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Putnam County, Tennessee’S Prekindergarten Program As Measured By Test Scores, Gpa, Attendance, And Discipline Reports In 3rd, 7th, And 9th Grade, Christopher J. Winningham Aug 2017

Putnam County, Tennessee’S Prekindergarten Program As Measured By Test Scores, Gpa, Attendance, And Discipline Reports In 3rd, 7th, And 9th Grade, Christopher J. Winningham

Electronic Theses and Dissertations

The purpose of this quantitative study was to determine if there is a significant difference in the academic and behavioral performance of students who had attended Putnam County’s prekindergarten program and students who qualified for, but had not attended Putnam County’s prekindergarten program. The researcher examined individual student data of specific students in three grade bands (elementary, middle, and high school). The grade levels included 3rd grade, 7th grade, and 9th grade. The data analyzed were students’ individual GPA, ACT Explore scores, MAP Universal Screener scores, number of days absent, and number of discipline referrals of students who had attended …


Role Of Tlrs, Hippo-Yap1 Signaling, And Micrornas In Cardiac Repair And Regeneration Of Damaged Myocardium During Ischemic Injury, Xiaohui Wang Aug 2017

Role Of Tlrs, Hippo-Yap1 Signaling, And Micrornas In Cardiac Repair And Regeneration Of Damaged Myocardium During Ischemic Injury, Xiaohui Wang

Electronic Theses and Dissertations

Cardiovascular disease is a leading cause of death in the United States. Toll-like receptor (TLR)-mediated pathways have been demonstrated to play a role in myocardial ischemia/reperfusion (I/R) injury. We and others have shown that PI3K/Akt signaling is involved in regulating cellular survival and protecting the myocardium from I/R induced injury. In this dissertation, we provide compelling evidence that miR-125b serves to “fine tune” TLR mediated NF-kB responses by repressing TNF-a and TRAF6 expression. We constructed lentiviral expressing miR-125b, delivered it into the myocardium. The data showed that delivery of lentivirus expressing miR-125b significantly reduces myocardial infarct size and improves cardiac …


The Perceptions Of Father Involvement In Elementary Schools, Myles J. Hebrard Aug 2017

The Perceptions Of Father Involvement In Elementary Schools, Myles J. Hebrard

Electronic Theses and Dissertations

The purpose of this phenomenological study was to understand the perceptions of father involvement in elementary schools. The focus of the study was to allow the researcher to develop a greater understanding of perceptions of father involvement, from both a father and teacher perspective. Data was collected from teachers and fathers through surveys and interviews. Specific content areas of the father survey included communication, activities fathers engaged in, training opportunities provided at the school, parent conferences, when events were offered, availability, and suggestions for school staff. Specific content areas of the teacher survey included communication, activities fathers engaged in, training …


Evaluating Effective Communication Methods: Improving Internal Communication, Amber L. Suthers Aug 2017

Evaluating Effective Communication Methods: Improving Internal Communication, Amber L. Suthers

Electronic Theses and Dissertations

Relaying information from a Chief Communications Officer (CIO), or centralized communications departments to hospital employees is not always efficient or effective. Employees may not be informed of important changes to department protocols or hospital policies. The purpose of the study was to determine the most efficient and effective forms of internal communications in the hospital setting.

A total of 83 surveys were mailed to communication officers working in Tennessee hospitals in and east of Nashville. Sixteen communication officers responded. This low response rate may be attributed to poor designation of communication responsibilities and an abdication of responsibilities to an off …


Early Childhood Adversity And Chronic Illness: An Examination Of A High Risk- Forensic Inpatient Population, Courtney L. Cook Aug 2017

Early Childhood Adversity And Chronic Illness: An Examination Of A High Risk- Forensic Inpatient Population, Courtney L. Cook

Electronic Theses and Dissertations

Individuals exposed adverse childhood experiences (ACEs) are at increased risk of developing chronic illnesses in adulthood including heart disease, cancer, diabetes, and chronic pain. A relationship between ACEs and health risk factors contributing to chronic disease such as smoking, obesity, and sedentary lifestyle has also been established in prior literature. There is evidence that higher that individuals in forensic inpatient mental health samples are disproportionally exposed to ACEs, which may increase odds of chronic disease development. Despite this evidence, little research has examined the prevalence of ACEs and relationships between ACEs and chronic health conditions and risky health behaviors in …


A Study Of Salmonid Growth In Two Southern Appalachian Headwater Streams, Joshua Argo Aug 2017

A Study Of Salmonid Growth In Two Southern Appalachian Headwater Streams, Joshua Argo

Electronic Theses and Dissertations

This study sampled salmonid populations in two headwater streams in East Tennessee, Briar Creek and Left Prong Hampton Creek. Length and weight data were used to calculate the growth of these populations to determine if significant variation exists between isolated brook trout populations. Slope comparisons concluded that there was a difference in growth between brook trout populations of these streams (p


Enemy Exacerbation: Effects Of Predator Stress On Sulfate Lethality In Freshwater Amphipods (Gammarus Minus), Trevor Chapman Aug 2017

Enemy Exacerbation: Effects Of Predator Stress On Sulfate Lethality In Freshwater Amphipods (Gammarus Minus), Trevor Chapman

Electronic Theses and Dissertations

Predator cues can influence how aquatic organisms respond to anthropogenic contaminants. This study examined the effects of predator cues on behavior, metabolic rate, and sulfate (as Na2SO4) toxicity in amphipods (Gammarus minus). Predator cues included alarm cue (macerated conspecifics) and kairomone from mosquitofish (Gambusia affinis). Amphipods decreased activity and increased time in refuge when exposed to alarm cue, and increased time in refuge when exposed to kairomone. While median lethal concentrations (96-h LC50) were not influenced by predator cues, analysis of dose response curves indicated that kairomone exposure increased amphipod …


Effects Of Acute Sepsis On Renal Structure And Sympathetic Innervation In Mice, Tuqa Alkhateeb Aug 2017

Effects Of Acute Sepsis On Renal Structure And Sympathetic Innervation In Mice, Tuqa Alkhateeb

Electronic Theses and Dissertations

Sympathetic nerves are important for renal physiology and sepsis pathophysiology. A recent study showed sprouting of sympathetic nerves in spleen of septic mice. This study was done to test if renal sprouting of sympathetic nerves also happens and to investigate renal morphology in septic mice. Cecal ligation and puncture (CLP) was used to induce sepsis and kidneys were removed for evaluation. Bowman’s space was diminished with cortical bubble cells present suggestive of acute renal pathology, however, renal function was unchanged. Acute sepsis did not affect either renal sympathetic innervation or non-neuronal cholinergic cells. Mouse kidneys had more epinephrine (EPI) than …


The Effects Of Employment On Recidivism Among Delinquent Juveniles, Leigh Kassem Aug 2017

The Effects Of Employment On Recidivism Among Delinquent Juveniles, Leigh Kassem

Electronic Theses and Dissertations

Current research indicates an association between intense adolescent work (twenty hours or more per week) and delinquent behavior. It has been widely speculated that this relationship is spurious, occurring only as a result of other factors which are common to both offending and intense employment. The current study attempts to fill a gap in the literature by utilizing the Pathways to Desistance dataset to examine the evolution of the relationship between work and self-reported offending in a longitudinal sample of juvenile offenders. Work intensity and consistency, social capital, and expectations for success were analyzed as potential predictors of recidivism or …


Effects Of Functional Communication Training And Self-Monitoring With Programmed Generalization For Three Students With Or At-Risk For Emotional Behavioral Disorders., Jonathan L. Burt Aug 2017

Effects Of Functional Communication Training And Self-Monitoring With Programmed Generalization For Three Students With Or At-Risk For Emotional Behavioral Disorders., Jonathan L. Burt

Electronic Theses and Dissertations

The use of functional assessment based interventions to address the problem behavior of students with emotional/behavioral disorders (EBD) is supported by an emerging evidence base. Few studies, however, have assessed the generality (i.e., the transfer of behavior change across settings, behavior, or students) of function-based interventions for this population. This study employed a multiple baseline across students design to evaluate setting generalization of functional communication training (FCT) with self-monitoring for three students with or at-risk for EBD. FCT yielded significant reductions in problem behavior and increased rates of appropriate attention recruitment (i.e., hand-raising) for all three participants in isolation. However, …


Revisiting Neutrophil Responses To Toll-Like Receptor 4 : Influence Of Ligand Structures And Cellular Environments., Shuvasree Sengupta Aug 2017

Revisiting Neutrophil Responses To Toll-Like Receptor 4 : Influence Of Ligand Structures And Cellular Environments., Shuvasree Sengupta

Electronic Theses and Dissertations

Neutrophils respond to bacterial LPS through Toll-like receptor 4 (TLR4), which activates or potentiates immune defensive functions and prolongs cell survival. Activation of TLR4 signaling in neutrophils is beneficial for effective clearance of LPS-bearing Gram-negative bacteria, but may also drive aberrant inflammation if not stringently regulated. The regulatory processes by which neutrophil functions are calibrated to respond appropriately to different LPS-bearing bacteria are incompletely understood. Described here are investigations that reveal an unexpected sensitivity of TLR4 in neutrophils to small changes in LPS structure typical of various Gram-negative bacteria, including those that are dangerously virulent (Escherichia coli and Salmonella …


Cumulative Trauma, Emotion Reactivity And Salivary Cytokine Response Following Acute Stress Among Healthy Women., Yvette Z. Szabo Aug 2017

Cumulative Trauma, Emotion Reactivity And Salivary Cytokine Response Following Acute Stress Among Healthy Women., Yvette Z. Szabo

Electronic Theses and Dissertations

This study furthers understanding of how trauma exposure may be connected to the development and maintenance of poor health by focusing on cytokines, tightly regulated proteins of the immune system. Cytokine responses to acute stress have been associated with the onset of poorer mental health in physically healthy women. The present study examined how two factors recently associated with cytokine reactivity –cumulative trauma and emotion reactivity– are associated with salivary cytokine reactivity among healthy women. Seventy-one women, screened to be physically and mentally healthy, completed a laboratory acute stress paradigm and self-report measures of state emotion and trauma exposure. Participants …


Engineering Applications Of Organic Surfactant Modified Bentonite In Sorptive Soil Barriers., Sadra Javadi Aug 2017

Engineering Applications Of Organic Surfactant Modified Bentonite In Sorptive Soil Barriers., Sadra Javadi

Electronic Theses and Dissertations

Earthen barriers such as CCLs and GCLs have been employed in geotechnical practices to provide a low permeability hydraulic barrier since long time ago. These types of barriers exhibited satisfactory performance for many applications such as landfills. The performance of low permeability barriers is based on the swelling potential of their component, which is mostly Na-bentonite, in contact with polar fluids such as water. However, the acceptable range of conductivity cannot be achieved by traditional earthen barriers when they are permeated by non-polar fluids such as gasoline. This phenomenon occurs due to the incompatibility of earthen barrier constituent with non-polar …


Quality And Yield Responses Of Seven Warm Season Forage Grasses To Partial Shading In A Simulated Silvopasture In East Texas, Jodi E. Hill Aug 2017

Quality And Yield Responses Of Seven Warm Season Forage Grasses To Partial Shading In A Simulated Silvopasture In East Texas, Jodi E. Hill

Electronic Theses and Dissertations

The goal of this project was to evaluate growth and nutritional characteristics of seven forages, including various warm season native grasses, grown under simulated partial shading (50%) typical of a loblolly pine silvopastoral system in East Texas. In order to meet the overall objective, slatted shade structures were constructed that simulated the quantity, quality, and overall light regime found beneath loblolly pine stands arranged for silvopasture. The forages selected for the study included ‘Tifton 9’ bahiagrass (Paspalum notatum), ‘Tifton 85’ bermudagrass (Cynodon dactylon), ‘Alamo’ switchgrass (Panicum virgatum), ‘Kaw’ Big Bluestem (Andropogon gerardii), ‘Americus’ …


An Examination Of The Workloads And The Effectiveness Of An Athlete Monitoring Program In Ncaa Division I Men's Soccer, Matthew L. Sams Aug 2017

An Examination Of The Workloads And The Effectiveness Of An Athlete Monitoring Program In Ncaa Division I Men's Soccer, Matthew L. Sams

Electronic Theses and Dissertations

The purposes of this dissertation were to examine common athlete training and monitoring practices in men’s collegiate soccer and to report the programming strategies and monitoring outcomes for an NCAA Division I men’s collegiate soccer team whose coaching and sport science staff collaborated on a daily basis. The following are the major findings of the dissertation:

Study 1 – Coaches from all divisions of play responded to a custom survey. A majority of coaches developed an in-season training plan that varied both daily and weekly volume and intensity. One-third of the coaches performed no athlete monitoring, and a number of …


Development And Validation Of The Bisexual Microaggressions Scale, Emma G. Fredrick Aug 2017

Development And Validation Of The Bisexual Microaggressions Scale, Emma G. Fredrick

Electronic Theses and Dissertations

Sexual minorities face stigmatizing experiences which can lead to disparities in physical and mental health, as well as social and economic resources. Additionally, research suggests that microaggressions, or small actions and comments that speak to a person’s prejudices, act as stigmatizing experiences and contribute to negative outcomes for the stigmatized. However, most studies of sexual minority health do not explore bisexual experiences uniquely, despite evidence that bisexuals have unique experiences of stigma and microaggressions. Those studies that do explore bisexual experiences find worse outcomes for bisexuals than their lesbian or gay counterparts. Thus, the current study developed a quantitative scale …


Mirna Expression Changes In Arsenic-Induced Skin Cancer In Vitro And In Vivo., Laila Al-Eryani Aug 2017

Mirna Expression Changes In Arsenic-Induced Skin Cancer In Vitro And In Vivo., Laila Al-Eryani

Electronic Theses and Dissertations

Arsenic is a naturally prevalent metalloid. Chronic arsenic ingestion through drinking water causes skin cancer. Arsenic-induced cancer mechanisms are not well defined. Epigenetic changes, including microRNA expression changes, might be playing a role. This dissertation investigates the impact of miRNA expression changes in arsenic-induced skin cancer. MiRNA expression was measure and compared using 3 different techniques, RTq-PCR, hybridization arrays and RNA-sequencing. MiRNAs differential expression in skin lesions was phenotype- and stage-related. Immortalized human keratinocytes (HaCaT) were transformed by chronic low arsenite exposure serving as a model for arsenic-induced skin carcinogenesis. Early changes in miRNAs and target mRNAs contribute to arsenic-induced …


Exploring The Relationship Between Physical Activity And Executive Function In Early Childhood Populations: An Investigation Of Maternal Encouragement Of Activity, Lauren P. Driggers-Jones Aug 2017

Exploring The Relationship Between Physical Activity And Executive Function In Early Childhood Populations: An Investigation Of Maternal Encouragement Of Activity, Lauren P. Driggers-Jones

Electronic Theses and Dissertations

Researchers have found positive associations between physical activity and executive function in adolescence and adulthood. However, research in early childhood has revealed only negative relationships. In the present study, I explored whether maternal encouragement of physical activity might moderate this relationship in very young children. Using video recordings from an archival dataset, eight maternal encouragement measures were derived from mother-child free play sessions. Although it was expected that maternal encouragement of child activity would broadly play a moderating role in the relationship between children’s physical activity and their executive function, only maternal questions seemed to moderate this relationship. One explanation …


Cultivar, Season Extension, Fertilizer Trials Of Swiss Chard And Pedagogy Of Assessing Cultivars Using Technology, Chanelle Angeny Aug 2017

Cultivar, Season Extension, Fertilizer Trials Of Swiss Chard And Pedagogy Of Assessing Cultivars Using Technology, Chanelle Angeny

Electronic Theses and Dissertations

Abstract. Diversity of species is a cornerstone of horticulture, and the constant stream of new plant cultivars broadens the palette of options available to the industry. Fifteen Swiss chard (Beta vulgaris var. cicla) cultivars were evaluated during the fall/winter of 2014-2015 season (season 1) and 27 cultivars during the fall/winter of 2015-2016 season (season 2) to determine the best performing cultivars for production and landscape use for east Texas and the southeast by assessing survivability and yield. There was an increase in production of 3.0 ± 0.5 g per plant per harvest under the low tunnel. The cultivar …


A Qualitative, Exploratory Case Study Of Self-Reported Influences Affecting The Decision Of Homeless Sexual-Minority Students To Leave Home, Michael P. Hill Aug 2017

A Qualitative, Exploratory Case Study Of Self-Reported Influences Affecting The Decision Of Homeless Sexual-Minority Students To Leave Home, Michael P. Hill

Electronic Theses and Dissertations

This study was designed to identify commonalities regarding influences within the decision-making process that attributed to sexual-minority students voluntarily or involuntarily becoming homeless in lieu of remaining in their respective familial home. An exploratory case-study research design was utilized to determine common themes present in the self-described events that led up to the respective decisions of three volunteer participants, who identified themselves as sexual-minority youths at the time of transition, to leave home. Results of this study discerned five commonalities among the participants’ experiences, which influenced their experiencing homelessness. The detection of these commonalities may provide school administrators and other …


How Muslims Help : An Ethnography Of Muslim Voluntary Assistance For Syrian Refugees In Louisville, Ky., Irene Levy Yates Aug 2017

How Muslims Help : An Ethnography Of Muslim Voluntary Assistance For Syrian Refugees In Louisville, Ky., Irene Levy Yates

Electronic Theses and Dissertations

This thesis examines Islamic faith-based organizations’ involvement in Syrian refugee resettlement in Louisville, KY with special attention to the impact of an Islamic Relief USA community engagement grant awarded to Kentucky Refugee Ministries in 2014. A description of local Muslim community support for newly arrived refugees was constructed via participant observation and semi-structured interviews with former and current resettlement agency employees, a diverse set of Muslim community volunteers, and refugees who participate in and/or are supported by Islamic faith-based organizations. Muslim communities in Louisville approach refugee resettlement in ways that are significantly different from both resettlement agency staff and past …


Former Students Discuss Middle School Science Journalism : A Qualitative Study Of Personally Meaningful Disciplinary Writing., Marsha R. Buerger Aug 2017

Former Students Discuss Middle School Science Journalism : A Qualitative Study Of Personally Meaningful Disciplinary Writing., Marsha R. Buerger

Electronic Theses and Dissertations

This qualitative research study explores the experiences of six middle school students with science news writing (SciJourn) after they have transitioned to high school. The qualitative method of case study was used with the data analyzed through the method of constructivist grounded theory. SciJourn is a disciplinary approach to science literacy that allows students to choose and research their own topic, interact with experts in the field, construct their own knowledge, and have the opportunity to publish in an on-line science newspaper (Scijourner.org). Theoretically, this research draws on science as social practice where literacy learning is cognitively complex, is situated …


Mental Health And Substance Use Disorders And Treatment Receipt Among Pregnant Women In The United States, 2008-2014 : Trend Analysis, Likelihood Of Treatment Receipt, And Ethnic Disparities In Mental Health Treatment., Taghreed Nayel Salameh Aug 2017

Mental Health And Substance Use Disorders And Treatment Receipt Among Pregnant Women In The United States, 2008-2014 : Trend Analysis, Likelihood Of Treatment Receipt, And Ethnic Disparities In Mental Health Treatment., Taghreed Nayel Salameh

Electronic Theses and Dissertations

The purposes of this dissertation were to examine trends from 2008 to 2014 in mental health and substance use disorders and treatment receipt, and explore factors associated with treatment receipt in pregnant women aged 18-44 years in the United States. A systematic review showed that illicit drug use disorder increased in pregnant women over the past decade. Despite the increase in treatment admissions for these disorders from 1992 to 2012, the overall treatment admission rate for pregnant women remained relatively stable (4%). In a trend study, compared mental health and substance use disorders and treatment receipt across Matched groups of …


Mitochondrial Transcription Factor A'S Role In Heart Failure., George H. Kunkel Aug 2017

Mitochondrial Transcription Factor A'S Role In Heart Failure., George H. Kunkel

Electronic Theses and Dissertations

Background: An essential mitochondrial component, Mitochondrial Transcription Factor A (TFAM) is reduced within the failing heart. TFAM maintains regulatory functions of cardiomyocyte physiology and stability. Mitochondrial Transcription Factor A forms a mitochondrial nucleoid anti-oxidant structure and reduces pathophysiological abnormalities to structural and contractile proteins. Overall, this functions to physically stabilize mtDNA. Significant molecular changes such as a loss of TFAM drive pathophysiological concentrations of cytoplasmic Ca2+ and reactive oxygen species. Both of these factors induce proteolytic enzymes to degrade the physiological cardiomyocyte. In TFAMs absence, heart function deteriorates and hypertrophic expansion ensues: thereby changing the physiological myocardium to a pathological …


Effect Of Protease Supplementation In Broiler Feed On Growth Performance, Carcass Yield And Total Nitrogen Retention In Fecal Matter And Litter, Jawad Al-Juboori Aug 2017

Effect Of Protease Supplementation In Broiler Feed On Growth Performance, Carcass Yield And Total Nitrogen Retention In Fecal Matter And Litter, Jawad Al-Juboori

Electronic Theses and Dissertations

ABSTRACT

The objectives of this study were to determine the effects of protease supplementation on commercial broiler performance, carcass yield, and nitrogen retention in fecal matter and litter. Total of 4,800 female (Ross 708) birds split into 96 floor pens, and randomly assigned to one of four treatment groups. Birds were placed within 96, 5’x10’ floor pens in a randomized-block design at the SFASU Poultry Research Center. Birds were randomly divided among the pens at a stocking density of 1.00 ft2/bird (50 birds/pen*24 pens/treatment=1200 birds/treatment), and reared for 49 days on used pine shavings. The target average weight for the …


Diversity For Diversity's Sake? The Relationship Between Diversity And School-Level Academic Achievement., Richard Aaron Wisman Aug 2017

Diversity For Diversity's Sake? The Relationship Between Diversity And School-Level Academic Achievement., Richard Aaron Wisman

Electronic Theses and Dissertations

There is contention among researchers about how to best operationalize socioeconomic status (SES). This study seeks to provide an explicit definition of one metric of socioeconomic status, the diversity index (DI) of Jefferson County Public Schools (JCPS) and investigates its efficacy at predicting the aggregate academic achievement of students within a school, relative to other common metrics of SES which are analogous to components of the DI. Another purpose of this study is to investigate possible peer effects of socioeconomic diversity on low SES students. This study utilizes a correlational – multiple regression approach to explore relationships among study variables …


Articulating The New Normal(S) : Mental Disability, Medical Discourse, And Rhetorical Action., Andrew Wesley Holladay Aug 2017

Articulating The New Normal(S) : Mental Disability, Medical Discourse, And Rhetorical Action., Andrew Wesley Holladay

Electronic Theses and Dissertations

“Articulating the New Normal(s): Mental Disability, Medical Discourse, and Rhetorical Action” studies the writing of people diagnosed with autism and post- traumatic stress disorder within online discussion boards related to mental health and outlines their unique rhetorical strategies for interacting with biomedical ideologies of psychiatry and activist discourses. The opening chapter situates this dissertation in relation to previous scholarship in Rhetoric, Disability Studies, and other fields. I also provide a summary of the set of mixed methods I use to gather and analyze my data, including rhetorical analysis, corpus analysis, and qualitative interviews. In Chapter 2, “Medical Terminology and Discourse …


Stretching Adversely Modulates Locomotor Capacity Following Spinal Cord Injury Via Activation Of Nociceptive Afferents., Anastasia V. Keller Aug 2017

Stretching Adversely Modulates Locomotor Capacity Following Spinal Cord Injury Via Activation Of Nociceptive Afferents., Anastasia V. Keller

Electronic Theses and Dissertations

Spinal cord injury (SCI) is the second leading cause of paralysis in the United States, affecting around 282,000 people with 17,000 new cases each year. Initial and secondary damage to the spinal cord disrupts multiple descending pathways that modulate the function of sympathetic preganglionic neurons and central pattern generating circuitry. Resulting loss of autonomic and locomotor functions, as well as decreased levels of physical activity, lead to a myriad of complications that affect multiple organ systems and significantly reduce both quality of life and life expectancy in individuals with SCI. Spasticity and muscle contractures are two common secondary conditions that …


Novel Processing Approaches For Thin Film Solar And Related Technologies., Brandon Lavery Aug 2017

Novel Processing Approaches For Thin Film Solar And Related Technologies., Brandon Lavery

Electronic Theses and Dissertations

A growing population along with developing nations are increasing the demand for energy. The International Energy Agency forecasts a global electricity demand increase of 70 percent by 2040. This is an increase from nearly 18 TW to over 30 TW. The sun can be a great clean source of achieving this energy demand. Despite the large solar industry development, the market is still growing as solar energy only accounted for 0.87% of the global energy production in 2013. The opportunity exists to manufacture more affordable solar energy that can penetrate more of the global energy market. In this dissertation, a …


Novel Insight Into The Liver-Lung Axis In Alcohol-Enhanced Acute Lung Injury., Lauren G. Poole Aug 2017

Novel Insight Into The Liver-Lung Axis In Alcohol-Enhanced Acute Lung Injury., Lauren G. Poole

Electronic Theses and Dissertations

Background. Individuals who chronically abuse alcohol are almost 4 times more likely to develop Acute Respiratory Distress Syndrome (ARDS), the most severe form of Acute Lung Injury (ALI), but the mechanisms by which alcohol abuse sensitizes the lung to injury are poorly understood. However, the lung appears to share many parallel mechanisms of injury with the liver- a primary target of alcohol abuse. The overarching goal of this dissertation was therefore to expand on established mechanisms of alcohol-induced liver injury to ask innovative questions about mechanisms of alcohol-enhanced acute lung injury, as well as to develop new tools that may …