Digital Commons Network^™

Development Of A Novel Psychological Screening Tool For Young Children In Educational And Childcare Settings, Diana Tinsley

Electronic Theses and Dissertations

Young children experience psychological difficulties at comparable rates to school-aged children (Egger & Angold, 2006; Bufferd et al., 2011; Fuchs et al., 2013), yet few screening tools are available for this age range. Childcare and preschool settings present a unique opportunity to increase early screening efforts, particularly in terms of observing children among their peers. The current study presents initial steps toward the development of a new psychological screening tool for young children ages 1.5 – 5 years in childcare and educational settings. The aim of the study was to develop a brief and broad psychological screening tool that can …

Formulation Development And Targeted Delivery For Bcs Ii Drugs Using Hot Melt Extrusion Technology, Ahmed Almotairy

Electronic Theses and Dissertations

Hot-melt extrusion (HME) is one of the approaches to formulate an amorphous solid dispersion (ASD) and has gained popularity within the pharmaceutical industry over the past three decades. Additionally, HME has the ability to produce several versatile formulations and its ability to tailor processing materials through modifications in the screw design and mixing and shearing forces or by controlling the material feed rate; additionally, HME allows processing at multiple temperatures and screw speeds. HME has advantages over traditional pharmaceutical processing techniques, including its ability for continuous operation and ability to implement quality by design (QbD) and process analytical technology (PAT) …

Solubility Enhancement Of Atorvastatin Calcium Using Cyclodextrin, Karthik Abburi

Electronic Theses and Dissertations

The present study is intended to increase the solubility and dissolution rate of Atorvastatin calcium (ATN Ca) by formulating the drug- hydroxy-propyl-beta cyclodextrin (HPBCD) complexes using solvent-assisted extrusion (SAE) using a twin-screw extruder. Various studies on ATN Ca saturation solubility in water and other pH mediums revealed a pH-dependent solubility with a difference. Thus, the saturation solubility for ATN Ca and Solvent Assisted Extruded complex was conducted in water and different pH mediums in this study. Phase solubility studies between ATN Ca and CDs revealed an AL-type solubility profile exhibiting a linear increase with HPBCD. Drug-HPBCD complexes were made using …

Computational Investigation Of The Structures And Vibrational Spectra Of Isolated And Hydrated Ions, Kayleigh R. Barlow

Electronic Theses and Dissertations

High-accuracy electronic structure theory methods are important in the field of chemistry for probing molecular properties of chemically relevant systems that are often difficult to obtain experimentally. This work focuses primarily on using robust computational techniques to characterize not only small triatomic anions but also anion-water clusters in addition to investigating their vibrational frequencies near the complete basis set (CBS) limit. The MP2 and CCSD(T) ab initio methods are used with second-order vibrational perturbation theory (VPT2) and vibrational configuration interaction (VCI) theory in this work to compute the fundamental vibrational frequencies of small anions. Due it being arduous to experimental …

Formulation Development And Characterization Of Dual Drug Loaded Hot-Melt Extruded Inserts For Better Ocular Therapeutic Outcomes: Sulfacetamide/Prednisolone, Indrajeet Karnik

Electronic Theses and Dissertations

The objective of this investigation was to formulate, characterize, and evaluate a bioadhesive, hot-melt extruded (HME), immediate- and extended-release ophthalmic inserts containing a fixed-dose combination of Prednisolone Sodium Phosphate (PSP) and Sulfacetamide Sodium (SA) to improve the treatment outcomes of multiple ocular bacterial infections. The HME inserts were prepared using FDA-authorized biocompatible polymers including Polyox WSR N10 LEO NF (polyethylene oxide; PEO), Klucel™ HF (hydroxypropyl cellulose; HPC-HF), and Ethocel™ (Ethylcellulose; EC). The inserts were then assessed for physicochemical characteristics, weight variation, surface pH, uniformity of thickness, drug content, swelling index, thermal analysis, drug–excipient compatibility, moisture uptake and loss, surface morphology, …

A Care Ethical Defense Of Intergenerational Obligations, Owen Spalding

Electronic Theses and Dissertations

This paper argues that an ethic of care can justify an obligation or set of obligations to future generations. To do this, I analyze a comparable project by Thomas Randall and while ultimately agreeing with his basic conclusion, I show that he needlessly rejects arguments that would help to establish this obligation. Specifically, I defend against his critiques of Nel Noddings and Anca Gheaus. From here, I move on to show that an ethic of care centered on needs is more effective for making policy decisions than the sufficientarian model established by Randall.

Impact Of Graphene Nano-Platelets On Calcium Silicate Hydrate Formation, Weam Elmahmoud

Electronic Theses and Dissertations

Calcium-silicate-hydrate (C-S-H) is a vital component in cementitious materials, providing strength and durability. It forms during the hydration process of cement, where calcium ions react with silica-rich compounds to form a gel-like structure. The nanocrystalline units within C-S-H contribute to its unique properties and serve as a binding agent in the hardened cement paste. However, the mechanisms and impacts of nanomaterials, such as graphene nanoplatelets (GnPs), on C-S-H at the nanoscale level are not fully understood.

Incorporating GnPs into cement-based composites has shown promise in enhancing C-S-H formation and properties. GnPs possess exceptional mechanical, thermal, and electrical properties, making them …

Impact Of Flow Conditions On Graphene-Coated Soil And Geotextile Materials, Brennan Power

Electronic Theses and Dissertations

Levees are fundamental infrastructures for reducing and mitigating flood risk during extreme weather events. Unfortunately, levees do not eliminate flood risk entirely due to floods potentially exceeding a levee’s capacity. Graphene has become a significant material for enhancing the mechanical properties of materials such as concrete and soil. The focus of this study was to determine methods to coat two materials commonly used in levee sites, sand and geotextile, with graphene to determine the stability of the coating on the materials under different flow conditions simulating real-life scenarios such as wet and dry periods. These graphene-coated materials could then be …

Characterization Of Inter- And Intramolecular Non-Covalent Interactions Through Computational Quantum Chemistry, Carly Alyssa Rock

Electronic Theses and Dissertations

Computational quantum chemistry proves to be a highly effective means of exploring the nature and properties of a wide range of chemical systems that may be challenging to characterize experimentally. One area of particular interest is the investigation of non-covalent interactions, which play a crucial role in a wide variety of biological, chemical and physical processes. Obtaining accurate descriptions of systems dominated by weak inter- and intramolecular non-covalent interactions often requires sophisticated ab initio methods used in conjunction with robust basis sets. This approach, however, can become extremely computationally demanding as the size of the system of interest increases. Within …

Design, Synthesis, And Application Of Indolizine-Donor Containing Fluorophores For Near-Infrared And Shortwave-Infrared Biological Imaging, William E. Meador

Electronic Theses and Dissertations

Low energy light in the near infrared (NIR, 700 – 1000 nm), shortwave infrared (SWIR, 1000 – 1700 nm), and extended SWIR (ESWIR, 1700 – 2700 nm) has numerous important applications including fluorescence biological imaging, secure display technologies, and photodetectors. While inorganic materials have dominated each of these spectral regions, organic molecules that absorb and emit light in these regions are being heavily researched due to their high degree of molecular tunability via structure-function relationships, cheap production due to the avoidance of precious metals, ease of manufacturing through solution processability, and operation under physiological and ambient conditions. This dissertation illustrates …

Earthscibert: Pre-Trained Language Model For Information Retrieval In Earth Science, Rishabh Shrestha

Electronic Theses and Dissertations

Large Language Models (LLMs), such as Generative Pre-trained Transformers (GPT) and Bidirectional Encoder Representations from Transformers (BERT), have significantly advanced Natural Language Processing (NLP), achieving state-of-the-art results in various tasks. Notably used in systems like Google Search, these models can be domain-tuned through domain-specific pre-training. In Earth Science, where massive data is generated and made publicly available by institutions such as the National Aeronautics and Space Administration (NASA), understanding the usage of such datasets in scientific literature is critical to assessing their scientific impact.

This thesis develops and introduces EarthSciBERT, a domain-specific BERT developed for Earth Science by pre-training BERT …

Determining The Geochemical Variability Of Groundwater During Riverbank Filtration, Transfer And Injection In The Mississippi River Valley Alluvial Aquifer In Shellmound, Mississippi, Alexandra Megan Ward

Electronic Theses and Dissertations

With long-term water level decline in the Mississippi River Valley Alluvial aquifer (MRVAA), the Groundwater Transfer and Injection Pilot project is analyzing the feasibility of Managed Aquifer Recharge (MAR) to increase groundwater availability in the Delta region of Mississippi. The MAR method chosen for this project included pumping water from a well adjacent to the Tallahatchie River using riverbank filtration, transferring the water through a 2-mile pipeline, and injecting the water into the MRVAA. However, by transporting river water into the aquifer, the water quality must be examined at both the river extraction site and the injection well site. The …

Livestock Wastewater And Air Quality Management Using Microalgae, Capacitive Deionization, And Biofilters, Augustina Kwesie Osabutey

Electronic Theses and Dissertations

Wastewaters play a significant role in the negative impact of phosphorus on the environment, such as eutrophication. However, phosphorus is a limiting nutrient essential for life which has gained global attention on productive technologies for phosphorus recovery. Several technologies have been developed for phosphorus removal and recovery from wastewater to help alleviate phosphorus loss to the environment. Capacitive deionization technology, which was earlier developed for water desalination and ion removal, is actively being explored for its ability to remove phosphorus from wastewater. This review describes capacitive deionization technology (CDI) and its various types. Significant attention is given to the use …

Assessing The Economic Feasibility Of Capturing And Utilizing Carbon Dioxide From Ethanol Production In South Dakota, Makiah Stukel

Electronic Theses and Dissertations

Since the Industrial Revolution, anthropogenic greenhouse gas (GHG) emissions have spiked dramatically, prompting discussions on climate change. Mitigating climate change requires significant reductions in global carbon dioxide (CO2) emissions as CO2 is the most abundant anthropogenic GHG. A process that assists in offsetting the exponential growth in CO2 emissions is carbon capture and storage (CCS). Integrating carbon capture technology into the ethanol industry can provide an economically feasible way to achieve net reductions in CO2 emissions. The proposed work investigates the economic viability of applying CCS technologies to the 16 ethanol facilities in South Dakota (SD) and quantifies the potential …

Evaluation Of Precision Ingredient Inclusion On Production Efficiency Responses In Finishing Beef Cattle, Santana R. Hanson

Electronic Theses and Dissertations

Two randomized complete block design feedlot experiments were conducted over the course of two years. These experiments were conducted to investigate the effects of 1) evaluate the observed-to-expected ratio for ingredient inclusion using no commodity inclusion assistance technology or using commodity inclusion assistance technology; and 2) evaluate the influence that varying degrees (highly variable at random or 0.454 kg asfed tolerance for each ingredient) of accuracy on ingredient inclusion have on growth performance, carcass traits, efficiency of dietary NE utilization, and ingredient inventory management in finishing beef cattle. Experiment 1 used single source Black Angus heifers (n = 60; initial …

Understanding Human Gut Bacterial Interactions And Their Role In Colonization Resistance Against Clostridioides Difficile Using Mini-Bioreactor Array And Caenorhabditis Elegans As Model Systems, Achuthan Ambat

Electronic Theses and Dissertations

No abstract provided.

Effectiveness Of Atmospheric Cold Plasma In Inactivating Microorganisms, Nadee Shanika Kaluwahandi

Electronic Theses and Dissertations

In the food processing industry, Cold Plasma (CP) is an emerging green process with a number of potential applications. Cold plasma has mostly been used to reduce microbial counts in foodstuffs and biological materials as well as in different levels of packaging, particularly in cases where there is thermal sensitivity. Recent studies have demonstrated that CP technology is being developed for use in the food and agriculture industries. The primary focus is on the interactions between reactive species and food-borne microbes to inactivate them. The literature review discusses both proven and potential applications for cold plasma in food processing, as …

Polysaccharide-Based Hydrogel Beads For Biological Nitrogen Fixation, Prashant Dahal

Electronic Theses and Dissertations

No abstract provided.

Rye Cover Crop Termination Timing Influenced Early Corn Growth, Gene Expressions, And Yield In A No-Till System, Janet Moriles-Miller

Electronic Theses and Dissertations

No abstract provided.

Identification And Quantification Of Novel Antimicrobials, Hazera Khatun Koly

Electronic Theses and Dissertations

No abstract provided.

The Effect Of Work Accommodations On The Risk Of Relapse In Physicians And Nurses With Co-Occurring Substance Use And Mental Health Disorders, Corbin Watson

Electronic Theses and Dissertations

Accessing reasonable work accommodations may be difficult for healthcare professionals with impairments, particularly those who suffer from mental health and substance use disorders (MHSUD). The use of workplace accommodations by medical professionals who also have MHSUD may experience barriers to their accommodations. The article explores (1) the difference between the types of work accommodations and (2) the types of barriers healthcare professionals with co-occurring mental health and substance use disorders experience and how they impact their risk of relapse. Implications for physicians, nurses, and counselors are discussed.

Distraction By Any Other Name? The Impact Of Music On Social Exclusion Recovery, Sydney G. Wicks

Electronic Theses and Dissertations

Across three experiments, this work investigated whether the effectiveness of music on social exclusion recovery was greater than that of other distracting noises. I hypothesized that listening to music would be effective in improving needs satisfaction after instances of rejection (being explicitly disliked; Study 1) or ostracism (being ignored; Studies 2-3). Further, I examined whether this effectiveness was mediated by reduced rumination, increased emotional engagement (feeling moved by audio), and increased parasocial experiences (sense of one-sided psychological bonds). Ultimately, music was shown to be effective (albeit, relatively) in improving one’s needs when compared to a baseline condition. Additionally, listening to …

Development And Characterization Of Fluconazole Solid Lipid Nanoparticles, Isha Kalaria

Electronic Theses and Dissertations

Solid Lipid Nanoparticles are first-generation colloidal carriers based on lipids, with their sizes ranging from 40-1000 nm. They are composed of biocompatible lipids, which are dispersed in an aqueous medium containing surfactant to form a lipid core. The active pharmaceutical ingredient is dispersed uniformly in the lipid matrix of the formulation. Water, along with lipids, is one of the major constituents in the preparation of solid lipid nanoparticles. Various active ingredients have adverse effects when taken by oral route and hence can be formulated as alternative drug delivery methods for the reduction of side effects. The objective of the present …

Evaluation Of Feed Additives And Delivery Method For Receiving And Finishing Cattle, Thiago Lauro Maia Ribeiro

Electronic Theses and Dissertations

Trace minerals (TM) and vitamins are essential to improve production output and efficiency in beef cattle. The first experiment was conducted to investigate if the delivery method of TM and Saccharomyces cerevisiae yeast culture influence growth performance and hepatic TM content of receiving steers. The second experiment evaluated the effect of supplemental protected B - vitamins to finishing steers. Experiment 1 used Charolais x Angus steers calves (n = 192; 256 ± 14 kg) in a 49-d receiving experiment. Within 36h of weaning, steers were weighed, allotted to 24 pens (n = 8 steers/pen; 8 pens/treatment) and randomly assigned to …

In-Vivo Assessment Of A Direct-Fed Microbial On Lactation Performances, Blood Biomarkers, Ruminal Fermentation And Microbial Abundance In Transition To Mid-Lactation Holstein Cows, Marcela Bulnes Lopez

Electronic Theses and Dissertations

The transition period is a crucial stage in the lactation cycle and can lead to significant metabolic changes in cows. The use of nutritional interventions, such as direct-fed microbials, may assist cows during the transition from pregnancy to early lactation, reducing the occurrence of metabolic disorders and improving overall health. The primary goal of this study was to assess the effects of a commercial rumen-derived directfed microbial (DFM) product (Galaxis™ Frontier (GF) Native Microbials Inc., CA, USA) on various factors such as performance, blood biomarkers, rumen fermentation, and bacterial population in dairy cows during the transition period up to 100 …

Stem And Pre-Health Students’ Diminishing Online Conversation Volume Regarding Majors And Careers Within The Field: Why Higher Education Should Care, Susan Roh

Electronic Theses and Dissertations

The purpose of this study was to determine the STEM and pre-health online mention volume change regarding STEM and pre-health majors, careers, and universities, with the data collection period encompassing August of 2018 through June of 2021. We evaluated if the mention sentiment shifted between academic year periods. The data gathered for this study was procured in collaboration with Campus Sonar and the social-listening tool of Brandwatch, which allowed for specifications of the data collected. Kruskal-Wallis tests were used to determine the means of the majors, careers, and universities mentions and mean sentiment volumes. Changes in not only online conversation …

Development Of Corn Kernel-Based Biocomposite Films For Food Packaging Applications, Swastika Bera

Electronic Theses and Dissertations

Most of the current and active food packaging resources and methods are nonbiodegradable and nonrenewable therefore harmful to the environment. Due to this, alternate sources of food packaging materials are in high demand. In this study, a bio-composite film has been developed, with Corn kernel powder as fiber reinforcement which is mixed with gelatin, and lignin two biopolymers as the matrix. The effect of Corn Kernel (CK) reinforcement on the Gelatin/Lignin (G/L) matrix on mechanical and barrier properties has been studied. CK has shown great potential as reinforcement to natural polymer, gelatin, and lignin (G/L) for food packaging applications as …

Development Of Novel Cellular Assay Model And Therapeutic Deep Eutectic Solvents To Optimize The Activity Of Anticancer Agents, Nizam Uddin

Electronic Theses and Dissertations

Multidrug resistance (MDR) is the major burden behind chemotherapeutic treatment failure. It is the principal mechanism by which cancer cells evade chemotherapeutic treatment. As a result, aggressive cancer cells survive and continue uncontrolled cell division. Multidrug resistance affects survival rate of almost all types of cancer patients and death toll rises at an alarming rate. There are seven different mechanisms for evolving MDR. The most common mechanism in efflux activity of overexpressed ABC transporters. MRP1 is a prominent ABC transporter that pumps out a wide variety of anticancer drugs from the cells and thereby reduces intracellular drug concentrations and develops …

Design, Synthesis, And Biological Evaluation Of Novel Steroidal Analogs: Potential Anticancer Agents, Trevor Ostlund

Electronic Theses and Dissertations

Cancer is a malicious disease with low survivability rates primarily due to lack of reliable treatment options. Treatments are often non-specific for patients, and cancer resistance to treatment is becoming more prevalent as fast as new therapies are created. Previous studies in our laboratory have focused on the Epidermal Growth Factor Receptor (EGFR) and its downstream kinase family members as a key target for cancer. This cascade controls cell proliferation, anti-apoptotic effects, cell regulation, and other survival factors. Additionally, ABC transporters, responsible for efflux of chemotherapeutic material from cells, are key targets to combat drug resistance. We first evaluated a …

Physically Adjusted Neutral Detergent Fiber System: Effects Of Dextrose And Non-Forage Fiber On Performance, Feeding Behavior, Digestibility, Rumen Fermentation And Rumen Bacterial Abundance In Dairy Cattle, Jorge Luis Bonilla Urbina

Electronic Theses and Dissertations

The newly proposed physically adjusted NDF system (paNDF) system aims to maintain a favorable rumen environment (e.g., pH) by taking into account both the physical and chemical composition of diet. Thus, the objective of this study was to determine the effects of water-soluble carbohydrates (WSC) and non-forage NDF inclusion in a paNDF system on production performance, rumen pH and fermentation profile, rumen bacterial abundance, feeding behavior and nutrient digestibility in late-lactating Holstein cows. Nine fistulated multiparous Holstein cows (2nd and 3rd parity) were used in a triplicated 3×3 Latin Square experiment. Each period lasted for 21 d with 14 d …