Digital Commons Network^™

Adding Varying Degrees Of Performance Feedback Components To The Taped Problems Intervention, Alyson C. Honaker

Electronic Theses and Dissertations

Math fact fluency, the ability to quickly and accurately solve one-digit by one-digit math problems, is a common challenge for many school-aged children. Difficulties with fluency often lead to reliance on inefficient strategies, hindering progress in more advanced math skills. Evidence-based interventions like Taped Problems Intervention (TPI) have demonstrated effectiveness in improving math fluency. However, research suggests incorporating behavioral components such as Performance feedback (PF) and goal setting/reinforcement (GS/R) may enhance its effectiveness. The present study used a multiple-probe across-task design to evaluate the effects of three variations of TPI on the subtraction fluency of five elementary students in a …

The Application Of Macrophage-Targeted, Anti-Inflammatory Celecoxib Nanoemulgel For Nerve Regeneration In Peripheral Nerve Injury, Lu Liu

Electronic Theses and Dissertations

Peripheral nerve injury (PNI) refers to damage to the nerve located outside the brain and spinal cord. PNI is commonly caused by a physical accident (trauma) or medical operation^{1, 2}. The impact on the quality of life of PNI patients is directly correlated to neuropathic pain, resultant depression, and increased stress². Even after recovering from the PNI, patients still experience phantom pain and lose the ability to work due to the loss of tactile sensory or motor function^2-4. However, unlike damage to the central nervous system (CNS), peripheral nerves can regenerate because macrophages clean …

Effect Of Histidine Tag On The Enzymatic Activity Of Pseudolysin And Its Interaction With The Streptomyces Metalloprotease Inhibitor (Smpi) Protein, Adewale Adeboye Adewole

Electronic Theses and Dissertations

Pseudolysin (PLN) protein is a major virulent factor in Pseudomonas aeruginosa infection. PLN belongs to the family of zinc-dependent metalloproteases. It is naturally inhibited by a smaller protein called streptomyces metalloprotease inhibitor (SMPI), secreted by Streptomyces nigrescens. Previous and current studies demonstrate that the interaction between PLN and SMPI offers unique mechanistic insights for drug development against infections caused by P. aeruginosa. This study investigated the effect of N-terminal Histidine (His) tag on the enzymatic activity of PLN and its interaction with SMPI. His-tagged PLN and SMPI proteins were expressed in bacteria and purified by affinity chromatography …

Promoting Metacognitive Awareness Through Exploratory Learning., Ryan J. Patrick

Electronic Theses and Dissertations

Exploratory learning engages learners in novel problem solving before direct instruction. This process is designed to lead learners to experience productive failure. Productive failure, however, has been shown to benefit learners by improving the recognition of knowledge gaps, relevant problem features, and deep structures. This allows learners to better attend to relevant information during the subsequent instruction and improves conceptual understanding. This dissertation investigates the role of metacognitive awareness during exploratory learning, in attempt to identify additional metacognitive mechanisms that support exploratory learning. Two experiments tested the theory that exploratory learning promotes metacognitive awareness in exploratory learning. Groups in both …

Estimation Methods For Bayesian Exponential Random Graph Models Under The Horseshoe Prior., Pamela Linares

Electronic Theses and Dissertations

Networks are powerful tools for modeling the complexity of social interactions, biological systems, and information spread. A leading statistical frameworks for analyzing network data are Exponential Random Graph Models (ERGMs), which provide a principled approach to capturing structural dependencies. However, ERGMs remain challenging to estimate, especially in sparse or high-dimensional settings where models suffer from degeneracy and unstable parameter inference. This paper proposes a penalized Bayesian approach to ERGMs that utilizes the horseshoe prior, a sparsity-inducing global-local shrinkage prior. This prior offers robust regularization while preserving important signals, improving estimation by shrinking irrelevant parameters and reducing the impact of extreme …

Evometric: An Interactive Framework For Scalable Visual Analytics Of Time Series Data With Dynamic Changes., Jiahang Huang

Electronic Theses and Dissertations

In today's data-intensive landscape, rapid advances in digital sensing and recording technologies have enabled the acquisition of high-resolution multimodal time series data, capturing intricate real-world dynamics across various domains such as healthcare, behavioral science, and environmental monitoring. However, the complexity and scale of these datasets present significant analytical challenges, particularly in understanding dynamic changes at both individual and cohort levels. This dissertation introduces EvoMetric, a novel visual analytics framework designed to support scalable exploration and analysis of large-scale multimodal time series data with dynamic changes. EvoMetric seamlessly integrates individual-level temporal dynamics with population-level comparative insights, enabling users to visually …

A Deep Learning Approach For Semantic Segmentation And Its Application On Ctc., Samir Farag Harb

Electronic Theses and Dissertations

This dissertation explores the modeling and analysis of medical images, focusing on the intricate task of colon segmentation and subsequent 3D reconstruction, which are critical steps in Computed Tomography Colonography (CTC) systems. The primary objective of this research is to develop precise segmentation approaches to enhance the accuracy of colon identification and reconstruction from abdominal CT scans. Three distinct segmentation approaches are proposed and evaluated: a Markov Random Field (MRF)-based approach, a convolutional neural network (CNN)-based deep learning (DL) approach, and a sequential episodic training with dual contrastive learning Approach (G-SET-DCL) that has a flavor of few-shot learning (FSL). To …

Recent Studies On The Reactions And Synthesis Of Nitrogen And Sulfur - Containing Heterocyclic Pharmacophores., Bernard Louis Adjei

Electronic Theses and Dissertations

Nitrogen and sulfur-containing heterocycles remain significant classes of compounds in the field of medicinal and organic chemistry due to their unique structural features and diverse biological activities which make them of considerable interest for drug discovery and development. Notable examples of the nitrogen containing heterocycles include the phthalimide and glutarimide rings present in thalidomide. Thalidomide, a potent small-molecule therapeutic agent, precipitated a significant global drug crisis due to its teratogenicity, causing congenital malformations in phocomelia infants, which remains unrivaled over half a century ago. Currently, thalidomide derivatives are extensively utilized in the therapeutic management of various hematological malignancies. Recent investigations …

Opportunities For Mathematical Thinking (Omt) In Fourth Grade Mathematics Textbooks., Lucas Wayne Elliott

Electronic Theses and Dissertations

Mathematical thinking is essential not only for students’ academic achievement but also for their ability to compete in a global workforce (Schoenfeld, 1992; Mullis & Martin, 2017). However, students in the United States continue to lag behind their international peers on assessments that measure mathematical thinking (Mullis et al., 2020; van Davier et al., 2024). These gaps emerge as early as elementary school, where the foundation for future academic success is established (Aunola et al., 2004; Locuniak & Jordan, 2008). Given the importance of mathematical thinking and the persistent disparities in student performance, this study examined how mathematical thinking is …

Optimization And Simulation Models For Integrating Social Determinants In Assessing And Optimizing The Accessibility And Efficiency Of Community Pharmacy Networks., Md Morshedul Alam

Electronic Theses and Dissertations

Community pharmacies are essential components of the healthcare system, serving not only as points of medication access but also as providers of health consultations and preventive care. However, disparities in pharmacy access persist due to a combination of geographic, socioeconomic, and behavioral factors. This dissertation develops a comprehensive methodological framework to evaluate and improve accessibility to community pharmacies, integrating optimization, choice modeling, and discrete event simulation. First, we develop an Optimal Community-Pharmacy Assignment (OCPA) model to quantify geographic accessibility across a regional population network. The model minimizes risk-adjusted travel distances between population centers and pharmacies, incorporating social determinants of health …

Remotely-Sensed Urbanization And Local Perceptions Of Change From 1985-2024 In Southern Indiana., Marlea Ferber

Electronic Theses and Dissertations

This study is focused on the land cover change of non-built land cover being transformed into built land cover in two counties in Southern Indiana using mixed methods. Remote sensing was used to identify and quantify land cover change, and interviews were used to understand local perceptions of the physical land cover changes. The study area is situated along the rural-urban continuum with Louisville, Kentucky across the Ohio River. It is important to quantify the amount of land change conversion to built settlement as patterns and rate of urbanization help us to better manage transitions along the rural-urban continuum, but …

Synthetic And Pharmacological Diversity Of Nitrogen-Containing Heterocycles., Shramana Ghosh

Electronic Theses and Dissertations

Nitrogen-containing heterocycles are a foundational class of compounds in organic chemistry, playing critical roles in pharmaceuticals, agrochemicals, and natural products due to their structural diversity and biological relevance. Among them, isoindolinones are notable for their wide range of pharmacological activities. Structurally, isoindolinones possess a benzylic methylene group adjacent to the nitrogen atom, which allows for selective oxidative transformations to yield phthalimide derivatives, well-known intermediates in synthetic, pharmaceutical, and materials chemistry. Although phthalimide is traditionally employed as a protecting group for amines via the Gabriel synthesis, isoindolinone offers a valuable alternative. Through a modified Gabriel-like approach, isoindolinones can serve as more …

Dust Observations Of Occulting Galaxy Pair Vv 191., Clayton Robertson

Electronic Theses and Dissertations

The presence of dust grains as part of the the interstellar medium (ISM) in galaxies is an all-impactful entity in astronomy due its influence on light, and therefore observations. Unlike a true blackbody, dust absorbs, reflects, reddens, and scatters light within a line of sight. We quantify this phenomena with attenuation: the difference between the observed and true magnitudes of an astronomical object due to dust. Therefore, to map dust attenuation, one needs a known background source of light. In the serendipitous case of partially overlapping –occulting– galaxies, the background galaxy serves as the known light source and the transmission …

Predictor-Informed Bayesian Nonparametric Clustering., Md Yasin Ali Parh

Electronic Theses and Dissertations

In this dissertation, we performed clustering of observations such that the cluster membership is influenced by a set of predictors. To that end, we employ the Bayesian nonparametric Common Atom Model (CAM), which is a nested clustering algorithm that utilizes a (fixed) group membership for each observation to encourage more similar clustering of members of the same group. CAM operates by assuming each group has its own vector of cluster probabilities, which are themselves clustered to allow similar clustering for some groups. We extend this approach by treating the group membership as an unknown latent variable determined as a flexible …

Bleeding Out From The Redlining: An Autoethnographic Study Of Racial Equity Policy Enactment In A Large, Urban School District., Anderson Aven Cook

Electronic Theses and Dissertations

This autoethnographic study investigates the enactment and impact of racial equity policies within Jefferson County Public Schools (JCPS), a large urban school district in Louisville, Kentucky. The research is motivated by the ongoing challenges of achieving true educational equity for Black and Brown students, a struggle rooted in historical injustices such as redlining. Despite over seven years of policy implementation aimed at promoting racial equity, academic and behavioral disparities between Black and Brown students and their White counterparts have shown little improvement. Utilizing a qualitative methodology, this study employs autoethnography to intertwine personal narrative with scholarly analysis, exploring the lived …

Polymathy: The Foundational Source Of Creativity And Innovation., Michael Araki

Electronic Theses and Dissertations

In an era of mounting complexity and a growing need to transcend siloed thinking, this dissertation advances polymathy as a critical yet underexplored construct in the management and behavioral sciences. Polymathy is framed as an expansive approach to the pursuit, development, and application of knowledge, marked by the conjunction of breadth, depth, and integration. Building on a thought lineage that stretches from Ancient Greece through the Renaissance to the present day, this work shows that polymathy is neither a relic of the past nor an achievement reserved for a few—but a mode of being, thinking, and acting in the world …

Effects Of A Speech-To-Text Assistive Technology Writing Accommodation For Students With Cerebral Palsy, Kirstin Franklin

Electronic Theses and Dissertations

Cerebral palsy (CP) is a motor disability characterized by impairments in movement, muscle tone, or posture that can also include intellectual, executive functioning, language and memory skills, and academic achievement deficits in children with CP (Centers for Diseases Control and Prevention [CDC], 2022; Levitt & Addison, 2019). These neurological consequences and motor impairments can impact written expression. The aim of this study was to evaluate the effects of a speech-to-text assistive technology (AT) accommodation that was applied to circumvent the impaired spelling and handwriting (i.e., transcription) skills resulting from CP. Three male students (Grades ranged from 6-10) with CP participated …

Preschool Teachers’ Perspectives On Conceptual Movement In Academic Instruction: A Mixed- Methods Study With Implications For Early Math, Kehinde H. Orimaye

Electronic Theses and Dissertations

This convergent mixed-methods study investigated Missouri preschool teachers’ familiarity, implementation, and perceptions of conceptual movement (CM), the purposeful integration of bodily actions to support young children’s understanding of abstract academic concepts, particularly in early mathematics instruction. Grounded in embodied cognition and informed by enactivism and the theory of event coding (TEC), the study explored: (a) preschool teachers’ awareness and frequency of CM use; (b) how teacher characteristics such as experience, age group taught, and math anxiety relate to CM implementation; and (c) teachers’ perceptions of CM’s instructional value, implementation challenges, and professional development needs.

Quantitative data were collected through a …

Electrochemical And Electrocatalytic Properties Of Screen-Printable Carbon Inks Featuring Pyridinic Nitrogen-Containing Polymeric Binder, Albert Sam Junior

Electronic Theses and Dissertations

Screen-printable conductive inks have been widely applied to prepare electrodes for electrochemical sensing. These inks generally consist of conductive metal or carbon particles, solvents, and polymeric binders. Low-cost, carbon-based, screen-printable conductive inks are especially popular. However, screen-printed carbon electrodes (SPCEs) must often be modified after they are printed to impart the necessary characteristics (e.g., sensitivity, selectivity, stability) for the desired application. For example, nitrogen-doping of SPCEs, especially in ways that introduce pyridinic or pyrrolic nitrogen species, can impart electrocatalytic properties towards reduction of O₂, H₂O₂, and CO₂. While our previous work done …

Coastal Transition Zone Development Effects On Salt Marsh Ecology, Amanda Mei Pysher

Electronic Theses and Dissertations

The coastal transition zone (CTZ) is a regional gradient linking terrestrial and marine systems, comprising of the terrestrial upland, the marsh-upland ecotone, and estuarine salt marshes. Along all US coastlines, including the South Carolina (SC) coast from Little River to Georgetown, increases in anthropogenic development of terrestrial uplands have altered the historically established vegetation, and various physical, chemical, biological, and geological gradients. Despite the CTZ's ecological importance, the trickle-down effects of terrestrial upland development on associated high marsh habitats remain understudied. Data were collected from developed (DEV) and undeveloped (UND) shorelines across three SC estuarine inlets. Multilevel modeling (MLM) was …

Migratory Patterns Of Juvenile Shortfin Makos (Isurus Oxyrinchus): Evidence Of A Nursery In The Western North Atlantic, Julia A. Crews

Electronic Theses and Dissertations

Shortfin Makos, Isurus oxyrinchus Rafinesque, 1810, are lamnids that have a global distribution in temperate and tropical oceans. Locations of critical early life history events including birthing and nursery areas are unknown or unconfirmed for most populations. The objective of this study was to identify if a nursery area for Shortfin Makos in the northern waters of the Mid-Atlantic Bight using the criteria articulated by Heupel et al. (2007). Satellite tags were used to track the movement of juveniles (<200 cm TL, n=7) up to 5 months. Tag detections (n=882) confirmed that young makos stay in continental shelf waters of the northern Mid-Atlantic Bight off Long Island through the meteorological summer (June–August) and early meteorological fall (September–October) when sea surface temperatures are 18–23°C. There was clear migratory movement from juveniles once sea surface temperatures fell below 15°C. During late fall, some young sharks moved south towards Cape Hatteras, North Carolina, while one shark moved east up to 1,800 km into the open north Atlantic Ocean into meteorological winter. These movement data of juvenile Shortfin Makos combined with multi-year catches and sightings (2018–2024) provide strong evidence for a nursery area in the northern Mid-Atlantic Bight. By identifying a nursery area for Shortfin Makos, knowledge gaps that currently exist for this vulnerable species and support effective management can be closed.

Impact Of Aleks On Math Achievement For Students Who Were Socially Promoted, Jenifer Michelle Goff

Electronic Theses and Dissertations

This research examines the impact of ALEKS on student achievement in mathematics, specifically the correlation between mastering course concepts and preparedness for Algebra 1 as assessed by MAP RIT scores. The investigation focuses on the problem that many students lack the foundational skills necessary for success in Algebra 1 and higher-level math courses, leading to the research questions: "How does student completion in the ALEKS intervention course impact their performance on MAP?" and "How much more likely are students who completed the intervention course to be considered Algebra 1-ready based on MAP than those who did not?"

The study employed …

Comparison Of Nutrient Concentrations And Primary Production Indicators Across Plume Fronts, Taylor Dishon

Electronic Theses and Dissertations

Coastal buoyant plumes carry low-salinity waters containing particulate and dissolved terrestrial materials with an abundance of nutrients into the coastal ocean, including inorganic nitrogen and phosphorous. Plume fronts act as transport barriers created from the convergence of a fresher plume with an older, saltier plume or with ambient waters, leading to potential accumulation of phytoplankton and nutrients. This accumulation creates an optimal environment for primary production. The primary goals of this study were: to investigate the distribution of and potential relationships between nutrient concentrations and chlorophyll a across plume fronts of the Winyah Bay River Plume, and examine potential relationships …

Therapeutic Potential Of Sglt2 Inhibitors In A Repeated Love Dose Cisplatin Model., Dianet C. Sanchez

Electronic Theses and Dissertations

Cisplatin is a potent chemotherapeutic, thirty percent of patients develop Acute Kidney Injury (AKI). These patients are ten times more likely to develop chronic kidney disease (CKD). Sodium-glucose-cotransporter-2-inhibitors (SGLT2i), FDA approved for diabetes, has shown protection in multiple mouse models of AKI-CKD. We hypothesize SGLT2i can protect the kidney in a model of repeated low dose cisplatin with/without cancer. B6:129 mice with/without lung adenocarcinoma (Lung-adeno) were treated daily with SGLT2i dapagliflozin (10mg/kg)/vehicle control. After seven days, weekly cisplatin (7mg/kg)/vehicle control was initiated for 3-4 weeks. Following final cisplatin dose, kidney function, injury, fibrosis, inflammation was assessed. SGLT2i treatment attenuated alterations …

An Exploration Of Factors Influencing Sophomore-Year Persistence At A Regional Institution In Southern Appalachia, Jonathan W. Mitchell

Electronic Theses and Dissertations

The purpose of this qualitative and interpretative phenomenological study was to explore factors that participants identified as playing roles in their persistence through their sophomore years at a regional university located within Southern Appalachia. Research on second-year retention efforts is far lacking compared to first-year retention efforts. Reflecting the heavy emphasis placed on the first year, there is also more research on first-year retention. However, students can feel a sharp decline in support entering sophomore year, making that just as critical of a transition. Student retention has been emphasized in higher education since its inception, as an institution’s goal in …

Examining The Lived Experiences Of International Students At East Tennessee State University, John The Baptist Anodjo

Electronic Theses and Dissertations

This research investigates the lived experiences of international students at East Tennessee State University (ETSU), specifically examining how they navigate social, academic, and structural challenges. Through in-depth interviews with 20 international students from a variety of nationalities, I analyzed issues related to legal status, housing, food insecurity, healthcare, and social integration. I found that students encounter barriers due to immigration policies, financial constraints, and limited access to essential resources. Additionally, international students benefit significantly from support provided by campus services, community organizations, and their social networks, which play a vital role in their adjustment process. While institutional resources are beneficial …

Mixture Effects On Metal Accumulation In The Asian Clam, Corbicula Fluminea, Mark A. Huff

Electronic Theses and Dissertations

Field collected Corbicula fluminea were exposed to trace level copper, lead, and zinc with the aim of examining the preferential accumulation between the soft tissue and shell. Metal levels were based on those in a permitted industrial effluent. At 1X effluent and 2X effluent exposure levels, copper was found to preferentially accumulate in the clam soft tissue, lead was found to preferentially accumulate in the clam shell, and zinc was found to excrete back into the diluent after preferentially accumulating in the clam soft tissue. When exposed as a mixture at 1X effluent levels, copper and lead were found to …

Integrated Stem Education For In-Service K-5 Elementary Teachers: Definitions, Self-Efficacy, And Teaching Practices, Amani Alhassan

Electronic Theses and Dissertations

Increasing interest has been evident in implementing integrated science, technology, engineering, and mathematics (STEM) teaching in public schools. However, teachers need to be professionally prepared and increase self-efficacy in teaching integrated STEM in their classrooms. Little is known about how teachers' self-efficacy in teaching integrated STEM is related to teachers' practices around STEM integration, particularly in K-5 classrooms.

This convergent mixed-methods study involved surveys with open- and close-ended questions to determine the integrated STEM perceptions, definitions, classroom teaching practices, and self-efficacy level in teaching integrated STEM for 79 northeast Tennessee K-5 teachers. The study also investigated the relationship between teachers' …

Diagenesis And Controls On Porosity And Permeability In The Upper San Andres Formation Of West Texas, Jack Butcher

Electronic Theses and Dissertations

West Texas reservoirs on the Central Basin Platform (CBP) are dominated by Permian-age carbonate deposits, significantly contributing to petroleum production. The Upper Permian-aged San Andres Formation, composed primarily of dolomite and limestone, is a prolific reservoir. This study assesses diagenetic influences on porosity and permeability within the San Andres Formation along the northern CBP. Two cores from the Monument 4-2 and Peterson 1 wells in West Texas were analyzed using core descriptions, thin section petrography, XRD, XRF, and MICP. Results indicate that dolomitization enhances porosity, with intercrystalline and moldic porosity being dominant, while late-stage cementation and compaction reduce permeability. XRD …

An Evaluation Of Key Components Of Natural Resource Camps, Undergraduate Persistence And Success In Natural Resources, Brandy Bishop

Electronic Theses and Dissertations

This study explores the key components that connect natural resource camps, undergraduate persistence, and overall success through gainful employment within the natural resource industry. The aim of this study was to assess early interest and attitudes towards natural resource career pathways and how education interventions shape students’ career outcomes thus leading to overall success. A longitudinal mixed method design was used combining Conservation Careers Camp survey data (n = 39) with institutional records for Forestry majors (n =655) in the Arthur Temple College of Forestry and Agriculture on the Stephen F. Austin State University campus. Quantitative data was analyzed through …