Digital Commons Network^™

James S. Allen And Communist Organization Of The Depression South In The 1930s, Jonathan Dale Harwood

Electronic Theses and Dissertations

This thesis examines the methods and means by which the Communist Party of theUnited States organized in the US South during the 1930s. With a focus on the “Negro Question”, I hope to show that local, rather than national or international, concerns animated CPUSA organizing. To that end, the records of James S. Allen, a key CPUSA theoretician, are used to explore the relationships between local Southern sub-organizations and the CPUSA leadership. His organizing in the South is crucial to the avenues that Communists organized and utilized his writings to shape Party policy and engagement with African Americans of the …

The Hollidays In Mississippi: A Documentary Project About Queer Family, Legacy, And Community Struggle, Christina Alison Huff

Electronic Theses and Dissertations

This MFA thesis accompanies a short documentary film encompassing a “passing of the torch” story between Eric White (GoDiva Holliday) and his drag daughter, Justin Tyler (DeePression Holliday.) After twenty years of performing and directing drag shows in Tupelo, MS, White makes the decision to let go of his passion and focus on himself. He ensures that his drag daughter, Holbrook, carries on the legacy of creating LGTBQ spaces in the conservative South. This story will also touch on the familial relationship between the two drag performers who both grew up in small-town Mississippi but in different eras. The work …

Effect Of Excipients/Solvents On The Barrier Integrity And Topical Drug Delivery Across Micropores, Abhishek Shettar

Electronic Theses and Dissertations

The topical and transdermal drug delivery system offers several advantages over conventional drug delivery; non-invasive, patient compliance, avoidance of first-pass metabolism, and sustaining therapeutic drug levels for several days. As a route for drug administration, skin presents a large surface area and can be used for both local and systemic drug delivery. However, the skin forms a formidable barrier protecting the human body from external environmental rigors and excessive water loss, maintaining equilibrium. The skin's barrier properties can be attributed to its unique macromolecular organization and morphology. However, the organized structure of the skin, since intended to prevent the entry …

Optimizing Exposure For Contamination Ocd: What Happens When Digust Is Specifically Targeted?, Molly E. Wickenhauser

Electronic Theses and Dissertations

Disgust is a basic emotion with distinct subjective, physiological, cognitive, and behavioral processes that include revulsion, parasympathetic nervous system activity, contamination-specific appraisals, and disease-avoidance behaviors. Pathological disgust responses may contribute to the development and maintenance of anxiety-related psychopathology, particularly spider and blood-injection-injury phobias, health anxiety, post-traumatic stress disorder, and obsessive-compulsive disorder (OCD). Evidence-based treatments for these disorders were developed based on theories of fear and anxiety and involve exposure-based cognitive-behavior therapy. However, traditional exposure methods appear to be less effective at achieving habituation to disgust compared to fear and anxiety. Additionally, individuals with elevated disgust and primary contagion concerns seem …

Look, But Don’T Touch: Impact Of Covid-19 On The Nicu Caregiver, Rebecca C. Otwell-Dove

Electronic Theses and Dissertations

Admission of an infant into the neonatal intensive care unit (NICU) is an experience that has been associated with a variety of both positive and negative health outcomes for parent and child. While both the setting name and the admitted population alludes to a sole focus on the affected infant, what often remains underrecognized is the impact on the ones who care for the newborn long before and longer after their NICU stay. Given the recency and unprecedented impact of the COVID-19 pandemic, very little research has examined the impact of COVID-19-specific stress on the experience of parents of infants …

Evaluating Bat Roost Abundance: A Comparison Of Drone-Acquired Thermal Imagery And Acoustic Estimates With Visual Observations, Karah Jaffe

Electronic Theses and Dissertations

Roosts provide an opportunity to census philopatric populations of bats. Comparing the efficacy of traditional methods with novel methods can provide guidance on the use of new technologies in the field. This project aims to compare the count efficacy of external emergence methodologies, i.e., drone-acquired thermal imagery, acoustic estimates, and visual counts. Surveys were conducted ten nights at two emergence sites and synchronized to compare counts. Acoustic estimates could not be established as there was a weak prediction of the linear relationship between root-mean-square pressure and emergence count; therefore, this method was removed from the comparative analysis. A linear mixed-effects …

Validation Of The 40 Hz Auditory Steady State Response As A Pharmacodynamic Biomarker Of Evoked Neural Synchrony, Muhammad Ummear Raza

Electronic Theses and Dissertations

Schizophrenia is a troubling and severe mental illness that is only incompletely treated by currently available drugs. New drug development is hindered by a scarcity of functionally relevant pharmacodynamic biomarkers that are translatable across preclinical and human subjects. Although psychosis is a major feature of schizophrenia, cognitive and negative symptoms determine the long-term functional outcomes for patients. Stimulus-evoked neural synchrony at gamma (~ 40 Hz) frequency plays an important role in the processing and integration of sensory information. Not surprisingly, schizophrenia patients show deficits in gamma oscillations. NMDA receptor (NMDAR) activation on fast-spiking parvalbumin-positive interneurons is deemed important for the …

Occupational Health Assessment Of Tomato Farmworkers In East Tennessee, Mercy E. Aula

Electronic Theses and Dissertations

Farmworkers play an integral role in the production and availability of tomato fruit for consumption. Yet the work activities of farmworkers present risk factors for musculoskeletal disorders. Tasks involving stake pounding, picking, bucket toss, and trellising entail risk factors such as repetitive motions, lifting/carrying of heavy loads, and working in flexed trunk postures. These physically demanding activities are typically associated with musculoskeletal disorders (MSDs). Presently, quantitative assessments of these jobs and health risks to the workers are rare. Access to the workers who are often migrant and seasonal can pose an impediment to such investigations. This research examines three tasks …

The Paleoecology Of High-Elevation Bison In The Greater Yellowstone Ecosystem And Implications For Modern Bison Conservation, Darian Bouvier

Electronic Theses and Dissertations

The national mammal of the United States, the American Bison (Bison bison) was once nearly extinct. Populations have recovered to the degree that thousands roam the Great Plains today. Due to their large numbers and body size, this species has an oversized impact on the ecological communities where it lives and is considered a keystone herbivore in modern North American grasslands. This study explores the detailed, seasonally resolved, paleoecology of seven bison from the Greater Yellowstone Ecosystem during the Late Holocene through stable isotope analyses and species niche modeling. Isotopic analyses of δ¹³C, δ¹⁵N, …

Cyclic Di-Gmp Regulates Motility, Biofilm Formation, And Desiccation Tolerance In Acinetobacter Baumannii, Garrett Reynolds

Electronic Theses and Dissertations

Acinetobacter baumannii is an increasingly multidrug-resistant pathogen contributing to hospital-acquired infections necessitating the discovery of novel treatments. A bacterial second messenger, cyclic diguanosine monophosphate (cyclic di-GMP), can regulate various persistence factors that are potentially advantageous for survival in hospital environments. Cyclic di-GMP–modulating enzymes and cyclic di-GMP–binding effectors predictively are encoded in the Acinetobacter baumannii genome. I hypothesized that cyclic di-GMP controls motility, biofilm formation, and desiccation tolerance in Acinetobacter baumannii. Disrupting cyclic di-GMP–modulating enzymes or cyclic di-GMP–binding effectors should alter the regulatory effectiveness of these phenotypes. I tested the multidrug-resistant isolate Acinetobacter baumannii strain AB5075 and identified several transposon …

Dibutyl Amine Detection, Quantification, And Removal With Iron(Ii)Tetrasulfophthalocyanine (Fetspc), Kyle Bittner

Electronic Theses and Dissertations

Pesticide testing is of practical interest in various areas of today’s world due to their prevalence and toxicity. These areas include agriculture, environmental, chemical plants, and many others. Herbicides, like Roundup, contain secondary amines such as glyphosate. The ability to detect secondary amines could offer a method for glyphosate detection in agricultural and environmental samples. Secondary amines can interact with metal complexes through electron charge transfer. Such interactions can cause a change in the metal’s electron configuration and energy state and can be seen in the UV-Vis spectrum. Metal phthalocyanines (MPc’s) and other organometallic complexes have been of interest for …

Effects Of Excessive Soil Phosphorus Accumulation On Loblolly Pine (Pinus Taeda L.) Seedlings, Hannah C. Bays

Electronic Theses and Dissertations

Many landowners in East Texas apply poultry litter to pastures as a source of nitrogen (N) for forage crops. After many years of repeated poultry litter application, soils can accumulate extremely high extractable phosphorus (P) concentrations, sometimes over 1000 mg kg^-1 of plant available P. Landowners report the conversion of these pastures to loblolly pine (Pinus taeda L.) plantations is often problematic, with poor seedling survival and abnormal tree growth. This study was conducted to assess the effects of excessive soil phosphorus on loblolly pine seedlings. An outdoor pot study was conducted using bare root seedlings and triple …

Soil Quality Indicators And Vegetation Responses Following Ecological Restoration Thinning Of Ponderosa Pine On Three Soil Parent Material Types Under Grazing And Non-Grazing In Northern Arizona, Christopher Macdonald

Electronic Theses and Dissertations

This research was performed in a northern Arizona ponderosa pine (Pinus ponderosa P. & C., Lawson) forest. The objectives were to a) increase understanding of long-term vegetation responses to ecological restoration treatments on three soils types, with and without grazing, b) evaluate the responses soil physical, chemical, and biological properties to restoration treatments, with and without grazing, c) determine the utility of measured soil quality indicators to informing risks to sustainable soils management in southwestern ponderosa pine forests.

There were no significant differences in soil bulk density by soil type, treatment type, or grazing treatment. No significant differences …

Development Of Anti-Inflammatory Theranostic Nanocolloids Using Quality By Design Approaches, Michele Herneisey

Electronic Theses and Dissertations

Nanocolloids are attractive delivery vehicles for drugs with poor aqueous solubility. Despite this, relatively few nanocolloid products exist on the market. Currently, there is a lack of standardization in the pre-clinical, academic setting regarding nanocolloid development and quality control testing. Adaptation of quality by design (QbD) methods used in the pharmaceutical industry to nanocolloid development is a desirable approach that can improve nanocolloid product and process understanding, resulting in an increased number of marketable products.

The central hypothesis of this work is that QbD approaches can be utilized to optimize theranostic (therapeutic and diagnostic) nanocolloid stability, drug loading, and imaging …

A Bioaffinity Self-Assembling Gel For Localized Delivery Of Immunotherapeutics, Ngoc Pham

Electronic Theses and Dissertations

Renal cell carcinoma (RCC) is a type of cancer in which malignant cells develop in the kidney tubules. Immune checkpoint inhibitors (ICI), including anti-PD-1 antibodies (aPD1), as monotherapies or in combination settings have advanced to the front-line treatment for patients diagnosed with RCC. Systemic infusion of ICI may render subtherapeutic concentrations in the lesions and increase risks of immune-related adverse events. To overcome these limitations, locoregional drug delivery has gained substantial interests as a modality in immuno-oncology. However, conventional intratumoral injections may be ineffective because the high interstitial fluid pressure in tumors resists drug retention and results in rapid local …

Sex-Specific Effects Of Chaperone And Glial Defenses On Experimental Lewy Body Disease, Tarun Bhatia

Electronic Theses and Dissertations

Lewy body disorders are a group of neurodegenerative conditions characterized by the pathological misfolding and aggregation of the abundant protein, α-synuclein. The most common Lewy body disorders are Parkinson’s disease and dementia with Lewy bodies. Apart from ageing, male sex is a major risk factor for Lewy body disorders, as men are at ~1.5-fold higher risk for these diseases than women. Yet, preclinical studies on Lewy body disorders rarely examine sex as a biological variable, and the mechanisms underlying sex-skewedness in disease risk remain undetermined.

Here, we developed a sex-stratified model of Lewy body disorders by exposing primary neurons harvested …

Loggerhead Shrike Detectability And Occurrence In Coastal South Carolina Urban Areas, Michelle Krauser

Electronic Theses and Dissertations

Grassland birds, such as the loggerhead shrike (Lanius ludovicianus), are threatened by extensive land-use change, including urbanization. Loggerhead shrikes have been declining since the early 1900s and are rare or extirpated in portions of their former range. Obtaining reliable population estimates of loggerhead shrikes is important to identify demographic trends and ensure conservation decisions are based on an accurate assessment of their current status. Imperfect detection, or the inability to detect every shrike during a survey, can result in biased population estimates. Estimating detection probability is labor-intensive and requires assumptions that are difficult to satisfy in most field studies. Understanding …

Enzootic Trends Of Crassostrea Virginica And Perkinsus Marinus In North Inlet Estuary, South Carolina, Nico Martin D'Amico

Electronic Theses and Dissertations

The Eastern oyster (Crassostrea virginica) co-occurs with the protozoan parasite Perkinsus marinus (the causative agent for "Dermo") in US Atlantic and Gulf of Mexico estuaries. Oyster host functions as an ecological engineer and agent for benthic-pelagic coupling are compromised when P. marinus infections are common in populations (prevalence) and high in individuals (intensity). P. marinus infections in oysters from North Inlet estuary, South Carolina were quantified in relation to shell height (60-76 mm, ≥76 mm), sex (functional female, male, indeterminate), water temperature, and salinity. Three fringing reefs on a longitudinal transect from the inlet mouth into the watershed were sampled …

Winter Use Of Winyah Bay, Sc By The Spiny Dogfish (Squalus Acanthias), And Their Movements South Of Cape Hatteras, Nc, Meredith L. Langford

Electronic Theses and Dissertations

South of Cape Hatteras, NC, little is known about the coastal distribution and movement of the Spiny Dogfish, Squalus acanthias. Between January 2018 and March 2020 this study conducted winter demersal longline sampling in Winyah Bay, SC to investigate habitat use by Spiny Dogfish. In addition to monitoring Winyah Bay use through catch-and-release, 13 individuals were outfitted with implanted Vemco™ acoustic transmitters to monitor large scale movements along the U.S. East Coast. Across three sampling seasons 84 female Spiny Dogfish were captured within lower Winyah Bay. No males were observed over the course of the study. The mean fork length …

Evaluating Threats To The Water Quality Of Little Buffalo Creek And Sarver Run Through Water Quality Analysis And Backpack Electrofishing Surveys, Riley Williams

Electronic Theses and Dissertations

Currently, 64.8% and 52.2% of Little Buffalo Creek and Sarver Run stream kilometers are impaired, respectively. Impairment sources to Little Buffalo Creek include agriculture, riparian deforestation, on-site wastewater, and urban runoff. Impairment sources to Sarver Run are unknown. Our goal was to understand sources of impairment through water quality analysis and fish surveys. Water samples were collected monthly and analyzed for cation and anion concentrations. Mass ratio analysis comparing Br/SO₄ and Mg/Li, Ca/Mg and Ca/Sr, Mg/Na and SO₄/Cl, and SO_4/Cl and Mg/Li suggests that mine drainage and conventional oil and gas may be impacting water …

Steps Toward The Total Synthesis Of The Chrysosporazine Family, Katie Kaczynski

Electronic Theses and Dissertations

Cancer is one of the leading causes of death worldwide, with 19.3 million new cancer cases and 10 million deaths in 2020 alone. In the United States, cancer was the second leading cause of death after heart disease. One of the reasons that cancer is so frequently terminal is that cancerous cells frequently develop multidrug resistance (MDR) to frontline chemotherapeutical treatments, resulting in cancers cannot be treated and are inevitably fatal. This makes the discovery of ways to combat MDR so important in the treatment of cancer. The chrysosporazines are a family of recently discovered (2019) natural products that have …

A Review Of Current Methods In Avian Dietary Analysis And Their Integrated Application To Characterize The Trophic Niche Of Louisiana Waterthrush (Parkesia Motacilla)., Brandon Hoenig

Electronic Theses and Dissertations

Characterizing a species’ dietary composition presents an avenue to understand many facets of its ecological niche and can provide essential information for the species’ long-term conservation. To date, the vast majority of diet studies have relied on direct identification of prey during foraging observations or from diet samples to characterize the dietary habits of birds. However, advancements in laboratory-based approaches have revolutionized the field of trophic ecology by allowing researchers to indirectly infer dietary habits with higher resolution across greater time scales. Here, I apply two of these laboratory-based techniques, namely DNA metabarcoding and stable isotope analysis, to characterize the …

Evaluation And Application Of Crispr-Cas12a-Based Systems For Amphibian Detection From Dietary And Environmental Dna, Macie Chess

Electronic Theses and Dissertations

Current methods for monitoring biodiversity are hindered by detection efficiencies or rely on expensive laboratory equipment. The goal of this study was to evaluate the application of a CRISPR-Cas12a-based system for the species-specific detection of amphibians from dietary and environmental DNA samples. A Cas-12a-based platform was designed and analyzed for the fluorescent detection of three salamander species; Desmognathus fuscus, D. ochropheaus, and Erycia bislineata. This system was applied to the identification of salamander DNA extracted from the fecal sacs of nestling Louisiana Waterthrush (Parkesia monticola), amplified with PCR primers targeting the CYT B mtDNA gene, and compared to DNA metabarcoding. …

Rooted In The Earth: An Igbo Sacramental Nature Of The Universe, A Model For Igbo Christian Ecological Ethics, Kenneth Oguzie

Electronic Theses and Dissertations

The contemporary Igbo society faces a lot of challenges. These include political, religious, and moral crises. These crises affect the environment in many ways. They threaten the peace and harmony of the Igbo society. As a result, it touches on faith. The Igbo society holds a holistic view of life. Whatever affects one aspect of life affects the other areas. Ecologically, various factors are responsible for the crises. These include changes in lifestyle from the traditional way of living to modern style of life with its penchant on consumerism. Also, colonialism and its lingering residues, civil unrests, politics, population growth, …

Cultural Trauma Fiction: Political Violence, Rampage Violence, And Structural Violence In Contemporary American Literature, Courtney Mullis

Electronic Theses and Dissertations

This dissertation identifies and proposes a new subgenre of American literature, Cultural Trauma Fiction, that has arisen since the late 20^th century in response to numerous large-scale traumatic events and their representation in the media. Cultural trauma occurs when a shocking, shared event fractures collective identity and initiates a discursive process to understand what took place, why it happened, and how the affected culture can heal. Cultural traumas differ from individual trauma because cultural traumas affect a culture, rather than an individual, and because they are mediated; many members of the culture experience the trauma of these events secondhand …

Biomaterials: From Scaffold Design To Implant Optimization, Jennifer Marie Armen

Electronic Theses and Dissertations

This work encompasses three individual projects concerning biomaterials and their modifications. Chemically-Induced Cross-Linking of Peptidic Fibrils for Scaffolding Polymeric Particles and Macrophages EAK16-II (EAK) is a self-assembling peptide (SAP) that forms β-sheets and βfibrils through ionic-complementary interactions at physiological ionic strengths. The soft materials can be injected in vivo, creating depots of drugs and cells for rendering pharmacological and biological actions. The scope of the applications of EAK is sought to extend to tissues through which the flow of extracellular fluid tends to be limited. In such anatomical locales the rate and extent of the fibrilization are limited insofar as …

Isocrates's Place In Postmodern Advertising, Christopher Barkley

Electronic Theses and Dissertations

This study in communication and rhetoric seeks to ascertain constructive applications for distinct advertising practices by examining Isocrates’s work and place in postmodern advertising. The focus uses 5 principles known to Isocrates which are: 1) commonwealths of households, 2) integration of reputation, elegance, substance and style, 3) education and public discourse, 4) phronesis and praxis, and 5) truth and verisimilitude. These 5 principles can form a constructive and practical advertising approach. This study is important. It examines Isocrates through the lens of advertising and extends the research done about him by leading Isocrates scholars who have looked primarily at his …

A Bioethics Critique Of The Healthcare System In Nigeria: Personal Dignity And Human Solidarity, Cyprian Duru

Electronic Theses and Dissertations

Life is a sacred gift, an indivisible good with an inherent dignity and value. Despite its uniqueness, fragility, vulnerability, and limitations, it remains the most interesting, attractive, and exciting thing one can possess. These attributes invoke a deep sense of respect to life. Recently, science and biotechnology have astonished the world, as they continue to disorient human consciousness on new set of ethical issues. In effect, life is seriously exposed to the perspectives of modern science and technology. Thus, President George W. Bush warns that the powers of science are morally neutral, capable for good and bad purposes. In …

C-H On The Oxo Ferryl Wheel: Comparison Of Pyridine And Imidazole-Substituted Ligands For C-H Activation And Functionalization, Elizabeth Milem

Electronic Theses and Dissertations

The selective and efficient transformation of hydrocarbon feedstocks is of high value for industry and research. While Shilov-type organometallic methods have facilitated this goal, systems designed after nature’s use of cheap and abundant iron-based enzymes are desired for wider-scale applications. This work establishes hydrocarbon oxidation efficiency of synthetic pyridine-based ligands (BPMEN, BPMPN) compared to commercially available TPA with in situ generated catalysts. Literature studies of traditionally synthesized BPMEN systems and initial in situ studies offered evidence for enhanced reactivity (TON) as compared to TPA. Expansion to a propyl backbone to produce BPMPN tested the increased chelate ring size’s impact on …

Detection, Occupancy, Abundance, And Mercury Accumulation Of The Alligator Snapping Turtle (Macrochelys Temminckii) In Texas, David Rosenbaum

Electronic Theses and Dissertations

Land use practices and physical alterations of ecosystems result in habitat loss and fragmentation, while chemical alterations, such as pollutant input, reduce habitat quality and health of exposed organisms. Here, I investigated the effects of watershed- and local-scale environmental variables on the occupancy, abundance, and mercury accumulation of a threatened aquatic species (Macrochelys temminckii, i.e., alligator snapping turtle) within the southwestern periphery of its distribution. Hierarchical modeling suggested the distribution of the species is more affected by watershed-scale land-cover than local habitat, and provided a baseline estimate of average species abundance across its range in eastern Texas. Abundance …