Digital Commons Network^™

Mathematical And Computerized Modeling To Optimize The Dimensions And Percentage Infill For The Targeted Dose Of Different 3d Printed Pharmaceutical Designs With Multiple Case Studies, Sundus Omari

Electronic Theses and Dissertations

Fused Deposition Modeling (FDM) three-dimensional (3D) printing is the most studied method compared to other 3D printing technologies. However, the optimization of the 3D printing design must be done throughout the process for crucial parameters to deliver the desired dose. Optimizing the drug content and tablet weight has challenged researchers while designing the 3D printing dosage form. In this study, the concept of reference tablet and the mathematical modeling were used to correlate the volume of the printed object with its weight to control the height, diameter, and percentage infill of the 3D printed tablets to adjust the dose without …

Implementing Culturally Relevant Pedagogies For Black Students Through Targeted Professional Learning Communities, Willie Reece

Electronic Theses and Dissertations

This action research emphasizes the need to implement curricula to engage marginalized students as well as promote literacy and high levels of academic achievement. Marginalized students include minority students who perform far below their White peers on state assessments. In Chapter I, the action research problem of practice is explored. The major issues at Genesis Elementary School are revealed, and they are targeted through culturally relevant pedagogies. Chapter II outlines relevant literature related to the research topic, and the researchers provide frameworks to guide the study. Chapter III focuses on the preparation and implementation of the action plan for the …

Navigating To The Top: Career Success Experiences Of Black Women Senior Leaders In Higher Education, Gladys R. Peters

Electronic Theses and Dissertations

The career advancement for Black women in higher education is not the same as their counterparts. Gender equity practices fail to challenge homogenous professional communities limiting how race and gender influence leadership advancement for Black women career trajectories. Black women who occupy positions of institutional influence and authority as senior leaders have largely been overlooked in in higher education research. Using a qualitative exploratory approach, this multiple case study explored the lived experiences of 10 Black women presently working in senior leadership roles in four-year public institutions of higher learning. This study sought to contribute to a deeper understanding of …

The Presence And Prevalence Of Underqualified High School Science Teachers In Mississippi, Shelby Ann Watson

Electronic Theses and Dissertations

With growth in STEM postsecondary programs and careers positioned as a national priority, ensuring that K-12 science classrooms are staffed with highly qualified teachers is an important step towards building student interest in STEM and preparing students for STEM careers. However, previous studies of out-of-field teaching have indicated that schools and districts across the country are hiring large numbers of underqualified teachers to fill high-needs positions, such as secondary science and mathematics. Complicating the issue is the fact that data regarding teacher shortages, vacancies, and underqualified teaching are often incomplete or inaccessible. Prior studies have found that underqualified teaching is …

Bounds For Symplectic Capacities Of Rotated 4-Polytopes, Matthew Palmer Zediker

Electronic Theses and Dissertations

Symplectic capacities are a central tool from quantitative symplectic topology which act as symplectic invariants, distinguishing symplectic manifolds as different. There are a wide variety of capacities common in the literature today. The still-open Viterbo conjecture states all normalized symplectic capacities coincide on convex domains. Even upper bounds for these capacities are not completely understood, and there are many hard computational barriers. The recent work of Chaidez and Hutchings as well as that of Haim-Kislev have yielded results simplifying computation of a capacity in the case of convex polytopes. In this thesis, we prove an upper bound on normalized capacities …

A Study Of Electron Energy Response Measurement In The Nova Test Beam Detector, Devesh Bhattarai

Electronic Theses and Dissertations

The NuMI Off-axis electron-neutrino Appearance (NOvA) experiment at Fermilab is a long-baseline accelerator neutrino experiment designed to study and understand neutrinos through their flavor oscillations between two functionally-identical detectors; a 300-ton Near Detector and a 14 kton Far Detector separated by 809 km and placed 14 mrad off-axis to the Neutrinos at the Main Injector (NuMI) neutrino beam produced at Fermi National Accelerator Laboratory (Fermilab). NOvA has key physics goals to determine the neutrino mass hierarchy, probe CP violation in the leptonic sector, and conduct precise measurements of the neutrino mixing parameters. To help further NOvA’s physics reach, the NOvA …

Full Bridge Modeling To Evaluate Effectiveness Of A Seismic Bearing On A Newly Constructed Bridge On I-55, Sandip Gupta

Electronic Theses and Dissertations

Infrastructure constructed should be safe and reliable. Bridges are essential infra structure used by large mass of people on a daily basis. Out of 617,000 bridges across the United States, 42% are at least 50 years old, and 7.5% are considered structurally deficient as per Infrastructure report card. 178 million trips are made on these structurally deficient bridges every day in the US. Thus, a bridge should be designed, not only for Strength and Service limit states, but also for Extreme limit states which includes earthquake. New Madrid Seismic Zone (NMSZ), located in southeastern Missouri, northeastern Arkansas, western Tennessee, western …

Assessing The Economic Feasibility Of Capturing And Utilizing Carbon Dioxide From Ethanol Production In South Dakota, Makiah Stukel

Electronic Theses and Dissertations

Since the Industrial Revolution, anthropogenic greenhouse gas (GHG) emissions have spiked dramatically, prompting discussions on climate change. Mitigating climate change requires significant reductions in global carbon dioxide (CO2) emissions as CO2 is the most abundant anthropogenic GHG. A process that assists in offsetting the exponential growth in CO2 emissions is carbon capture and storage (CCS). Integrating carbon capture technology into the ethanol industry can provide an economically feasible way to achieve net reductions in CO2 emissions. The proposed work investigates the economic viability of applying CCS technologies to the 16 ethanol facilities in South Dakota (SD) and quantifies the potential …

Effectiveness Of Atmospheric Cold Plasma In Inactivating Microorganisms, Nadee Shanika Kaluwahandi

Electronic Theses and Dissertations

In the food processing industry, Cold Plasma (CP) is an emerging green process with a number of potential applications. Cold plasma has mostly been used to reduce microbial counts in foodstuffs and biological materials as well as in different levels of packaging, particularly in cases where there is thermal sensitivity. Recent studies have demonstrated that CP technology is being developed for use in the food and agriculture industries. The primary focus is on the interactions between reactive species and food-borne microbes to inactivate them. The literature review discusses both proven and potential applications for cold plasma in food processing, as …

Action In Causal Set Theory, Santosh Bhandari

Electronic Theses and Dissertations

The aim of this thesis is to explore causal set theory (CST), which proposes that at the smallest level of spacetime, discrete entities known as “spacetime atoms” are causally related to one another, forming the basis for understanding quantum gravity. While theories such as general relativity that operate on a continuous manifold are more appropriate when dealing with the universe on a large scale, it is crucial for the discrete causal points in CST to maintain their causal structure during the continuum approximation to ensure consistency with general relativity. One way to preserve the causal structure is to accurately embed …

Stem And Pre-Health Students’ Diminishing Online Conversation Volume Regarding Majors And Careers Within The Field: Why Higher Education Should Care, Susan Roh

Electronic Theses and Dissertations

The purpose of this study was to determine the STEM and pre-health online mention volume change regarding STEM and pre-health majors, careers, and universities, with the data collection period encompassing August of 2018 through June of 2021. We evaluated if the mention sentiment shifted between academic year periods. The data gathered for this study was procured in collaboration with Campus Sonar and the social-listening tool of Brandwatch, which allowed for specifications of the data collected. Kruskal-Wallis tests were used to determine the means of the majors, careers, and universities mentions and mean sentiment volumes. Changes in not only online conversation …

Development Of Novel Cellular Assay Model And Therapeutic Deep Eutectic Solvents To Optimize The Activity Of Anticancer Agents, Nizam Uddin

Electronic Theses and Dissertations

Multidrug resistance (MDR) is the major burden behind chemotherapeutic treatment failure. It is the principal mechanism by which cancer cells evade chemotherapeutic treatment. As a result, aggressive cancer cells survive and continue uncontrolled cell division. Multidrug resistance affects survival rate of almost all types of cancer patients and death toll rises at an alarming rate. There are seven different mechanisms for evolving MDR. The most common mechanism in efflux activity of overexpressed ABC transporters. MRP1 is a prominent ABC transporter that pumps out a wide variety of anticancer drugs from the cells and thereby reduces intracellular drug concentrations and develops …

Design, Synthesis, And Biological Evaluation Of Novel Steroidal Analogs: Potential Anticancer Agents, Trevor Ostlund

Electronic Theses and Dissertations

Cancer is a malicious disease with low survivability rates primarily due to lack of reliable treatment options. Treatments are often non-specific for patients, and cancer resistance to treatment is becoming more prevalent as fast as new therapies are created. Previous studies in our laboratory have focused on the Epidermal Growth Factor Receptor (EGFR) and its downstream kinase family members as a key target for cancer. This cascade controls cell proliferation, anti-apoptotic effects, cell regulation, and other survival factors. Additionally, ABC transporters, responsible for efflux of chemotherapeutic material from cells, are key targets to combat drug resistance. We first evaluated a …

Soil Health Influenced By Livestock And Cover Crops Integration In Row Cropping Systems In South Dakota, Namrata Ghimire

Electronic Theses and Dissertations

No abstract provided.

Dynamic Modeling Of Commercial-Off-The-Shelf Smart Inverters Using Power-Hardware-In-The-Loop, Bidur Poudel

Electronic Theses and Dissertations

Inverter-based generation is replacing synchronous-based generation in the power grid. In the past, due to the dominance of synchronous-based generation, inverter-based generation dynamics were typically under-modeled as they made little contribution to voltage and frequency control. Looking at the present context, several disturbances, like the Blue Cut Fire (CA), on August 16, 2016, the South Australian Blackout on September 28, 2016, and the Canyon Two Fire Disturbance (CA) on October 9, 2017, etc., are caused by the influence of converter-based resources. So, for converter-dominated power system stability analysis and control, the dynamics of an inverter-based system cannot be under-modeled. In …

Comprehensive Analysis And Forensic Investigation Of Cyanide, Thiocyanate, And 2-Amino-2-Thiazoline-4-Carboxylic Acid In-Ante- And Postmortem Blood Utilizing Advanced Analytical Techniques, Abdullah Hamad Alluhayb

Electronic Theses and Dissertations

Cyanide (CN), present as cyanide anion (CN-) or hydrogen cyanide (HCN), is a deadly poison. The main mechanism of CN toxicity is blocking terminal electron transfer, leading to cellular hypoxia, cytotoxic anoxia, and potential death. Determining blood CN concen-trations along with its major metabolite, thiocyanate (SCN-), is crucial. A sensitive method for concurrent detection of CN and SCN- from human ante- and post-mortem blood via liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) analysis was devel-oped. The method involved active microdiffusion with chemical modification using naph-thalene-2,3-dicarboxaldehyde (NDA) and taurine, while monobromobimane (MBB) mod-ification was used for SCN-. The method showed good sensitivity for …

Factors Influencing Mortality Of Bighorn Sheep (Ovis Canadensis), Emily Moberg

Electronic Theses and Dissertations

Reintroduced bighorn sheep (Ovis canadensis) in Nebraska faced a devastating pneumonia epizootic resulting in variable ewe reproductive success and poor lamb recruitment in many of the herds. From 2015-2017, no lamb recruitment was observed in the northern Pine Ridge subpopulation and as many as 60% of adults died. This was in stark contrast to the healthier Wildcat Hills herds to the south, where lamb recruitment was estimated to be between 50-70% during the same years. From 2018-2020, we radio-collared and recaptured 76 adult female bighorn sheep from 2 of 3 Pine Ridge herds and 1 of 2 Wildcat Hills herds. …

Novel Formulation Strategies With Hot-Melt Extrusion Technology To Address Physicochemical And Physiological Constraints For Improved Oral Drug Delivery, Sagar Narala

Electronic Theses and Dissertations

Most current active pharmaceutical ingredients (APIs) exhibit poor water solubility, necessitating higher doses or repeated administration. Numerous methods were explored to augment solubility, including but not limited to amorphous solid dispersions, cocrystals, salts, and nanoformulations. The hot-melt extrusion (HME) technique has gained immense popularity due to its solvent-free and continuous manufacturing capabilities, contributing to its increasing use to enhance solubility and bioavailability. In the first chapter, hydrochlorothiazide (BCS-IV class) cocrystals were produced using coformers such as nicotinamide (NIC), resorcinol (RSL), and catechol (CAT) through HME technology. The cocrystals were compared against liquid-assisted grinding (LAG) cocrystals and then analyzed by DSC, …

A Discrete Conley-Zehnder Index For Symplectic Polytopes, Yutian Yu

Electronic Theses and Dissertations

A Hamiltonian system is a dynamical system governed by Hamilton’s equations. Hamiltonian systems provide a framework for studying classical mechanics. One fundamental principle in Hamiltonian mechanics is the conservation of energy along the flow of the Hamiltonian vector field. The smooth hypersurface of a Hamiltonian function on a symplectic manifold has a contact structure, and the associated Reeb vector field is, up to a scale, the Hamiltonian vector field. We are interested in the non-smooth case and a symplectic polytope makes a good model to study.

In this dissertation, we study the Reeb dynamics on the boundary of a symplectic …

Molecular Dynamics Simulations For The Mechanical Behavior Of Alpha Quartz With Void Defects Under Tension, Yu Jia

Electronic Theses and Dissertations

The structural and mechanical properties of void-free and single-void α-quartz were investigated using MD simulations with three different interatomic potentials (BKS, Vashishta and Tersoff). Two distinct ensembles, NVT and NPT, were separately applied to investigate the tensile response of α-quartz under uniaxial strain and uniaxial stress states. A comprehensive comparison among different potentials, as well as comparison with currently available experiments, has been made. The BKS and Vashishta potentials accurately predicted the structural properties of void-free α-quartz, while the Tersoff potential was deviated significantly from the experimental data. Under tension, the BKS did a better description for the mechanical performance …

Bio-Inspired Memory Device Based Physical Reservoir Computing System To Solve Temporal And Classification Problems, Md Razuan Hossain

Electronic Theses and Dissertations

In recent years, technological advancements in the field of computing have been limited by the slowing down of Moore’s law, which predicts the doubling of the number of transistors on a microchip every two years. The limitations of traditional solid-state electronics have become increasingly evident, as it is becoming difficult to increase the number of transistors while maintaining their reliability and performance. The breakdown of Dennard Scaling, which describes the power-density relationship in CMOS transistors, and the von Neumann bottleneck, which refers to the limited bandwidth between the central processing unit (CPU) and memory, have further exacerbated the situation. Moreover, …

Exploring Messages About College Attendance And Graduation, Erin Talley

Electronic Theses and Dissertations

Successful completion of a college degree is a growing necessity in the United States of America. Concerns about workforce readiness and the cost of postsecondary education make completion of a college degree a burdensome necessity for individuals and society. Important implications from higher education research have been integral in establishing support programs to enhance college and university admissions, persistence, and graduation. Exploration of students’ home environments (Belasco, 2013; Wladis, Hachey, & Conway, 2018), preparation for college endeavors (Banks, 2022; Gilroy, 2014), fit in college institutions (Grillo & Leist, 2014; Lutz, Bennett, & Wang, 2017), and determination, or GRIT (Duckworth & …

Alternative Southern Communities: Cultural Other "Asians" In Contemporary Fiction About The American South, Mariko Hiwatashi

Electronic Theses and Dissertations

This project explores the representation of minority groups in contemporary U.S. Southern literature, with a particular focus on Asian communities. It not only challenges the conventional perception that Asians in America are primarily associated with the West Coast but also underscores how Asian representation in literature plays a crucial role in illuminating the complexities of regional identity and social structure in the American South.

Historically, Asian immigrants have been part of the Southern landscape since the eighteenth century when Filipino sailors settled in New Orleans. Chinese immigrants also played essential roles as laborers in the post-slavery South. However, their experiences …

How Prepared Are They? Mississippi Teachers’ Perceptions Of Preparedness For English Learners In Content Area Classrooms, Michelle Turonek

Electronic Theses and Dissertations

The purpose of this study was to examine teachers’ perceptions of preparedness for English learners in Mississippi content area classrooms. Specifically, the study examined the feelings and experiences teachers had on their preparedness for English learners. While researching teacher perceptions, the study also attempted to discover the reasoning behind their preparedness through pre-service coursework, professional development, and strategies of second language acquisition. A qualitative approach was used through interviews and a survey to investigate how teachers perceived their preparedness and expressed their experiences. Data was collected from ten Mississippi teachers throughout the state and analyzed by the researcher to identify …

The Mississippi School Funding Formula: A Study Of Adequacy, Marcus E. Cheeks

Electronic Theses and Dissertations

The purpose of this was to examine the relationship between Mississippi public school district per pupil funding disaggregated by funding source (total, federal, state, and local) and student academic achievement gaps within districts based on poverty and race. Pearson's correlational coefficient was used to assess the relationship across 139 Mississippi school districts during fiscal year 2019. State Special Schools, Charter Schools, and Agriculture Schools were excluded from the analysis. School districts lacking a sufficient number of African American and Economically Disadvantaged children to calculate a school proficiency score in ELA and Math were also removed. Thus, the analysis consisted of …

Theoretical Spectroscopy Of Electronically Excited States, Megan Christina Davis

Electronic Theses and Dissertations

Modelling of spectroscopic properties is useful for detection of species which are di_- cult to study in the laboratory. Full reproduction of electronic spectra depends upon reliable spectroscopic data of electronically excited states. However, no means of producing accurate fundamental vibrational frequencies of these states exist. This doctoral work consists of applications of theoretical spectra for prediction and identification of novel species as well as attempts to extend this methodology to effectively treat electronically excited states. The former includes the study of conformers of methanediol and a set of [Al,N,C,O] isomers. The latter is done using equation-of-motion theory to form …

Understanding Human Gut Bacterial Interactions And Their Role In Colonization Resistance Against Clostridioides Difficile Using Mini-Bioreactor Array And Caenorhabditis Elegans As Model Systems, Achuthan Ambat

Electronic Theses and Dissertations

No abstract provided.

Impacts Of Land Cover Change On Urban Heat Island (Uhi) In Denver From 1985 To 2020, Sadia Islam Ritu

Electronic Theses and Dissertations

Rapid urbanization due to land use and land cover change has become one of the major problems in the fastest-growing cities during the past few decades. Land surface temperature has changed dramatically due to urban expansion, and it is a major driver of urban eco-environmental change. Increasing temperature leads to the Urban Heat Island (UHI) problem in rapidly growing cities like Denver, contributing to global warming at multiple scales. UHI study is significant to monitor and mitigate the urban heat islandrelated problem in the study area Denver. Satellite remote sensing analysis ready data (ARD) with 30 m resolution based on …

Some 2-Color Rado Numbers For A Linear Equation With A Negative Constant, Rachel Bergjord

Electronic Theses and Dissertations

An r-coloring is a function Δ that assigns a color to each natural number from 1 to some number n using colors 0, 1, . . . , r − 1. A monochromatic solution (in Δ) to an equation L with m variables is an ordered m-tuple (x1, x2, . . . , xm) where Δ(x1) = Δ(x2) = · · · = Δ(xm) and (x1, x2, . . . , xm−1, xm) solves L. Given a linear equation L and t ∈ N, the t-color Rado number for L is the least integer n (if it exists) such that …

Development And Assessment Of Gamified Process-Oriented Guided Inquiry Learning Activities In Undergraduate Large Lecture Chemistry Courses, Nathan Turner

Electronic Theses and Dissertations

Students who take general chemistry and do not perform well are more likely to pursue an alternative degree or remove themselves from STEM curriculum entirely. Poor academic performance and high student attrition rates in general chemistry courses have resulted in the perception of chemistry courses being gatekeepers for students in pursuit of STEM degrees. Process-Oriented Guided Inquiry Learning (POGIL) has shown promising results in both lecture and laboratory teaching on student performance in chemistry while gamification has been used to enhance student learning experiences to help students grasp chemistry concepts. The current project blends two student-centered approaches, gamification and POGIL, …