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Elevation Of Cardiac Glycolysis Reduces Pyruvate Dehydrogenase But Increases Glucose Oxidation., Qianwen Wang
Elevation Of Cardiac Glycolysis Reduces Pyruvate Dehydrogenase But Increases Glucose Oxidation., Qianwen Wang
Electronic Theses and Dissertations
Heart failure is the most frequent cause of mortality in western countries. Currently, there is no cure treatment for heart failure and the long term survival rate following heart failure is poor, with one third of patients dying within a year of diagnosis. Thus, new therapeutic targets have to be developed. Enhanced glycolysis is a very common phenomenon in the development of heart failure and maybe a target for drug development. However it is not know whether the increased glycolysis is a cause or an effect of heart failure. Also, metabolic modulators to increase glucose use by the heart have …
Gyorgy Kurtag's Kafka Fragments, Op. 24 : Fragment As Form., Kaitlin Doyle
Gyorgy Kurtag's Kafka Fragments, Op. 24 : Fragment As Form., Kaitlin Doyle
Electronic Theses and Dissertations
This paper discusses the Kafka Fragments for Soprano and Violin, a work of forty movements composed by Hungarian composer, Gyorgy Kurtag, in 1985 through 1987. The piece is based Kurtag's own compilation of fragments written by Franz Kafka, which were taken from Kafka's diaries, personal letters, and Blue Octavio Notebooks. They are some of the most personal and intimate examples that exist within Kafka's body of writing. The paper primarily addresses Kurtag's compositional process as illustrated through the Kafka Fragments and attempts to provide insight about his especially unique qualities as a composer. The main topics of the paper include …
A Reconsideration Of The Apse Of Hagia Eirene., Eston Adams 1979-
A Reconsideration Of The Apse Of Hagia Eirene., Eston Adams 1979-
Electronic Theses and Dissertations
The mosaic of the cross in the apse of Hagia Eirene in Constantinople is examined in order to determine the imperial patron responsible for it's construction. Key points in this study are Orthodox image veneration, Iconoclast doctrine and the events of the era of Byzantine iconoclasm (726-843 C. E.). Supplementing the written evidence is a study of the architecture of Hagia Eirene and what it reveals about the date of the apse mosaic's construction. Other important monuments discussed in comparison with the mosaic in Hagia Eirene include the apse of Hagia Sophia in Thessaloniki and the now destroyed apse of …
Pattern Play : Pieced Works On Paper., Gweneth A. Dunleavy 1954-
Pattern Play : Pieced Works On Paper., Gweneth A. Dunleavy 1954-
Electronic Theses and Dissertations
This thesis explores pattern juxtaposition using traditional American quilt block designs as the compositional basis for nine works pieced from screen printed paper. In the 1970s, the quilt was celebrated for its apparent connection to Modernist design and was reclaimed by many feminist artists including Miriam Schapiro as a symbol of the exclusion of women's crafts from the arts hierarchy. The tension between these two perspectives continues today in the contemporary art quilt movement. Block designs are tightly organized, relying on grids and repeated geometric forms to communicate multiple patterns simultaneously. Controlled placement of light and dark pieces can create …
Reconciliation Of Il-1ss Loss With Trif-Biased Tlr4 Signaling By Monophosphate Lipid A., Chelsea A. Embry
Reconciliation Of Il-1ss Loss With Trif-Biased Tlr4 Signaling By Monophosphate Lipid A., Chelsea A. Embry
Electronic Theses and Dissertations
Monophosphoryl Lipid A (MPLA), a derivative of LPS endotoxin, is a TLR4 agonist that displays as little as 0.1-1% as much toxicity as its parent molecule while retaining immunostimulatory properties. We discovered that MPLA activates a TRIF-biased pattern of TLR4 signaling, resulting in reduced production of MyD88-dependent pro-inflammatory factors, and credited TRIF-bias for MPLA's reduced toxicity. A contemporary study showed that MPLA fails to promote maturation of the potent inflammatory cytokine IL-1ß. This dissertation seeks to reconcile MPLA's TRIF-biased signaling with IL-1 ß loss, and to determine the ultimate cause of MPLA's reduced toxicity compared to LPS. We find that …
Image Annotation And Retrieval Based On Multi-Modal Feature Clustering And Similarity Propagation., Mohamed Maher Ben Ismail 1979-
Image Annotation And Retrieval Based On Multi-Modal Feature Clustering And Similarity Propagation., Mohamed Maher Ben Ismail 1979-
Electronic Theses and Dissertations
The performance of content-based image retrieval systems has proved to be inherently constrained by the used low level features, and cannot give satisfactory results when the user's high level concepts cannot be expressed by low level features. In an attempt to bridge this semantic gap, recent approaches started integrating both low level-visual features and high-level textual keywords. Unfortunately, manual image annotation is a tedious process and may not be possible for large image databases. In this thesis we propose a system for image retrieval that has three mains components. The first component of our system consists of a novel possibilistic …
The Name Of The Sandwich Itself., Amanda Lee Phillips
The Name Of The Sandwich Itself., Amanda Lee Phillips
Electronic Theses and Dissertations
The poems in this collection seek to explore and highlight connections between the familiar domestic realm (often seen in depictions of food preparation and consumption, social events, or material possessions) and shifting, sometimes ambiguous relationships between people. Gender, in particular, is examined, exaggerated, and/or de constructed to underscore the author's ongoing interest in the ways in which expected male and female roles are constructed and performed within personal interactions. The poems here exhibit a variety of different tones, ranging from darkly comic to contemplative, from joyous to solemn. The author believes it possible for poems to possess both comedic and …
Sound Image And Organic Form In Höller's "Regen-Kanon" (Sphären, Iv)., Adriana Guzman 1977-
Sound Image And Organic Form In Höller's "Regen-Kanon" (Sphären, Iv)., Adriana Guzman 1977-
Electronic Theses and Dissertations
"Regen-Kanon" is the fourth of six pieces or "sound images" in the orchestral cycle Spharen, composed by York Holler between 2001 and 2006. The first four movements, namely "Wolkengesang" ("Song of the Clouds"), "Windspiel" ("Wind Chimes"), "Erdschichten" ("Layers of Earth"), and "Regen-Kanon" ("Rain Canon") are related to Holler's experiences of particular landscapes and consequently to associated impressions of nature, whereas the fifth and sixth movements, "Feuerwerk" ("Fireworks") and "Spharentrauer" ("Sorrow of the Spheres") convey different kinds of images. Holler cites the influence of the philosophers Empedocles, Henri Bergson, and Peter Sloterdijk on his musical language and on Spharen in particular. …
The Regulatory Function Of Social Referencing In Preschoolers With Down Syndrome Or Williams Syndrome., Angela E. John
The Regulatory Function Of Social Referencing In Preschoolers With Down Syndrome Or Williams Syndrome., Angela E. John
Electronic Theses and Dissertations
The present project examined the regulatory function of social referencing in two neurodevelopmental disorders that have been well defined genetically and are characterized by differing patterns of socio-cognitive development: Down syndrome (DS) and Williams syndrome (WS). In addition, since the social referencing process requires children to coordinate three fundamental abilities (initiation of joint attention, gaze following, emotional responsivity), the present project also included three follow-up studies which examined these abilities separately. Participants were 21 children with DS (M age = 4.97 years; SD = .74) and 21 children with WS (M age = 4.92 years; SD = .76) closely matched …
Survey Of Pediatric Residents Regarding Communication Disorders And Augmentative And Alternative Communication., Karen J. Coulter
Survey Of Pediatric Residents Regarding Communication Disorders And Augmentative And Alternative Communication., Karen J. Coulter
Electronic Theses and Dissertations
Children with general communication impairments as well as complex communication needs rely on pediatricians to prescribe the services of speech language pathologists. In light of this continuing and increasing need, it is important to ascertain whether medical residents are receiving the necessary training in their educational program to fulfill their role. We need to understand how pediatric residents perceive their current level of abilities particularly within the framework of the current ACGME competencies. The purpose of this dissertation was to identify possible differences across pediatric resident levels regarding competence within three constructs, Medical Education, Medical Knowledge and Professional Practice, with …
How Collaborative The Collaboration? : Assessing The Collaboration Of Services For Juvenile Offenders., James G. Dickerson
How Collaborative The Collaboration? : Assessing The Collaboration Of Services For Juvenile Offenders., James G. Dickerson
Electronic Theses and Dissertations
Juvenile delinquency with co-occurring substance abuse and mental health disorders has become an increasing problem within the United States. In part this can be attributed to the excessive number of delinquent youth entering the juvenile justice system with untreated substance abuse and/or mental health disorders-thus requiring juvenile justice to become a default system for substance abuse and mental health intervention and treatment services. In an effort to combat this problem, governmental, mental health, social support agencies, and school systems have formed interagency collaborations to provide more effective treatment services. One such interagency collaboration is the JETS Program, a court diversion …
Requirement Of Ssdelseed-Motif Of Escherichia Coli F1FO Atp Synthase In Antimicrobial Peptide Binding., Junior Kom Tayou
Requirement Of Ssdelseed-Motif Of Escherichia Coli F1FO Atp Synthase In Antimicrobial Peptide Binding., Junior Kom Tayou
Electronic Theses and Dissertations
F1FO ATP synthase is a membrane bound enzyme capable of synthesizing and hydrolyzing ATP. Lately, α-helical cationic peptides such as melittin and melittin related peptide (MRP) were shown to inhibit E. coli ATP synthase. The proposed but unconfirmed site of inhibition is βDELSEED-motif formed by the residues 380-386, located at the interface of α/β subunit of ATP synthase. This project was a mutagenic analysis of βDELSEED-motif residues to understand the binding mechanism and mode of action of peptide inhibitors. The study addressed 2 main questions: Are the antibacterial/anticancer effects of these peptides related to their inhibitory action …
A Study Of Habitat Selection And Fluctuating Asymmetry Of Amybstoma Tigrinum At Henderson Island Wildlife Management Area In Jefferson County Tn., Christopher Scott Ogle
A Study Of Habitat Selection And Fluctuating Asymmetry Of Amybstoma Tigrinum At Henderson Island Wildlife Management Area In Jefferson County Tn., Christopher Scott Ogle
Electronic Theses and Dissertations
Studies were conducted on a population of tiger salamanders, Ambystoma tigrinum, at Henderson Island Wildlife Management Area in Jefferson County, TN. Tests were conducted to locate the nonbreeding habitat of the salamanders and to detect any difference in fluctuating asymmetry (FA) between larval populations in a large, permanent pond and an ephemeral wetland. Drift fences were installed with pitfall traps at selected locations around each pond to determine nonbreeding habitat use by adults. Most adult salamanders were found using a blackberry (Rubus sp.) dominated old-field, a grassy field, and a shrub-grass mix field, which were all adjacent …
Spatial Ecology Of The Spotted Salamander Ambystoma Maculatum During The Nonbreeding Season., Dale Patrick Ledford
Spatial Ecology Of The Spotted Salamander Ambystoma Maculatum During The Nonbreeding Season., Dale Patrick Ledford
Electronic Theses and Dissertations
Spotted Salamanders, Ambystoma maculatum, are a widely distributed pond-breeding amphibian that spends an estimated 95% of its life in woodlands surrounding breeding ponds. Their terrestrial ecology remains poorly understood. Few studies have tracked the movement patterns of Spotted Salamanders, and they have given limited information on fine scale patterns. Studies of distribution around vernal pool environments have brought increased attention to their terrestrial ecology. To this end I tracked a sample of Passive Integrated Transponder (PIT) tagged animals with a Radio Frequency Identification Device (RFID). Quadrat-variance methods and a Poisson distribution were used to analyze spatial distribution patterns over …
Sulforaphane Prevents Acetaminophen-Induced Hepatic Injury In Mice., Robin H. Schmidt 1984-
Sulforaphane Prevents Acetaminophen-Induced Hepatic Injury In Mice., Robin H. Schmidt 1984-
Electronic Theses and Dissertations
Sulforaphane (SFN), an isothiocyanate found in cruciferous vegetables, is known to confer antioxidant protection in vivo. Rather than directly reacting with free radicals, however, SFN works by inducing Nrf2, a transcription factor that binds to the promoter regions of several known antioxidant genes and enhances detoxification. Because oxidative stress is a major contributor to acetaminophen (APAP)-induced hepatotoxicity, SFN may defend the liver against APAP overdose by activating the Nrf2 pathway and increasing endogenous antioxidant response. To test this hypothesis, mice were pre-treated with SFN for four days, injected with APAP on the fifth day, and sacrificed shortly thereafter. APAP overdose …
Roles Of Vamp3 In Melanoma Cell Migration And Integrin Trafficking., Yaman Babi 1981-
Roles Of Vamp3 In Melanoma Cell Migration And Integrin Trafficking., Yaman Babi 1981-
Electronic Theses and Dissertations
Integrins are major receptors for cell adhesion to the extracellular matrix, and play key roles in various cellular processes including adhesion, migration, proliferation and survival. Apart from developmental and physiological events, integrins are involved in many pathological conditions including cancer metastasis. During cell migration, the exocytosis of integrins at the cell front contributes to the formation and stabilization of protrusions. Previous studies showed that VAMP3, a SNARE protein that mediates exocytosis, is important in integrin trafficking and cell migration. However, the mechanism by which VAMP3 participates in integrin trafficking is not clear. Since VAMP3 is over expressed in melanoma, the …
Biomechanics And Injury Assessment Of Household Falls In Children : Clinical, Anthropomorphic Surrogate, And Computer Simulation Studies., Angela Knight Thompson
Biomechanics And Injury Assessment Of Household Falls In Children : Clinical, Anthropomorphic Surrogate, And Computer Simulation Studies., Angela Knight Thompson
Electronic Theses and Dissertations
Pediatric short-distance falls, especially from beds or other furniture, are common false histories given by caretakers to cover up abusive trauma. However, short-distance falls are also a common occurrence in young children. Knowledge of the types and severity of injuries that can result from these short falls can aid clinicians in distinguishing between inflicted and non-inflicted injuries. Early detection of abuse may lead to prevention of further escalating injuries and, in some cases, prevent the death of the child. The purpose of this study was to describe relationships between biomechanical measures and injury potential in short-distance household falls. This study …
Variation In The Modified First Metatarsal Of A Large Sample Of Tapirus Polkensis And The Functional Implications For Ceratomorphs., Patrick Lawrence Hawkins
Variation In The Modified First Metatarsal Of A Large Sample Of Tapirus Polkensis And The Functional Implications For Ceratomorphs., Patrick Lawrence Hawkins
Electronic Theses and Dissertations
The Mio-Pliocene age Gray Fossil Site of northeastern Tennessee has the largest collection of tapir postcranial skeletons in the world. Though representing a single species, a few localized structures show high variability. This paper deals with variation of the first metatarsal, which in tapirs was reduced as an early adaptation for running and then retrofitted to serve as a special origin for flexors and adductors of the proximal phalanges. The first metatarsal connects the medial ankle with a posterior process of the third metatarsal in tapiroids. In Tapirus indicus, T. webbi, and 6 out of 31 T. polkensis …
Clustering Digital Ink Content To Assist With The Grading Of Student Work., Jared Hatfield
Clustering Digital Ink Content To Assist With The Grading Of Student Work., Jared Hatfield
Electronic Theses and Dissertations
In recent years the use of Tablet PCs in education has received a great deal of attention. Improved note-taking and lecture presentation have been the main focus of Tablet PCs in education. Currently, grading of student work collected as digital ink using Tablet PCs is still done mostly as it would be done if collected as pencil on paper. However, having content stored as digital ink provides an opportunity to perform analysis that is neither practical nor possible with pen and paper student content. Once student work is collected using DyKnow Vision, an interactive Tablet PC based classroom software tool, …
Cfd Modeling Of Center Cones, Vortex Breakers And Pressure Relief Slits In A Wind Speed Accelerator., Michael D. Lucas 1988-
Cfd Modeling Of Center Cones, Vortex Breakers And Pressure Relief Slits In A Wind Speed Accelerator., Michael D. Lucas 1988-
Electronic Theses and Dissertations
Wind power has the potential to provide access to electricity to areas lacking the resources to create industrial power plants, as well as supplement residential energy supplies. The low resource investment and ease of installation make it ideal for these scenarios; however, it is limited by the availability of a stable power source. Only 13% of the world’s land area experiences wind speeds high enough to be usable by current technology. To improve this percentage, the use of wind concentrators has been suggested. A turbine within a concentrator would experience a higher wind speed than the surrounding body of air, …
Cfd Modeling Of Entrance And Exit Geometries Of A Wind Speed Accelerator., David Russ
Cfd Modeling Of Entrance And Exit Geometries Of A Wind Speed Accelerator., David Russ
Electronic Theses and Dissertations
Current wind power technology is not economically feasible throughout most of the United States due to low average wind speeds. A design for a small-scale wind concentrator device suitable for use in areas of low wind velocity was tested using computational fluid dynamics (CFD). Using a novel approach, the device seeks to accelerate incoming air above minimum velocities required for economical power generation. The novel approach employs a funnel shaped inlet with relief vents along the circumference, so as to alleviate backpressure. Both inlet and outlet sections utilize funnel shapes with both parabolic and hyperbolic regions. All geometry and mesh …
Mapping England's Trade Through Depictions In English Emblems., Valerie J. Erickson
Mapping England's Trade Through Depictions In English Emblems., Valerie J. Erickson
Electronic Theses and Dissertations
This thesis explores the growing interaction between England and foreign countries comparing their trade with contemporary later sixteenth century and seventeenth century English emblems. The emblems used are those available over the internet from several different library and university sources. As England expanded its trade throughout the world, English emblems began to show the exchange occurring between England and its various trading partners. Historians have largely overlooked this valuable source of information. By studying emblems historians gain invaluable insight into the economy, society, politics, religion, and other matters with which England was concerned.
Partial Vs. Full Support Of The Heart With A Continuous-Flow Left Ventricular Assist Device : Implications For Myocardial Recovery., Carlo Renato G. Bartoli
Partial Vs. Full Support Of The Heart With A Continuous-Flow Left Ventricular Assist Device : Implications For Myocardial Recovery., Carlo Renato G. Bartoli
Electronic Theses and Dissertations
INTRODUCTION: Heart failure is a major and growing public health concern. Although heart failure has been considered an inexorable and progressive disorder, emerging evidence suggests that some patients may have reversible left ventricular dysfunction. Indeed, recent reports have documented the potential for myocardial recovery in humans in response to prolonged mechanical circulatory support with a left ventricular assist device (LVAD). However, myocardial recovery remains uncommon, and a strategy of unloading the failing left ventricle with a continuous-flow (non-pulsatile) LVAD has not been specifically developed to promote favorable myocardial remodeling. As a preliminary investigation, we developed a bovine model of chronic, …
The Madness Is Catching : Transsexuality And The Cartesian Subject., Andrew Edward Clark 1986-
The Madness Is Catching : Transsexuality And The Cartesian Subject., Andrew Edward Clark 1986-
Electronic Theses and Dissertations
This project uses the work of Michel Foucault and Lynne Huffer to examine the creation of the transsexual subject in 1950s American sexology through the Cartesian subject. I argue that medical professionals utilized the Cartesian subject as a standard to create and classify transsexuality as deviant. Further, through their joining, medicine and psychology positioned the transsexual subject in both madness and abnormality. Such a position leaves transsexuals in a subject position that cannot speak for itself and requires medical qualification. I demonstrate how such a subject position, created through medicalized discursive practices, carries over into judicial discourse. I find that …
On The Cranial Osteology Of Eremiascincus And Its Use For Identification., William B. Gelnaw
On The Cranial Osteology Of Eremiascincus And Its Use For Identification., William B. Gelnaw
Electronic Theses and Dissertations
A persistent problem for Australian paleontology has been a lack of diagnostic characters for identifying lizard fossils. Eremiascincus is one of the most widespread genera in Australia, so it was examined for distinguishing features and how it fits into a model of skink evolution. Skulls of Eremiascincus were examined within five separate contexts: 1) a description of the cranial osteology, 2) a qualitative comparison of individual cranial elements of Eremiascincus to closely related Ctenotus, 3) a description of the cranial allometry in Eremiascincus using linear morphometrics, 4) using cranial morphometrics of skinks to deduce their phylogeny, and 5) using …
Molecular Modulation Of A-Subunit Visit-Dg Sequence Residue Asp-350 In The Catalytic Sites Of Escherichia Coli Atp Synthase., Sneha R. Jonnalagadda
Molecular Modulation Of A-Subunit Visit-Dg Sequence Residue Asp-350 In The Catalytic Sites Of Escherichia Coli Atp Synthase., Sneha R. Jonnalagadda
Electronic Theses and Dissertations
ATP Synthase is the fundamental means of cellular energy production in animals, plants, and almost all microorganisms. In order to understand the mechanism of ATP catalysis, critical amino acid residues involved in Pi binding have to be identified. The αVISIT-DG sequence at the interface of α/β subunits that contains residues from 345-351 is highly conserved and αAsp-350 has been chosen because of its negative charge side chain and its close proximity (~2.8 Å) to the known phosphate binding residue αArg-376. The mutant's αD350R, αD350Q, αD350A, αR376A/D, and αG351R/A/D were generated by site directed mutagenesis and several biochemical assays were performed …
The Occurrence Of An Abdominal Fauna In An Articulated Tapir (Tapirus Polkensis) Recovered From The Miocene Gray Fossil Site Northeast Tennessee., Shannon M. Mcconnell
The Occurrence Of An Abdominal Fauna In An Articulated Tapir (Tapirus Polkensis) Recovered From The Miocene Gray Fossil Site Northeast Tennessee., Shannon M. Mcconnell
Electronic Theses and Dissertations
The analysis of samples recovered from the abdominal area of an articulated tapir from the Late Miocene (4.5-7 million bp) Gray Fossil Site, revealed a rich palyno-fauna comprised of about 94% egg/oocyst-like structures and 6% pollen and other palynomorphs. In addition, a tight grouping of six hickory nuts (Carya) was recovered from the same area suggesting that the samples represent the abdominal contents. The analysis of a sample from immediately outside the tapir produced a sample with 98% pollen and less than 0.5% egg-like structures. The size, shape, and general morphology of egg-like structures were analyzed with light …
Ecologically Friendly Food Buying And Recycling: Environmental Attitudes And Behaviors In A Tennessee Survey., Jessica Jane King
Ecologically Friendly Food Buying And Recycling: Environmental Attitudes And Behaviors In A Tennessee Survey., Jessica Jane King
Electronic Theses and Dissertations
This thesis focuses on pro-environmental attitudes and behaviors and the interactions between recycling behavior, food buying attitudes, food buying behaviors, and ecological beliefs. Following an introductory chapter, I present an article-length paper on recycling behavior to be submitted to Environment and Behavior. Data for this study came from a telephone survey of Tennessee residents (N=270). Using OLS regression analysis, I find that recycling behavior is significantly related to access to recycling facilities. I do not find a significant interaction effect between access to recycling facilities and willingness to recycle. I conclude by suggesting that pro-environmental policies need to make structural …
Population Structure Based On Age-Class Distribution Of Tapirus Polkensis From The Gray Fossil Site Tennessee., Matthew L. Gibson
Population Structure Based On Age-Class Distribution Of Tapirus Polkensis From The Gray Fossil Site Tennessee., Matthew L. Gibson
Electronic Theses and Dissertations
Individuals of Tapirus polkensis from the Gray Fossil Site exhibit an excellent level of preservation. Intact skulls collected from the site were arranged in a rough age class system separated into 7 categories based on the teeth present and amount of dental wear. Such an eruption series is useful for general comparisons amongst the individual tapirs; however, the classes do not represent an age in years due to a lack of data on living tapirs. Consequently, it is possible that some age classes may contain several years of a tapirs life, or comparatively only a few months. In this study …
Death And Its Beyond In Early Judaism And Medieval Jewish Philosophy, Adem Irmak
Death And Its Beyond In Early Judaism And Medieval Jewish Philosophy, Adem Irmak
Electronic Theses and Dissertations
Afterlife and the concept of soul in Judaism is one of the main subjects that are discussed in the academia. There are some misassumptions related to hereafter and the fate of the soul after departing the body in Judaism. Since the Hebrew Bible does not talk about the death and afterlife clearly, some average people and some scholars claim that there is nothing relevant to the hereafter. However, in this study I put the Hebrew Bible to conversation with ancient cult of the dead and Medieval Jewish philosophers Saadya Gaon and Yehuda Halevi to proof the existence of afterlife and …