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Articles 1141 - 1170 of 10916
Full-Text Articles in Entire DC Network
Co-Flowering Community Effects On The Relative Contribution Of Pollen Quantity And Quality Limitation To The Reproductive Success Of Four Clarkia Species, Emma Moore
Electronic Theses and Dissertations
More than 60% of plant populations experience low pollen availability which limits seed production (pollen limitation). Pollen limitation occurs due to low quantity or quality of pollen delivered to stigmas. Despite its ubiquity in nature, to date we still have limited understanding of the drivers of pollen limitation in plant communities. Plants typically occur in diverse communities where pollinator sharing is common and can influence quality and quantity aspects of pollen limitation. Co-flowering species can attract larger numbers of pollinators or they can compete for pollinators affecting pollen loads on stigmas. Pollinator competition may also lead to higher rates of …
Understanding The Role Of Sabp2-Interacting Protein (Sip) 428: An Nad+-Dependent Deacetylase Enzyme In Abiotic Stress Signaling Of Nicotiana Tabacum, Mariam Onabanjo
Understanding The Role Of Sabp2-Interacting Protein (Sip) 428: An Nad+-Dependent Deacetylase Enzyme In Abiotic Stress Signaling Of Nicotiana Tabacum, Mariam Onabanjo
Electronic Theses and Dissertations
Abiotic stresses are constantly rising and pose a very high risk to global agricultural productivity and food security. Some plants have evolved several innate pathways for defense against these stresses. Hence, understanding stress signaling pathways can help develop crop plants with higher stress tolerance. The salicylic acid-mediated signaling pathway is important in plants experiencing biotic and abiotic stresses. In previous studies, SABP2-Interacting Protein (SIP-428) has been shown to be a negative regular of plant growth under abiotic stress. This study aimed to investigate the roles of SIP-428 in the ROS signaling of tobacco plants. We investigated transgenic RNAi-silenced lines of …
“Just As Scared As I Am”: Daughters’ Perspectives Of The Impact Of The Overturning Of Roe V. Wade On Mother-Daughter Reproductive Conversations, Casadie Smith
Electronic Theses and Dissertations
Existing literature has identified mothers as the primary reproductive educators of their daughters and has determined mother-daughter conversations about reproduction to be an indicator of daughters’ sexual and reproductive behaviors. The overturning of Roe v. Wade on June 24, 2022, had an immediate impact on the reproductive lives of many people, including daughters. Through one-on-one interviews with 10 daughters, this qualitative study identifies three changes in mother-daughter reproductive conversations that were influenced by the overturning of Roe v. Wade: (a) The initiation of conversations, (b) the topics of conversations, and (c) the tone of these conversations. The results of this …
Gratitude And Sleep Quality In Primary Care: Mediating Effects Of Health Self-Efficacy, Health Behaviors, And Psychopathology, Heather R. Altier
Gratitude And Sleep Quality In Primary Care: Mediating Effects Of Health Self-Efficacy, Health Behaviors, And Psychopathology, Heather R. Altier
Electronic Theses and Dissertations
Sleep disturbances are prevalent among primary care patients, and psychological dysfunction, including stress, anxiety, and depression, are robust contributors to poor sleep health. Yet, the presence of potential protective characteristics, such as health self-efficacy and engaging in adaptive health behaviors, may mitigate such outcomes. Gratitude (i.e., recognition and appreciation of experiences, relationships, and surroundings), a positive psychological cognitive-emotional characteristic, may serve as a catalyst of these beneficial downstream effects, given its association with improved health functioning and sleep. In a sample of primary care patients (N = 869) from 50 urban and 30 rural practices in Germany, health self-efficacy …
Use Of Transposon Screening For Salicylic Acid-Assisted Desiccation Killing In Salmonella, Shannon D. Elliott
Use Of Transposon Screening For Salicylic Acid-Assisted Desiccation Killing In Salmonella, Shannon D. Elliott
Electronic Theses and Dissertations
Salmonella enterica serovar Typhimurium is one of the most prevalent food-borne pathogens, affecting millions around the world every year, making it a threat to global health. Salmonella possesses the ability to survive the normally lethal condition of desiccation, however, discovery of the genes and mechanisms behind this phenomenon are still ongoing. Using a transposon mutagenesis approach to construct a broad transposon library, this study aimed to uncover genes that may be contributing to changes in Salmonella’s survivability under desiccation, particularly when exposed to the antimicrobial molecule salicylic acid. Building on previous findings showing salicylic acid can alter cell viability …
The Old Family Clock: Exploring High Variation Of Chronotype In The Common House Spider, Parasteatoda Tepidariorum, Caitlin Jones
The Old Family Clock: Exploring High Variation Of Chronotype In The Common House Spider, Parasteatoda Tepidariorum, Caitlin Jones
Electronic Theses and Dissertations
Circadian rhythms are often tightly confined around a mean of 24 hours with little variation in traditional model organisms in the absence of environmental time cues. Some spider species fall well outside this normal range with mean periods of 18 hours and variation around these means of 6 hours or more. This extreme variation in circadian rhythm is not well-understood and is the focus of the current study. Using Parasteatoda tepidariorum as a model organism, we investigated whether variation in eight circadian parameters could be explained by genetic variability, environmental conditions, or an endogenous feature of the circadian system of …
Mapping The Binding Site Within Integrin D2 For Carboxyethylpyrrole (Cep)-Modified Proteins, Afia Prema
Mapping The Binding Site Within Integrin D2 For Carboxyethylpyrrole (Cep)-Modified Proteins, Afia Prema
Electronic Theses and Dissertations
Neutrophils and macrophages accumulate at sites of inflammation and cause chronic inflammation leading to various diseases. Therefore, to better understand chronic disease pathways it is important to investigate the properties of macrophage accumulation in inflamed tissues. The I-domain of the macrophage receptor integrin aDb2 plays a vital role in macrophage retention by binding to CEP (carboxyethyl pyrrole), a ligand available at inflammatory sites. This thesis mainly focuses on evaluating the binding site within integrin aDb2 that binds carboxyethyl pyrrole (CEP)-modified proteins. So, a recombinant plasmid construct containing the integrin I-domain was developed. Seven non-conserved …
Sound And Music Opportunities In Toddler Learning Environments, Sonia Akiko Yoshizawa
Sound And Music Opportunities In Toddler Learning Environments, Sonia Akiko Yoshizawa
Electronic Theses and Dissertations
The aim of this qualitative research was to gain an in-depth understanding of how teachers of toddlers (aged 25-36 months) described sound and music learning opportunities and experiences provided to children in their learning environments. In this research, teachers were asked how their personal and professional experiences with sound and music influenced their planning of toddlers’ sound and music learning opportunities. The design of this study was in-depth interviews of six toddler lead teachers in three childcare sites. Data were gathered through photographs, planning documents, and in-depth interviews using a university IRB-approved video conferencing program. Findings showed that all participants …
Impacts Of Urbanization On Pollination Success For Common Milkweed (Asclepias Syriaca), David Rockow
Impacts Of Urbanization On Pollination Success For Common Milkweed (Asclepias Syriaca), David Rockow
Electronic Theses and Dissertations
Urbanization is among the greatest threats to biodiversity on the planet, and is projected to increase in magnitude in coming years. This growing threat makes it important to better understand how urbanization may impact vital ecosystem services, such as pollination. Studies on the impact of urbanization on pollination vary wildly in their findings. This study analyzed multiple aspects of pollination success in common milkweed populations varying in urbanization level, including insect community composition, pollen removal/deposition, and fruit/seed production. By analyzing multiple pollination aspects we can determine the overall mechanism in which urbanization instills on the entire pollination process. Overall, urbanization …
Behavioral Indicators Of Reflective Functioning In Mother-Child Dyadic Interactions, Rachel Clingensmith
Behavioral Indicators Of Reflective Functioning In Mother-Child Dyadic Interactions, Rachel Clingensmith
Electronic Theses and Dissertations
Positive parenting practices and secure attachments are consistently linked to healthy child outcomes (Ainsworth & Bowlby, 1991; Waters et al., 2000). Research on cognitive processes that scaffold parental behaviors which contribute to secure attachment is an essential contribution to the literature, particularly given the potential for early intervention with at-risk families. Parental Reflective Functioning (PRF) is a construct of increasing interest which has been linked to secure attachments and positive child outcomes, with one commonly used self-report measure of PRF being the Parental Reflective Functioning Questionnaire (PRFQ; Camoirano, 2017; Clingensmith, 2021; Luyten et al., 2017). As such, the purpose of …
Geometric Morphometric Analysis Of Modern Viperid Vertebrae Facilitates Identification Of Fossil Specimens, Lance D. Jessee
Geometric Morphometric Analysis Of Modern Viperid Vertebrae Facilitates Identification Of Fossil Specimens, Lance D. Jessee
Electronic Theses and Dissertations
Snake vertebrae are common in the fossil record, whereas cranial remains are generally fragile and rare. Consequently, vertebrae are the most commonly studied fossil element of snakes. However, identification of snake vertebrae can be problematic due to extensive variation. This study utilizes 2-D geometric morphometrics and canonical variates analysis to 1) reveal variation between genera and species and 2) classify vertebrae of modern and fossil eastern North American Agkistrodon and Crotalus. The results show that vertebrae of Agkistrodon and Crotalus can reliably be classified to genus and species using these methods. Based on the statistical analyses, four of the …
Comparison Of The 2022 Monkeypox (Mpox) Outbreak Using Mathematical Modeling And Time Series Clustering, Mark-Daniels Tamakloe
Comparison Of The 2022 Monkeypox (Mpox) Outbreak Using Mathematical Modeling And Time Series Clustering, Mark-Daniels Tamakloe
Electronic Theses and Dissertations
Monkeypox virus (MPXV) is the causative agent of monkeypox (mpox), a rare viral disease that affects humans [1]. It is primarily found in Africa and is transmitted to humans through contact with sick animals, particularly rodents and monkeys, or through human-to-human transmission [2]. From the beginning of May 2022, cases of mpox have been recorded from non-endemic nations, and the illness has continued to be reported in other endemic nations. Majority of confirmed cases have been recorded in Europe and North America. In this thesis, we compare the spread of the outbreak across the top ten countries using a combination …
Investigation Of The Protein Components In A Periplasmic Mechanism Regulating Bacterial Morphology, Alexandra Pulliam
Investigation Of The Protein Components In A Periplasmic Mechanism Regulating Bacterial Morphology, Alexandra Pulliam
Electronic Theses and Dissertations
Salmonella is a leading bacterial cause of foodborne illness worldwide. During a previous study investigating the enzymes responsible for regulating cyclic-di-GMP concentrations, a mutant in the cyclic-di-GMP-specific phosphodiesterase STM3615 was identified that displayed a phenotype characterized by decreased survival on agar plates and a shorter bacterium length. I was able to determine that the periplasmic domain of STM3615 was responsible for this phenotype, not the enzymatic phosphodiesterase domain. Based upon a bioinformatic analysis of the protein, I then hypothesized that the periplasmic domain of STM3615 was interacting with a periplasmic protein to give rise to this phenotype. To identify this …
Extraction, Purification, And Characterization Of Potential Bioactive Compounds Produced By Janthinobacterium Lividum Tajx1901, Andy Elorm Agbakpo
Extraction, Purification, And Characterization Of Potential Bioactive Compounds Produced By Janthinobacterium Lividum Tajx1901, Andy Elorm Agbakpo
Electronic Theses and Dissertations
Underexplored environments such as soil samples continue to be an untapped source of bacterial strains with great potential to produce secondary metabolites for medicinal applications. As a result, these microorganisms represent a broad and yet unknown reservoir of new strains capable of producing these novel compounds. The current research primarily seeks to perform the isolation, purification, and characterization of secondary metabolites from a soil bacterium (Janthinobacterium lividum TAJX1901). The isolated soil bacterium was successfully cultured on rich media agar plates, followed by extraction using methanol and chloroform. The purification methods utilized include flash column chromatography, preparative thin-layer chromatography, and …
An Early Pliocene Fish Assemblage From The Southern Appalachians: Ichthyofauna Of The Gray Fossil Site, Shay Maden
An Early Pliocene Fish Assemblage From The Southern Appalachians: Ichthyofauna Of The Gray Fossil Site, Shay Maden
Electronic Theses and Dissertations
The Gray Fossil Site (GFS) preserves an early Pliocene sinkhole pond that accumulated a rich flora and vertebrate fauna. Fossils of fish are incredibly common at GFS, representing thousands of specimens recovered to date. Comparison with extant species reveals a depauperate freshwater fish fauna consisting of only two species: Lepomis sp. and Micropterus sp. The absence of fishes that are ubiquitous in modern streams suggests no perennial surface hydrologic connection between the Gray Fossil Site and the nearby Holston River. Limited opportunities for dispersal into the pond and deleterious conditions such as eutrophy and high competition may have resulted in …
Isolation And Structural Determination Of Bioactive Metabolites From The Soil Bacterium, Arthrobacter Sp. Tajx1902, Amonah Arije
Isolation And Structural Determination Of Bioactive Metabolites From The Soil Bacterium, Arthrobacter Sp. Tajx1902, Amonah Arije
Electronic Theses and Dissertations
As antimicrobial resistance persistently disrupts the treatment of microbial infection, natural product chemistry has played a significant role in identifying novel drugs with novel modes of action critical to getting ahead of resistance. The primary goal of this project is to extract and identify potential novel antimicrobial natural products produced by Arthrobacter sp. Although underexplored, Arthrobacter sps. have been known to produce bioactive compounds with versatility; one such is a depsipeptide with quorum-sensing inhibitory activity.1 In this research, an Arthrobacter sp. TAJX1902, isolated from a soil sample, showed inhibitory activity against a filamentous indicator bacterium and a violacein-producing Janthinobacterium …
Microsporidian Spores And The Integrin Binding Loop Of The Madam Protein Are Important For Integrin Signaling And Attachment To Host Cells, Cindy L. Barrett
Microsporidian Spores And The Integrin Binding Loop Of The Madam Protein Are Important For Integrin Signaling And Attachment To Host Cells, Cindy L. Barrett
Electronic Theses and Dissertations
Microsporidia are a distant fungal pathogen that have severe clinical consequences for the immunocompromised. Previous work identified a microsporidian pathogen protein termed Microsporidian ADAM or MADAM. This protein has close sequence homology to other ADAM proteins (A Disintegrin and Metalloproteinase) in two microsporidian species, Encephalitozoon intestinalis and E. cuniculi. ADAM proteins have a wide range of functions, including binding to integrins and host signaling. It is known that many pathogens manipulate integrins to invade host cells, and it is predicted that microsporidia are also exploiting this host target. Previous work with the MADAM protein demonstrated that this protein has a …
Effects Of Environmental Pollutants On Liver Disease: Role Of The Gut-Liver Axis., Ngozi Victoria Adiele
Effects Of Environmental Pollutants On Liver Disease: Role Of The Gut-Liver Axis., Ngozi Victoria Adiele
Electronic Theses and Dissertations
Polychlorinated biphenyls (PCBs) and polystyrene (PS) microplastics are environmental pollutants associated with various diseases including toxicant associated fatty liver disease (TAFLD). Previously, exposure to Aroclor 1260 (a PCB mixture) has been shown to exacerbate TAFLD, partly through Aroclor 1260 induced gut dysbiosis. Studies has also demonstrated that PS exposure alters gut microbiome composition and induced obesity. However, the effects of Aroclor 1260 on the gut and the effects of PS on the liver are still understudied. Therefore, we hypothesize that environmental pollutants will disrupt the gut-liver axis through changes in gut and its microbiome as well as changes in liver …
Interactive Computer-Based Simulations As Exploratory Learning Activities., Derek Mcclellan
Interactive Computer-Based Simulations As Exploratory Learning Activities., Derek Mcclellan
Electronic Theses and Dissertations
Typical college lectures follow a direct instruction framework, where instructors deliver a lecture, followed by an activity. Exploratory learning flips this routine by providing students with an activity prior to instruction. Research suggests that this inversion benefits students’ conceptual understanding and ability to transfer their knowledge. The majority of exploratory learning tasks in the literature are problem-solving activities. The current work investigates the use of computer-based simulations during exploratory learning, and whether manipulating the cognitive load of the activity impacts learning. In Experiment 1, undergraduate students (N=66) were randomly assigned to explore a simulation-based circuit construction activity prior …
Why Are Measures Of Depression Imperfectly Correlated? An Empirical Investigation., Eric Joseph Smith
Why Are Measures Of Depression Imperfectly Correlated? An Empirical Investigation., Eric Joseph Smith
Electronic Theses and Dissertations
Depression remains one of the most prevalent and impactful mental health disorders worldwide. A large number of measures of depressive symptoms are currently available, all designed to assess the same underlying construct. However, the measures tend not to correlate highly with one another. Measurement error cannot fully account for this observation, suggesting that clinical heterogeneity – that is, differences in symptom coverage across measures – might contribute to the lower-than-expected correlation between measures. We conducted two concurrent studies to examine this hypothesis. In Study 1, we developed a coding scheme to categorize items into one of 10 symptom categories. We …
Novel Breath Collection Techniques For Detection Of Covid-19., James Morris
Novel Breath Collection Techniques For Detection Of Covid-19., James Morris
Electronic Theses and Dissertations
Volatile Organic Compounds (VOC) generated endogenously in the human body can be used to detect diseases that induce oxidative stress and inflammation. Breath analysis has been used for the detection of diseases such as COPD, Depression, Lung Cancer and most recently COVID-19. Methods such as Exhaled Breath Condensate (EBC), Sorbent Tubes, Solid Phase Microextraction (SPME), and silicon microreactors have shown considerable capability in extracting and concentrating trace VOC’s present in human breath. Silicon microreactors functionalized with capture agents to derivatize carbonyl compounds are effective but the overall maximum flow rate of breath sample possible during analysis is low, making direct …
The Relationships Between State-Level Economic Policies, Child Maltreatment, And Suicidal Behavior And Mortality., Yana B. Feygin
The Relationships Between State-Level Economic Policies, Child Maltreatment, And Suicidal Behavior And Mortality., Yana B. Feygin
Electronic Theses and Dissertations
Suicide has proven to be difficult to predict and prevent at the individual level,1–3 so much so that a recent analysis of individual risk assessments found a maximal positive predictive value of 5.5% for suicide death,2 and suicide continues to be a leading cause of death among adolescents age 10-19 years.4 By targeting modifiable risk factors at the population level, policy has the potential to extend our reach to people and subgroups that are missed by individual level interventions. This ecological study of adolescent suicide rates, state policies, and child maltreatment in US states from 2005-2019 and Kentucky counties from …
Injury Induced Neuroplasticity And Cell Specific Targeting Of The Lumbar Enlargement For Gene Therapy., Brandon Lee Brown
Injury Induced Neuroplasticity And Cell Specific Targeting Of The Lumbar Enlargement For Gene Therapy., Brandon Lee Brown
Electronic Theses and Dissertations
This dissertation is an examination of spinal cord injury induced neuroplasticity and tests whether noninvasive gene therapy can successfully target neurons in the lumbar spinal cord. It begins with an overview of neural control of locomotion and a brief summary of therapeutics that are used and/or in development for treating spinal anatomically characterize s subset of neurons in the spinal cord, long ascending propriospinal neurons, that are involved in interlimb coordination. Characterization of these neurons allows for subsequent evaluation of their potential involvement in injury induced neuroplasticity. This dissertation is divided into five chapters, covering spinal cord injury and therapeutics. …
Public Space And Well-Being: An Empirical Study Of Central Park In Old Louisville., Maryam Entezam
Public Space And Well-Being: An Empirical Study Of Central Park In Old Louisville., Maryam Entezam
Electronic Theses and Dissertations
Urban green spaces have been receiving attention in urban planning and the health profession in the 21st century as environmental elements that contribute to well-being. This dissertation explored the relationship between green space usage and individuals’ physical, mental, and social well-being. This empirical research focused on Central Park in Old Louisville to examine how residents use the park and whether it contributes to the well-being of residents. After exploring the existing literature, I identified four well-being indices: (1) perceived health (PHI), (2) health outcome (HOI), (3) mental well-being (MWI), and (4) social well-being (SWI). Frequent Park usage is expected …
Aurka Inhibition-Based Combination Therapy Approaches In Glioblastoma., Muge Sak
Aurka Inhibition-Based Combination Therapy Approaches In Glioblastoma., Muge Sak
Electronic Theses and Dissertations
Glioblastoma is the most common and aggressive central nervous system tumor in adults with a 6% survival rate. Decades of research for improving life expectancy and quality of life have been ineffective. The discovery of better treatment strategies is urgent to improve the survival rates for glioblastoma patients. Aurora Kinase A is a regulator of tumor progression and is overexpressed in glioblastoma. We used a specific Aurora Kinase A inhibitor alisertib in combination with DNA-damaging platinum agent carboplatin or brain-penetrating taxane TPI 287. We investigated the efficacy of these combinations in treating in vitro and in vivo tissue culture models …
Kdm5b As A Potential Epigenetic Regulator Of Cardiomyocyte Regeneration And Cell Cycle Activation., Dana Hammouri
Kdm5b As A Potential Epigenetic Regulator Of Cardiomyocyte Regeneration And Cell Cycle Activation., Dana Hammouri
Electronic Theses and Dissertations
The limited regenerative capacity of adult cardiomyocytes (CMs) is manifested in prevalent morbidity and mortality associated with ischemic heart disease. We previously demonstrated that a combination of four cell cycle factors (4F) promotes efficient cell division in differentiated CMs. The temporal transcriptional reprogramming in the 4F-transduced CMs indicates that epigenetic modifications mediate the cell cycle progression. Through small molecule screening, we evaluated the epigenetic impact on CM’s response in the 4F-transduced CMs. We identified the histone demethylase 5B (KDM5B), which through in vitro and ex vivo genetic knockdown and overexpression studies, exhibited a modulative effect on CM’s cell cycle plasticity …
Illuminating Underappreciated Mechanisms Of Receptor Regulation In Human Lymphocytes., Cassandra Woolley
Illuminating Underappreciated Mechanisms Of Receptor Regulation In Human Lymphocytes., Cassandra Woolley
Electronic Theses and Dissertations
A thorough understanding of receptor regulation is imperative to predict expression in varying contexts of disease or treatment. Lymphocyte surface receptors are often used as biomarkers and drug targets, making them particularly important for study. For receptors of debated functionality, such as the Fc receptor for IgM (FcMR), understanding regulation can also help to predict expression in vivo to supplement hypotheses of biological roles. Various mechanisms exist for altering receptor surface expression, including direct feedback mechanisms such as ligand-induced endocytosis and broader mechanisms such as transcriptional and translational control. In this dissertation, we explore selected underappreciated mechanisms of lymphocyte receptor …
Novel Insights Into Oligodendrocyte Biology From Developmental Myelination Studies In Autophagy Deficient Mice And Analysis Of Oligodendrocyte Translatome Response To Contusive Spinal Cord Injury., Michael David Forston
Novel Insights Into Oligodendrocyte Biology From Developmental Myelination Studies In Autophagy Deficient Mice And Analysis Of Oligodendrocyte Translatome Response To Contusive Spinal Cord Injury., Michael David Forston
Electronic Theses and Dissertations
Loss of myelin causes severe neurological disorders and functional deficits in white matter injuries (WMI) such as traumatic spinal cord injury (SCI). This dissertation is focused on autophagy in OL development and the OL translatome after SCI. Chapter I describes the history of myelin, OL development, and their involvement in neurodegenerative diseases and SCI. The proteostasis network, in particular autophagy, and its contributions to white matter pathology is discussed. It concludes examining advantages and disadvantages of unbiased omics tools, like RiboTag, to study transcriptional/translational landscapes after SCI. Chapter II focuses on autophagy in OPC/OL differentiation, survival, and proper myelination in …
Connectivity Of Amygdala Somatostatin-Expressing Neurons And Their Role In Taste-Guided Behavior., Jane Jeruto Bartonjo
Connectivity Of Amygdala Somatostatin-Expressing Neurons And Their Role In Taste-Guided Behavior., Jane Jeruto Bartonjo
Electronic Theses and Dissertations
The nucleus of solitary tract (NST) and parabrachial nucleus (PBN) represent the first and second central synapses of ascending gustatory information. Neural processing in these nuclei is influenced by descending input from forebrain regions such as the central nucleus of the amygdala (CeA). In mice, we have shown that somatostatin (Sst) expressing neurons of CeA that project to NST and PBN are largely distinct cell populations and optogenetic inhibition of the CeA/Sst-to-NST subpopulation increases the intake of high concentrations of quinine with no apparent effect on sucrose intake. Synaptic connectivity of these cells is needed to understand the possible mechanisms …
Incidence And Determinants Of Hypertensive Disorders Of Pregnancy In The Us: Hospitalization Discharge Rate For Preeclampsia, Eclampsia, And Gestational Hypertensions, 2016-2018., Kahir S. Jawad
Electronic Theses and Dissertations
Background: Hypertension remains one of the most prevalent medical issues in pregnancy. It contributes considerably to maternal and fetal morbidity and mortality, making it one of the most significant public health problems. Although various epidemiological studies have been conducted over the past decades to assess the disease incidence and key risk factors associated with hypertensive disorders of pregnancy, current incidence rates and trends are lacking. This is a novel and significant study because there are no current population-based incidence estimates of hypertensive disorders of pregnancy and their subtypes and very few studies with the power to explore a wide range …