Digital Commons Network^™

Enzymatic Depletion Of Adenosine To Potentiate Cancer Immunotherapy., Omar Sadi Sarkar

Electronic Theses and Dissertations

Immune checkpoint blockade (ICB) therapies have revolutionized cancer treatment, but many patients still do not respond well. To improve therapeutic outcomes, chemotherapy is often combined with immunotherapy, as chemotherapy is known to promote immunogenicity. However, many patients develop resistance to this combination therapy, and the reasons behind it are not fully understood. In this study, we explored how platinum-based chemotherapy, specifically cisplatin, affects tumor signaling to create an immunosuppressive tumor microenvironment (TME). We found cisplatin triggers ataxia telangiectasia mutated (ATM)-mediated DNA damage signaling and induces higher expression of prostaglandin E₂ (PGE₂) via a cyclooxygenase-2 (COX-2) mediated pathway. We speculate DNA …

Experiences Of Title Ix Hearing Panel Members., Amanda Gage Stonecipher

Electronic Theses and Dissertations

The number of allegations of sexual misconduct on college campuses has been increasing over the past decade and higher education institutions are charged with addressing the misconduct. Addressing student behavior on college campuses through a conduct process is woven into the fabric of higher education, and many institutions use a hearing panel model to determine if institutional policies were violated. My research aims to explore how student conduct hearing panel members process the tension between the emotional management required when hearing intimate and traumatic details of a sexual misconduct case. The data for this research were collected via semi structured …

Characterizing The Ethanol Sensitivity Of The Planar Cell Polarity Pathway In Endoderm Morphogenesis And Jaw Development., Raéden Omneil C. C. Rolle Gray

Electronic Theses and Dissertations

Fetal Alcohol Spectrum Disorders (FASD) describes a large range of developmental defects due to prenatal alcohol exposure. It is characterized by neural and facial defects, including jaw hypoplasia. Many factors contribute to the susceptibility of ethanol-induced facial defects, including genetics, yet the genes involved, and the cell events they regulate, are poorly understood. Zebrafish have a large number of tools for genetic manipulation available, share 70% of genes with humans, are fertilized externally and are translucent during embryogenesis, making them great models to study FASD. Previous studies show that two members of the Planar Cell Polarity (PCP) pathway, zebrafish vangl2 …

Adoptive Parents Use Of Social Media To Discuss Adoption Communicative Openness, Hannah Araba Baidoo

Electronic Theses and Dissertations

Adoption communicative openness (ACO) involves dialogue between adoptive parents and their adopted children about adoption-related issues. Through this communication, parents share information about birth families and address adoptees questions to support psychological well-being. Although ACO benefits adoptees, research rarely examines how adoptive parents themselves practice and experience openness. This study explores how adoptive parents discuss ACO with one another on the r/AdoptiveParents subreddit. Using qualitative discourse analysis, it examines how parents describe their challenges, and success surrounding communication openness. The analysis highlights parent’s concerns about when and how to disclose adoption information and the uncertainty that shapes their communication choices. …

Postprocessing Gan-Generated Synthetic Time Series Using Dynamic Time Warping, Md Raisul Islam Roni

Electronic Theses and Dissertations

Generative Adversarial Networks (GANs) are a class of deep learning models capable of producing realistic synthetic data that preserve the statistical and temporal characteristics of real datasets. The DoppelGANger (DGAN) framework extends this approach to time series data by jointly modeling temporal dependencies and contextual metadata. However, synthetic sequences generated by GAN may show temporal misalignment, resulting in inconsistencies when compared with real data. This study presents a postprocessing framework based on Dynamic Time Warping (DTW) and its differentiable extension Soft-DTW to improve the temporal alignment of synthetic time series. The framework is evaluated using quantitative measures of alignment and …

The People’S Medicine: Modern Perspectives On Folk Medicine In South Central Appalachia, Stacey M. Horton

Electronic Theses and Dissertations

The study addresses the critical need to document Appalachian folk medicine conventions and cultural practices from a modern perspective. In so doing, it addresses folk medicine research gaps in understudied places in South Central Appalachia, particularly in Southwestern Virginia and Northeast Tennessee. This research utilizes participant observation and oral history interviews to research modern Appalachian folk medicine practices among a select group of practitioners. Interviews focused on individuals who center their professional careers and subsequent lifestyles around herbalism, foraging, folk medicine, ethnobotany, and botanicals. By utilizing a critical praxis framework, the study seeks to move beyond lists of symptoms and …

Learning To Think, Thinking To Learn: A Qualitative Investigation Of Inquiry-Based Learning And Metacognition In Preschools, Jessica Carter

Electronic Theses and Dissertations

In response to an increased focus in the field of early childhood on inquiry-based practices and metacognition, this qualitative study was designed to investigate a variety of approaches to planning and facilitating classroom inquiry. Additionally, this research was designed to discover the ways in which metacognitive strategies are used in preschool classrooms to foster the learning process. Using teacher interviews, classroom observation, and analyses of teachers’ planning documents in a multiple case study design, this study focused on five Reggio-inspired classrooms to investigate the planning and teaching practices of preschool teachers related to inquiry-based learning. Of importance was their use …

Branding The Divide: Political Ideology And The Strategic Challenges Of Higher Education Marketing, Oscar J. Early Mr

Electronic Theses and Dissertations

The purpose of this qualitative study was to explore how first-year students experience and interpret institutional branding within the context of their personal and social identities, with particular attention to the role of political ideology. While previous research had examined general branding strategies and declining public trust in higher education, scholars have given little attention to the ways in which prospective students make meaning from institutional messaging during one of the most significant transitions of their lives.

I conducted interviews with 12 first-year students from four-year colleges and universities across South-Central Appalachia. The phenomenological analysis revealed that students’ interpretation of …

A Comparative-Correlational Study On The Mental Health And Well-Being Of First-Generation Students At A Historically Black College And University, Shedred Jackson

Electronic Theses and Dissertations

The purpose of this study was to investigate the mental health and well-being of first-generation college students (FGCS) in comparison to non-first-generation college students (NFGCS) at a private Historically Black College and University (HBCU) in the Southeast. This study was undertaken to investigate students' mental health and well-being, as well as their use of, access to, and the availability of mental health services. A comparative-correlational research design was employed to collect and analyze the data. The study used a sample size of 388 responses from undergraduate college students enrolled at the private HBCU. Of the 388 students in the sample, …

Perceptions Of Choral Teachers On The Characteristics Of A Secondary Choral Program, Nathan Dale Rhea

Electronic Theses and Dissertations

The purpose of this study was to examine the perceptions of choral teachers on the characteristics of a successful secondary choral program. The study focused on the main characteristics of excellence, success, and sustainability. The literature showed that there was a significant amount of research on the music curriculum, standards, and various assessment strategies but minimal research on perceptions on the characteristics of excellence, success, and sustainability of a choral music program at the secondary level.

Data collection strategies included individual interviews of eight participants who were choral music educators. The analysis of data occurred through the lens of the …

Strategic Enhancement Of Biofuel Production Using Bacillus Subtilis As A Model Organism: A Dual Approach Of Gene Essentiality Mapping And Optimization, Angela A. Zebede

Electronic Theses and Dissertations

With rising global demand for renewable energy, enhancing microbial platforms for biofuel production is vital. This study engineered Bacillus subtilis to improve resilience to solvent stress by targeting membrane lipid biosynthesis pathways essential for integrity. Growth curve analysis (OD₆₀₀) showed that phosphatidylserine (PS) and phosphatidylethanolamine (PE) knockout strains grew significantly slower than wild type (168), indicating the importance of these lipids under stress. Laurdan fluorescence spectroscopy was used to assess membrane properties. Generalized polarization (GP) analysis revealed a concentration-dependent reduction in membrane order upon 1%–2% 1-butanol exposure. GP values declined progressively from control to 2% treatment, reflecting increased membrane fluidity …

Mountain Communities During A Time Of War: A Case Study Of The Hutsul Region In The Carpathian Mountains Of Ukraine, Pavlo Rybaruk

Electronic Theses and Dissertations

This thesis investigates the ethno-ecological technologies employed by the Hutsul people within the highland agrarian economy of the Carpathian Mountains. Over centuries, the Hutsuls have developed ethno-ecological technologies that maintain ecological integrity while supporting community livelihoods.

The study addresses three primary research questions: What are the most important ethno-ecological technologies of the Hutsul highland economy? How might these traditional ethno-ecological practices be applied to economic, agricultural, and tourism development in the Hutsul region? How might these traditional ethno-ecological practices be combined with contemporary approaches to encourage sustainable development in the region?

The research explores the devastating impact of the Russian …

Divergent Responses Of Branched-Chain And Straight-Chain Lipid Membranes To Butanol Stress Revealed By All-Atom Molecular Dynamics Simulations, Joshua Olaf Aggrey

Electronic Theses and Dissertations

Membrane integrity under chemical stress is critical to cellular survival and industrial microbial bioproduction, yet the molecular basis of bilayer resilience remains poorly understood. Using all-atom molecular dynamics simulation, we compare the effect of increasing concentrations of 1‑butanol on membranes composed of straight-chain (1,2-dipalmitoyl-sn-glycero-3-phosphocholine, DPPC) and branched-chain (1-anteiso-palmitoyl-2-palmitoyl-sn-glycero-3-phosphocholine, APPC) lipids, which differ in the point of attachment of a single methyl group. In the absence of butanol, both membranes exhibit well-ordered architectures consistent with experimental benchmarks; however, under increasing solvent stress, their behaviors diverge markedly. DPPC membranes display gradual thinning, modest area per lipid …

Exploring The Impacts Of Medical Invalidation On Postpartum Parents With Pcos, Shalini Venkat

Electronic Theses and Dissertations

Individuals with polycystic ovary syndrome (PCOS) face an increased risk of poor perinatal health, yet little is known about whether negative healthcare experiences contribute toward these outcomes. Patients with PCOS have reported experiencing invalidation by healthcare providers; however, the effects of these encounters in postpartum populations remain unclear. Using data from an online survey, the current study investigated whether PCOS status moderated the relationships between invalidating communication by healthcare providers, pregnancy and birth complications, postpartum depression, and postpartum anxiety. While experiences of invalidating communication by healthcare providers predicted worse perinatal health, those with PCOS solely experienced an increased risk of …

Típica Style Vs. Latin Jazz: A Comparison Of Traditional Salsa Piano Accompaniment And Latin Jazz Comping, Victorino C. Perez

Electronic Theses and Dissertations

Salsa is a popular Latin American musical genre that combines dance and vocal music with a unique rhythmic style that draws influences from jazz and African rhythms. Salsa shares characteristics with Latin jazz. Traditional salsa, or típica style, features traditional tonal harmonies with few alterations, whereas Latin jazz typically employs complex harmonies including tritone substitutions, chord extensions, and chords with extensions and alterations. The primary argument of this research is that Latin jazz pianists maintain the functions of the traditional salsa while infusing it with jazz harmonic, rhythmic, and textural elements. This thesis compares accompanying (“comping”) traits, including form, harmony, …

World On Fire: The Hunger Games And The Rhetoric Of Revolution, Rachel Olivares

Electronic Theses and Dissertations

In the decade between 2010 and 2020, more people participated in mass protests than at any other point in human history. From the Arab Spring to Occupy Wall Street and Hong Kong’s “umbrella movement,” street demonstrations exploded on a global scale. This period of global unrest coincided with another explosion: the dystopian young adult series The Hunger Games surged in popularity, quickly becoming a cultural phenomenon. Following the release of the book series and its subsequent film adaptations, The Hunger Games became a global symbol of grassroots resistance as social and political movements adopted the language and symbols of its …

A Qualitative Study On Black Women Leaders And Their Career Paths In Higher Education, Beatrice Porter

Electronic Theses and Dissertations

Black women remain significantly underrepresented in senior leadership roles within higher education, especially in the presidency at historically Black colleges and universities. This qualitative phenomenological study explored the career paths and challenges Black women faced through their lived experiences in leadership roles across higher education institutions within predominantly White institutions and HBCUs. Guided by Black Feminist Thought as the theoretical lens, the study examined the intersecting barriers of race and gender that shaped the participants’ leadership trajectories in higher education. Data were collected through open-ended questionnaires, allowing participants to reflect on systemic inequities, mentorship experiences, and leadership development. Findings revealed …

Exploring The Role Of Christian Religiosity In The Acceptance Or Rejection Of Ai Chatbot Use Among Faculty At Church Of Christ Universities, Amos Gutierrez

Electronic Theses and Dissertations

Higher education institutions are navigating the benefits and challenges of generative AI chatbot use and preparing faculty and students to engage with these tools ethically and responsibly. The problem is that there are many challenges and barriers to using these technologies in higher education, and Christian higher education institutions must also address context-specific considerations regarding mission and vision rooted in biblical faith and practice. The purpose of this quantitative, nonexperimental, cross-sectional study using confirmatory factor analysis and multiple regression through structural equation modeling was to examine faculty perceptions of AI chatbots and how Christian religiosity moderates acceptance. An online survey …

Sex, Riots, And Holy Water: How Modern Society Desecrates And Reconsecrates The Sacred, Jodeyah J. Mills

Electronic Theses and Dissertations

This thesis explores how modern societies desecrate and reconsecrate the sacred through rhetoric, ritual, and visual performance. Using three case studies, Nazi Germany’s transformation of Quedlinburg Abbey, the January 6th attack on the U.S. Capitol, and Sabrina Carpenter’s controversial church music video, “Feather,” this project analyzes how sacred meaning is violated and restored in religious, civic, and popular contexts. Drawing on Kenneth Burke’s dramatistic cycle and postsecular theory, it argues that desecration and reconsecration are dialogic acts that expose competing moral vocabularies within culture. Each event demonstrates that even in a secular age, people respond to ruptures of ultimate meaning …

Principals’ Perceptions Of Their Preparedness To Facilitate And Support Technology Integration In Schools: A Case Study Of Four Rural Texas Principals, Christina J. Campbell Ed.D.

Electronic Theses and Dissertations

School administrators face the challenge of leading technology integration that provides meaningful learning opportunities to prepare students for 21st-century skills and careers. Research has shown that administrative leadership support, behaviors, assumptions, and policies impact technology integration in the classroom. The International Society for Technology in Education (ISTE) standards include guidelines for education leaders and their role in supporting educators using technology. However, leaders underestimate the impact of their leadership on effective use in the classroom. The purpose of this qualitative case study was to explore the perceptions of South Texas rural public school principals working in Chapman Independent School District …

Discovering Eternal Sunshine: Storytelling Functions Of Vocal Timbre And Layering In Ariana Grande’S 2024 Album, Emily Mcquaid

Electronic Theses and Dissertations

This thesis analyzes the narrative of Ariana Grande’s 2024 concept album eternal sunshine in relation to the 2004 film Eternal Sunshine of the Spotless Mind. Chapter 1 contextualizes the album and its related media, including music videos, additional album releases, a short film, and interviews with insights from Grande. Chapter 2 realizes Peaches as the narrator of the album, demonstrates how the lyrics of each track of the album connect to the film Eternal Sunshine of the Spotless Mind, and establishes the framework for vocal timbre analysis in the rest of the paper. Chapters 3 through 5 analyze how …

Islamic Political Anti-Theology: A Discursive Practice Of Contingency Beyond Sovereign Politics, Jason Andrus

Electronic Theses and Dissertations

Contributing to the field of political theology from outside the European Christian tradition, this dissertation develops a description of the distinct logics that Islamic theology generates from its metaphysical assumptions. These logics in turn make possible a discourse of political anti-theology where politics operates through contingency rather than sovereignty. Political theology scholarship has excavated how modern politics derives from secularized Christian theological concepts—particularly transcendent sovereignty. This study demonstrates that Islamic theology's absolute insistence on divine transcendence (tawhid) produces something fundamentally different: a politics that renders sovereign authority conceptually impossible. I identify this discursive practice of political anti-theology through …

Museums In Public Libraries: An Ethnographic Case Study Of The Blair-Caldwell African American Research Library, Yadira Y. Quintero

Electronic Theses and Dissertations

Access to information is a human right, and this thesis explores the benefits and challenges of integrating museums into public libraries by conducting an ethnographic case study of the Blair-Caldwell African American Research Library. The study's findings highlight the complexities of integration. The biggest benefit is the increased access to museum collections, information, and resources. However, challenges arise from the lack of cohesion within the museum and library disciplines, as well as strained community relations. Engaging the community is crucial for successful collaboration, emphasizing the importance of a bottom-up approach that allows for active participation. Integrating museums into public libraries …

The Resonance Of Desire: A Sonic Exploration And Guide To Recreating Disney’S Signature ‘I Want’ Songs, Aiyanna E. Riley

Electronic Theses and Dissertations

This thesis explores the sonic architecture of Disney’s Renaissance-era “I Want” songs and develops a framework for recreating their signature production style. This study analyzes how vocal timbre, microphone choices, layering, stereo placement, and mixing strategies contribute to the immersive qualities that define the Disney sound. Drawing from historical accounts, interviews with industry professionals, and technical literature, the thesis documents production practices unexamined in scholarly work. Inspired by David Gibson’s The Art of Mixing, my analyses prioritize spatial and textural qualities in Disney mixes, highlighting how sound design shapes narrative impact. The study culminates in two original compositions modeled …

The Effect Of Perceived Principal Leadership Styles And School Type On Elementary Teacher Self-Efficacy, Karen M. Gonzalez

Electronic Theses and Dissertations

The purpose of this study was to explore the effect of perceived principal leadership styles and school type on elementary teachers’ self-efficacy. The study examined two research questions. The first examined differences between teachers’ self-efficacy in Title 1 and non-Title 1 schools, and the second examined differences in teacher self-efficacy and perceived principal leadership styles (authoritarian, democratic, and laissez-faire). The convenience sample included 129 elementary teachers from social media teacher groups that taught in various Title 1 and non-Title 1 school districts. I used a quantitative, causal-comparative method to collect data and survey questionnaires that identified trends in leadership styles …

In Flux, Gavin G. Gilmore

Electronic Theses and Dissertations

This thesis explores my practice of non-representational, mixed media painting as a way to consider the passage of time and the shifting nature of memory. Working in layers of paper, pigment, paint, and other materials, I build and disrupt surfaces that mirror the instability of short-term memory and the gradual erosion experienced during my father’s journey with Alzheimer’s disease. Each painting becomes a palimpsest where gestures accumulate, fade, or reemerge, reflecting how memories surface, distort, or disappear.

Through this layered process, the work intertwines personal narrative with broader questions of how time is felt rather than measured. The paintings act …

Digital Leadership: Secondary Education Principals’ Perceptions And Change Competencies Toward Implementing Digital Citizenship Curricula, Waylon M. Randolph

Electronic Theses and Dissertations

Secondary education public schools are increasingly being confronted with student misuse of information and communication technologies (ICTs). Students are using these technologies to engage in disruptive and harmful behaviors like cyberbullying and sexting. As a result, some public school districts have responded by banning the use of ICTs in the classroom, while others have turned to teaching digital citizenship through a dedicated digital citizenship curriculum. However, effectively implementing such a curriculum remains a significant challenge. According to the literature, the best way to implement a digital citizenship curriculum is by fostering a positive school culture where stakeholders model and support …

Leading Employees Remotely In A Post-Covid-19 Era: A Phenomenology Study Of Remotely Working Employees, George M. Hardy Jr

Electronic Theses and Dissertations

The problem addressed in this study was that remote working employees felt disconnected from their organizations, leading to post-COVID-19 studies on phenomena such as quiet quitting and the great resignation. The purpose of this study was to investigate remotely working employees’ perspectives on connectedness to gain an understanding of commitment within their organization that ultimately leads to the decision to remain or leave. A qualitative phenomenology study was used with data collected from 12 remotely working participants across multiple industries and states. Data were transcribed, coded, and analyzed using a thematic approach with member-checking and triangulation to ensure credibility. Two …

Beyond Leadership Turnover: Examining The Relationship Between Principal Supervisor Coaching And Student Academic Performance, Margo L. Nottingham

Electronic Theses and Dissertations

Schools that maintain stable leadership report increased student achievement outcomes. The problem is that over 21% of U.S. principals leave their positions in the first year in high-poverty contexts. Principals leave their roles due to high job demands, inadequate support, and limited professional development, leading to decreased performance and poor school culture. The problem examined in this study was the lack of evidence on whether coaching principal supervisors contributed to improved student achievement outcomes. The study aimed to determine whether coaching principal supervisors through a regional service center was associated with higher student achievement in low-performing elementary and middle schools. …

Understanding Digital Communication Gaps With Hispanic Families In A Charter School In South Texas, Ruby Cabrera Aguilar

Electronic Theses and Dissertations

Now that access to technology is prevalent, digital communication in school districts and between schools and parents should be of high priority. Since schools do not emphasize digital communication policies and practices, a problem seen is a lack of communication across districts involving school staff, parents, and students. Determining school leaders’ roles in closing digital communication gaps through policies and procedures deserves further study because effective communication leads to awareness, involvement, relationship building, and student success. In this study, the knowledge gap theory and qualitative action research through reports and interviews assisted in understanding the perspectives of six school staff …