Digital Commons Network^™

A Solid Phase Assay For Topoisomerase I Interfacial Poisons And Catalytic Inhibitors, Vidusha Cyril

Electronic Theses and Dissertations

We report a mechanism based screening technique to rapidly identify eukaryotic topoisomerase I targeting agents. The method is based on genetic tagging of topoisomerase I to immobilize the enzyme on a solid surface in a microtiter well format. DNA is added to the wells and retained DNA is detected by Picogreen fluorescence. Compounds that result in an increase in Picogreen staining represent potential topoisomerase interfacial poisons while those that reduce fluorescence report catalytic inhibitors; therefore, the solid phase assay represents a „bimodal‟ readout that reveals mechanisms of action. The method has been demonstrated to work with known interfacial poisons and …

Fish From Afar Marine Resource Use At Caracol, Belize, Smith Petra Cunningham

Electronic Theses and Dissertations

The ancient Maya had strong ties to the sea. The trade, transportation and use of marine resources were important not only to coastal Maya communities, but also to the heavily populated cities that lay many miles inland. A review of zooarchaeological evidence recovered from excavations at the inland site of Caracol, Belize suggests that the inhabitants imported marine fish for food, marine shell for working into trade items, and sharks teeth and stingray spines for ritual use. This thesis examines the manner in which fish and other marine resources were used, procured and transported from the coast to the site …

Beyond The Battlefield, Gary A. Seymour

Electronic Theses and Dissertations

I am exhibiting several drawings, paintings, and sculptures representing a visual record of my creative research into, and my handling of, snails. Although I depict snails and their environment in a loose representational style, I have begun to incorporate digital drawing to enhance my art in a mixed media approach. I have created illustrative images of a forest floor as I imagine it would look to a snail in a giant, menacing world. Close-up images of grass become unusual jungle scenes, and my once tiny snails achieve a measure of control in this fanciful world. The inspiration for my art …

Identification Of Factors Influencing The Commission Of Burglaries, Mustafa Donmez

Electronic Theses and Dissertations

As in many countries, burglary is a very serious crime in Turkey. Scientific methods and techniques are needed to solve complex burglary cases. This study is completed in the Bursa Police context since they classified many crime data conducive to scientific studies under a project called BEMTAP. The main purpose of this study is to examine the factors influencing the commission of burglaries, using an epid-criminological perspective. It can be argued that factors leading to the commission of a crime are important for formulating preventive strategies in the community. In this study, the contributing factors are categorized into three main …

Molecular Analyses Of Changes Induced In The Microbial Populations Of Murine Colon After As(Iii) Exposure, Rishu Dheer

Electronic Theses and Dissertations

The gut microbiota is essential for mammalian health and metabolism. Thus identifying factors that influence the host microbiota is key to understanding the dynamic interplay between the host and its microbiota. Recent studies have shown the effect of chronic exposures of trivalent arsenic [As(III)] in environmentally relevant concentrations on host physiology, however, little is known of how it impacts the gut microbiota.

This study examined the hypothesis that environmentally relevant concentrations of As(III) in drinking water will directly affect the murine colon microbial composition and physiology. The colon microbial communities from 10 and 250 ppb of As(III) exposed mice were …

Making Visual Noise, Deborah Starr Leitch

Electronic Theses and Dissertations

Focusing on the combination of multi-cultural and historical influences from my personal life experiences, my creations of odd juxtapositions of space, complex pattern and new iconography in my paintings, reveal more than merely a representational image to a viewer. Although my subjects may vary from the anonymous to media celebrity, it is their relationship to me that influences the creation of my static animation and visual noise.

An Evaluation Study Of The Effectiveness Of Using A Reaction-Based Process For Hydrazine Waste Remediation, Cristina M. Oropeza

Electronic Theses and Dissertations

Hydrazine (HZ) and monomethylhydrazine (MMH) are used extensively as hypergolic propellants at Kennedy Space Center. These highly reactive fuels are considered highly toxic, and potentially carcinogenic. Consequently, the transport, handling, and disposal of hydrazines is strictly regulated to protect personnel and the environment. Currently, KSC generates large volumes of hydrazine-laden wastewater for disposal. This waste is contained and shipped on public highways for subsequent disposal by incineration presenting a potentially catastrophic threat to the environment and the general public in the event of an accidental release. Other existing remediation methods include oxidative and reductive pathways as well as biodegradation in …

Gore's Science The Kairos Of An Inconvenient Truth And The Implications For Science Writing, Carolyn M. Glasshoff

Electronic Theses and Dissertations

Modern Americans are exposed to scientific and technical information on a daily basis that urges them to react as well as learn about new ideas. The popular science writing that circulates this information must be portrayed in a way that makes it easy for lay people to understand complicated ideas while at the same time remaining complex enough to convince readers that the information is reliable, accurate, and worth learning. In making decisions about how to accomplish this balancing act, science writers make decisions that influence the audience's opinion about new scientific ideas, how easily the audience will accept or …

Ambivalent Sovereignty: Inquiries Into The Dual Foundation Of Political Realism's Subject, Paul Timmermans

Electronic Theses and Dissertations

Ambivalent Sovereignty inquires into the subject of political realism. This subject, sovereign authority, appears to have a dual foundation. It appears divided against itself, but how can realism nonetheless observe legitimate modes of sovereignty emerge? Against the liberal idea that a "synthesis" of both material-coercive and ideal-persuasive powers should be accomplished, within the world of international relations, realism gives meaning to a structural type of state power that is also constitutionally and legitimately dividing itself--against itself. Machiavelli but particularly also other realists such as Hannah Arendt, Max Weber, and Aristotle are being reinterpreted to demonstrate why each state's ultimate authority …

The Intricacies Of M.F.K. Fisher: Discovering A Kaleidoscopic Hybridity, Elizabeth Lee Sleeper

Electronic Theses and Dissertations

This thesis seeks to analyze M.F.K. Fisher's socio-historic role and the components of her texts as a means to interrogate the categorization of her writing, to identify her authorial voice, and to see how it all contributes to and proves that Fisher is a `kaleidoscopic' hybrid writer. I utilize theoretical positions such as New Historicism, Feminism, Genre Theory, and Everyday Theory to help me identify and explain the hybrid tendencies of Fisher's writing. It is not a comprehensive study of her texts in light of these theories, but rather, it is a broad overview in order to demonstrate alternative readings …

Realizing Sustained School Improvement, Jeanice Kerr Swift

Electronic Theses and Dissertations

Developing effective methods for improving America's schools is dependent upon coordinated work of practitioners and researchers. School improvement proves a complicated, confusing and most often troubled process; one characterized by the unprecedented challenges of dramatic societal shift, increasing levels of student need, and ongoing involvement from political and governmental influences. The drive to discover better ways to consistently improve schools is fueled by urgency for dramatic results.

This research examines both the macro and the micro levels of the school improvement process and illuminates the need for an intentional new way of thinking and leading. At the macro level, the …

Interpersonal Trauma, Posttraumatic Stress And Depression, Brennan J. Young

Electronic Theses and Dissertations

Dating aggression is common among emerging adults, and women who experience aggression from a dating partner are at risk for elevated depression and posttraumatic stress (Dutton et al., 2006). Although some women end their relationships as a result of aggression, other women remain committed to their partner, and aggression tends to escalate over time. The current study explored the role that depression and posttraumatic stress play in ending aggressive dating relationships as well as changes in these symptoms after ending such a relationship. The current study also sought to identify factors predictive of individual differences in emerging adults' commitment to …

Intuitive Virtue In Plato, Augustine, And Gandhi, Brian Timothy Keady

Electronic Theses and Dissertations

In this study, I argue that Plato, Augustine, and Gandhi hold in common the view that (1) in order to develop understanding of ultimate reality one must--in addition to engaging in contemplation of that reality--engage ethically in the practical world, and (2) in order to engage ethically in the practical world, one must also seek to understand ultimate reality through contemplation.

Much of what is original in the dissertation emerges at the level of the sub-theses I present in support of these ideas. I examine (1) and (2) in Plato by offering a reinterpretation of his conception of dialectic--the practice …

Trick Rider, Jen Tynes

Electronic Theses and Dissertations

Trick Rider is a book-length poem in four sections, which uses characteristics of the epic and gothic, as well as strategies of chance operations, to explore the compositional process in relation to time, how time is experienced during the writing process and is communicated through the text as an object and through the process of reading. The polyphonic speaker of Trick Rider is a stunt double and experiences doubling, being both representative of and an outsider to the community she channels; this tension is simultaneously cause and effect of the text.

Macroeconomics After The Great Recession: Consensus Or Conflict?, Hailiang Xu

Electronic Theses and Dissertations

Unlike microeconomics where there are relatively few disagreements, the field of macroeconomics has always been the arena of several competing theories. Despite that history of conflict, in the late 1980s during the Great Moderation, the New Classicals and the New Keynesians reached an agreement, known as the New Consensus during the Great Moderation. For decades, the New Consensus has dominated macroeconomic theory and policymaking not only in the U.S., but also throughout the world. After many years of calm, however, the 2007-2008 subprime mortgage crisis and its consequent Great Recession demonstrated that how fragile that consensus was.

While the debate …

Hepatitis C Virus-Induced Hepatocellular Carcinoma: Cancer Stem Cell And Gene Therapy, Heba Samir Esmaeil Allam

Electronic Theses and Dissertations

Hepatitis C virus (HCV) is an important human pathogen that causes chronic hepatitis cirrhosis, steatosis and hepatocellular carcinoma (HCC) worldwide. Although current FDA-approved drugs are partially effective in the treatment of HCV, methods for cure and vaccine against the virus are still awaited. My thesis work presented here is focused on finding mechanism (s) of HCV-induced hepatocarcinogenesis and devising novel means to combat the HCV infection.

Herein, we have shown that long-term HCV expression results in the acquisition of cancer stem-like cells (CSCs) traits in liver derived cell lines. These traits include enhanced expression of putative stem cell markers DCAMKL-1, …

Discovering Border Crossings In Pagan Epic Literature, Marian Russell Bland

Electronic Theses and Dissertations

This dissertation argues that border crossings were important to the ancient Celts and Norse as evidenced by the vast quantity of occurrences in their literature,and have remained important themes in literature throughout the ages. Border crossings reflect man's fascination with concepts beyond his immediate existence and understanding. His reactions to such inexplicable phenomena have provided inspiration to writers for hundreds of years. The investigation uncovers examples of border crossings in the epic stories captured in the Ulster and Fenian Cycles, TheTáin, The Eddas, and The Mabinogion.

Border crossings remain important for modern literary scholars to consider …

Porting Transmedia Storytelling To Journalism, Kevin Timothy Moloney

Electronic Theses and Dissertations

This thesis examines how the methods of transmedia storytelling emerging in the entertainment industry might be used in a journalism context. Journalism is facing many crises, not the least of which is a loss of readership and perceived relevance to its public. Presented with an ever-expanding array of media with which to interact, the public is more difficult to attract to a socially relevant issue or a politically important story. Faced with similar issues, the entertainment industry has developed a means to engage with fans in a way that draws them across multiple media platforms, better captures their imagination and …

Kids And Kingdom: The Precarious Presence Of Children In The Synoptic Gospels, Arthur James Murphy

Electronic Theses and Dissertations

At a time when institutions of faith are increasingly confronted with scandals that have brought the vulnerability of young children to the fore of religious consciousness, some scholars have pointed to Jesus' special concern and affection for children in the Gospels. Scholars are struck by how often the authors place Jesus in relation to children: healing them, blessing them, and challenging their marginal status by characterizing them as models for understanding the kingdom of God proclaimed by Jesus. If the authors had concluded their stories of Jesus' eschatological gathering with the blessing of the children, then their characterizations of children …

The Social Determinants Of Hiv/Aids In Cambodia: Is It Too Early To Call Micro Medical Efforts A Success?, Matthew Aaron Sherwood

Electronic Theses and Dissertations

Cambodia, a least developed country (LDC) with a recent history of civil war and genocide, has been widely considered to be a success story when it comes to the fight against HIV/AIDS. Within a few years of the first HIV positive blood test in the kingdom in 1991, it quickly became the country with the highest prevalence in the region, with estimates of as many as 4% of the population being infected at one point.

In recent years, Cambodia's HIV/AIDS infection rates have plummeted to below 1%, with most of the credit being given to the implementation of micro-medical measures, …

I Thought You Were Someone Else, Maria Milazzo

Electronic Theses and Dissertations

I Thought You Were Someone Else deals with violence, family, love, art, and gender. The author examines these issues as well as what makes a creative work fiction or nonfiction by creating a multi-genre collection of seven short fiction stories and five short nonfiction pieces. Fictional stories feature protagonists similar to the author and protagonists who could be considered completely different from the author. Nevertheless, the protagonists in these pieces, whether they are real or fictitious, all experience grand realizations concerning their identity and surroundings. Essentially, they realize they are not who they thought they were. A young boy realizes …

By Any Means Necessary: The Quandary The Cia Now Faces In Light Of Employing Enhanced Interrogation Methods To Combat The War On Terror, Joshua Laufer

Electronic Theses and Dissertations

The outcry of torture being used during CIA interrogations of enemy combatants at Guantanamo Bay and other sites certainly jolted international humanitarians. With modern warfare evolving towards unconventional warfare, the notion of interrogation has become more controversial and linked hand-in-hand with torture methods. This study is not trying to make a case for torture, but instead seeks to provide qualitative reasoning through primary and secondary sources which some seek to support enhanced interrogation.

It will be important to identify why enhanced interrogation techniques are effective and deemed essential by some. If certain enhanced methods create extreme physical and emotional duress, …

A Communication Approach To Understanding Rapid Responses To Others: The Importance Of Flexibility Across Goal Conditions, Betsy App

Electronic Theses and Dissertations

Two studies evaluated the communication approach to rapid display responses (RDRs) to others by 1) examining the influence of specific communicative goals on RDRs and, 2) identifying the social outcomes associated with correspondence between communicative goals and responses. Both studies showed that people in general can change the magnitude of their most rapid responses according to communication goals to either respond or suppress responses. For some stimulus-response pairs, the ability to flexibly deploy RDRs to align with goals is associated with positive social outcomes for those who are socially active. In Study 1, individual differences among socially active first-year college …

China And The United States' Recovery From The Global Financial Crisis, Yufei Wang

Electronic Theses and Dissertations

Faced with the global financial crisis, which has a large impact on the world's economy, China and the United Stated took different actions to pull the economy out of it, based on the fairly different financial, fiscal, and even political systems they have. This thesis focuses on the comparison of the financial and fiscal systems and trade structures between the two different countries, and how these have impact on their stimulus packages, thus influencing the economic recovery as a whole.

Hybrid Sensing And Adaptive Control For Direct Brain Actuation Of Artificial Limbs, Christopher Aasted

Electronic Theses and Dissertations

Developing a non-invasive direct brain control of artificial limbs is both challenging and desirable. Such a sensory and control system, if successful, will have a profound impact on the disabled. In this dissertation, we present the design and development of a non-invasive, hybrid sensory system, which uses near-infrared spectroscopy (NIRS) and electroencephalography (EEG) to measure brain activity with simultaneous electromyography (EMG) to provide feedback data in a healthy limb. Through the combination of these sensory techniques, we have successfully trained a control system capable of mapping brain activity onto muscle actuation. The design of a control algorithm capable of automatic …

Palestinian Women: Mothers, Martyrs And Agents Of Political Change, Rebecca Ann Otis

Electronic Theses and Dissertations

This dissertation seeks to understand the role of women as political actors in the rise of Islamo-nationalist movement in Palestine. Using a historical and ethnographic approach, it examines the changing opportunity structures available to Palestinian women in the nationalist struggle between 1987 and 2007. It looks into the sites of political engagement of Palestinian women as mothers, organizers and political candidates, suicide bombers, and nonviolent activists with attention paid to the evolution of the Islamist ideology within these four pathways for political participation. The goal of this work is to engage the question of how some Palestinian women who appear …

Global Human Rights In An Age Of Consumerism, Joel Richard Pruce

Electronic Theses and Dissertations

This dissertation traces the emergence of the global human rights movement, investigates the role of popular culture as a vehicle for mobilization, and critically examines why the movement has failed to adequately politicize its supporters in the process. Beginning in the mid-1970s, a broad shift began to take place in which ordinary people were routinely confronted with human suffering, as conflict and crisis assumed a role as ritualized news events. The public response to these phenomena demonstrated a capacity for solidarity and engagement based on cosmopolitan premises. The inception of a collective ethos of compassion, an awareness of the other …

Adaptive Responses Of Branchial Morphology To Hypoxia In The Neotropical Electric Fish Genus Brachyhypopomus, Leilani B. Pathak

Electronic Theses and Dissertations

Many tropical aquatic environments worldwide are characterized by intermittent or prolonged hypoxia (low dissolved oxygen). Nevertheless, many tropical freshwater fishes are able to inhabit these challenging environments via a range of morphological, physiological and behavioral adaptations. Brachyhypopomus is a diverse genus of weakly electric fishes represented by 28 known species distributed from Panama to Argentina. 17 species are restricted to permanently normoxic habitats (blackwater rivers and terra firme streams), eight species are restricted to seasonally or perennially hypoxic habitats (whitewater floodplains of large tropical rivers or permanent swampy habitats), and three species are eurytopic (occur in both seasonally hypoxic and …

Assessing Common Variance In Psychopathy Measures, Rochelle Taormina

Electronic Theses and Dissertations

Youth who demonstrate callous and unemotional traits along with aggressive antisocial behaviors are more likely than youth who do not display callous and unemotional traits to continue those acts into adulthood. Similarly there is support in the literature that the psychopathy construct measured in adulthood are evidenced in youth. For example, psychopathy traits measured by the Psychopathy Check List-Revised (PCL-R), noted as the gold standard assessment measure of psychopathy in adults, has been slightly modified for use with youth (i.e., Psychopathy Checklist - Youth Version [PCL-Y V]). The PCL-YV has been identified as a useful predictor of aggressive behaviors among …

The Application Of Melatonin And Platelet-Rich Plasma In The Development Of A Bioactive Calcium Aluminate Bone Regenerative Scaffold, William Clafshenkel

Electronic Theses and Dissertations

Over 500,000 bone graft procedures are conducted annually within the United States. Autografts contribute to donor site complications and disease transmission with allografts has been described. Many ceramics are only osteoconductive and are brittle, limiting their clinical use. Thus, the objective of this study was to create a bone substitute with osteoinductive properties similar to natural bone using the ceramic biomaterial calcium aluminate (CA). Calcium aluminate materials are durable and remain moldable for an extended period of time at room temperature. Further, the surfaces of CA scaffolds can be modified with biological agents through simple chemical means to locally deliver …