of Land Use And Neotropical Herpetofauna Along Steep Gradients Of Elevation In An Ecuadorian Ramsar Wetland Site #1143, Nicholas K. Henke

Electronic Theses and Dissertations

Using a comparative ecological approach, over the course of 18 days at the transition from a particularly wet to dry season in 2010, I assessed herpetofaunal assemblages and related abiotic parameters (i.e., photosynthetically active radiation, specific conductance, temperature and coarse woody debris) between contiguous forest and human impacted areas along three paired transects across the steep elevation gradient at Laguna de Cube, Ramsar site # 1143. Visual encounter surveys were used to capture herpetofauna with species being processed (e.g., weight, digit length, photographed) and identified to the lowest taxonomic level possible. After evaluating transect data for pooling (i.e., no significant …

Go to article

Winter Site Fidelity In Secretive Marsh Sparrows Along The Coast Of South Carolina, Susan M. Shaw Dec 2012

Winter Site Fidelity In Secretive Marsh Sparrows Along The Coast Of South Carolina, Susan M. Shaw

Electronic Theses and Dissertations

Salt marshes, which are threatened by sea level rise and development, provide habitat for a distinctive suite of specialized vertebrates, and knowledge of the life histories of salt marsh specialists may help preserve salt marsh fauna in the face of change. I studied wintering site fidelity of Seaside (Ammodramus maritimus), Saltmarsh (A. caudacutus) and Nelson's (A. nelsoni) Sparrows by mist-netting and banding birds at six sites in two salt marshes in South Carolina. I banded 261 sparrows over two winters, 2009-2010 and 2010-2011, and recaptured 92. Across-year return rates were high, but significantly different across species: 43% for Seaside, 63% …

Go to article

A Tangle Net Study On Relative Abundance And Habitat Preference Of Elasmobranchs In North Inlet Estuary, South Carolina, Moriah Heather Moore Dec 2012

A Tangle Net Study On Relative Abundance And Habitat Preference Of Elasmobranchs In North Inlet Estuary, South Carolina, Moriah Heather Moore

Electronic Theses and Dissertations

Although habitat selection is relatively well studied in some elasmobranchs, no field or lab studies have focused on sediment preference, which is important to other benthic marine vertebrates. To determine the relative abundance and sediment preference of shallow water benthic elasmobranch inhabitants of North Inlet, SC, we employed 187 30 minute tangle net sets over two sediment types (mud and sand). The majority of our capture consisted of 41 Dasyatis sayi (tagged 37) and 31 Sphyrna tiburo (tagged 14). Although D. sayi had been recorded in North Inlet, previous studies found greater numbers of congeners D. americana and D. sabina. …

Go to article

From The "War On Poverty" To Reagan's "New Right," What's In A Name? : The Symbolic Significance Of The "Welfare Queen" In Politics And Public Discourse., Kem Roper Dec 2012

From The "War On Poverty" To Reagan's "New Right," What's In A Name? : The Symbolic Significance Of The "Welfare Queen" In Politics And Public Discourse., Kem Roper

Electronic Theses and Dissertations

This dissertation is a rhetorical analysis of the political discourse surrounding the role of poor African American women within the American social and political economy beginning in 1965 with Lyndon Johnson's War on Poverty initiatives and extending to the early 1980s with Ronald Reagan and the "religious right." I argue that an ideology of whiteness permeates both the Johnson and Reagan administrations even though each worked towards different ends. In Chapter 1, I begin by discussing how America's establishment as a capitalist society made it a nation ill-fitted for government-funded social programs. In particular, I discuss the impact of distinctions …

Go to article

Zooplankton In Freshwaters : Potential Responses To Global Warming, Nutrient Enrichment, And Exotic Jellyfish., Allison S. Smith Dec 2012

Zooplankton In Freshwaters : Potential Responses To Global Warming, Nutrient Enrichment, And Exotic Jellyfish., Allison S. Smith

Electronic Theses and Dissertations

Aquatic ecosystems face major transformations as humans increasingly alter their environment by introducing exotic species and changing the temperature regime and nutrient availability of freshwater systems. The impacts of such alterations of conditions, resources and species composition on zooplankton are important to consider because zooplankton link primary producers to higher trophic levels. Among recent exotic invaders of freshwater systems in Europe and the Western Hemisphere is Craspedacusta sowerbii. This freshwater cnidarian can impact zooplankton abundance and community composition, thus altering ecosystem energy transfer to higher trophic levels. In experiments described in chapters 2 and 3 of this dissertation, C. sowerbii …

Go to article

Ibrida., Dawn N. Struck Dec 2012

Ibrida., Dawn N. Struck

Electronic Theses and Dissertations

This thesis is a study of my current body of work, both formally and conceptually. It begins with an Introduction, explaining the origin of the term hybrid and the distinct advantages as well as disadvantages hybridization has on a species. It also discusses the effects incurred by the environment on plants and humans. Chapter II, A Curious Collection of Biomorphic Forms, provides an overview of the concepts and interplay between the surface treatments of the forms and their sculpted interior elements and how certain forms reveal, while other forms hide themselves from the viewer. It also confers the motivations behind …

Go to article

Effect Of Viewing Conditions On The Detection Of Proximal Dental Caries In Intraoral Digital Images With And Without Computer-Assisted Diagnosis., Lauren Christine Szechy 1989- Dec 2012

Effect Of Viewing Conditions On The Detection Of Proximal Dental Caries In Intraoral Digital Images With And Without Computer-Assisted Diagnosis., Lauren Christine Szechy 1989-

Electronic Theses and Dissertations

Background: Dental caries is the most common childhood ailment and one of the most prevalent chronic diseases of people worldwide. Approximately 91% of dentate adults 20 years or older have experienced dental caries. Carious lesions on proximal surfaces are particularly difficult to detect clinically, which is why intraoral radiography has become a supplemental method used to aid diagnosis. It was hypothesized that the accuracy of detection of proximal caries with the unaided eye would be reduced in sub-optimal viewing conditions; furthermore, the use of computer-assisted diagnostic software (Logicon Caries Detector) would improve the overall accuracy of observers. Methods: Eighteen radiographs …

Go to article

The Effect Of Implant Placement And Simultaneous Soft Tissue Augmentation In The Esthetic Zone Using Either Connective Tissue Autograft Or Acellular Dermal Matrix Allograft On Peri-Implant Hard And Soft Tissue Healing., Gretchen A. Wigand Dec 2012

The Effect Of Implant Placement And Simultaneous Soft Tissue Augmentation In The Esthetic Zone Using Either Connective Tissue Autograft Or Acellular Dermal Matrix Allograft On Peri-Implant Hard And Soft Tissue Healing., Gretchen A. Wigand

Electronic Theses and Dissertations

Aims. The primary aims of this randomized, controlled, blinded clinical trial were to compare the hard and soft tissue response following either a connective tissue (CT) or acellular dermal matrix (ADM) graft placed simultaneously with a laser-grooved implant. Methods. Twenty-five patients received a single tooth implant in the maxillary anterior that was bordered by two teeth. Patients were randomly selected, using to coin toss, to receive either an ADM (test) or a CT (control) graft. At the 2-month appointment, the implant was uncovered and a lab-fabricated provisional was placed. At the 4-month appointment, following 2 months of tissue shaping, a …

Go to article

Dysregulation Of Microrna Expression In Acquired Endocrine-Resistant Breast Cancer., Tissa Thomas Manavalan Dec 2012

Dysregulation Of Microrna Expression In Acquired Endocrine-Resistant Breast Cancer., Tissa Thomas Manavalan

Electronic Theses and Dissertations

MicroRNAs (miRNAs) regulate gene expression at the post-transcriptional level by repressing translation or stimulating mRNA degradation. In this study, I tested the hypothesis that miRNAs are differentially expressed in antiestrogen-sensitive MCF-7 versus -resistant L Y2 human breast cancer cells. Microarray analyses identified 97 miRNAs that are differentially expressed between two estrogen receptor alpha (ERa) -positive human breast cancer cell lines: endocrine-sensitive MCF-7 versus -resistant L Y2 cells under basal conditions. Opposite expression of miRs-lOa,-21, -22, -12Sb, -181, -200a, -200b, -200c, -221, and -222 was confirmed between MCF-7 and L Y2 cells. The ER antagonist ICI 182,780 (fulvestrant or Faslodex) generally …

Go to article

Integrin Inhibitor Cyclorgdfv Blunts Enhanced Lps-Induced Liver Injury Caused By Ethanol In Mice., Veronica L. Massey Dec 2012

Integrin Inhibitor Cyclorgdfv Blunts Enhanced Lps-Induced Liver Injury Caused By Ethanol In Mice., Veronica L. Massey

Electronic Theses and Dissertations

Background. Progression of alcoholic liver disease (ALD) is associated with an increase in fibrin extracellular matrix (ECM) and inflammation. Previous studies have shown that this accumulation of fibrin in ALD is mediated by impaired fibrinolysis. Additionally, it is known that fibrin(ogen) interacts with the av~3 integrin of endothelial cells. The purpose of this study was to test the hypothesis that hepatic inflammation caused by alcohol is mediated, at least in part, by activation of integrin av~3 by fibrin(ogen). To test this hypothesis, a study was designed to determine the effect of cycloRGDN, a peptide inhibitor of integrin av~3, in a …

Go to article

Intracellular Delivery Of Nanomaterials For Sub-Cellular Imaging And Tracking Of Biomolecules., Krishna Kiran Medepalli Dec 2012

Intracellular Delivery Of Nanomaterials For Sub-Cellular Imaging And Tracking Of Biomolecules., Krishna Kiran Medepalli

Electronic Theses and Dissertations

Nanomaterials have many intriguing applications in biology and medicine. Unique properties such as enhanced electrical properties, increased chemical reactivity and resistance to degradation, novel optical properties and comparable size to that of biological systems have led to their use in various biomedical applications. The most important applications of nanomaterials for medicine are in drug delivery and imaging. This research focuses on utilizing the biocompatibility of single walled Carbon nanotubes (SWCNTs) and optical properties colloidal quantum dots (QDs) for cellular drug delivery and imaging of biomolecules. The first part of this research deals with single walled carbon nanotubes which are excellent …

Go to article

Incorporating Nanomaterials With Mems Devices., Evgeniya V. Moiseeva 1980- Dec 2012

Incorporating Nanomaterials With Mems Devices., Evgeniya V. Moiseeva 1980-

Electronic Theses and Dissertations

This dissertation demonstrates an elegant method, known as 'micro-origami' or strain architecture to design and fabricate three-dimensional MEMS structures which are assembled using actuation of a metal-oxide bilayer with conventional planar lithography. Folding allows creating complex, robust, three-dimensional shapes from two-dimensional material simply by choosing folds in the right order and orientation, small disturbances of the initial shape may also be used to produce different final shapes. These are referred to as "pop-up structures" in this work. The scope of this work presented the deposition of colloidal gold nanoparticles (GNPs) into conformal thin films using a microstenciling technique. Results illustrated …

Go to article

Acetaldehyde Dehydrogenase 2 (Aldh2) Activation Protects Hepatocytes From Mitochondrial Damage And Death Caused By 4-Hydroxynonenal., Keegan J. Baldauf 1982- Dec 2012

Acetaldehyde Dehydrogenase 2 (Aldh2) Activation Protects Hepatocytes From Mitochondrial Damage And Death Caused By 4-Hydroxynonenal., Keegan J. Baldauf 1982-

Electronic Theses and Dissertations

Alcoholic liver disease (ALD) ranks among the major causes of morbidity and mortality in the world and effects millions of patients each year. Progression of ALD is well characterized and is actually a spectrum of liver diseases, which progresses from steatosis, to inflammation and necrosis, to finally fibrosis and cirrhosis. However, the underlying mechanism(s) of ALD are not as well understood, and as a result there is no FDA-approved therapy to prevent or reverse the disease. With a better understanding of the mechanism(s) and risk factors that mediate the initiation and progression of ALD, a targeted therapy can be developed …

Go to article

Ecological Interactions Affecting The Role Of Mosquito Larvae On Dengue Virus Transmission., Jeffrey J. Bara 1984- Dec 2012

Ecological Interactions Affecting The Role Of Mosquito Larvae On Dengue Virus Transmission., Jeffrey J. Bara 1984-

Electronic Theses and Dissertations

In the course of their life cycle, mosquitoes undergo an ontogenetic niche shift; immature larval development occurs within an aquatic habitat from which adult mosquitoes subsequently disperse into the terrestrial environment. While adult female mosquitoes transmit dengue to humans, the larval stage influences dengue virus transmission significantly in several ways. The biotic and abiotic conditions in which larvae develop influence epidemiologically important aspects of adult life history and influence the geographic distribution of mosquito species. Through vertical transmission, mosquitoes may serve as reservoir hosts for dengue during periods that are unfavorable for transmission to humans. For my dissertation, I conducted …

Go to article

Phenomenological Modeling Of Image Irradiance For Non-Lambertian Surfaces Under Natural Illumination., Shireen Y. Elhabian Dec 2012

Phenomenological Modeling Of Image Irradiance For Non-Lambertian Surfaces Under Natural Illumination., Shireen Y. Elhabian

Electronic Theses and Dissertations

Various vision tasks are usually confronted by appearance variations due to changes of illumination. For instance, in a recognition system, it has been shown that the variability in human face appearance is owed to changes to lighting conditions rather than person's identity. Theoretically, due to the arbitrariness of the lighting function, the space of all possible images of a fixed-pose object under all possible illumination conditions is infinite dimensional. Nonetheless, it has been proven that the set of images of a convex Lambertian surface under distant illumination lies near a low dimensional linear subspace. This result was also extended to …

Go to article

The Role Of Endogenous Bcl-Xl In Regulation Of Apoptotic Signaling Pathways., Colins Ogwandi Eno 1982- Dec 2012

The Role Of Endogenous Bcl-Xl In Regulation Of Apoptotic Signaling Pathways., Colins Ogwandi Eno 1982-

Electronic Theses and Dissertations

Bcl-2 proteins are major regulators of cellular responses to various apoptotic stimuli. Among them, overexpression of the anti-apoptotic BcI-2 protein BcI-xL modulates organelle-specific apoptotic pathways. To understand the mechanisms by which endogenous BcI-xL regulates apoptosis, mouse embryonic fibroblasts (MEFs) deficient in BcI-xL expression (Bcl-x-KO) was generated. Studies of BcI-xL exclusively targeted to an organelle in Bcl-x-KO MEFs indicate that the mitochondria- and ER-Iocalized BcI-xL play distinct roles in apoptosis resistance and Ca2+ homeostasis. Specifically, mitochondrial BcI-xL can regulate apoptosis independently of ER BcI-xL, and when localized exclusively at the ER, BcI-xL impinges on Ca2+ homeostasis but does not affect apoptosis …

Go to article

The Use Of Mathematical And Computational Models To Define The Role Of Mutation And Infection In Colorectal Cancer., Chandler D. Gatenbee 1982- Dec 2012

The Use Of Mathematical And Computational Models To Define The Role Of Mutation And Infection In Colorectal Cancer., Chandler D. Gatenbee 1982-

Electronic Theses and Dissertations

Research over the past twenty five years has led to the development of the hypothesis that colorectal cancer is caused by the accumulation of mutations in tumor suppressor genes and proto-oncogenes. The last ten years has also revealed that the common JC Virus (JCV) is frequently found in colorectal tumors. This has led to the hypothesis that the virus, which is known to cause tumors in the lab, may playa role in colorectal cancer. However, the presence of JCV in colorectal tumors does not necessarily indicate a cause-effect relationship. Unlike in vivo and in vitro studies, mathematical and computational modeling …

Go to article

The Dynamic Equilibrium Of Human Telomeric G-Quadruplexes., Robert Buscaglia Dec 2012

The Dynamic Equilibrium Of Human Telomeric G-Quadruplexes., Robert Buscaglia

Electronic Theses and Dissertations

G-quadruplexes are thought to have biological importance, with studies based on small molecule interactions and quadruplex-interactive antibodies demonstrating their potential for formation in vivo. One potential biological function of quadruplex structures is the regulation and maintenance of telomeres. Telomeres are nucleoprotein complexes involved in chromosome stability. Human telomeres are composed of the repeated DNA sequence, 5'- d(TIAGGG), that terminates in a 3' single-stranded overhang. DNA sequences with homology to the human telomere are capable of quadruplex formation in vitro. Specifically, sequences containing four-guanine stretches (e.g. 5'-d(AGGG(TIAGGGb)) are capable of forming at least five distinct unimolecular structures. Which structure is favored …

Go to article

Ridge Preservation Comparing The Clinical And Histologic Healing Of An Intrasocket Allograft Vs. A Facial Overlay Xenograft Using A Bioresorbable Barrier Membrane., Evmenios Poulias Dec 2012

Ridge Preservation Comparing The Clinical And Histologic Healing Of An Intrasocket Allograft Vs. A Facial Overlay Xenograft Using A Bioresorbable Barrier Membrane., Evmenios Poulias

Electronic Theses and Dissertations

Aim. The efficacy of ridge preservation procedures using grafting materials and barrier membranes has been well established in the literature. However, the loss of horizontal width even with the utilization of intrasocket only guided bone regeneration procedures can lead to loss of soft and hard tissue contour or even compromise implant placement. The primary aim of this study was to compare ridge preservation using an intrasocket mineralized particulate cancellous allograft to an intrasocket mineralized particulate cancellous allograft plus a facial overlay with a particulate bovine xenograft, both covered with a bioresorbable barrier membrane. Clinical and histologic data was used to …

Go to article

Morphological Comparison Of Visual Pathway Projections To The Temporal Lobe From Cortical Area Vi And The Tectorecipient Zone Of The Pulvinar Nucleus In The Tree Shrew (Tupaia Belangeri)., Donna Dillihay Dec 2012

Morphological Comparison Of Visual Pathway Projections To The Temporal Lobe From Cortical Area Vi And The Tectorecipient Zone Of The Pulvinar Nucleus In The Tree Shrew (Tupaia Belangeri)., Donna Dillihay

Electronic Theses and Dissertations

The secondary visual pathway, from the retina through the superior colliculus and pulvinar nucleus has been linked to spatial attention (Snow et aI., 2009; Arend et aI., 2008) movement planning and motor response to visual stimuli (Wilke et aI. 2010; Grieve et aI. 2000). The tree shrew temporal cortex receives input from the tecto-recipient pulvinar nucleus, composed of the dorsal (PD) and central (PC) subdivisions (Lyon et al. 2003a). We looked at the projections from this pathway to the temporal cortex and compared them to the VI projections to the temporal cortex in the tree shrew. Our focus was to …

Go to article

Predictive Relationships Of Teacher Efficacy, Geometry Knowledge For Teaching, And The Cognitive Levels Of Teacher Practice On Student Achievement., Paul Klein Dec 2012

Predictive Relationships Of Teacher Efficacy, Geometry Knowledge For Teaching, And The Cognitive Levels Of Teacher Practice On Student Achievement., Paul Klein

Electronic Theses and Dissertations

This study explored the predictive relationships of teacher efficacy, teacher knowledge, and teacher practices with student achievement. More specifically, secondary mathematics teachers' efficacy beliefs, geometry knowledge for teaching, and the cognitive complexity of the teachers' classroom practices were examined for 72 teachers in both urban and rural districts across Kentucky, along with the student achievement data of their students. Teacher and student data were obtained from the NSF-funded Geometry Assessment for Secondary Teachers (GAST) project, which administered geometry teacher knowledge assessments at the beginning and end of the school year, and collected cognitive complexity data from lessons through three classroom …

Go to article

Characterization Of Fhua 104/149c: A Double Cysteine Fhua Mutant With Normal Binding And Diminished Transport, Ada K. Hagan Dec 2012

Characterization Of Fhua 104/149c: A Double Cysteine Fhua Mutant With Normal Binding And Diminished Transport, Ada K. Hagan

Electronic Theses and Dissertations

Iron is an essential element for most bacteria and is commonly acquired by siderophores, molecules secreted under iron restricted environment to bind ferric iron. Gram negative cells actively uptake these complexes via outer membrane-transport proteins such as FhuA in Escherichia coli. Structural analysis of receptors revealed a conserved β-barrel occluded by an N-terminal plug domain. The cell membrane TonB/ExbB/ExbD complex presumably supplies energy via interaction between the FhuA N-terminal TonB box and the C-terminal domain of TonB. In order to better understand the mechanism of action the FhuA mutant 104/149C, tethering the central β-strands 4 and 6 of the …

Go to article

Expectations And Experiences Of Fathers Who Have Parented Children With And Without Intellectual Disabilities, Jane Christina Kusmik Walker Dec 2012

Expectations And Experiences Of Fathers Who Have Parented Children With And Without Intellectual Disabilities, Jane Christina Kusmik Walker

Electronic Theses and Dissertations

The parenting experience is as diverse as the children parented. Each child has diverse personality traits requiring flexibility and specificity in parenting strategy. This need for flexibility and specificity is more complex when one or more children within a family has an intellectual disability. Although research in this area is abundant, investigators have historically focused on mothers' attitudes, beliefs, and behaviors to represent the entire family (Essex, Seltzer, & Krauss, 2001; Greenberg, 2002) rather than focusing on fathers and their caregiving relationships with their children in need of malleable but consistent parenting. Using a qualitative descriptive design, this qualitative study …

Go to article

Regulation Of Vascular Smooth Muscle Cell Phenotype., Joshua Kuimeta Salabei Dec 2012

Regulation Of Vascular Smooth Muscle Cell Phenotype., Joshua Kuimeta Salabei

Electronic Theses and Dissertations

Vascular injury and chronic arterial diseases such as atherosclerosis and restenosis result in exposure of vascular smooth muscle cells (VSMCs) to increased concentrations of growth factors triggering a change from a contractile to a synthetic phenotype. The mechanisms by which growth factors trigger VSMC phenotype transitions remain unclear. Because phenotype switching involves the removal of contractile proteins, we hypothesized that autophagy is an essential modulator of VSMC phenotype. Also, the conversion to the synthetic phenotype is accompanied by cellular changes that trigger metabolic changes to meet the increasing demands for cellular energy. Little is known however about the contributions of …

Go to article

A Model Of Resilience In Children At Risk For The Development Of Anxiety., Matthew David Hartman Schrock Dec 2012

A Model Of Resilience In Children At Risk For The Development Of Anxiety., Matthew David Hartman Schrock

Electronic Theses and Dissertations

Anxiety is a common and debilitating disorder in children. Until recently, research in the field of child anxiety has focused on the identification of specific risk factors in the development of child anxiety. More recent studies have begun to explore more complex models of the etiology of child anxiety, but most still focus on the interplay of risk factors. Studies examining the development of child anxiety should focus on the confluence of vulnerability, risk, and protective factors to provide a more complete picture of the development of child anxiety. The current study reviews current conceptual and empirical research to propose …

Go to article

Role Of Human Arylamine N-Acetyltransferase In Carcinogen Metabolism And Human Breast Cancer Progression., Carmine Simone Leggett Dec 2012

Role Of Human Arylamine N-Acetyltransferase In Carcinogen Metabolism And Human Breast Cancer Progression., Carmine Simone Leggett

Electronic Theses and Dissertations

Human arylamine N-acetyltransferase (NAT) is a phase II cytosolic enzyme that occurs as two isozymes, NAT1 and NAT2. This family of polymorphic enzymes catalyzes the detoxification and/or activation of many aromatic and heterocyclic amine drugs and carcinogens. These metabolism reactions can lead to detoxification of xenobiotics by N-acetylation, or bioactivation by O-acetylation which is preceded by cytochrome P450 (CYP) hydroxylation. This study evaluates the role of human arylamine N-acetyltransferase in carcinogen metabolism as it pertains to substrate selectivity, kinetic activity towards arylamine and alkylaniline substrates, and toxicological risk. Here we introduce the use of immortalized human fibroblasts (GM4429) to investigate …

Go to article

Improved Fabrication And Modeling Of Piezoresistive Microcantilever Beams For Gas Detection And Sensing., Ni Wang Dec 2012

Improved Fabrication And Modeling Of Piezoresistive Microcantilever Beams For Gas Detection And Sensing., Ni Wang

Electronic Theses and Dissertations

Symmetric piezoresistive microcantilever beams have been demonstrated in previous research to be capable of sensing the presence of surrounding gas. This occurs as the damping effect of the gas changes the beam resonance behavior. Device sensitivity has been increased dramatically after changing the symmetric beam base to an asymmetric beam base. This dissertation seeks to improve on beam fabrication and simplify the fabrication procedure compared to earlier approaches. By changing to a polymer mask and using new equipment, an entire wafer can be fabricated in far less time compared to the previous approach. While this new approach shows great promise, …

Go to article

Anxiety In Older Adults With Dementia Residing In Long-Term Care Facilities., Lauren Summer Hess Dec 2012

Anxiety In Older Adults With Dementia Residing In Long-Term Care Facilities., Lauren Summer Hess

Electronic Theses and Dissertations

Dementia, depression, and anxiety are the most common psychiatric disorders among long-term care residents and, because dementia is associated with behavioral problems that can be difficult to manage, the growing number of long-term care residents with dementia and mental health disorders presents a challenge for providing quality care. Research has established the co-occurrence of depression and anxiety and anxiety and agitation in this population. However, a consensus on the conceptualization of the co-occurrence of these constructs has not been reached. It has also been postulated that older adults with dementia may not be able to experience anxiety as conceptualized due …

Go to article

First Prev Next Last