Digital Commons Network^™

Dinitroxides In Rapid Scan Electron Paramagnetic Resonance Imaging, Lukas B. Woodcock

Electronic Theses and Dissertations

Local tissue physiology is an important parameter in understanding disease behavior. Rapid Scan (RS) electron paramagnetic resonance (EPR) offers a unique, non-invasive tool for investigation of these so-called microenvironments through EPR Imaging (EPRI). Research into advancement of EPRI falls into many categories. Not least among those are advances in instrumentation and methodology. Presented here are updates to a benchtop EPRI instrument operating at 1 GHz targeted at pre-clinical EPRI applications. Newly developed methods for reducing RS-EPR background through inversion of the magnetic field are also demonstrated. EPR applications are limited in native biological systems due to the miniscule concentration of …

An Existential Punchline: How Humor Functions In A Young Adult Friendship Facing Advanced Cancer, Megan E. Solberg

Electronic Theses and Dissertations

Young adults (i.e., age 18-39) only comprise 4% of the total cancer population, yet cancers in this group are commonly found at more advanced stages due to situational factors influencing delayed diagnosis including access to healthcare, quality health insurance and competing life demands that may hinder prioritization of healthcare. Young adults with cancer also face unique challenges including higher rates of psychological distress, which may contribute to increased risk of social disconnection in response to cancer. Research suggests that humor may be a helpful coping approach and communication mechanism for mitigating distress and discussing difficult topics. Grounded within the frameworks …

Counselors’ Spirituality, Attitudes Toward Suicide, And Self-Efficacy In Conducting Suicide Risk Assessment, Tayler Hendrix

Electronic Theses and Dissertations

The present study aimed to explore the relationship between perceived spiritual support and counselor self-efficacy in conducting suicide risk assessment, and the moderating effects of attitudes about suicide on this relationship. Based on existing theory and empirical evidence, perceived spiritual support was hypothesized to have a positive predictive relationship with counselor self-efficacy in performing suicide risk assessment; further, four different constructs pertaining to attitudes toward suicide were also hypothesized to moderate the strength and direction of this relationship. A sample of Master’s level clinicians and advanced standing Master’s graduate students (N=132) completed on online survey containing instruments measuring perceived spiritual …

Teaching On The Möbius: Exploring The Inner And Outer Landscapes Of Teacher Practice, Barth A. Quenzer

Electronic Theses and Dissertations

The practice of teaching takes on renewed significance in today’s changing educational landscape. In the quest for transformative teaching and learning, there are both familiar and unfamiliar paths to be traversed. While significant contributions are being made by culturally responsive pedagogies, less is understood about the inner life of teachers as they navigate the outer systems of their practice. To address this area of research opportunity, the author used the conceptual framework of humanizing pedagogy and deep pedagogy to explore the inner and outer landscapes of teacher practice. As a method of inquiry, educational criticism afforded a qualitative approach for …

Older Women’S Stories Of Covid-19 Loss: Communicated Narrative Sense-Making Through Photography, Anne Walker

Electronic Theses and Dissertations

The diverse array of challenges associated with the COVID-19 pandemic make it difficult to assess the full impact of this global health crisis. More than 300,000 older Americans died, leaving a nation of grieving survivors in their absence. This profound loss of life will undoubtedly inform the field’s understanding of grief and grieving for many years to come. Pre-pandemic, older women in the United States understood grief to be part of their life stage; COVID-19 amplified the grief experience through both cumulative losses and the isolation particular to the novel coronavirus response. However, few qualitative studies explore older women’s grief, …

Controllable Language Generation Using Deep Learning, Rohola Zandie

Electronic Theses and Dissertations

The advent of deep neural networks has sparked a revolution in Artificial Intelligence (AI), notably with the creation of Transformer models like GPT-X and ChatGPT. These models have surpassed previous methods in various Natural Language Processing (NLP) tasks. As the NLP field evolves, there is a need to further understand and question the capabilities of these models. Text generation, a crucial part of NLP, remains an area where our comprehension is limited while being critical in research.

This dissertation focuses on the challenging problem of controlling the general behaviors of language models such as sentiment, topical focus, and logical reasoning. …

The Treasury Of Stories: Policy Narratives Of Anti-Illicit Finance, Paul Christopher Kemp

Electronic Theses and Dissertations

This dissertation explores how the US government identifies and responds to the problem of illicit finance, specifically, why the US Treasury utilizes certain approaches over others. I employ a comparative case study of three relatively recent, non-traditional approaches in the Treasury’s anti-illicit finance repertoire: targeted financial sanctions (a case of strong policy action), anti-money laundering in real estate (a case of tentative policy action), and the proposed demonetization of high denomination notes (a case of policy inaction). While considering a wide range of plausible explanations for this variation in policy action, I argue that the Treasury’s decision to either …

Historical Narrative In The Music Of Sid Meier’S Civilization Vi, Alec Larner

Electronic Theses and Dissertations

Sid Meier’s Civilization VI is a 2016 strategy video game in which the player leads a historical civilization from 4000 BC to the present. The Civilization series is the subject of much scholarly writing, especially its representation of history and non- Western cultures. My work builds on Karen Cook’s research (2014) on the technological progress and American hegemonic identity signaled by Civilization IV’s soundtrack. I argue that the music in Civilization VI contributes to a Eurocentric teleological progress narrative of history inherent in the structure of the game: the idea that history is a story of inevitable and positive …

Risky Behavior As Motivated Emotion Regulation: A Mixed-Method Approach, Lyneé A. Herrera

Electronic Theses and Dissertations

Engaging in risky health behaviors is a ubiquitous human experience that often marks developmental progression from adolescence into adulthood. While much previous research has framed risky behaviors in terms of negative legal, social, and public health consequences, less empirical work has been done on potential benefits of their engagement. A growing body of research has identified emotion regulation deficits as a significant driver of risky behavior engagement, suggesting that these behaviors may offer perceived emotional benefits when other regulation strategies are less accessible. Previous research has shown that emotional outcomes can be influenced by the regulation strategies one chooses to …

The Gender And Race Intersectional Disproportionality-Tool (Grid-T): An Exploration Of Practitioners’ Access To And Use Of High-Quality Data For Special Education Placement, Audrey J. Ford

Electronic Theses and Dissertations

Disproportionality in special education (SPED) is upheld by systems and individuals, policies, and practices that both reflect and shape the local communities within which it exists. Even with many proposed solutions for disproportionality, it persists. This two-manuscript dissertation explores two characteristics that make disproportionality difficult to solve (e.g., inconsistent findings and persistence) and proposes a tool to inform data-based decision making in interventions for disproportionality in SPED.

Manuscript One (M1) includes a literature review and development of the Gender and Race Intersectionality Disproportionality- Tool (GRID-T). Based on the findings of the literature review about inconsistence and persistence, I crafted three …

Understanding Associations Between Chronic Illness Identity, Psychological Flexibility, And Type 2 Diabetes Emotional, Behavioral, And Psychosocial Functioning., Valery Bodziony

Electronic Theses and Dissertations

Introduction: Illness identity, defined as the extent to which one integrates their illness into their sense of self, may be a key psychological factor to consider in overall adjustment to and management of Type 2 Diabetes. Emerging research suggests illness identity integration is associated with aspects of diabetes-specific functioning. Psychological flexibility has also been found to be associated with positive diabetes-specific functioning. This modifiable cognitive factor may play a role in the relationship between illness identity and diabetes-specific functioning. This study aims to examine associations between illness identity enrichment, illness identity rejection, psychological flexibility, and aspects of diabetes-functioning, including self-management …

Institutional Racism, Racial Trauma, And Mental Health In Bipoc Graduate Students And Professionals., Jody Zhong

Electronic Theses and Dissertations

While there is increasing mainstream focus on diversity, equity, and inclusion (DEI) amongst U.S. college campuses, institutional racism and everyday racist events continue to be common experiences for Black/Brown, Indigenous, and People of Color (BIPOC) students (Bartz, 2019; Noltemeyer et al., 2012; Pieterse et al., 2010; Regis, 2016; Vaishnav, 2020). Research has shown that subtle, everyday racist slights, known as microaggressions, can have a substantial effect on the mental health and functioning of BIPOC, leading to the development of posttraumatic stress and to negative impacts on psychological well-being (Abdullah et al., 2021; Le et al., 2021; Lui & Quezada, 2019; …

“Long Live Ear X-Tacy!”: An Oral History Study Of Rhetorics Of Nostalgia And Place., Aubrie Warner

Electronic Theses and Dissertations

This study aims to explore rhetorical placemaking through how people understand and construct narratives around places that no longer exist. In doing so, it examines the relationship between nostalgia and place — how rhetorical construction of place is influenced and/or informed by rhetorics of nostalgia, how our experiences influence our sense of place (past and present), and how we create continuity for ourselves in the construction and maintenance of particular narratives. This study contributes to the emerging field of rhetorics of nostalgia and places it in direct conversation with rhetorics of place and unpacks how these two are more connected …

Where Are All The Women?: Using Role Congruity Theory To Explore The Experiences Of Female Interscholastic Athletic Directors., Nicholas Swim

Electronic Theses and Dissertations

Leadership in sport organizations continues to be male dominated, even as multiple scholars have argued and proven the importance of women holding sport leadership positions (Burton & Leberman, 2017; Darvin & Lubke, 2021; Schull, 2017). The lack of women attaining these positions leads to fewer opportunities for role modeling and mentoring experiences for female athletes. As Burden et al. (2010) argue, interscholastic athletic directors are important as they usually represent the first interactions for young athletes with people in sport leadership positions. Researchers have investigated this phenomenon at the intercollegiate level (Bower & Hums, 2013; Darvin & Lubke, 2021; Taylor …

Novel Breath Collection Techniques For Detection Of Covid-19., James Morris

Electronic Theses and Dissertations

Volatile Organic Compounds (VOC) generated endogenously in the human body can be used to detect diseases that induce oxidative stress and inflammation. Breath analysis has been used for the detection of diseases such as COPD, Depression, Lung Cancer and most recently COVID-19. Methods such as Exhaled Breath Condensate (EBC), Sorbent Tubes, Solid Phase Microextraction (SPME), and silicon microreactors have shown considerable capability in extracting and concentrating trace VOC’s present in human breath. Silicon microreactors functionalized with capture agents to derivatize carbonyl compounds are effective but the overall maximum flow rate of breath sample possible during analysis is low, making direct …

The Relationships Between State-Level Economic Policies, Child Maltreatment, And Suicidal Behavior And Mortality., Yana B. Feygin

Electronic Theses and Dissertations

Suicide has proven to be difficult to predict and prevent at the individual level,1–3 so much so that a recent analysis of individual risk assessments found a maximal positive predictive value of 5.5% for suicide death,2 and suicide continues to be a leading cause of death among adolescents age 10-19 years.4 By targeting modifiable risk factors at the population level, policy has the potential to extend our reach to people and subgroups that are missed by individual level interventions. This ecological study of adolescent suicide rates, state policies, and child maltreatment in US states from 2005-2019 and Kentucky counties from …

Aurka Inhibition-Based Combination Therapy Approaches In Glioblastoma., Muge Sak

Electronic Theses and Dissertations

Glioblastoma is the most common and aggressive central nervous system tumor in adults with a 6% survival rate. Decades of research for improving life expectancy and quality of life have been ineffective. The discovery of better treatment strategies is urgent to improve the survival rates for glioblastoma patients. Aurora Kinase A is a regulator of tumor progression and is overexpressed in glioblastoma. We used a specific Aurora Kinase A inhibitor alisertib in combination with DNA-damaging platinum agent carboplatin or brain-penetrating taxane TPI 287. We investigated the efficacy of these combinations in treating in vitro and in vivo tissue culture models …

Kdm5b As A Potential Epigenetic Regulator Of Cardiomyocyte Regeneration And Cell Cycle Activation., Dana Hammouri

Electronic Theses and Dissertations

The limited regenerative capacity of adult cardiomyocytes (CMs) is manifested in prevalent morbidity and mortality associated with ischemic heart disease. We previously demonstrated that a combination of four cell cycle factors (4F) promotes efficient cell division in differentiated CMs. The temporal transcriptional reprogramming in the 4F-transduced CMs indicates that epigenetic modifications mediate the cell cycle progression. Through small molecule screening, we evaluated the epigenetic impact on CM’s response in the 4F-transduced CMs. We identified the histone demethylase 5B (KDM5B), which through in vitro and ex vivo genetic knockdown and overexpression studies, exhibited a modulative effect on CM’s cell cycle plasticity …

Illuminating Underappreciated Mechanisms Of Receptor Regulation In Human Lymphocytes., Cassandra Woolley

Electronic Theses and Dissertations

A thorough understanding of receptor regulation is imperative to predict expression in varying contexts of disease or treatment. Lymphocyte surface receptors are often used as biomarkers and drug targets, making them particularly important for study. For receptors of debated functionality, such as the Fc receptor for IgM (FcMR), understanding regulation can also help to predict expression in vivo to supplement hypotheses of biological roles. Various mechanisms exist for altering receptor surface expression, including direct feedback mechanisms such as ligand-induced endocytosis and broader mechanisms such as transcriptional and translational control. In this dissertation, we explore selected underappreciated mechanisms of lymphocyte receptor …

Perceptions Of Preparedness Regarding Administrative Responsibilities: A Comparative Analysis Of Preservice And In-Service Secondary Music Educators., Ashley Ann Hokenson

Electronic Theses and Dissertations

This study investigated perceptions of knowledge and preparation regarding administrative responsibilities among in-service and preservice music teachers. Samples were selected randomly through NAfME and NASM databases. Data collection and analysis answered research questions asking how knowledgeable these groups felt about administrative topics, how they felt their undergraduate coursework prepared them for administrative responsibilities, and if there were any significant differences in preparedness among different subject areas taught by in-service directors. The findings report in-service teachers felt more knowledgeable of all administrative topics. Among in-service and preservice teachers, one significant difference was found; regarding preparedness pertaining to laws of communication via …

Promotional Communication For A College Food Pantry: Findings From A Cross-Sectional Assessment Of Socioecological Variables Related To Past Use Of A Campus-Based Food Pantry., Bunny Marie Hayes

Electronic Theses and Dissertations

Objective: This study examined differences between users and non-users of campus food pantry, conducted communication audit, and made recommendations for future food pantry communication. Methods: Cross-sectional twofold study, first analyzing existing intrapersonal, interpersonal, and environmental data to test predictors of campus food pantry usage characteristics, using inferential statistics. Secondly, conducting a communication audit that evaluates the reach of student communication. Results: Significant differences were found between users and non-users of food pantry that support hypotheses in relation to gender, age, race, class, marital status, housing type, housing description, and Pell eligibility. Findings could not support hypothesized differences in first-generation status. …

Novel Insights Into Oligodendrocyte Biology From Developmental Myelination Studies In Autophagy Deficient Mice And Analysis Of Oligodendrocyte Translatome Response To Contusive Spinal Cord Injury., Michael David Forston

Electronic Theses and Dissertations

Loss of myelin causes severe neurological disorders and functional deficits in white matter injuries (WMI) such as traumatic spinal cord injury (SCI). This dissertation is focused on autophagy in OL development and the OL translatome after SCI. Chapter I describes the history of myelin, OL development, and their involvement in neurodegenerative diseases and SCI. The proteostasis network, in particular autophagy, and its contributions to white matter pathology is discussed. It concludes examining advantages and disadvantages of unbiased omics tools, like RiboTag, to study transcriptional/translational landscapes after SCI. Chapter II focuses on autophagy in OPC/OL differentiation, survival, and proper myelination in …

Connectivity Of Amygdala Somatostatin-Expressing Neurons And Their Role In Taste-Guided Behavior., Jane Jeruto Bartonjo

Electronic Theses and Dissertations

The nucleus of solitary tract (NST) and parabrachial nucleus (PBN) represent the first and second central synapses of ascending gustatory information. Neural processing in these nuclei is influenced by descending input from forebrain regions such as the central nucleus of the amygdala (CeA). In mice, we have shown that somatostatin (Sst) expressing neurons of CeA that project to NST and PBN are largely distinct cell populations and optogenetic inhibition of the CeA/Sst-to-NST subpopulation increases the intake of high concentrations of quinine with no apparent effect on sucrose intake. Synaptic connectivity of these cells is needed to understand the possible mechanisms …

Fbg Αc 389 – 402 Modulates Factor Xiii Crosslinking In The Fibrinogen Αc Region., Francis Dean Orlina Ablan

Electronic Theses and Dissertations

Fibrinogen (Fbg) is a coagulation protein critical for clot formation. Coagulation Factor XIII (FXIII) is a calcium-dependent transglutaminase that crosslinks reactive glutamines (Q) and lysines (K) between fibrin and other anti-fibrinolytic proteins. In the presence of Ca²⁺, FXIII could be activated non-proteolytically (FXIII-A°), or proteolytically by thrombin (FXIII-A*). Significant increases in clot stability and red blood cell retention are linked to FXIII activity in the fibrinogen αC region (Fbg Aα 221 – 610). This region contains several FXIII-reactive glutamines and lysines, as well as a binding site for FXIII-A* (Fbg αC 389 – 402) that includes a key …

Perception Is Reality! How Perception Shapes Our World., Nicole Clay

Electronic Theses and Dissertations

This thesis is an examination of the role different photography techniques play in how images are perceived. There have existed techniques for manipulating the perception of images since the creation of the camera. The techniques examined in this paper are editing, staging, and the use of captions. In recent years, perception has become a powerful tool for political parties to manipulate. This manipulation of perception has led to an increasing distrust in the images the media presents to the public. This paper does not seek to answer any questions but to encourage people to have a greater understanding of photography.

Sense Of Belonging For Black Families At Their Child's School: Factors That Promote, Inhibit, And Oppress., Jill Handley

Electronic Theses and Dissertations

The purpose of this qualitative study was to investigate how the perceptions about family engagement structures influence the sense of belonging for Black families at their child’s school. Qualitative participatory action research (PAR) design was used for this study and purposeful homogenous sampling (Creswell, 2012) was used to select participants. The participants for this study were Black parents/guardians of students in grades K-12 in Jefferson County, Kentucky. This qualitative study used the World Café method to collect multiple data points that were triangulated to contribute to the trustworthiness of the study (Glesne, 2006). Epstein’s Model of Overlapping Spheres and Bourdieu’s …

Non-Western Rendition Of Ambient Rhetoric Of Khajuraho Monuments., Shiva Hari Mainaly

Electronic Theses and Dissertations

This dissertation develops an ambient rhetoric: a living practice that is more disclosive than communicative, more entangled than intersectional, and more subtle than explicit and evidential. Rather than exploring the symbology, iconography, texture, and artistic integrity of Khajuraho monuments, I claim that Khajuraho monuments aim at convincing visitors with their persuadability and affectability inherent in their material bases, architectural panels, fractal design, allegorical cast, aura of attunement, and the environment in which the monument complex is nestled. Khajuraho groups of monuments in Central India, matchless in their monumentality, dynamic in their adjustment to the shifting socio-politico-cultural landscape in the world, …

New Methodologies For Sustainable Organic Synthesis In Water., Sudripet Sharma

Electronic Theses and Dissertations

Water is stable, benign, and green solvent. Its usage as a solvent in organic synthesis is significantly enhanced by micellar catalysis. However, replacing water as a reaction medium in organic synthesis is not sufficient to meet the sustainability challenges—excessive organic solvents are still required for product isolation and purification. Notably, solvents used in syntheses contribute to more than 80% of waste generation. In addition to solvents, the use of palladium in large amounts is also a problem for the future as it is a precious, low-abundance metal, and its supply is dwindling. Therefore, this dissertation highlights the various sustainable protocols …

Exploring The Lived Experiences Of Dysphoric Milk Ejection Reflex During Postpartum Breastfeeding: A Phenomenological Study, Stephanie Herr, Jessica Devido, Richard Zoucha, Jill Demirci

Electronic Theses and Dissertations

This study sought to explore the lived experiences of Dysphoric Milk Ejection Reflex (D-MER) during postpartum breastfeeding. A phenomenological method based on Giorgi’s phenomenological underpinnings was used. The setting for this study was virtual interviews in a secure online platform. The sample consisted of 13 participants, self-identifying as experiencing D-MER. Semi-structured interviews, with thematic analysis of transcription were conducted. Four major themes were identified: 1) Breastfeeding concessions and toleration; 2) Something does not feel “normal”; 3) I remember a feeling like this before 4) This is real, and recognition is validating. Conclusions were that women of this study value the …

A Qualitative Content Analysis Of Nigerian Popular Music Genres: A Culture And Heritage Approach To Nation Branding, Cecilia Ashibel

Electronic Theses and Dissertations

This thesis explores the potential of Nigerian popular music as an approach to nation branding. The study employs qualitative content analysis to analyze select Nigerian music genres to examine how Nigeria is portrayed to international audiences and the economic benefits that can be derived from this form of branding. The analysis focuses on narrative themes of “the value of hard work,” “ethnic pride,” “lavish lifestyle,” and the impact of differences which were derived from the data. Findings indicate that Nigeria is globally reckoned for its musical prowess and rich cultural heritage. In highlighting the role of music in Nigeria’s political …