How Colonization Impacts Identity Through The Generations: A Closer Look At Historical Trauma And Education, Michelle Garcia-Olp

Electronic Theses and Dissertations

Through the lived experiences of 26 New Mexicans, this inquiry investigates how colonization impacts identity through the generations, particularly looking at historical trauma and education. The findings demonstrate the importance of decolonizing spaces within educational settings. Furthermore, the findings demonstrate the need for viewing educational systems and spaces through a Tribal Critical Race Theory (TribalCrit) and Indigenous Storywork lens that lead Indigenous students in finding face (one’s identity), finding foundation (one’s greatest potential/full expression) and finding heart (one’s flow with the creator). The lens of TribalCrit enables the creation of a space where Indigenous students are empowered by their educational …

Sexual Assault And Health: Understanding The Interplay Of Trauma-Related Appraisals And Physical Health Outcomes, Kerry Lyn Gagnon

Electronic Theses and Dissertations

Women who have been sexually assaulted are at risk for negative mental and physical health outcomes; however, limited research has tested how psychological responses to sexual assault may influence physical health. The present study tested a longitudinal model examining the association between posttrauma appraisals and physical health problems. Drawn from a larger study, the sample included 156 ethnically diverse women who had been sexually assaulted within the last year. The study used cross-lagged panel models to test for reciprocal relationships between posttrauma appraisals and physical health problems over time. A secondary aim of the study was to test whether other …

Agreeing To Submit: Authority Constructions In Modern Sunni Islam, Trevor E. Wolff

Electronic Theses and Dissertations

In the modern age, Sunni communities are often claimed to be in a moment of crisis. However, despite outward arguments about this crisis, Sunni communities are more accurately described as within a state of transformation. By analyzing constructions of authority from Sayyid Qutb, the clerical establishment of Saudi Arabia, and the greater American Muslim communities, Sunni theology is best seen as seeking out methods to transform and re-center authority within Sunni communities.

Attachment Theory As A Framework For Supervision Of Supervisors-In-Training, Alyssa Fredricks

Electronic Theses and Dissertations

This focus of the study is on the training of new clinical supervisors in health service psychology, specifically the relational processes involved in learning and acquiring competence in clinical supervision. An effective learning environment is critical to supervisor training and development (Borders et al., 2014;Watkins, Budge, & Callahan, 2015) and attachment theory provides a framework for understanding the complex relationship domains and group dynamics inherent to group supervision. Given the recognition that the supervisory alliance is central to the process of competent supervision (APA, 2015), the purpose of this study is to explore the relationship between adult attachment style, the …

Predicting Help-Seeking Attitudes And Intentions In A Diné Sample, Chesleigh N. Keene

Electronic Theses and Dissertations

The purpose of the study was to investigate the relationship between cultural factors, psychological distress, barriers, and attitudes toward seeking psychological help among Diné tribal members. This study is in response to calls to consider psychological and cultural factors in the underutilization of mental health services by ethnic minorities. The present study examines psychological and cultural antecedents to seeking professional psychological help among Diné tribal members (N=119). It examined the mediating role of attitudes toward help seeking in the relationship between psychological distress, barriers to care, three acculturation variables, and intentions to seek counseling. Mediation was assessed with …

College Athletes And Romantic Relationship Conflict: The Moderating Effects Of Sport-Relationship Conflict And Enrichment, Keaton Clauss Muzika

Electronic Theses and Dissertations

Relationships that college athletes develop outside of their sports have the potential to positively and negatively impact sport, relationship, and mental health outcomes. Existing research focuses on the importance of the coach-athlete, parentathlete, and athlete-athlete dyads and suggests that these relationships affect athletes’ satisfaction and commitment to sport. However, few studies examine the influence of romantic relationships on these outcomes. This study, which is founded on work-family conflict and enrichment theories, used an experimental design to examine the moderating effects of sport-relationship conflict and enrichment on the relationship between romantic relationship conflict and athlete burnout, sport commitment, depression, and perceived …

Thriving With Down Syndrome: A Qualitative Multiple Case Study, Talia G. Thompson

Electronic Theses and Dissertations

Down syndrome (DS) is a chromosomal abnormality associated with intellectual disability (ID) and multiple medical complications. However, despite significant deficits related to the disability, there are people with DS who are thriving in our community. This dissertation examines those who thrive with DS and the individual and environmental factors that influence their thriving within two manuscripts. Manuscript One presents a synthesis of seminal and current positive psychology and disability studies literature. Review indicates that thriving with ID occurs when individuals report (a) a healthy transactional relationship between the individual and the ecological system; (b) high subjective well-being; and, (c) an …

Electrochemical Microsensors For In Situ Monitoring Of Chemical Compounds In Engineered And Natural Aquatic Systems, Jared Church

Electronic Theses and Dissertations

The adaption of needle-type electrochemical microsensor (or microelectrode) techniques to environmental science and engineering systems has transformed how we understand mass transport in biotic and abiotic processes. Their small tip diameter (5-20μm) makes them a unique experimental tool for direct measurements of analytes with high spatial and temporal resolutions, providing a quantitative analysis of flux, diffusion, and reaction rate at a microscale that cannot be obtained using conventional analytical tools. However, their applications have been primarily limited to understanding mass transport dynamics and kinetics in biofilms. With the advancement of sensor fabrication and utilization techniques, their potential applications can surpass …

Exploring An Outdoor Experiential And Pyd Program's Influence On Youth In A Residential And Day Treatment Program, Rebecca Durbahn

Electronic Theses and Dissertations

This dissertation explores the process and examines the outcomes of youth participating in a positive youth development adventure-based intervention Challenge By Choice (CBC) with outcomes of youth receiving treatment as usual in a residential and day treatment program. This dissertation aims to build on the growing body of literature on outcomes associated with PYD theoretical models and AET approaches. Specifically, the proposed dissertation asks: Is there a difference in externalizing behavioral outcomes for youth who participate in CBC as compared to peers of similar age/behavioral baseline who receive only treatment as usual?

To answer this research question, a mixed methods …

Macromolecule Loading On Plga Particles Through Surface Adsorption, Yiwei Wang

Electronic Theses and Dissertations

The advent of biotherapeutics have impacted the ways in which diseases are treated. In many instances development of recombinant proteins and oligonucleotides into therapeutics are slowed by poor stability of the candidate drugs. Progress has been made in using polymeric particles as carriers of macromolecule drugs. Historically the method is to encapsulate biological drugs into spherical polymeric matrices. Owing to its biocompatible and biodegradable nature, poly (d,l-lactic-co-glycolic acid) (PLGA) has been used extensively in formulating biological drugs into nano- and micro-sized particles. The development of PLGA biologic formulations, however, has been hampered by matrix acidification; the hydrolysis of the polymer …

Increasing Access To High-Impact Practices: A Case Study On Internships At The University Of Mississippi, Jennifer Saxon, Kristina Phillips

Electronic Theses and Dissertations

This dissertation-in-practice case study aimed to assess internships opportunities at the University of Mississippi (UM) to determine potential barriers for access among African American students and students with low socioeconomic backgrounds. Internships are a high impact practice, as identified by the American Association for Colleges and Universities (AAC&U) that provide students with tangible, real-world experience to prepare for careers after graduation. Experiential learning theories (Kolb, 1984; Dewey, 1938) and high-impact practices (Kuh, 2008) establish the importance of student engagement outside of traditional classroom settings. The patterns and frequency of internship participation are not clear for University of Mississippi students. Research …

Egfr Signaling From The Early Endosome., Julie A. Gosney

Electronic Theses and Dissertations

The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase that is an integral component of proliferative signaling. When activated by a ligand at the plasma membrane, EGFR dimerizes with another ErbB family receptor, leading to kinase domain activation and transphosphorylation of C-terminus tyrosine residues. These phosphotyrosines act as crucial regulators of EGFR signaling as effector proteins dock to the receptor at these sites. The receptor undergoes clathrin-mediated endocytosis into early endosomes, where it can then be trafficked to a lysosome for degradation. However, the kinase domain of EGFR retains its activity during trafficking, suggesting that EGFR can continue …

Fostering Positive Emotion Through Self-Compassion In Individuals With Chronic Pain., Melissa E. Ellsworth

Electronic Theses and Dissertations

Previous research in chronic pain has established that reducing or removing negative aspects of functioning, such as negative emotion, maladaptive thoughts and behaviors are associated with better outcomes in this population. More limited is the research on the role of positive aspects of functioning in those with chronic pain, specifically exploring the benefits of positive emotion and how this can be bolstered in individuals with chronic pain. Limited research to date has explored strategies to promote positive aspects of functioning, including savoring, gratitude, and mindfulness, but even more limited is research exploring the role of self-compassion as a resource for …

A Structural Equation Analysis Of The Relationships Between Ptsd, Depressive Symptoms And Suicidal Ideation : Is General Strain Theory A Viable Framework For Explaining Suicide Risk Among Correctional Staff?, Wm. Clay Johnson

Electronic Theses and Dissertations

There is a large body of evidence, which suggests PTSD is strongly related to increased suicide risk, however, some studies suggest the true nature of their relationship is better explained through the development of depression due to the effects of PTSD. While a majority of the studies examining this relationship focus only on general populations, a growing body research suggests that high-risk occupations such as police, firefighters and correctional staff are developing PTSD at rates as high as 8 to 10 times that of the rate of these general samples. This study, then, aims to fill a small gap in …

Cannabidiol Alters The Immune Response To Porphyromonas Gingivalis In Mice., Shilpa Singh

Electronic Theses and Dissertations

Background: Porphyromonas gingivalis is an important etiologic agent of chronic periodontitis, an infectious disease defined by destruction of supporting tissues of the teeth. Marijuana is a risk factor for chronic periodontitis, although underlying mechanisms are poorly understood. As phytocannabinoids have been ascribed antiinflammatory properties, we hypothesized that cannabidiol exposure would lead to altered immune response to P. gingivalis infection facilitating bacterial persistence and, subsequently, increased alveolar bone loss in cannabidiol (CBD)-exposed mice. Methods: P. gingivalis-infected cannabinoid receptor 2 (CB2) knockout and wild type C57/Bl6 mice were exposed, or not exposed, to cannabidiol. Oral swabs from mice were used to monitor …

Uncertain Certainties: An Analysis Of The American Response To The 2014-2016 West African Ebola Epidemic., Kelly Carty

Electronic Theses and Dissertations

This project examines the construction of scientific facts surrounding the 2014-2016 West African Ebola outbreak as well as the subsequent uptake and transformation of those facts by the United States government. While the Ebolavirus ravaged the communities of Sierra Leone, Liberia, and Guinea, the incidence of the virus in other countries was very low. Nonetheless, the United States spent $576 million on domestic preparedness and response. This study addresses this mismatch in the context of the reinvigorated interest among rhetoricians into writing and science. Applying and expanding the methodology of Jeanne Fahnestock, this study analyzes Ebola-related statements in scientific articles, …

Post-Diagnosis Quality Of Life And Mortality In Non-Hispanic White And Hispanic Women Diagnosed With Invasive Breast Cancer., Delvon T. Mattingly

Electronic Theses and Dissertations

The prevalence of breast cancer is increasing, and the health-related quality of life (HRQOL) of breast cancer survivors may help to further understand survivorship. This study evaluated HRQOL as a potential prognostic factor for mortality among Non-Hispanic White (NHW) and Hispanic women diagnosed with invasive breast cancer. Data were used from the Health, Eating, Activity, and Lifestyle (HEAL) Study. Data for 351 participants were analyzed for associations between HRQOL scores (subscale, component) and mortality. Cox proportional hazards regression was conducted to assess the relationship between HRQOL and mortality outcomes (all-cause, breast cancer-specific, non-cancer). Median follow-up time from HRQOL assessment (approximately …

Wnt/Β-Catenin Mediated Cancer Stem Cell Activation In Hepatocellular Carcinoma., Harshulkumar M. Pandit

Electronic Theses and Dissertations

Hepatocellular carcinoma (HCC) is one of the deadliest cancers, with variable presentation, high chemotherapy resistance and early tumor recurrence. In this dissertation, we have systematically enriched, identified and characterized HCC cancer stem cells (CSCs) from 3 different HCC cell lines (Hepa1-6, HepG2, and Hep3B) using in vitro serum-free culture method. Enriched spheroids acquired CSC properties, primarily self-renewal capability, spheroid formation ability, and drug resistance. Heterogeneous CSCs enriched from Hepa1-6 cells demonstrated higher tumor initiation and proliferation capability in vivo, compared to control HCC cells in orthotopic immunocompetent mouse model. EpCAM+ CSCs were significantly enriched within heterogeneous Hepa1-6 CSC spheroids. Consequently, …

Social Determinants Of Health And A Grounded Mixed-Methods Approach To Explain Declining Life Expectancy In Eastern Kentucky : 1980 – 2014., William Renda

Electronic Theses and Dissertations

Trends in life expectancy for the United States from 1980-2014 suggest general improvement overall. However, eastern Kentucky stands out with a cluster of counties experiencing declining life expectancy. Given that life expectancy is an excepted indicator of overall population health, this anomaly in eastern Kentucky warrants investigation. This thesis uses a grounded mixed methods approach to explore this trend across the greater Appalachian region. Content and discourse analysis of interviews with public health and medical professionals in the study area revealed key themes perceived as being related to declining life expectancy, which informed variable selection for regression analysis. Regression models …

The N-Terminal Methyltransferase Homologs Nrmt1 And Nrmt2 Exhibit Novel Regulation Of Activity Through Heterotrimer Formation., Jon David Faughn

Electronic Theses and Dissertations

Protein, DNA, and RNA methyltransferases have an ever-expanding list of novel substrates and catalytic activities. Even within families and between homologs, it is becoming clear the intricacies of methyltransferase specificity and regulation are far more diverse than originally thought. In addition to specific substrates and distinct methylation levels, methyltransferase activity can be altered through formation of complexes with close homologs. This work involves the N-terminal methyltransferase homologs NRMT1 and NRMT2. NRMT1 is a ubiquitously expressed distributive trimethylase. NRMT2 is a monomethylase expressed at low levels and in a tissue-specific manner. They are both nuclear methyltransferases with overlapping target consensus sequences …

A Cancer-Targeted Gold Nanoparticle-Based Mri Contrast Agent., Nagwa El-Baz

Electronic Theses and Dissertations

In oncology, imaging plays a major role in terms of early detection and treatment of most types of cancer. Magnetic resonance imaging (MRI) is mostly used for cancer diagnosis due to its excellent contrast resolution. However, MRI for cancer diagnosis is somewhat limited by its sensitivity. In this thesis, we assessed the ability of theranostic platform consisting of gold nanoparticles functionalized with a cancer targeting aptamer; AS1411 and gadolinium chelate (Dotarem thiol derivative; Gd (III)-DO3A) as a MRI contrast agent to target malignant tumors by enhancing the MRI contrast of the detected tumor. The proposed technology is a novel injectable …

Macro-Level Predictors Of Assaults Against Police In Kentucky., Virginia Paulette Redman

Electronic Theses and Dissertations

Law enforcement is one of the most dangerous careers. Every day, while performing their jobs, police officers may find themselves in situations that place them at a high risk of being victimized or even feloniously killed by members of the public. Over the past five decades, several quantitative and qualitative research studies tried to identify the circumstances and the individual-level factors associated with an increased risk of police victimization. While most of the research studies focusing on police victimization were descriptive and/or were based on micro-level analyses, macro-level research on this topic is relatively scant. This dissertation intends to reduce …

A Novel Fibroblast Growth Factor 1 Variant Reverses Nonalcoholic Fatty Liver Disease In Type 2 Diabetes., Qian Lin

Electronic Theses and Dissertations

Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disorder and is strongly associated with type 2 diabetes (T2D). Our recently engineered FGF1 partial agonist, carrying triple mutations (FGF1^△HBS) exhibits greatly reduced proliferative potential, while preserving the full metabolic activity of wild-type FGF1. This study tests the preventive and therapeutic effects of FGF1^△HBS on NAFLD in db/db T2D and explores potential mechanisms. The results showed that administration of FGF1^△HBS to 2-month-old db/db mice for 2 months constantly lowered blood glucose levels, improved insulin sensitivity, and lowered liver weight, lipid deposition, and …

Bayesian Analytical Approaches For Metabolomics : A Novel Method For Molecular Structure-Informed Metabolite Interaction Modeling, A Novel Diagnostic Model For Differentiating Myocardial Infarction Type, And Approaches For Compound Identification Given Mass Spectrometry Data., Patrick J. Trainor

Electronic Theses and Dissertations

Metabolomics, the study of small molecules in biological systems, has enjoyed great success in enabling researchers to examine disease-associated metabolic dysregulation and has been utilized for the discovery biomarkers of disease and phenotypic states. In spite of recent technological advances in the analytical platforms utilized in metabolomics and the proliferation of tools for the analysis of metabolomics data, significant challenges in metabolomics data analyses remain. In this dissertation, we present three of these challenges and Bayesian methodological solutions for each. In the first part we develop a new methodology to serve a basis for making higher order inferences in metabolomics, …

An Examination Of Box Office Relationship Quality And Relationship Selling In Division I College Athletics., James F. Weiner

Electronic Theses and Dissertations

College athletics departments have experienced unprecedented growth. However, expenses have risen even faster (Fulks, 2016), and university athletics departments have relied on increased subsidies from host institutions and donations to make ends meet (Fulks, 2016). The root cause behind much of the revenue increases have been credited to large multimedia and broadcast contracts, which guarantee substantial income for decade-long terms (Sherman, 2016). Such agreements leave little room for individual growth, leaving ticket sales as one of the few controllable revenues to which a school could manipulate their own bottom line and increase profitability. Further investigation into box office sales trends …

Deciphering The Role Of Human Arylamine N-Acetyltransferase 1 (Nat1) In Breast Cancer Cell Metabolism Using A Systems Biology Approach., Samantha Marie Carlisle

Electronic Theses and Dissertations

Background: Human arylamine N-acetyltransferase 1 (NAT1) is a phase II xenobiotic metabolizing enzyme found in almost all tissues. NAT1 can additionally hydrolyze acetyl-coenzyme A (acetyl-CoA) in the absence of an arylamine substrate. NAT1 expression varies inter-individually and is elevated in several cancers including estrogen receptor positive (ER+) breast cancers. Additionally, multiple studies have shown the knockdown of NAT1, by both small molecule inhibition and siRNA methods, in breast cancer cells leads to decreased invasive ability and proliferation and decreased anchorage-independent colony formation. However, the exact mechanism by which NAT1 expression affects cancer risk and progression remains unclear. Additionally, consequences …

Unfolded Protein Response Pathways In Skeletal Muscle Homeostasis., Kyle R. Bohnert

Electronic Theses and Dissertations

Skeletal muscle mass, contractile properties, and metabolic function are regulated through the coordinated activation of multiple intracellular signaling pathways and genetic reprogramming. The endoplasmic reticulum (ER) plays a pivotal role in protein folding and calcium homeostasis in many cell types, including skeletal muscle. Disruption of calcium levels or accumulation of misfolded proteins in the ER lumen leads to stress, which results in the activation of a signaling network called the unfolded protein response (UPR). Further, recent studies have suggested that in certain conditions, UPR pathways can be activated independent of ER stress. However, the role of ER stress and the …

Investigating The Impact Of Nrmt1 Cancer Mutants On Catalytic Specificity And The Dna Damage Response., Kaitlyn Marie Shields

Electronic Theses and Dissertations

Protein methylation is an established and critical posttranslational modification controlling multiple cellular events. Alterations in protein methylation have been implicated in many diseases, including cancer. My work focused on the N-terminal trimethylase NRMT1 and the N-terminal monomethylase NRMT2. Previous work proposed that NRMT2 assists NRMT1 by priming its substrates for trimethylation. Importantly, NRMT1 mutations have been found in cancers, and loss of NRMT1 has been shown to promote oncogenic phenotypes in cancer cells. Together, this suggests that altered activities of NRMT1/2 may play a role in cancer progression. Although NRMT1/2 are 50% identical, they differ in key aromatic residues in …

Weight Stigma And Motivation To Exercise : Exploring Associations And Constructs From The Basic Needs Theory., Stephanie R. Mcdonough

Electronic Theses and Dissertations

Social influences, such as weight stigma, perpetuate rates of overweight and obesity, as well as contribute to poor physical and psychological health. It has been postulated that weight stigma negatively affects motivation to exercise, though the literature is mixed and underlying mechanisms of action are not well conceived. The present study aimed to: (1) explore the relationship between frequency of experienced weight stigma and exercise motivation and behavior (2) assess how frequency of experienced weight stigma might differ based on participant characteristics such as body weight and (3) consider unique associations between frequency of personal experiences with weight-based stigma, exercise …

Effects Of Context And Individual Differences On Memory For Prior Remembering., Marcus L. Leppanen

Electronic Theses and Dissertations

Though people often remember experiences from their lives, they are also able to remember whether a memory has previously been retrieved, which is known as memory for prior remembering. Frequent failures of memory for prior remembering can have negative consequences on how people perceive their own cognitive health. The recurrence of traumatic memory retrieval can be interpreted as a consequence of intrusive memory for prior remembering. This dissertation was conducted to improve our understanding of the factors that influence the efficacy of memory for prior remembering. The two factors that were investigated were context change and individual differences. Participants ( …