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Development Of A Microfluidic Viscoelastic Hemostatic Assay For Real-Timeviscosity Measurements Of Blood, Shay Kent
Electronic Theses and Dissertations
Blood coagulation disorders are malfunctions in the body’s ability to control blood clotting. It can result in either insufficient clotting causing an increased risk of bleeding or excessive clotting obstructing blood flow. The rapid and accurate diagnosis of coagulopathies is an important, unmet need in the clinical setting. Rapidly identifying the source of bleeding, either acquired or inherited, is critical to reduce the risk of major blood loss and deliver personalized hemostatic therapies. Viscoelastic hemostatic assays, or VHAs, deliver an effective solution to the diagnosis of coagulopathies by evaluating global hemostatic function using whole blood rather than plasma. VHAs are …
The Cultural Worldview Of Women Trafficked For Sex In The U.S: An Ethnonursing Study Exploring Health And Well-Being Beliefs, Values And Practices From An Emic Perspective, Christine Lepianka
The Cultural Worldview Of Women Trafficked For Sex In The U.S: An Ethnonursing Study Exploring Health And Well-Being Beliefs, Values And Practices From An Emic Perspective, Christine Lepianka
Electronic Theses and Dissertations
Introduction: Women who have been trafficked for sex in the United State report that the health care they receive is not consistently helpful or tailored to their unique needs. The purpose and domain of inquiry (DOI) for this study was to discover, understand, and describe health and well-being beliefs, values, and practices of U.S. born women who have been trafficked for sex in the United States, in order to provide culturally congruent nursing care. Method: Leininger’s Culture Care Theory (CCT), ethnonursing research method (ERM), and enablers guided the researcher as she explored the DOI. Interviews were conducted with 11 key …
The Role Of Mek1/2 And Mek5 In Melatonin-Mediated Actions On Osteoblasts And Osteoclasts Differentiation, Bone Formation, Bone Microarchitecture, And Bone Biomechanics, Fahima Akter Munmun
The Role Of Mek1/2 And Mek5 In Melatonin-Mediated Actions On Osteoblasts And Osteoclasts Differentiation, Bone Formation, Bone Microarchitecture, And Bone Biomechanics, Fahima Akter Munmun
Electronic Theses and Dissertations
Melatonin, the main endogenous hormone to entrain the circadian system, is not limited to its role in regulating the sleep-wake cycle; rather, it affects a wide variety of systems involving antioxidant, anti-inflammation, blood pressure regulation, seasonal reproduction, ovarian physiology, and immune function. Driven by the diversity of its action, melatonin for a long time has also been studied in the field of bone and mineral research both clinically and pre-clinically. Exogenous administration of melatonin in clinical trials in perimenopausal women (MOPS; NCT01152580); or postmenopausal women with osteopenia (MelaOST; NCT01690000 and MOTS; NCT01870115) confirmed improvement of bone mineral density (BMD) (MelaOST; …
Towards A "Universal Chemical Biology Toolbox" For Tackling Human Diseases, Christopher Swank
Towards A "Universal Chemical Biology Toolbox" For Tackling Human Diseases, Christopher Swank
Electronic Theses and Dissertations
A lack of new drug targets and drug mechanisms, coupled with drug-pipeline attrition, represent significant problems in oncology drug discovery. Towards addressing this challenge, “fully-functionalized small-molecule probes” (FFSMPs) have been established, which are compounds that can be immediately used as “bait” to capture their protein targets under the same assay conditions used for oncology-based phenotypic screening. Specifically, each FFSMP library member contains one or more structural-diversity elements to promote interactions of the probe with different protein targets in living cells, an electrophile or photoreactive functional group for covalent attachment of the probe to interacting proteins via affinity or photoaffinity labeling, …
Technological Change And The Practice Of Healthcare Communication: Implications For Patient-Centered Care, From A Communication Ethics Perspective, Emmalee Torisk
Electronic Theses and Dissertations
Written in a historical moment marked in many ways by the COVID-19 pandemic and the changes it has wrought, including the increased availability and use of telehealth services, this project attempts to consider the implications of the continued integration of technology into health care, centering on the following essential question: How do technological changes affect the contemporary practice of healthcare communication, particularly that which occurs between the patient—the consumer of health care—and their provider? This dissertation thus considers the ways in which such linkages of technology and health care seem to fit into a larger shift within health care …
Developing A Teacher Professional Development Activity With Social Learning Theory To Address Educators’ Attitudes, Knowledge, And Skills In Working With Lgbtqia+ Youth, Jacob Wadsworth
Electronic Theses and Dissertations
It is well documented that children who identify as a sexual minority or as gender-non-conforming are at an increased likelihood to experience adverse events and risk factors that can make it difficult to function in the community, home, and school environments. Lesbian, gay, bisexual, transgender, and questioning, intersex, or asexual (LGBTQIA+) youth report high levels of bullying and victimization with little or no effective intervention from teachers in schools. Research shows that not only are teachers ill-prepared to effectively intervene, but also they engage in homophobic behavior that contribute to a negative school climate. Previous literature shows that there is …
Inviting Friendship: A New Approach To Nonprofit Communication, Stacia Glenn Wetherington
Inviting Friendship: A New Approach To Nonprofit Communication, Stacia Glenn Wetherington
Electronic Theses and Dissertations
Beginning with Greeks’ concept of virtuous friendship philanthropy has been part of society. Metaphors of civitas, caritas and social responsibility dominated man’s understanding of charity until the explosion of neoliberal thought in the 1980s. The Band Aid movement in response to the Ethiopian famine permanently changed the way we view philanthropy. This movement created an environment of extreme commodification of charity which has created a highly competitive nonprofit sector and a loss of the collective spirit upon which it was founded. This competitive atmosphere has led nonprofits to chase dollars at the expense of their missions while also relying heavily …
Interdependence With Our Most Forgetful Elders: Alzheimer's In The Anthropocene, Christine Heller
Interdependence With Our Most Forgetful Elders: Alzheimer's In The Anthropocene, Christine Heller
Electronic Theses and Dissertations
This dissertation uses autoethnography and critical psychological and philosophical theories to explore what people with Alzheimer’s disease teach us about being, forgetting, and dying in the Anthropocene. The author collected personal memory data from her lived experience of being with her mother while she had Alzheimer’s disease, and organized these memories into a series of vignettes. Each vignette was analyzed with critical psychological and philosophical theories to illuminate intersubjective themes of denial, things, ancestors, place, dying, and time. These themes connected the personal to the epochal and articulated the wisdom that our most forgetful elders can share in the Anthropocene, …
Investigation Of Ongoing Unconventional Gas Extraction And Underground Gas Storage In Pennsylvania: Regulations And Water Quality, Cassandra Ziegler
Investigation Of Ongoing Unconventional Gas Extraction And Underground Gas Storage In Pennsylvania: Regulations And Water Quality, Cassandra Ziegler
Electronic Theses and Dissertations
The extraction of unconventional shale gas and its underground gas storage have the potential to impact surface and groundwater water quality. In New Sewickley Township, Beaver County, Pennsylvania, 54 unconventional gas wells were drilled between 2013 and 2019. Groundwater samples from 33 water wells and surface water from Brush Creek (18 samples) were collected and analyzed for anions, cations, and light hydrocarbons. Results showed that at least 8 wells had indicators of brine contamination, and the surface waters of mine drainage. The Steckman Ridge natural gas storage field in Clearville, Bedford County, PA has 13 active storage wells. Samples were …
New Texas Elementary Teachers' Perspective Of Needed Supports For Career Retention: A Qualitative Study, Patrick Guy
New Texas Elementary Teachers' Perspective Of Needed Supports For Career Retention: A Qualitative Study, Patrick Guy
Electronic Theses and Dissertations
The study specifically investigated new elementary teachers' perceptions of the support they need during the first five years of their teaching experiences to influence their decision to remain both at their current teaching assignment and in the profession. The literature detailed specific elements of leadership within the realm of support that lends to teacher retention. A qualitative methodology was employed for to collect in-depth interview data from three Texas elementary entry teachers. The original intent was for five participants, however due to the COVID-19 pandemic, only three participants took part in this study. The researcher identified themes that emerged from …
Exploring The Impact Of The Achievement Gap On Shame And Resilience In African American College Students, Brittany R. Thomas
Exploring The Impact Of The Achievement Gap On Shame And Resilience In African American College Students, Brittany R. Thomas
Electronic Theses and Dissertations
The achievement gap refers to the stark difference that occurs between racial or gender groups, as one group performs significantly higher than the other. An achievement gap has the propensity to produce psychological distress, as well as buffering techniques that are necessary for survival and success. Growing research shows that African American college students experience unique levels of trauma, shame, hardship, macro, and micro-aggressions, suggesting that these students learn to self-preserve as early as 10 years old. This study used a Pearson correlation, Independent T-Test, and a Moderated Multiple Regression to explore the impact of the achievement gap on shame …
Deception Of Resistance And The Effects On Muscular Fitness And Perceived Exertion, Tyler Mchenry
Deception Of Resistance And The Effects On Muscular Fitness And Perceived Exertion, Tyler Mchenry
Electronic Theses and Dissertations
Resistance training has been a popular tactic that individuals have used to increase muscular fitness for decades. Muscular fitness includes muscular endurance, strength, and power. However, limitations such as self-efficacy and the Central Governor Theory may influence individual maximal performance ability. One training tactic that has been rarely researched is the deception of resistance during exercise, which is assumed to increase performances in all aspects of muscular fitness and improvements in perceived effort. Inconsistent results have been concluded from previous studies that have examined the same topic. Therefore, the purpose of this study was to investigate the effect of resistance …
Development Of Standard Operating Procedure With Modified Method To Quantify Benzene And Other Volatile Organic Compounds In Air Samples Using Gas Chromatography, Heather Hall
Electronic Theses and Dissertations
Stephen F. Austin State University (SFASU) Department of Environmental Science has recently invested in a gas chromatograph which can be used to analyze air samples for volatile organic compounds (VOCs) such as benzene, toluene, ethylbenzene, and xylenes (BTEX). The goal of this project was to develop a standard operating procedure (SOP) and modify the current method for the detection of VOCs associated with oil and gas drilling activity to accommodate the equipment and capabilities of SFASU Environmental Assessment Lab. This study aims to provide the framework for future research in air quality monitoring in the Eagle Ford Shale area. An …
An Enhanced Framework To Compute Road User Costs Associated With Construction Zones, Jeremiah Adebiyi
An Enhanced Framework To Compute Road User Costs Associated With Construction Zones, Jeremiah Adebiyi
Electronic Theses and Dissertations
The monetary quantification of inconveniences caused to the road users by ongoing construction activities is known as the Road Users Costs (RUCs). While the importance of RUCs is widely known, some highway agencies lack an appropriate methodology to compute RUCs. Thus, there is a need to develop a framework to compute RUCs that can be adopted quickly by highway agencies. This study reviewed existing literature and conducted a nationwide survey to identify and summarize the current practices of computing RUCs. It developed an enhanced framework and tool to compute RUCs that balances the effort required to calculate RUCs and the …
An Investigation Of The Impact Of Covid-19 Infection Control On Visual Art Installations In Hospitals With Pediatric Patients, Shannon Kimich
An Investigation Of The Impact Of Covid-19 Infection Control On Visual Art Installations In Hospitals With Pediatric Patients, Shannon Kimich
Electronic Theses and Dissertations
This study investigated the impact of COVID-19 infection control on visual artwork in pediatric hospitals and hospitals caring for pediatric patients. The study involved five hospitals in three southern America states and addressed visual artwork and art installations. The researcher administered an internet-based survey to participants in job functions related to hospital administration, environmental services, and project management across the facilities and received participation from 18 respondents. Additionally, telephone interviews were conducted with three participants with the job titles project manager/analyst, child-life specialist, and environmental services director. Survey questions were designed to examine visual art programs in selected children’s hospitals …
An Evaluation Of Cancer Nurse Providers’ Implementation Of The 2018 Commission On Cancer Survivorship Care Plan Requirement, Angelia Natascha Drake
An Evaluation Of Cancer Nurse Providers’ Implementation Of The 2018 Commission On Cancer Survivorship Care Plan Requirement, Angelia Natascha Drake
Electronic Theses and Dissertations
There are apparent problems and fragmentation in the health care delivery system across all specialties, specifically oncology. Oncology is an area within the health care system that has an exponential growth of patients. The incidences of newly diagnosed cancer patients are increasing annually, and the improvements in cancer treatments allow patients to live beyond cancer, resulting in an increased volume of survivors annually as well. These increases place an incredible demand on our health care system, including, but not limited to, primary care physicians and specialists such as medical oncologists. With these increases, there is still an evident gap within …
Is Being Respectable Enough?: A Critical Investigation Of Code-Switching And The Lived Experiences Of Black Leaders Who Work At Nonprofits In Bridgertown, Ramona Crawford
Is Being Respectable Enough?: A Critical Investigation Of Code-Switching And The Lived Experiences Of Black Leaders Who Work At Nonprofits In Bridgertown, Ramona Crawford
Electronic Theses and Dissertations
The current literature on Black nonprofit leaders is scarce, causing little to be known about the experiences that they have encountered when navigating their roles and responsibilities. Even less literature is available on these Black leaders and their usage of code-switching strategies when attempting to navigate those same nonprofits. Based on themes uncovered during the literature review this study employs an in-depth narrative inquiry qualitative methodology. While using theories such as critical race theory (Delgado & Stefancic, 200; Ladson-Billings,1998), the politics of respectability (Higginbotham, 1993) and the theory of capital (Bourdieu, 1985; 1996) the researcher examines the leadership experiences of …
Economic And Sociological Factors Associate With First-Year African American Students' Enrollment In Historically Black Colleges And Universities., Vickie Gale Bridgeman
Economic And Sociological Factors Associate With First-Year African American Students' Enrollment In Historically Black Colleges And Universities., Vickie Gale Bridgeman
Electronic Theses and Dissertations
Despite the long struggle to gain access, African Americans always have valued education. Historically Black colleges and universities (HBCUs) were established to educate Blacks. The racial integration of predominately White institutions (non-HBCUs) in the 1960s led to decreased enrollments in HBCUs and challenged their relevance. The purpose of this study is to discover what factors influence African American students to choose an HBCU today. Quantitative, secondary survey data methods were used to conduct the study. African American students at HBCUs and non-HBCUs participated in the survey. Consistent with generally accepted approaches in analyzing student college choice, this study utilized logistic …
Predictive Modeling Of Clinical Outcomes For Hospitalized Covid-19 Patients Utilizing Cytof And Clinical Data., Onajia Stubblefield
Predictive Modeling Of Clinical Outcomes For Hospitalized Covid-19 Patients Utilizing Cytof And Clinical Data., Onajia Stubblefield
Electronic Theses and Dissertations
In December 2019, an outbreak of a novel coronavirus initiated a global pandemic. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a virus that causes the disease coronavirus disease 2019 (COVID-19). Symptoms of infection with COVID-19 vary widely between individuals. While some infected individuals are asymptomatic, others need more extensive care and require hospitalization. Indeed, the COVID-19 pandemic was characterized by a shortage of hospital beds which presented additional complications in providing adequate care for patients. In this study, we used a combination of T cell population data collected from mass cytometry analysis and clinical markers to form a predictive …
Manipulating Mindful Breathing Versus Mindful Eating: Examining The Effect Of Specific Mindfulness Mechanisms On Food Intake And Eating Disorder Symptoms., Irina Alexandrovna Vanzhula
Manipulating Mindful Breathing Versus Mindful Eating: Examining The Effect Of Specific Mindfulness Mechanisms On Food Intake And Eating Disorder Symptoms., Irina Alexandrovna Vanzhula
Electronic Theses and Dissertations
Background. Understanding which specific mindfulness practices contribute to improvements in ED symptoms, as well as the mechanisms of action by which this change occurs, may help improve MBTs for EDs. The current study aims to compare the effects of various brief mindfulness exercises on state ED symptoms and food intake and to test whether a reduction in state rumination and state difficulties in emotion dysregulation and an increase in awareness of hunger, fullness, and satiety cues mediate these effects. Methods. Two hundred and two undergraduate females participated in the experiment. Participants were randomized to listen to one of the four …
Investigating The Effects Of Perfluorooctanoic Sulfonate (Pfos) And Ethanol On Fatty Liver Disease Using A Modified Niaaa Model., Tyler Charles Gripshover
Investigating The Effects Of Perfluorooctanoic Sulfonate (Pfos) And Ethanol On Fatty Liver Disease Using A Modified Niaaa Model., Tyler Charles Gripshover
Electronic Theses and Dissertations
Perfluoroalkyl Substances (PFAS) are a family of man-made, surfactant-like compounds that are a major environmental contaminant. A multitude of studies have indicated that PFAS are able to induce fatty liver disease and modulate lipid metabolism. However, the distinct mechanism of PFAS influence on the liver and metabolism disruption remains to be elucidated. On the other hand, it is well documented that alcohol consumption has various adverse health impacts including fatty liver disease and subsequent progression to more adverse liver states. To date, there are no published studies on whether PFAS and alcohol can jointly exacerbate fatty liver progression or interact …
Decreased Kidney Mitochondrial Content And Pgc-1Α Following Repeated Low-Dose Cisplatin-Induced Kidney Injury., Andrew Joseph Orwick
Decreased Kidney Mitochondrial Content And Pgc-1Α Following Repeated Low-Dose Cisplatin-Induced Kidney Injury., Andrew Joseph Orwick
Electronic Theses and Dissertations
Cisplatin is highly effective and one of the most commonly used chemotherapeutic agents in the treatment of a number of different solid organ tumors. Unfortunately, the dose-limiting nephrotoxicity occurs in up to 30% of patients, which requires alterations to treatment regimens that are often less effective. The kidney’s function is to provide fluid homeostasis, and this is an energy-intensive process. Proper renal function is dependent on functional mitochondria. PGC-1α regulates mitochondrial number, respiratory capacity, and mitochondrial proteins in proximal tubule cells. We delivered low-dose cisplatin to mice via intraperitoneal injections once a week for 4 weeks. The mice were then …
General Strain Theory And Violent Behavior In A Military Sample., Leslie A. Greenwell
General Strain Theory And Violent Behavior In A Military Sample., Leslie A. Greenwell
Electronic Theses and Dissertations
The present study examines violent behavior in a military sample through an examination of General Strain Theory (GST). The overall sample (n = 21,449) is made up of active-duty, national guard, and reserve U.S. Army soldiers surveyed from 2011 to 2013 for the All Army Study (AAS) component of the Study to Assess Risk and Resilience in Servicemembers (STARRS). The present study is a secondary analysis of the STARRS’ data. Overall, the results of the present study produce empirical support for GST. Binomial logistic regression analyses show that all measures of strain (e.g., deployment, health, and life spheres strain), …
Oligodendrocyte Responses After Spinal Cord Injury., George Zach Wei
Oligodendrocyte Responses After Spinal Cord Injury., George Zach Wei
Electronic Theses and Dissertations
Recent studies demonstrate that neuroprotection strategies targeting the proteostasis network and components of its effector signaling pathways improve cell survival and motor recovery outcomes in several models of neuronal injury and degeneration. However, the individual contributions of these signaling pathways to the pathogenesis of spinal cord injury (SCI), white matter damage, and motor recovery have not yet been determined. Here, I explored the role of the HIF prolyl hydroxylase domain proteins (PHD/EGLN), effectors that can modulate stress responses activated by the proteostasis network, on motor function recovery after SCI. Furthermore, I identified previously unknown candidate mechanisms in an unbiased manner …
Development And Validation Of Biosafety Climate Scale And Survey-Based Analyses Of Safety Perceptions In Biological Research And Teaching Laboratories At Public Universities In The Usa., Sivarchana Mareedu
Electronic Theses and Dissertations
Biosafety plays a key role in ensuring safety of researchers’ as well as the public from unintentional exposures to infectious agents. However, the occurrence of lab acquired infections, exposures, and safety lapses in biological laboratories underscores challenges in biosafety program management. The raise in emerging and reemerging infectious diseases and the ongoing COVID-19 pandemic reiterates the need for biosafety and research community to work together. Literature recommends the application of safety climate in measuring safety culture. The goal of this dissertation is to quantify biosafety climate and examine associated factors to understand the gaps between research and biosafety professionals in …
The Impact Of Criminal Justice Involvement: Examining Experiences In A Housing First Program., Amanda N. Denton
The Impact Of Criminal Justice Involvement: Examining Experiences In A Housing First Program., Amanda N. Denton
Electronic Theses and Dissertations
Individuals who come into contact with the criminal justice system are more likely to experience housing instability and homelessness, which, in turn, increases the likelihood of subsequent criminal justice involvement. Due to a lack of federal funding, as well as disjointed and inconsistent policies regarding eligibility criteria, people with criminal records are unlikely to receive federal rental assistance. While the exclusion of people with criminal histories is presented as necessary to protect communities and residents from crime, improving access to stable housing may reduce recidivism, incarceration rates, and correctional costs and increase public safety. The present study examined the differences …
Rapid Annealing Of Perovskite Solar Cell Thin Film Materials Through Intense Pulse Light., Amir Hossein Ghahremani
Rapid Annealing Of Perovskite Solar Cell Thin Film Materials Through Intense Pulse Light., Amir Hossein Ghahremani
Electronic Theses and Dissertations
Perovskite solar cells (PSCs) have garnered a great attention due to their rapid efficiency improvement using cheap and solution processable materials that can be adapted for scalable high-speed automated manufacturing. Thin film perovskite photovoltaics (PVs) are typically fabricated in an inert environment, such as nitrogen glovebox, through a set of deposition and annealing steps, each playing a significant role on the power conversion efficiency (PCE), reproducibility, and stability of devices. However, atmospheric processing of PSCs would achieve lucrative commercialization. Therefore, it is necessary to utilize materials and methods that enable successful fabrication of efficient PSCs in the ambient environment. The …
Concurrent Reporting Of Adverse Childhood Experiences Among Perspectives Of Adolescents And Caregivers., Katie J. Berghuis
Concurrent Reporting Of Adverse Childhood Experiences Among Perspectives Of Adolescents And Caregivers., Katie J. Berghuis
Electronic Theses and Dissertations
The consequences of Adverse Childhood Experience (ACE) events in youth have predominantly been studied through retrospective studies that assess adults’ first 18 years of life or caregiver report of ACEs in youth. Reliance on only caregiver report to discern ACEs is a limitation amongst prior studies as research has found that caregivers tend to underestimate ACEs among their children, and there is even a greater discrepancy of reporting between caregivers and youth 12 years and older. Therefore, this study investigated concurrent reporting of self-report ACE scores in adolescents – defined in this study as 12 to 20 years old – …
A Qualitative Study Of 129 Police Lethal Force Incidents In 2016 Examining Participant Behavior Relating To Mental Illness That Contributes To The Use Of Lethal Force., Edward H. Byers
Electronic Theses and Dissertations
This multi-case, exploratory research study examined videos and related news media articles of lethal police shootings and found commonalities and possible contributing factors. Videos and informational articles posted on news media websites in the public domain were used in a qualitative content analysis to identify common elements in police lethal force incidents. The results of this study revealed contributing behaviors by the participants related to mental illness that contribute to lethal force. The decision to use lethal force by a police officer is framed using four analytical themes.
Metabolic-Epigenetic Regulation Of Macrophage Polarization., Jordan T. Noe
Metabolic-Epigenetic Regulation Of Macrophage Polarization., Jordan T. Noe
Electronic Theses and Dissertations
Tumor-associated macrophages polarized to an M2 phenotype (M2-TAMs) promote neo-angiogenesis, tumor-stromal matrix remodeling, and immuno-evasion, which, collectively, contribute to immunotherapeutic resistance and reduced cancer patient survival. Highly glycolytic “Warburg” cancer cells produce lactate that independently drives naïve M0→immunosuppressive M2 (M0→M2) macrophage polarization, but the mechanisms have not been fully elucidated. The atypical cytokine macrophage migration inhibitory factor (MIF) is a fundamental underlying requirement for immunosuppressive M2 macrophage polarization. Still, it is unknown whether a molecular link exists between lactate-supported and MIF-dependent M2 macrophage polarization. Using a combination of gene expression assays, chromatin immunoprecipitation, and metabolomic analyses, we identified that M2 …