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Development Of Site - Specific Drug Delivery Systems Using Hot Melt Extrusion And Fused Deposition Modeling 3d Printing, Nagireddy Reddy Dumpa
Development Of Site - Specific Drug Delivery Systems Using Hot Melt Extrusion And Fused Deposition Modeling 3d Printing, Nagireddy Reddy Dumpa
Electronic Theses and Dissertations
Due to preferential site of drug absorption and the need for increased concentration of medication at the required tissues, dosage forms should be designed or formulated in such a way that medication is released at a specific site or after a specific time in the gastrointestinal tract (GIT). Knowledge of transit times of dosage forms in each part of GIT, by use of particular polymers or employing specific delivery systems such as floating systems, delivery of medication to specific sites in the GIT can be achieved. HME coupled FDM 3D printing has the capability to create customized dosage forms for …
Polyester-Pamam “Janus-Type” Linear-Dendritic Blockopolymers (Ldbcs) As Next Generation Biomaterials, Indika Chandrasiri
Polyester-Pamam “Janus-Type” Linear-Dendritic Blockopolymers (Ldbcs) As Next Generation Biomaterials, Indika Chandrasiri
Electronic Theses and Dissertations
Nanomedicine is defined as the application of knowledge and tools of nanotechnology for disease treatment, diagnosis, monitoring, delivery, and sensing. Rapid advances in polymer chemistry and nanotechnology have led to an extensive development of polymeric-based therapeutic systems for nanomedical applications. Compared to traditional molecular-based therapies, polymers facilitate a higher level of versatility and functionality, such as simultaneous imaging and delivery. In particular, amphiphilic diblock copolymers and their self-assemblies have shown apparent success in nanomedicine owing to their ability to provide narrow molar mass distributions and highly ordered nanoscale multimolecular aggregates, including micelles and vesicles. However, engineering these polymeric materials to …
Nmr-Based Characterization Of A Glucan Isolated From Ganoderma Lucidum, Alysia Gonzales
Nmr-Based Characterization Of A Glucan Isolated From Ganoderma Lucidum, Alysia Gonzales
Electronic Theses and Dissertations
Ganoderma lucidum is a polypore fungus commonly known as Lingzhi, Youngji or Reishi mushroom in East Asia. It is frequently marketed as an herbal supplement and often utilized as traditional Chinese medicine. Our research comprises the structural investigation of the principal polysaccharide from this fungus. After proper purification, the fungal glucan was subjected to multiple experiments of NMR spectroscopy, including 1D 1H and 13C, 2D; 1H-1H COSY, 1H-1H TOCSY, 1H-1H NOESY, 1H-13C HSQC, 1H-1H Phase Sensitive-TOCSY, and 1H-13C TOCSY-HSQC NMR spectra. Data has confirmed that this fungal polysaccharide contains residues of glucose (91.31%) as major, galactose (4.99%), and mannose (3.69%) …
Teachers Perceptions Of Using Young Adult Literature As A Catalyst To Discuss Social Justice In Mississippi Classrooms, Shimikqua Ellis
Teachers Perceptions Of Using Young Adult Literature As A Catalyst To Discuss Social Justice In Mississippi Classrooms, Shimikqua Ellis
Electronic Theses and Dissertations
ABSTRACT Educational inequality and racial injustice are serious challenges that educators continue to face. More educators are seeking social justice teaching practices and implementing culturally responsive pedagogies to address systemic inequities in schools. Literary scholars suggest that books should serve as mirrors and windows for readers. Diverse young adult literature is a powerful medium through which social injustices, racial inequities, and social problems can be addressed in the classroom. This study is designed to help teachers create a more inclusive classroom through using adolescent literature. Four teachers in diverse schools throughout Mississippi used The Hate U Give by Angie Thomas …
An Applied Research On Promoting Proficiency In Fourth-Grade Reading, Deirdre Huntley
An Applied Research On Promoting Proficiency In Fourth-Grade Reading, Deirdre Huntley
Electronic Theses and Dissertations
This applied research study was conducted to promote proficiency in fourth-grade reading. There was a need for improvement in fourth-grade reading after receiving data from the school and state assessments. The study examined the implementation of specific reading and vocabulary strategies, student interventions, strengthening of teacher-student relationships, and encouraging student motivation to help students become proficient in understanding what the students were reading. Student diagnostic results and teacher interviews were utilized in this study. The findings revealed students were demonstrating advancement in reading comprehension. Due to the COVID-19 pandemic, the school building was closed in March of 2020 which impacted …
Towards A New Method Of Determining Protein Structure, Niloofar Abolhasani Khaje
Towards A New Method Of Determining Protein Structure, Niloofar Abolhasani Khaje
Electronic Theses and Dissertations
Hydroxyl radical protein footprinting (HRPF) by fast photochemical oxidation of proteins (FPOP) is a mass spectrometry-based technique that measures the apparent protein oxidation rate by freely diffusing hydroxyl radicals at different regions in a protein, and correlates changes in this apparent rate with changes in the solvent accessibility of the protein target based on quantifying the amount of oxidation of different regions of a protein. While there have been many advancements in HRPF-FPOP, oxidation measurement still suffers from high variability between measurements. High variability reduces the power statistical power this technique even in the presence of radical dosimetry measurements and …
Opinions, Attitudes, And Self-Efficacy Of Secondary School Counselors In Ramp And Non-Ramp Designated Schools And Their Work With Students With Disabilities, Christine Denise Lewis Pugh
Opinions, Attitudes, And Self-Efficacy Of Secondary School Counselors In Ramp And Non-Ramp Designated Schools And Their Work With Students With Disabilities, Christine Denise Lewis Pugh
Electronic Theses and Dissertations
The American School Counseling Association (ASCA) implemented standards that aid the professional school counselor via a comprehensive program to serve all students (ASCA, 2019). This study examines secondary school counselors working in RAMP and non-RAMP designated schools. The designation of recognized ASCA model programs (RAMP), which awards schools when they successfully implement comprehensive programs, leads one to believe that RAMP programs exhibit effectiveness, while understanding that lacking RAMP certification does not mean a comprehensive school counseling program does not exist. The current study surveyed secondary school counselors’ attitude, self-efficacy, and opinions toward work with students with disabilities. An independent samples …
Mediating Effects Of Mental Health Literacy And Stigma On The Relationship Between Mental Health Status And Psychological Help Seeking Behavior Among Collegiate Student Athletes, Brent Wade Powell
Electronic Theses and Dissertations
Student athletes experience unique demands that create specific mental health challenges, yet they tend to utilize mental health services at lower rates when compared to the general student population. Participants were 282 (174 males, 108 females) current NCAA student athletes. A mediated regression was used to determine the mediating effects of Mental Health Stigma (MHS) and Mental Health Literacy (MHL) on the relationship between Mental Health Status and Psychological Help Seeking Behavior (PHS). Results indicated a statistically significant relationship between mental health status and psychological help seeking behavior, R2 = .05, F(1, 280) = 13.74, p < .001. Mental health status predicted PHS (? = -.22, 95% CI [-.11, -.04]). A multiple regression analysis was conducted on PHS based on MHS and MHL, F(2,279) = 9.49, p < .001. MHS was a statistically significant predictor of PHS uniquely accounting for approximately 4.2% of the variance. MHL was not significant and uniquely accounted for .1% of the variance. Analysis of a supported mediation model was conducted using MHS as the single mediator. Controlling for the mediator, the direct effect indicated by the relationship between mental health status and PHS, (? = -.046, 95% CI [-.094, .007], z = -2.04, p = .04), denoting a partial mediation and small effect. The total indirect effects with the mediator was statistically significant, (? = -.028, 95% CI ([-06, -.003]), z = -2.327, p = .02, indicating a moderate effect and accounting for 61% of the model effect. Results from this study can be used to inform program development, institutional supports, and inform further research into reduction of MHS and increasing MHL. Keywords: student athletes, mental health status, mental health stigma, mental health literacy, psychological help seeking behavior
Woman Enough?: Transgender Women And Intimate Partner Violence Shelters, Parker Smith
Woman Enough?: Transgender Women And Intimate Partner Violence Shelters, Parker Smith
Electronic Theses and Dissertations
This research drawing from analysis of a Qualtrics, pre-interview survey and in-depth, semi-structured interviews with seven intimate partner violence shelter leaders across the united states examines service provision for transgender women and how these shelters rationalized inclusion or exclusion for these services. Analysis revealed that despite speaking negatively and against cisnormative public narratives of intimate partner violence that shelter leaders and their organizations actively displayed cisnormative imagery throughout their websites and did not utilize large scale outreach to transgender women to also build relationships past how transgender women might see these shelters as. Shelter leaders also discussed how their allocation …
Perceptions Of Role Conflict And Role Ambiguity Among Fraternity And Sorority Advising Professionals, Anthony E. Vukusich
Perceptions Of Role Conflict And Role Ambiguity Among Fraternity And Sorority Advising Professionals, Anthony E. Vukusich
Electronic Theses and Dissertations
Campus-based professionals in the area of Fraternity and Sorority Advising Programs (FSAP) have a known and documented high rate of attrition; more than half departing within the first five years of employment. Two recognized role stressors that are associated with high rates of turnover are role conflict and role ambiguity. Studies by Gold & Roth, 2013; Khan, Yusoff, Khan, Yasir, & Khan, 2014; Rizzo, House & Lirtzman, 1970; and Wolverton, Wolverton & Gmelch, 1999 have demonstrated that role conflict and role ambiguity are contributing factors in employee attrition across an array of industries and position types, including nurses, teachers, academic …
Design And Synthesis Of Salvinorin-Based Compounds For The Opioid Receptors., Nicholas S. Akins
Design And Synthesis Of Salvinorin-Based Compounds For The Opioid Receptors., Nicholas S. Akins
Electronic Theses and Dissertations
Opioid receptors (OR) are expressed throughout both the peripheral and central nervous system and play crucial roles in the modulation of antinociception, addiction, anxiety, and depression. Salvinorin A, the main isolate of the hallucinogenic plant Salvia divinorum, is one of the most potent naturally occurring kappa opioid receptor agonists. Salvinorin A possesses beneficial effects as a therapeutic in a variety of CNS disorders, but due to its strong hallucinating, anxiogenic effects, and short half-life(t1/2), it has never advanced to clinical trials. Instead, salvinorin A has been used as an important prototype for the development of related drug candidates. Our initial …
Acceptability, Anticipated Adherence, And Willingness To Begin Interoceptive Exposure: Examination Of The Influence Of A Values Rationale, Gina Quebedeaux Boullion
Acceptability, Anticipated Adherence, And Willingness To Begin Interoceptive Exposure: Examination Of The Influence Of A Values Rationale, Gina Quebedeaux Boullion
Electronic Theses and Dissertations
Interoceptive exposure (IE) is a treatment entailing induction of feared physiological sensations that has emerged as the most efficacious component of cognitive behavioral treatments for panic disorder. However, small-to-moderate effect sizes, wide variability in response rates, and dropout rates indicate that panic disorder treatments may benefit from modifications to improve upon retention, response rates, and symptom reduction. Patient motivation and lack of engagement have been identified as factors to intervene upon. One specific direction that has gained increasing empirical interest is the inclusion of values identification; however, research has not yet examined the influence of values on motivation to engage …
Abuse Deterrent Formulation Using Hot Melt Extrusion Technology, Vishvesh Raje
Abuse Deterrent Formulation Using Hot Melt Extrusion Technology, Vishvesh Raje
Electronic Theses and Dissertations
The purpose of the current study was to formulate hot melt extruded (HME) abuse deterrent pellets of acetaminophen(APAP), a model drug with the aid of high molecular weight hydroxypropyl methylcellulose (HPMC 4M ) and gelling agents (starch, pectin and carbopol). The formulated HME pellets were assessed for their abuse-deterrence (AD) potential using Category- 1 laboratory in-vitro evaluation standards. The pellets were examined for the particle size reduction (PSR), extraction in small volume, syringeability, thermal manipulation and dissolution for evaluating the resilience of the AD properties. Though, most of the formulation showed complete particle size reduction after grinding, grounded pellets were …
The Black Petromodernism Of Zora Neale Hurston: Energy, Race, And Mobility, Stuart Mullet
The Black Petromodernism Of Zora Neale Hurston: Energy, Race, And Mobility, Stuart Mullet
Electronic Theses and Dissertations
This thesis situates Zora Neale Hurston and the folk communities in her oeuvre within the context of modernity’s dependencies on fossil fuels. Such a disciplinary context provides an energy footing for our understandings of African American migrations in the twentieth century—which radically transformed the nation on multiple levels—and it illuminates the communal values that undergird Black approaches to petromodern forms of mobility. Furthermore, by engaging the Black spaces of the South, my argument begins filling a gap in the energy humanities. Few scholars in this field engage deeply those populations and regions that disproportionately experience the underbelly of petromodernity and …
The Role Of Year-Round Fan Engagement: A New Approach To Sport Fan Behavior, Han Soo Kim
The Role Of Year-Round Fan Engagement: A New Approach To Sport Fan Behavior, Han Soo Kim
Electronic Theses and Dissertations
Fan engagement, the substantial psychological connectedness to a specific club, team, or sport itself, is in a state of rapid transformation due to the growth of digital media. For sport organizations, managing fan engagement throughout the year is important to maximizing team revenues and sponsors’ interests. While fans consume sports differently depending on the season, the focus has been primarily on fan behavior during the in-season in the sport management literature. Thus, the purposes of this study were to (1) provide a conceptual framework of year-round fan engagement by applying the season distinction approach, (2) establish the scale of off-season …
Executive Functioning And Purpose In Life Among Emerging Adults In College, Alexis Kaylyn Liberto
Executive Functioning And Purpose In Life Among Emerging Adults In College, Alexis Kaylyn Liberto
Electronic Theses and Dissertations
Background: Executive functioning (EF) is a complex neurocognitive concept that grew from the field of neuropsychology and has been explored through various avenues. The most accepted theoretical organization of EF includes a three-factor model that is comprised of inhibition, updating, and shifting. The three-factor conceptualization can be measured through various objective EF neuropsychological assessments and self-reported levels of EF abilities. Goal-planning and organizing cognitive processes are another important facet of EF, as they involve self-regulation abilities. Individuals able to “regulate” themselves behaviorally and move towards goals tend to be more successful and move towards their purpose in life. A facet …
Applications Of Hot-Melt Extrusion (Hme) Technology And Investigation Of A Screening Tool For Hme, Gauri Deepak Shadambikar
Applications Of Hot-Melt Extrusion (Hme) Technology And Investigation Of A Screening Tool For Hme, Gauri Deepak Shadambikar
Electronic Theses and Dissertations
Hot-melt extrusion (HME), an adaptable technology, has established its position in manufacturing operations like amorphous solid dispersions, immediate and controlled oral formulations, implants and taste masked products. In recent years the industrial focus has shifted towards continuous manufacturing, thus HME is being explored for new applications. The aim of this research was to investigate the novel applications of HME by carrying out an in-depth study to understand the interaction between the process and product and to investigate a screening tool for its small-scale formulation and development.As HME consumes large amount of samples during the developmental phase, we investigated a screening …
An In-Depth Approach For Functional Oligosaccharide Analysis, Hao Liu
An In-Depth Approach For Functional Oligosaccharide Analysis, Hao Liu
Electronic Theses and Dissertations
Heparin and heparan sulfate (Hp/HS) are linear complex glycosaminoglycans (GAGs), which are involved in diverse biological processes. Although Hp/HS GAGs influence numerous physiological and pathophysiological processes, their high degree of size polydispersity and sequence microheterogeneity make structure-function characterization challenging. In addition, it is hard to understand the structures that underlie any of the various functions with MS, because of the lability of the sulfate group during tandem mass spectrometry (MS/MS) analysis. The work presented here describes an in-depth approach for functional oligosaccharide characterization including chemical derivatization of Hp to inhibit COVID-19 infection, multi-dimensional liquid chromatography (LC) fractionation method, chemical derivatization …
Designing For Democracy: How Democratizing States Design International Organizations, Marissa Wyant
Designing For Democracy: How Democratizing States Design International Organizations, Marissa Wyant
Electronic Theses and Dissertations
Building on work by Paul Poast and Johannes Urpelainen that suggests that democratizing states are more likely to form new international governmental organizations rather than join existing ones, I ask the question: how do these states design the organizations they form, and how do those design choices compare to the choices made by consolidated democracies and by nondemocracies? I focus on three design choices made by states regarding membership constraints, voting procedures, and dispute resolution processes. By comparing and analyzing founding charters, I find that democratizing states were more likely to constrain access to membership into these organizations to regional …
Development And Characterization Of Albuterol Sulfate Loaded Transdermal Patches With Hme Coupled Fdm 3d Printing, Bhavana Chivukula
Development And Characterization Of Albuterol Sulfate Loaded Transdermal Patches With Hme Coupled Fdm 3d Printing, Bhavana Chivukula
Electronic Theses and Dissertations
Albuterol sulfate is a short-acting selective Beta 2 Adrenergic agonist. It is used to treat and prevent bronchospasm associated with asthma, bronchitis, and other breathing disorders. It is known to show extensive first pass metabolism and it requires frequent dosing which makes it difficult for patients to comply. To avoid these problems, transdermal route of delivery of Salbutamol was explored. Traditional methods of preparation of transdermal drug delivery systems involve the use of solvents and have multiple processing steps. To avoid the usage of solvents and decrease the processing steps, HME Coupled FDM 3D printing can be used. Different polymers …
Analysis Of Trends And Effects Of Lifestyle Behaviors Related To Obesity Among Older Adults: Findings From The National Health And Nutrition Examination Survey (Nhanes) Between 2005-2018, Xi Jin
Electronic Theses and Dissertations
Obesity in older adults is a public health challenge in the United States and many regions of the world. This study analyzed data from the National Health and Nutrition Examination Survey (NHANES) ranging between 2005-2006 to 2017-2018 to examine associations between lifestyle behaviors and obesity, and identify trends and contributions of lifestyle behaviors in older adults. A total of 5,812 participants in a body mass index (BMI)- based obesity group and 5,655 participants in a waist circumference (WC)-based obesity group were selected for association and trend analyses. Logistic regression was applied to estimate the associations between lifestyle behaviors and obesity. …
Graphene Sand Composites And Their Applications In Water Treatment, Abdulla Nusair
Graphene Sand Composites And Their Applications In Water Treatment, Abdulla Nusair
Electronic Theses and Dissertations
Water scarcity and the emergence of new contaminants are making the world in need of renewable water resources. Slow sand filtration is looked at as an affordable and easy method to filter water with a few weaknesses such as clogging and the inability to remove complex matrix ingredients. To overcompensate these limited weaknesses, graphene-coated sand was studied. Ottawa, concrete, and masonry sand were used, using a reduction method to transform a coating of sugar into elemental carbon in N2 atmosphere at temperatures reaching 750°C. After that, the synthesized materials were activated using sulfuric acid. To verify the effectiveness of the …
Autonomy And Higher Education: Insight Into The Autonomy System In The Commonwealth Of Virginia, George Lamar Rutherford, Ii
Autonomy And Higher Education: Insight Into The Autonomy System In The Commonwealth Of Virginia, George Lamar Rutherford, Ii
Electronic Theses and Dissertations
Institutions of Higher Education (IHEs) have wrangled with state governmental agencies for decades about the role the government should assume in overseeing campus operations. IHEs continue to argue that government intrusion impedes efficient IHE operation. Government agencies counter that IHEs are provided tax dollars to complete the job of educating the states’ citizens and that IHEs must abide by the rules and regulations set by the state. However, over the last two decades, state funding for IHEs is at an all-time low; yet governments still dictate how IHEs operate. With decreased state funding, IHEs sought to replace those funds by …
Sustained Delivery Of Moxifloxacin For Ocular Applications., Ruchi Amit Thakkar
Sustained Delivery Of Moxifloxacin For Ocular Applications., Ruchi Amit Thakkar
Electronic Theses and Dissertations
Moxifloxacin is available as a marketed solution (Vigamox(R) which has to be administered 3 or more times a day leading to poor patient compliance and low ocular bioavailability. The overall goal of this research was to use formulation strategies and develop patient compliant dosage forms of moxifloxacin which are sustained-release so as to improve its retention and thereby ocular bioavailability. The first strategy that was explored was to develop sustained release inserts of moxifloxacin hydrochloride using hot-melt extrusion. The inserts showed sustained release and antibacterial activity up to 24h and could potentially be a once-a-day application and improve patient compliance …
Exploring The Impact Of Leadership Values And Practices To Support Equity And Social Justice In An Urban School, Susan-Marie Farmen
Exploring The Impact Of Leadership Values And Practices To Support Equity And Social Justice In An Urban School, Susan-Marie Farmen
Electronic Theses and Dissertations
This qualitative case study explores the leadership values and practices of a principal in a sixth through twelfth-grade school in the Rocky Mountain West to determine how leadership values and practices support the implementation of equitable and socially just practices in the school. Five key themes emerged: (a) equity as a Black/non-Black construct; (b) a lack of knowledge and awareness of the historical contexts of marginalized populations; (c) moral courage for all members of the school; (d) equity as an initiative or program; (e) resistance to deep equity work. From these themes, I devise three recommendations to support substantial and …
An Lre Placement Loophole: A Critical Policy Analysis Of Lre Placement In Defining Disproportionality Of Culturally And Linguistically Diverse Students In Special Education, Arti Sachdeva
Electronic Theses and Dissertations
The policies adopted by the Exceptional Children’s Education Act (2016) enabled disproportionality within LEAs by overlooking undocumented classroom removal practices, underestimating the monitoring and reporting criteria, and overlooking non-dominant cultural and linguistic groups within the Colorado community. In this critical policy analysis, I used quantitative methods to analyze and explore the difference between the odds ratio calculation of culturally and linguistically diverse students (CLDS) in special education with a least restrictive environment (LRE) of 40% and greater compared to Colorado’s acceptance of the federal mandate of the minimum requirement of the student LRE of less than 40% and alternate school …
Culturally Responsive School Leadership Agility: A Journey Through Critical Self-Reflection, Deborah Mckelvey Brown
Culturally Responsive School Leadership Agility: A Journey Through Critical Self-Reflection, Deborah Mckelvey Brown
Electronic Theses and Dissertations
This study examined how school leaders can differentiate their approach using a self-reporting psychometric instrument called the Emergenetics® Profile when engaged in critical self-reflection. Using a multiple case study approach, three urban school leaders engaged in the deconstructing and reconstructing of knowledge frameworks specific to deficit thinking. The Emergenetics Profile served as a lens to critically self-reflect in order to differentiate their approach to the disrupt deficit thinking practices in their schools (Browning 2007; Khalifa, 2018; Shields, 2018). This study integrated these insights from critical self-reflection and the awareness gained by school leaders through their Emergenetics preferences to change their …
Sea Level Rise Impacts On The City Of Cape Coral, Southwest Florida From 2020 To 2050, Jawata Afnan Saba
Sea Level Rise Impacts On The City Of Cape Coral, Southwest Florida From 2020 To 2050, Jawata Afnan Saba
Electronic Theses and Dissertations
Sea level rise, a consequence of global climate change, has been affecting the U.S. coasts with flooding and exacerbated storm surges. Florida is highly vulnerable because it has low-lying topography and coastlines on both the Atlantic Ocean and the Gulf of Mexico. The City of Cape Coral, Southwest Florida, is known as a ‘waterfront wonderland’ with 400 miles of canals that provide waterfront property to the residents. Most of the canals are navigable, and many have access to the Gulf of Mexico. The city is vulnerable to sea level rise because of its canals, site between the Matlacha Pass and …
Genetically Modified Corn Diffusion And Biofuel Usage: Impacts On Corn Belt Cropping Systems Changes, Kenneth Annan
Genetically Modified Corn Diffusion And Biofuel Usage: Impacts On Corn Belt Cropping Systems Changes, Kenneth Annan
Electronic Theses and Dissertations
The adoption of genetically modified (GM) crops, the rise of ethanol production that produced an additional derived demand for corn, and the increasingly prominent position of corn and soybeans in crop rotations embody major changes in U.S. agriculture during the past decades. This study investigates the linkages among these developments in two ways. First, we look at how biotechnology and biofuels have influenced cropping system changes in the Corn Belt region of the United States, using state-level data from 2000 to 2019. Second, we investigate the determinants of corn acreage intensification levels and heterogeneity at the state level using data …
Quantifying The Impacts Of An Integrated Crop-Livestock System On Plant Nutrient Accumulation, Crop Yield, And Economic Performance, Teerath Singh Rai
Quantifying The Impacts Of An Integrated Crop-Livestock System On Plant Nutrient Accumulation, Crop Yield, And Economic Performance, Teerath Singh Rai
Electronic Theses and Dissertations
Integrated crop-livestock systems (ICLs), if managed properly, have the potential for enhancing crop production and economics. Cover crops in ICL can be grazed to provide feed for livestock and improve nutrient recycling. This dissertation focused on assessing the impacts of ICL on crop yield and economics using field and modeling studies. Specific objectives of this dissertation are: (i) evaluating the impacts of the ICL on crop yield, and economic performance in a 3-yr oat (Avena sativa L.) – maize (Zea mays L.) – soybean (Glycine max (L.) Merr.) rotation, (ii) assessing the impacts of the ICL on maize biomass accumulation, …