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Colony Stimulating Factor-1 Receptor (Csf-1r) Expression, Degradation, And Signaling In Lipid-Laden Macrophages, Gregory Thompson Jan 2016

Colony Stimulating Factor-1 Receptor (Csf-1r) Expression, Degradation, And Signaling In Lipid-Laden Macrophages, Gregory Thompson

Electronic Theses and Dissertations

Atherosclerosis is a serious disease affecting a large portion of the world’s population. In atherosclerosis, macrophages become filled with lipid droplets and form fatty plaques in artery walls. The formation of these atherosclerotic plaques is dependent on the macrophage growth factor colony stimulating factor-1 (CSF-1); however, understanding the changes in CSF-1 signaling and related pathways in foam cells remain poorly investigated. Lipid-laden macrophages were formed through exposure of murine bone marrow derived macrophages to 100 μg/ml acetylated LDL for 24 h. Non-LDL treated macrophages were grown in parallel for each experiment and used for comparison. Immunofluorescent staining was used to …

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Pilot Study Of The Effects Of Heart Rate Variability Biofeedback On Perceived Stress, Perceived Coping Ability, And Resilience In Accelerated Baccalaureate Nursing Students, Andrea J. Harmelink Jan 2016

Pilot Study Of The Effects Of Heart Rate Variability Biofeedback On Perceived Stress, Perceived Coping Ability, And Resilience In Accelerated Baccalaureate Nursing Students, Andrea J. Harmelink

Electronic Theses and Dissertations

Objective. The purpose of this quasi-experimental randomized controlled two-group pilot study was to test the effectiveness of a Heart Rate Variability Biofeedback (HRVB) intervention on accelerated baccalaureate nursing (ABN) students’ perceived stress, perceived coping ability, and resilience over four weeks during an academic term of ABN coursework. This study was guided by Lazarus and Folkman’s Transactional Theory of Stress and Coping, with a focus on primary appraisal.
Background. ABN students report higher perceived stress and anxiety compared with nursing students in traditional four-year nursing programs due to the compressed and fast-paced format of the ABN curriculum. Qualitative data points to …

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Corncob Grit Application As An Alternative To Control Weeds In Two Crop Production Systems, Mauricio Erazo-Barradas Jan 2016

Corncob Grit Application As An Alternative To Control Weeds In Two Crop Production Systems, Mauricio Erazo-Barradas

Electronic Theses and Dissertations

Weed management is one of the most challenging production problems in organic cropping systems because of limited weed control methods. Grits, derived from agricultural residues, have been demonstrated to control weed seedlings selectively in corn. This research examined weed efficacy and crop yield of an integrated air-propelled abrasive corncob grit (for in-row weed control) at varying timings and frequencies and flame-weeding or cultivation (for between-row weed control) system in two corn production systems. In the first study efficacy of weed control was assessed with this approach in an organic corn silage production system established in Morris, MN in 2013 and …

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Inactivation Of Thermodynamic Sporeformers And Spores In Skim Milk By Continuous Ultrasonication And Hydrodynamic Cavitation In Combination With Thermal Treatments, Dikshi Bawa Jan 2016

Inactivation Of Thermodynamic Sporeformers And Spores In Skim Milk By Continuous Ultrasonication And Hydrodynamic Cavitation In Combination With Thermal Treatments, Dikshi Bawa

Electronic Theses and Dissertations

Studies were conducted to determine the effectiveness of ultrasonication and hydrodynamic cavitation, in a continuous mode, alone and in combination with thermal treatments, on heat resistant aerobic sporeformers and spores in skim milk, and skim milk concentrate. The first study was conducted to investigate the effectiveness of a continuous ultrasonication process to reduce thermoduric Bacillus coagulans cells in skim milk. A 25% reduction was obtained by lab pasteurization alone, whereas ultrasonication alone resulted in an inactivation of 92% after 12 passes (80 sec exposure time per pass). Ultrasonication when combined with pasteurization resulted in further increased inactivation to 99.98%. It …

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Impact Of New Processing Technologies On The Physical And Functional Properties Of Skim Milk And Skim Milk Concentrate, Harsh Dahiya Jan 2016

Impact Of New Processing Technologies On The Physical And Functional Properties Of Skim Milk And Skim Milk Concentrate, Harsh Dahiya

Electronic Theses and Dissertations

United States is one of the largest producer of cow’s milk in the world and a substantial portion of this milk is converted into dried milk products, a category that is becoming increasingly important to the dairy industry. The processing treatments on skim milk and skim milk concentrate affect the functionality of resultant powders made from them, therefore processing treatments are crucial to modify physical and functional properties of skim milk, skim milk concentrates and the powders made from them. The objective of this research was to explore impact of new processing technologies hydrodynamic cavitation (HC) and carbon dioxide (CO2) …

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Evaluation Of Essential Oils (Stay Strong) For Dairy Calves, Kelly Ann Froehlich Jan 2016

Evaluation Of Essential Oils (Stay Strong) For Dairy Calves, Kelly Ann Froehlich

Electronic Theses and Dissertations

Stay Strong (SS, Ralco Inc., Marshall, MN) is a blend of essential oils (EO) and prebiotic fiber technologies designed to promote immunity and stimulate appetite, helping to diminish health challenges and stresses experienced by newborn calves. Current feeding inclusion rates are unknown to achieve optimal performance in the first 8 weeks of life. The study objectives were to determine the optimal feeding inclusion rate of SS when added to milk replacer (MR) to achieve optimal performance when compared to a yeast cell wall (YCW). One hundred Holstein calves were blocked by birth date and randomly assigned to 1 of 5 …

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Evaluation Of Tillage, Crop Rotation, And Cover Crop Impacts On Corn Nitrogen Requirements In Southeastern South Dakota, Sara Louise Berg Jan 2016

Evaluation Of Tillage, Crop Rotation, And Cover Crop Impacts On Corn Nitrogen Requirements In Southeastern South Dakota, Sara Louise Berg

Electronic Theses and Dissertations

Nitrogen (N) is a vital factor of corn (Zea mays) production. Previous work in South Dakota has shown that there is uncertainty as to whether nitrogen requirements are the same for corn raised under no-till (NT) versus conventional till (CT) production systems. The objective of this study was to evaluate whether N requirements continue to be greater under long-term NT versus CT production systems in southeastern South Dakota, while also considering effects from cover crops and crop rotation. This was a two year study conducted at the SDSU Southeast Research Farm near Beresford, SD; it was superimposed on a long-term …

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Measuring And Understanding Health-Related Quality Of Life Among Adult Patients With Hemophilia, Ruchit Mukesh Shah Jan 2016

Measuring And Understanding Health-Related Quality Of Life Among Adult Patients With Hemophilia, Ruchit Mukesh Shah

Electronic Theses and Dissertations

Objectives: The objectives of this study are to: 1) examine the psychometric properties of the Medical Outcomes Study Short Form-12 Version 2 (SF-12v2); 2) assess the measurement invariance of the SF-12v2 with respect to age, disease severity, and treatment regimen; 3) identify psychosocial predictors of health-related quality (HRQOL) among adults with hemophilia in the United States. Methods: This cross-sectional study was conducted using both a web-based and paper-based self-administered survey. Adults with hemophilia were recruited using an online panel, a Facebook community of hemophilia patients, and at the University of Mississippi Medical Center hemophilia treatment clinic. Psychometric properties of the …

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Identifying Values: Comparing Four Methods Of Values Identification, Emmie Hebert Jan 2016

Identifying Values: Comparing Four Methods Of Values Identification, Emmie Hebert

Electronic Theses and Dissertations

Values have been described, from a behavioral perspective, as “freely chosen, verbally constructed consequences of ongoing, dynamic, evolving patterns of activity, which establish predominant reinforcers for that activity that are intrinsic in engagement in the valued behavioral pattern itself “ (Wilson & DuFrene, 2009). Emerging research supports the psychological benefits of interventions with a values component. However, there has been little experimental research that explores systematic methods of getting participants and psychotherapy clients to identify their values. This study evaluated four methods of identifying values by comparing within-subject ratings of participant-generated values stimuli. Participants were undergraduate students at the University …

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Scrupulosity, Trauma And Disgust, Oh My! Assessing The Potential Relation Between Religiosity, Trauma Symptoms And Disgust, Brooklee Lightsey Tynes Jan 2016

Scrupulosity, Trauma And Disgust, Oh My! Assessing The Potential Relation Between Religiosity, Trauma Symptoms And Disgust, Brooklee Lightsey Tynes

Electronic Theses and Dissertations

Lifetime prevalence rates for Posttraumatic Stress Disorder (PTSD) are estimated to be 6% in the general population. In the United States alone, an estimated 5.2 million adults will experience PTSD within the year (National Comorbidity Survey, 2005). However, a much larger number of the population will experience some form of trauma over the course of their lifetime. Research has demonstrated that the development of PTSD may be attributed to some factors (e.g., temperamental vulnerabilities, social ecological factors), which may predispose individuals to the development of the disorder. The purpose of this study was to test the association of moral disgust …

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Is Your Parenting Style Hindering Your Child’S Chances At Succeeding In Their Post-Seconday Education? A Pilot Study Of Parent Gender And Parenting Style Effects On College Student Adjustment, Natya Jones Jan 2016

Is Your Parenting Style Hindering Your Child’S Chances At Succeeding In Their Post-Seconday Education? A Pilot Study Of Parent Gender And Parenting Style Effects On College Student Adjustment, Natya Jones

Electronic Theses and Dissertations

Research was conducted on parent gender and parenting style effects on college student adjustment. Literature suggest that an authoritative parenting style is most optimal for adolescent outcomes contributing to adjustment in the following ways: social, attachment, personal emotional and academic. The current study utilized a convenience sample of 52 participants that examined the associations of parent gender and perceive parenting styles on college student adjustment. Significant relations were found among the differences between maternal and paternal permissive parenting on overall student adjustment.

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Sookie's Place(S): New Roadways Into The South Of The Southern Vampire Mysteries, Sarah Holder Jan 2016

Sookie's Place(S): New Roadways Into The South Of The Southern Vampire Mysteries, Sarah Holder

Electronic Theses and Dissertations

Charlaine Harris’ bestselling paranormal romance series, the Southern Vampire Mysteries is only beginning to be understood as more than a cultural phenomenon, but rather as a highly politicized and critical work of fiction that shines through genre designations such as romance, mystery, and fantasy. Much of this praise can be attributed to the series’ heroine, Sookie Stackhouse, who gracefully traverses boundaries that divide what are arguably racial and ethnic groups ever at odds with one another as they share political and social space. Her adventures therefore pose significant questions concerning diversity, equality, and nationalism, but more obviously they ask what …

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Competitive Effects Of Increased Plant Species Richness And Increased Endemic Versus Native Generalist Species Dominance On The Invasive Grass Microstegium Vimineum During Oak Woodland Restoration, Sean Anthony Moyer Jan 2016

Competitive Effects Of Increased Plant Species Richness And Increased Endemic Versus Native Generalist Species Dominance On The Invasive Grass Microstegium Vimineum During Oak Woodland Restoration, Sean Anthony Moyer

Electronic Theses and Dissertations

The hypothesis that species-rich assemblages are resistant to invasion by non-native species has generated considerable research and controversy. However, the relevance of such research to the conservation of biodiversity is questionable, given that local species richness often does not correlate with regional or global species richness, two metrics undoubtedly important to conservation. Furthermore, species of greater conservation interest (i.e. endemics) and widespread generalist species may compete differentially with non-native invasive species. To test whether plant species richness or species fidelity to a regionally rare habitat were more important in competitively suppressing an invasive species, I established a field competition experiment …

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Community Ecology Of Soil Microbes In Southeast Usa Oak-Pine Woodlands, Ann L. Rasmussen Jan 2016

Community Ecology Of Soil Microbes In Southeast Usa Oak-Pine Woodlands, Ann L. Rasmussen

Electronic Theses and Dissertations

Soil microbial communities can have important effects on plant growth and plant community ecology; however, the relationships between trees and soil microbial communities are still relatively poorly understood. Here i examine several of these relationships. Chapter 1 examines how ecological restoration and environmental conditions affect the community composition and enzyme activities of Ectomycorrhizal fungi (emf). Chapter 2 considers whether host specificity in emf structures taxa occurrence on oaks and pines, and chapter 3 investigates how ash addition affects oak seedling growth and the soil bacterial community. I found that while wildfire lowered emf diversity, prescribed burning did not. Ectomycorrhizal root …

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Characterization Of Charge Accommodation In Biologically Important Hydrogen-Bonded Clusters, John Thomas Kelly Jan 2016

Characterization Of Charge Accommodation In Biologically Important Hydrogen-Bonded Clusters, John Thomas Kelly

Electronic Theses and Dissertations

The underlying motivation of chemical physics and physical chemistry is to understand naturally occurring chemical and physical processes from the nanoscopic molecular level to the macroscopic condensed phase. Over the past half-century, experimentalists have developed a number of laser-based analytical techniques to bridge the gap between the bulk phase and the single molecule. Here, we look at bulk phase and gas phase clusters to compare the local hydrogen-bonded network. To better understand the role noncovalent interactions have on biologically relevant building blocks in a natural environment, we compare the microhydration of gas phase cluster ions to condensed phase spectra. The …

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Genetic And Temporal Variation In Resource Exchange Between An Ectomycorrhizal Fungus, Rhizopogon Occidentalis, And Seedlings Of Pinus Radiata, Mariah Meachum Jan 2016

Genetic And Temporal Variation In Resource Exchange Between An Ectomycorrhizal Fungus, Rhizopogon Occidentalis, And Seedlings Of Pinus Radiata, Mariah Meachum

Electronic Theses and Dissertations

Various economic theories have been adapted to explain the evolutionary persistence of resource exchange mutualisms such as mycorrhizae. The ratio of resources exchanged is an important variable comto all these models. Measuring resource exchange ratios is the first step in testing the hypotheses predicted by these models and will provide insight into resource dynamics of mutualisms. We examined how the carbon, nitrogen and phosphorus resource exchange dynamics between Pinus radiata and an ectomycorrhizal fungus, Rhizopogon occidentalis, varied between native populations of Pinus radiata and over the first 64 weeks of the mycorrhizal mutualism. Using a mycocosm approach, the C:N and …

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Loblolly Pine Genetics Structure Its Mycorrhizal Community, Bridget Joan Piculell Jan 2016

Loblolly Pine Genetics Structure Its Mycorrhizal Community, Bridget Joan Piculell

Electronic Theses and Dissertations

Plant populations are constantly exposed to a multitude of biotic and abiotic environmental selection pressures. The ability of a population to persist in or adapt to its environment is heavily influenced by the genetic underpinnings of the traits involved. Thus, in order to understand patterns in current plant populations, and to predict future populations dynamics, an understanding of the genetic basis of adaptive traits is necessary. For example, genetic correlations between traits (driven by pleiotropy or linkage disequilibrium) could influence how species evolve under multiple, conflicting selection pressures, potentially either constraining or enhancing the adaptation of species to each other. …

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Raft Polymerization Of Ph-Responsive, Diblock Copolymers For Nucleic Acid Delivery Vehicles, Annie Katherine Mcclellan Jan 2016

Raft Polymerization Of Ph-Responsive, Diblock Copolymers For Nucleic Acid Delivery Vehicles, Annie Katherine Mcclellan

Electronic Theses and Dissertations

Since the development of gene therapy, a variety of non-viral nucleic acid delivery vehicles have been prepared and studied for their transfection efficiencies. Recently, polymeric gene delivery vehicles have gained popularity for their low immunogenicity and high transfection efficiency. With the advent of controlled radical polymerization (CRP) and more specifically reversible addition-fragmentation chain transfer (RAFT) polymerization, it is now possible to develop well-defined polymers with predicted molecular weights and architectures. The work presented here focuses on the RAFT polymerization of a family of amphiphilic, cationic copolymers to be utilized for nucleic acid delivery. These copolymers are composed of a stabilizing …

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Gas Exchange Of Hg Over Wetlands, Effect Of Biochar And Activated Carbon On Hg Emissions From Soil, And Seasonal Concentrations Of Hg In Rain, Divya Nallamothu Jan 2016

Gas Exchange Of Hg Over Wetlands, Effect Of Biochar And Activated Carbon On Hg Emissions From Soil, And Seasonal Concentrations Of Hg In Rain, Divya Nallamothu

Electronic Theses and Dissertations

Mercury (Hg) is a global pollutant with human-health and ecological impacts. Gaseous Hg exchange between the atmosphere and aquatic or terrestrial surfaces serves as an important, but not well understood, route for Hg to enter and exit ecosystems. To better understand the role of gaseous Hg exchange in the biogeochemical cycling of Hg, we investigated Hg0 fluxes over natural wetlands (Sky Lake) and artificial wetlands (UM Field Station) using a dynamic flux chamber and an Hg vapor analyzer based on atomic fluorescence (Chapter 1). We also examined the effect of activated carbon and biochar on Hg emissions from soils for …

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Multi-Scale Nanoindentation For Characterization Of Oil Shales, Zachary N. Miller Jan 2016

Multi-Scale Nanoindentation For Characterization Of Oil Shales, Zachary N. Miller

Electronic Theses and Dissertations

Studies of the effects of polishing techniques, scale of nanoindentation, and petrophysical properties were conducted on both Woodford and Tuscaloosa Marine Shale. Polishing procedures include both an in-house developed, mechanical sample preparation protocol as well as ion beam milling. The elastic modulus and hardness of each mechanically polished sample was found to have larger value than those that were ion-milled. Additionally, at low loads, the samples resulted in having high standard deviation. This high deviation was found to be significantly reduced by testing at higher loads. The variations in results between mechanically polished and ion beam milled samples is believed …

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Validation Of Integrated Coast-Ocean Model Cche2d-Coast And Development Of Wind Model, Afshin Gazerzadeh Jan 2016

Validation Of Integrated Coast-Ocean Model Cche2d-Coast And Development Of Wind Model, Afshin Gazerzadeh

Electronic Theses and Dissertations

The eastern and southern coastlines of the United States are two of the most cyclone-prone areas of the world. The effects of tropical cyclones vary mainly depending on wind intensity and geological features of the coast that it is crossing. Higher winds potentially generate higher storm surges and consequently larger floods occur along the coastlines. Therefore, it is critical to accurately predict winds, storm surge, and waves associated with a hurricane. In the present study, an integrated coastal and ocean process model, CCHE2D-Coast, is validated by assessing the model’s capabilities in simulating coast-ocean circulations driven by the astronomical tides on …

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The Effect Of Hyperparameters In The Activation Layers Of Deep Neural Networks, Clay Lafayette Mcleod Jan 2016

The Effect Of Hyperparameters In The Activation Layers Of Deep Neural Networks, Clay Lafayette Mcleod

Electronic Theses and Dissertations

Deep neural networks (DNNs), and artificial neural networks (ANNs) in general, have recently received a great amount of attention from both the media and the machine learning community at large. DNNs have been used to produce world-class results in a variety of domains, including image recognition, speech recognition, sequence modeling, and natural language processing. Many of most exciting recent deep neural network studies have made improvements by hardcoding less about the network and giving the neural network more control over its own parameters, allowing flexibility and control within the network. Although much research has been done to introduce trainable hyperparameters …

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Predisposing Risk Factors Associated With Stress Fracture Development In Division I Cross Country Runners, Kaci Griffin Jan 2016

Predisposing Risk Factors Associated With Stress Fracture Development In Division I Cross Country Runners, Kaci Griffin

Electronic Theses and Dissertations

The purpose of this study was to explore potential factors that could be associated with increased stress fracture development in division one collegiate cross country runners. Participants for this study consisted of 42 collegiate cross country runners at the University of Mississippi. A nutritional assessment consisting of a 3-day food record and measurements of whole body, lumbar spine and hip bone mineral densities using a Dual-Energy X-ray Absorptiometry (DXA) was conducted on each athlete. Each athlete was also asked to answer a demographic questionnaire with questions regarding ethnicity, hometown, smoking status, vitamin/mineral intake, previous stress fracture history, birth control usage …

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Physiological And Perceptual Responses To Alternate Modes Of Exercise At Self Selected Or Prescribed Intensity Between Overweight And Non-Overweight Individuals, James Riley Galloway Jan 2016

Physiological And Perceptual Responses To Alternate Modes Of Exercise At Self Selected Or Prescribed Intensity Between Overweight And Non-Overweight Individuals, James Riley Galloway

Electronic Theses and Dissertations

Purpose: To investigate the influence of body weight, exercise modality, and pace on physiological and perceptual responses during walking. Also, to determine if the relationship between physiological and perceptual responses was altered by modality, pace, or weight status. Methods: Aerobically untrained males (n=80, 22.85 ± 3.61 years) and females (n=80, 21.18 ± 1.52 years) classified as either overweight or non-overweight participated. Individuals completed two sessions separated by 72 hours. Session 1 included familiarization, whole body DXA scan, treadmill test to exhaustion, and a 70 foot walk test to determine self selected walking speed. For session 2, participants were randomly assigned …

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The Corruption Of Promise: The Insane Asylum In Mississippi, 1848-1910, Whitney E. Barringer Jan 2016

The Corruption Of Promise: The Insane Asylum In Mississippi, 1848-1910, Whitney E. Barringer

Electronic Theses and Dissertations

The ideology of insane asylum reform, which emphasized the Enlightenment language of human rights and the humane treatment of the mentally ill, reached American shores in the early-mid-nineteenth century. When asylum reform began to disseminate throughout the United States, forward-thinking Mississippians latched onto the idea of the reformed asylum as a humane way to treat mentally ill Mississippians and to bolster the humanitarian image of a Southern slave society to its Northern critics. When the Mississippi State Lunatic Asylum opened in 1855, its superintendents were optimistic about the power of the state to meet mental healthcare needs. While Mississippi slave …

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Comparing University Student Performance In Online V. Face-To-Face Offerings Of The Same Course, And Investigating Student Perceptions Of Satisfaction In An Online Course, Kristin Davidson Jan 2016

Comparing University Student Performance In Online V. Face-To-Face Offerings Of The Same Course, And Investigating Student Perceptions Of Satisfaction In An Online Course, Kristin Davidson

Electronic Theses and Dissertations

Online education in the United States has seen dramatic growth for the past decade, outpacing any other growth in higher education. The concurrent mixed-methods study that was conducted for this research used data from a survey geology course taught in both environments, online and traditional face-to-face. The quantitative research focused on comparing student performance in an online course relative to the same face-to-face course, while the qualitative research investigated how students described their experiences taking an online class. Previous work in online education has been limited by relatively small sample sizes, conducting studies over just one semester, comparing dissimilar courses …

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Cavaliers And Crackers: Landless Whites In The Mind Of The Elite Antebellum South, Jeffrey Glossner Jan 2016

Cavaliers And Crackers: Landless Whites In The Mind Of The Elite Antebellum South, Jeffrey Glossner

Electronic Theses and Dissertations

Due to their marginalized role in southern society, landless white southerners have often been overlooked by historians who study social class, politics and intellectual culture in the antebellum south. But depictions of landless white southerners were prominent in contemporary elite literature and their place was debated extensively by social commentators. These depictions marginalized landless whites from southern honor culture and marked them as a people who were not quite white in a social and biological sense. This characterization was both a cause and effect of elite southern unease with the presence of a class of poor landless whites. This unease …

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Exaggerated News Headlines And The Continued Influence Effect, Heather Nicole Bliss Jan 2016

Exaggerated News Headlines And The Continued Influence Effect, Heather Nicole Bliss

Electronic Theses and Dissertations

No abstract provided.

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Saffron Extract And Its Active Constituents As Preventative And/Or Treatment Agents For Prostate Cancer Using In Vitro And In Vivo Models, Faisal Fayih Albaqami Jan 2016

Saffron Extract And Its Active Constituents As Preventative And/Or Treatment Agents For Prostate Cancer Using In Vitro And In Vivo Models, Faisal Fayih Albaqami

Electronic Theses and Dissertations

Saffron extract and its active constituents were evaluated as chemopreventatives and/or treatments for prostate cancer. Different models of prostate cancer (in vitro and in vivo) were used for studying saffron and its constituents’ mechanisms. In normal prostate cells, saffron extract, crocetin, and safranal, in non-toxic concentrations, possessed antioxidant properties against the reactive oxygen species induced by H2O2 which further supports saffron constituents as chemopreventative agents. Moreover, saffron and its active constituents produced cytotoxicity in prostate cancer cells through intrinsic apoptosis pathways. Potential efficacy in minimizing prostate cancer metastasis was also examined. Saffron extract, crocetin, and safranal decreased the migration and …

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Targeting Protein Kinases To Manage Or Prevent Alzheimer’S Disease, Manal A. Nael Jan 2016

Targeting Protein Kinases To Manage Or Prevent Alzheimer’S Disease, Manal A. Nael

Electronic Theses and Dissertations

Due to the pressing need for new disease-modifying drugs for Alzheimer’s disease (AD), new treatment strategies and alternative drug targets are currently being heavily researched. One such strategy is to modulate protein kinases such as cyclin-dependent kinase 1 (CDK1), cyclin-dependent kinase 5 (CDK5), glycogen synthase kinase-3 (GSK-3α and GSK-3β), and the protein kinase RNA-like endoplasmic reticulum kinase (PERK). AD intervention by reduction of amyloid beta (Aβ) levels is also possible through development of protein kinase C-epsilon (PKC-ϵ) activators to recover α-secretase levels and decrease toxic Aβ levels, thereby restoring synaptogenesis and cognitive function. In this way, we aim to develop …

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