Digital Commons Network^™

Advising Minority Pre-Med Students: Perceptions Of Pre-Med Advisors At Institutions In The Southeastern Association Of Advisors In The Health Professions Region, Victoria Street

Electronic Theses and Dissertations

The purpose of this qualitative study was to explore pre-medical advisors’ perceptions on their role in the pathway to medicine for students historically underrepresented in medicine (URiM) and to gain insight into barriers these students face. While a small amount of research exists on the perspective of URiM pre-medical students on the pathway to medicine, no analysis has been conducted on the role pre-medical advisors play. The underlying framework of this research study focused on the experience of advisors through the lens of academic advising approaches, self-authorship theory, and capital theory to make a strong collective framework to begin understanding …

The Stringent Response In Pseudomonas Aeruginosa Influences The Phenotypes Controlled By The Gac/Rsm System, Michael Shawn Hooker

Electronic Theses and Dissertations

Pseudomonas aeruginosa is a ubiquitous, opportunistic pathogen that causes acute and chronic infections. Infection is typically initiated via motile and virulent strains. After exposure to stressors, acute infections make both genotypic and phenotypic switches to a chronic, sessile strain. This is due to intricate regulatory networks directing gene expression in response to stressors. One network, GacA/GacS, has been established to control virulence factors. The stringent response of bacteria is mediated by alarmones produced primarily by RelA which responds to starvation.

To study the effect of the stringent response on the virulence switch. A series of experiments were run in both …

Unsupervised Dimension Reduction Techniques For Lung Diagnosis Using Radiomics, Janet Kireta

Electronic Theses and Dissertations

Over the years, cancer has increasingly become a global health problem [12]. For successful treatment, early detection and diagnosis is critical. Radiomics is the use of CT, PET, MRI or Ultrasound imaging as input data, extracting features from image-based data, and then using machine learning for quantitative analysis and disease prediction [23, 14, 19, 1]. Feature reduction is critical as most quantitative features can have unnecessary redundant characteristics. The objective of this research is to use machine learning techniques in reducing the number of dimensions, thereby rendering the data manageable. Radiomics steps include Imaging, segmentation, feature extraction, and analysis. For …

Perceptions Of Primary Caregivers About Managing Their Child’S Transition To Kindergarten: A Mixed-Methods Study, Kristy Lynn Castanon

Electronic Theses and Dissertations

The study aimed to explore the perceptions of primary caregivers as they manage their child’s transition to kindergarten. The study used a mixed-methods explanatory sequential design consisting of two phases. In phase 1, 64 primary caregivers of children transitioning to kindergarten completed the Kindergarten Caregiver Perceptions survey. Phase 1 participants were recruited from K-Camp, a program designed to support families and children during the transition. Descriptive statistics were analyzed to identify the concerns of caregivers, investigate their desired information and support, examine their involvement in transition activities, and understand caregivers’ perceived level of self-efficacy in managing their child’s transition to …

Identifying Taphonomic Distribution Patterns At The Gray Fossil Site, Shawn Haugrud

Electronic Theses and Dissertations

Since the early days of the discovery of the Gray Fossil Site (GFS), meticulous efforts to preserve the spatial data were a priority. Direct surveying of fossils prior to recovery, as well as grid mapping the site, provided relative spatial data within a square meter. Such efforts meant that even fragments and microfossils, recovered during the screening operations and eventual concentrate picking, maintained some spatial data. Available spatial data are used to identify smaller deposits within the greater system, as well as non-random distribution patterns among a number of GFS taxa. Patterns are particularly pronounced in the large-bodied taxa, Teleoceras …

Inhibiting Survival Of Salmonella During Desiccation Through The Use Of Naturally Occurring Signals, Joseph Headrick

Electronic Theses and Dissertations

A rising problem in agriculture is the increase of antibiotic-resistant Salmonella cases associated with chicken eggs, which transmit infection to humans. To counter this, new approaches to combat Salmonella in chickens and desiccated on eggshells are vital in the prevention of human foodborne illness. Disrupting signaling pathways with naturally occurring compounds provides a potential novel avenue for prevention of Salmonella infections, as this would disrupt sensing of these environments and inhibit subsequent optimal gene expression. Starting with signals identified in previous studies, salicylic acid was found to inhibit Salmonella desiccation survival on both eggshells and plastic. To expand upon this, …

Witness, Revival, Testimony, Laura Ann Schroeder

Electronic Theses and Dissertations

The artist, Laura Ann Schroeder, discusses her Master of Fine Arts thesis exhibition, Witness, Revival, Testimony, which was installed at Tipton Gallery in Johnson City, TN from March 2, 2023 through March 31, 2023, with a public reception held on March 24, 2023. The exhibition consisted of a collection of sculptural works and installations that evoke scenes and memories from the artist’s childhood. This body of work deconstructs the traditional family dynamic and the private domestic space through recreations of everyday life. The artworks are primarily made with repurposed consumer textiles and techniques like stitching and quilting that have historically …

Consuming The World: Poetic Appetite, Memory, And Identity In Li-Young Lee’S Food Poems, Claire Liszka

Electronic Theses and Dissertations

Food is a universal human necessity, yet food often serves more than a biological purpose as it informs individual and communal identities, and even facilitates memory. This thesis explores personal memory, the development of identity, and an almost reverential connection to nature in several food poems by Li-Young Lee in Rose (1986) and Behind My Eyes (2008). Born in 1957, Lee has been writing poetry since he was young, studying under Gerald Stern in the late 1970s, and he is known for writing sublime, transcendent yet incredibly accessible and expressive poetry. This thesis gives an overview of food studies and …

Selecting Classroom Grading Practices: A Qualitative Study Exploring Teacher Experiences, Tallye Gass

Electronic Theses and Dissertations

The purpose of this qualitative research was to understand the experience of selecting grading practices for a high school math or English classroom. There is no existing research related to understanding this phenomenon. This phenomenological study included three participants who were purposefully selected based on specific criteria: They must teach math or English in grades 9, 10, 11, or 12 and have at least three years of teaching experience. The participants were interviewed using videoconferencing software, and the interviews were recorded and transcribed. Open and axial coding was used to analyze the data. The theoretical framework applied for the interpretation …

Spin Trapping Behavior Of Some Selected Melatonin Derivatives For Hydroxyl Radicals: A Computational Study, Aaron Caesar

Electronic Theses and Dissertations

Melatonin (N-acetyl-5-methoxytryptamin, MLT) is a naturally occurring antioxidant which has shown some potential for use as a spin trap. Spin traps react with short lived hydroxyl radicals (HO·) to produce more stable products called spin adducts which may be characterized by electron paramagnetic resonance spectroscopy. However, the relative stability of hydroxyl spin adducts of melatonin derivatives (MLTD) compared to 2-hydroxymelatonin (HO-MLT) has not been examined computationally. Computational studies have been done on four selected MLTD; methylmelatonin (Me-MLT), chloromelatonin (Cl-MLT), cyanomelatonin (CN-MLT), and nitromelatonin (NO₂-MLT). Geometry of the structures were optimized at the HF/6-31G(d), cc-pVXZ, (X=D and T) and …

Mankind Is Machine: A Monstrous Posthuman Reading Of Philip K. Dick’S Selected Works, Gabriel Davis

Electronic Theses and Dissertations

The works of Philip K. Dick act as an ideal template for readers to explore what it means to be human in a technologically dominated world. Dick’s emphasis on the usage of androids and artificial intelligence as literary monsters allows for a posthuman reading of the traditional literary monster, notably in how their uncanny nature and behavior helps reveal the synthetic tendencies of humanity. In Do Androids Dream of Electric Sheep?, “Imposter,” and “I Hope I Shall Arrive Soon,” each narrative incorporates artificial intelligence and androids acting as others to reveal the machine-like qualities of Dick’s human characters. This …

Comparative Characteristics Of Integrin Αdβ2 Binding To Native Fibrinogen And Fibrinogen Modified By Dha Oxidation During Inflammation, Ajibola Ilesanmi

Electronic Theses and Dissertations

2-ω-carboxyethylpyrrole (CEP) is a product of docosahexaenoic acid (DHA) oxidation, which forms covalent adducts with different proteins. CEP-modified proteins can interact with macrophage receptor, integrin αDβ2. This study aims to compare αDβ2 binding to its physiological ligand, fibrinogen, and CEP-modified fibrinogen, which is formed during inflammation. We hypothesize that modification of fibrinogen changes its ligand-binding properties to integrin αDβ2 which can affect macrophage migration and retention. Recombinant αD I-domain and αDβ2-transfected HEK293 cells were used for the experiments. Using biolayer interferometry, we found that the affinity of αD I-domain binding to fibrinogen-CEP was higher than fibrinogen and inhibited by the …

Biotic And Abiotic Factors Contributing To The Invasion Success Of Microstegium Vimineum In Eastern Deciduous Forests., Kimberly Koenig

Electronic Theses and Dissertations

Forest managers face multiple challenges in maintaining woodland systems, including climate change, habitat destruction and fragmentation, and the invasion of novel species. Invaders can change microclimates, alter nutrient cycling and understory habitat, and outcompete native species, leading to native species population declines and reduction in species richness. To effectively combat plant invasions it is necessary to first understand factors contributing to invasive species spread, including the complex interactions between invaders and native biota. This dissertation investigates the abiotic conditions and biotic interactions associated with invasion success of the non-native grass Microstegium vimineum, which is a species of great concern …

The Conceptual Compression Of Space And Time As Intimated In The Depiction Of The Horse In China, Circa 1250 Bce-Ce 400., Robert Jones

Electronic Theses and Dissertations

This dissertation examines the horse in ancient China, from before its domestication in the 13th century BCE to the fourth century CE. The revolutionary utilization of the mounted horse influenced contemporary concepts of time and space. The topics include the history of equid domestication in Eurasia, horse-drawn vehicles and riding, the introduction of the horse-drawn chariot from Shang China to its decline in Eastern Zhou; the rise of cavalry in China in the fourth century BCE; and the administrative, martial, symbolic and religious roles given the horse up to the Han dynasty; the early Chinese world view as dictated by …

Development Of Nonorthogonal Wavefunction Theories And Application To Multistate Reaction Processes., Emily Kempfer

Electronic Theses and Dissertations

Many prominent areas of technological development rely on exploiting the photochemical response of molecules. An application of particular interest is the control of molecular switches through a combination of different external stimuli. However, despite significant advances in theoretical approaches and numerous cases of successful application of theory, simulating photochemical reactions remains a computational challenge. Theoretical methods for describing excited states can be broadly divided into single-reference response methods and multireference methods. Single reference methods provide reliable semiquantitative results for single excitations. However, these methods cannot describe double-excited states, systems with strongly correlated ground states, or regions of degeneracy on the …

Engineering 3d Architected Metamaterials For Enhanced Mechanical Properties And Functionalities., Huan Jiang

Electronic Theses and Dissertations

Compared with conventional materials, architected metamaterials have shown unprecedented mechanical properties and functionalities applications. Featured with controlled introduction of porosity and different composition, architected metamaterials have demonstrated unprecedent properties not found in natural materials. Such design strategies enable researchers to tailor materials and structures with multifunctionalies and satisfy conflicting design requirements, such as high stiffness and toughness; high strength with vibration mitigation properties, etc. Furthermore, with the booming advancement of 3D printing technologies, architected materials with precisely defined complex topologies can be fabricated effortlessly, which in turn promotes the research significantly. The research objectives of this dissertation are to achieve …

Super P-Sulfur Cathodes For Quasi-Solid-State Lithium-Sulfur-Batteries., Milinda Bharatha Kalutara Koralalage

Electronic Theses and Dissertations

Lithium-Sulfur (Li-S) batteries have become a promising candidate to meet the current energy storage demand, with its natural abundance of materials, high theoretical capacity of 1672 mAhg-1, high energy density of 2600 Whkg-1, low cost and lower environmental impact. Sulfide based solid state electrolytes (SSEs) have received greater attention due to their higher ionic conductivity, compatible interface with sulfur-based cathodes, and lower grain boundary resistance. However, the interface between SSEs and cathodes has become a challenge in all solid-state Li-S batteries due to the rigidity of the participating surfaces. A hybrid electrolyte containing SSE coupled with a small amount of …

The Alphaviral Capsid Protein Inhibits Irak1-Dependent Tlr Signaling To Promote Pathogenesis., V. "Trey" Landers

Electronic Theses and Dissertations

Alphaviruses are positive-sense RNA viruses spread by mosquitos. They can cause a severe multi-joint febrile arthritis or encephalitis resulting in death or life-long cognitive impairments. To date there are no approved antiviral therapeutics or vaccine strategies for the treatment of alphaviruses creating a critical need to better understand the host pathogen interactions of alphaviruses that enable pathogenesis. It is known that alphaviruses evade innate immune responses by shutting down host transcription and translation, but these methods are dependent on viral gene expression and leave a critical time frame during early infection before viral gene expression has begun that the virus …

The Well-Tempered Android: Philosophical Posthumanism In Science Fiction Cinema., Cody Gault

Electronic Theses and Dissertations

This dissertation examines philosophical posthumanism as a means for critical analysis of the interaction between humans and nonhuman androids in select science fiction cinematic universes. The interaction is analyzed through several facets, notably the interactions between humans and nonhuman androids, particularly as interactions between the human and nonhuman are often sites of violence. Chapter one is an introduction. Chapter two describes the development of philosophical posthumanism from humanism, also including an analysis of philosophical posthumanism, and how it can be used as a critical lens. Chapter three begins an analysis of science fiction cinema by examining the Blade Runner films …

Interrogating Autism From A Multidimensional Perspective: An Integrative Framework., Mohamed T. Ali

Electronic Theses and Dissertations

Autism Spectrum Disorder (ASD) is a condition characterized by social and behavioral impairments, affecting approximately 1 in every 44 children in the United States. Common symptoms include difficulties in communication, interpersonal interactions, and behavior. While symptoms can manifest as early as infancy, obtaining an accurate diagnosis may require multiple visits to a pediatric specialist due to the subjective nature of the assessment, which may yield varying scores from different specialists. Despite growing evidence of the role of differences in brain development and/or environmental and/or genetic factors in autism development, the exact pathology of this disorder has yet to be fully …

Lung Cancer-Kidney Crosstalk Enhances Cisplatin-Induced Nephrotoxicity., Andrew Orwick

Electronic Theses and Dissertations

Cancer patients represent a unique patient population with increased susceptibility to kidney disease. Drug-induced acute kidney injury (AKI) in cancer patients is a common problem. Cisplatin is a highly effective treatment used in many solid organ cancers. However, cisplatin causes AKI in 30% of patients, increasing the risk of chronic kidney disease (CKD) development. The kidneys maintain homeostasis of the body’s extracellular fluids and removing waste products. The kidneys filter nearly 170 liters of fluid a day and must reabsorb over 99% of the filtrate. The reabsorption occurs in tubule cells throughout the nephron, which are highly enriched in mitochondria …

Regeneration: Restorative Theatre Practice In Theatre Education., Sarah Elston

Electronic Theses and Dissertations

Regeneration: Restorative Theatre Practice in Theatre Education aims to harness the holistic benefits of theatre as a discipline and create an intentional restorative practice for performers. This thesis serves as a proposal; an attempt to prioritize restorative and self-care practices within the theatre industry, specifically pre-professional training programs. This proposal takes the form of a curriculum that builds upon the current model of theatre training (Voice, Movement, Acting) with the addition of Regeneration. Regeneration provides theatre artists with specific areas of study to offer the psychosocial support a theatre artist may need during their pre-professional training. This thesis will discuss …

Soluble Epoxide Hydrolase Inhibition: A Novel Therapeutic Strategy For Alcohol-Associated Liver Disease., Jeffrey Warner

Electronic Theses and Dissertations

Introduction Alcohol-associated liver disease (ALD) is a common chronic liver disease and healthcare burden, and a spectrum of pathologies ranging from steatosis to steatohepatitis, fibrosis, and alcohol-associated hepatitis (AH). Despite its prevalence, there are limited effective therapeutic options for the treatment of ALD/AH. Previous evidence suggested that inhibition of soluble epoxide hydrolase (sEH), a lipid metabolism enzyme which degrades beneficial metabolites of dietary polyunsaturated fatty acids, may be a beneficial strategy. The central hypothesis of the current dissertation is that sEH inhibition will ameliorate alcohol-associated liver injury and inflammation in mouse models of ALD. Methods To determine the efficacy of …

Clustering And Analysis Of G Quadruplex Sequences., Aryan Neupane

Electronic Theses and Dissertations

G quadruplex structures are secondary structures located throughout the genome of various organisms with involvement in regulatory functions in different transcription, translation, genome stability, epigenetic regulation as well as cell division. Even with the diverse acknowledgement of G4 structure in vivo, there are no current search tools for G quadruplexes based on already identified G quadruplexes and identified families across different genomes based on sequence diversity. Construction of families of G4 sequences and identifying their polymorphisms within disease and disorders will lead to a better understanding of their functional roles and will further research into the biophysical modeling of interactions …

Understanding The Impacts Of Global Change: From Students To Microbes., Kylea Garces

Electronic Theses and Dissertations

Global change is a crucial process, affecting every organism, from the billions of humans on earth, to the billions of microbes in the soil belowground. Evaluating the impacts of the many drastic changes associated with global change is essential in advancing our understanding in how to mitigate these consequences. Alongside the production of basic ecological knowledge associated with these environmental changes, improving education practices to promote science literacy surrounding global change is another step towards a more optimistic future. This dissertation investigates global change from two standpoints: ecologically, where increased atmospheric nitrogen (N) deposition alters plant-fungal endophyte symbiosis, and pedagogically, …

The Evolution Of Empathy: Through The Lens Of A Rodent Model., Caroline Driscoll-Braden

Electronic Theses and Dissertations

Empathy is the capacity to be affected by and share the emotions of others, to discern the circumstances prompting another’s emotional state, and to identify with another by adopting their perspective. Research investigating the empathically motivated behavior of rats can help inform the evolutionary history of empathy and provide additional support of the continuity of empathy in animals and humans. In this dissertation, I examine the helping behavior of rats to explore the complexities of rodent empathy. In Chapter I, I review the multiple layers of empathy and describe both historical and contemporary research examining empathy in non-humans. I explain …

Adverse Birth Outcomes: Investigating The Role Of Nativity And Perceived Racial Discrimination Among Black Mothers Enrolled In Des Moines, Iowa Healthy Start., Kendria Kelly-Taylor

Electronic Theses and Dissertations

Birth outcomes for Black women in the United States (US) are disproportionately worse in comparison to non-Black women, even when controlling for potential confounders. Existing studies suggest foreign-born (FB) Black women present better birth outcomes in comparison to US-born (USB) Black women. Also, the longer FB Black women live in the US, the more their perinatal health advantage diminishes. Racial discrimination has been hypothesized as a potential reason for this decline. This dissertation investigates the relationship between nativity and adverse birth outcomes while also exploring how the reporting of racial discrimination impacts birth outcomes among FB and USB Black mothers …

Identification Of A Role Beyond Iron Acquisition For Yersiniabactin During Yersinia Pestis Infection., Sarah Price

Electronic Theses and Dissertations

Yersinia pestis is a Gram-negative re-emerging bacterial pathogen that is responsible for bubonic, septicemic, and pneumonic plague. Y. pestis and other bacteria require transition metals, such as iron, zinc, and manganese, to maintain intermediary metabolism, transcriptional regulation, and virulence. To inhibit infection, eukaryotic organisms have developed distinct mechanisms, called nutritional immunity, to sequester these important nutrients from invading bacteria. For pathogens to colonize the vertebrate host, they have evolved dedicated acquisition systems for transition metals. During infection, Y. pestis overcomes iron limitation by secreting the siderophore yersiniabactin. Additionally, Y. pestis requires zinc for infection and utilizes high affinity transporters to …

Barriers And Facilitators Of Dairy Consumption Among Individuals With Metabolic Syndrome., Kofi Amoh-Mensah

Electronic Theses and Dissertations

About 35% of the United States adult population meets the criteria for metabolic syndrome, representing about 85 million individuals. Consuming dairy products protects against the development of the metabolic syndrome and protects against the development of complications associated with it. However, approximately 10% of the U.S. population meets the daily recommendation for dairy products. Information about the use of dairy products among people living with metabolic syndrome is relatively unknown, even though it will benefit them the most. About 49% of respondents met the guidance of three servings per day, and the most common facilitator was access to dairy products.

Children's Beliefs About Hierarchical Structures And Relationships., Megan Norris

Electronic Theses and Dissertations

Children are surrounded by social structures such as families, schools, and workplaces which are often arranged hierarchically with some people holding more power than others. This dissertation explores how children think about hierarchical relationships and more complex hierarchical structures. In Chapter 2, children were asked to evaluate the traits of people who hold hierarchically dominant and subordinate social roles. With age, 4- to 6-year-olds increasingly inferred that dominant individuals have social power and they deferred to their instructions (Chapter 2, Study 1). Furthermore, 5- and 6-year-olds attributed knowledgeability to individuals with dominant social roles but overall children did not prefer …