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The Ct20 Peptide As An Agent For Cancer Treatment, Rania Bassiouni
The Ct20 Peptide As An Agent For Cancer Treatment, Rania Bassiouni
Electronic Theses and Dissertations
Due to cancer recurrence and the development of drug resistance, metastatic breast cancer is a leading cause of death in women. In the search for a new therapeutic to treat metastatic disease, we discovered CT20p, an amphipathic peptide based on the C-terminus of Bax. Due to inherent properties of its sequence and similarity to antimicrobial peptides, CT20p is a promising cytotoxic agent whose activity is distinct from the parent protein (e.g. does not cause apoptosis). CT20p is not membrane permeable but can be introduced to cells using polymeric nanoparticles, a method that promotes efficient delivery of the peptide into the …
Differential Expression Of Proteins Involved In Vldl Trafficking Causes Reduced Vldl Secretion In Male Ames Dwarf Mice, Faisal Ahmed Moinuddin
Differential Expression Of Proteins Involved In Vldl Trafficking Causes Reduced Vldl Secretion In Male Ames Dwarf Mice, Faisal Ahmed Moinuddin
Electronic Theses and Dissertations
Cardiovascular diseases (CVDs) have been recorded as the number one cause of death worldwide, accounting for 32% of total deaths annually. More than two-thirds of all CVD cases are associated with atherosclerosis, which is the accumulation of fats and other substances causing plaque formation in the interior walls of major arteries. This leads to narrowing of the lumen and hardening of the arteries, ultimately resulting in angina, heart attack and/or stroke. Studies have shown that the pathogenesis of atherosclerosis and associated CVDs is strongly linked to elevated secretion of liver-specific lipoproteins called very-low-density-lipoprotein (VLDL). VLDLs are crucial lipoproteins responsible for …
Modeling Network Worm Outbreaks, Evan Foley
Modeling Network Worm Outbreaks, Evan Foley
Electronic Theses and Dissertations
Due to their convenience, computers have become a standard in society and therefore, need the utmost care. It is convenient and useful to model the behavior of digital virus outbreaks that occur, globally or locally. Compartmental models will be used to analyze the mannerisms and behaviors of computer malware. This paper will focus on a computer worm, a type of malware, spread within a business network. A mathematical model is proposed consisting of four compartments labeled as Susceptible, Infectious, Treatment, and Antidotal. We shall show that allocating resources into treating infectious computers leads to a reduced peak of infections across …
The Relationship Between Dna's Physical Properties And The Dna Molecule's Harmonic Signature, And Related Motion In Water--A Computational Investigation, Victor Boyer
Electronic Theses and Dissertations
This research investigates through computational methods whether the physical properties of DNA contribute to its harmonic signature, the uniqueness of that signature if present, and motion of the DNA molecule in water. When DNA is solvated in water at normal 'room temperature', it experiences a natural vibration due to the Brownian motion of the particles in the water colliding with the DNA. The null hypothesis is that there is no evidence to suggest a relationship between DNA's motion and strand length, while the alternative hypothesis is that there is evidence to suggest a relationship between DNA's vibrational motion and strand …
Response Of Streamflow And Sediment Loading In The Apalachicola River, Florida To Climate And Land Use Land Cover Change, Paige Hovenga
Response Of Streamflow And Sediment Loading In The Apalachicola River, Florida To Climate And Land Use Land Cover Change, Paige Hovenga
Electronic Theses and Dissertations
Located in Florida's panhandle, the Apalachicola River is the southernmost reach of the Apalachicola-Chattahoochee-Flint (ACF) River basin. Streamflow and sediment drains to Apalachicola Bay in the Northern Gulf of Mexico, directly influencing the ecology of the region, in particular seagrass and oyster production. The objective of this study is to evaluate the response of runoff and sediment loading in the Apalachicola River under projected climate change scenarios and land use / land cover (LULC) change. A hydrologic model using the Soil Water Assessment Tool (SWAT) was developed for the Apalachicola region to simulate daily discharge and sediment load under present …
Examining The Impact Of A Fatigue Intervention On Job Performance: A Longitudinal Study Across United States Hospitals, Megan Gregory
Examining The Impact Of A Fatigue Intervention On Job Performance: A Longitudinal Study Across United States Hospitals, Megan Gregory
Electronic Theses and Dissertations
Fatigue in healthcare providers has been linked to dangerous outcomes for patients, including medical errors, surgical complications, and accidents. Resident physicians, who traditionally work long hours on minimal sleep, are among the most fatigued. In attempt to mitigate the impact of fatigue on resident physician performance and improve patient safety, the Accreditation Council for Graduate Medical Education (ACGME) implemented a fatigue intervention program in 2011 for medical residency programs in the United States. This caused a significant decrease in the number of hours that first-year residents were permitted to work, compared with hours worked by first-year residents in prior years. …
Computational Characterization Of Carboxyphosphate, Traci M. Clymer
Computational Characterization Of Carboxyphosphate, Traci M. Clymer
Electronic Theses and Dissertations
Carboxyphosphate (CP) is an important intermediate involved in reactions catalyzed by acetyl-CoA carboxylase, pyruvate carboxylase, N5-Carboxyaminoimidazole ribonucleotide synthetase, propionyl-CoA carboxylase, urea amidolyase, and carbamoyl phosphate synthetase. Despite its important role, properties for CP have never been reported due to its short estimated half-life (t1/2 70 ms). Thus, the high level ab initio methods, MP2 and CCSD(T), along with the DFT functionals: B3LYP, BB1K, M05-2X, M06-2X, and MPW1K were used to investigate the structure and energetics of CP in both vacuum and the PCM continuum solvation model of water. It was found that CP adopts a novel pseudo-cyclic structure featuring an …
Topographical Differences In Stress Vulnerability In Experimental Parkinson's Disease, Jessica M. Posimo
Topographical Differences In Stress Vulnerability In Experimental Parkinson's Disease, Jessica M. Posimo
Electronic Theses and Dissertations
Parkinson's disease is characterized by the progressive spread of protein misfolding stress, or proteotoxicity, across the brain. During this protracted process, the allocortex of the temporal lobe develops protein inclusions before the neocortex in the frontal and parietal lobes. In the present study we tested the hypothesis that the staged appearance of proteotoxicity in allocortex followed by neocortex is the result of intrinsic vulnerability differences. We microdissected the neocortex and multiple subregions of the allocortex from rat brains and plated the primary neo- and allocortical neurons for parallel in vitro studies. Cells were then exposed to a number of Parkinson's …
Comparison Of A Video Game Based Learning Environment And A Traditional Learning Environment, Jessica Barron
Comparison Of A Video Game Based Learning Environment And A Traditional Learning Environment, Jessica Barron
Electronic Theses and Dissertations
There are many ways to teach within a classroom environment. Traditional teaching methods have been successful because they can be applied in almost any classroom and are useful for imparting knowledge to a learner (Chang & Fisher, 2001). However, understanding and being able to apply that knowledge can be a challenge within a normal classroom environment. Simulations and games have been used in both the past and the present by the military and the government to teach and fine tune desired skills (Balci, Bertelrud, Esterbrook, & Nance, 1997). Video games and simulations give the learner a chance to apply their …
Effect Of Particles On Evaporation Of Droplet Containing Particles, Yan Wei
Effect Of Particles On Evaporation Of Droplet Containing Particles, Yan Wei
Electronic Theses and Dissertations
The evaporation of droplet containing insoluble particles has grown into an active area of research due to the needs for nanofluids for applications in heat transfer, combustion, and manufacturing desired micro/nano particles in the pharmaceutical industry. The evaporation of droplets containing particles involves complicated multiphase heat and mass transport. The evaporation process consists of two stages: the first stage consists of evaporation until a shell of particle forms or when the solid to liquid ratio is sufficiently large and the second stage, where the droplet size is commonly assumed to be unchanged. The dissertation investigates the evaporation kinetics in the …
Drinking Water Infrastructure Assessment With Teleconnection Signals, Satellite Data Fusion And Mining, Sanaz Imen
Drinking Water Infrastructure Assessment With Teleconnection Signals, Satellite Data Fusion And Mining, Sanaz Imen
Electronic Theses and Dissertations
Adjustment of the drinking water treatment process as a simultaneous response to climate variations and water quality impact has been a grand challenge in water resource management in recent years. This desired and preferred capability depends on timely and quantitative knowledge to monitor the quality and availability of water. This issue is of great importance for the largest reservoir in the United States, Lake Mead, which is located in the proximity of a big metropolitan region - Las Vegas, Nevada. The water quality in Lake Mead is impaired by forest fires, soil erosion, and land use changes in nearby watersheds …
Trihalomethane Removal And Re-Formation In Spray Aeration Processes Treating Disinfected Groundwater, Cassandra Smith
Trihalomethane Removal And Re-Formation In Spray Aeration Processes Treating Disinfected Groundwater, Cassandra Smith
Electronic Theses and Dissertations
Historically, chlorination has been widely utilized as a primary and secondary disinfectant in municipal water supplies. Although chlorine disinfection is effective in inactivating pathogenic microbes, the use of chlorine creates the unintentional formation of regulated chemicals. On January 4, 2006, the United States Environmental Protection Agency (EPA) promulgated the Stage 2 Disinfectants/Disinfection by-product rule (DBPR) that focuses on public health protection by limiting exposure to four trihalomethanes (THM) and five haloacetic acids (HAA5), formed when chlorine is used for microbial pathogen control. This thesis examines post-aeration TTHM formation when employing spray-aeration processes to remove semi-volatile TTHMs from chlorinated potable water …
Evaporative Vapor Deposition For Depositing 2d Materials, Kevin Gleason
Evaporative Vapor Deposition For Depositing 2d Materials, Kevin Gleason
Electronic Theses and Dissertations
The development of a new deposition technique called evaporative vapor deposition (EVD) is reported, allowing deposition and formation of atomically-thin, large area materials on arbitrary substrates. This work focuses on the highly popular monolayer material – graphene oxide (GO). A droplet of a GO solution is formed on a heated polymer substrate, and maintained at steady-state evaporation (all droplet parameters are held constant over time). The polymer substrate is laser patterned to control the droplet's contact line dynamics and the droplet's contact angle is maintained using a computer controlled syringe pump. A room temperature silicon wafer is translated through the …
Tidal Hydrodynamic Response To Sea Level Rise And Coastal Geomorphology In The Northern Gulf Of Mexico, Davina Passeri
Tidal Hydrodynamic Response To Sea Level Rise And Coastal Geomorphology In The Northern Gulf Of Mexico, Davina Passeri
Electronic Theses and Dissertations
Sea level rise (SLR) has the potential to affect coastal environments in a multitude of ways, including submergence, increased flooding, and increased shoreline erosion. Low-lying coastal environments such as the Northern Gulf of Mexico (NGOM) are particularly vulnerable to the effects of SLR, which may have serious consequences for coastal communities as well as ecologically and economically significant estuaries. Evaluating potential changes in tidal hydrodynamics under SLR is essential for understanding impacts to navigation, ecological habitats, infrastructure and the morphologic evolution of the coastline. The intent of this research is to evaluate the dynamic effects of SLR and coastal geomorphology …
Characterization Of A Spiking Neuron Model Via A Linear Approach, Amirhossein Jabalameli
Characterization Of A Spiking Neuron Model Via A Linear Approach, Amirhossein Jabalameli
Electronic Theses and Dissertations
In the past decade, characterizing spiking neuron models has been extensively researched as an essential issue in computational neuroscience. In this thesis, we examine the estimation problem of two different neuron models. In Chapter 2, We propose a modified Izhikevich model with an adaptive threshold. In our two-stage estimation approach, a linear least squares method and a linear model of the threshold are derived to predict the location of neuronal spikes. However, desired results are not obtained and the predicted model is unsuccessful in duplicating the spike locations. Chapter 3 is focused on the parameter estimation problem of a multi-timescale …
Critical Programming: Toward A Philosophy Of Computing, John Bork
Critical Programming: Toward A Philosophy Of Computing, John Bork
Electronic Theses and Dissertations
Beliefs about the relationship between human beings and computing machines and their destinies have alternated from heroic counterparts to conspirators of automated genocide, from apocalyptic extinction events to evolutionary cyborg convergences. Many fear that people are losing key intellectual and social abilities as tasks are offloaded to the everywhere of the built environment, which is developing a mind of its own. If digital technologies have contributed to forming a dumbest generation and ushering in a robotic moment, we all have a stake in addressing this collective intelligence problem. While digital humanities continue to flourish and introduce new uses for computer …
Perceived Social Support And Self-Care In Patients Hospitalized With Heart Failure, Lyne Chamberlain
Perceived Social Support And Self-Care In Patients Hospitalized With Heart Failure, Lyne Chamberlain
Electronic Theses and Dissertations
Problem: Heart failure is the most frequent cause for hospital readmissions in Medicare recipients, with an estimated annual cost of $12 billion. Heart failure hospitalizations are also an independent risk factor for increased mortality. Self-care, thought to be enhanced by perceived social support, is key to managing this syndrome, and up to 50% of readmissions are considered the result of inadequate self-care. Purpose: To evaluate perceived social support and self-care characteristics of patients hospitalized with an exacerbation of heart failure, and to compare these characteristics with a study of ambulatory patients with heart failure. In addition, to assess the relationship …
Way Of The Butterfly: A Journey Towards Transformation Through Self-Portraits In-Between, Masami Koshikawa
Way Of The Butterfly: A Journey Towards Transformation Through Self-Portraits In-Between, Masami Koshikawa
Electronic Theses and Dissertations
It has not been easy for me to talk about myself or describe my feelings or thoughts. Coming from Japan, a collective society, we typically are not raised to do so. Throughout the MFA program at UCF, I have shared my feelings and thoughts through my work. It is important to discuss and inform others of our cultural similarities and differences so that we may gain a better understanding of each other. This process has helped me grow not only on an artistic level, but also on a personal level. My journey towards integration has led me to a meaningful …
Body Mass Bias Mitigation For Females In Military Physical Readiness Testing Through Load Carriage Implementation, Aaron Yeaton
Body Mass Bias Mitigation For Females In Military Physical Readiness Testing Through Load Carriage Implementation, Aaron Yeaton
Electronic Theses and Dissertations
The US Military requires specific fitness testing, known as the Physical Readiness Test (PRT), for its members to determine their overall fitness levels. The test currently being used has been shown to have bias towards heavier mass individuals of up to 20%. Prior research has been completed and several recommendations have been made to eliminate mass bias, but this has been conducted almost exclusively on males. There is very little data and research on military physical fitness testing for women besides combat specific evolution exercises. A possibility exists to eliminate the bias for females through implementing load carriage during PRT …
Evaluation Of Strength And Hydraulic Properties Of Buried Pipe Systems Used For Stormwater Harvesting, Mario Samson Mena
Evaluation Of Strength And Hydraulic Properties Of Buried Pipe Systems Used For Stormwater Harvesting, Mario Samson Mena
Electronic Theses and Dissertations
Water scarcity has been identified as a global issue. Both water harvesting and an efficient water piping system are some of the important factors to meet the water demand. In this study, high-density polyethylene (HDPE) pipes used as an underground storage was evaluated and a Microsoft EXCEL based model was developed, called PIPE-R Model. To study the structural integrity of the pipes, laboratory and field testing were conducted. For the water harvesting, UCF Stormwater Management Academy designed an EXCEL based model to simulate the system's performance to store and redistribute water for an average year. The purpose of PIPE-R Model …
Health At Every Size Program Intervention Versus Traditional Weight Loss Intervention: Impact On Diet And Physical Activity, Brooke Noble
Health At Every Size Program Intervention Versus Traditional Weight Loss Intervention: Impact On Diet And Physical Activity, Brooke Noble
Electronic Theses and Dissertations
Backround. A shift from a weight-focus to a health focus -Health At Every Size (HAES)-has been suggested. Yet, little research has compared the impact of this approach to a traditional weight loss program on diet, while physical activity, anthropometric and health indicators have been mixed. Objective. This study evaluated diet, physical activity, anthropometric measurements, blood pressure, blood sugar and cholesterol in participants in these two interventions. It was hypothesized that the HAES group would consume a more nutrient dense diet, more whole foods, higher fiber and lower sodium, while the traditional group would consume lower calories, fat and fiber …
A Comparison Between South Dakota And North American Standard Sampling Gears In Lakes And Reservoirs, Bradley J. Smith
A Comparison Between South Dakota And North American Standard Sampling Gears In Lakes And Reservoirs, Bradley J. Smith
Electronic Theses and Dissertations
A statewide gear comparison was performed in South Dakota during 2013 and 2014 between current South Dakota Department of Game, Fish and Parks (SDGFP) sampling gears (i.e., gill nets and modified fyke nets) and their equivalents described in Standard Methods for Sampling North American Freshwater Fishes (Standard). Adopting Standard gears would provide uniform gear specifications for annual sampling statewide, facilitate data sharing within South Dakota and beyond, and allow for large-scale spatial and temporal analyses relevant to researchers and managers. Sampling was divided between non-Missouri River (non-MR) and Missouri River (MR) systems because gill nets used by SDGFP to sample …
Composing A Literary Adoption Memoir And Self Through Creative Nonfiction Memoir Writing, Jamie K. Nagy
Composing A Literary Adoption Memoir And Self Through Creative Nonfiction Memoir Writing, Jamie K. Nagy
Electronic Theses and Dissertations
Adoption writings span across various forms, such as fiction, non-fiction, essays, poetry, theatre, and scholarly fields of study. While many of these adoption writings speak to the complexities of adoption, the general public still tends to see adoption “such a beautiful thing” to do—as the best plan for the child, a noble act, a selfless decision, and a solution to a long-standing social issue. This thesis explores the “literary adoption memoir”—artful writings about real life happenings; my contribution to this genre addresses the complexities of the closed adoption era, transnational/transracial adoption, and parenting an adoptee as an adult adoptee. For …
Kidquest Childhood Obesity Prevention Program: Analysis Of Its Influence On Health Of Rural South Dakota 5th And 6th Grade Children, Nayef Bumaryoum
Kidquest Childhood Obesity Prevention Program: Analysis Of Its Influence On Health Of Rural South Dakota 5th And 6th Grade Children, Nayef Bumaryoum
Electronic Theses and Dissertations
Obesity is a growing problem throughout the developed world. This project will focus on obesity in rural children by studying those living in an area of South Dakota. Research shows high levels of overweight and obese children in this demographic. The two major objectives of this study are to evaluate the efficacy of the KidQuest (KQ) nutrition and physical activity curriculum in reducing the proportion of children and adolescents who are overweight and obese within participating South Dakota 5th and 6th grade children using baseline/post-intervention data and to determine which KQ teacher type is most effective as evaluated by anthropometric, …
Increasing The Nutritional Value Of Canola Meal Via Fungal Bioprocessing, Jason R. Croat
Increasing The Nutritional Value Of Canola Meal Via Fungal Bioprocessing, Jason R. Croat
Electronic Theses and Dissertations
The main limitation of meals from canola and other Brassica spp. is the presence of glucosinolates (GLS), which are anti-nutritional and can even be toxic at high ingestion levels. Furthermore, large amounts of GLS can reduce palatability for livestock and thus reduce intake and growth rates. For this reason canola was bred to contain lower levels of GLS (<30 >μmol/g) and erucic acid (< 2%). However, feed inclusion rates are still limited to ~30%, and this reduces the value of canola meal. The goal of this thesis was to optimize a pretreatment and fungal conversion process to enhance the nutritional value of canola meal. Various combinations of physical/chemical pretreatments, fungal cultures, and incubation methods were investigated to metabolize GLS into cell mass, CO2, or other non-toxic components. These treatments also served to hydrolyze canola meal fiber into carbohydrates which were then metabolized by the fungi into single cell protein. Solid-state incubation conditions were initially tested, since filamentous fungi are well adapted to grow at lower moisture levels, and this would potentially reduce contamination issues with bacteria. Flask trials were performed using 50% moisture, hexane extracted (HE) or cold pressed (CP) canola meal, with incubation for 168 h at 30ºC. On HE canola meal Trichoderma reesei (NRRL-3653) achieved the greatest increase in protein content (23%), while having the lowest residual levels of sugar (8% w/w) and GLS (0.4 μM/g). On CP canola meal T. reesei (NRRL-3653), Aureobasidium pullulans (NRRL-58522), and …
Virus-Like Particles Generaged By Expressing Proteins Of Porcine Reproductive And Respiratory Syndrome Virus (Prrsv) Using The Recombinant Baculovirus Expression System, April Anne Nelsen
Virus-Like Particles Generaged By Expressing Proteins Of Porcine Reproductive And Respiratory Syndrome Virus (Prrsv) Using The Recombinant Baculovirus Expression System, April Anne Nelsen
Electronic Theses and Dissertations
Porcine reproductive and respiratory syndrome virus (PRRSV) is an enveloped, single stranded, positive sense RNA virus and a member of Arteriviridae. Its genome encodes 10 open reading frames for at least 7 structural proteins and 14 non-structural proteins. Membrane (M), Nuclepcapsid (N), and Glycoprotein-5 (GP5) are the major structural proteins of PRRSV, while Envelope (E), Glycoprotein-2 (GP2), Glycoprotein-3 (GP3), and Glycoprotein-4 (GP4) are the minor structural proteins of PRRSV. GP5 induces neutralizing antibodies and forms heterodimers with M, while N is the most immunogenic protein of PRRSV. Previous studies have shown viral structural proteins are able to form virus-like particles …
An Economic Analysis Of High-Intensity, Short-Duration Grazing Systems In South Dakota And Nebraska, Bronc Mcmurtry
An Economic Analysis Of High-Intensity, Short-Duration Grazing Systems In South Dakota And Nebraska, Bronc Mcmurtry
Electronic Theses and Dissertations
Four different grazing systems: two rotational, a continuous, and a high-intensity, short-duration (mob) system, replicated twice, were evaluated from an economic perspective. Mob grazing is defined as a system having very high stocking rates for a small amount of time. Livestock are forced to eat or trample the vegetation. Stocking rates and average daily gains (ADG) were collected from the UNL Barta Brothers ranch near Rose, Nebraska. The study started in 2011 and lasted until 2014. Using the performance data and other cost data relevant to South Dakota and Nebraska, budgets were set up for each system and extrapolated to …
Effects Of Processing Conditions On Nutritional Quality And Glucosinolate Concentration Of In Vitro Incubations Of Several Oilseed Meals, Adolf N.O. Sackey
Effects Of Processing Conditions On Nutritional Quality And Glucosinolate Concentration Of In Vitro Incubations Of Several Oilseed Meals, Adolf N.O. Sackey
Electronic Theses and Dissertations
Studies were conducted to evaluate nutritional characteristics of three oilseed meals. Camelina and carinata meals were either cold-pressed or hexane-extracted and manufactured by 6 different processing conditions within extraction method. Flaxseed meals were either cold-pressed or solvent extracted and their processing condition unknown. Results are intended to provide helpful information for both processors producing meals and producers desiring to use these meals in livestock diets. The first set of studies was designed to determine a modification to the Tilley and Terry in vitro procedure that would generate adequate material for multiple analyses on residue of oilseed meals without compromising IVDMD. …
Drought Resistance And Resilience Of Non-Native Vs. Native Grasses In The Northern Tallgrass Prairie, Wyatt Kirwan
Drought Resistance And Resilience Of Non-Native Vs. Native Grasses In The Northern Tallgrass Prairie, Wyatt Kirwan
Electronic Theses and Dissertations
Drought can have major impacts on rangeland productivity and remains highly unpredictable. Like many other rangelands in the US, the Tallgrass Prairie of eastern South Dakota contains native prairie where the plant composition includes mostly native species as well as pasture that has been converted to or invaded by cool-season introduced species. So how are these two plant communities impacted by drought? The specific objective of this study was to compare drought resistance and drought resilience of native prairie to introduced cool-season pasture (Smooth brome - Bromus inermis and Kentucky bluegrass - Poa pratensis). Our Hypothesis was that native prairie …
Population Ecology Of Rocky Mountain Elk In The Black Hills, South Dakota And Wyoming, Benjamin D. Simpson
Population Ecology Of Rocky Mountain Elk In The Black Hills, South Dakota And Wyoming, Benjamin D. Simpson
Electronic Theses and Dissertations
We conducted a 2-year (2012–2013) study of survival and cause–specific mortality using individually marked adult cow and neonate elk (Cervus elaphus) occupying the southwestern region of the Black Hills. We used known-fate analysis in Program MARK for survival analysis of adult cows and calves. We estimated survival and cause-specific mortality of 49 adult female elk over the 2 years of the study. Annual adult cow survival was 0.85 (95% CI = 0.72–0.87). We documented 12 mortalities with harvest (58.3%) and predation (16.6%) accounting for the majority of known mortalities. We captured and fit 71 neonates < 10 days of age with expandable Very High Frequency (VHF) radiocollars during summer 2012 (n = 37) and 2013 (n = 34). Annual (12 month) survival of elk calves was 0.75 (95% CI = 0.61–0.84) while summer (20 weeks; 15 May–25 September) survival was 0.79 (95% CI = 0.68–0.88). Predation accounted for 87.5% of mortalities; remaining mortalities were from starvation (6.3%) and unknown (6. 3%) causes. We used Global Positioning System (GPS) collars to collect 167,707 locations to determine home range, movement ecology, and macroscale resource selection of 48 adult cow elk. We documented elk using a variety of migration strategies (obligate migrator, resident, conditional migrator, disperser); the majority of the population (58%) was migratory. Spring migration distance travelled ranged from 2.45 km – 74.44 km (n = 42); fall migration distances ranged from 6.41km – 153.95 km (n = 46). We used 99% Brownian Bridge Movement Models to create seasonal and overall home ranges of adult cow elk. Mean overall home range size for conditional migrators was 249.28 km2 (SE = 28.60, n = 7, range = 233.75), for obligate migrant elk it was 227.18 km2 (SE = 13.94, n = 29, range = 346.83), and for resident elk it was 175.65 km2 (SE = 22.75, n = 11, range = 216.04). We used discrete choice models to determine resource selection at the macro-habitat scale of collared adult elk using ArcMap 10.1 data. Adult cow elk selected for open grassland/herbaceous areas and early successional forest areas close to forested edges at higher elevations. Our study showed that elk populations have the ability to thrive within an ecosystem with healthy predator populations.