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Design, Synthesis, And Evaluation Of Gunw-3 As A Brain Targeting Agent, Asim Najmi
Design, Synthesis, And Evaluation Of Gunw-3 As A Brain Targeting Agent, Asim Najmi
Electronic Theses and Dissertations
The blood brain barrier (BBB) is a barrier in the brain that separates the peripheral blood circulation system from the central nerve system (CNS). The barrier effectively protects the brain from xenobiotics. The BBB serves as a physical barrier through the tight junction of endothelial cells that were found to be 50-100 times tighter than that of normal endothelial cells. Different drug efflux pumps such as P-glycoproteins and multidrug-resistance proteins are found to be overdistributed on the BBB. These drug efflux pumps help pump xenobiotics out if they enter the cells and serv as an additional mechanism to prevent xenobiotics …
Differences In Running Mechanics And Tibial Plateau Dimensions Between Overweight/Obese And Healthy Weight Children, Claire Sylvestre
Differences In Running Mechanics And Tibial Plateau Dimensions Between Overweight/Obese And Healthy Weight Children, Claire Sylvestre
Electronic Theses and Dissertations
INTRODUCTION: Overweight and obese (OW/OB) children display increased knee joint loading during running, which may lead to excessive frontal plane motion and moments at the knee joints. The relationship between tibial plateau dimensions and knee vertical loading may explain the loading related injuries OW/OB children experience.
PURPOSE: Compare knee mechanics during running and tibial plateau dimensions between healthy weight (HW) and OW/OB children.
METHODS: Ten HW children and ten OW/OB children aged 9-12 participated in the study. Kinematic and kinetic data were captured as participants ran across a force platform at 3.5m/s. Tibial plateau area and density were collected by …
Evaluation Of Feeding Alternative Feedstuffs Including Hydroponic Barley Sprouts And Carinata Meal To Dairy Cattle, Rhea D. Lawrence
Evaluation Of Feeding Alternative Feedstuffs Including Hydroponic Barley Sprouts And Carinata Meal To Dairy Cattle, Rhea D. Lawrence
Electronic Theses and Dissertations
The purpose of this dissertation research was to examine alternative feed ingredients not typically found in dairy cattle diets. In total, four studies were conducted to evaluate feedstuffs such as hydroponic barley sprouts and carinata meal and how they affect cattle performance. To determine how feeding hydroponic barley sprouts would affect growing dairy heifer and lactating cow performance two feeding studies were conducted. In the first study, inclusion of 14 % (DM basis) hydroponic barley sprouts (HYD) was evaluated in an ad libitum total mixed ration (TMR) compared to a control (CON) diet on dairy heifer performance during a 12 …
Effects Of Increasing Dietary Levels Of Carinata Meal On Feeding Behavior, Performance And Carcass Characteristics Of Beef Growing Steers, Alejandro C. Casella
Effects Of Increasing Dietary Levels Of Carinata Meal On Feeding Behavior, Performance And Carcass Characteristics Of Beef Growing Steers, Alejandro C. Casella
Electronic Theses and Dissertations
The objectives of the present study are to evaluate feeding behavior, animal performance and carcass characteristics of beef growing steers fed increasing amounts of carinata meal (CM). Due to the high protein content of the CM after the oil extraction for biofuel there is an opportunity to use it as a protein supplementation in beef cattle. Twenty-four steers blocked by weight were assigned to four corn-based diets (n = 6 animals per treatment). In the three treatment diets, carinata meal replaced high-moisture corn at 5, 10, or 15%. The diets were fed using the Insentec RIC system for 138 days. …
Nutritional Transporter Mediated Drug Delivery For Cancer, Siddharth S. Kesharwani
Nutritional Transporter Mediated Drug Delivery For Cancer, Siddharth S. Kesharwani
Electronic Theses and Dissertations
Recent advancements in nanotechnology have unfolded novel opportunities in medicine, especially in targeted therapeutics and imaging for cancer. However, the majority of the existing nanotechnologies for cancer suffer from shortcomings such as (i) rapid elimination from the systemic circulation before reaching the cancer tissue. (ii) poor tumor accumulation, targeting, and penetration due to inadequate vasculature and extensive extracellular matrix in the tumor. Thus, overcoming these two limitations of nanotechnology is of considerable interests for cancer researchers. In this dissertation, we demonstrate the feasibility of glucose-modified nanoparticles (GLU-NPs) as an efficient cancer targeted-delivery system for enhancing the systemic circulation time and …
Application Of Analytical Techniques In Food Product Development, Sonali R. Pandey
Application Of Analytical Techniques In Food Product Development, Sonali R. Pandey
Electronic Theses and Dissertations
Products are analyzed in major sectors of food industry to meet regulatory standards, food safety, quality control, and research and development. Analytical and extraction techniques have been applied for simultaneous investigation of multiple product characteristics. Food analysis faces critical challenges due to the complex composition of food, leading to matrix effects that result in loss of accuracy and reliability. The analytical techniques require an efficient sample preparation to avoid or minimize matrix effects. Solid-phase extraction has been widely used to address this issue. In this dissertation, the aim is to apply analytical techniques in food product development. To accomplish this, …
Winter Snow Depth In Arctic Alaska Results In Complex Changes In Caribou Forage Quality, Jessica C. Richert
Winter Snow Depth In Arctic Alaska Results In Complex Changes In Caribou Forage Quality, Jessica C. Richert
Electronic Theses and Dissertations
Caribou (Rangifer tarandus) rely on the short growing season for much of their annual nutrition, making them susceptible to even small changes in forage quantity and quality. Body condition in the summer and fall is linked to winter survival rates and fecundity in cows, critical factors in the robustness of caribou populations. Due to a warmer, wetter climate, snowfall is predicted to increase over Alaska’s North Slope in the next several decades. Deeper snow results in higher soil temperatures, allowing microbial mineralization of nitrogen to continue throughout the winter and increasing the availability of nitrogen for plants in spring and …
Finite Mixture Of Regression Models For Complex Survey Data, Abdelbaset Abdalla
Finite Mixture Of Regression Models For Complex Survey Data, Abdelbaset Abdalla
Electronic Theses and Dissertations
Over time, survey data has become an essential source of information for modern society. However, to be effective, the structures of survey data require sampling designs that are more complex than simple random sampling. The complex sampling data collected from enormous national surveys via these complex designs ideally include sample weights that allow analysis to take account of complicated population structures. When the target of inference is the parameters of a regression model, it is crucial to know whether these weights should be incorporated into the sampling weight when fitting the model to the survey data. The finite mixture models …
Sunflower Pollinators In South Dakota: An Evaluation Of Species Composition, Abundance And Influence On Yield, Mackenzie Mattern
Sunflower Pollinators In South Dakota: An Evaluation Of Species Composition, Abundance And Influence On Yield, Mackenzie Mattern
Electronic Theses and Dissertations
In 2017 and 2018, South Dakota was the largest producer of sunflowers, Helianthus annuus L. (Asterales: Asteraceae) in the US, grossing approximately $178 million per year. In South Dakota, both confection and oilseed sunflower cultivars are grown. Despite breeding efforts to increase sunflower's ability to self-pollinate there is evidence that pollinator visitation results in increased sunflower yields. In addition, there is evidence that sunflower pollen is beneficial for pathogen resistance in various bee species, suggesting the importance of a mutualistic relationship between pollinators and sunflowers. In some areas, observed increases in sunflower yield is attributed to the presence of Apis …
The Role Of A Community Coach In Rural Food Councils In Six Midwestern States, Kaitlyn Tusha
The Role Of A Community Coach In Rural Food Councils In Six Midwestern States, Kaitlyn Tusha
Electronic Theses and Dissertations
Objective: To quantitatively assess perceived coaching confidence of a community coach working with food councils, and to qualitatively determine perceived barriers and facilitators associated with coaching rural food councils.
Design: Two phases were implemented using a mixed methods study design with quantitative (scorecard) and qualitative (key informant interviews) methodologies.
Setting: Six rural, Midwestern states implementing Voices for Food.
Participants: Voices for Food community coaches (n=9) who coached rural food council(s).
Intervention: A component of the broader Voices for Food intervention.
Analysis: Quantitative scorecard data were analyzed with STATA by running paired ttests. Qualitative key information interview data were analyzed with …
The Relationship Between Campus Wellness Center Usage And Symptoms Of Depression In College Freshmen, Allison Leonard
The Relationship Between Campus Wellness Center Usage And Symptoms Of Depression In College Freshmen, Allison Leonard
Electronic Theses and Dissertations
There is limited research done on the relationship between the program utilization at a campus wellness facility and the symptoms of depression in college freshmen. College students have been found to have a higher prevalence of depressive symptoms than the general population, possibly due to the stressors college life can add. Studies have been done on the effects of physical activity as an intervention for depression as well as on the benefits of campus wellness facilities; however, there have been few studies that look at both campus recreation and depression. The author’s purpose for this study was to see if …
Evaluation Of Effects Of Methods Used For Forage Analysis And Dietary Inclusion Of Buffer On Fiber Digestibility And Rumen Fermentation In Diets High In Distillers Grains, Lydia Kehinde Olagunju
Evaluation Of Effects Of Methods Used For Forage Analysis And Dietary Inclusion Of Buffer On Fiber Digestibility And Rumen Fermentation In Diets High In Distillers Grains, Lydia Kehinde Olagunju
Electronic Theses and Dissertations
Forage quality is an important factor affecting intake and utilization of forage, thus making it imperative to evaluate the methods used to determine the nutritive values of forage in order to predict animal performance. Additionally, fibrous feeds for ruminants are less subject to competitive demand. The plant cell wall is the largest hindrance to complete digestion of feeds, particularly forages and by-products and to the utilization of the nutrients and energy they contain, necessitating effective strategies for increasing the rate and efficiency of utilization of forage fiber and the energy therein. It is critically important to increase fiber digestion for …
The Impact Of Alcohol Consumption On Academic Success And Athletic Identity In Collegiate Student-Athletes, Zoe E. Arnold
The Impact Of Alcohol Consumption On Academic Success And Athletic Identity In Collegiate Student-Athletes, Zoe E. Arnold
Electronic Theses and Dissertations
Upon entering college in the United States, students are exposed to alcohol and, relatedly, the potentially dangerous experiences and effects that come with consuming alcohol. This is especially true for collegiate student-athletes, who have been found to have the highest consumption rate among student groups on campus. The purpose of the study was to understand the relationship between how student-athletes at a focus university, a Division I member of the National Collegiate Athletic Association, experience alcohol consumption, how their consumption affects their academic grade point average (GPA), and how athletic identity plays a role in their experiences. While the research …
Evaluation Of Flax Oil Supplementation On Performance Of Growing Dairy Heifer Calves And Lactating Cows, Chelsea Rose Schossow
Evaluation Of Flax Oil Supplementation On Performance Of Growing Dairy Heifer Calves And Lactating Cows, Chelsea Rose Schossow
Electronic Theses and Dissertations
Utilization of flax oil is new to the livestock industry, and limited research has been done to see the benefits of feeding the highly unsaturated oil to both dairy calves and lactating cows. Two studies were conducted to evaluate the potential benefits of flax oil as a lipid supplement. The first study compared the supplementation of two plant based oils to growing dairy calves. Thirty-six female Holstein calves in individual hutches were used in a 12-wk randomized complete block design study. Treatments were: 1) control (CON) with no oil, 2) 80 g/d of flax oil (FLAX), and 3) and 80 …
Cropping Sequence Affects Subsequent Soybean Yield, Soil Microbiome And Soil Health, Izzet Bulbul
Cropping Sequence Affects Subsequent Soybean Yield, Soil Microbiome And Soil Health, Izzet Bulbul
Electronic Theses and Dissertations
Rotation is an important cultural practice that farmers use to manage crop growth and diseases. Diversified crop rotations directly affect plant residue inputs that may enrich specific groups of microbes that form beneficial associations with the following crop. At two field sites, yield differences were observed in soybeans planted after the following four long-term (14 year) crop sequences: continuous corn (CC), corn (Zea mays)/corn/soybean (Glycine max) (CCS), corn/soybean/corn (CSC), soybean/corn/soybean (SCS). Soybean yields were in decreasing order, CC>CCS>CSC>SCS, and the yield differences could not be explained by soil chemical and physical properties previously …
A Comparison Between The Efficacy Of Traditional Periodization, Undulating Periodization, And Plyometric Training And Their Lasting Effects On Performance Outcomes In Youth Athletes. A Systematic Review And Meta-Analysis, Andre Mcintyre
Electronic Theses and Dissertations
Recreational and competitive youth (≤ 16 years old) sport participation over the years has increased in recent years. As a result of increased sport participation an emphasis on sport performance training and more particularly resistance training along with plyometric training have been on the rise. Resistance training and plyometric training can improve sports performance, rehabilitate injuries, prevent injuries, and enhance long-term health in adolescent athletes. Resistance training can be periodized numerous different ways, but the most popular training methods are traditional periodization, undulating periodization, and plyometric training. This systematic review and meta-analysis examined studies that compared traditional periodization, undulating periodization, …
Relationship Of Weight-Related Eating Behaviors And Weight-Loss Of Participants In A Proprietary Weight-Loss Program, Megan Tschakert
Relationship Of Weight-Related Eating Behaviors And Weight-Loss Of Participants In A Proprietary Weight-Loss Program, Megan Tschakert
Electronic Theses and Dissertations
The aim of this study is to evaluate weight-related eating behaviors of participants with clinically significant weight loss (CSWL) in a proprietary weight loss program. A crosssectional sample of participants (n=1,454) enrolled in a proprietary weight-loss program that includes meal replacements and health coaching were queried for weight-related eating behaviors (using Weight Related Eating Questionnaire) of routine restraint (RR), compensatory restraint (CR), susceptibility to external cues (SEC), and emotional eating (EE) in relation to CSWL (defined as having achieved a weight loss greater than 10% of starting weight). Participants were dichotomized into those with CSWL (n=973) and with no CSWL …
Maximizing Ecosystem Services Provided To The New Oil Crop Brassica Carinata Through Landscape And Arthropod Diversity, Shane Stiles
Maximizing Ecosystem Services Provided To The New Oil Crop Brassica Carinata Through Landscape And Arthropod Diversity, Shane Stiles
Electronic Theses and Dissertations
Prairies, once spanning the Upper Midwest, have now largely been replaced by agriculture. The lack of resources available to pollinators in agricultural fields and the practices employed by farmers to maximize yield has led to a decline in insect and pollinator diversity. There is a need to better understand how ecosystem services provided by a diverse insect community scale to current farming practices as they relate to crop yield. We sought to explain how landscape heterogeneity relates to insect and pollinator diversity, as well as how insect diversity relates to crop yield across common farming practices. To evaluate how farming …
Using Maximum Power As A Variable For 1rm Prediction In The Squat And Bench Press, Sean O'Connor
Using Maximum Power As A Variable For 1rm Prediction In The Squat And Bench Press, Sean O'Connor
Electronic Theses and Dissertations
Many Strength and Conditioning (S&C) coaches utilize a one-rep max (1RM) exercise test to gauge the maximal strength of athletes, and then prescribe resistance training programs based on a relative percentage of 1RM to obtain strength or power adaptations. However, many S&C coaches have raised questions regarding the safety and necessity of a 1RM test. Attempts to mitigate the weaknesses of 1RM testing have led to other methods of testing including repetition max testing (3RM, 5RM, 10RM, etc.) as well as load/velocity profiling. The main purpose of this study is to determine if 1RM can be accurately estimated from maximal …
African American Student-Athletes: Factors Influencing Choice Of Graduate School, Tanner Feterl
African American Student-Athletes: Factors Influencing Choice Of Graduate School, Tanner Feterl
Electronic Theses and Dissertations
Although support systems are in place for student-athletes, African Americans remain underrepresented in careers requiring a graduate education, including intercollegiate athletic departments (Okahana, Feaster, & Allum, 2016). The purpose of this qualitative, phenomenological study was to explore the factors influencing an NCAA Mid-major, Division I African American student-athletes’ choice of pursuing graduate school. Researchers identified themes utilizing Critical Race Theory (CRT) and Student Involvement Theory frameworks to explain the influencing factors. The participants consisted of nine African American sophomore, junior, and senior student-athletes who participated in different sports and were chosen using purpose sampling. Each participant took part in an …
Quality Evaluations Of Hard Red Spring Wheat Grown In South Dakota, Lance Merrick
Quality Evaluations Of Hard Red Spring Wheat Grown In South Dakota, Lance Merrick
Electronic Theses and Dissertations
Hard Red Spring Wheat (HRSW; Triticum aestivum L.) is characterized by generally high protein content and excellent baking and milling performance. The ability for millers, bakers, and other end-users of wheat to properly and cheaply produce food products with uniformity is dependent on the quality consistency of wheat produced by breeders and farmers. Determining how production years and locations influenced enduse quality traits will assist breeders, agronomists, and growers, in understanding which hard red spring wheat (HRSW; Triticum aestivum L.) varieties are least susceptible to quality fluctuations, and therefore, most desirable to end-users. In order to determine which varieties were …
Cross-Sectional And Longitudinal Effects Of Glycemic Status On Body Composition, Bone, And Lipid Profile In Men Aged 20 To 66 Years: A Population-Based Study, Khaleal Almusaylim
Cross-Sectional And Longitudinal Effects Of Glycemic Status On Body Composition, Bone, And Lipid Profile In Men Aged 20 To 66 Years: A Population-Based Study, Khaleal Almusaylim
Electronic Theses and Dissertations
Pre-diabetes and type 2 diabetes (T2D) are significant public health challenges in the United States. Pre-diabetes and T2D are a multi-factorial disease characterized by genetic or environmental factors or a combination of both. There has been an upward trend over time in the prevalence of both pre-diabetes and T2D. Few epidemiological studies exist regarding the effect of baseline glycemic status on changes in body composition, bone health, and lipid profiles. To fill this critical gap, the purpose of this research was to examine both cross-sectional and longitudinal changes in glycemic status with changes in body composition, bone mass and density, …
Anabolic Hormone Exposure During Various Stages Of Growth: Effects On Post-Weaning Performance, Frame Size, And Carcass Characteristics Of Calf-Fed Steers, Wesley W. Gentry
Anabolic Hormone Exposure During Various Stages Of Growth: Effects On Post-Weaning Performance, Frame Size, And Carcass Characteristics Of Calf-Fed Steers, Wesley W. Gentry
Electronic Theses and Dissertations
The growth promoting activity of implants have been documented. However, stage of growth in which the implant is administered may alter growth performance and carcass traits. An experiment was conducted to examine the effects of administering a conventional implant (Synovex C; SYN-C), or an extended-release combination implant (Synovex One Grass; ONE-G) to suckling steer calves on weaning weight, post-weaning growth performance, and carcass characteristics. Suckling steer calves were either not implanted (NONE) or were implanted with SYN-C or ONE-G. Steer calves were predominantly 30 to 60 d of age when implants were administered. Steers were weaned 176 d post-suckling implant …
The Efficacy Of Protein Supplementation On Attenuating Muscle Atrophy Following Disuse In The Collegiate Population, Leah Kroeger
The Efficacy Of Protein Supplementation On Attenuating Muscle Atrophy Following Disuse In The Collegiate Population, Leah Kroeger
Electronic Theses and Dissertations
The purpose of this study is to determine the effects of a protein supplementation protocol through a period of muscular disuse in maintaining muscle mass, strength, jump force production, and cross-sectional area in the collegiate population. Two groups of healthy collegiate participants underwent two weeks of unilateral lower limb suspension (ULLS), during which the control group consumed a normal diet and the treatment group received an additional 75 g of protein supplementation. Lean mass, strength, and force production were measured between dietary intakes at baseline and following immobilization. Muscle area was lost between both groups following ULLS (treatment, - 282.8 …
Effects Of Oats And Distiller’S Dried Grains Fibers On Fortification Of Asian Noodles – Evaluation Of Glycemic Response, Noodle Quality And Nutritional Composition, Kara Konst
Electronic Theses and Dissertations
The objective of this study was to develop Asian wheat noodle formulations enriched with oat flour and corn DDG at 10, 20 and 30 % wheat flour replacement levels and to evaluate the effects of this fiber and protein enrichment on the glycemic response of human subjects. We hypothesized that the addition of high-fiber oats and high-fiber, high-protein DDG will have synergistic effects in lowering the glycemic response in human subjects. In this study, steamed instant Asian noodles were prepared with DDG(D) and oats(OF) in combination with all-purpose wheat flour(W) in the following flour blends: (W:D) 90:10, (W:OF) 90:10, (W:D) …
Effect Of Mineral Ions On The Functional Properties Of Starch Films, Aliza Sigdel
Effect Of Mineral Ions On The Functional Properties Of Starch Films, Aliza Sigdel
Electronic Theses and Dissertations
Essential minerals are indispensable inorganic micronutrients that modulate vital physiological functions at the molecular level. Their deficiency, though required in small amounts, impairs health significantly. Their supplementation through diet is prudent and carbohydrates standout as favorable choice. Carbohydrates, starches and polysaccharides, exhibit unique chemical structures and functionalities, and interact with mineral ions in several ways. The aim of this research is to investigate the effect of mineral ions on the physicochemical properties, tensile strength and in vitro starch digestion of starch-films. Corn starch and potato starch along with Fe2+, Mn2+, Cu2+ and Zn2+ ions have been chosen as model starch …
Menstrual Cycle And The Vascular Properties Of Remote Preconditioning, Shelby Rachel
Menstrual Cycle And The Vascular Properties Of Remote Preconditioning, Shelby Rachel
Electronic Theses and Dissertations
PURPOSE: A promising therapeutic intervention to counteract endothelial ischemia/reperfusion (I/R) injury is ischemic preconditioning (IPC). Limited data from ovariectomized animal models shows that estrogen deficiency abolishes the cardioprotective effects of IPC, whereas estrogen replacement restores protection. This suggests that alterations in female sex hormones, particularly estrogens, that occur naturally during the menstrual cycle is likely to influence the vascular protective properties of IPC. The aim of the present study was to identify how changes in female sex hormones that occur naturally during the menstrual cycle interfere with IPC to provide vascular endothelial protection in women. METHODS: Nine healthy premenopausal eumenorrheic …
Level Of Satisfaction Among Food Pantry Clients, Staff/Volunteers, And Directors And Its Association With Client Choice In Food Pantry Layouts, Myranda Dunmire
Level Of Satisfaction Among Food Pantry Clients, Staff/Volunteers, And Directors And Its Association With Client Choice In Food Pantry Layouts, Myranda Dunmire
Electronic Theses and Dissertations
Objectives: Food insecurity is an issue in rural communities, particularly among food pantry clients. Food pantries may not provide clients with the opportunity to choose their own foods (client choice), and instead may just give a set amount and type of foods. Client choice is important in regards to client health status as well as perceptions of autonomy and quality of life. Although client choice can be promoted in food pantries, it may be difficult to grasp the process of food pantry transitioning and how well changes such as these may be perceived by clients or food pantry personnel. We …
Developing Zebrafish As An In Vivo Model To Screen Compounds For Anti-Cancer Activity In Human Breast Cancer, Trisha Dhawan
Developing Zebrafish As An In Vivo Model To Screen Compounds For Anti-Cancer Activity In Human Breast Cancer, Trisha Dhawan
Electronic Theses and Dissertations
Breast Cancer (BC) is the most frequently diagnosed cancer; 1:8 women are at risk of developing BC in her lifetime. Cancer metastasis causes the majority of deaths in BC patients. Moreover, side effects of traditional chemotherapeutic drugs (TCD) impair the quality of life of these patients. Discovery and development of safe and effective new therapies is imperative for the treatment of BC and targeting metastasis. The goal herein is to further expand the applicability of in vivo xenotransplantation of human BC cells in transgenic zebrafish to screen potential chemotherapeutics for toxicity and efficacy. For xenotransplantation, MCF-7, BT-474, and MDA-MB-231 BC …
Weight Teasing Among Obese Youth: Social Functioning Outcomes Following A Pediatric Weight Management Intervention, Joseph Mitchell Magness
Weight Teasing Among Obese Youth: Social Functioning Outcomes Following A Pediatric Weight Management Intervention, Joseph Mitchell Magness
Electronic Theses and Dissertations
The prevalence of excess weight and obesity among children and adolescents in the United States continues to increase. Aside from the different effects weight has on a person’s physical and psychological well-being, obese youth often experience poorer social functioning than normal weight peers. Weight teasing is among those highlighted social difficulties. Pediatric weight management program interventions have been shown to improve health-related quality of life (HRQoL) across domains for obese youth. However, few studies have examined the impact of weight management interventions on social quality of life for those with a history of weight teasing. The present study aimed to …