Digital Commons Network^™

Could Alexa Increase Your Social Worth?, Peter Tripp

Electronic Theses and Dissertations

People have historically used personal introductions to build social capital, which is the foundation of career networking and is perhaps the most effective way to advance a career (Lin, 2001). With societal changes, such as the pandemic (Venkatesh & Edirappuli, 2020), and the increasing capabilities of Artificial Intelligence (AI), new approaches may emerge that impact societal relationships. Social capital theory highlights the need for reciprocal agreements to establish the trust between parties (Gouldner, 1960). My theoretical prediction and focus of this research include two principles: The impact of reciprocity in evaluating trust of the source of the introduction and the …

An Intersectional Perspective On The Role Of Workplace Policy Among Employed Female Caregivers During The Coronavirus Pandemic, Jessica King Mclaughlin

Electronic Theses and Dissertations

Providing care for an older adult while working can be challenging, often leading to caregiver burden. The socioenvironmental context of the coronavirus pandemic creates additional complications for working caregivers. Women, who are the majority of informal caregivers, face unique stressors in the workplace (McKinsey & Company, 2019; Carnevale et al., 2018). Prior to and during the coronavirus pandemic, workplace policies have offered the potential of support, yet more information is needed on how working female informal caregivers of older adults of diverse identities receive, interpret, and experience these policies amidst the context of the pandemic. This study uses a phenomenological …

Improving Quantification Of Mitral Regurgitation Through Computational Fluid Dynamics And Ex Vivo Testing, Alexandra Flowers

Electronic Theses and Dissertations

Mitral regurgitation (MR) is a prominent cardiac disease affecting more than two million people in the United States alone. In order for patients to receive proper therapy, regurgitant volume must first be quantified. As there are an array of methods to do so, the proximal isovelocity surface area (PISA) method continues to be the most accurate and clinically used method. However, there are some difficulties obtaining the necessary measurements need for this when performing transthoracic echocardiography. This study aims to evaluate and present techniques that may be used to more accurately quantify regurgitation through ex vivo testing and computational fluid …

Perceptions Of Parental Care And Overprotection In Childhood: Influences On The Neurobiological Adaptation To Motherhood, Leah Grande

Electronic Theses and Dissertations

Recalled memories of caregiving in childhood are especially salient during the postpartum period and inform mothers’ conceptualization of her new parenting role. Positive perceptions of care received from one’s parents are related to improved maternal-infant bonding and positive parenting behaviors, whereas negative perceptions of care convey risk for maladaptive parenting. Few studies have investigated neural and biological mechanisms contributing to observed associations between childhood care and the adaptation to motherhood. The following studies address this gap by examining how perceptions of childhood parental care and overprotection are related to maternal behavior, oxytocin levels, and neural response. Methods: Perceived childhood maternal …

Assessing The Relationship Between White Privilege, White Fragility, And Masculine Gender Identity And Stressors In The Workplace, Anna Edelman

Electronic Theses and Dissertations

The current study examined how White privilege information avoidance and White fragility are related to aspects of traditional masculinity. Informed by Critical Race Theory and Critical Whiteness Studies, this study examined the link between traditional masculine norms, masculine gender identity stress, and White privilege reactions. A sample of White, working men were recruited both through snowball sampling and Amazon’s Mechanical Turk. Participants were first assessed on a variety of masculinity variables and then were randomly assigned to view one of two video vignettes. After viewing this video, their affective responses, White privilege information avoidance, and White fragility were assessed through …

Classification Of Electropherograms Using Machine Learning For Parkinson’S Disease, Soroush Dehghan

Electronic Theses and Dissertations

Parkinson’s disease (PD) is a neurodegenerative movement disorder that progresses gradually over time. The onset of symptoms in people who are suffering from PD can vary from case to case, and it depends on the progression of the disease in each patient. The PD symptoms gradually develop and exacerbate the patient’s movements throughout time. An early diagnosis of PD could improve the outcomes of treatments and could potentially delay the progression of this disorder and that makes discovering a new diagnostic method valuable. In this study, I investigate the feasibility of using a machine learning (ML) approach to classify PD …

Inhibition Of De Novo And The Prion-Like Spread Of Amyloidogenesis Using In Vitro And In Vivo Disease Models, Johnson Anazoba Joseph

Electronic Theses and Dissertations

The aberrant fibrous, extracellular, and intracellular proteinaceous deposits in cells, organs and tissues are referred to as amyloids. These deposits are dominated by β-sheet structures that have been implicated in several neurodegenerative diseases and cancer. In this work, the types of amyloidosis studied include Parkinson’s disease (PD) using UA196 and NL5901 strains of Caenorhabditis elegans (C. elegans), Alzheimer’s disease (AD) using GMC101 strain of C. elegans, and cancer-associated mutant p53 aggregation in MIA PaCa-2 mutant cells. Several molecules including SK-129, NS132, NS163, bexarotene, a polyphenol (-)-epi-gallocatechine gallate (EGCG), ADH40, RD148, and RD242 were screened in vitro and in …

Directly Polymerizable Co Releasing Molecules, Jackson Snow

Electronic Theses and Dissertations

Despite the commonly held consensus that carbon monoxide (CO) is toxic, it has been shown to be an essential signaling molecule in the human neuronal system and has been noted to have anti-inflammatory properties, act as a vasodilator, have anti-proliferative impacts on tumors, and many other beneficial effects. The current limitation to using CO as a therapeutic molecule is delivering the proper dosages using CO releasing molecules (CORMs) without exhibiting toxicity. The first chapter of this thesis will review the biological significance of CO in biological systems, the limitations of existing CORMs, and the properties of diphenylcyclopropenone (DPCP) that make …

Lipophilic Probes For Cellular Ethylene Detection, Morgan R. Brown

Electronic Theses and Dissertations

The structure of ethylene is simple, yet its biological effects are significant. When considering its role in biology it is almost exclusively regarded as a plant hormone. Research on ethylene from plants was progressed by several advancements in analytical instrumentation, from its discovery to elucidation of its signaling pathway. There is currently limited understanding of ethylene’s role in mammals, but evidence suggests that it may be a biomarker for oxidative stress! Additional tools and technology are crucial to study this surprising and important signaling role in mammals. Our group has developed molecular ethylene probes as a strategy to detect ethylene …

Music Theory Pedagogy For The Violin: Cognitive Philosophy And Three Model Curricula, Morganne J. Mcintyre

Electronic Theses and Dissertations

Violin playing promotes a connection between mind and body that allows the performer to internalize, or embody, tactile features of the instrument, such as the distance between strings, the feeling of the fingertips on the fingerboard, the interval size between notes, and many other aspects. This thesis designs a pedagogy that employs the violin’s physical attributes to provide the beginning through advanced player with a deeper understanding of music theory. The thesis suggests pairing of physical learning and musical theory at each stage of a violinist’s musical education. Chapter 1 surveys embodied cognition and cognitive artifacts. Chapter 2 applies these …

Puerto Ricans And Asthma: Looking Through The Lens Of Historical Trauma, Lisa Colón

Electronic Theses and Dissertations

This study utilized an explorative phenomenological qualitative design to begin understanding the many ways Puerto Ricans experience asthma. Further is sought to understand the asthma experience broadly and within the context of the hurricanes that devastated Puerto Rico in 2017 including the governments’ responses to that devastation. Another core goal of this study was the conceptual and empirical application of the theoretical framework of historical trauma to Puerto Ricans. I conducted 12 semi structured interviews with collaborators who expressed a range of asthma experiences. My collaborators represented a mixture of those who lived through the hurricanes in Puerto Rico and …

Where Virtual Well-Being Becomes Reality, Colleen M. Reilly

Electronic Theses and Dissertations

Strategies to mitigate the spread of COVID-19, specifically quarantine and social distancing protocols, have exposed a troubling paradox: mandated isolation meant to save lives has inadvertently contributed to a decline in America’s well-being. Prolonged isolation due to more remote work and decentralized workplaces has been associated with widespread loneliness and diminished physical and mental health, with effects compounded by limited face-to-face access to social support systems. While remote communication technologies (e.g., video chat) can connect individuals with colleagues and social networks, remote technologies might have limited effectiveness in business and social contexts. This study uses Roger’s Diffusion of Innovation Theory …

Emotion Dysregulation And Intimate Partner Aggression During Pregnancy: Leveraging Both Partners’ Experiences With Dyadic Data, Victoria M. Atzl

Electronic Theses and Dissertations

Intimate partner aggression (IPA) during pregnancy is a significant public health problem that has negative consequences for maternal and fetal health. This study examined emotion dysregulation as a potential predictor of IPA during pregnancy from a dyadic perspective. Participants were 113 couples expecting a baby and included 113 mothers (MOBs; Mage = 27.50 years, SDage = 5.53, rangeage = 19-40; 38.1% White, 24.8% Latinx, 15.9% African American, 14.2% biracial/multiracial, 3.5% Asian American/Pacific Islander, 2.7% Native American and .8% other) and 113 fathers (FOBs; Mage = 29.83 years, SDage = 7.61, rangeage = 18-55; 38.1% White, 22.1% African American, 20.4% Latinx, …

Mis-Specification Of Functional Forms In Growth Mixture Modeling: A Monte Carlo Simulation, Richa Ghevarghese

Electronic Theses and Dissertations

Growth mixture modeling (GMM) is a methodological tool used to represent heterogeneity in longitudinal datasets through the identification of unobserved subgroups following qualitatively and quantitatively distinct trajectories in a population. These growth trajectories or functional forms are informed by the underlying developmental theory, are distinct to each subgroup, and form the core assumptions of the model. Therefore, the accuracy of the assumed functional forms of growth strongly influences substantive research and theories of growth. While there is evidence of mis-specified functional forms of growth in GMM literature, the weight of this violation has been largely overlooked. Current solutions to circumvent …

Measurements Of Atmospheric Radicals, Heather L. Runberg

Electronic Theses and Dissertations

Atmospheric particulate matter (PM) is a global health concern. PM_2.5 is formed primarily through combustion processes such as automobile use and industrial activity. Natural sources of PM_2.5 result from events like volcanos and wildfires. Upon inhalation, PM_2.5 is small enough to travel deep into the lungs where it can form reactive oxygen species (ROS), such as hydroxyl radical (OH), causing oxidative damage to pulmonary tissues. PM_2.5 has been linked to cardiopulmonary diseases such as asthma, chronic obstructive pulmonary disease (COPD), and high blood pressure.

PM_2.5 is small enough to remain aloft and travel many hundreds …

Esipt-Enabled Alkyne Migration Provides Rapid Access To Benzoxazinones, Andrés G. Muñoz

Electronic Theses and Dissertations

Benozoxazinones have long been of interest to agrochemical scientists and medicinal chemists because of their widespread biological activity. These scaffolds are also of interest to synthetic chemists, who recognize the utility of benzoxazinones for accessing functionalized heterocycles. The use of efavirenz, a benzoxazinone-based reverse transcriptase inhibitor used in the treatment of HIV-1, has brought increased attention to this privileged pharmacophore. While there exist numerous strategies for synthesizing benzoxazinones, methods that do not require the use of acutely toxic and environmentally hazardous reagents are lacking. Consequently, there is a need to develop new methods for constructing this valuable scaffold. Herein, we …

The Intersection Of Traumatic Brain Injury And Homelessness, Stephanie A. Chassman

Electronic Theses and Dissertations

The rates of TBI are significantly higher among individuals experiencing homelessness compared to the general population. Up to half of individuals experiencing homelessness may have a TBI. Accurate prevalence rates of TBI among individuals experiencing homelessness are difficult to obtain due to different methods of sampling participants and differing definitions of TBI; therefore, estimates may be underrepresented. Despite past research that has examined the relationship between TBI and homelessness, there are specific gaps in knowledge such as correlates and risk factors of TBI among individuals experiencing homelessness. This three-manuscript dissertation attempts to address these gaps in knowledge.

The first manuscript …

Developing, Refining, And Testing The Intersectional Model Of Service Use: A Transgender And Nonbinary-Specific Model Of Healthcare Access, Jarrod Call

Electronic Theses and Dissertations

Transgender and nonbinary (TNB) people are more likely to experience negative health outcomes than cisgender (i.e., not TNB) people, but less likely to access healthcare services due to the systemic forces of transphobia and cisgenderism. Despite this, there are few theoretical models of healthcare access specifically designed for TNB people. This three-paper dissertation addresses this gap by developing, refining, and testing the Intersectional Model of Service Use (IMSU), a population-specific framework for researching TNB healthcare access. Manuscript one describes how the initial IMSU was developed from an integrative review of currently available TNB healthcare access literature. This initial IMSU was …

Extracellular Vesicles And Lipid Flippase Regulators In C. Elegans, Lauren Pitts

Electronic Theses and Dissertations

Extracellular vesicles (EVs) are membrane derived organelles released by all cell types and carry a vast array of cargos that can influence communication, development, and disease. One type of EV, known as microvesicles, form by budding directly from the plasma membrane in a process known as ectocytosis, however the mechanisms that govern this process are poorly understood. In C. elegans, the P4-ATPase, TAT-5, along with its activator, PAD-1, inhibit EV release from the plasma membrane by inhibiting phosphatidylethanolamine (PE) exposure on the outer leaflet of the plasma membrane. We identified 3 key domains of PAD-1 that are required to inhibit …

Structural And Hemodynamic Analysis Of Transcatheter Aortic Valves, Dong Qiu

Electronic Theses and Dissertations

The transcatheter aortic valve replacement (TAVR) procedure has become a well-established procedure for high, intermediate-risk, and low-risk patients. However, there is limited clinical data on the TAV's long-term durability, unlike SAV devices. Computational simulations can be an alternative way to evaluate the TAV devices. This dissertation aims to conduct structural and hemodynamic analyses on the TAV devices under different conditions using computational simulation approaches.

Initially, the impact of the bicuspid aortic valve on the TAV devices was evaluated. The result indicated that the CoreValve-like supra-annular self-expandable device was likely to have increased stress and strain on the leaflet when it …

Outdoor Early Intervention Services: Current Practices And Future Directions, Tiffany Lee

Electronic Theses and Dissertations

Outdoor play is a crucial in supporting child development, resiliency, social skills, creative thinking, adaptability, family growth, and family engagement. Unfortunately, children are spending less time outside because of technology, parent fears, and other factors. Parents who have a child with a disability have even more challenges when it comes to playing outside. Thus, children with disabilities are spending even less time in outdoor environments. Early Intervention (EI) is a program that is designed for infants and toddlers between the ages of zero to three that have developmental delays and/or disabilities. EI uses a family-center approach in natural environments to …

Evaluating The Impact Of Individual And Couple Relationship Education On Postpartum Depression, Maggie O’Reilly Treter

Electronic Theses and Dissertations

This dissertation evaluated the impact of relationship education on postpartum depression using data from two randomized controlled trials of relationship education for individuals and couples who were pregnant or recently had a baby. Paper 1 focused on a well-established relationship education program for low-income couples in Oklahoma City, Family Expectations. Key findings from Paper 1 demonstrated that being randomized to Family Expectations was associated with lower odds of experiencing depression in the first 12 months after having a baby among both mothers and fathers, though this effect was only marginally significant, and that the program had the strongest impact among …

Pulmonary Valve Replacement, Mina Shafiei

Electronic Theses and Dissertations

Currently, transcatheter pulmonary valve replacement (TPVR) is a well-established alternative for surgical pulmonary valve replacement (SPVR) to treat pulmonary valve disorders in patients with prior congenital heart surgery. Edwards Sapien 3 valve is a bioprosthesis originally designed for the aortic position but has been used off-label in native right ventricular outflow tract (RVOT). It is currently under clinical trial to get food and drug administration (FDA) approval.

This study is a comparison of the performance of Sapien 3 with surgical bioprosthetics. The in vitro tests result showed Sapien 3 experiences less degree of opening and effective orifice area in pulmonic …

Environmental Gradients Impact Key Leaf Traits In Riparian Trees, Amanda Malone

Electronic Theses and Dissertations

Specific leaf area (SLA) reflects a plant’s carbon investment per area and relates to generalized leaf economics spectrum growth strategies (LES). To fill gaps of knowledge about intraspecific SLA variation and why it is often inconsistent with the LES, we studied the response of two riparian tree species along the urban-rural gradient in Northeastern Colorado: an invasive, nitrogen-fixer with broad tolerances and a nitrogen-limited and shade-intolerant native. Despite these differences, the two species responded similarly, apart from the response to the urban-rural gradient, in which lower nitrogen in rural areas was associated with a more conservative strategy in the native …

Well-Being Development: Parents’ Perceptions Of Gifted Adolescents, Barbara Moncure Washington

Electronic Theses and Dissertations

The purpose of this study was to examine parents’ perceptions of well-being development in their gifted adolescents. This was a qualitative study that used Narrative Inquiry as a research approach. Cloninger’s (1993) Psychobiological Model of Temperament and Character the (TCI) and Clandinin and Connelley’s (2000) Three-Dimensional Narrative Inquiry Space were utilized to address the research questions: What are parents’ perceptions of temperament in their gifted adolescent? What are parents’ perceptions of character in their gifted adolescent? What are the parents’ perceptions of well-being development? Dabrowski’s Theory of Positive Disintegration (TPD) provided an analysis lens for the study.

The framework for …

The Pathophysiological Mechanisms Of Alzheimer's Disease; Investigating Therapeutic Interventions For Disease Onset, Alexandra A. Sandberg

Electronic Theses and Dissertations

Alzheimer’s Disease is a multifarious disease that progressively affects more people as both the proportion of older adults in the population and life expectancy increase in both the United States and worldwide. This devastating disease is a result of rampant neuronal loss in the memory centers of the brain that robs the independence of those who are diagnosed and places a heavy burden on those who care for them. Traditionally speaking, research has focused on the hallmark pathology of amyloid plaques, targeting them to try and prevent disease onset. However, countless failures in clinical trials aimed at this said pathology …

Dynamics And Turnover Of Lipid And Protein Domains In Cells And Supported Bilayers, Alan Weisgerber

Electronic Theses and Dissertations

Protein and lipid clustering is an important mechanism for cell processes such as exo- and endo-cytosis and creating functional signaling complexes. It has been seen that both lipids and proteins are involved with the formation of cluster domains on cell membranes, yet little is known about the interplay between the two. In this work I began with visualizing lipid sorting to artificially induced curvature in supported lipid bilayers, with lipid tails affecting the sorting differently to curvature. These results demonstrate that lipids sort to curvature on curved, supported lipid bilayers. The sorting depends on the number of lipids in the …

Antioxidant Biomarkers And Nutraceutical Therapeutics In Neurodegeneration And Neurotrauma, Lilia A. Koza

Electronic Theses and Dissertations

Mild traumatic brain injury (mTBI), yielding a Glascow Coma Scale of 13-15, is the most commonly occurring severity of TBI. Pathology from mTBI consists of blood brain barrier disruption, neuroinflammation, oxidative stress, excitotoxicity, mitochondrial dysfunction, protein aggregation, axonal degeneration, and resulting neuronal death. These processes deplete the body’s endogenous antioxidant system. We report a retrospective analysis of antioxidant blood biomarkers in patients with a history of mTBI from a local sports medicine clinic, Resilience Code. We found persistent sex-specific antioxidant depletions in mTBI patients associated with worsened symptomology.

Certain populations, such as athletes, are at high risk for repetitive mTBI …

Morphological Variation And Community Science In Orthoptera, Amy Byerly

Electronic Theses and Dissertations

Patterns of morphological divergence across species’ ranges provide insight into local adaptation and speciation. Here, we compare phenotypic divergence among 4,221 crickets from 337 populations of two related species of field cricket, Gryllus firmus and G. pennsylvanicus and their hybrids. We find that these species differ across their geographic range in key morphological traits, such as body size and ovipositor length, and we directly compare phenotype with genotype for a subset of crickets demonstrating nuclear genetic introgression, phenotypic intermediacy of hybrids, and essentially unidirectional mitochondrial introgression. We discuss how these morphological traits relate to life history differences between the species. …

The Genuine Alacrity Of Things, Evelyn Hampton

Electronic Theses and Dissertations

“The Genuine Alacrity of Things” is a short story collection. Themes include personal identity, the Anthropocene, grief, family, and relationships. The story collection is introduced by a critical introduction.