Digital Commons Network^™

False Memories Are Impacted By Semantic Pairing Of Drm Lists., Ryan Coleman

Electronic Theses and Dissertations

In the DRM paradigm, experience of semantically related words leads to false memories of related words called critical lures. These false memories serve as evidence that the relationship between items in a DRM list contribute to an overall gist or central concept for the experience. The present studies aim to investigate whether the higher-order semantic relationship that exists between different DRM lists can also influence recognition memory. Study 1 compared memory confidence ratings for list items and critical lures to two metrics: “Temporal Contiguity”, how closely in time lists appeared to each other at encoding, and “Semantic Distance”, the semantic …

Statistical Inference On Lung Cancer Screening Using The National Lung Screening Trial Data., Farhin Rahman

Electronic Theses and Dissertations

This dissertation consists of three research projects on cancer screening probability modeling. In these projects, the three key modeling parameters (sensitivity, sojourn time, transition density) for cancer screening were estimated, along with the long-term outcomes (including overdiagnosis as one outcome), the optimal screening time/age, the lead time distribution, and the probability of overdiagnosis at the future screening time were simulated to provide a statistical perspective on the effectiveness of cancer screening programs. In the first part of this dissertation, a statistical inference was conducted for male and female smokers using the National Lung Screening Trial (NLST) chest X-ray data. A …

Why Are Measures Of Depression Imperfectly Correlated? An Empirical Investigation., Eric Joseph Smith

Electronic Theses and Dissertations

Depression remains one of the most prevalent and impactful mental health disorders worldwide. A large number of measures of depressive symptoms are currently available, all designed to assess the same underlying construct. However, the measures tend not to correlate highly with one another. Measurement error cannot fully account for this observation, suggesting that clinical heterogeneity – that is, differences in symptom coverage across measures – might contribute to the lower-than-expected correlation between measures. We conducted two concurrent studies to examine this hypothesis. In Study 1, we developed a coding scheme to categorize items into one of 10 symptom categories. We …

Where Are All The Women?: Using Role Congruity Theory To Explore The Experiences Of Female Interscholastic Athletic Directors., Nicholas Swim

Electronic Theses and Dissertations

Leadership in sport organizations continues to be male dominated, even as multiple scholars have argued and proven the importance of women holding sport leadership positions (Burton & Leberman, 2017; Darvin & Lubke, 2021; Schull, 2017). The lack of women attaining these positions leads to fewer opportunities for role modeling and mentoring experiences for female athletes. As Burden et al. (2010) argue, interscholastic athletic directors are important as they usually represent the first interactions for young athletes with people in sport leadership positions. Researchers have investigated this phenomenon at the intercollegiate level (Bower & Hums, 2013; Darvin & Lubke, 2021; Taylor …

Novel Breath Collection Techniques For Detection Of Covid-19., James Morris

Electronic Theses and Dissertations

Volatile Organic Compounds (VOC) generated endogenously in the human body can be used to detect diseases that induce oxidative stress and inflammation. Breath analysis has been used for the detection of diseases such as COPD, Depression, Lung Cancer and most recently COVID-19. Methods such as Exhaled Breath Condensate (EBC), Sorbent Tubes, Solid Phase Microextraction (SPME), and silicon microreactors have shown considerable capability in extracting and concentrating trace VOC’s present in human breath. Silicon microreactors functionalized with capture agents to derivatize carbonyl compounds are effective but the overall maximum flow rate of breath sample possible during analysis is low, making direct …

Clinical And Environmental Factors Affecting The Survival Outcomes Among Stage 1a Tn0m0 First Primary Non-Small Cell Lung Carcinoma Patients In The United States., Naiya Patel

Electronic Theses and Dissertations

Background: Lung cancer is the second leading cause of death in the United States (U.S.). The most prevalent histological type of lung cancer is Non-Small Cell Lung Cancer (NSCLC), which has an overall five years survival of 5% if left untreated. Therefore, early treatment of NSCLC is vital to improve overall survival (OS) outcomes. Several factors affect survival outcomes, which can be categorized as modifiable or non-modifiable. The difference in timely receipt of guideline-concordant treatment affects the survival outcomes of patients with stage 1A NSCLC. This dissertation explored factors that affect treatment and survival outcomes among stage 1A NSCLC patients …

Statistical Methods For Assessing Treatment Effects On Ordinal Outcomes And Selecting Optimal Treatment On Survival Outcomes Using Observational Data., Huirong Hu

Electronic Theses and Dissertations

This dissertation consists of two projects investigating statistical methods in causal inference and personalized medication using observational data. In the first project, we propose a parametric marginal structural ordinal logistic regression model (MS-OLRM) to assess treatment effects on ordinal outcomes. Average treatment effect (ATE) is used to measure the difference of the mean outcomes if all patients would have been treated compared with the outcomes if they would not have been treated. Many statistical methods have been developed to estimate ATE when the outcome is continuous or binary. The methodology on assessing treatment effect for an ordinal outcome is less …

The Relationships Between State-Level Economic Policies, Child Maltreatment, And Suicidal Behavior And Mortality., Yana B. Feygin

Electronic Theses and Dissertations

Suicide has proven to be difficult to predict and prevent at the individual level,1–3 so much so that a recent analysis of individual risk assessments found a maximal positive predictive value of 5.5% for suicide death,2 and suicide continues to be a leading cause of death among adolescents age 10-19 years.4 By targeting modifiable risk factors at the population level, policy has the potential to extend our reach to people and subgroups that are missed by individual level interventions. This ecological study of adolescent suicide rates, state policies, and child maltreatment in US states from 2005-2019 and Kentucky counties from …

Swallow, Breathing And Survival: Sex-Specific Effects Of Opioids., Michael Frazure

Electronic Theses and Dissertations

This dissertation presents a series of studies examining mechanisms of deglutition and respiration, and how these vital processes are impacted by opioids. The experiments in Chapter Two investigated the role of the upper esophagus in airway protection through systematic activation of pharyngeal and esophageal mechanoreceptors in a cat electromyography model. Chapter Three compared effects of opioid administration on breathing and swallowing between male and female rats, and found that females are more susceptible to opioid-induced depression of breathing and swallow than males. Findings from Chapters Two and Three led to the development of a translational model of opioid-induced dysphagia using …

Injury Induced Neuroplasticity And Cell Specific Targeting Of The Lumbar Enlargement For Gene Therapy., Brandon Lee Brown

Electronic Theses and Dissertations

This dissertation is an examination of spinal cord injury induced neuroplasticity and tests whether noninvasive gene therapy can successfully target neurons in the lumbar spinal cord. It begins with an overview of neural control of locomotion and a brief summary of therapeutics that are used and/or in development for treating spinal anatomically characterize s subset of neurons in the spinal cord, long ascending propriospinal neurons, that are involved in interlimb coordination. Characterization of these neurons allows for subsequent evaluation of their potential involvement in injury induced neuroplasticity. This dissertation is divided into five chapters, covering spinal cord injury and therapeutics. …

Public Space And Well-Being: An Empirical Study Of Central Park In Old Louisville., Maryam Entezam

Electronic Theses and Dissertations

Urban green spaces have been receiving attention in urban planning and the health profession in the 21^st century as environmental elements that contribute to well-being. This dissertation explored the relationship between green space usage and individuals’ physical, mental, and social well-being. This empirical research focused on Central Park in Old Louisville to examine how residents use the park and whether it contributes to the well-being of residents. After exploring the existing literature, I identified four well-being indices: (1) perceived health (PHI), (2) health outcome (HOI), (3) mental well-being (MWI), and (4) social well-being (SWI). Frequent Park usage is expected …

Aurka Inhibition-Based Combination Therapy Approaches In Glioblastoma., Muge Sak

Electronic Theses and Dissertations

Glioblastoma is the most common and aggressive central nervous system tumor in adults with a 6% survival rate. Decades of research for improving life expectancy and quality of life have been ineffective. The discovery of better treatment strategies is urgent to improve the survival rates for glioblastoma patients. Aurora Kinase A is a regulator of tumor progression and is overexpressed in glioblastoma. We used a specific Aurora Kinase A inhibitor alisertib in combination with DNA-damaging platinum agent carboplatin or brain-penetrating taxane TPI 287. We investigated the efficacy of these combinations in treating in vitro and in vivo tissue culture models …

Kdm5b As A Potential Epigenetic Regulator Of Cardiomyocyte Regeneration And Cell Cycle Activation., Dana Hammouri

Electronic Theses and Dissertations

The limited regenerative capacity of adult cardiomyocytes (CMs) is manifested in prevalent morbidity and mortality associated with ischemic heart disease. We previously demonstrated that a combination of four cell cycle factors (4F) promotes efficient cell division in differentiated CMs. The temporal transcriptional reprogramming in the 4F-transduced CMs indicates that epigenetic modifications mediate the cell cycle progression. Through small molecule screening, we evaluated the epigenetic impact on CM’s response in the 4F-transduced CMs. We identified the histone demethylase 5B (KDM5B), which through in vitro and ex vivo genetic knockdown and overexpression studies, exhibited a modulative effect on CM’s cell cycle plasticity …

Teachers And Administrators' Perceptions Of The Implementation Of District Student Conduct Procedures., Amy Ghibaudy

Electronic Theses and Dissertations

While there is a body of research about student conduct policies and procedures, there is a lack of research about how different role groups work together to implement these procedures and have a positive working interpersonal relationship. This sequential mixed methods case study design takes place in a large urban school district. In this study, I investigate the perceptions that educators have on the implementation of student conduct procedures in their school. I also explore how their perceptions of each other shape their interpersonal relationships. I used Normalization Process Theory (NPT) as my guiding theoretical framework. This study drew upon …

Promotional Communication For A College Food Pantry: Findings From A Cross-Sectional Assessment Of Socioecological Variables Related To Past Use Of A Campus-Based Food Pantry., Bunny Marie Hayes

Electronic Theses and Dissertations

Objective: This study examined differences between users and non-users of campus food pantry, conducted communication audit, and made recommendations for future food pantry communication. Methods: Cross-sectional twofold study, first analyzing existing intrapersonal, interpersonal, and environmental data to test predictors of campus food pantry usage characteristics, using inferential statistics. Secondly, conducting a communication audit that evaluates the reach of student communication. Results: Significant differences were found between users and non-users of food pantry that support hypotheses in relation to gender, age, race, class, marital status, housing type, housing description, and Pell eligibility. Findings could not support hypothesized differences in first-generation status. …

Novel Insights Into Oligodendrocyte Biology From Developmental Myelination Studies In Autophagy Deficient Mice And Analysis Of Oligodendrocyte Translatome Response To Contusive Spinal Cord Injury., Michael David Forston

Electronic Theses and Dissertations

Loss of myelin causes severe neurological disorders and functional deficits in white matter injuries (WMI) such as traumatic spinal cord injury (SCI). This dissertation is focused on autophagy in OL development and the OL translatome after SCI. Chapter I describes the history of myelin, OL development, and their involvement in neurodegenerative diseases and SCI. The proteostasis network, in particular autophagy, and its contributions to white matter pathology is discussed. It concludes examining advantages and disadvantages of unbiased omics tools, like RiboTag, to study transcriptional/translational landscapes after SCI. Chapter II focuses on autophagy in OPC/OL differentiation, survival, and proper myelination in …

Connectivity Of Amygdala Somatostatin-Expressing Neurons And Their Role In Taste-Guided Behavior., Jane Jeruto Bartonjo

Electronic Theses and Dissertations

The nucleus of solitary tract (NST) and parabrachial nucleus (PBN) represent the first and second central synapses of ascending gustatory information. Neural processing in these nuclei is influenced by descending input from forebrain regions such as the central nucleus of the amygdala (CeA). In mice, we have shown that somatostatin (Sst) expressing neurons of CeA that project to NST and PBN are largely distinct cell populations and optogenetic inhibition of the CeA/Sst-to-NST subpopulation increases the intake of high concentrations of quinine with no apparent effect on sucrose intake. Synaptic connectivity of these cells is needed to understand the possible mechanisms …

Incidence And Determinants Of Hypertensive Disorders Of Pregnancy In The Us: Hospitalization Discharge Rate For Preeclampsia, Eclampsia, And Gestational Hypertensions, 2016-2018., Kahir S. Jawad

Electronic Theses and Dissertations

Background: Hypertension remains one of the most prevalent medical issues in pregnancy. It contributes considerably to maternal and fetal morbidity and mortality, making it one of the most significant public health problems. Although various epidemiological studies have been conducted over the past decades to assess the disease incidence and key risk factors associated with hypertensive disorders of pregnancy, current incidence rates and trends are lacking. This is a novel and significant study because there are no current population-based incidence estimates of hypertensive disorders of pregnancy and their subtypes and very few studies with the power to explore a wide range …

The Influence Of Power On Racial Identity And Social Power: Learning While A Minority In A Bullitt County High School In Kentucky., Michele Johnson

Electronic Theses and Dissertations

The purpose of this phenomenological study is to examine the influence of power on racial identity and social awareness of minority high schools’ students in Bullitt County, Kentucky. The research will come from the student perspective of those attending high school with students predominantly from another racial background. Using purposeful sampling, 12 students participated in semi-structured interviews, providing insight into three research questions regarding racial identity, social power, and social awareness. Student participants used their voice to share their lived educational experiences attending school with students from another racial background. Interviews were transcribed, coded and analyzed using In Vivo and …

The Relationship Between High School Stem Courses And Students Attending Low-Income Schools' College Major And Career Choices: A Social Cognitive Perspective., Don Bacon

Electronic Theses and Dissertations

Science, technology, engineering, and mathematics (STEM) education has received significant attention in the United States since the Space Race with Russia beginning in the 1950s. Most recently, STEM education has received national attention because of the scarcity of qualified STEM graduates taking on the growing number of STEM jobs in the United States. Additionally, an issue exists within STEM college majors and careers, a lack of Black, Latinx, and female students are pursuing these fields hurting the overall number of STEM college students and career holders and negatively impacts the diversity within STEM fields in the United States. The purpose …

Development And Applications Of Novel And Practical Fluorination Reagents., Yuhao Yang

Electronic Theses and Dissertations

The fluorine (F) atom has distinctive properties such as the highest electronegativity, small size, low polarizability, and strong C–F bond strength. Not surprisingly, fluorinated organic compounds have garnered significant attention in the pharmaceutical, agrochemical, and material fields. Since organofluorides are very rare in nature, we need fluorination reagents to help us transfer fluorine into the organic molecules. In past decades, a vast number of fluorination reagents have been developed and many of them are commercially available now. However, there is still much room for the improvement of these reagents. Our target is to develop novel and practical fluorination reagents to …

New Methodologies For Sustainable Organic Synthesis In Water., Sudripet Sharma

Electronic Theses and Dissertations

Water is stable, benign, and green solvent. Its usage as a solvent in organic synthesis is significantly enhanced by micellar catalysis. However, replacing water as a reaction medium in organic synthesis is not sufficient to meet the sustainability challenges—excessive organic solvents are still required for product isolation and purification. Notably, solvents used in syntheses contribute to more than 80% of waste generation. In addition to solvents, the use of palladium in large amounts is also a problem for the future as it is a precious, low-abundance metal, and its supply is dwindling. Therefore, this dissertation highlights the various sustainable protocols …

Penalized Bayesian Exponential Random Graph Models., Vicki Modisette

Electronic Theses and Dissertations

Networks have the critical ability to represent the complex interconnectedness of social relationships, biological processes, and the spread of diseases and information. Exponential random graph models (ERGM) are one of the popular statistical methods for analyzing network data. ERGM, however, struggle with computational challenges and degeneracy issues, further exacerbated by their inability to handle high-dimensional network data. Bayesian techniques provide a promising avenue to overcome these two problems. This paper considers penalized Bayesian exponential random graph models with adaptive lasso and adaptive ridge penalties to perform variable selection and reduce multicollinearity on a variety of networks. The experimental results demonstrate …

Exploring The Lived Experiences Of Dysphoric Milk Ejection Reflex During Postpartum Breastfeeding: A Phenomenological Study, Stephanie Herr, Jessica Devido, Richard Zoucha, Jill Demirci

Electronic Theses and Dissertations

This study sought to explore the lived experiences of Dysphoric Milk Ejection Reflex (D-MER) during postpartum breastfeeding. A phenomenological method based on Giorgi’s phenomenological underpinnings was used. The setting for this study was virtual interviews in a secure online platform. The sample consisted of 13 participants, self-identifying as experiencing D-MER. Semi-structured interviews, with thematic analysis of transcription were conducted. Four major themes were identified: 1) Breastfeeding concessions and toleration; 2) Something does not feel “normal”; 3) I remember a feeling like this before 4) This is real, and recognition is validating. Conclusions were that women of this study value the …

A Qualitative Content Analysis Of Nigerian Popular Music Genres: A Culture And Heritage Approach To Nation Branding, Cecilia Ashibel

Electronic Theses and Dissertations

This thesis explores the potential of Nigerian popular music as an approach to nation branding. The study employs qualitative content analysis to analyze select Nigerian music genres to examine how Nigeria is portrayed to international audiences and the economic benefits that can be derived from this form of branding. The analysis focuses on narrative themes of “the value of hard work,” “ethnic pride,” “lavish lifestyle,” and the impact of differences which were derived from the data. Findings indicate that Nigeria is globally reckoned for its musical prowess and rich cultural heritage. In highlighting the role of music in Nigeria’s political …

Sexual Trauma, Health, And The Moderating Effect Of Psychological Flexibility And Inflexibility, Gabrielle A. Caselman

Electronic Theses and Dissertations

Sexual trauma is linked to adverse health outcomes (e.g., D’Andre et al., 2011). Given the negative sequelae of sexual trauma, exploration of factors that influence the relation between sexual trauma and health outcomes is crucial. Current literature suggests that psychological flexibility and inflexibility may be factors in promotion of individuals’ health or pathology (e.g., Gloster et al., 2017). The current study sought to explore the variability in psychological flexibility and inflexibility among participants and the potential moderating effects of psychological flexibility and inflexibility on the relation between sexual trauma and both mental and physical health outcomes.

Moderation analyses failed to …

Visibility Based Hospital Inpatient Unit Design., Uttam Karki

Electronic Theses and Dissertations

Patient fall is one of the adverse events in an inpatient unit of a hospital that can lead to disability and/or mortality. Healthcare literature suggests that increased visibility of patients by unit nurses is essential to improve patient monitoring and, in turn, reduce falls. However, such research has been descriptive in nature and does not provide an understanding of the characteristics of an optimal inpatient unit layout from a visibility-standpoint. This dissertation fills significant voids in this domain and adds much-needed realism to develop insights that hospital decision-makers can use to design their inpatient unit layout. Our first contribution (Chapter …

A Data-Driven Multi-Regime Approach For Predicting Real-Time Energy Consumption Of Industrial Machines., Abdulgani Kahraman

Electronic Theses and Dissertations

This thesis focuses on methods for improving energy consumption prediction performance in complex industrial machines. Working with real-world industrial machines brings several challenges, including data access, algorithmic bias, data privacy, and the interpretation of machine learning algorithms. To effectively manage energy consumption in the industrial sector, it is essential to develop a framework that enhances prediction performance, reduces energy costs, and mitigates air pollution in heavy industrial machine operations. This study aims to assist managers in making informed decisions and driving the transition towards green manufacturing. The energy consumption of industrial machinery is substantial, and the recent increase in CO2 …

Epitranscriptomic Regulation In Breast Cancer And Pcb-Induced Liver Disease., Belinda Petri

Electronic Theses and Dissertations

Post-transcriptional RNA modifications including N6-methyladenosine (m6A) regulate mRNA stability, splicing, and translation. My research examined m6A in two disease models: breast cancer (BCa) and non-alcoholic fatty liver disease (NAFLD). Acquired resistance to endocrine therapies (ET) develops in approximately 20% of BCa patients with estrogen receptor α positive (ER+) tumors following treatment. The mechanisms by which tumor cells evade ET are not completely understood. Using a cell line model, we investigated the role of an m6A reader protein, HNRNPA2B1 (A2B1) that is upregulated in ET-resistant ER+ BCa cells. Stable overexpression of A2B1 in ET-sensitive MCF-7 cells (MCF-7-A2B1), results in ET resistance, …

Cad System For Early Diagnosis Of Diabetic Retinopathy Based On 3d Extracted Imaging Markers., Ahmed Sleman

Electronic Theses and Dissertations

This dissertation makes significant contributions to the field of ophthalmology, addressing the segmentation of retinal layers and the diagnosis of diabetic retinopathy (DR). The first contribution is a novel 3D segmentation approach that leverages the patientspecific anatomy of retinal layers. This approach demonstrates superior accuracy in segmenting all retinal layers from a 3D retinal image compared to current state-of-the-art methods. It also offers enhanced speed, enabling potential clinical applications. The proposed segmentation approach holds great potential for supporting surgical planning and guidance in retinal procedures such as retinal detachment repair or macular hole closure. Surgeons can benefit from the accurate …