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An Ethical Model For Mandatory Reporting To Avoid Preventable Adverse Harm In Health Care, Kate A. Molchan
An Ethical Model For Mandatory Reporting To Avoid Preventable Adverse Harm In Health Care, Kate A. Molchan
Electronic Theses and Dissertations
The goal of the dissertation is to undertake an analysis in healthcare ethics that focuses upon organizational ethics to resolve problems related to medical error in the U.S. The ethical argument focuses upon justifying a model of mandatory reporting nationally. While countless others have argued in favor of the implementation of a mandatory reporting system, this dissertation presents its model through the lens of organizational theory; arguing first that healthcare organizations are ethically required to invest in patient safety. This premise frames the foundation for this dissertation's central argument; namely, that U.S. healthcare organizations have an ethical imperative to protect …
Screen Time, Sleep, And Mental Health: An Investigation Of Electronics Use And Sleep Habits, Robert Nicks
Screen Time, Sleep, And Mental Health: An Investigation Of Electronics Use And Sleep Habits, Robert Nicks
Electronic Theses and Dissertations
Internet addiction (IA) is classified as a compulsive-impulsive behavior disorder involving excessive use of the internet, withdrawal, tolerance, and negative repercussions (Block, 2007). Internet usage is becoming more widespread across all industrialized people, and younger people are using the internet more and more as it becomes more ubiquitous (Rideout, Foehr, & Roberts, 2010). The purpose of the current study is to investigate internet usage habits, sleep disturbance, and IA as it appeared in a national United States sample, and a sample seeking clinical psychological help in the Southwestern United States. The results of the current study suggested that IA predicted …
Establishment Of Turfgrass From Seed And Sod In Sand Based Systems Combining Sprinkler And Subsurface Drip Irrigation Systems, Roshaan Ahmed Khan Niazi
Establishment Of Turfgrass From Seed And Sod In Sand Based Systems Combining Sprinkler And Subsurface Drip Irrigation Systems, Roshaan Ahmed Khan Niazi
Electronic Theses and Dissertations
The establishment of turfgrass using subsurface drip irrigation (SDI) in sand based media has limited success. However, it is unknown if starting with overhead (sprinkler) irrigation and transitioning to SDI can enhance turfgrass establishment. Two experiments were conducted at Stephen F. Austin State University (SFASU) to investigate the establishment of “L-93” creeping bentgrass (Agrostis stolonifera) from seed and “TifEagle” ultra dwarf hybrid bermudagrass (Cynodon dactylon x Cynodon transvaalensis) from sod using sand based media. Each experiment consisted of two trials conducted in summer 2017 and spring 2018. Both creeping bentgrass trials and the spring ultra dwarf …
The Effects Of Social Proof Through Social Media On Perceptions Of Responsibility, Taylor Powers
The Effects Of Social Proof Through Social Media On Perceptions Of Responsibility, Taylor Powers
Electronic Theses and Dissertations
Situational crisis communication theory, also referred to as SCCT, is a central and very well-developed theory in the field of crisis communication. The goal of SCCT is to create a response strategy based on stakeholders’ levels of attributions of responsibility. SCCT states there are two main factors stakeholders take into consideration when attributing responsibility to an organization in crisis: crisis type and performance history. While the previously stated factors are very important, the progressive development of social media is not taken into consideration in this theory, specifically the use of social proof through social media channels. According to the principle …
Identifying Inclusive Practices On U.S. University Campuses That Create Engagement For Diverse Populations, Brandon Tatum
Identifying Inclusive Practices On U.S. University Campuses That Create Engagement For Diverse Populations, Brandon Tatum
Electronic Theses and Dissertations
Interactions between diversity and inclusion have been incompletely studied on U.S. college campuses. Previous researchers have also demonstrated an incomplete understanding of these two constructs, resulting in uneven attempts to create inclusion on college campuses. Diversity and inclusion research on college life is needed because inclusion is relatively new and unexplored, student diversity in U.S. higher education is increasing, and practical models and programs for enhancing campus inclusion are lacking. Therefore, the purpose of this study was to identify best practices and student attitudes regarding inclusion and group memberships with Generation Z and Millennial college students in the United States, …
Is There Hope For Teacher Burnout?, Ami Houston
Is There Hope For Teacher Burnout?, Ami Houston
Electronic Theses and Dissertations
The nation’s educational system is faced with an ongoing issue as teachers are choosing to leave the profession in staggering numbers. Teacher attrition affects not only teachers who have already left the field and those currently still in it but also those who would potentially enter the teacher pipeline and students in the care of these teachers. While several factors are at fault for this phenomenon, one of the most pressing contributors to teacher attrition is teacher burnout, as teachers are exposed to exhaustion, cynicism, and decreasing self-efficacy. The purpose of this study was to examine relationships between the dimensions …
Anxiety, A Growing Social Problem: A Systematic Review Of The Literature, Adela Robinson
Anxiety, A Growing Social Problem: A Systematic Review Of The Literature, Adela Robinson
Electronic Theses and Dissertations
Anxiety disorders as a stand-alone diagnosis are not recognized as a treatable mental health issue within the social services mental health realm. There are mixed results regarding if anxiety disorders are linked to suicide ideation and suicide attempts. The aim of this systematic review was to discover if there is a link between anxiety disorders and suicide ideation and suicide attempts within the current literature. All anxiety disorders were looked at, except for selective mutism and separation anxiety disorder due to these both typically only affecting those in very young childhood. The rest of the anxiety disorders affect those from …
The Role Of Cathelicidin In The Regulation Of Gut Microbiota And Inflammasome Activation In Alcoholic Liver Disease., Fengyuan Li
The Role Of Cathelicidin In The Regulation Of Gut Microbiota And Inflammasome Activation In Alcoholic Liver Disease., Fengyuan Li
Electronic Theses and Dissertations
Alcoholic liver disease (ALD) is characterized by gut dysbiosis and hepatic and intestinal inflammation. Gut microbiota is critically maintained by antimicrobial peptides (AMPs) expressed in the epithelial and immune cells. AMPs are also identified as immune-regulators in various diseases. Previous studies demonstrated that deficiency of AMPs REG3 lectins exacerbated alcoholic steatohepatitis. LL-37 is the sole member of human cathelicidin AMP family, named CRAMP in mouse. Despite of the extensive studies in infectious diseases and in gut-microbiota-related inflammatory bowel disease, the role of LL-37/CRAMP in ALD is yet unknown. Our previous studies showed a decreased intestinal CRAMP in a mouse model …
Public Policy And Strategies To Support Institutional And Technological Innovations In The New Water Economy: The Example Of Innovation Technology Clusters In Developing And Diffusing Water Technologies., Craig Francis Barham
Electronic Theses and Dissertations
A long list of water technologies has been central to human development throughout history. From the well in ancient times to desalination in the contemporary period, water technologies are needed to produce, distribute and treat water to support human life, industry, agriculture, and environmental health. As human development puts intense pressure on the planet's limited fresh water supplies, society is turning to increasingly innovative water technologies to close the supply-demand gap. The water economy represents a significant share of total economic output it its own right, while at the same time water directly or indirectly underpins all other economic activity. …
Characterizing The Gut Microbiota During Plasmodium Infection And Antimalarial Treatment., Joshua E. Denny
Characterizing The Gut Microbiota During Plasmodium Infection And Antimalarial Treatment., Joshua E. Denny
Electronic Theses and Dissertations
Plasmodium, the parasitic cause of malaria, is a global pathogen, annually causing 216 million infections and 445,000 deaths. As drug resistance continues develop and no effective vaccine is available, it is critical to understand the factors underlying the severity of this disease. Plasmodium is an extra-gastrointestinal tract infection where the parasite infects red blood cells causing clinical malaria. However, recent publications have pointed to interactions between the gut microbiota and malaria. With this in mind, the role of the gut microbiota in malaria infection was studied. C57BL/6 mice from different vendors displayed differential resistance and susceptibility to severe malaria, …
Physical Education Activity Courses: An Exploration Of How Enrollment Influences Student Retention Rates., Dylan J. Naeger
Physical Education Activity Courses: An Exploration Of How Enrollment Influences Student Retention Rates., Dylan J. Naeger
Electronic Theses and Dissertations
Nationally, student retention rates continue to be a problem, as the National Center for Education Statistics (2018) found the six-year undergraduate graduation rate for students who started college in fall 2010 was around 60%. An area not yet investigated is if any association exists between enrollment in a university physical education activity course (BIP) and academic success. The purpose of this study was to determine how enrollment in a BIP course affected undergraduate student retention rates. This study examined whether enrollment in BIP courses influenced student retention of all first-time, full-time, baccalaureate degree-seeking students enrolled at a public research university …
Modeling And Simulation Methodologies For Spinal Cord Stimulation., Saliya Kumara Kirigeeganage
Modeling And Simulation Methodologies For Spinal Cord Stimulation., Saliya Kumara Kirigeeganage
Electronic Theses and Dissertations
The use of neural prostheses to improve health of paraplegics has been a prime interest of neuroscientists over the last few decades. Scientists have performed experiments with spinal cord stimulation (SCS) to enable voluntary motor function of paralyzed patients. However, the experimentation on the human spinal cord is not a trivial task. Therefore, modeling and simulation techniques play a significant role in understanding the underlying concepts and mechanics of the spinal cord stimulation. In this work, simulation and modeling techniques related to spinal cord stimulation were investigated. The initial work was intended to visualize the electric field distribution patterns in …
Student Perception Of The Effects Of Out Of School Suspension On Academic Motivation., Dawn Boone Roseberry
Student Perception Of The Effects Of Out Of School Suspension On Academic Motivation., Dawn Boone Roseberry
Electronic Theses and Dissertations
Historically, the response to rule violations and misbehavior in schools was to punish students by using methods such as exclusionary discipline. Exclusionary discipline may lead to poor academic outcomes for the student, increased likelihood of dropping out of school, and an introduction to the criminal justice system (Cueller and Markowitz, 2015). Being suspended from school also increases the chances a student will feel disconnected, intensify conflict with adults, and impact a youth’s choice to engage in criminal activities (Skiba et al., 2006). Researchers have concluded that suspension is also a predictor of future suspensions, not a deterrent (Rafaele & Mendez, …
Furthering Understanding Of Forensic Units: A Detailed Examination Of Knoxville Police Department's Crime Scene Unit., Cassandra Christina Rausch
Furthering Understanding Of Forensic Units: A Detailed Examination Of Knoxville Police Department's Crime Scene Unit., Cassandra Christina Rausch
Electronic Theses and Dissertations
Throughout the past three decades, the criminal justice system has decidedly employed new technologies for the purposes of establishing guilt or innocence. Forensic science, with its synthesis of scientific methodology and investigative considerations of law enforcement, ushered in the development of DNA profiling and forever changed the process of crime scene investigation.This shift in focus also led to a shift in the individuals involved in investigation, producing the widespread formation of stand-alone crime scene units. Utilizing both civilian and sworn employees of a law enforcement agency, these units became responsible for the documentation, collection, and preservation of evidence that would …
Is The Sum Greater Than The Parts? A Qualitative Case Study Of Cross-Functional Team Creativity., Tracy J. Richardson
Is The Sum Greater Than The Parts? A Qualitative Case Study Of Cross-Functional Team Creativity., Tracy J. Richardson
Electronic Theses and Dissertations
Creativity is an important capability for organizations to develop solutions for complex challenges. Cross-functional teams are often used within organizations in the hope of leveraging diverse perspectives to develop creative ideas. However, the process by which cross-functional teams generate new ideas is often elusive in practice and poorly understood in research. A case-study design was used to explore the complex nature of the creative process within a services industry organization, which is an understudied context for creativity. The study focused on the knowledge sharing and knowledge integration processes for cross-functional teams as well as overall team effectiveness. The results of …
Effects Of Hydrogen Sulfide In Hyperhomocysteinemia-Mediated Skeletal Muscle Myopathy., Avisek Majumder
Effects Of Hydrogen Sulfide In Hyperhomocysteinemia-Mediated Skeletal Muscle Myopathy., Avisek Majumder
Electronic Theses and Dissertations
Although hyperhomocysteinemia (HHcy) occurs due to a deficiency in cystathionine-β-synthase (CBS), causing skeletal muscle myopathy, it is still unclear whether this effect is mediated through oxidative, endoplasmic reticulum (ER) stress, both or something else. Cystathionine γ-lyase (CSE) and CBS are the main H2S producing enzymes, which produce Hydrogen sulfide (H2S) from Hcy in the transsulfuration reaction. H2S is an anti-oxidant compound and patients with a CBS deficiency cannot produce enough H2S, thus rendering them vulnerable to excess Hcy-mediated damage. Both in-vitro (C2C12 cells) and in-vivo (CBS+/- mice) models were used to …
Lead And Crime: An Ecological Study Between Lead Contaminated Topsoil And Violent Crime., Brian Guinn
Lead And Crime: An Ecological Study Between Lead Contaminated Topsoil And Violent Crime., Brian Guinn
Electronic Theses and Dissertations
Lead is a known neurotoxicant. Human exposure to lead comes primarily through environmental exposures, including remnant lead paint, lead contaminated topsoil and lead contaminated water. Prenatal and early life lead exposure has been associated with numerous neurocognitive and neuropsychiatric disorders. This dissertation presents findings from an ecological study which evaluated the geospatial association between topsoil lead content and the incidence of FBI designated violent crime in Jefferson County, Kentucky. A total of 412 topsoil samples were collected along roadways (n=300) and from Louisville Metro Parks (n=112). Jefferson County crime data was obtained from the Louisville Metro Police Department – Crime …
Impacts Of Ammonia And Temperature On Freshwater Snail Behavior And Physiology., Megan Christine Dewhatley
Impacts Of Ammonia And Temperature On Freshwater Snail Behavior And Physiology., Megan Christine Dewhatley
Electronic Theses and Dissertations
Gastropods are one of the most imperiled groups of animals in North America, yet there are major gaps in the literature pertaining to pollutants and climate change, and especially sublethal impacts. This dissertation assesses the effects of climate warming and unionized ammonia (NH3), one of the most abundant water pollutants, on the behavior and physiology of two caenogastropod snails: fine-ridged elimia (Elimia semicarinata) and Shawnee rocksnails (Lithasia obovata) (Gastropoda: Neotaenioglossa: Pleuroceridae). Righting behavior, or the movement used by snails to turn themselves right-side-up, was used as the main endpoint; delays in this behavior compromise …
Role Of Trkb-Signaling In Taste Development And Function., Jennifer Rios-Pilier
Role Of Trkb-Signaling In Taste Development And Function., Jennifer Rios-Pilier
Electronic Theses and Dissertations
In the geniculate ganglion, taste neurons likely differentiate into subtypes during development, but very little is known about how these neurons are defined molecularly or how they differentiate. Embryonically, geniculate neuron development is regulated by the growth factor, brain derived neurotrophic factor (BDNF). Postnatally, BDNF becomes restricted to subpopulations of taste receptor cells with specific functions, primarily sour responding. I hypothesized that during development, the receptor for BDNF, tropomyosin kinase B receptor (TrkB), also becomes restricted to a neuronal subset. I used transgenic mouse models to label and quantify both geniculate sensory neurons (Phox2b+), and those expressing TrkB (GFP) across …
Association Between Cigarette Smoking And Ovarian Reserve Among Women Seeking Fertility Treatment With Effect Modification By Race And Nat2 Genotype., Islamiat A. Oladipupo
Association Between Cigarette Smoking And Ovarian Reserve Among Women Seeking Fertility Treatment With Effect Modification By Race And Nat2 Genotype., Islamiat A. Oladipupo
Electronic Theses and Dissertations
Cigarette smoking in women has been associated with adverse reproductive outcomes such as reduced ovarian reserve, poorer in vitro fertilization (IVF) outcomes and increased adverse pregnancy outcomes. This study examined the association of smoking with ovarian reserve in a cross-sectional study of women seeking fertility treatment, and potential effect modification by race and NAT2 acetylator phenotype. Data from 265 women from the Louisville Tobacco Smoke, Genetic Susceptibility, and Infertility (LOUSSI) Study were analyzed. A total of 265 women were recruited through a single infertility clinic between September 2016 and June 2018. Information on current smoking status was assessed using a …
Assessing The Affects Of Treatment Services, Financial Assistance, Race/Ethnicity, And Income On The Criminal Justice Outcomes Of Women On Probation., Jordan Wilfong
Electronic Theses and Dissertations
The aim of this study is to examine the affect that treatment services have on the criminal justice outcomes of women on probation. The research to date on the treatment services provided to the criminal justice population has tended to focus on prisoners rather than probationers, with even fewer studies that include samples of women on probation. This study will investigate the impact on criminal justice outcomes of services intended to treat issues identified to increase recidivism among female probationers, such as substance use disorders, illicit drug use, mental health issues, and poverty. An additional assessment is conducted to determine …
Assessing The Role Of Arsenite In Disrupting The Egfr Signaling Axis., Christine Kim
Assessing The Role Of Arsenite In Disrupting The Egfr Signaling Axis., Christine Kim
Electronic Theses and Dissertations
The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase localized on the cell surface. Overexpression of EGFR has been used as biomarkers for many different types of cancers, including lung cancer. There is a strong association between arsenic and lung cancer development, although the mechanism is unclear. We hypothesize that chronic exposure of “a physiologically relevant” level of arsenite disrupts the EGFR endocytic trafficking. The goal of this project is to identify molecular mechanisms and roles of chronic arsenite-induced EGFR overexpression in lung cancer development. A non-malignant human bronchial epithelial cell line, Beas-2B cells were exposed to 100 …
The Migration And Developmental Remodeling Of Intrinsic Interneurons In Visual Thalamus And The Role Of Retinal Signaling., Naomi E. Charalambakis
The Migration And Developmental Remodeling Of Intrinsic Interneurons In Visual Thalamus And The Role Of Retinal Signaling., Naomi E. Charalambakis
Electronic Theses and Dissertations
The dorsal lateral geniculate nucleus (dLGN) of the mouse is a model system to study the development of thalamic circuitry. While most studies focus on relay neurons of dLGN, little is known about the factors regulating the development of the other principal cell type, intrinsic interneurons. To date, the targeting and migratory path of dLGN interneurons as well as their morphological development remains unclear. Here we examined whether the migration, structure, and function of interneurons relies on retinal signaling. We took a loss-of-function approach and crossed GAD67-GFP mice, which express green fluorescent protein (GFP) in dLGN interneurons, with math5 nulls …
Is Macrolide And Beta-Lactam Combination Therapy Associated With Early Clinical Stability Or 30 Day Mortality In Hospitalized Patients With Pneumonia? An Assessment Of Confounding By Indication., Evangeline Pierce
Electronic Theses and Dissertations
Pneumonia and influenza are one of the leading causes of infectious disease-related deaths worldwide. Current guidelines for the treatment of hospitalized patients with community acquired pneumonia (CAP) include empiric antimicrobial therapy with a macrolide and a beta-lactam. There is little consensus among studies as to which antimicrobial regimen is best. The confusing results seen may very well be due to lack of assessment of confounding by indication (CBI). This analysis was a secondary analysis from Hospitalized Adults with Pneumococcal Pneumonia: Incidence Study (HAPPI). The study participants were those in HAPPI who had received either macrolide and beta-lactam combination therapy or …
Investigating The Unique Reactivity Of Novel Hx (X=Cl, Br) Reagents With Alkenes And Alkynes., Rene E. Ebule
Investigating The Unique Reactivity Of Novel Hx (X=Cl, Br) Reagents With Alkenes And Alkynes., Rene E. Ebule
Electronic Theses and Dissertations
The addition of hydrogen halides to carbon-carbon unsaturated systems is a classic synthetic transformation that gives rise to a variety of halogenated products as well as building blocks.1 The different routes to achieve hydrohalogenation make use of the hydrogen halides either in the gaseous form2 or in solution3, or their surrogates4. Only second to dihalogens, hydrogen halides are the most atom efficient source of halogenation. However, hydrogen halides are reactive gases at ambient temperature, posing a major challenge in their application. Handling gaseous hydrogen halide reagents requires expert knowledge and specialized equipment. We have …
Influence Of Bilberry-Derived Anthocyanidins On Key Regulators Of Colorectal Cancer Development., Ashley M. Mudd
Influence Of Bilberry-Derived Anthocyanidins On Key Regulators Of Colorectal Cancer Development., Ashley M. Mudd
Electronic Theses and Dissertations
Colorectal cancer (CRC) is the third leading cause of cancer-related deaths within the United States. A variety of factors including exposure to environmental carcinogens, such as benzo[a]pyrene (B[a]P), dysbiosis of the gut microbiome and hereditary influences, including APC mutations, have been shown to lead to an increased risk of developing colorectal cancer. Given the recent alarming rise in cases of colorectal cancer diagnosed in individuals under the age of 40, further insight into developing novel and effective prevention and treatment strategies are warranted. The family of plant pigments known as the anthocyanins has been identified with …
Repetitive Negative Thinking Styles And First-Semester Academic Performance: Psychological Risk And Resilience Among Low-Income College Students., Darlene M. Davis
Repetitive Negative Thinking Styles And First-Semester Academic Performance: Psychological Risk And Resilience Among Low-Income College Students., Darlene M. Davis
Electronic Theses and Dissertations
College students face significant mental health and academic challenges their first academic year. The college transition period can be stressful. In addition, students are increasingly endorsing anxious and depressive symptoms. Depressive and anxious symptoms are linked to repetitive negative thinking styles that present in college students, which contributes to academic interference. The first year of college can be challenging for students who are unable to adjust and adapt. Students who struggle and feel overwhelmed by life stressors experience psychological disruption that interferes with academic performance. Growing up in poverty has been associated with lower grade point averages and poorer graduation …
How Do Entrepreneurs React To Investor Rejection, Try Harder Or Move On?, Yuhan Hua
How Do Entrepreneurs React To Investor Rejection, Try Harder Or Move On?, Yuhan Hua
Electronic Theses and Dissertations
Rejected by the investor is a common challenge that entrepreneurs face in the startup process. This study investigates how entrepreneurs respond to investor rejection. The results indicate the rejection can motivate entrepreneurs to learn from the rejection and improve venture image. Meanwhile, investor rejection can also increase entrepreneurs’ tendency of withdrawal from the investor and exit intention. Rejected by investor also increase entrepreneurs’ doubts about the investors’ competency. This study finds both the alternative funding source and the fairness of the rejection can impact entrepreneurs’ rejection responses. Also, the individual difference influences how entrepreneurs deal with investors’ rejection. The empirical …
Virulence Regulation In Pseudomonas Aeruginosa Via The Alginate Regulators, Algu And Algr, The Posttranscriptional Regulator, Rsma, And The Two-Component System, Algz/R, Sean Stacey
Electronic Theses and Dissertations
Pseudomonas aeruginosa is a Gram-negative bacillus able to colonize a wide variety of environments. In the human host, P. aeruginosa can establish an acute infection or persist and create a chronic infection. P. aeruginosa is able to establish a niche and persist in human hosts by using a wide array of virulence factors used for: movement, killing host cells, and evading immune cells and antibiotics. Understanding virulence factors and their regulation has proved to be an important means of combating the morbidity and mortality of P. aeruginosa as well as the ever-increasing threat of drug resistance. By targeting virulence factors …
Innate Immunity, The Hepatic Extracellular Matrix, And Liver Injury: Mathematical Modeling Of Metastatic Potential And Tumor Development In Alcoholic Liver Disease., Shanice V. Hudson
Innate Immunity, The Hepatic Extracellular Matrix, And Liver Injury: Mathematical Modeling Of Metastatic Potential And Tumor Development In Alcoholic Liver Disease., Shanice V. Hudson
Electronic Theses and Dissertations
The overarching goals of the current work are to fill key gaps in the current understanding of alcohol consumption and the risk of metastasis to the liver. Considering the evidence this research group has compiled confirming that the hepatic matrisome responds dynamically to injury, an altered extracellular matrix (ECM) profile appears to be a key feature of pre-fibrotic inflammatory injury in the liver. This group has demonstrated that the hepatic ECM responds dynamically to alcohol exposure, in particular, sensitizing the liver to LPS-induced inflammatory damage. Although the study of alcohol in its role as a contributing factor to oncogenesis and …