Digital Commons Network^™

Coordinate Regulation Of The Wnt And Hippo Pathways By The Novel Ras Effector Nore1a., Marvin Lee Schmidt Jr.

Electronic Theses and Dissertations

Ras is the most frequently activated oncogene found in human cancer, but its mechanisms of action remain only partially understood. Ras activates multiple signaling pathways in order to promote transformation, but can also exhibit a potent ability to induce growth arrest and death. NORE1A (RASSF5) is a direct Ras effector that acts as a tumor suppressor promoting senescence and apoptosis. Its expression is frequently lost in human tumors and its mechanism of action remains unclear. Here I show that NORE1A forms a direct, Ras regulated, complex with β-TrCP, the substrate recognition component of the SCF-β-TrCP ubiquitin ligase complex. NORE1A also …

Exercise Mitigates The Effects Of Hyperhomocysteinemia On Adverse Skeletal Muscle Remodeling., Lee Winchester

Electronic Theses and Dissertations

Background: Hyperhomocysteinemia (HHcy) is heavily implicated in diabetes and cardiovascular disease. HHcy is known for causing inflammation and vascular remodeling, particularly through production of reactive oxygen species (ROS) and matrix metalloproteinase-9 (MMP-9). Although its impact on skeletal muscle is rather unclear, HHcy is known to cause skeletal muscle weakness and functional impairment. The impact of HHcy on inflammation makes it seem likely that HHcy causes skeletal muscle fibrosis through induction of inflammatory factors and destructive macrophages. Exercise has been shown to reduce homocysteine levels and therefore, could serve as a promising intervention for HHcy. The purpose of this study was …

Undead Empire: How Folklore Animates The Human Corpse In Nineteenth-Century British Literature, Charles Hoge

Electronic Theses and Dissertations

This dissertation explores representations of the human corpse in nineteenth-century British literature and ephemeral culture as a dynamic, multidirectional vehicle used by writers and readers to help articulate emerging anxieties that were complicating the very idea of death. Using cultural criticism as its primary critical heuristic filter, this project analyzes how the lingering influence of folklore animates the human corpses that populate canonical and extra-canonical nineteenth-century British literature.

The first chapter examines the treatment of the human corpse through burial and mourning rituals, as specific developments within these procedures provide interpretive windows into how the idea of death was quickly …

The Search For Authentic Travel In Early Twentieth-Century British Magazines, Christina Bertrand Firebaugh

Electronic Theses and Dissertations

Edwardian travel writing between roughly 1905 and 1914 serves as a bridge between the closing of the long Victorian period, the beginnings of modernism, and the changes to come in the twentieth century. The search for authentic experience characterizes travel writing in the Edwardian era. Significant cultural, technological, and social changes caused Edwardians to examine their perceptions about possibilities for authentic engagement with other places and people in their travels. As a result, Edwardian travel writers explore various methods by which to engage authentically with other cultures. Drawing on literary theory, anthropology, and cultural studies, this dissertation examines a number …

Body Image., Emma Sharps 1989-

Electronic Theses and Dissertations

My thesis and the corresponding exhibition will look at contemporary artists, specifically Jen Davis, Lauren Greenfield, Leslie Lyons and Licia Priest, who examine and oppose the negative effects that art and pop culture have had on perceptions of the female body and, especially, on women’s perceptions of their own bodies. Focusing on the last three decades, I will contextualize my exhibition by examining art historical and feminist texts that analyze representations of female bodies. My project will be informed by contemporary psychological and sociological studies of women’s attitudes towards their bodies: Joan Brumberg’s The Body Project, Naomi Wolf’s The Beauty …

Appalachian Studies As An Academic And Activist Field, 1970-1982, Emily Booker

Electronic Theses and Dissertations

This thesis examines the formation of Appalachian studies as an academic field from roughly 1970 to 1982. First, this thesis analyses regionalism and what defines a region, focusing on the different contexts and narratives through which Appalachia has been described. Second, this thesis examines how scholars and activists in the region challenged prevailing narratives and sought new ways to examine and contextualize the region. Efforts to challenge stereotypes and address the social, political, and economic problems of the region galvanized academics and activists alike. Despite their similar work and shared vision for an interdisciplinary regional field, academics and activists often …

A Few Good Men And Women : The Rhetorical Constitution Of Military Personnel Identity., Ashly Bender Smith

Electronic Theses and Dissertations

In this dissertation, I examine the public negotiation of service member identity by multiple stakeholders as a way to better understand the available rhetorical strategies for affecting ideological constructions of identity. While current Rhetoric and Composition research attends mostly to student-veterans, I draw on cultural and rhetorical theorists, such as Louis Althusser, Kenneth Burke, Maurice Charland, to identify the rhetorical approaches used to construct military personnel identity, particularly in the post-9/11 era. Through analysis of films, recruiting materials, and the publicly-shared stories of personnel, I extend current understandings of constitutive rhetoric and rhetorical identification—which tend to focus on the work …

Southerner As Other: Exploring Regional Identity Through The Southern Vampire, Lauren N. Fowler

Electronic Theses and Dissertations

Since its conception in folklore and superstition, the vampire has had an innate ability to reflect the environment of the culture that creates it. Each manifestation of this being is entirely unique to the culture in which it is born. The vampire of the American South is no exception to this idea. As a region with a particularly tumultuous history, the South has been molded by many cultural influences. Religion, sexuality, and race are some of the most notable factors to have impacted the area. Many Southern authors writing vampire fiction explore the fears, stereotypes, and prejudices of the culture …

Under The Shadow Of The Awful Gallows-Tree: The Murder Trials Of Thomas Dula And Ann Melton As A Case Study In Gender And Power In Reconstruction Era Western North Carolina, Heather L. Miller

Electronic Theses and Dissertations

This is a micro-history that explores everyday life on a small scale by tracing the common, if elusive lives of Thomas Dula, Ann Melton, and Laura Foster, and the communities they lived in, to explore the culture in which they lived—and died. Reactions to the murder unleashed an outpouring of discourse embedded in broader, national debates concerning gender roles. The dominant cultural theme that emerged from the murder trials as reflected in middle-class newspapers maintained that true women did not kill and real men acted as gentlemen and defenders of women’s honor. The project mines a wealth of primary source …

Nowhere, Danielle N. Winger

Electronic Theses and Dissertations

The artist discusses her Masters of Fine Arts exhibition, Nowhere, held at the Tipton Gallery located in downtown Johnson City from March 30 through April 9, 2015. The works included in the exhibition consist of a collection of oil paintings on both canvas and panel, and a series of mixed media collage paintings that explore how time and memory affect her personal connection to spaces she has inhabited.

Ideas discussed include painting, process, cropping, memory, selective memory, forged memory, false memory, fragmenting, dreams, childhood, mnemic image, time, simulacra, simulation, home, beds, bedrooms, bathrooms, abstracting imagery, landscape, Freud, Lacan, Gaston Bachelard, …

Macrophage Cox-2 As A Target For Imaging And Therapy Of Inflammatory Diseases Using Theranostic Nanoemulsions, Sravan Kumar Patel

Electronic Theses and Dissertations

Personalized medicine can be an approach to address the unsatisfactory treatment outcomes in inflammatory conditions such as cancer, arthritis, and cardiovascular diseases. A common feature of chronic diseases is the infiltration of pro-inflammatory macrophages at the disease loci. Infiltrating macrophages have been previously utilized for disease diagnosis. These features suggest that macrophages can be broadly applicable targets for simultaneous therapy and diagnosis. Cyclooxygenase-2 (COX-2), an enzyme involved in the biosynthesis of a lipid inflammatory mediator, prostaglandin E2 (PGE2), is over expressed in macrophages infiltrating the pathological site. Inhibition of PGE2 leads to reduced inflammation, pain and macrophage infiltration. To utilize …

Curating Ali`I Collections: Responsibility, Sensibility, And Contextualization In Hawai'i-Based Museums, Halenakekanakalawai`Aomiloli`I Ka`Ili`Ehu Kapuni-Reynolds

Electronic Theses and Dissertations

This thesis explores the curation of aliʻi collections in the Bernice Pauahi Bishop Museum and the Lyman House Memorial Museum. The aliʻi were once the ruling class of Hawai'i, whose chiefly ranks and statuses reflected their prestigious and complicated moʻokūʻauhau (genealogies). Although the aliʻi are no longer a visible social class in Hawai'i, their moʻokūʻauhau (genealogies) and moʻolelo (stories) are continually honored and preserved within the walls of museums. Through the use of a research design that draws from multiple museologies, indigenous epistemologies, and anthropological theories and methods, I examine the physical care, storage, exhibition, and interpretation of aliʻi collections, …

Lifting The Veil On Hindi Film Song Sequences: An Approach To Analysis, Maria A. Souliotis

Electronic Theses and Dissertations

This thesis seeks to augment previous scholarly research on Hindi film song through the presentation of a multivalent approach to thoroughly understanding and interpreting Hindi film song sequences. In a case study of the song sequence “Pardā Haı̃ Pardā” ("There Is a Veil,"? from Manmohan Desai's 1977 film Amar Akbar Anthony), the three essential elements of these sequences (on-screen visuals, text, and music) are connected to the context of South Asian history and culture to demonstrate how scholarly approaches to music, film, and cultural studies can be united to create a more interdisciplinary approach to analysis. The approach also …

Meetup And Social Capital: Building Community In The Digital Age, Danielle Vaughn

Electronic Theses and Dissertations

In order to understand the complex relationship between new media and social capital, this thesis explores the lived experiences of individuals who are actively seeking some form of connection through MeetUp.com. Through participant observation, critical discourse analysis, and semi-structured interviews, the findings of this research illuminate the myriad ways in which participation with new media platforms intersects with individuals’ psychosocial well-being through the formation of social capital. While social capital has traditionally been thought about in terms of its different forms, and different benefits, this research furthers the literature by demonstrating that the values of social capital are not limited …

Perceptions Of School Reform In A Post-Nclb World: A Cathartic Recovery Of The Purpose And A ‘Shining-Through’ Of The Spirit Of Education, Timothy Arkell Price

Electronic Theses and Dissertations

This study used a Constructivist Grounded Theory methodology to understand the varying perceptions held by different stakeholding groups (state legislators, superintendents, building administrators, teachers, and parents) about No Child Left Behind (NCLB) and other related reform efforts such as the Common Core. 12 participants from these five stakeholding groups were purposefully chosen, all from the state of Idaho, and in-depth interviews were performed, parsed out into three phases to inductively invite themes and categories for inquiry. Following each interview, a socio-semiotic analysis was performed using participant language in an integrated effort to identify deeply held beliefs and perceptions of school …

Dialogic Constructions Of Monogamy: The Discursive Struggles Of Mono-Normativity And Mono-Realism, Stephanie K. Webb

Electronic Theses and Dissertations

Through the lens of relational dialectics theory (RDT; Baxter, 2011), this study examines the various discourses of monogamy and works to understand how monogamy is granted power through communication. Data for the study was gathered via qualitative surveys. A contrapuntal analysis identified two competing discourses: (1) the discourse of mono-normativity and (2) the discourse of mono-realism. The discourse of mono-normativity is taken for granted as the ordinary way to conduct romantic relationships. As such, it is granted power and idealized. The discourse of mono-realism disrupts the discourse of mono-normativity, as it challenges the idealization of monogamous romantic relationships. The discourses …

Feel-Good Giving: The Mythic Construction Of Generosity In Millions, Grace Y. Chiou

Electronic Theses and Dissertations

The question of what generosity is and how it is practiced in relation to the neoliberal contexts of late capitalism has emerged as a subject of interest across a variety of fields. Instead of placing emphasis on the recipient and the cause or structural inequalities contributing to the need for generosity, new practices of giving have appeared on a variety of media platforms and have been performed by a host of celebrities, sports figures, and politicians that emphasize the giver's moral goodness.

By using a critical cultural studies approach, this dissertation demonstrates that in the visual culture of humanitarianism representations …

Imagining The Scandal Of The Cross With Graphic/Novel Reading, Elizabeth Rae Coody

Electronic Theses and Dissertations

For countless adherents to the Christian tradition, the Cross functions as a symbol of divine power. For the earliest Christians, however, this overwhelmingly positive valuation of crosses would have been unintelligible. Living under Roman rule, their immediate understanding of crosses would have been as instruments of execution and thus symbols of the power and victory belonging to a foreign empire rather than to the Lord they worshipped. For them, the crucifixion was a traumatic event in which the Messiah died shamefully. It is for these reasons that the scandal of the Cross is a prominent theme in the New Testament, …

Going Viral: A Critical, Post-Structural Exploration Of Feminist Culture Jamming As Cultural Therapeutic, Leah Boisen

Electronic Theses and Dissertations

Using a discursive framework informed by critical theory and post-structural philosophy (particularly via the works of Michel Foucault and Judith Butler), this dissertation proposes the existence of pathology at both individual and cultural levels. Shifting away from the language of social problems, I propose that the pervasive and harmful ideology of patriarchy promulgated through discourse constitutes not just a problem, but a cultural sickness. Calling for a revised understanding of the relationship between culture and individual, and a new respect for the powerfully constitutive role of discourse, I argue that many of the common symptom patterns and problems we treat …

Safety Climate And Safety Outcomes In Aircraft Maintenance: A Mediating Effect Of Employee Turnover And Safety Motivation, Muhanna Alnoaimi

Electronic Theses and Dissertations

Aircraft maintenance is viewed as a critical safety component in general and military aviation industries, and thus it is crucial to identify the factors that may affect aircraft maintenance. Because the safety climate is considered as a leading indicator of safety performance and safety outcomes, this study utilized this safety climate approach to develop a model which can explain the relationships between employee turnover, safety motivation, self-reported unsafe acts, reporting unsafe behaviors, incidents, and injuries in the aviation maintenance environment. This study included a sample of 283 technicians in military aircraft maintenance units who participated in a cross-sectional random survey. …

Disciplinary Mythologies: A Rhetorical-Cultural Analysis Of Performance Enhancement Technologies In Sports, John Lamothe

Electronic Theses and Dissertations

In sports discourse, the relationship between athletics and technology is often paradoxical. On the one hand, modern sports rely on technology at every level, from training and tracking of players to the equipment and apparel used by athletes to the game strategies and playing fields themselves. Nearly all of these technologies are intended to increase athletic performance on some level. And yet, certain performance enhancement technologies can be criticized for being antithetical to the spirit of sports, which is framed as being a strictly natural and pure human endeavor. Using a rhetorical-cultural methodological approach, popular sports discourse is analyzed to …

Way Of The Butterfly: A Journey Towards Transformation Through Self-Portraits In-Between, Masami Koshikawa

Electronic Theses and Dissertations

It has not been easy for me to talk about myself or describe my feelings or thoughts. Coming from Japan, a collective society, we typically are not raised to do so. Throughout the MFA program at UCF, I have shared my feelings and thoughts through my work. It is important to discuss and inform others of our cultural similarities and differences so that we may gain a better understanding of each other. This process has helped me grow not only on an artistic level, but also on a personal level. My journey towards integration has led me to a meaningful …

Composing A Literary Adoption Memoir And Self Through Creative Nonfiction Memoir Writing, Jamie K. Nagy

Electronic Theses and Dissertations

Adoption writings span across various forms, such as fiction, non-fiction, essays, poetry, theatre, and scholarly fields of study. While many of these adoption writings speak to the complexities of adoption, the general public still tends to see adoption “such a beautiful thing” to do—as the best plan for the child, a noble act, a selfless decision, and a solution to a long-standing social issue. This thesis explores the “literary adoption memoir”—artful writings about real life happenings; my contribution to this genre addresses the complexities of the closed adoption era, transnational/transracial adoption, and parenting an adoptee as an adult adoptee. For …

Experiences Of Playing Massively Multiplayer Online Role-Playing Games: A Phenomenological Exploration, Jacob Rusczek

Electronic Theses and Dissertations

This dissertation presents an interpretative phenomenological analysis of the experience of being engaged in a massively multiplayer online role-playing game (MMORPG). These games have become increasingly popular over the past decade and have earned the reputation of being highly engrossing or even addicting. In this study, five long-term players were interviewed in person. For a portion of the interviews, the researcher observed the participants playing their games. The interviews were transcribed and subsequently analyzed using interpretive phenomenological analysis, which yielded individual and shared themes. Individual themes are first presented, which provides a rich sense of each participant's particular way of …

Macrophage Cox-2 As A Target For Imaging And Therapy Of Inflammatory Diseases Using Theranostic Nanoemulsions, Sravan Kumar Patel

Electronic Theses and Dissertations

Personalized medicine can be an approach to address the unsatisfactory treatment outcomes in inflammatory conditions such as cancer, arthritis, and cardiovascular diseases. A common feature of chronic diseases is the infiltration of pro-inflammatory macrophages at the disease loci. Infiltrating macrophages have been previously utilized for disease diagnosis. These features suggest that macrophages can be broadly applicable targets for simultaneous therapy and diagnosis. Cyclooxygenase-2 (COX-2), an enzyme involved in the biosynthesis of a lipid inflammatory mediator, prostaglandin E2 (PGE2), is over expressed in macrophages infiltrating the pathological site. Inhibition of PGE2 leads to reduced inflammation, pain and macrophage infiltration. To utilize …

Pocket Monsters And Pirate Treasure: Fantasy And Social Platforms In The 21st Century, Jacob Waalk

Electronic Theses and Dissertations

POCKET MONSTERS AND PIRATE TREASURE: FANTASY AND SOCIAL PLATFORMS IN THE 21ST CENTURY is an anthropology project examining media, fantasy, ideology, and social groups in order to build a better foundation for the ways in which economic and social changes influence social networking, popular media, and values by using the anime-manga subculture as an example. The thesis draws from three major theorists: Thomas LaMarre, Anne Allison, and Ian Condry as well as major anthropological theorists such as Pierre Bourdieu. As an ethnography, the project was split into two sections: one consisting of interviews with eight anime-manga subculture participants drawn primarily …

Cliteracy And Justice For All : A Critical Rhetorical Analysis Of Sophia Wallace’S Cliteracy Campaign, Vanessa Condon

Electronic Theses and Dissertations

Female sexuality is constantly restricted in public discourse in the United States. To combat this, Sophia Wallace created the Cliteracy campaign: a project that sought to challenge the stigmatization of female genitals. Wallace’s attempt to create a new language regarding female sex and sexuality revealed critical implications for how we discuss sex in American culture. For an in depth analysis, I utilized feminist, materialist, and social movement rhetorical lenses. This study revealed that while text is viewed as an objective mode of communication, however, it is ingrained with hierarchical societal constraints. Moreover, Wallace’s rhetoric suggested that a god term is …

An Evaluation Of Geophysical Methods In The Detection Of Toddler-Sized Burials During The First Six Months Of Burials, Paul Sullivan Martin

Electronic Theses and Dissertations

Geophysical survey has become a major tool in the search for clandestine graves associated with missing person cases. However, relatively little research has been done to evaluate the efficacy of different instruments. Ground-penetrating Radar (GPR), magnetometry, resistivity, conductivity, and susceptibility survey data were collected over the first six months of interment at approximately 30-day intervals for two research plots: an open grassy area and a wooded area. Each area contained five pig burials representing toddler-size (less than 50 pounds) remains and two areas of disturbance or false burials to serve as control graves. The resultant imagery was evaluated in terms …

"I'M Not Talking To Myself, I'M Having A Parent-Teacher Conference!": A Study Of Literacy Practices And Mediation Within Homeschooling Families, Joshua Corlew

Electronic Theses and Dissertations

Homeschooling is a dynamic learning and living community producing a growing percentage of our nation*s college-ready students. Serious academic studies of homeschooling remain scarce, and those that exist tend to come out of sociology and anthropology. Through an analysis of the literacy practices that constitute the work of homeschooling, this study offers findings and conclusions relevant to current discourses in the fields of literacy studies and rhetoric and composition. These include discussions on the ways technology is reshaping and individualizing traditional models of literacy learning and composing, as well as the growing research on the specific actions taken by literacy …

African American Vernacular English (Aave) In The Classroom: The Attitudes And Ideologies Of Urban Educators Toward Aave, Melanie Hines Knapp

Electronic Theses and Dissertations

The study of embracing African American Vernacular English (AAVE) in the classroom is often misunderstood. AAVE is an informal dialect spoken by many African Americans in the United States. Considering this dialect is spoken by many African American students, teachers have struggled with the appropriateness and legitimacy of its usage in the classroom for years. In order for teachers to help students maintain the richness and character of AAVE, yet allow students to learn and incorporate Standrd English conventions, they must embrace culturally relevant instruction.

Culturally relevant instruction (CRI) is an instructional approach that involves using students’ cultural and linguistic …