Digital Commons Network^™

Tumor Infiltrating Lymphocytes: From Discovery To Clinical Application., Lewis Clayton Chew

Electronic Theses and Dissertations

This thesis explores the evolution of TIL therapy from its discovery to clinical application, focusing on its use in treating metastatic cancer. Adoptive cell therapy (ACT), particularly TIL therapy, has emerged as a promising alternative to traditional treatments like chemotherapy. This review article traces the historical development of TILs, highlighting key experiments and clinical trials that have shaped its understanding and application as a therapeutic strategy for patients with metastatic and difficult to treat cancers including melanoma. Importantly, this article highlights recent advancements, including the FDA approval of Lifileucel, and explores emerging strategies to enhance therapeutic efficacy of TILs through …

Detecting Non-Axisymmetric Instabilities In Fluid-Based Manufacturing Via Multi-View Tensor Analysis., Bidusi Khadka

Electronic Theses and Dissertations

Fluid-based manufacturing processes, such as inkjet printing and electrospinning, fabricate micro- and nano-scale structures with high precision, but are prone to complex fluid dynamics exhibiting axisymmetric and non-axisymmetric instabilities. Conventional monitoring often relies on single-camera inputs and symmetry assumptions, limiting the detection of three-dimensional anomalies like jet deflection. This study presents a novel multi-view streaming video-based anomaly detection framework to address this gap. The framework employs a modified Tensor Sequential Sampling (TSS) algorithm with edge-based sampling to capture geometric spatiotemporal features of each camera view using the videos obtained from an orthogonally positioned dual-camera setup. These features are fused with …

Emerging Solid Electrolytes For Solid-State Sodium Batteries: Synthesis And Interface Study., Xiaolin Guo

Electronic Theses and Dissertations

Over the past decade, solid-state batteries have attracted significant attention as the next-generation energy storage technology due to their higher energy density and enhanced safety. Given the abundant sodium (Na) resources relative to lithium (Li), the development of sodium-based batteries has become increasingly compelling. Within a solid-state battery, the solid electrolytes (SEs) serve the dual function of (i) electronically insulating and physically separating the electrodes, and (ii) transporting ions between the anode and cathode. To meet these essential requirements, ideal SEs must process high ionic conductivity with negligible electronic conductivity, robust structural and chemical stability, a wide electrochemical window, and …

Behavioral Manifestations Of Childhood Abandonment: African-American Men's Reflections And Strategies To Support Teenage Boys In K-12 Education, Jarmel Bell

Electronic Theses and Dissertations

The purpose of this study was to explore the behavioral manifestations of childhood abandonment as reflected in the lived experiences of African-American men and to identify strategies that may support African-American boys in K–12 educational settings. Although there has been limited documentation regarding the direct connection between childhood abandonment and behavioral challenges in school environments, this study seeks to address that gap by capturing the reflections of African-American men who experienced abandonment during their formative years. These reflections provide insight into how abandonment may shape behavior in educational spaces and what types of interventions or supports might have made a …

Assessing Post-Pandemic Engagement In The Supplemental Nutrition Program For Women, Infants, And Children (Wic) In Northeast Tennessee, Christen Minnick

Electronic Theses and Dissertations

Since 1974, the federal Supplemental Nutrition Program for Women, Infants, and Children (WIC) has provided healthy food resources, nutrition education, and provider referrals for families at risk for poor nutrition. Public health professionals have consistently presented evidence that WIC engagement reduces premature births and infant mortality, improves child health and development, and increases specialized care access for participants. While average monthly participation in WIC has increased since the program’s inception, trends indicate that only around half of eligible families have consistently engaged with the program since 2011. Research has linked declining WIC participation to administrative burden, citing learning, psychological, compliance, …

Exploring Commuter Trio Students' Student Support Services At A Public University, Travis J. Batiste Edd

Electronic Theses and Dissertations

The study explored the experiences and service needs of TRiO Student Support Services (SSS) commuter students at a public regional university in northern Louisiana. The literature review showed that while TRiO SSS programs have a demonstrated history of promoting academic success and retention for first-generation students, low-income students, and students with disabilities, little institutional research has been conducted to better understand how student residential status impacts learning outcomes and utilization of campus resources. Drawing on Astin’s theory of involvement, this study described the lived experiences of TRiO SSS commuter participants and the impact of commuting on their engagement, programmatic use, …

Sex, Riots, And Holy Water: How Modern Society Desecrates And Reconsecrates The Sacred, Jodeyah J. Mills

Electronic Theses and Dissertations

This thesis explores how modern societies desecrate and reconsecrate the sacred through rhetoric, ritual, and visual performance. Using three case studies, Nazi Germany’s transformation of Quedlinburg Abbey, the January 6th attack on the U.S. Capitol, and Sabrina Carpenter’s controversial church music video, “Feather,” this project analyzes how sacred meaning is violated and restored in religious, civic, and popular contexts. Drawing on Kenneth Burke’s dramatistic cycle and postsecular theory, it argues that desecration and reconsecration are dialogic acts that expose competing moral vocabularies within culture. Each event demonstrates that even in a secular age, people respond to ruptures of ultimate meaning …

Secondary Special Education Teachers: Perceptions On Burnout Since The Start Of Covid-19, Regina Perez

Electronic Theses and Dissertations

This study examined burnout among secondary special education (SPED) teachers following the COVID-19 pandemic, which significantly disrupted education and intensified teacher stress. Burnout, defined by emotional exhaustion, depersonalization, and reduced personal accomplishment, has been linked to teacher attrition and decreased student achievement. The problem addressed was the increased levels of burnout and stress among SPED teachers and the lack of sufficient administrative support to mitigate these effects. The purpose was to explore SPED teachers’ perceptions of burnout since the pandemic and identify the supports needed to reduce it. Using a qualitative case study design grounded in Maslach’s burnout theory, the …

Stars And Shapes: An Investigation Of Stripped Envelope Supernovae Structures Using Spectropolarimetry Observations And Hydrodynamic Models, Sabrina Desoto

Electronic Theses and Dissertations

Supernovae (SNe) are the energetic deaths of massive stars, dispersing heavy elements throughout the galaxies and shaping cosmic evolution across the universe. However, understanding the connections between the evolution of massive stars, their catastrophic demises, and the myriad of observed SNe, remains a fundamental challenge in astrophysics. My work aims to narrow this gap by integrating extensive observational data with advanced hydrodynamical simulations to better interpret SNe observations and understand the origin of their geometry. The observational component utilizes the largest spectropolarimetry dataset of stripped-envelope (SE) core-collapse supernovae (CCSNe) gathered by the SNSPOL project. Analyzing nine Type Ib and eleven …

Principal Quandles, Jesse Parrish

Electronic Theses and Dissertations

This thesis concerns principal quandles and, as a special case, Alexander quandles. A principal quandle is a coset quandle, Q(G,H, f), in which the subgroup H is trivial. If in addition the group G is abelian, then the coset quandle is called an Alexander quandle. The isomorphism types of Alexander quandles were classified [16], and some progress was made on describing the isomorphism types of principal quandles in [14] and [13]. The first part of this thesis applies the ideas used in Holmes’ paper to give a classification of the isomorphism types of principal quandles. The second …

Development Of A Non-Faradaic Impedimetric Biosensor Based On Reduced Graphene Oxide For The Detection Of Brain-Derived Neurotrophic Factor (Bdnf), Mariana N. Martins

Electronic Theses and Dissertations

Neurological disorders affect millions of people worldwide. In the case of Alzheimer’s disease (AD), the rising number of cases significantly increases global healthcare costs. Therefore, early detection of biomarkers at the onset of the disease is essential for early diagnosis. This study presents an electrochemical biosensor designed for the detection of Brain-Derived Neurotrophic Factor (BDNF) in human plasma, incorporating reduced graphene oxide (rGO) to enhance signal sensitivity. Dielectrophoresis (DEP) was employed to deposit rGO flakes on the electrode surface, improving conductivity and sensor performance. Electrochemical impedance spectroscopy (EIS) was used to monitor changes in impedance associated with BDNF binding events, …

Exploring The Impact Of Statistics Course Modality On Student Learning: A Mixed Methods Approach, Becky Kelleman

Electronic Theses and Dissertations

The importance of statistical literacy has become increasingly evident, as individuals grapple with interpreting statistics to inform critical decisions. Despite the recognized significance of statistical literacy, challenges persist in both educators’ and students’ efforts to navigate the complexities of statistics education. The purpose of this study is to explore the impact of different course modalities on undergraduate students’ academic performance in introductory statistics courses. Using Social Cognitive Theory (SCT) as a theoretical framework, this research aims to shed light on the complex dynamics influencing statistical literacy attainment. By addressing gaps and inconsistencies in the current literature, this study seeks to …

Frameworks For Repatriation: Moving Beyond Nagpra, Ashley Joplin

Electronic Theses and Dissertations

Museums and similar federally funded educational institutions have been collecting human remains since the Enlightenment era in the 1800s. Since then, these institutions have developed various collections practices that have encouraged the collection of human remains. Often unethical in nature, these collections have harmed historically marginalized communities, such as Indigenous and African American communities. While the ethics of collecting have been under scrutiny for decades, it was not until 1990 under the Native American Graves Protection and Repatriation Act (NAGPRA) that mainstream attention was drawn to the ethics of collections practices.

This thesis explores these collections practices and the repatriation …

High Frequency Dc-Dc Converter Design Optimization, Modeling And Control Based-Wbg Technology., Salah Ahmed Abdullah Eltief

Electronic Theses and Dissertations

The performance of DC-DC power converters is a cornerstone of modern electric vehicle (EV) powertrains, directly governing overall system efficiency, size, cost, and reliability. This dissertation presents a comprehensive performance analysis and optimization of DC-DC converter topologies to determine the most suitable design for high voltage EV applications. The evaluation rigorously compares efficiency, power losses, and physical size under a range of harsh operating conditions. A primary objective is to leverage Wide Bandgap (WBG) semiconductors, specifically Silicon Carbide (SiC), to push the performance boundaries of power conversion. While SiC devices are known for their superior material properties, a clear understanding …

Museums In Public Libraries: An Ethnographic Case Study Of The Blair-Caldwell African American Research Library, Yadira Y. Quintero

Electronic Theses and Dissertations

Access to information is a human right, and this thesis explores the benefits and challenges of integrating museums into public libraries by conducting an ethnographic case study of the Blair-Caldwell African American Research Library. The study's findings highlight the complexities of integration. The biggest benefit is the increased access to museum collections, information, and resources. However, challenges arise from the lack of cohesion within the museum and library disciplines, as well as strained community relations. Engaging the community is crucial for successful collaboration, emphasizing the importance of a bottom-up approach that allows for active participation. Integrating museums into public libraries …

Doughnut Economics And Strong Sustainability: Rethinking The Role Of Financial Investment, Isabelle Pierotti

Electronic Theses and Dissertations

This thesis investigates how private investment could align doughnut economic framework. Doughnut economics is a strong sustainability economic framework where the economy operates within planetary boundaries while ensuring social equity. Theories of sustainable development, weak sustainability, and strong sustainability are discussed to provide theoretical context for doughnut economics and mainstream economics. The analysis concludes that conventional, profit maximizing private investment does not support a doughnut economics system by supporting the depletion of natural resources and exacerbating social issues. Sustainable mainstream investment also fails to support a doughnut framework. Lastly, while impact investment is theoretically committed to social and financial returns, …

An Auto-Criticism: Exploration Of Professional Development For Secondary Science Educators, Mellissa Ann Pfaff

Electronic Theses and Dissertations

This auto-criticism investigates the benefits of experiential professional development for science educators by examining the reflective journey of one teacher-researcher—me—through multiple immersive learning experiences. Using narrative journaling and qualitative analysis, this study captures the influence of these experiences on my identity, instructional design, and ability to create experiential learning opportunities for students.

Rather than approaching professional development as a checklist of strategies, this research seeks to illuminate how deeply engaged, hands-on learning can transform teaching from routine delivery to embodied practice. Thematic coding revealed shifts in curriculum planning, increased responsiveness to student inquiry, and renewed clarity around the purpose of …

Archaeological Predictive Meta-Modeling In Pre-Columbian Mexico, Peter Stamm

Electronic Theses and Dissertations

Archaeological Predictive Modeling stands firmly as an important tool for Archaeologists to predict undiscovered sites from civilizations all across the globe. While powerful, this methodology is not without its own set of qualms. Striking a balance between pure a data-driven approach while also observing leading expert theories can be a complicated task. Going further, deciding on the specific domain of features to emphasize or overlook can be a challenge within itself, as one misstep can drastically change the output of model, sometimes for the worst. In addition, creating models that can expose their reasoning process can be rather difficult to …

The Resonance Of Desire: A Sonic Exploration And Guide To Recreating Disney’S Signature ‘I Want’ Songs, Aiyanna E. Riley

Electronic Theses and Dissertations

This thesis explores the sonic architecture of Disney’s Renaissance-era “I Want” songs and develops a framework for recreating their signature production style. This study analyzes how vocal timbre, microphone choices, layering, stereo placement, and mixing strategies contribute to the immersive qualities that define the Disney sound. Drawing from historical accounts, interviews with industry professionals, and technical literature, the thesis documents production practices unexamined in scholarly work. Inspired by David Gibson’s The Art of Mixing, my analyses prioritize spatial and textural qualities in Disney mixes, highlighting how sound design shapes narrative impact. The study culminates in two original compositions modeled …

Understanding The Retention Of Alternatively Certified Teachers: Key Factors And Insights, Donna M. Hardy

Electronic Theses and Dissertations

The problem addressed in this study was the high attrition rate of alternatively certified teachers

who often exit the classroom at greater rates than traditionally trained teachers, particularly

within their first 5 years of teaching. The purpose of this study was to explore the lived

experience of alternatively certified teachers to identify the support, conditions, and leadership

practices that contributed to their persistence. A qualitative phenomenological study was used,

with data collected from 14 alternatively certified teachers who work in a Central Texas school

district, utilizing semistructured interviews. Data collection methods included interviews,

member checking, and researcher field notes. Research …

The Effectiveness Of A First-Year Experience Course: A Case Study From A Public Regional University In The Central United States, Taler J. Alexander

Electronic Theses and Dissertations

Student retention has become an increasingly popular topic for colleges and universities as they look for ways to keep students amid ever-changing budget climates. Research shows that high quality first-year experience (FYE) courses can provide crucial support to new students as they enter the college or university. Additionally, many researchers have found that supporting students through their transition to a new college environment, developing their sense of belonging, and helping them get involved on campus lead to increased student retention. The purpose of this study was to explore the curriculum, format, and delivery of the FYE course at Blue University …

The Heart Of Policing: Exploring The Essence Of The Phenomenon Between Organizational Culture And Police Officer Job Satisfaction, Charles C. Palmer

Electronic Theses and Dissertations

The purpose of this transcendental phenomenological qualitative study was to explore the essence of the phenomenon between organizational culture and police officer job satisfaction among rural law enforcement agencies in Oklahoma. Retaining police officers has become an increasingly challenging task for law enforcement organizations across the United States, as high turnover, costly recruitment, and voluntary resignations continue to strain departments. While previous research has primarily examined demographic and occupational variables influencing satisfaction, limited attention has been given to how organizational culture affects the lived experiences of U.S. police officers. Guided by Edgar Schein’s organizational culture theory, this study examined how …

Breaking Barriers: Mentorship Pathways For Hispanic Women In Leadership Roles, Ana Paola Gonzalez

Electronic Theses and Dissertations

This study aimed to understand the unique lived experiences of 10 Hispanic Latinas serving in leadership roles in 2-year community colleges in Texas. As the graduation rate of Hispanic women increases, institutions must identify mentorship programs that motivate women who continue to graduate to seek leadership positions within their institutions. Through life stories and lived experiences, the study's findings illustrate that mentorship is essential to creating, but that self-determination and self-advocacy also make it possible to find paths to leadership. Through thematic analysis, three themes emerged from the data: identity and representation, mentorship and support structures, and resilience and advocacy. …

How School Mentors Build Self-Efficacy In Novice Teachers: A Single Case Study, Christina Olga Sanchez

Electronic Theses and Dissertations

This qualitative single case study with embedded units explored how school mentors build selfefficacy in novice teachers across elementary, middle, and high school settings within a single public school district in Texas. Grounded in Bandura’s self-efficacy theory, which identifies four sources of self-efficacy: mastery experiences, vicarious experiences, verbal persuasion, and emotional and physiological states, this study examined the specific strategies mentors use to build self-efficacy and foster confidence and instructional competence in novice teachers. Data were collected through semistructured interviews with eight experienced educators formally designated as mentors. Thematic analysis was employed to identify patterns in mentoring practices and their …

Effects Of Aromatherapy On Promoting Sleep In Patients With Neurological Deficits, Cherylle R. Reed

Electronic Theses and Dissertations

Reliance on sleep aids in neurological patient population can lead to negative side effects and compromise patient safety. The purpose of this doctoral nursing project was to determine if the implementation of McDonnell and Newcomb’s aromatherapy process will reduce the incidence of sleep-promoting medication administration as compared to the current practice in neurological deficit patients over 4 weeks. A quantitative, quasi-experimental design evaluated effects on sleep quality and pharmacological sleep aids by using McDonnell and Newcomb’s aromatherapy combination of lavender, bergamot, and ylang ylang essential oils placed on a cotton ball at the patient’s bedside each night. The sample included …

In Flux, Gavin G. Gilmore

Electronic Theses and Dissertations

This thesis explores my practice of non-representational, mixed media painting as a way to consider the passage of time and the shifting nature of memory. Working in layers of paper, pigment, paint, and other materials, I build and disrupt surfaces that mirror the instability of short-term memory and the gradual erosion experienced during my father’s journey with Alzheimer’s disease. Each painting becomes a palimpsest where gestures accumulate, fade, or reemerge, reflecting how memories surface, distort, or disappear.

Through this layered process, the work intertwines personal narrative with broader questions of how time is felt rather than measured. The paintings act …

Leading Beyond The Lecture: A Case Study Exploring How Community College Students Experience Their Instructors’ Positive Leadership Strategies, Mandy Morrison

Electronic Theses and Dissertations

Positive leadership, an approach to leading individuals to the point of flourishing, has been studied in corporate contexts. While the student-to-instructor relationships only distantly compare to the employee-to-supervisor dynamics, the relationships and power differential have similarities, making the pillars of positive leadership relevant in the context of higher education. Given the critical nature of student success to stakeholders in higher education and the students themselves, discovering instructor strategies that enhance student success can demonstrate an upward spiral of positivity that extends from the student, to the instructor, to the college, and ultimately to the community. Framed by leader-member exchange (LMX) …

African American Female College Students’ Experiences At Predominately White Institutions, Sh'nita Louise Mitchell

Electronic Theses and Dissertations

African American women who attend predominantly White institutions (PWIs) have historically encountered systemic challenges that include racial isolation, microaggressions, a lack of cultural understanding, and insufficient institutional support. These barriers often impact their sense of belonging, academic persistence, and overall success. I aimed to explore the lived experiences of African American women who graduated from PWIs to understand how these women navigate institutional structures and sustain their academic journeys. I aimed to examine the unique challenges and supports experienced by African American women, and to identify factors that contribute to or hinder their persistence and success at their PWI. The …

The Relationship Between Emotional Intelligence, School Culture, And School Leadership, Virginia Lorean Smith

Electronic Theses and Dissertations

Abstract

This study was a qualitative instrumental single holistic case study as outlined by Robert Stake in

1995. It focused on three research questions. The goal was to gain perspectives from teachers

and a principal on teacher retention and the culture of a campus. The emotional level of the

principal was evaluated on social awareness, self-awareness, relationship management, and self-

management by the principal taking part in an emotional intelligence assessment. The single

holistic case study approach was used, which had six phases of analyzing the data. The results

were then compared to the teachers’ interviews and surveys that were …

Professor Perspectives: Inclusion Of Students With An Intellectual Disability In Transition Programming On A College Campus, Melissa Jane Massey

Electronic Theses and Dissertations

Students with intellectual disabilities (ID) are often unemployed or underemployed compared to students who do not have ID. Transition or postsecondary programming for students with ID has increased in recent years in response to the U.S. federal requirement for special education professionals to complete transition plans before students turn 16. The requirement for transition planning in Texas is age 14, and the ARD committee including the student and parent come together to develop goals for future planning. Transition plans include information on future employment, future independent living skills, and agency connections that students with ID may need to access to …