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Development And Validation Of Biosafety Climate Scale And Survey-Based Analyses Of Safety Perceptions In Biological Research And Teaching Laboratories At Public Universities In The Usa., Sivarchana Mareedu
Electronic Theses and Dissertations
Biosafety plays a key role in ensuring safety of researchers’ as well as the public from unintentional exposures to infectious agents. However, the occurrence of lab acquired infections, exposures, and safety lapses in biological laboratories underscores challenges in biosafety program management. The raise in emerging and reemerging infectious diseases and the ongoing COVID-19 pandemic reiterates the need for biosafety and research community to work together. Literature recommends the application of safety climate in measuring safety culture. The goal of this dissertation is to quantify biosafety climate and examine associated factors to understand the gaps between research and biosafety professionals in …
The Impact Of Criminal Justice Involvement: Examining Experiences In A Housing First Program., Amanda N. Denton
The Impact Of Criminal Justice Involvement: Examining Experiences In A Housing First Program., Amanda N. Denton
Electronic Theses and Dissertations
Individuals who come into contact with the criminal justice system are more likely to experience housing instability and homelessness, which, in turn, increases the likelihood of subsequent criminal justice involvement. Due to a lack of federal funding, as well as disjointed and inconsistent policies regarding eligibility criteria, people with criminal records are unlikely to receive federal rental assistance. While the exclusion of people with criminal histories is presented as necessary to protect communities and residents from crime, improving access to stable housing may reduce recidivism, incarceration rates, and correctional costs and increase public safety. The present study examined the differences …
Rapid Annealing Of Perovskite Solar Cell Thin Film Materials Through Intense Pulse Light., Amir Hossein Ghahremani
Rapid Annealing Of Perovskite Solar Cell Thin Film Materials Through Intense Pulse Light., Amir Hossein Ghahremani
Electronic Theses and Dissertations
Perovskite solar cells (PSCs) have garnered a great attention due to their rapid efficiency improvement using cheap and solution processable materials that can be adapted for scalable high-speed automated manufacturing. Thin film perovskite photovoltaics (PVs) are typically fabricated in an inert environment, such as nitrogen glovebox, through a set of deposition and annealing steps, each playing a significant role on the power conversion efficiency (PCE), reproducibility, and stability of devices. However, atmospheric processing of PSCs would achieve lucrative commercialization. Therefore, it is necessary to utilize materials and methods that enable successful fabrication of efficient PSCs in the ambient environment. The …
Concurrent Reporting Of Adverse Childhood Experiences Among Perspectives Of Adolescents And Caregivers., Katie J. Berghuis
Concurrent Reporting Of Adverse Childhood Experiences Among Perspectives Of Adolescents And Caregivers., Katie J. Berghuis
Electronic Theses and Dissertations
The consequences of Adverse Childhood Experience (ACE) events in youth have predominantly been studied through retrospective studies that assess adults’ first 18 years of life or caregiver report of ACEs in youth. Reliance on only caregiver report to discern ACEs is a limitation amongst prior studies as research has found that caregivers tend to underestimate ACEs among their children, and there is even a greater discrepancy of reporting between caregivers and youth 12 years and older. Therefore, this study investigated concurrent reporting of self-report ACE scores in adolescents – defined in this study as 12 to 20 years old – …
A Qualitative Study Of 129 Police Lethal Force Incidents In 2016 Examining Participant Behavior Relating To Mental Illness That Contributes To The Use Of Lethal Force., Edward H. Byers
Electronic Theses and Dissertations
This multi-case, exploratory research study examined videos and related news media articles of lethal police shootings and found commonalities and possible contributing factors. Videos and informational articles posted on news media websites in the public domain were used in a qualitative content analysis to identify common elements in police lethal force incidents. The results of this study revealed contributing behaviors by the participants related to mental illness that contribute to lethal force. The decision to use lethal force by a police officer is framed using four analytical themes.
Metabolic-Epigenetic Regulation Of Macrophage Polarization., Jordan T. Noe
Metabolic-Epigenetic Regulation Of Macrophage Polarization., Jordan T. Noe
Electronic Theses and Dissertations
Tumor-associated macrophages polarized to an M2 phenotype (M2-TAMs) promote neo-angiogenesis, tumor-stromal matrix remodeling, and immuno-evasion, which, collectively, contribute to immunotherapeutic resistance and reduced cancer patient survival. Highly glycolytic “Warburg” cancer cells produce lactate that independently drives naïve M0→immunosuppressive M2 (M0→M2) macrophage polarization, but the mechanisms have not been fully elucidated. The atypical cytokine macrophage migration inhibitory factor (MIF) is a fundamental underlying requirement for immunosuppressive M2 macrophage polarization. Still, it is unknown whether a molecular link exists between lactate-supported and MIF-dependent M2 macrophage polarization. Using a combination of gene expression assays, chromatin immunoprecipitation, and metabolomic analyses, we identified that M2 …
Implicit Theories As A Moderator Between Religious Commitment And Forgiveness Among Muslims Experiencing A Religious Identity Offense., John Michael Hart Ii
Implicit Theories As A Moderator Between Religious Commitment And Forgiveness Among Muslims Experiencing A Religious Identity Offense., John Michael Hart Ii
Electronic Theses and Dissertations
A recurrent finding in the literature on the relationship between religion and forgiveness is that religious people tend to describe themselves as forgiving while reporting less forgiveness in response to actual offenses (Davis, Worthington, Hook, & Hill, 2013; McCullough & Worthington, 1999). Scholars have suggested moderating factors may explain this discrepancy (Worthington et al., 2010), though the existing literature has been criticized as limited because much of the research is based on Christian samples (Carlisle & Tsang, 2013; Davis et al., 2013). Implicit theories, which have previously been found to be associated with forgiveness and theorized to be related to …
A Comparative Study Of The Organizational Culture Of A South Korean And Us High School Athletic Department., Youngjik Lee
A Comparative Study Of The Organizational Culture Of A South Korean And Us High School Athletic Department., Youngjik Lee
Electronic Theses and Dissertations
In South Korea, many high school athletics practitioners are interested in adapting US high school athletics policies to South Korean high school athletics. However, due to the cultural differences in the overall systems and environments of high school athletics in each country, directly applying US high school athletic policies does not always fit in South Korea. The purpose of this study was to examine and compare the perceptions of principals and athletic directors of the organizational cultures of a high school athletic department in South Korea and in the USA. Also, this study examined the effect of the organizational culture …
Mass Spectrometry Based Metabolomics And Lipidomics., Fang Yuan
Mass Spectrometry Based Metabolomics And Lipidomics., Fang Yuan
Electronic Theses and Dissertations
Metabolomics and lipidomics studies are important to understand living organisms at the molecular level. In this dissertation, I conducted various untargeted and targeted metabolomics and lipidomics studies using mass spectrometry based analytical platforms. Firstly, I investigated the androgen depletion effects on fecal metabolites in a mouse model of systemic lupus erythematosus and metabolite biomarkers for colorectal cancer using two-dimensional gas and liquid chromatography-mass spectrometry. Secondly, I investigated the relationship between gut microbiota-mediated resistance and susceptibility to malaria and the production of short-chain fatty acids using gas chromatography-mass spectrometry. Thirdly, I developed a high-throughput liquid chromatography-mass spectrometry method to profile long-chain …
Bayesian Variable Selection Strategies In Longitudinal Mixture Models And Categorical Regression Problems., Md Nazir Uddin
Bayesian Variable Selection Strategies In Longitudinal Mixture Models And Categorical Regression Problems., Md Nazir Uddin
Electronic Theses and Dissertations
In this work, we seek to develop a variable screening and selection method for Bayesian mixture models with longitudinal data. To develop this method, we consider data from the Health and Retirement Survey (HRS) conducted by University of Michigan. Considering yearly out-of-pocket expenditures as the longitudinal response variable, we consider a Bayesian mixture model with $K$ components. The data consist of a large collection of demographic, financial, and health-related baseline characteristics, and we wish to find a subset of these that impact cluster membership. An initial mixture model without any cluster-level predictors is fit to the data through an MCMC …
“And The Next Day, You Are In Charge”: Policy Recommendations Stemming From A Qualitative Investigation Into The Professional Development Of Early Career Peer Support Specialists In Kentucky., Diane Zero
Electronic Theses and Dissertations
Over the last twenty years, the peer support segment of the behavioral health workforce has grown rapidly. However, few researchers have studied the effects on individuals from transitioning into the role. Likewise, there is limited research examining the professional development process of early career peer support specialists. To begin to fill these gaps in the literature, I conducted a qualitative research study examining workforce development experiences of peer support specialists in Kentucky. This dissertation reports on its findings and includes a policy paper with recommendations for improving policy and practice. Chapter one offers an introduction to the peer support workforce …
Biometric Features Modeling To Measure Students Engagement., Islam Mohamed Ahmed Mohamed Mahmoud Alkabbany
Biometric Features Modeling To Measure Students Engagement., Islam Mohamed Ahmed Mohamed Mahmoud Alkabbany
Electronic Theses and Dissertations
The ability to measure students’ engagement in an educational setting may improve student retention and academic success, revealing which students are disinterested, or which segments of a lesson are causing difficulties. This ability will facilitate timely intervention in both the learning and the teaching process in a variety of classroom settings. In this dissertation, an automatic students engagement measure is proposed through investigating three main engagement components of the engagement: the behavioural engagement, the emotional engagement and the cognitive engagement. The main goal of the proposed technology is to provide the instructors with a tool that could help them estimating …
Framing The Guard: A Content Analysis Of How The News Media Frames The National Guard During Times Of Crisis., Taylor L. Tolles
Framing The Guard: A Content Analysis Of How The News Media Frames The National Guard During Times Of Crisis., Taylor L. Tolles
Electronic Theses and Dissertations
A quantitative content analysis of 585 newspaper articles gathered from seven news sources that covered the National Guard’s response to COVID-19, BLM Protests, and the Capitol Riot were used to determine the prevalence of frames used to depict the Guard during times of crisis. By using the five frames found in media framing (Entman, 1991), the prevalence of frames found in newspaper media was compared to the prevalence of frames found to be used in times of crisis (Semetko & Valkenburg, 2000). The results showed that even though the Guard’s response in times of crisis is similarly framed as previous …
Motion And Emotion Estimation For Robotic Autism Intervention., Jacob M Berdichevsky
Motion And Emotion Estimation For Robotic Autism Intervention., Jacob M Berdichevsky
Electronic Theses and Dissertations
Robots have recently emerged as a novel approach to treating autism spectrum disorder (ASD). A robot can be programmed to interact with children with ASD in order to reinforce positive social skills in a non-threatening environment. In prior work, robots were employed in interaction sessions with ASD children, but their sensory and learning abilities were limited, while a human therapist was heavily involved in “puppeteering” the robot. The objective of this work is to create the next-generation autism robot that includes several new interactive and decision-making capabilities that are not found in prior technology. Two of the main features that …
Community Structure And Dynamics Of Benthic Macroinvertebrates In A Recreated Headwater Stream System On A Valley Fill In A Retrofitted Watershed Located In The Appalachian Coalfields Of Southeastern Kentucky (U.S.A.), Steven W. Bailey
Electronic Theses and Dissertations
The extraction of coal from steep-gradient surface mining sites such as in the Appalachian Coalfields of the U.S. produces excess debris that is often placed in adjacent valleys resulting in the creation of valley fills. Not only are headwater streams buried in the process, but watershed functions are either destroyed outright, or become fragmented and disconnected from adjacent ecosystems resulting in adverse effects to downstream biological communities. In this dissertation, the dynamics of stream macroinvertebrate community structure, composition, diversity, and biotic integrity are assessed at a “proof of concept” stream system recreated on a retrofitted valley fill. For comparison, two …
Histone Deacetylases In Alcohol Associated Liver Disease., Srineil Bodduluri
Histone Deacetylases In Alcohol Associated Liver Disease., Srineil Bodduluri
Electronic Theses and Dissertations
Alcohol abuse is endemic worldwide and there is no FDA approved treatment for Alcohol-Associated Liver Disease (ALD). Many scholars have posited that targeting Histone Deacetylases (HDAC) may be therapeutic in ALD intervention. In this study, the changes in hepatic gene expression and immune phenotyping of mice undergoing chronic plus binge alcohol exposure was examined. The characterization of relative mRNA levels for all 18 HDAC were performed. Results showed decreased expression of the genes HDAC 1,7,9,10,11 and Sirtuin enzymes (SIRT) 3,4,5,7. Other pathways related to lipid metabolism as well as systemic inflammation and hepatic injury also exhibited significant changes. These altered …
Multilateration Index., Chip Lynch
Multilateration Index., Chip Lynch
Electronic Theses and Dissertations
We present an alternative method for pre-processing and storing point data, particularly for Geospatial points, by storing multilateration distances to fixed points rather than coordinates such as Latitude and Longitude. We explore the use of this data to improve query performance for some distance related queries such as nearest neighbor and query-within-radius (i.e. “find all points in a set P within distance d of query point q”). Further, we discuss the problem of “Network Adequacy” common to medical and communications businesses, to analyze questions such as “are at least 90% of patients living within 50 miles of a covered emergency …
Micellar Nanocatalysis For Efficient Reactions., Uyen T Duong
Micellar Nanocatalysis For Efficient Reactions., Uyen T Duong
Electronic Theses and Dissertations
Water is considered a green, sustainable, and inexpensive solvent for organic synthesis. However, performing organic reactions in water is especially challenging due to the inherent insolubility of substrates and catalysts. Inspired from Nature, where chemistry happens in water, micellar catalysis has recently gained much attention, especially for applications in pharmaceutical industry. Aqueous micelles are generally formed by amphiphile`s self-aggregation, a particular class of molecules possessing both hydrophobic and hydrophilic components. The aqueous micelle contains a hydrophobic cavity, which allows the lipophilic substrates and catalyst to go inside micelles, allowing their much higher localized concentration that enhances the reaction rates and …
Linking Social Media, Medical Literature, And Clinical Notes Using Deep Learning., Mohsen Asghari
Linking Social Media, Medical Literature, And Clinical Notes Using Deep Learning., Mohsen Asghari
Electronic Theses and Dissertations
Researchers analyze data, information, and knowledge through many sources, formats, and methods. The dominant data format includes text and images. In the healthcare industry, professionals generate a large quantity of unstructured data. The complexity of this data and the lack of computational power causes delays in analysis. However, with emerging deep learning algorithms and access to computational powers such as graphics processing unit (GPU) and tensor processing units (TPUs), processing text and images is becoming more accessible. Deep learning algorithms achieve remarkable results in natural language processing (NLP) and computer vision. In this study, we focus on NLP in the …
Git (Gender-Informed Trauma) In Black N Blue Boys / Broken Men: How Concepts Of Gender Restrict The Black Male Actor’S Creative Process And The Methods He Can Use For Creative Freedom., Tyler Tate
Electronic Theses and Dissertations
This study examines how the black male actor’s creative process can be affected by historical and cultural constructions of masculinity connected to race, sexuality, and physical movement. My research on black men’s experience with gender identity finds that social and cultural forces lead black men to reproduce behaviors that mirror a prescribed masculine ideal through physical movement. This prescribed masculine behavior is typically coded in terms of stiffness or lack of expression. This study explores how self-imposed restrictions reiterated by social standards of masculine behavior limit the creative freedom in the black male actor’s creative process. Specifically, black male actors’ …
Micelles And Lipid Nanoparticles: Catalysis And Biomedical Application., Faisal Ibrahim
Micelles And Lipid Nanoparticles: Catalysis And Biomedical Application., Faisal Ibrahim
Electronic Theses and Dissertations
RNA-based therapeutics is a rapidly expanding field due to its enormous potential for treatment of diseases through knockdown of genes or expression of therapeutic proteins. However, due to the overall negative-charge of an RNA molecule, RNA-based therapeutics must rely on delivery systems to overcome the various biological barriers for ultimate release of an RNA payload into the cytosol. Over the past three decades, the development of lipid-based RNA delivery systems, especially lipid nanoparticles (LNPs), have been comprehensively studied due to their unique properties. LNPs represent the most widely used delivery systems for RNA-based therapeutics, as evidenced by the clinical approvals …
The Food Truck Problem, Supply Chains And Extensions Of The Newsvendor Problem, Dennis Quayesam
The Food Truck Problem, Supply Chains And Extensions Of The Newsvendor Problem, Dennis Quayesam
Electronic Theses and Dissertations
Inventory control is important to ensuring sufficient quantities of items are available tomeet demands of customers. The Newsvendor problem is a model used in Operations Research to determine optimal inventory levels for fulfilling future demands. Our study extends the newsvendor problem to a food truck problem. We used simulation to show that the food truck does not reduce to a newsvendor problem if demand depends on exogenous factors such temperature, time etc. We formulate the food truck problem as a multi-product multi-period linear program and found the dual for a single item. We use Discrete Event Simulation to solve the …
Trends In Hysterectomy In Hospital And Ambulatory Settings In Kentucky 2017-2020., Felicia A. Pugh
Trends In Hysterectomy In Hospital And Ambulatory Settings In Kentucky 2017-2020., Felicia A. Pugh
Electronic Theses and Dissertations
Hysterectomy is the most common treatment for benign uterine conditions in the United States. Data suggest that one in nine women will have the procedure in their lifetime (1). Previous studies indicate that abdominal hysterectomy rates for non-malignancies are declining as alternative methods are increasing for decades; however, those trends do not apply for all women in the country (2-5). In this cross-sectional study, hysterectomy procedures completed between 2017-2020 are described in Kentucky Cabinet for Health and Family Services data. Multivariable logistic regression is used to assess the odds of abdominal hysterectomy for benign indications in Kentucky. Conclusion: Rates of …
Approaching Trans Debates As Fascistic Sites Of Engagement., Sarah Jump
Approaching Trans Debates As Fascistic Sites Of Engagement., Sarah Jump
Electronic Theses and Dissertations
For the past decade, trans rights issues have been a legal topic of discussion and are still discussed publicly in 2021. This thesis researched how arguments surrounding anti-trans issues were successful in the United States. The arguments surrounding these issues are important to study to see how they pass within society and if traditional rules of argumentation are changing. This thesis proposes that traditional dialectical argument is no longer occurring and has taken a post-dialectical turn. The purpose of this thesis is to describe the kinds of arguments used in these issues and build the case that they are evidence …
A Social Learning Approach To The Examination Of The Temporal Directionality Between Parenting Behavior And Early Adolescents' Affect., Shelby M. Burton
A Social Learning Approach To The Examination Of The Temporal Directionality Between Parenting Behavior And Early Adolescents' Affect., Shelby M. Burton
Electronic Theses and Dissertations
This study contributes to current literature by being the first to longitudinally examine the relation between early adolescents’ negative and positive affect and specific parenting behaviors. The five parenting behaviors examined in the current study are rooted within the social learning theory constructs of effective discipline (i.e., corporal punishment, inconsistent discipline), positive involvement (i.e., parental involvement), monitoring (i.e., poor monitoring and supervision), and social skills encouragement (i.e., positive parenting). Two research questions were addressed: (1) how are parenting behaviors at baseline associated with early adolescent-reported NA and PA at a later timepoint, and (2) how are early adolescents’ NA and …
Lightweight Mutual Authentication And Privacy Preservation Schemes For Iot Systems., Samah Mansour
Lightweight Mutual Authentication And Privacy Preservation Schemes For Iot Systems., Samah Mansour
Electronic Theses and Dissertations
Internet of Things (IoT) presents a holistic and transformative approach for providing services in different domains. IoT creates an atmosphere of interaction between humans and the surrounding physical world through various technologies such as sensors, actuators, and the cloud. Theoretically, when everything is connected, everything is at risk. The rapid growth of IoT with the heterogeneous devices that are connected to the Internet generates new challenges in protecting and preserving user’s privacy and ensuring the security of our lives. IoT systems face considerable challenges in deploying robust authentication protocols because some of the IoT devices are resource-constrained with limited computation …
"When The Voices Of Children Are Heard": Evaluating The Biological Effects Of Socioeconomic Status On Children In Postmedieval London., Ashley R. Ezzo
"When The Voices Of Children Are Heard": Evaluating The Biological Effects Of Socioeconomic Status On Children In Postmedieval London., Ashley R. Ezzo
Electronic Theses and Dissertations
As the most vulnerable members of society, children (and their treatment) may reveal important sociocultural and socioeconomic praxes throughout human history. During the Postmedieval period, children, especially low socioeconomic status (SES) individuals, participated in the workforce. By examining the demographic distributions and paleopathological profiles of juvenile skeletal remains from high SES (St. Bride’s Crypt and Chelsea Old Church) and low SES (St. Bride’s Lower and Crossbones) Postmedieval (1700-1850 CE) London cemeteries, we can better understand how SES impacted the biological health and mortality of children. While results indicated higher mortality risk associated with low SES circumstances, most differences in pathological …
Development Of 3d-Bioprinted Scaffolds For Oral Probiotic Application., Jhanvi Patel
Development Of 3d-Bioprinted Scaffolds For Oral Probiotic Application., Jhanvi Patel
Electronic Theses and Dissertations
Background: Porphyromonas gingivalis adheres to and invades gingival epithelial cells, resulting in decreased cell viability. Previous studies have indicated that probiotics are effective against dental pathogens; however, few approaches provide sustained-delivery of active agents in the oral cavity. Hypothesis: Probiotics will limit P. gingivalis effects on Telomerase Immortalized Gingival Keratinocyte (TIGK) cells and 3D-printed scaffolds will prolong probiotic release. Methods: Lactobacillus acidophilus, Lactobacillus reuteri, and Bifidobacterium bifidum were assessed with adhesion and antibiotic protection assays to limit P. gingivalis effects on TIGKs. Scaffolds were printed with a select probiotic and evaluated for release kinetics. Results: Free L.a., …
Witness And Testimony: The Role Of Race And Community In Forming Black Aesthetics., Cathy Smith Shannon
Witness And Testimony: The Role Of Race And Community In Forming Black Aesthetics., Cathy Smith Shannon
Electronic Theses and Dissertations
This thesis is a visual examination of the relationship of community to output of black artists, inspired by the Social Justice movement of 2020. It was important to note the impact on artistic output of community and environment that influenced each artist. This thesis looks at the work of two artists that grew up in the 1930s and launched their This thesis looks at the work of two artists that grew up in the 1930s and launched their Rights era of the 1960s began their artistic careers during the 1980s; and two artist that were born during the 1960s Civil …
Synthesis Of Flagellin 22 As A Probe For Plant Signaling And Molecular Trafficking Towards Improved Crops, Edward Offei
Synthesis Of Flagellin 22 As A Probe For Plant Signaling And Molecular Trafficking Towards Improved Crops, Edward Offei
Electronic Theses and Dissertations
Plant signaling involves the transport of information within and between plant cells from receptors to effectors. Plants are affected by biotic and abiotic stress conditions like insect attack and extreme temperatures, respectively, which cause disease, the induction of senescence and the reduction of crop yield. To improve plant traits for feed, fiber, and energy applications, it is critical to understand the short- and long-range signaling mechanisms plants use to control growth, biomass composition, senescence and responses to environmental stresses. It is known that many plant signaling molecules have profound effects on plants, through mechanisms that remain largely obscure. A key …