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An Integrative Analysis On The Role Of Notch1 And Notch3 In Musculoskeletal Disease, Haydee Magdalena Torres
An Integrative Analysis On The Role Of Notch1 And Notch3 In Musculoskeletal Disease, Haydee Magdalena Torres
Electronic Theses and Dissertations
Notch signaling is an evolutionarily conserved signaling pathway involved in cell fate decisions and cell renewal of multiple systems, including skeletal and muscle homeostasis. As the multifunctional nuclear complex of Notch1 is essential for its pathological function, identifying these interacting partners represents a potentially broad range of druggable vulnerabilities. We have completed a BioID proteomics study and found a large set of nuclear proteins associated with NOTCH1, including transcriptional regulators and epigenetic modulators, of which Histone Deacetylase 1 (HDAC1) is a promising interacting partner of Notch1. Our Cytoscape analysis predicted HDAC1 to be a top critical node in an activated …
Bio-Inspired Materials For Electrochemical Sensors, Matthew Joseph Hummel
Bio-Inspired Materials For Electrochemical Sensors, Matthew Joseph Hummel
Electronic Theses and Dissertations
Electrochemical biosensors are a rapidly growing research area that has greatly improved its specificity, accuracy, and precision in the detection of biomolecules in contemporary literature and industry alike. Typically, these systems exist in a three-electrode conformation with a working electrode functioning as the anode, a counter electrode functioning as the cathode, and a reference electrode allowing for the control of potential in the system. The method by which these sensors work is through the sharing of electrons via redox reactions with the target molecule and the working electrode or modifications on its surface. By exploiting the function of biomaterials that …
Metal-Organic Frameworks As Bacteria Mimicking Delivery Systems For Tuberculosis, Ailin Guo
Metal-Organic Frameworks As Bacteria Mimicking Delivery Systems For Tuberculosis, Ailin Guo
Electronic Theses and Dissertations
Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis (M.tb), with an estimated 1.5 million deaths and 10 million infections each year. Although TB can be effectively treated with antibiotics, because of the complications and length of treatment, many people fail to complete the treatment which exacerbates the emergence of drug-resistant M. tb strains. The goal of this work is to develop biomimetic particles as host-directed therapy to target the infected macrophages. Two types of metal-organic frameworks (MOFs), MIL-100(Fe) and MIL-88A(Fe) were developed for bacteriamimicking particles. As a proof-of-concept, Mannose was selected as a ligand to target macrophages because …
An Exploration Of The Effects Of An Early Postpartum Intravenous Infusion With Carnosic Acid On Physiological Responses Of Transition Dairy Cows, Tainara Michelotti
An Exploration Of The Effects Of An Early Postpartum Intravenous Infusion With Carnosic Acid On Physiological Responses Of Transition Dairy Cows, Tainara Michelotti
Electronic Theses and Dissertations
The transition period is commonly defined as the last 3 wk before parturition to 3 wk after parturition. It is the most critical stage of the lactation cycle of high-producing dairy cows. The period consists of a complex interplay of metabolic and hormonal adaptations, inflammation, and immune activation. During the transition period, dairy cows commonly face oxidative stress, an underlying factor for dysfunctional immune response and enhanced inflammation, which can further increase the susceptibility of dairy cattle to health disorders and decrease productivity. In the last few decades, there has been an increased interest in studying alternative natural compounds with …
Auxin-Based Herbicide Program And Rhizobia Application For Weed Control And Nodulation Potential In Auxin Tolerant Soybean, Joy Amajioyi
Auxin-Based Herbicide Program And Rhizobia Application For Weed Control And Nodulation Potential In Auxin Tolerant Soybean, Joy Amajioyi
Electronic Theses and Dissertations
Foliar-applied Bradyrhizobia to V4 soybean has been reported to increase yield up to 5%. However, a stand-alone product application may not be practical. Applying with other treatments such as post-emergence herbicide application may be economical but herbicide and/or additives may be deleterious to rhizobial growth. A laboratory study investigated the impact of herbicides (glyphosate and dicamba), additives (an oil to improve absorption and spreading; and AMS used to overcome hard water impacts on glyphosate), and herbicide + additives on bacterial growth. Optical density (OD) measurements at the wavelength of 650 nm assessed solution turbidity, a surrogate measure of bacterial growth. …
Lessons Learned Through Time: An Examination Of The 1918 Influenza Pandemic And The Covid-19 Crisis, Stephanie Lee Poiroux
Lessons Learned Through Time: An Examination Of The 1918 Influenza Pandemic And The Covid-19 Crisis, Stephanie Lee Poiroux
Electronic Theses and Dissertations
The purpose of the present study is to compare the United States’ federal and state response to the 1918 Influenza Pandemic and the 2020 COVID-19 Crisis and the role of bureaucracy. Utilizing Qualitative Content Analysis, I examined 300 newspaper articles from The New York Times, The Clarion-Ledger, and The Daily Clarion-Ledger from July 1, 1918, to December 31, 1918, and March 1, 2020, to August 31, 2020. Through this analysis, I found that federal and state governments reacted to the 1918 flu very quickly, whereas the response to COVID-19 was hindered due to political in-fighting that impeded the bureaucracy and …
Effect Of Chronic Pain On Prospective Memory Performance, Alexander Joseph Kuka
Effect Of Chronic Pain On Prospective Memory Performance, Alexander Joseph Kuka
Electronic Theses and Dissertations
Chronic pain is among the most widespread and disabling conditions worldwide. In the United States, approximately 50 million people suffer from chronic pain, and nearly half that number experience daily chronic pain. Diagnostic testing, treatments, and operations related to chronic pain cost Americans over $600 billion annually. Prospective memory, the process by which people remember to perform an action in the future after a delay, appears to be affected by the experience of pain, especially when a prospective memory task is more cognitively demanding. While self-report studies of individuals with chronic pain suggest that pain adversely affects both their retrospective …
The Accuracy Of Subjective Load Parameters In Comparison To Analytical Load Measurments In Ncaa Division I Women’S Volleyball, Katherine Pierce
The Accuracy Of Subjective Load Parameters In Comparison To Analytical Load Measurments In Ncaa Division I Women’S Volleyball, Katherine Pierce
Electronic Theses and Dissertations
Monitoring the work load of athletes in both an individual and team setting has become a commonplace practice in today’s age of sports. However, this practice can look different depending on the physical demands of the sport. Specifically, in volleyball, an inertial measurement unit, known as Vert, can be utilized to track the number of jumps performed by players, in addition to other jump related variables. While Vert serves as an effective way of objectively measuring jump frequency among players, other ways in which jump frequency can be estimated are needed for teams and players without Vert. Therefore, this study …
The Ghost Town: An Autoethnographic Study On The Effects Of Loss And Trauma On A Saudi Arabian International Student’S Well-Being, Salman J. Alzowibi
The Ghost Town: An Autoethnographic Study On The Effects Of Loss And Trauma On A Saudi Arabian International Student’S Well-Being, Salman J. Alzowibi
Electronic Theses and Dissertations
We all have fought on grief’s battleground; some of us started at early ages, while others during their developmental age, teen’s years, or later in their adulthood. All of them are valuable resources and sites of knowledge that need to be explored. Yet, recent studies reduced grief into clinical psychological well-being. However, as I lived these experiences, trauma, loss, and grief impact all well-being dimensions. Grief intersects with large structures (e.g., social, economic, cultural, locations, etc.); all these components impact our way of grief how socially displayed (mourning). This dissertation encapsulates my personal experience elevating it to an academic work …
Uncovering An Alternative Social Structure To Social Dominance: A Blend Of Ethnography And Community Based Participatory Research, Andrew A. Fox
Uncovering An Alternative Social Structure To Social Dominance: A Blend Of Ethnography And Community Based Participatory Research, Andrew A. Fox
Electronic Theses and Dissertations
This study investigated social structures that are alternative to the prevailing assumption of Social Dominance Theory (SDT), which is that all human interaction is based on social hierarchies. The implications of social dominance impact health at an institutional, interpersonal, and intrapersonal level. The intersection of these levels of social dominance cause health disparities that perpetuate gaps between populations. This study explored one community organizing group who is challenging social dominance by creating alternative social structures. The methods of this study included Community Based Participatory Research (CBPR) and Arts Based Research (ABR) as ways to generate middle-range theorizing and attempt to …
Development, Optimization, And In Vitro Characterization Of Different Anesthetic Wound Products, Alia Alshammari
Development, Optimization, And In Vitro Characterization Of Different Anesthetic Wound Products, Alia Alshammari
Electronic Theses and Dissertations
ABSTRACTAcute and chronic wounds can be a significant source of pain. In the past, pain associated with chronic wounds has been perceived as an inevitable complication of wound care. Fortunately, recent approaches in wound care have developed strategies to prevent and reduce pain when carrying out wound care. Local anesthetics have been used to that end. Lidocaine is the most widely used topical anesthetic in wound care. However, literature on topical Lidocaine has focused almost exclusively on the clinical application on intact skin. This dissertation aims to advance our understanding of anesthetic wound product formulation and development. Anesthetic wound ointments …
Sleep And Health-Related Quality Of Life Among Persons With Parkinson’S Disease And Their Caregiverssleep And Health-Related Quality Of Life Among Persons With Parkinson’S Disease And Their Caregivers, Sushmitha Inguva
Electronic Theses and Dissertations
This dissertation aimed at filling gaps in the body of Parkinson’s disease (PD) and sleep literature by synthesizing and appraising current knowledge on the influence of sleep on health-related quality of life (HRQoL) in persons with Parkinson’s (PWP) and their caregivers, conducting a psychometric evaluation of a HRQoL instrument among PWP, and applying a novel method to assess the dyadic relationship between sleep and HRQoL in PWP and their caregivers. First, the systematic literature review results showed that nocturnal and diurnal sleep problems among PWP are strong predictors of their HRQoL. Additionally, studies that focused on caregiver outcomes showed that …
The Role Of Acetylcholine In Attention And Lapses In Attention In Rats Using The Mode And Deviation From Mode Of Reaction Time Latency, Scott Lee Mitchell
The Role Of Acetylcholine In Attention And Lapses In Attention In Rats Using The Mode And Deviation From Mode Of Reaction Time Latency, Scott Lee Mitchell
Electronic Theses and Dissertations
Attention Deficit-Hyperactivity Disorder (ADHD) is currently the neurodevelopmental disorder most commonly diagnosed in children in the United States, and one of the defining characteristics of ADHD is inattention. Inattention is marked by increased lapses in attention, and when assessed clinically, it has been highly correlated with reaction-time variability (RTV). Evidence from the human/clinical literature has shown an inherently higher RTV to be the primary quantitative indicator of an ADHD diagnosis. Reaction-time distributions are characterized by an asymmetrical rightward skew, and because of the prevalence of this presentation, it has been theorized that the distribution peak and skew represent separate phenomena, …
The Perceptions Of Rural College Students On The Impact Of High School College Counseling On College Choice, Tommy Glen Walker
The Perceptions Of Rural College Students On The Impact Of High School College Counseling On College Choice, Tommy Glen Walker
Electronic Theses and Dissertations
Making decisions about college can be challenging for rural students. Guidance counselors and other adults influence these decisions because of their close relationships in high schools and communities. Since rural students are coached into pursuing college as a mechanism for obtaining a better life, it is beneficial to explore their lived experiences regarding college counseling and college choice. This dissertation in practice explores the perceptions of rural college students on the impact of high school college counseling on college choice.
Development Of Bio-Based Nanocomposites For Biosensor And Indicator Applications In Smart Food Packaging, Abdus Sobhan
Development Of Bio-Based Nanocomposites For Biosensor And Indicator Applications In Smart Food Packaging, Abdus Sobhan
Electronic Theses and Dissertations
Smart food packaging based on biosensors has been attracting more and more interest to the industrial community because of the concerns of food quality and safety. A food packaging with biosensor has a scope to enable real-time monitoring of microbial breakdown products of packaged foods. Furthermore, one of the biggest challenges in implementing biosensor for smart packaging materials is the development of bio-sensing active materials that can leverage their electrical, thermal, biodegradable and other functional properties. In this regard, nanocellulose-based activated carbon (NAC) nanocomposite was developed using the activated carbon and nanocellulose gel using the casting method with their different …
A Hydrologic Study Of Climate Variability In Arid Region, Abdullah Alzaydani
A Hydrologic Study Of Climate Variability In Arid Region, Abdullah Alzaydani
Electronic Theses and Dissertations
Climate variability is an important subject to study. It is the change of climate over a long time, which could have a positive or negative impact on humans, soil, and wildlife. Many environments, such as arid environment could be affected by climate variability. The research goal is studying and examining climate variability in arid environment. The research includes three different studies. The first study includes reviewing and understanding of climate variability over extended time through existing studies in arid environments. In addition, this study includes knowledge about climate negative or positive impact on the environment. This study will be reviewing …
Free-Living Diazotrophs And The Nitrogen Cycle In Natural Grassland Revealed By Culture Dependent And Independent Approaches, Amrit Koirala
Free-Living Diazotrophs And The Nitrogen Cycle In Natural Grassland Revealed By Culture Dependent And Independent Approaches, Amrit Koirala
Electronic Theses and Dissertations
Biological nitrogen fixation contributes to half of the global supply of nitrogen to the biosphere. It is carried out by a diverse group of prokaryotes called diazotrophs via the nitrogenase enzyme. Nitrogen fixation research is focused on the narrow group of symbiotic diazotrophs, and the vast majority of free-living diazotrophs which contribute significantly to fixed nitrogen are yet to be explored. The goal of this research was to access phylogeny of diazotrophs considering the most up-to-date genomic information and apply that knowledge to understand the diversity of free-living diazotrophs in a natural grassland ecosystem, both by culture dependent and independent …
Development Of Efficient Wide-Bandgap Perovskite Solar Cells With Composition And Interface Engineering, Khan Mamun Reza
Development Of Efficient Wide-Bandgap Perovskite Solar Cells With Composition And Interface Engineering, Khan Mamun Reza
Electronic Theses and Dissertations
Metal halide perovskites are considered the most promising solar energy technology because of their distinct properties, such as defect tolerance, low cost, easy fabrication due to solution-processibility, band tunability, etc. Due to these properties, the efficiency of perovskite solar cells reaches more than 25% and approaches the limit of singlejunction within last few years. To increase the efficiency further in a more cost-effective way, double junction tandem solar cells with an efficient ‘top’ wide-bandgap cell is desired. But wide-bandgap perovskites still face some critical issues, such as poor morphology, smaller grain size, the formation of excessive lead halides, light-induced halide …
Association Between Prepregnancy Obesity And Health Behaviors, Adverse Conditions, And Birth Outcomes In South Dakota, Lily Sanderson
Association Between Prepregnancy Obesity And Health Behaviors, Adverse Conditions, And Birth Outcomes In South Dakota, Lily Sanderson
Electronic Theses and Dissertations
Introduction: Prepregnancy obesity is associated with an increased risk for various adverse outcomes for mother and fetus. These adverse associations exist within the realms of preconception health, prenatal health, birth outcomes, and postnatal health.
Methods: This retrospective cohort study used data from the South Dakota Pregnancy Risk Assessment Monitoring System (SD PRAMS) survey, which is an ongoing statebased surveillance system of maternal behaviors, attitudes, and experiences before, during, and shortly after pregnancy. The 2017 and 2018 SD PRAMS sampled a total of 3,805 mothers who were randomly selected from birth certificate records to be representative of all South Dakota women …
Veracious Verdicts: An Expansion Of Cognitive-Experiential Self-Theory In Jury Decision-Making Using Attribution Theory, Jade E. Larson
Veracious Verdicts: An Expansion Of Cognitive-Experiential Self-Theory In Jury Decision-Making Using Attribution Theory, Jade E. Larson
Electronic Theses and Dissertations
As a pillar in our judicial system, the courts utilize almost ten million citizens each year for jury service. As a result, the courts are faced with issues of inconsistency and unpredictability. This study aims to examine some factors that significantly influence jury decision-making by investigating cognitive experiential self-theory (CEST) as a jury decision-making model, unified with attribution theory to better predict verdict outcomes. An online survey was distributed to 121 participants. The respondents were asked to read a civil trial case presentation; they were then randomly divided into two conditions (high and low unrelated detail eyewitness testimony). The testimonies …
The Plight Of Valinor: A Historically Informed Perspective On The Future Development Of Space Law And Potential Exercise Of Self-Determination By Human Settlements On Mars, Marshall David Mckellar
The Plight Of Valinor: A Historically Informed Perspective On The Future Development Of Space Law And Potential Exercise Of Self-Determination By Human Settlements On Mars, Marshall David Mckellar
Electronic Theses and Dissertations
Breathable air, water, food, shelter, sleep: these are the five basic requirements for human survival. Providing these basics to a single person living on Earth is a challenge; providing them to 1,200 people living in the harsh Martian environment is a different matter entirely. Nonetheless, in 2047, SpaceX successfully constructed Valinor—the first human inhabited scientific settlement on Mars—by transporting hundreds of scientists and engineers, along with countless scientific experiments and technologically advanced survival equipment, to the red planet. Each year saw more successful missions to Valinor and the world community grew more excited about the reali-zation of humanity’s expansion into …
Effects Of Acute Exercise Intensity On Source Episodic Memory: Considerations By Cardiorespiratory Fitness, Brandon Thomas Rigdon
Effects Of Acute Exercise Intensity On Source Episodic Memory: Considerations By Cardiorespiratory Fitness, Brandon Thomas Rigdon
Electronic Theses and Dissertations
Prior research suggests that behavioral (e.g., acute exercise) and psychological factors (e.g., metamemory; monitoring and control of one’s memory processes) may influence memory function. However, there is conflicting results on the optimal intensity of acute exercise to enhance memory and whether acute exercise can also enhance metamemory. Further, very limited research has evaluated whether acute exercise can influence source episodic memory. The primary objective of this study was to evaluate whether there is an intensity-specific effect of acute aerobic exercise on source episodic memory and metamemory accuracy. A secondary objective was to evaluate if cardiorespiratory fitness moderates this potential relationship. …
The Relationship Between Head Coaching Change And Donations To Intercollegiate Athletic Departments, Michael Paulus
The Relationship Between Head Coaching Change And Donations To Intercollegiate Athletic Departments, Michael Paulus
Electronic Theses and Dissertations
Intercollegiate athletic departments encounter unique challenges as organizational units of higher education. Among these challenges is generating revenue to support the rising expenses of operating programs, funding coaches’ salaries, and investing in facilities. Many athletics departments generate revenue by fundraising through donor-based seating programs, philanthropic engagement, and stewardship benefits associated with levels of support. While various factors within an athletics organization can influence fundraising, the important position of head coaches is one of them. These visible positions can play a key role in influencing ticket sales, fan interest, and donations, thereby contributing to the financial viability of the entire organization.This …
African American College Students First Experiences In Counseling, Melissa Denise Spencer
African American College Students First Experiences In Counseling, Melissa Denise Spencer
Electronic Theses and Dissertations
African Americans have experienced mistreatment at the hands of the medical community. Knowledge of the Tuskegee Experiment and the travesties done by J. Marion Sims to slave women have been passed down through the generations causing cultural skepticism of the medical field, subsequently hindering African Americans from seeking medical services. This historical legacy of maltreatment has caused African Americans to seek medical help at a lower rate than their majority counterparts. African American college students seek out mental health services at a much lower rate than White students while experiencing mental health symptoms at the same or sometimes higher rate. …
Elementary School Counselors' Experiences Working With Children Who Self-Harm, Maegan Tatum
Elementary School Counselors' Experiences Working With Children Who Self-Harm, Maegan Tatum
Electronic Theses and Dissertations
Elementary-aged children struggle with low self-esteem, are often impulsive, and struggle to develop appropriate coping skills. As such, many children have begun to experiment with self-harm. Because children spend a great deal of time in school, school counselors are often the first to know that a student has self-harmed. Although school counselors have extensive experience working with students who self-harm, most school counselors indicate a need for more training and implementation of school district policies regarding self-harm. Additionally, current literature focuses on the experiences of middle and high school counselors because self-harm and NSSI are primarily noted in adolescents. In …
The Perception And Strategies Of Building Rapport With Children With Autism Spectrum Disorder Via Telepractice, Anna Cathryn Wall
The Perception And Strategies Of Building Rapport With Children With Autism Spectrum Disorder Via Telepractice, Anna Cathryn Wall
Electronic Theses and Dissertations
Telepractice is a growing method in providing services in the profession of Speech-Language Pathology. One question with this growing method is, how do we build rapport when using telepractice? In this study, we intended to find what pediatric SLPs' perceptions and strategies of building rapport via telepractice is with children with autism spectrum disorder (ASD) ages 5-12, and children’s age was considered as an influential factor. While previous studies have focused on perceptions, we wanted to know what SLPs are doing in order to build rapport with their clients when using telepractice. We reached out to 223 SLPs and there …
Computational Modeling Of Non-Active Functional States Of The Cannabinoid Receptor 1 And Its Ligands, Ayooluwa Olufunmi Aderibigbe
Computational Modeling Of Non-Active Functional States Of The Cannabinoid Receptor 1 And Its Ligands, Ayooluwa Olufunmi Aderibigbe
Electronic Theses and Dissertations
The cannabinoid receptor 1 (CB1) is a class A G-protein coupled receptor that is implicated in a variety of physiological processes, such as energy homeostasis, appetite regulation, cognition and motor control, and mood regulation. CB1 is widely distributed throughout the body, but is mainly expressed in the brain. Molecules that reduce CB1 signaling exhibit anti-obesity properties due to their effect in reducing appetite and body weight gain. However, the consequence of reducing CB1 signaling in the CNS includes adverse neuropsychiatric effects such as depression and suicidal ideation. Two methods of scientific interest for developing CB1 antagonists as anti-obesity drugs are …
Exploring Student Parent Experiences With University Policies And Practices, Chelsea Baddley
Exploring Student Parent Experiences With University Policies And Practices, Chelsea Baddley
Electronic Theses and Dissertations
This thesis explores the experiences of student parents from the University of Mississippi and examines their perceptions of university policies and practices. In addition, this study gathers the perceptions from university staff members that occupy student support roles across the university on the types of issues they think student parents at this university face and the support that is available to student parents through policies and practices. I focus on one case study, the University of Mississippi. A total of 10 semi-structed, in-depth interviews were conducted with one current student parent, four recently graduated student parents, and five university staff …
An American Pilgrimage: The 1968 Poor People's Campaign Mule Train As Prophetic Social Performance, Cheston M. Bush
An American Pilgrimage: The 1968 Poor People's Campaign Mule Train As Prophetic Social Performance, Cheston M. Bush
Electronic Theses and Dissertations
In late spring of 1968, the Southern Christian Leadership Conference (SCLC) launched a nationwide demonstration known as the Poor People’s Campaign in an effort to overcome poverty. Nine caravans representing people from around the country converged in the Capitol to petition Congress for programs that would broaden opportunities for poor Americans. This work examines the Mississippi contingent of the campaign, the Mule Train caravan, that consisted of roughly 150 people who traveled in 15 covered wagons pulled by about 40 mules. The Mule Train left Marks, Mississippi on May 13 and arrived in Washington, D.C. in time for a June …
Economic Development Policy And Economic Growth In The American States, Mohammed Shariful Islam
Economic Development Policy And Economic Growth In The American States, Mohammed Shariful Islam
Electronic Theses and Dissertations
The American states routinely adopt various economic development policies but those policies do not always contribute to economic growth in the state. Scholars identify several reasons to explain why the policies do not always work. First, policies that do not address market demand; rather, provide economic incentives to bring inward industrial investments do not contribute to economic growth because the cost it takes to create jobs by such industrial recruitments is too high. Second, policies that are adopted out of inertia chosen from traditionally practiced policies do not work because they are not evaluated for their effectiveness in terms of …