Digital Commons Network^™

An Interactive Interface For Nursing Robots., Ankita Sahu

Electronic Theses and Dissertations

Physical Human-Robot Interaction (pHRI) is inevitable for a human user while working with assistive robots. There are various aspects of pHRI, such as choosing the interface, type of control schemes implemented and the modes of interaction. The research work presented in this thesis concentrates on a health-care assistive robot called Adaptive Robot Nursing Assistant (ARNA). An assistive robot in a health-care environment has to be able to perform routine tasks and be aware of the surrounding environment at the same time. In order to operate the robot, a teleoperation based interaction would be tedious for some patients as it would …

Advances In Tumor-Targeted Therapy Using Nanomedicine., Divya Karukonda

Electronic Theses and Dissertations

Despite continuous improvement and significant progress made in diagnostic and therapeutic approaches for cancer, it is still the leading cause of death worldwide. Although conventional chemotherapy has made significant advances in improving patient survival the indiscriminate destruction of normal cells leads to severe side effects and poor clinical outcomes. Thus, there is a need for effective delivery of drugs to the tumor site avoiding normal tissues to reduce toxicity in the rest of the body. For this reason, a novel multidisciplinary field called Nanotechnology has evolved in recent years and advances in this field have contributed to the development of …

Prevention And Treatment Of Familial Adenomatous Polyposis And Colorectal Cancer By Bilberry-Derived Anthocyanidins., Ashley M. Mudd

Electronic Theses and Dissertations

Colorectal cancer (CRC) is the third leading cause of cancer-related deaths within the United States. Familial adenomatous polyposis (FAP) is an inherited disorder which if left untreated will develop into colon cancer. The family of plant-derived compounds, anthocyanins, show significant therapeutic potential against a variety of diseases, however, they are limited by their instability and poor bioavailability. The goal of my Master’s research project was to determine whether anthocyanidins (non-glycosylated anthocyanins) are more effective than the native anthocyanins, and whether exosomal formulation of anthocyanidins (ExoAnthos) can enhance therapeutic potency compared with free Anthos against both FAP and CRC. The antiproliferative …

Coal Ash Exposure And Asthma In Children., Jack Anthony Pfeiffer

Electronic Theses and Dissertations

This study examined the association between exposure to coal ash in the home among children aged 6-14 and asthma. Data was collected using personal modular impactors, lift tape samples, toe/finger nail samples, questionnaires, and peak flow meters. Laboratory methods used to analyze the samples included gravimetric analysis, scanning electron microscopy (SEM) / energy dispersive x-ray (EDX), and proton-induced x-ray emission (PIXE). Statistical methods used to analyze the data included the Chi Square Test of Independence, logistic regression, the Hosmer-Lemeshow Goodness of Fit test, Fisher’s Exact Test, and the Anderson-Darling Normality Test. Sample size was small, making statistical significance in calculated …

The Comparative Cytotoxicity And Genotoxicity Of Hexavalent Chromium In Humans And Sea Turtles., Rachel M. Speer

Electronic Theses and Dissertations

Monitoring the health effects of environmental contaminants can be achieved using sentinel species as models. Leatherback sea turtles (Dermochelys coriacea) are an endangered marine species that may experience prolonged exposures to environmental contaminants including hexavalent chromium [Cr(VI)]. While Cr(VI) has been identified as a known human carcinogen, the health effects in marine species are poorly understood. In this study the cytotoxic and genotoxic effects of particulate and soluble Cr(VI) were assessed in leatherback lung cells and compared to those in human lung cells. Cr(VI) induced a concentration-dependent increase in cytotoxicity and genotoxicity in leatherback lung cells indicating Cr(VI) …

Biomechanical Testing Of An Exercise For Strengthening The Proximal Femur., Alyssa Osbourne

Electronic Theses and Dissertations

Based on the principles of cutting edge bone remodeling research, a unique therapeutic exercise device was designed specifically to improve bone quality at the most critical location of the proximal femur prone to fracture: the superior-lateral femoral neck where the fracture first initiates during a fall. The exercise/device is intended to work by inducing enough strain in the bone to stimulate the body’s natural bone remodeling mechanisms to increase bone density in the proximal femur and consequently prevent a fracture from arising if a fall to the side does occur.

In order to test the proposed exercise, experiments simulating the …

Custom Software For The 3d Printing Of Patient Specific Plate Bending Templates In Pelvic Fracture Repair., Gordon B Lents

Electronic Theses and Dissertations

The purpose of this work is to reduce the operative time and blood loss incurred during open reduction and internal fixation (ORIF) of traumatic pelvic injuries through the creation of patient specific bending templates for reconstruction plates. These templates are 3D printed in a resin capable of being sterilized and taken into the operating room so that bending may be performed by the surgeon before the patient is opened or by another team member in parallel with the surgeon.

A novel software extension was created in 3D modeling software to allow a surgeon to individually position screws on a pelvic …

The Macro-Modelling Of Steel Fiber Reinforced Concrete/Mortar Flexural Tensile Behavior And Mix Optimization For Flexural Strength., Li Liu

Electronic Theses and Dissertations

With the continuous advances in materials’ technology, the performance of the commonly used concrete building material has continued to improve. Compressive strengths exceeding 75 MPa are now being used in applications throughout the world. However, the concrete becomes less ductile and more susceptible to sudden failures with increases in its compressive strength. Although the behavior of concrete is generally governed by its compressive strength, its tensile strength, although much lower, is also important. This tensile strength impacts appearance, the serviceability and durability of concrete elements. In addition, minimum levels of tensile strength are required for many concrete applications including, earthquake …

Spiritual Transcendence As A Sixth Personality Factor In Russia : Cross-Cultural Generalizability And Influence On Psychosocial Outcomes., Ksenia Kopeikin

Electronic Theses and Dissertations

Previous research has suggested that Spiritual Transcendence (ST), which is the ability to stand outside one’s own immediate experience, to see unity in nature and to feel connection with the rest of humanity and the spirits, is a universal human experience. Research also suggests that ST may form a sixth personality factor, operating in a manner similar to, but separately from the Big Five personality traits. That is, ST may be a source of intrinsic motivation and influence human behavior and psychosocial outcomes similar to the Big Five. Previous research has established the incremental validity of ST over and above …

Accurate And Justifiable : New Algorithms For Explainable Recommendations., Behnoush Abdollahi

Electronic Theses and Dissertations

Websites and online services thrive with large amounts of online information, products, and choices, that are available but exceedingly difficult to find and discover. This has prompted two major paradigms to help sift through information: information retrieval and recommender systems. The broad family of information retrieval techniques has given rise to the modern search engines which return relevant results, following a user's explicit query. The broad family of recommender systems, on the other hand, works in a more subtle manner, and do not require an explicit query to provide relevant results. Collaborative Filtering (CF) recommender systems are based on algorithms …

The Role Of Hif-1Α In Intestinal Epithelial Barrier Function In Alcoholic Liver Disease., Tuo Shao

Electronic Theses and Dissertations

Hypoxia inducible factor 1 α (HIF1α) is an oxygen-responsive subunit. HIF-1α plays a pivotal role in many pathophysiological processes. In addition to oxygen availability, HIF-1α can be regulated by multiple other factors in response to various pathophysiological processes. Previous studies showed that hepatic HIF-1α could be beneficial or harmful in experimental alcoholic liver disease (ALD). However, the role of intestinal HIF-1α in ALD has not yet been studied. Given the critical role of the gut-liver axis in ALD, it is important to elucidate the role of intestinal epithelial HIF-1α in ALD. In the first chapter, we used wide type (WT) …

The Dlk1-Meg3 Locus In Malignant Cells Of Proposed Primordial Germ Cell Origins., Zachariah Payne Sellers

Electronic Theses and Dissertations

Primordial germ cells (PGCs) are hypothesized to deposit hematopoietic stem cells (HSCs) along their migration route through the embryo during the early stages of embryogenesis. PGCs also undergo global chromatin remodeling, including the erasure and reestablishment of genomic imprints, during this migration. While PGCs do not spontaneously form teratomas, their malignant development into germ cell tumors (GCTs) in vivo is often accompanied by the retention of hypomethylation at the IGF2-H19 imprinting control differentially methylated region (DMR). Previous studies in bimaternal embryos determined that proper genomic imprinting at two paternally imprinted loci was necessary for their growth and development: Igf2-H19 and …

Bayesian Approach On Short Time-Course Data Of Protein Phosphorylation, Casual Inference For Ordinal Outcome And Causal Analysis Of Dietary And Physical Activity In T2dm Using Nhanes Data., You Wu

Electronic Theses and Dissertations

This dissertation contains three different projects in proteomics and causal inferences. In the first project, I apply a Bayesian hierarchical model to assess the stability of phosphorylated proteins under short-time cold ischemia. This study provides inference on the stability of these phosphorylated proteins, which is valuable when using these proteins as biomarkers for a disease. in the second project, I perform a comparative study of different confounding-adjusted to estimate the treatment effect when the outcome variable is ordinal using observational data. The adjusted U-statistics method is compared with other methods such as ordinal logistic regression, propensity score based stratification and …

Ubqln1 : A Multi-Domain Protein With Multiple Functions., Zimple Kurlawala

Electronic Theses and Dissertations

There are 5 Ubiquilin proteins (UBQLN1-4, UBQLN-L), which are evolutionarily conserved and structurally similar. UBQLN proteins have 3 functional domains: N-terminal ubiquitin-like domain (UBL), C-terminal ubiquitin-associated domain (UBA) and STI chaperone-like regions in the middle. Alterations in UBQLN1 gene have been detected in a variety of disorders including Alzheimer’s disease, Amyotropic Lateral Sclerosis and lung cancer. UBQLN1 has been largely studied in neurodegenerative disorders in the context of protein quality control. Several studies have hypothesized that the UBA domain of UBQLN1 binds to poly-ubiquitin chains of substrate and shuttles it to the proteasome via its UBL domain for degradation. UBQLN1 …

Porphyromonas Gingivalis Infection In Gestational Diabetes Mellitus And Survival In Tobacco Smokers., Himabindu Gogeneni

Electronic Theses and Dissertations

This thesis contains a clinical project and distinct basic science project. Gestational diabetes mellitus occurs in 4% of pregnancies and increases the risk of birth defects, pre-term birth, and miscarriage. Gingivitis during pregnancy also increases the risk for poor pregnancy outcome. Gingivitis is a bacterial-induced disease, and specific plaque pathogens have been associated with systemic sequelae to periodontal inflammation. Therefore, we set out to monitor oral infection with three key periodontopathogens (Porphyromonas gingivalis, Filifactor alocis, and Treponema denticola) and the systemic inflammatory burden [C-reactive protein (CRP) in pregnant women with and without gingivitis and gestational diabetes. Gingivitis …

Self-Forgiveness In Japanese Adolescents., Tetsuo "Ted" Sato

Electronic Theses and Dissertations

The literature of forgiveness has been proliferated the last two decades (Davis et al., 2015b), but it has primarily focused on forgiveness of others and the research of self-forgiveness has just increased in recent years (Worthington & Langberg, 2012). Woodyatt and Wenzel (2013a) proposed a process-oriented approach of self-forgiveness while considering three possible responses to the self (i.e., genuine self-forgiveness, pseudo self-forgiveness, and self-punitiveness) after interpersonally offending others. Self-forgiveness among children and adolescents and in Japanese culture was discussed. The association of self-forgiveness to depressive and anxiety symptoms, and culturally and developmentally unique factors (i.e., fear of negative evaluation and …

Attending To Systemic Racism : Advancing Public Health's Approach To Youth Violence Prevention., Billie Faith Castle

Electronic Theses and Dissertations

This dissertation examines how the field of public health addresses the impact of systemic racism on health and how that informs public health’s approach to youth violence prevention. Beginning with an overview of youth violence, it breaks down the concepts of race and racism and how they are addressed within the science. It also reviews concepts that contribute to risk and protective factors of youth violence. The dissertation is written from a Critical Race Theory approach, argues that the social environment contributes to why youth violence is pervasive in certain neighborhoods, and promotes action from a macro-level approach. Seven chapters …

The Relationship Between Trauma And Health-Related Quality Of Life In Lung Cancer Patients : The Potential Protective Role Of Mindfulness., Rene Bayley-Veloso

Electronic Theses and Dissertations

Lung cancer is the most common malignant disease worldwide, and the rapid decline in functioning due to the often-later stage diagnosis can strongly impact a patient’s health-related quality of life (HRQOL). Palliative care, with the aim of improving later-stage HRQOL, is often a main goal of treatment. Compared to other cancer types, patients with lung cancer experience the greatest amount of psychological distress during and after treatment. Prior trauma exposure, and the potentially traumatic nature of the cancer experience, can further complicate HRQOL. Mindfulness, an innate or acquired capacity for sustaining attention in the present moment with qualities of self-warmth …

Preparing For Racial Discrimination : The Role Of Cognition And Emotion In The Proactive Coping Process Of African American College Students., Ryan Christopher Tyler Delapp

Electronic Theses and Dissertations

Traditionally, conceptual models of racial discrimination have characterized the reactive experiences of African Americans, particularly identifying how African Americans cognitively, emotionally, and behaviorally respond to racial stress. The current study extends beyond the reactive coping experience and identifies nuances in the anticipatory and preparatory coping processes associated with racial discrimination. Methods: 62 African American college students participated in a stress induction experiment that prompted anticipatory judgments of discrimination. The full sample completed quantitative self-report questionnaires about their anticipatory thoughts (SAM; Peacock & Wong, 1990; Roesch & Rowley, 2005), state-based affect (PANAS-X; Watson & Clark, 1994), and proactive coping behaviors (PPCB; …

Bdnf-Trkb Signaling Regulates Adult Taste Bud Innervation., Tao Tang

Electronic Theses and Dissertations

Taste receptor cells transduce stimuli transmitting information to gustatory neurons that carry it to the brain. They turn-over continuously in adulthood, and must be constantly reinnervated, making the maintenance of innervation to taste buds an active process mediated by many factors, including brain-derived neurotrophic factor (BDNF). Taste bud innervation (40%) is lost when Bdnf is removed during adulthood, but it is unclear why remaining fibers were not lost. We found that some gustatory nerve fibers remained because they lack the TrkB receptor 55% of TrkB-labeled fibers were lost and fibers without TrkB remained following adult Bdnf gene recombination. It is …

Magnetic Field-Induced Intramolecular Cyclization As A Trigger For Nanoparticle-Based Delivery Systems., Sara Katherine Biladeau

Electronic Theses and Dissertations

Magnetic nanoparticles (MNPs) are used in a variety of applications, including as agents for magnetic resonance imaging, generation of local hyperthermia, and as platforms for drug delivery. Iron-based MNPs are often coated with a shell, such as silica or gold, to increase biocompatibility for drug delivery applications. Many MNPs used for cancer therapy rely on either an internal trigger, such as a difference in pH, or an external trigger, such as light or an alternating magnetic field (AMF), to cause release of a payload, typically a chemotherapeutic drug. Internal triggers are appealing because drug release can be targeted to a …

A Cross-Sectional Exploration Of Household Financial Reactions And Homebuyer Awareness Of Registered Sex Offenders In A Rural, Suburban, And Urban County., John Charles Navarro

Electronic Theses and Dissertations

As stigmatized persons, registered sex offenders betoken instability in communities. Depressed home sale values are associated with the presence of registered sex offenders even though the public is largely unaware of the presence of registered sex offenders. Using a spatial multilevel approach, the current study examines the role registered sex offenders influence sale values of homes sold in 2015 for three U.S. counties (rural, suburban, and urban) located in Illinois and Kentucky within the social disorganization framework. Homebuyers were surveyed to examine whether awareness of local registered sex offenders and the homebuyer’s community type operate as moderators between home selling …

Interaction Style Of Mothers Of Young Children With Williams Syndrome And Relations With Child Expressive Vocabulary., Danielle R. Henderson

Electronic Theses and Dissertations

Children of a given age vary widely in their expressive vocabulary abilities. One factor that is related to child expressive vocabulary ability is the style in which the mother interacts with her child. Studies that have considered this relation for either typically-developing (TD) children or children with developmental or intellectual disability (DD/ID) (e.g., autism spectrum disorder, fragile X syndrome) have shown that children whose mothers have a more sensitive/responsive interaction style have significantly larger expressive vocabularies than do children whose parents have a less sensitive/responsive style (e.g., Baker et al., 2010; Belsky et al., 2007; Brady et al., 2014; NICHD …

Estimation Of The Three Key Parameters And The Lead Time Distribution In Lung Cancer Screening., Ruiqi Liu

Electronic Theses and Dissertations

This dissertation contains three research projects on cancer screening probability modeling. Cancer screening is the primary technique for early detection. The goal of screening is to catch the disease early before clinical symptoms appear. In these projects, the three key parameters and lead time distribution were estimated to provide a statistical point of view on the effectiveness of cancer screening programs. In the first project, cancer screening probability model was used to analyze the computed tomography (CT) scan group in the National Lung Screening Trial (NLST) data. Three key parameters were estimated using Bayesian approach and Markov Chain Monte Carlo …

Likelihood-Based Methods For Analysis Of Copy Number Variation Using Next Generation Sequencing Data., Udika Iroshini Bandara

Electronic Theses and Dissertations

A Copy Number Variation (CNV) detection problem is considered using Circular Binary Segmentation (CBS) procedures, including newly developed procedures based on likelihood ratio tests with the parametric bootstrap for models based on discrete distributions for count data (Poisson and negative binomial) and a widely-used DNAcopy package. Results from the literature concerning maximum likelihood estimation for the negative binomial distribution are reviewed. The Newton-Raphson method is used to find the root of the derivative of the profile log likelihood function when applicable, and it is proven that this method converges to the true Maximum Likeihood Estimate (MLE), if the starting point …

Sphingolipids In Models Of Kidney Disease And Injury., Tess V. Dupre

Electronic Theses and Dissertations

Acute kidney injury (AKI), resulting from cisplatin, remains an obstacle in the treatment of cancer. Cisplatin-induced AKI involves cell death pathways regulated by sphingolipids such as ceramide and glucosylceramide. Results indicate that cisplatin-treated mice had increased levels of ceramide and hexosylceramide. Pre-treatment of mice with inhibitors of ceramide synthesis prevented accumulation of ceramide and hexosylceramide in the renal cortex and attenuated cisplatin-induced AKI. To determine the role of ceramide metabolism to hexosylceramides in kidney injury, we treated mice with an inhibitor of glycosphingolipid synthesis. Inhibition of glycosphingolipid synthesis attenuated the accumulation of the hexosylceramide and exacerbated ceramide accumulation in the …

Examining The Effects Of Trait Rumination On Hostile Attribution Bias, Kyle A. Suhr

Electronic Theses and Dissertations

Previous research supports the idea that individuals high in trait anger tend to experience more hostile attribution bias. According to the Integrative Cognitive Model, cognitive factors, such as rumination, may increase the risk of hostile attribution bias and any subsequent aggressive behaviors. Sex differences are apparent in rumination and anger expression. The present research explored the potential role trait rumination plays in hostile attribution bias as well as potential conditional effects of sex on this relationship. Participants were asked to complete a number of self-report measures and vignettes of ambiguously hostile situations adapted to improve reliability. Hypotheses were largely supported …

Restoring גלה Ii From Exile: Discovering The Homonyms Spelled ג-ל-ה By Examining Their Usage In The Hebrew Bible, Josiah D. Peeler

Electronic Theses and Dissertations

This thesis examines the evidence in the Hebrew Bible of the ancient Hebrew lexeme גלה. The aim is to determine how many roots are represented by the spelling ג-ל-ה in the Hebrew Bible. With the help of verbal valency theory, I examine the complementation patterns of גלה.

Previous attempts to understand the ancient Hebrew גלה focus on semantics. I challenge this approach and suggest that semantics alone is insufficient for understanding גלה (Chapter 1). Thus, I incorporate the clausal syntax of גלה with attention to גלה’s appearance in the different binyanim and the different complement patterns that accompany גלה’s different …

The Experience Of Victimization As The Result Of Cyberbullying Among College Students: A Study Of Demographics, Self-Esteem, And Locus Of Control, Sonya P. Poole

Electronic Theses and Dissertations

Cyberbullying is commonly defined as a deliberate and aggressive act that is committed using an electronic form of contact. It has been linked to negative emotional and mental well-being along with incidents of suicide. The current study looks at the prevalence rates of cyberbullying among college aged adults. It uses a survey method design to examine the correlation of cyberbullying with gender, age, race, socioeconomic status, self-esteem, and locus of control. The results indicated a relatively high report of cyberbullying incidents when compared to previous studies. A significant difference was obtained when cyberbullying incidents were evaluated based on the participant’s …

Microaggressions Towards Individuals With Learning Disability Within The College Setting, Cordava Valentina Aranda

Electronic Theses and Dissertations

Abstract

Learning disability mircroaggressions refer to the everyday verbal, nonverbal, and environmental slights and mistreatment which convey a derogatory feeling or message to individuals with a learning disability across various settings. Learning disability microaggressions may contribute significantly to the negative aspects of mental health issues often perceived in individuals with learning disabilities. The purpose of this study was to develop a microaggression scale designed to assess microaggressions displayed towards individuals with learning disabilities (LD) within the academic setting. A scale designed to assess LD microaggressions was constructed and modeled after the Racial Microaggression Scale (RMAS). A confirmatory factor analysis was …