Digital Commons Network^™

Psychological And Sociocultural Influences Of Current And Historical Intimate Partner Violence In Pregnancy, Cindy D. Phillips

Electronic Theses and Dissertations

The Centers for Disease Control and Prevention (CDC) estimates that 1.5 million women are victims of intimate partner violence (IPV) each year, and 324,000 of these women are pregnant (2013). Research on the predictability of certain factors and their relationship to current and historical IPV is limited. In order to better understand IPV as it related to a sample of 1,016 Appalachian pregnant women selected for the Tennessee Interventions for Pregnant Smokers (TIPS), it was important to evaluate various influences that may predict the prevalence of IPV in this population when compared to the State of Tennessee and the U.S. …

Sa-4-1bbl As A Modulator Of Innate, Adaptive, And Regulatory Immunity : Implications For Cancer Prevention And Treatment., Hampartsoum Barsoumian

Electronic Theses and Dissertations

SA-4-1BBL is a recombinant costimulatory molecule that is active in its soluble form and has pleiotropic effects on the functions of innate, adaptive, and regulatory immune cells. We have previously shown that SA-4-1BBL makes CD4+ T conventional cells (Tconvs) resistant to suppression by CD4+CD25+Foxp3+ T regulatory cells (Tregs). The mechanistic basis of this observation is the subject of this study. We demonstrate that Tconvs, but not Tregs, are the direct targets of SA-4-1BBL-mediated evasion of Treg suppression without contribution from antigen presenting cells (APCs). SA-4-1BBL engagement with its receptor, 4-1BB, on Tconvs resulted in the production of high levels of …

Psychotherapy Dropout : The Influence Of Ethnic Identity And Stigma On Early Termination., Le'keldric Jawon Thomas

Electronic Theses and Dissertations

Although clients continue to drop out of psychotherapy, researchers have made few inroads into understanding the dropout phenomenon. Clinical studies have reported client dropout rates based on demographic factors (e.g., race, socioeconomic status, educational status). However, few studies have investigated the cultural correlates that may underlie these demographic factors and affect client termination. Furthermore, none have provided an empirically driven explanation as to why some clients drop out more often than others. In two studies, I explore dropout in two settings: a community mental health center and a university counseling center. Guided by current theory and research, I will examine …

Strategies Of Balancing: Regulation Of Posture As A Complex Phenomenon, Allison Leich Hilbun

Electronic Theses and Dissertations

The complexity of the interface between the muscular system and the nervous system is still elusive. We investigated how the neuromuscular system functions and how it is influenced by various perturbations. Postural stability was selected as the model system, because this system provides complex output, which could indicate underlying mechanisms and feedback loops of the neuromuscular system. We hypothesized that aging, physical pain, and mental and physical perturbations affect balancing strategy, and based on these observations, we constructed a model that simulates many aspects of the neuromuscular system. Our results show that aging changes the control strategy of balancing from …

An Investigation Into Formulation And Therapeutic Effectiveness Of Nanoparticle Drug Delivery For Select Pharmaceutical Agents, Dustin Cooper

Electronic Theses and Dissertations

Drug based nanoparticle (NP) formulations have gained considerable attention over the past decade for their use in various drug delivery systems. NPs have been shown to increase bioavailability, decrease side effects of highly toxic drugs, and prolong drug release. Furthermore, polymer based, biodegradable nanodelivery has become increasing popular in the field of NP formulation because of their high degree of compatibility and low rate of toxicity. Due to their popularity, commercially available polymers such as poly lactic acid (PLA), poly glycolic acid (PGA) and polylactic-co-glycolic acid (PLGA) are commonly used in the development and design of new nano based delivery …

Effects Of Lactobacillus Rhamnosus Milk Isolate On The Production Of Inflammatory Cytokines In Enterocytes, Beverly C. Ngeny

Electronic Theses and Dissertations

In the gastrointestinal tract, probiotics have been shown to promote host immunity and to regulate immune signaling pathways. This study used Caco-2 cell line to examine the effects of a Lactobacillus rhamnosus isolate from “amabere amaruranu” a Kenyan traditional cultured milk, on the production inflammatory cytokines in enterocytes. Live Lactobacillus rhamnosus (MRS6AN), its cytoplasmic fraction (CF), filtered spent broth (FSB) or heat inactivated FSB (HIB) were used as treatments on differentiated Caco-2 cell monolayer in transwells. Cytokine content in the cell lysates, apical and basolateral supernatants were determined using ELISA. Caco-2 cell lysate treatments showed significantly increased anti-inflammatory TGF-β (ng/ml) …

Computational Studies Of Spin Trapping Of Biologically Relevant Radicals By New Heteroaryl Nitrones, Eyram Asempa

Electronic Theses and Dissertations

Heteroaryl nitrone spin traps have been suggested to act as free radical scavengers. The geometry optimizations and the single-point energies of the spin trapping reactions of the heteroaryl nitrones, 5,5-dimethylpyrroline-N-oxide (DMPO) and α-phenyl-N-t-butylnitrone (PBN) have been computationally studied using ab initio (Hartree-Fock (HF) and second-order Møller-Plesset (MP2)) methods and Density Functional Theory (DFT) methods. The effects of new heteroaryl substituents on a parent nitrone spin trap have been examined at the HF and MP2 levels with the 6-31G*, and cc-pVnZ (n=D, T, Q) basis sets. The thermodynamics of the spin trapping at the C-site and O-site with •H, …

Investigation Of Novel Functions For Dna Damage Response And Repair Proteins In Escherichia Coli And Humans, Benjamin A. Hilton

Electronic Theses and Dissertations

Endogenous and exogenous agents that can damage DNA are a constant threat to genome stability in all living cells. In response, cells have evolved an array of mechanisms to repair DNA damage or to eliminate the cells damaged beyond repair. One of these mechanisms is nucleotide excision repair (NER) which is the major repair pathway responsible for removing a wide variety of bulky DNA lesions. Deficiency, or mutation, in one or several of the NER repair proteins is responsible for many diseases, including cancer. Prokaryotic NER involves only three proteins to recognize and incise a damaged site, while eukaryotic NER …

Comparison Of Anti-Pneumococcal Functions Of Native And Modified Forms Of C-Reactive Protein, Donald Neba Ngwa

Electronic Theses and Dissertations

The anti-pneumococcal function of native C-reactive protein (CRP) involves its binding to phosphocholine molecules present on Streptococcus pneumoniae and subsequent activation of the complement system. However, when pneumococci recruit complement inhibitory protein factor H on their surface, they escape complement attack. Non-native forms of CRP have been shown to bind immobilized factor H. Accordingly, we hypothesized that modified CRP would bind to factor H on pneumococci, masking its complement inhibitory activity, allowing native CRP to exert its anti-pneumococcal function. As reported previously, native CRP protected mice from lethal pneumococcal infection when injected 30 minutes before infection but not when injected …

Teacher And Student Perceptions On High School Science Flipped Classrooms: Educational Breakthrough Or Media Hype?, Rebecca C. Hunley

Electronic Theses and Dissertations

For years educators have struggled to ensure students meet the rigors of state mandated tests. Challenges that often impede student success are student absences, school closings due to weather, and remediation for students who need additional help while advanced students can move ahead. Many educators, especially secondary math and science teachers, have responded to these issues by implementing a teaching strategy called the flipped classroom where students view lectures, power points, or podcasts outside of school and class time shifts to allow opportunities for collaborative learning.

The purpose of this research was to evaluate teacher and student perceptions of high …

Spirituality And Psychological Well-Being Among Als Caregivers: Hope And Perceived Stress As Mediators, Bridget R. Jeter

Electronic Theses and Dissertations

The empirical study of the salutary relationship between spirituality/religiousness and psychological well-being is burgeoning. However, mechanisms of this association have received less empirical attention. Theory suggests that spirituality/religiousness may lead to positive psychological characteristics such as hope, which may function as a means of coping in the context of a significant stressor or stressful situation. The perceived burden and stress associated with caring for individuals with chronic illnesses such as ALS is significant, and caregivers may be at risk for increased symptoms of depression, symptoms of anxiety, somatic symptoms, and other deleterious psychological well-being related outcomes. Within the context of …

Effects Of Acclimation On Temperature Tolerance And Oxidative Damage In Daphnia Magna, Kailea J. Holbrook Ms.

Electronic Theses and Dissertations

Freshwater zooplankton crustacean Daphnia frequently face strong temperature fluctuations in its natural environment, which necessitates adaptive plastic responses. This study focuses on changes in lipid peroxidation and total oxidative capacity in Daphnia tissues in response to long-term and short-term temperature changes.

Long-term acclimation to 28ºC helped Daphnia survive longer at lethally high temperatures. This difference, however, was not accompanied by changes in lipid peroxidation, indicating that it isn’t a good measure of damage or predictor of temperature tolerance.

On the other hand, total oxidation capacity was lower 28ºC- than in 18ºC-acclimated Daphnia, suggesting that acclimation resulted in higher amounts …

The Apoptotic And Inhibitory Effects Of Phylloquinone In The U937 Cell Line, Tesha E. Blair

Electronic Theses and Dissertations

Phylloquinone is a natural analog of vitamin K that has been shown to both inhibit cancer cell growth and induce apoptosis in several cancer cell lines. This study examined these effects in a non-Hodgkin lymphoma cell line, known as U937. Cell growth inhibition and apoptosis were assessed through the quantification of cell density and area, following treatment with several concentrations of phylloquinone. In addition, apoptosis was detected and quantified using immunofluorescent markers of apoptosis (i.e. annexin V, APO-BrdU). Treatment with phylloquinone resulted in reduced overall cell density, increased overall cell area, and an increased frequency of apoptosis in U937 cells. …

Comparison Of In Vivo Simulation Training Compared To Video Simulation Training For Identifying Clinical Markers Of Distress When Feeding Preterm Infants, Emily M. Wagner

Electronic Theses and Dissertations

Preterm infants have multiple health complications due to their underdeveloped neurological systems. Bottle-feeding difficulties are one complication that leads to pulmonary illness secondary to aspiration. Preterm infants exhibit clinical markers when experiencing distress during bottle-feeding. Training caregivers to identify clinical markers reduces the risk for aspiration. Simulation training provides a safe learning environment without harming patients. Twenty-two speech-language pathology and pre-requisite students divided into two simulation groups, video-simulation (N=12) and in-vivo simulation (N=10), were trained to document clinical markers of distress exhibited by preterm infants and make clinical judgments about bottle-feeding. Students rated their levels of anxiety during simulation training. …

Regulation Of Acute And Chronic Immune Responses By Β-Arrestin2, Hui Yan

Electronic Theses and Dissertations

β-arrestin2, previously recognized as a facilitator for G-protein associated 7 TMR desensitization/ internalization, has now been appreciated as an independent signal transducer that regulates multiple cellular responses including inflammation. Cecal ligation and puncture procedure (CLP) induced septic shock is an acute inflammatory response characterized by uncontrolled systemic inflammation. Myocardial ischemia/reperfusion is a chronic sterilize inflammation that requires the reaction of macrophages, fibroblasts and cardiac stem cells for regeneration and remodeling of the infarcted myocardium. Restrained chronic stress is an immune suppression model in which the inactivation of macrophages may be involved. Here we showed β-arrestin2 overexpression inhibited CLP-induced heart dysfunction …

An Examination Of The Community School Model In An Urban School Setting, Tanna H. Nicely

Electronic Theses and Dissertations

The topic of educating today’s youth has become an increasing multi-faceted task with rigorous accountability metrics handed down from all of the different branches of government. Schools are faced with providing more than just instructing the three R’s; they are taxed with educating the whole child.

This qualitative study explored the community schools model in an urban elementary school. Specifically, the study attempted to understand the perceived impact this model has on community members, parents, and administrators at one particular elementary school. Data were collected through a series of open-ended interviews and coded for inductive analysis. There were four emerging …

Assessing Adult Tobacco Smoking Cessation In Low-And-Middle Income Countries: Analysis Of The Global Adult Tobacco Survey Data, 2009 – 2012, Daniel Owusu

Electronic Theses and Dissertations

Smoking cessation can reduce health risk and prevent millions of tobacco-related deaths. However, cessation rates are low in low-and-middle income countries (LMICs), with only a small proportion of smokers intending to quit. Given the paucity of literature to support tobacco cessation programs in LMICs, this study aimed to: 1) identify factors associated with intention to quit smoking, 2) assess the relationship between health care provider quit advice/tobacco screening and utilization of cessation assistance, and 3) examine the relationship between home smoking rule and smoking intensity across three stages of smoking cessation (precontemplation, contemplation and preparation) in LMICs. Data were obtained …

Middle School And Community Rockford, Illinios, Katera B. Smith

Electronic Theses and Dissertations

This study of 99 middle school students in an urban area examined the relationship between community factors and student outcomes. The community factors that were examined were school violence based on if a student was a victim or witness and also if the student was an offender of school violence, violence and substance use exposure based on student’s home location, and socioeconomic status were also examined. Student outcomes were examined based on academic testing (Partnership for Assessment of Readiness of College and Careers or PARCC), grade point average (GPA), and school suspension (both Out-of-School Suspension or OSS and in-school-suspension/Alternative Learning …

A Case Study: The Factors Associated With Student Homelessness, Brittani Hudspeth

Electronic Theses and Dissertations

The purpose of this case study is to identify the factors associated with student homelessness. There are currently more than 1.5 million children who are living in a homeless family (National Center for Family Homelessness, 2009), and a percentage of that number are homeless students living on their own. This study engages existing literature to identify the causes of student homelessness and the impacts it has on the lives of those students. The study was conducted by using quantitative research through a Mood and Feelings Questionnaire (MFQ) and qualitative research by utilizing a psychosocial assessment called the home, education and …

The Relationship Between Resilience And Sleep Quality, Tyler S. Mccuistion

Electronic Theses and Dissertations

Complaints about sleep quality are common and some epidemiological surveys indicate that 15-35% of adults complain of frequent sleep disturbances. Impaired sleep is also a central feature in a number of mental health conditions such as depression and anxiety. This study was aimed at examining the relationship between sleep quality and resilience (the ability to cope and deal with stress). The hypothesis was that the two variables would be related; as resilience increased, it was predicted that sleep quality would also increase. Individuals (N = 167) were given the opportunity to complete a number of brief, self-report inventories assessing …

An Analysis Of Elementary Interventions On Academic And Behavioral Performance, Sarah Mclean

Electronic Theses and Dissertations

The Communities In Schools (CIS) model promotes individualized one-on-one interventions for at-risk students assessed for needs in the areas of academics, behavior, and/or attendance. While previous research has linked the CIS program to higher graduation rates and lower dropout rates in secondary grades, little research has been done to examine the impact of the CIS program on elementary students. Using data from student records of at-risk elementary students receiving CIS services and those at-risk elementary students on a campus without the CIS program, this study examined the effect of the CIS services on student absences, behavior incidents, citizenship, and academic …

Intertextual Discourse And The Problem Of God: The Intersection Of The Speeches Of Job And Deuteronomy, James Kipp Swinney

Electronic Theses and Dissertations

Common understandings of the books of Job and Deuteronomy cast them as contradictory documents. Some scholarship concurs with this view. Despite this understanding, scholarship has not thoroughly investigated the relationship of these two texts. The book of Job carries allusion and references to much literature in the Hebrew Bible and the ancient Near East. In this thesis, I argue that the speeches of the character Job create a constructive dialogue with the book of Deuteronomy. While the views of the books are not identical, I argue that the speeches of Job largely evidence affirmation of Deuteronomy rather than derision or …

Hunting Down Pigs, Anna-Lisa Astudillo

Electronic Theses and Dissertations

Hunting Down Pigs is a hybrid collection of personal essays, ranging from lyrical to braided, which more often than not defy labeling. The essays explore themes of loss, faith, and self-reliance. Growing up Mormon, with all its strictures, and losing her dad at a young age, made faith an issue that the narrator grappled with continuously throughout her life. The narrator questions the validity and purpose of religion in essays like "Possibilities" and "Going to Church." Specifically, the narrator explores the doctrine of the Mormon church and the effects of such a strict upbringing. When divine intervention fails, the narrator …

Emergency Room Utilization Disparities Among Older Adults Treated By Rural Health Clinics, Matt Bagwell

Electronic Theses and Dissertations

Examining the persistence of disparities over time is an important obligation in terms of rectifying, maintaining, and improving community health and social well-being for all. This study analyzed the individual factors of (a) race/ ethnicity and (b) dual eligibility, as a proxy measure of socioeconomic status, as well as the environmental factor of (c) place of residence, and the organizational factor of (d) Rural Health Clinic (RHC) type on emergency room (ER) utilization of older adult Medicare patients treated by RHCs within the Department of Health and Human Services' (DHHS) Region 4. A prospective, multi-level, longitudinal design was employed to …

Tobacco Prevention And Cessation Policies And Youth Tobacco Use In Florida Public Schools, Amanda Terry

Electronic Theses and Dissertations

Tobacco use is the leading cause of preventable disease and premature death in the United States. In 2014, an estimated 16.8% of adults were current cigarette smokers, and 9.2% of high school students smoked cigarettes. Nearly 90% of smokers developed their habit as teenagers, and students' tobacco use in high school influences their behaviors later in adulthood. Smoking behaviors appear to be inseparable from the social environment, physical environment, small social groups, and cognitive and affective processes. Preventive strategies, such as advertising bans, clean indoor air laws, education programs, increased taxes, labeling limitations, mass-media campaigns, and youth access regulations, have …

Cardiac Autonomic Control In Patients With Metabolic Syndrome, Jonathan Mitchell

Electronic Theses and Dissertations

Metabolic syndrome (MetS) encompasses metabolic abnormalities that substantially increase risk for chronic illnesses. MetS and stress are closely related; the pathophysiology of MetS involves dysregulated stress response in both the physiological and psychological domains. In an effort to further clarify the relationship between metabolic abnormalities and autonomic dysregulation, we used ambulatory impedance cardiography to examine indicators of cardiac autonomic control (CAC) in a sample of 50 adult primary care patients with and without MetS. Indices of sympathetic and parasympathetic influences on cardiovascular functioning were assessed in the context of psychological stressors and compared across experimental groups and examined in relation …

Neuroprotection Comparison Of Different Nutraceutical Compounds Against Mechanistically Distinct Cell Death Inducing Agents, Faten I. Taram

Electronic Theses and Dissertations

Neurodegenerative diseases like Alzheimer's disease (AD), Parkinson's disease (PD), and amyotrophic lateral sclerosis (ALS), include the progressive loss of structure and function of neurons leading to neuronal death. All of these diseases are fatal, as there is no cure for them. The causes of these diseases are unknown; however, there are many proposed mechanisms that lead to neurodegenerative diseases. Oxidative stress is the leading cause of cell death in neurodegenerative diseases, in addition to other mechanisms including endoplasmic reticulum stress, proteasome inhibition, nitrosative stress, inflammation and excitotoxicity. More understanding of the death mechanisms at work in neurodegeneration is necessary to …

Science As A Second Language: Analysis Of Emergent Bilingual Performance And The Impact Of English Language Proficiency And First Language Characteristics On The Colorado Measures Of Academic Success For Science, Joanna Kristine Bruno

Electronic Theses and Dissertations

In an age when communication is highly important and states across the nation, including Colorado, have adopted Common Core State Standards, the need for academic language is even more important than ever. The language of science has been compared to a second language in that it uses specific discourse patterns, semantic rules, and a very specific vocabulary. There is a need for educators to better understand how language impacts academic achievement, specifically concerning Emergent Bilinguals (EBs). Research has identified the need to study the role language plays in content assessments and the impact they have on EBs performance (Abedi, 2008b; …

The Role Of Integrated Health Care In Reducing Stigma Around Seeking Psychological Help Among International Students, Brinda Prabhakar-Gippert

Electronic Theses and Dissertations

The intention of this study was to better understand the international student experience. The present study examined the relationships between acculturative stress, stigma, and behavioral healthcare, using Berry's Theory of Acculturation. A sample (N = 135) of international students completed measures of acculturative stress, perceived social support, self-stigma for seeking help, and perceived stigma by others for seeking help . Results of a hierarchical regression analysis indicated that acculturative stress is a statistically significant predictor of perceived stigma by others for seeking help, and that acculturative stress is not a statistically significant predictor of self-stigma for seeking help. Moderation …

"Discursion And Excursion:" Poetry Of Bodies, Place, And Landscape In The Ecocritical Movement, Haley N. Littleton

Electronic Theses and Dissertations

My thesis project focuses on the current literary field of Ecocriticism, its historical transmutations, and the correlation of the pastoral genre, as one begins to understand current human understandings of "nature." By applying a deeper understanding of the Deep Ecology movement, along with shifting understandings of the human and the non-human, specifically in our usage and attention to landscape and wilderness, I hope to explore the role that the aesthetic, and the function of the poem, can play a crucial role in the environmental movement. By building a foundational understanding of our cultural context and critical theories of Environmental criticism, …