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Alpha-Amino Methylation And Acetylation Are Novel Regulators Of Myl9 Function., Christopher David Nevitt

Electronic Theses and Dissertations

Dysregulation of alpha-amino post-translational modifications (Nα-PTMs) is found in multiple cancers and developmental disorders. However, the exact roles Nα-PTMs play in regulating protein function remain poorly understood. I sought to clarify the role of Nα-methylation and Nα-acetylation in the regulation of Myosin Regulatory Light Chain 9 (MYL9). MYL9 is a key cytoskeletal regulator and transcription factor and is the first protein confirmed to undergo both Nα-methylation and Nα-acetylation. Through this work I revealed novel regulatory features of MYL9, while also presenting a framework by which to understand the coordinated regulation of proteins by Nα-methylation and Nα-acetylation. Nα-PTM selective mutants of …

Race In Predominately White Schools : Implications For School Counselors., Katelyn Marie Gosnell Richey

Electronic Theses and Dissertations

This study examined the phenomenon of white school counselors and the discussions about race that occur at predominately white schools. Research in the area of predominately white schools and discussions about race is severely lacking (Chandler, 2009; Chandler & McKnight, 2009). Additionally, many researchers and authors reported that conversations about race are either avoided or poorly managed in K-12 schools (Brown & Brown, 2010; Chandler & McKnight, 2009; Lintner, 2004; Burrell & Walsh, 2001; ; Loewen, 2007; Zimmerman, 2004). This points to an even greater importance on school counselors cultivating these conversations with the students at the schools in which …

Understanding The Relationship Between Positive Affect And Cortisol In Lung Cancer Patients., Lauren Ann Zimmaro

Electronic Theses and Dissertations

Positive psychobiological processes within lung cancer patients are drastically understudied. This dissertation explores the nature of positive affect (PA) and potential associations with diurnal cortisol among lung cancer patients, given the prognostic significance of diurnal cortisol rhythms. Theoretical underpinnings and current literature involving PA, cancer, and diurnal cortisol are first reviewed. An original integrated model of PA and cortisol among cancer patients is then presented, from which the proposed dissertation study and analyses are derived. Sixty-one non-small cell lung cancer patients provided self-report assessment of mood (PANAS PA and NA subscales, CES-D PA subscale), medical and demographic characteristics, and 10-day …

Coal Ash Exposure And Behavioral Impairments Among Children In Louisville, Kentucky., Chisom Nmesoma Odoh

Electronic Theses and Dissertations

Introduction: Coal ash, generated from the combustion of coal is principally made up of fly ash, which consists of small particles and metals that can affect the development of children. Coal ash is predominately stored in landfills and surface impoundments, of which many are in proximity to residential areas. According to the Environmental Protection Agency, 25% of residents in proximity to electric power plants are children. Few studies have reported a positive association between coal ash and its by-products and neurobehavioral disorders. The purpose of this study was to explore the relationship between coal ash and its components and …

Generalized Spatiotemporal Modeling And Causal Inference For Assessing Treatment Effects For Multiple Groups For Ordinal Outcome., Soutik Ghosal

Electronic Theses and Dissertations

This dissertation consists of three projects and can be categorized in two broad research areas: generalized spatiotemporal modeling and causal inference based on observational data. In the first project, I introduce a Bayesian hierarchical mixed effect hurdle model with a nested random effect structure to model the count for primary care providers and understand their spatial and temporal variation. This study further enables us to identify the health professional shortage areas and the possible impacting factors. In the second project, I have unified popular parametric and nonparametric propensity score-based methods to assess the treatment effect of multiple groups for ordinal …

Canonical Nuclear Factor-Κb Signaling In Satellite Stem Cell Homeostasis And Function., Alex R. Straughn

Electronic Theses and Dissertations

Satellite cells are adult stem cells that are required for the regeneration of skeletal muscle following injury. However, the signaling mechanisms that regulate satellite stem cell homeostasis and function in adult animals remain less understood. Nuclear factor-kappa B (NF-kB) is a major nuclear transcription factor that regulates the gene expression of a plethora of molecules involved in cellular proliferation, differentiation, survival, and the inflammatory immune response. NF-kB can be activated through a canonical or non-canonical pathway. However, the role of canonical NF-kB signaling in the regulation of satellite stem cell function during skeletal muscle regeneration has not been yet investigated …

High Dynamic Range Optical Devices And Applications., Elijah Robert Jensen

Electronic Theses and Dissertations

Much of what we know about fundamental physical law and the universe derives from observations and measurements using optical methods. The passive use of the electromagnetic spectrum can be the best way of studying physical phenomenon in general with minimal disturbance of the system in the process. While for many applications ambient visible light is sufficient, light outside of the visible range may convey more information. The signals of interest are also often a small fraction of the background, and their changes occur on time scales so quickly that they are visually imperceptible. This thesis reports techniques and technologies developed …

Evaluation Of Drug-Loaded Gold Nanoparticle Cytotoxicity As A Function Of Tumor Tissue Heterogeneity., Hunter Allan Miller

Electronic Theses and Dissertations

The inherent heterogeneity of tumor tissue presents a major challenge to nanoparticle-medicated drug delivery. This heterogeneity spans from the molecular to the cellular (cell types) and to the tissue (vasculature, extra-cellular matrix) scales. Here we employ computational modeling to evaluate therapeutic response as a function of vascular-induced tumor tissue heterogeneity. Using data with three-layered gold nanoparticles loaded with cisplatin, nanotherapy is simulated with different levels of tissue heterogeneity, and the treatment response is measured in terms of tumor regression. The results show that tumor vascular density non-trivially influences the nanoparticle uptake and washout, and the associated tissue response. The drug …

The Role Of Hardiness In The Relation Between Perceived Daily Discrimination And Depressive Symptoms In Community College Students., Rosamond J. Smith

Electronic Theses and Dissertations

In the current study, perceived daily discrimination (PDD) is conceptualized as a chronic stressor which repeatedly activates a stress response and results in depressive symptoms, per the theory of allostatic load. Psychological hardiness is explored as a potential moderator of the relation between PDD and depressive symptoms, because individuals who repeatedly demonstrate hardiness may be primed for making cognitive reappraisals of potential stressors and/or for mobilizing appropriate coping strategies, thus limiting the body’s repeated stress responses and subsequent depressive symptoms. This cross-sectional survey of a diverse sample of 305 community college students included measures of hardiness (Dispositional Resilience Scale, …

Perinatal Nicotine With Or Without Early Life Influenza Infection Leads To Lung Dysfunction With Age., Ryan Carroll Mcallister

Electronic Theses and Dissertations

Obstructive Airway Diseases (OADs) affect millions of people worldwide, and are characterized by chronic inflammation and tissue remodeling in the lung. It has been proposed that the development of OAD is greatly influenced (and perhaps pre-determined) by early life events, such as maternal smoking or a viral infection. However, direct evidence of this is limited and the mechanisms involved remain unclear. Our laboratory previously developed a murine model of perinatal nicotine exposure, and reported that nicotine leads to airway remodeling and decreased pulmonary function in the offspring. We discovered these effects were mediated through the α7 nicotinic acetylcholine receptor (nAChR). …

An Examination Of The Linkages Between Climate, Engagement, And Wellbeing In Higher Education., Ebo Kobena Atomo Osam

Electronic Theses and Dissertations

Research coalescing around psychological climate, engagement, and wellbeing has been receiving considerable attention in management and HRD literature recently. However, research associated with these variables has generally been limited to for-profit businesses and organizations with little of note done using higher educational institutions. Thus, this cross sectional research study examined the extent to which psychological climate, engagement, and wellbeing are associated with each other in higher educational institutions. The study begins with an overview of how these variables have been identified as being connected with each other in research and practice, as well as discusses context specific factors in higher …

First Semester Academic Functioning Of College Students : The Role Of Stressful And Traumatic Life Events., Ashlee J. Warnecke

Electronic Theses and Dissertations

A large number of the nearly 20 million students who were attending American colleges in 2015 will not graduate. One factor that may affect the success of students is the influence of past experiences, including past adversity, or exposure to traumatic or non-traumatic stressors. The present study sought to better describe and understand the role of stress/trauma history in college students from low socioeconomic backgrounds. The potential relationship this history has with academic outcomes was explored. Additionally, as not all students with a history of stressful and traumatic life events struggle academically, self-reported resilience, as well as resiliency factors, were …

Does Rumination Mediate The Relationship Between Everyday Discrimination And Blood Pressure?, Sarah J. Roane

Electronic Theses and Dissertations

Social stressors, such as perceived discrimination, account for some health disparities by triggering a series of physiological responses (Selye, 1955) which may be prolonged by perseverative cognition such as rumination (Brosschot et al., 2005). In the current study, I investigated whether everyday discrimination is positively associated with both brooding or reflection rumination in Black/African American (AA) individuals, as well as whether brooding or reflection rumination mediate the potential associations between everyday discrimination and blood pressure. Data were collected from a community college sample and analyses were conducted using the whole sample (N = 286; 57.3% female; 51.6% White and 29.8% …

Cross-Validation Of The Body Compassion Scale In A Sample Of Women In Perimenopause., Jennifer K. Altman

Electronic Theses and Dissertations

This study is a cross-validation of the Body Compassion Scale (BCS) to confirm its factor structure and to assess concurrent validity in women in perimenopause. Body compassion is a construct developed by the author referring to the level of compassion with which an individual relates to her body. It is based in contemporary mindfulnessand acceptance-based conceptual models. The body is central to the experience of women in perimenopause. Moreover, this important transition has been largely medicalized— with little attention given to experiential aspects of this natural phase of life. A total of 281 women in perimenopause completed online questionnaires assessing …

A Clinically Relevant Mouse Model Of Cisplatin-Induced Kidney Injury., Cierra Nichole Sharp

Electronic Theses and Dissertations

Cisplatin is a potent chemotherapeutic used for the treatment of many solid cancers, including testicular, ovarian, and lung cancer. Cisplatin causes many adverse side effects, of which nephrotoxicity leading to acute kidney injury is dose-limiting. Approximately 30% of patients will develop nephrotoxicity with cisplatin, and will either have their next dose of cisplatin lowered, skipped, or be switched to a less nephrotoxic chemotherapeutic altogether. These outcomes are not ideal when trying to treat cancer. Previously, it was believed that patients could recover from cisplatin-induced acute kidney injury with little to no lasting effects, but recent longitudinal studies have shown this …

Examining The Temporal Directionality Between Teaching Behavior And Affect In High School Students., Bridget Cauley

Electronic Theses and Dissertations

Previous empirical studies demonstrate a cross-sectional association between teaching behaviors and students’ positive and negative affect and depressive symptoms. However, only one study comprised only of middle school students has examined the temporal direction of these associations, meaning the temporal direction of associations for high school students remains unclear. Therefore, this two-wave study with high school students investigated the temporal direction of the associations between teaching behaviors and students’ positive and negative affect. Participating students from one public high school (N = 188; 88.8% White; 69.7% female) completed the Teaching Behavior Questionnaire and the Positive Affect and Negative Affect …

Self-Monitoring To Increase On-Task Behavior Using The Motivaider®, Connie Summey

Electronic Theses and Dissertations

Teachers often need simple ways to implement effective classroom interventions that reduce off-task behaviors for students with or without ADHD (Gaastra, Groen, Tucha, & Tucha, 2016). One intervention that is easy to use and can be implemented with minimal demand on teachers is self-monitoring (Amato-Zech, Hoff, & Doepke, 2006). One prompt that can be used in the classroom for self-monitoring is the MotivAider. The MotivAider is an electronic timer that vibrates to provide a tactile prompt to self-monitor (Amato-Zech et al., 2006). The purpose of this study was to examine the extent to which the MotivAider, a tactile self-monitoring device, …

Modeling The Innovation Ecosystem And Development Of A Dynamic Innovation Index, Henriette Schoen

Electronic Theses and Dissertations

The topic of innovation currently generates a tremendous amount of interest around the world. Innovation is considered an essential part of the solution to creating more jobs and improving the socio-economic conditions of many countries around the globe. Innovation comes about through the existence of many interrelated solutions to socio-economic problems in an extensively interconnected network, which create value for each other. Such a complex creativity and innovation value-creating network is here called an Innovation Ecosystem (IE). The main objective of this dissertation research is to improve the current understanding of the IE by developing a simulation model that uses …

Methods For Online Feature Selection For Classification Problems, Alaleh Razmjoo

Electronic Theses and Dissertations

Online learning is a growing branch of machine learning which allows all traditional data mining techniques to be applied on an online stream of data in real-time. In this dissertation, we present three efficient algorithms for feature ranking in online classification problems. Each of the methods are tailored to work well with different types of classification tasks and have different advantages. The reason for this variety of algorithms is that like other machine learning solutions, there is usually no algorithm which works well for all types of tasks. The first method, is an online sensitivity based feature ranking (SFR) which …

Comparison Of A Modified And Traditional Rapid Infiltration Basin For Treatment And Control Of Nutrients In Wastewater Effluent, Jessica Cormier

Electronic Theses and Dissertations

Rapid infiltration basins (RIB) have been historically used in Florida for groundwater recharge, effluent disposal, or a combination of both. However, this technique has proven ineffective in providing nitrogen control unless the RIB is modified in some manner. In this study, a traditional RIB was compared to a modified RIB constructed with manufactured biosorption activated media (BAM) to evaluate nitrate removal from reclaimed water. The RIBs are used for reclaimed and excess storm water disposal. Few, if any, studies have been published where BAM-modified RIBs have been used for this purpose. In this work, a mixture of clay, tire crumb, …

The Population Ecology And Behavior Of The Cave Salamander, Eurycea Lucifuga (Rafinesque, 1822)., Joseph Gavin Bradley

Electronic Theses and Dissertations

The Cave Salamander, Eurycea lucifuga (Rafinesque, 1822), is a little-known species, yet a common inhabitant of caves in the eastern United States. Salamanders are often important components of ecological communities and ecosystems, influencing critical processes such as nutrient cycling and community composition through their predation on invertebrates. Cave-dwelling salamanders such as E. lucifuga may thus appreciably influence the relatively simple ecosystems and communities of caves. Any such influence may be particularly important because these habitats and the organisms that reside in them are often of conservation concern. I used non-invasive methods to study the demographics, movements, and habitat selection of …

A Study Of The Purpose And Value Of Recess In Elementary Schools As Perceived By Teachers And Administrators, Vickie Beard

Electronic Theses and Dissertations

Children spend at least seven and a half hours or 46.9% of their waking hours in the school setting, which brings a unique responsibility to schools (Beighle, Erwin, Morgan, & Alderman, 2012). School systems are expected to educate children according to adopted state standards and encourage a healthy, active lifestyle. The concept then is to increase knowledge by putting focus on academic achievement as well as promoting good citizenship by developing children’s social, emotional, and physical development, which happens during recess. Yet, recess and free play opportunities are on the decline in school systems across our nation. This reduction or …

Location Matters: A Geospatial Analysis Of Principal Turnover In The Denver Metropolitan Area, Lorna O. Beckett

Electronic Theses and Dissertations

Research indicates that principals leave their school on average every three years. Additional research is needed to understand factors that are related to principal turnover. In this study I used geographic information systems to examine the geospatial variance between school characteristics, student achievement, and principal turnover in the Denver metropolitan area. I found that principal turnover is an issue in both urban and suburban areas, with suburban areas in the Denver metropolitan area experiencing similar trends in principal turnover. In this study I also highlight the importance of understanding local context when examining principal turnover patterns.

Navigating Mental Health Care Access In Louisville : An Ethnography Of Local Resources And Care Assemblages., Laura Drabelle Valentine

Electronic Theses and Dissertations

This thesis examines barriers to care access present in Louisville, Kentucky's community mental health care infrastructure, and how individuals who seek mental health care experience and navigate those barriers. This thesis expands research about the impacts of health care reform following the Affordable Care Act and adds to literature about the political economy of health-seeking behaviors. Drawing on assemblage theory and ethnographic research with both care-providers and care-recipients of Community Mental Health Care Organizations, I argue that both groups attempt to alleviate barriers to care access and facilitate mental health recovery through the development of formal and informal strategies. Examining …

Combination Oral Immunotherapy With Il-10 And Il-12 Effectively Treats Colon Tumors Via Synergistic Effects On Il-17 Producing T Cells And Colon Epithelial Barrier Integrity., Neal Bhutiani

Electronic Theses and Dissertations

In this dissertation, the relationship between colon cancer and inflammation, the utility of novel imaging modalities for diagnosis of colitis and cancer, and the therapeutic efficacy of orally delivered, particle-based immunotherapy for the treatment of colon cancer are evaluated. In Chapters One and Two, multispectral optoacoustic tomography (MSOT) is demonstrated to effectively detect colon inflammation without the use of exogenous contrast prior to detection using conventional colonoscopy. Oral particle uptake is demonstrated in the distal small intestine and proximal colon, confirming site-specific delivery. In Chapter Three, administration of IL-10 and IL-12 containing particles is shown to act synergistically to significantly …

Hybrid Perovskite Characterization And Device Applications., Kasun Fernando

Electronic Theses and Dissertations

Hybrid perovskites are a group of materials that has shown a great impact in the field of scientific research in the past decade due to the efficiency gain within a short period of time. Hot casting is one technique that has been producing high efficient and stable solar cells. Electrical transportation of lateral device structure by such film is explored to understand basic properties and predict possible device applications using it. Under dark, memristive ability of the film was explored using various experiments. Unique uni-polar memristor ability was observed. Using the experimental results, a model is hypothesized using the concepts …

Using Reality Therapy In Clinical Supervision : A Psychotherapy-Driven Model., Quentin Hunter

Electronic Theses and Dissertations

Clinical supervision is the signature pedagogy of counseling, with most professional counselors engaging in some type of supervision during their careers (Bernard & Goodyear, 2014). Psychotherapy-based models of supervision are the oldest models, originally intended to train supervisees to practice a specific psychotherapy (e.g., psychodynamic, behavioral; Watkins & Scaturo, 2013). Pearson (2006) indicated that contemporary clinical supervision could be informed by both the research in the role of development in clinical supervision and the tenets of a theory of psychotherapy. Although Pearson (2006) provided a conceptualization of psychotherapy-driven models of supervision, there is little research into the efficacy of such …

Transgender And Racial Identities Negotiation Processes Of Transgender Asians, Asian Americans, And Pacific Islanders : A Transcendental Phenomenological Examination., Jayden Thai

Electronic Theses and Dissertations

While the field of transgender (trans) research is vastly growing and expanding, little is known about the process in which trans Asian and Pacific Islanders (API) individuals experience, navigate, and negotiate their trans and API cultural identities. The aims of this study were to: 1) examine the navigation and negotiation process for trans API individuals related to their cultural identities and values; 2) enhance, enrich, and diversify existing trans and API literature by generating foundational and complex understanding of trans API identity processes; and 3) challenge hegemonic narratives regarding trans API individuals’ lived experiences. Moustakas’ (1994) transcendental phenomenological qualitative methodology …

Using Finite Element Output To Detect Damage In A Steel Frame Model, Ai D. Nguyen

Electronic Theses and Dissertations

Many structural collapses, all over the world, are related to inspection errors. The U.S. I- 35 Bridge in Minneapolis and the Canterbury Television building in New Zealand are a few examples. U.S. infrastructure conditions are poor, scoring a D+ according to ASCE report 2017. When the structures are inspected, the cost is high and service is lost. Inspectors use their trained but subjective judgment, which can lead to errors. Improved inspection techniques are required to reduce the cost, time, and subjectivity.

SHETM (Structural Health EvaluationTM) is an in-house software that has the ability to employ data to improve damage detection …

A Framework For Assessing Sustainability Impacts Of Truck Routing Strategies, Haluk Laman

Electronic Theses and Dissertations

The impact of freight on our transportation system is further accentuated by the fact that trucks consume greater roadway capacity and therefore cause more significant problems including traffic congestion, delay, crashes, air pollution, fuel consumption, and pavement damage. Assessing the actual effects of truck traffic is a growing need to support the ability to safely and efficiently move goods and people in areas where roadway expansion is not the best option. On one hand, trucks need to efficiently serve commerce and industry, while at the same time their activities need not contribute to a decline in the quality or public …