Digital Commons Network^™

Using Active Learning Techniques To Improve Oral Health Literacy Among Children In Vulnerable Populations., Sarah Maria Downes

Electronic Theses and Dissertations

This thesis examines the effectiveness of an active learning approach in improving oral health literacy and attitude about science among at-risk students in the age range of third to sixth grades. This is done by designing and implementing a novel Oral Health Outreach module and video. Active learning components include engaging PowerPoint, oral hygiene discussion and demonstration, and finally a biofilm simulation, which utilizes glow-in-the-dark paint, dentoform models, and black lights that allow students to visualize the importance of plaque removal. Student comprehension of oral health concepts increased by an average of 52.4% on post-tests (n=61, p

Soil Nutrient And Contaminant Assessment In Community Gardens, Louisville, Kentucky., Jessica Lynne Eggleston

Electronic Theses and Dissertations

Urban population impact on environmental warming has inspired interest in vegetative coverage to mitigate human influence. Community gardens are proposed to increase green space and access to fresh food, improve health, and quality of life. The potential for soil contamination in post-industrial cities is high presenting a health risk for gardeners. Three Louisville, Kentucky community gardens were chosen for analysis of soil texture, pH, concentration of trace nutrients and metals using Mehlich 1 Extraction. In two community gardens, relative absence of heavy metals suggest they are currently safe for gardening. One garden had a concentration of copper and zinc over …

Changing Agricultural Landscapes: An Investigation Of Dragon Fruit Production In Southern Vietnam., Laura Krauser

Electronic Theses and Dissertations

Agricultural transition represents an essential component of land-use and land-cover change in developing countries across the world, as economic and social factors pressure agriculturalists out of traditional subsistence farming into food commodity production. Modernization has altered modes of income, land ownership, and livelihood in Southeast Asia drastically in recent years. The Bình Thuận Province of southern Vietnam experienced a particularly radical transformation with the introduction of dragon fruit cultivation, which has been profoundly encouraged by outside markets in China, Australia, and Japan. This research combines remote sensing and qualitative research to examine and characterize a changing agricultural landscape in rural …

Assessing Predictors Of Harmful Algal Blooms In The Western Lake Erie Basin., Katherine M. Weigle

Electronic Theses and Dissertations

Harmful algal blooms (HABs) have been a recurring issue in the Western Lake Erie Basin for more than a decade, despite policies implemented to improve the water quality of the Great Lakes. HABs describe algae that can be harmful to both ecosystem function and human health. The Western Lake Erie Basin, in particular, experiences Microcystis aeruginosa blooms in the summer months due to a multitude of factors leading to increased phosphorus and nitrogen loads in the contributing watersheds. In this study, lake water surface temperature, land cover, river discharge, and precipitation were examined as potential triggers for the occurrence and …

An Analysis Of The Role Of Reality Television In The Representation Of Immigrants On Tlc's Show, 90 Day Fiancé., Morohunfolu Jimade Seton

Electronic Theses and Dissertations

A larger number of people reside outside their country of birth today than in any other time in history, and these levels are expected to continue to rise in the future (International Organization for Migration, 2011). The United States is currently the most popular immigrant destination in the world, with more immigrants than any other country. Immigrants statistics indicate that the immigrant population in the United States reached a record of 44.4 million in 2017 (Pew Research Centre, 2019). Correspondingly, the percentage of immigrants who were admitted into the U.S. as spouses of citizens has increased over of the last …

Factors Of Dysphagia In The Overdose Population Post Extubation., Renee Brown

Electronic Theses and Dissertations

Post-extubation dysphagia (PED) has been studied in depth in a variety of populations including elective heart surgeries, trauma, critical illness, traumatic brain injury, and those requiring mechanical ventilation, but has not been researched in the overdose population (OD). This study aims to research factors of PED in the OD population. A retrospective study was conducted and found 24 participants who fit the inclusionary requirements. Correlation statistics were run between age and duration of intubation, age or duration of intubation and gender, and between intubation duration, age, and scores on Penetration-Aspiration Scale (P/A) (thin by cup and thin by straw). The …

Novel Inference Methods For Generalized Linear Models Using Shrinkage Priors And Data Augmentation., Arinjita Bhattacharyya

Electronic Theses and Dissertations

Generalized linear models have broad applications in biostatistics and sociology. In a regression setup, the main target is to find a relevant set of predictors out of a large collection of covariates. Sparsity is the assumption that only a few of these covariates in a regression setup have a meaningful correlation with an outcome variate of interest. Sparsity is incorporated by regularizing the irrelevant slopes towards zero without changing the relevant predictors and keeping the resulting inferences intact. Frequentist variable selection and sparsity are addressed by popular techniques like Lasso, Elastic Net. Bayesian penalized regression can tackle the curse of …

The Role Of Inter-Enlargement Propriospinal Neurons In Locomotion Following Spinal Cord Injury., Courtney Therese Shepard

Electronic Theses and Dissertations

The focus of this dissertation is to explore the functional role of two anatomically-defined pathways in the adult rat spinal cord before and after spinal cord injury (SCI). To do this, a Tet^On dual virus system was used to selectively and reversibly silence neurons with cell bodies at spinal segment L2 and projections to spinal segment C6 (long ascending propriospinal neurons, LAPNs) and neurons that originate in the C6 spinal segment and terminate at L2 spinal segment (long descending propriospinal neurons, LDPNs). This dissertation is divided into five chapters. Chapter One provides background information regarding spinal cord injury, locomotion, …

Good Grief: An Analysis Of The Character Development Of Tonya In August Wilson’S King Hedley Ii Through The Lens Of “The Five Stages Of Grief”., Kala Ross

Electronic Theses and Dissertations

An actor who is portraying a grieving character can also grieve simultaneously about the character’s given circumstances, which affects the character development and mental health of the actor. This thesis assesses how the character Tonya, in August Wilson’s King Hedley II, engages with grief as an African American woman and offers a process for the actor to engage and disengage with loss. “Good Grief” will unpack Constantin Stanislavski’s system of acting, focusing on the Magic “If” and the given circumstances, while also introducing the “Five Stages of Grief” coined by Elisabeth Kubler-Ross. Through the scholarship of theatre practitioners and psychologists …

The Effects Of Self-Regulated Strategy Development Instruction On Argument Writing Skills Of Adolescents With Mild Disabilities., Stacy Crawford Bewley

Electronic Theses and Dissertations

Recent data from the National Center for Education Statistics (2012) indicates that a large majority of students with disabilities continue to perform at basic proficiency or below in the area of writing, which has serious implications for post-secondary academic endeavors and successful transition into the workforce (US Department of Labor, 2014; Bureau of Labor Statistics, 2017). Therefore, it is imperative to identify and implement effective writing interventions for this population of students. Self-Regulated Strategy Development (SRSD) has been widely researched in elementary and middle school settings, but much less research has been conducted with high school students. The purpose of …

Converting Threats Into Opportunities Predicting Medical Error Reporting Behavior., Whitney Thomas Rogers

Electronic Theses and Dissertations

Medical errors are a public health epidemic and a major threat to patient safety. Estimates suggest they may be responsible for 210,000 - 440,000 preventable deaths per year. This would make medical errors the third leading cause of death in the United States. The societal burden of medical errors is steep, with the economic impact near $1 trillion. The purpose of this study was to use a theory-driven approach to better understand the reporting behavior of healthcare professional. Increased error reporting leads to heightened awareness of the precursors or conditions generating errors, which can then be corrected. In its most …

"It's Personal": A Case Study Analysis Of The Strategic Management Of Resources In A Historically Black University Athletic Department., Brigitte M. Burpo

Electronic Theses and Dissertations

This dissertation is a qualitative case study examination of the strategic management of critical resources in an HBCU athletic program. It begins with a historical overview of HBCUs and HBCU athletic departments focusing on the systemic and societal influences that contributed to the current state of HBCU athletic programs. This dissertation later discusses the influence of a lack of financial resources on HBCU athletic departments further depletes the ability to operate with a competitive advantage. Chapter One focuses on the historic background of HBCUs and their formation as well as the societal influences that depleted critical resources. Chapter Two covers …

A King's Royal Scars., Xavier Mikal Harris

Electronic Theses and Dissertations

This monograph is divided into five chapters covering my exploration of black male identity in America and the scars that come with it. Through a character study of the black male protagonist I portrayed in August Wilson’s King Hedley II, I will discuss the racial stigmas and circumstances that are tied to black male identity. Chapter one will consist of analyzing the prison system in America and how its unfair system targets black men. Chapter two will discuss the plight of poverty that largely affects black communities. Chapters three and four will discuss King Hedley’s dual identities created by …

Optimization And Simulation Models To Improve Access To Organ Transplantation In The United States., Fatemeh Karami

Electronic Theses and Dissertations

Organ allocation in the U.S. is administrated by the United Network of Organ Sharing (UNOS). UNOS’s mission is to ensure fair and equitable allocation of organs as stated in the Code of Federal Regulations, which reads "neither place of residence nor place of listing shall be a major determinant of access to transplant". Despite the regulations, there has been endless controversy surrounding the disparity in access to organ transplants. In this context, the primary research goal in this dissertation was to reduce geographic disparity in access to transplants in the U.S., with a focus on heart and kidney transplants. To …

A Novel Approach To Hiv Prevention: Understanding Multi-Level Influences On Hiv Pre-Exposure Prophylaxis (Prep) Uptake And Outreach Among African Americans., Suur Debrah Ayangeakaa

Electronic Theses and Dissertations

This dissertation examined and provided basis for addressing factors related to HIV pre-exposure prophylaxis (PrEP) engagement, outreach, and uptake among high-risk African American youth groups in Louisville, KY. This qualitative dissertation study was designed through the lens of an interpretive framework of social constructivism which holds that multiple realities and interpretations exist and are socially constructed through the lived experiences of individuals and their interactions with others. Thus, lived experiences of various African American youth groups in Louisville as well as key informants of AIDS service organizations (ASOs) across the U.S. (including Louisville) were explored to develop a deeper understanding …

Tobacco Product-Derived Aldehydes: Effects On Circulating Angiogenic Cells & Implications For Cardiovascular Disease., Jordan B. Lynch

Electronic Theses and Dissertations

Cardiovascular disease (CVD) is the leading cause of death worldwide. Tobacco smoke is the most significant modifiable risk factor in CVD development and contains numerous toxic compounds, including aldehydes, which have been linked to CVD. Formaldehyde, acetaldehyde, acrolein, and crotonaldehyde have been identified as significant contributors to cigarette-induced health effects, but the mechanism of these effects is not well understood. These aldehydes are also found in aerosols produced by e-cigarettes (e-cigs). The goal of this dissertation was to explore the systemic, hematological, and endothelium-related effects of exposure to tobacco products and constituent aldehydes and to identify potential mechanisms of injury. …

Development Of Rationally Designed Live Attenuated Vaccines For Lassa Fever And Venezuelan Equine Encephalitis., Dylan Macgregor Johnson

Electronic Theses and Dissertations

Lassa Virus (LASV) and Venezuelan Equine Encephalitis Virus (VEEV) are two single stranded RNA viruses belonging to the Arenavirus and Alphavirus families, respectively. Both are emerging pathogens without approved vaccines or treatments. VEEV is an important biothreat pathogen because it has been weaponized and is extremely infectious as an aerosol. VEEV causes biphasic febrile illness that can progress to a viral encephalitis with low mortality, but high morbidity. LASV causes a viral hemorrhagic fever, Lassa Fever (LF), which is endemic in West Africa, and responsible for between 100-500k annual infections with a 1-2% overall mortality rate. ML29 and VEEV TC-83 …

Role Of Plant Volatile Organic Compounds (Vocs) In Seed Priming And Plant-Herbivore Interactions., Abhinav Kumar Maurya

Electronic Theses and Dissertations

This dissertation explores and expands the existing knowledge on the role of plant volatiles in facilitating seed priming and providing direct defense against herbivore. Although the roles of plant volatiles in priming a plant’s defenses and providing direct defense against pests is well known, information regarding their effects on seed and the fitness of future plants and direct toxicity to herbivores is understudied. This dissertation does a thorough examination of these two understudied aspects of plant volatiles and provides novel insight into the role of plant volatiles in seed priming and direct defense (Chapter I). Seeds in the soil can …

Mechanistic Insight Of The Role Of Nherf1 In Cisplatin-Induced Acute Kidney Injury., Adrienne M. Bushau-Sprinkle

Electronic Theses and Dissertations

Background. Acute kidney injury (AKI) develops in 30% of patients who receive cisplatin, a widely used chemotherapeutic agent. We previously showed that NHERF1 loss resulted in increased susceptibility to cisplatin nephrotoxicity. The overarching goal of this dissertation was to elucidate mechanisms of susceptibility to cisplatin-induced AKI, specifically the effects of NHERF1 loss on tubule cell metabolism, tubule cell mitochondrial function, and alterations in oxidative state and/or renal handling of cisplatin. Methods. 2-4 month male wild type (WT) and NHERF1 knock out (KO) mice were treated with either vehicle control or cisplatin (20 mg/kg dose IP) for 4, 24, and 72 …

Examining Corporate Blameworthiness In Relation To Federal Organizational Sentencing For Probation And Corporate Monitors., Emily M. Homer

Electronic Theses and Dissertations

Organizations that have benefitted from the commission of federal crimes committed by their employees may be sentenced to federal criminal penalties. Two of these potential penalties include probation and the requirement to implement a corporate monitor. The federal guidelines provide suggestions for sentencing probation that echo the theoretical focal concern of blameworthiness. This research used eight years of United States Sentencing Commission data covering 2011 to 2018 (n= 1,224) to examine if organizations were being sentenced to probation and monitoring consistent with the federal guidelines and focal concern of blameworthiness. The study examined nine potential measures of blameworthiness …

Hirschman's Voice, Exit, And Loyalty Framework In The Context Of Charter Schools And Secession: A Discourse Analysis Of Indiana Newspaper Editorial Items, 1990 To 2014., Glyptusann Grider Jones

Electronic Theses and Dissertations

In this study, I apply secession to Hirschman’s (1970) classic framework to develop a notion of charter school secession. I build beyond his constructs, which I define as Voice₁, Exit₁, and Loyalty_District in the case of dissatisfaction with traditional school governance, to explore whether there is a rhetorically discernible “battle” in Indiana’s charter school development such that actors: (1) have a crisis of legitimacy (claim) against the local school or district (Voice₂); (2) seek to leverage charter school formation as the mechanism to withdraw and establish independence (Exit₂); and (3) defend …

The Long Journey Down Market Street: An Oral History Based Biography Of Mary Craik., Denise Vulhop Watkins

Electronic Theses and Dissertations

This interdisciplinary dissertation examines the life of Mary B. Craik, a Louisvillian who was a professor, feminist activist, philanthropist and artist. The project’s main focus is on Craik’s feminist awakening and activism, and their alignment with second wave feminism. The primary method of data collection was oral history and consisted of interviews with Craik and some of her friends, acquaintances, and colleagues. Additional sources included a scrapbook that documented her major life events, the trial transcript from a gender discrimination lawsuit she launched, and art quilts she made in her later years after she retired. This project examines these resources …

Dual Role Of Antimicrobial Peptide Cathelicidin In Alcohol-Associated Liver Disease., Fengyuan Li

Electronic Theses and Dissertations

Patients with alcohol-associated liver disease (ALD) have high morbidity and mortality in its severe forms. One of the major features in different forms of ALD is the altered gut microbiota. Antimicrobial peptides (AMPs) play a crucial role in maintaining gut microbiota homeostasis. LL-37 (known as CRAMP in mouse) is the sole member of the human cathelicidin family and has piqued great research interest for its dual role in modulating microbiota and the immune response in metabolic diseases. Inflammasome activation is an important component of the liver pathophysiology in ALD and requires two signals for its full activation to induce the …

Identifying Protective Factors Against Overweight And Obesity Within The Social Environment Of Women With Low Incomes., Monica M. Adams

Electronic Theses and Dissertations

Over two-thirds of the United States population have overweight or obese (OW/OB) weight statuses due in large part to an obesogenic environment that encourages unhealthful weight related behaviors. The obesogenic environment appears to place a larger burden on women with low incomes as they experience OW/OB disproportionately compared to other groups. Studies seeking to understand the impact of the obesogenic environment on this population have been deficit focused, largely examining environmental risk factors for OW/OB and ignoring protective factors against it. Most women with low incomes do not have an obese weight status and some women who have OW/OB statuses …

Hotel De Vagabundos: Reviewing African American Theatre Journey., Manuel Francisco Viveros

Electronic Theses and Dissertations

This analysis examines how Hotel de Vagabundos, a play written by a black playwright from Colombia, fits into the core of definitions of Black Theatre in the United States. I will examine six documents I consider relevant to shape the idea of Black Theatre in the US from 1900 through 2005. The author's experience in New York during the 1940s inspires Hotel de Vagabundos. The author navigates the globalized ethos idea unleashing clashes about identity to criticize aspects of American culture about immigrants, poor people, and internalized racism within African American and Black diasporic communities. The play “like a …

The Emerging Oral Pathogen, Filifactor Alocis, Disrupts Neutrophil Functions To Enhance Survival And Dysregulate Inflammation., Irina Miralda Molina

Electronic Theses and Dissertations

Periodontitis is an irreversible, chronic inflammatory disease where pathogenic microbial communities accumulate in the gingival crevice. Advances in culture-independent techniques have facilitated the identification of new bacterial species in periodontal lesions, such as the Gram-positive anaerobe, Filifactor alocis. Neutrophils are a major component of the innate host response, and the outcome of their interaction with F. alocis may be a determinant of oral health status. While neutrophil functions typically protect the host against periodontal disease, oral pathogens have adapted to evade or disarm neutrophil microbicidal functions while promoting mechanisms that drive inflammation, which also provides a source of nutrients …

Tobacco Smoke Exposures And Fertility-Related Outcomes Among Females Seeking Fertility Care, And The Interaction With N-Acetyltransferase 2 (Nat2).., T'Shura S. A. Ali

Electronic Theses and Dissertations

Cigarette smoke contains thousands of harmful substances and is one of the leading preventable causes of mortality and morbidity in the United States. Past studies examining tobacco smoke exposures on fecundability and pregnancy outcomes are inconsistent. NAT2 is an important enzyme in the metabolism of xenobiotic substances found within tobacco smoke. This preconception cohort study examines associations between active smoking and secondhand smoke exposure (SHSe) on fecundability and spontaneous abortion (SA), and explores a possible interaction with NAT2 acetylator status. A total of 223 women seeking fertility care were followed for up to 2.3 years. Preconception tobacco smoke exposures were …

Risks Of Indirect Trauma Among Direct Support Professionals Who Work With Adults With Intellectual/ Developmental Disabilities: Impact On Organizational, Staff And Client Outcomes., Daniel A. Boamah

Electronic Theses and Dissertations

Direct support professionals (DSPs) provide a wide range of support services to persons with ID/DD to ensure their safety and welfare, development of independent living skills and integrate into their community. Existing literature has shown that as frontline workers, DSPs face various occupational hazards such as burnout, yet very little is known about prevalence of secondary trauma stress (STS) among DSPs.

The present study examines the prevalence of STS and the predictive factors of STS and burnout among DSPs who work with adults with ID/DD. In addition, the study looked at the relationships between burnout and STS on organization-related outcomes, …

Aboveground-Belowground Interactions: Roles Of Soil Biotic And Abiotic Factors On Switchgrass's (Panicum Virgatum) Growth, Defense Against Herbivory And Cell Wall Chemistry., Binod Basyal

Electronic Theses and Dissertations

Plants constantly interact with their biotic and abiotic soil environments. Most terrestrial plants form beneficial associations with soil microbes such as arbuscular mycorrhizal (AM) fungi, which are widely known for their ability to transfer soil phosphorus and nitrogen to the host plants. They help plants tolerate drought stress and improve plant defense against herbivores such as plant-parasitic nematodes (PPNs). This dissertation investigates the role of AM fungi on switchgrass’s (Panicum virgatum) growth, cell wall chemistry, and defense against PPNs using a combination of growth chamber and field studies. Switchgrass is a native warm-season species which is gaining traction as candidate …

Quality Of Life Of Adults Who Have Attempted Suicide, Karen Hoefer

Electronic Theses and Dissertations

This study focuses on the quality of life of suicide attempt survivors and the trajectories of their lives after their last attempt in the past two to ten years. Employing both a quantitative and qualitative approach but focusing largely on the qualitative data, I collected demographic data, gathered responses on an abbreviated Reasons for Living Inventory, and conducted open-ended phone interviews with 26 participants. The primary life course finding is that participants’ suicide attempts are often built on years of dealing with mental illness. The analysis also dispels many stereotypes associated with people who have attempted suicide. I explore patterns …