Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Life Sciences (47)
- Physical Sciences and Mathematics (44)
- Chemistry (26)
- Medicine and Health Sciences (18)
- Biochemistry, Biophysics, and Structural Biology (13)
-
- Pharmacy and Pharmaceutical Sciences (11)
- Biology (10)
- Engineering (8)
- Environmental Sciences (8)
- Organic Chemistry (8)
- Plant Sciences (8)
- Biochemistry (7)
- Molecular Biology (7)
- Arts and Humanities (6)
- Ecology and Evolutionary Biology (6)
- Statistics and Probability (6)
- Cell and Developmental Biology (5)
- Microbiology (5)
- Animal Sciences (4)
- Genetics and Genomics (4)
- Natural Resources Management and Policy (4)
- Natural Resources and Conservation (4)
- Plant Biology (4)
- Cell Biology (3)
- Education (3)
- Electrical and Computer Engineering (3)
- Immunology and Infectious Disease (3)
- Physics (3)
- Terrestrial and Aquatic Ecology (3)
- Agronomy and Crop Sciences (2)
- Institution
- Keyword
-
- College of Natural Science and Mathematics (8)
- Biological Sciences (3)
- Breast cancer (3)
- Chemistry and Biochemistry (3)
- Docking (3)
-
- Abiotic stress (2)
- Arabidopsis (2)
- Biophysics (2)
- Biotic stress (2)
- Breast--Cancer--Genetic aspects (2)
- Cancer (2)
- Click chemistry (2)
- College of Arts Humanities and Social Sciences (2)
- Daniel Felix Ritchie School of Engineering and Computer Science (2)
- HIV (2)
- Maize (2)
- Medicinal chemistry (2)
- Nanoparticles (2)
- Organic chemistry (2)
- Phytoalexin (2)
- Polyamines (2)
- Polyphenols (2)
- Resveratrol (2)
- Salicylic acid (2)
- Stilbenoid (2)
- Synthesis (2)
- 1 (1)
- 2 (1)
- 3-triazole derivative (1)
- 5'-3' exoribonuclease 1 (1)
Articles 61 - 90 of 143
Full-Text Articles in Entire DC Network
Validation Of Integrated Coast-Ocean Model Cche2d-Coast And Development Of Wind Model, Afshin Gazerzadeh
Validation Of Integrated Coast-Ocean Model Cche2d-Coast And Development Of Wind Model, Afshin Gazerzadeh
Electronic Theses and Dissertations
The eastern and southern coastlines of the United States are two of the most cyclone-prone areas of the world. The effects of tropical cyclones vary mainly depending on wind intensity and geological features of the coast that it is crossing. Higher winds potentially generate higher storm surges and consequently larger floods occur along the coastlines. Therefore, it is critical to accurately predict winds, storm surge, and waves associated with a hurricane. In the present study, an integrated coastal and ocean process model, CCHE2D-Coast, is validated by assessing the model’s capabilities in simulating coast-ocean circulations driven by the astronomical tides on …
The Development Of Motuporamine Derivatives And An Investigation Into Their Biological Properties, Kristen Skruber
The Development Of Motuporamine Derivatives And An Investigation Into Their Biological Properties, Kristen Skruber
Electronic Theses and Dissertations
This project investigates the synthesis of a class of compounds derived from a marine-based natural product and probes how iterative changes to its structure affect its derivatives' biological efficacy. The compound class of interest are the motuporamines which were isolated from the sea sponge Xestospongia exigua collected off the coast of Motupore island in Papua, New Guinea. The compounds for this project are predicated upon dihydromotuporamine C (Motu33), the compound that has been shown to be both cytotoxic to MDA-MB231 breast carcinoma cells and has antimetastatic efficacy. The motuporamine scaffold contains a large fifteen-membered saturated macrocycle and an appended polyamine …
Pyroglutamylated Amyloid Beta Peptides Enhance Non-Fibrillogenic Aggregation Of The Unmodified Peptide, Gregory Goldblatt
Pyroglutamylated Amyloid Beta Peptides Enhance Non-Fibrillogenic Aggregation Of The Unmodified Peptide, Gregory Goldblatt
Electronic Theses and Dissertations
Alzheimer's disease (AD) is accompanied by abnormal extracellular deposition of amyloid b (Ab) peptide. This has led to the amyloid cascade hypothesis, causatively relating Ab with AD. While Ab deposits assume a fibrillar cross-b structure, prefibrillar oligomers of Ab have been identified as the main cytotoxic agents in AD. Pyroglutamylated amyloid beta (AbpE) peptides are N-terminally truncated and pyroglutamylated (at Glu3 or Glu11) Ab molecules that display enhanced cytotoxicity and represent up to 50% of total Ab in AD brains. AbpE significantly enhances the toxicity of unmodified Ab by an unknown mechanism. Although in situ Ab populations are heterogeneous, the …
By Book And School: The Politics Of Educational Reform In France And Algeria During The Early Third Republic, Michael Brooks
By Book And School: The Politics Of Educational Reform In France And Algeria During The Early Third Republic, Michael Brooks
Electronic Theses and Dissertations
During the era of New Imperialism, the newly-formed French Third Republic continued France's civilizing mission both in France and in Algeria. Founded on a series of reforms, republican leaders and educational experts judged primary level education taught in the French language to be the most effective means of uniting a linguistically and culturally diverse population in the metropole. These republican values, based on revolutionary tenet of universality, would help France to sustain a republican regime, would thwart attempts to reestablish monarchical rule, and would teach future French citizens what it meant to be politically active. At the same time, another …
Analysis Of Anacardic Acid On The Surface Of Pelargonium × Hortorum Using Matrix Assisted Laser Desorptoin Ionization Mass Spectrometry Imaging., Bryan Edward Wessel 1989-
Analysis Of Anacardic Acid On The Surface Of Pelargonium × Hortorum Using Matrix Assisted Laser Desorptoin Ionization Mass Spectrometry Imaging., Bryan Edward Wessel 1989-
Electronic Theses and Dissertations
The biosynthetic pathway leading to the production of anacardic acids (AnAcs) in glandular trichomes on the surface of geranium plants remains unclear. Anacardic acids are salicylic acid derivatives known to possess various medicinal benefits. Gene silencing techniques, such as RNA interference, could be useful in determining specific enzymes involved in the synthesis of AnAcs. However, it is first necessary to develop methodologies to image AnAcs. In this project, both fluorescence (FL) and mass spectral imaging (MSI) were tested. Our results indicate that cellular imaging of AnAcs, via FL, is not suitable because the spectral ranges of absorption and emission of …
Cytokine Dynamics, Diagnosis And Treatment Of Neuroinflammation In Chronic Constriction Injury Rat Model, Kiran Vasudeva
Cytokine Dynamics, Diagnosis And Treatment Of Neuroinflammation In Chronic Constriction Injury Rat Model, Kiran Vasudeva
Electronic Theses and Dissertations
Chronic neuropathic pain is a serious, worldwide health problem leading to life-long treatment and the possibility of significant disability. In this study, neuropathic pain was modeled using the chronic constriction injury (CCI) in rats. The CCI rats exhibited hypersensitivity (typical neuropathic pain symptom) to mechanical stimulation of the affected paw 11 days post-surgery, at a time when sham surgery animals did not. It is known that immune cells play a role in the development of neuropathic pain and to further explore the relationship between neuropathic pain and immune cells, we hypothesized that the infiltration of immune cells into the affected …
A High-Content Multiplexed Screening Platform For The Evaluation And Manipulation Of Force And Fatigue Of Adult Derived Skeletal Muscle Myotubes In Defined Serum-Free Medium, Christopher Mcaleer
A High-Content Multiplexed Screening Platform For The Evaluation And Manipulation Of Force And Fatigue Of Adult Derived Skeletal Muscle Myotubes In Defined Serum-Free Medium, Christopher Mcaleer
Electronic Theses and Dissertations
The overall focus of this project has two parts: First, was to develop a protocol utilizing serum-free media formulations and defined plating and culture techniques to create functional in vitro myotubes derived from adult skeletal muscle satellite cells. The second was to manipulate the inherent muscle parameters such as force output and fatigue of these myotubes by employing exercise regimes or by small molecule application. The importance of serum-free medium use for in vitro cultures is becoming increasingly important in creating functional systems that can be validated for drug testing by the Food and Drug Administration (FDA). Also, the study …
Mercury Methylation Potentials In Sediments An Ancient Cypress Wetland Using Species-Specific Isotope Dilution-Gc-Icp-Ms: Analytical Method Development And The Effect Of Sorbent Amendments, Derek Davin Bussan
Electronic Theses and Dissertations
A novel method was developed to measure mercury (Hg) directly in environmental solids using inductively coupled plasma mass spectrometry (ICP-MS) with online sample ashing. The method combines a direct mercury analyzer (DMA) that is based on sample combustion, Hg pre-concentration by amalgamation with gold, and atomic absorption spectrometry (AAS), with a high resolution ICP-MS. Unlike AAS, the ICP-MS is capable of individual isotope measurements allowing for accurate quantitation by isotope dilution mass spectrometry (IDMS) and for isotope tracer experiments. The method was validated using certified reference materials including sediment (NIST 2709), leaves (NIST 1547), and fish-muscle (DORM-3), with recoveries within …
Analyses Of 2002-2013 China’S Stock Market Using The Shared Frailty Model, Chao Tang
Analyses Of 2002-2013 China’S Stock Market Using The Shared Frailty Model, Chao Tang
Electronic Theses and Dissertations
This thesis adopts a survival model to analyze China’s stock market. The data used are the capitalization-weighted stock market index (CSI 300) and the 300 stocks for creating the index. We define the recurrent events using the daily return of the selected stocks and the index. A shared frailty model which incorporates the random effects is then used for analyses since the survival times of individual stocks are correlated. Maximization of penalized likelihood is presented to estimate the parameters in the model. The covariates are selected using the Akaike information criterion (AIC) and the variance inflation factor (VIF) to avoid …
Synthesis Of N-Heterocycles Through Cyclization-Triggered Tandem Additions To Alkynes And The Study Of Promoters In Ionic Reactions., Junbin Han
Electronic Theses and Dissertations
Our research mainly focused on three parts related to the rapid construction of N-heterocycles and the search for ionic reaction promoters. First, N-heterocycles of different ring sizes and with different substitution patterns constitute extremely important structure classes (e.g., alkaloids) in the search for bioactivity. A contemporary challenge in organic synthesis is the mapping of new chemical spaces through tandem or cascade reactions in an atom economical fashion. Our strategy to access these biologically important heterocycles is through a cyclization-triggered tandem addition to alkynes catalyzed by readily available alkynophilic coinage metals like copper. In this manner, a variety of functional groups …
Development Of A Light-Powered Microstructure : Enhancing Thermal Actuation With Near-Infrared Absorbent Gold Nanoparticles., Thomas Matthew Lucas
Development Of A Light-Powered Microstructure : Enhancing Thermal Actuation With Near-Infrared Absorbent Gold Nanoparticles., Thomas Matthew Lucas
Electronic Theses and Dissertations
Development of microscale actuating technologies has considerably added to the toolset for interacting with natural components at the cellular level. Small-scale actuators and switches have potential in areas such as microscale pumping and particle manipulation. Thermal actuation has been used with asymmetric geometry to create large deflections with high force relative to electrostatically driven systems. However, many thermally based techniques require a physical connection for power and operate outside the temperature range conducive for biological studies and medical applications. The work presented here describes the design of an out-of-plane bistable switch that responds to near-infrared light with wavelength-specific response. In …
Design And Evaluation Of A Propulsion System For Small, Compact, Low-Speed Maneuvering Underwater Vehicles, Florence M. Mbithi
Design And Evaluation Of A Propulsion System For Small, Compact, Low-Speed Maneuvering Underwater Vehicles, Florence M. Mbithi
Electronic Theses and Dissertations
Underwater vehicles used to perform precision inspection and non-destructive evaluation in tightly constrained or delicate underwater environments must be small, have low-speed maneuverability and a smooth streamlined outer shape with no appendages. In this thesis, the design and analysis of a new propulsion system for such underwater vehicles is presented. It consists primarily of a syringe and a plunger driven by a linear actuator and uses different inflow and outflow nozzles to provide continuous propulsive force. A prototype of the proposed propulsion mechanism is built and tested. The practical utility and potential efficacy of the system is demonstrated and assessed …
Synthesis And Study Of Chemo-Hydrothermally Derived Water-Soluble Chitosan And Chiosan-Metal Oxide Composites, Srijita Basumallick
Synthesis And Study Of Chemo-Hydrothermally Derived Water-Soluble Chitosan And Chiosan-Metal Oxide Composites, Srijita Basumallick
Electronic Theses and Dissertations
Chitosan (CS) is a man-made sugar based biopolymer derived from chitin, the second most abundant natural polymer after cellulose. Chitin is sourced from crustacean species such as shrimps and crabs. The chemical structure of chitin contains N-Acetyl D-glucosamine monomer units which forms CS upon deacetylation. In CS, ?-(1-4) linked D-glucosamine units are randomly distributed. Approximately 75% - 80% sugar units contains primary amine groups in commercially available low molecular weight CS. Biodegradability, low toxicity, mucoadhesive and transfecting properties of CS polymer are attractive for applications as oral and nasal drug delivery systems. Chitosan polymer is water insoluble at neutral pH. …
Cranberry Metabolites With Urinary Anti-Adhesion Activity, Christina M. Coleman
Cranberry Metabolites With Urinary Anti-Adhesion Activity, Christina M. Coleman
Electronic Theses and Dissertations
The fruit of the American cranberry (Vaccinium macrocarpon Aiton, Ericaceae) is a comfood and a top selling dietary supplement in the U.S. Cranberry juice is traditionally used for the prevention of urinary tract infections (UTIs), many of which are caused by P-fimbriated Escherichia coli. Human urine produced after cranberry juice consumption can prevent E. coli adhesion, but the urinary metabolites responsible for this activity are currently not known. High-molecular weight components of cranberry juice, specifically proanthocyanidin oligomers (PACs), are currently believed to be responsible for the ability of cranberry juice to prevent UTIs. Cranberry PACs can prevent the adherence of …
Structure, Synthesis And Biological Activity Of Harmful Algal Bloom Toxins From Karlodinium Sp. And Exploration Of Microbial Derived Natural Products, Amanda Leigh Waters
Structure, Synthesis And Biological Activity Of Harmful Algal Bloom Toxins From Karlodinium Sp. And Exploration Of Microbial Derived Natural Products, Amanda Leigh Waters
Electronic Theses and Dissertations
This work features natural products isolated from both the marine and microbial environments. Part I focuses on the elucidation of toxins from harmful algal blooms (HAB). The HAB dinoflagellate Karlodinium veneficum produces a harmful suite of molecules identified as the karlotoxins (KmTx) that have been implicated in massive fish kills pan-globally. Nine new karlotoxin congeners were isolated from various Karlodinium blooms around the world and utilizing the structure of KmTx2 were characterized using overlaid 2D NMR techniques. Due to the contrasting conformational differences between KmTx and the closely related amphidinols, the absolute configuration of KmTx was further evaluated by extensive …
Synthesis Of Resveratrol Ester Derivatives, Daniel Ressler
Synthesis Of Resveratrol Ester Derivatives, Daniel Ressler
Electronic Theses and Dissertations
The goal of this research project was to synthesize derivatives of transresveratrol. In order for resveratrol to be activated and used by the body it needs to bind to Human Serum Albumin (HSA), a protein in blood plasma. The derivatives were synthesized to improve the ability of resveratrol to enter cells as well as improve their ability to bind to HSA. The three derivatives that were synthesized have converted one of the hydroxyl groups on resveratrol to an ether with a methylene chain terminated by a carboxylic acid. By varying the lengths of the methylene chain we varied the water …
Tgf-B Signaling Pathway, Er-A And The Heterogeneity Of Breast Cancer Risk Among Hispanic And Non-Hispanic White Women., Stephanie Denkhoff Boone
Tgf-B Signaling Pathway, Er-A And The Heterogeneity Of Breast Cancer Risk Among Hispanic And Non-Hispanic White Women., Stephanie Denkhoff Boone
Electronic Theses and Dissertations
Many risk factors for breast cancer differ between race/ethnic groups. Few studies have included Hispanic women: a genetically admixed population that differs from other ethnic groups for breast cancer incidence, survival, and tumor phenotype. The objective of this study was to determine if genetic variation in ERa and TGF-ß signaling genes (TGF-ß1, TGF-ßR1, RUNX1, RUNX2, RUNX3) is associated with breast cancer risk, and if these associations differ between Hispanic and non-Hispanic white women (NHW). Data from The Breast Cancer Health Disparities (BCHD) study were used. BCHD is a multi-site consortium including two case-control studies within the U.S. and one in …
Techno-Economic And Fluid Dynamics Analysis For Growing Microalgae With The Intent Of Producing Biofuel Using A System Model, Leah R. Raffaeli
Techno-Economic And Fluid Dynamics Analysis For Growing Microalgae With The Intent Of Producing Biofuel Using A System Model, Leah R. Raffaeli
Electronic Theses and Dissertations
Techno-economic and systems studies on microalgal growth scenarios to date are abbreviated and missing a number of important variables. By including these variables in a detailed model integrating biology, chemistry, engineering, and financial aspects, a more defined systems analysis is possible. Through optimizing the model productivity based on the resulting net profit, the system analysis results in a more accurate assessment of environmental and economic sustainability of specific algal growth scenarios. Photobioreactor algal growth scenario optimization in the system model has resulted in realistic engineering design requirements based on algal growth requirements and fluid dynamics analysis. Results show feasibility for …
Ecology Of Glacial Relict Fishes In South Dakota's Sandhills Region, Eli Felts
Ecology Of Glacial Relict Fishes In South Dakota's Sandhills Region, Eli Felts
Electronic Theses and Dissertations
Native stream fish zoogeography has changed substantially across North America during the last century as habitat degradation, stream fragmentation and introductions of nonnative species have led to numerous extinctions, extirpations and altered distributions. Insufficient information regarding imperiled species often results in reactive, rather than proactive, management, and knowledge of species status and ecology is critical in identifying conservation priorities. South Dakota populations of three dace species (northern redbelly dace Chrosomus eos, finescale dace Chrosomus neogaeus, and pearl dace Margariscus margarita) are relict of Pleistocene Glaciation and are isolated from the northern core of their distribution, but little information exists regarding …
Method Development Using Laser Ablation And Solution Icpms And Their Application In Environmental Science And Forensic Provenance Studies, Kaixuan Bu
Electronic Theses and Dissertations
Inductively coupled plasma mass spectrometry (ICPMS) is an analytical technique that can be used to determine multiple elements and isotope ratios in a wide variety of samples. In this work, four projects are described that involve the method development using laser ablation (LA) and solution-based ICPMS and their application in environmental science and forensic (provenance) investigations. In the first project, plutonium (Pu) concentrations and 240Pu/ 239Pu atom ratios were measured in kelp, lichen, aquatic moss, and horse mussel collected on or near Amchitka Island, a former nuclear test in Alaska, and at a background site. The Pu in terrestrial and …
Investigation Of A Novel Magnesium And Acidified Ethanol System For The Degradation Of Persistent Organic Pollutants, Phillip Maloney
Investigation Of A Novel Magnesium And Acidified Ethanol System For The Degradation Of Persistent Organic Pollutants, Phillip Maloney
Electronic Theses and Dissertations
For centuries chemists have sought to improve humankind’s quality of life and address many of society’s most pressing needs through the development of chemical processes and synthesis of new compounds, often with phenomenal results. Unfortunately, there also are many examples where these chemicals have had unintended, detrimental consequences that are not apparent until years or decades after their initial use. There are numerous halogenated molecules in this category that are globally dispersed, resistant to natural degradation processes, bioaccumulative, and toxic to living organisms. Chemicals such as these are classified as persistent organic pollutants (POPs), and due to their negative environmental …
Biogeography And Systematics Of The Nerodia Clarkii/Nerodia Fasciata Clade In Florida, Gregory Territo
Biogeography And Systematics Of The Nerodia Clarkii/Nerodia Fasciata Clade In Florida, Gregory Territo
Electronic Theses and Dissertations
Biogeography provides a window into the evolutionary history of populations, and helps explain the diversity and distribution of life through time. Viewed from a systematic perspective, biogeographic studies generate convincing arguments to explain the relationships among organisms and categorize them into useful taxonomies. When taxonomies do not reflect evolutionary histories, inaccurate representations of biodiversity confound future studies and conservation efforts. Two thamnophiine snakes, Nerodia clarkii and Nerodia fasciata, harbor unique morphological and ecological adaptations that obscured natural groupings, leading to controversial taxonomic delimitations. Additionally, population declines documented in N. clarkii compressicauda and N. clarkii taeniata led managers to list N. …
The Dynamic Equilibrium Of Human Telomeric G-Quadruplexes., Robert Buscaglia
The Dynamic Equilibrium Of Human Telomeric G-Quadruplexes., Robert Buscaglia
Electronic Theses and Dissertations
G-quadruplexes are thought to have biological importance, with studies based on small molecule interactions and quadruplex-interactive antibodies demonstrating their potential for formation in vivo. One potential biological function of quadruplex structures is the regulation and maintenance of telomeres. Telomeres are nucleoprotein complexes involved in chromosome stability. Human telomeres are composed of the repeated DNA sequence, 5'- d(TIAGGG), that terminates in a 3' single-stranded overhang. DNA sequences with homology to the human telomere are capable of quadruplex formation in vitro. Specifically, sequences containing four-guanine stretches (e.g. 5'-d(AGGG(TIAGGGb)) are capable of forming at least five distinct unimolecular structures. Which structure is favored …
Advancing Global Tobacco Control: Exploring Worldwide Youth Attitudes And Behaviors Toward Tobacco Use And Control, Sreenivas Phanikumar Veeranki
Advancing Global Tobacco Control: Exploring Worldwide Youth Attitudes And Behaviors Toward Tobacco Use And Control, Sreenivas Phanikumar Veeranki
Electronic Theses and Dissertations
Tobacco use continues to be the leading cause of preventable death in the world. The disproportionate increase in tobacco use in low- and middle-income countries needs immediate attention. Many smokers begin smoking as adolescents and are most likely to become permanent smokers. Moreover, youth are highly targeted by tobacco industry strategies. However, a gap exists in literature to understand worldwide youth tobacco use and control. The purpose of this study is to 1) identify factors that influence never-smoking youths‟ smoking susceptibility, 2) explore characteristics that influence youth exposure to environmental tobacco smoke (ETS) and 3) to delineate key determinants of …
Cationic Aminooxy Lipids : Synthesis, Liposome Stabilization And Applications., Xuan Huang
Cationic Aminooxy Lipids : Synthesis, Liposome Stabilization And Applications., Xuan Huang
Electronic Theses and Dissertations
This dissertation describes research focused on the synthesis, polymerization and applications of cationic aminooxy lipids. An efficient and convenient method was developed to stabilize liposomes using 'click chemistry'. The 'click stabilized liposomes' are fortified via covalent crosslinks generated between aldehyde and aminooxy functionalities in the lipid bilayers. Compared to untreated liposomes (i.e., no lipid-lipid bonding), the 'click' stabilized liposomes are considerably more stable against surfactant-mediated liposome disruption or serum-mediated liposome aggregation. Stabilized liposomes also can react with 'clickable' targeted ligands on the liposome surface for specific organ (e.g. breast cancer cells or liver) targeting. In this thesis, I have explored …
Design, Synthesis, And Biological Evaluation Of Novel Polyamine Transport System Probes And Their Application To Human Cancers, Aaron Muth
Electronic Theses and Dissertations
The mammalian polyamine transport system (PTS) has been of interest due to its roles in cancer and maintaining cellular homeostasis. Polyamines are essential growth factors which are tightly controlled via a balance of biosynthesis, metabolism, import, and export. This work focused on the development and biological testing of polyamine transport probes to help understand the molecular requirements of the PTS. This was mediated through the use of a CHO (PTS active) and CHO-MG* (PTS deficient) screen, where compounds demonstrating high toxicity in CHO and low toxicity in CHO-MG* were considered PTS selective. The first chapter focused on the development of …
Phytochemical Studies On The Medicinal Plant Sutherlandia Frutescens, Xiang Fu
Phytochemical Studies On The Medicinal Plant Sutherlandia Frutescens, Xiang Fu
Electronic Theses and Dissertations
Sutherlandia frutescens (L.) R. Br (Fabaceae) is a multipurpose medicinal plant with diverse biological activities, and has been widely used for the treatment of cancer, AIDS, diabetes, and infectious diseases in southern Africa. The primary goal of this study was to investigate the chemical constituents of S. frutescens and develop an analytical method to analyze this plant and the dietary supplements derived from this plant. The dissertation is composed of six chapters. Chapter 1 introduces the general background of S. frutescens, including traditional uses and chemical and biological studies on the plant. Chapter 2 describes the phytochemical studies that have …
Isolation, Structure Elucidation And Biological Evaluation Of Natural Products From Plants And Fungi, Xiaoning Wang
Isolation, Structure Elucidation And Biological Evaluation Of Natural Products From Plants And Fungi, Xiaoning Wang
Electronic Theses and Dissertations
Natural products have provided considerable value for drug discovery over the past half-century. Nearly four fifth of drugs were natural products or inspired by natural compounds. Bioactive secondary metabolites isolated from natural source, either fungal or terrestrial, are relatively safer for human health and the environment and can serve as drug or as drug leads for the development of synthetic or semi-synthetic analogs. Natural products have also been successfully used in agriculture as plant growth regulators, signal transductions, fungicides, herbicides and tranquilizers. In our continued efforts to identify bioactive compounds, seventy-seven plant and fungal extracts were evaluated using a direct-bioautography …
Discovery Of Novel Glycogen Synthase Kinase-3beta Inhibitors: Molecular Modeling, Virtual Screening, And Biological Evaluation, Gang Fu
Electronic Theses and Dissertations
Glycogen synthase kinase-3 (GSK-3) is a multifunctional serine/threonine protein kinase which is engaged in a variety of signaling pathways, regulating a wide range of cellular processes. Due to its distinct regulation mechanism and unique substrate specificity in the molecular pathogenesis of human diseases, GSK-3 is one of the most attractive therapeutic targets for the unmet treatment of pathologies, including type-II diabetes, cancers, inflammation, and neurodegenerative disease. Recent advances in drug discovery targeting GSK-3 involved extensive computational modeling techniques. Both ligand/structure-based approaches have been well explored to design ATP-competitive inhibitors. Molecular modeling plus dynamics simulations can provide insight into the protein-substrate …
Biochemical Studies Of Abce1, Lynn Sims
Biochemical Studies Of Abce1, Lynn Sims
Electronic Theses and Dissertations
The growth and survival of all cells require functional ribosomes that are capable of protein synthesis. The disruption of the steps required for the function of ribosomes represents a potential future target for pharmacological anti-cancer therapy. ABCE1 is an essential Fe-S protein involved in ribosomal function and is vital for protein synthesis and cell survival. Thus, ABCE1 is potentially a great therapeutic target for cancer treatment. Previously, cell biological, genetic, and structural studies uncovered the general importance of ABCE1, although the exact function of the Fe-S clusters was previously unclear, only a simple structural role was suggested. Additionally, due to …