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Physicochemical And Functional Properties Of Different Varieties Of Spring And Winter Peas Of South Dakota, Prakriti Dhakal
Physicochemical And Functional Properties Of Different Varieties Of Spring And Winter Peas Of South Dakota, Prakriti Dhakal
Electronic Theses and Dissertations
Peas are a good source of nutrients for both humans and animals, and they are the world's second most significant and sustainable legume. There have been studies on different kinds of pea grown in other parts of the world, but there is no information on the compositional and functional characteristics of pea varieties grown specifically in South Dakota. The objective of the study was to evaluate the proximate composition and functional properties of various pea varieties and determine if the pea variety impacted cookie properties. The proximate composition (moisture, protein, starch, and amylose), functional capacities (water holding, oil holding capacity, …
Species Distribution Modeling Of Aquilegia Brevistyla (Ranunculaceae): A Critically Imperiled Black Hills Disjunct Species, Eric Daniel Puetz
Species Distribution Modeling Of Aquilegia Brevistyla (Ranunculaceae): A Critically Imperiled Black Hills Disjunct Species, Eric Daniel Puetz
Electronic Theses and Dissertations
Unchecked human activity is contributing to rising levels of greenhouse gas emissions, changes in land use, altered disturbance/fire regimes, spread of invasive species, and loss of biological diversity and related breakdown of ecosystem services. Additionally, climatic shifts may lead to phenological mismatches between species and their environments if these changes outpace a species’ ability to adapt or migrate to a more suitable habitat. Isolated mountain populations are particularly threatened by unpredictable climatic conditions, as they may have limited migration corridors and often lower levels of genetic diversity to move or adapt, respectively. As these negative feedbacks compound on the landscape, …
Mechanical Testing Of Novel Biopolymers For The Replacement Of Petroleum-Based Plastic Hay Bale Net Wrapping, Logan Wolf
Mechanical Testing Of Novel Biopolymers For The Replacement Of Petroleum-Based Plastic Hay Bale Net Wrapping, Logan Wolf
Electronic Theses and Dissertations
The purpose of this thesis is to test biopolymers synthesized from oilseeds or produced from agricultural wastes for large bale net wrapping as a viable alternative to conventional petroleum-based plastics (PBP). The goal is to test and assess novel polymers to guide the synthesis of a benign biodegradable polymer. Biobased net wrapping will significantly reduce ingestion of PBPs in animals such as ruminants to improve digestive health and minimize cattle loss due to plastic disease. Biobased plastics will also achieve partial or complete breakdown shortly after service without depositing microplastics in the environment. This will reduce the risk of damage …
Climate Change Adaptation For Embankment Through Biogeotechnics, Debayan Ghosh
Climate Change Adaptation For Embankment Through Biogeotechnics, Debayan Ghosh
Electronic Theses and Dissertations
Problematic soil like expansive soil, and frost-susceptible soil causes significant damage to civil infrastructure. The use of calcium-based stabilizers in the treatment of sulfate-rich expansive soils is not suggested due to the formation of ettringite. Infrastructure such as pavements and embankments built on expansive soil are often exposed to the damaging impacts of freeze-thaw cycles in areas prone to seasonal freezing making them vulnerable to cracking and spalling. In this study, a native expansive soil from South Dakota with a sulfate content of more than 10,000 ppm was stabilized using biopolymer and cement. The experimental study investigated the strength and …
Plant Pathways Associated With Competition For Soybean Root Colonization By Bradyrhizobium Strains, Athira Sethu Madhavan
Plant Pathways Associated With Competition For Soybean Root Colonization By Bradyrhizobium Strains, Athira Sethu Madhavan
Electronic Theses and Dissertations
Nitrogen is a crucial nutrient for the growth and development of plants. Legume crops like soybeans develop symbiotic associations with soil bacteria from the genus, Bradyrhizobium to obtain fixed nitrogen. In this mutualistic association, rhizobia are released into root nodules that provide a compatible environment for rhizobia to grow and fix nitrogen (Symbiotic Nitrogen Fixation (SNF)). A caveat in such beneficial associations is the competition between different rhizobium strains in soil for infection and nodule occupancy. The elite inoculant strains encounter competition by indigenous rhizobial population in the soil to infect and nodulate a susceptible legume host, because of which …
Movement Ecology Of Paddlefish And Walleye Reveal The Importance Of Continued Interjurisdictional Management In Riverine And Lacustrine Systems, Kaitlyn Bearden
Movement Ecology Of Paddlefish And Walleye Reveal The Importance Of Continued Interjurisdictional Management In Riverine And Lacustrine Systems, Kaitlyn Bearden
Electronic Theses and Dissertations
Fisheries systems function at broad spatial and temporal scales. Fishes within these systems are often highly mobile and move to locate adequate habitat, to feed and reproduce. As individuals navigate their environment, they potentially cross regulatory boundaries (state or federal) and or encounter physical barriers such as dams. Regulatory boundaries may not physically impede fish movement, but they are visible to fisheries managers thus the fishes within them may be vulnerable to varying management and harvest regulations. Physical boundaries (e.g., dams) are also particularly problematic for highly mobile species in large river systems. In chapter two, I documented that apparent …
Feeding Isoacids To Swine: Inclusion Level And Interactions With Dietary Fiber And Protein, Angie Patricia Benavides Infante
Feeding Isoacids To Swine: Inclusion Level And Interactions With Dietary Fiber And Protein, Angie Patricia Benavides Infante
Electronic Theses and Dissertations
In animal production, research is continually being carried out into implementing new feeding strategies, such as incorporating new alternative ingredients or additives that improve the quality of the diet, reduce the cost of diets, or have effects on intestinal health. The inclusion of branched-chain volatile fatty acids has been investigated in ruminants, and it has been found that a diet supplemented with BCVFA increases fiber digestibility as well as increases cellulolytic bacteria in the rumen. There is little information about the possible effects on pigs supplemented with BCVFA. According to this, the first study aims to evaluate the optimal inclusion …
Effects Of Low-Cost, Low-Tech Tools For Riparian Restoration On Prairie Streams In Western South Dakota, James Andrew Joseph Bolyard
Effects Of Low-Cost, Low-Tech Tools For Riparian Restoration On Prairie Streams In Western South Dakota, James Andrew Joseph Bolyard
Electronic Theses and Dissertations
Despite making up less than two percent of the overall landscape in the arid and semi-arid western US, riparian areas are a crucial resource for agriculture, livestock, and wildlife. However, many have impaired function and reduced riparian cover. Low-Cost, Low-Tech Tools (LCLTT) are a subset of Process-Based Restoration (PBR) used for riparian restoration that were chosen for their cost-effectiveness and minimal technical requirements. LCLTT has been tested in mountainous areas of the western US but only recently implemented in the Northern Great Plains (NGP). Given their novelty as an approach toward restoration for the region, professional restoration and landowner communities …
Development Of Innovative Flocculation Technologies For Agricultural Water Treatment, Noor Haleem
Development Of Innovative Flocculation Technologies For Agricultural Water Treatment, Noor Haleem
Electronic Theses and Dissertations
The development of innovative flocculation technologies is essential for addressing the challenges of agricultural water treatment. These technologies play a crucial role in removing contaminants such as suspended solids and nutrients, thereby ensuring safer water for irrigation and livestock consumption. By enhancing water quality and wastewater management, they contribute significantly to environmental sustainability and public health in agricultural communities. This comprehensive thesis extensively explores various dimensions of flocculation, with a focused effort on methodologies and resources aimed at strengthening sustainability and efficiency. A pivotal aspect of the research involves synthesizing cationic starch (CS), a flocculant derived from an underutilized resource, …
Advancing Biological Applications Through Microfluidic-Based Tool Development, K.M. Taufiqur Rahman
Advancing Biological Applications Through Microfluidic-Based Tool Development, K.M. Taufiqur Rahman
Electronic Theses and Dissertations
This research undertook an interdisciplinary approach, integrating bioengineering, microbiology, molecular biology, and systems biology to investigate bacterial dynamics behavior. Specifically, it delved into the development of microfluidic devices for biological applications such as bacterial cell counts, real-time observation of plant roots (here, specialized lectin-coated microbeads are used that mimic root characteristics), and soil microbe interactions. Furthermore, Next-Generation Sequencing and systems biology methodologies were employed to explore the intricate, multifaceted survival mechanisms of Escherichia coli persister population. Studying and quantifying persisters or testing for the existence of VBNC (viable but nonculturable) is challenging. These experiments require precise counts. It has been …
The Relationship Of Macronutrient Intake With Growth In Children With Type 1 Diabetes Mellitus, Jessica L. Freeling
The Relationship Of Macronutrient Intake With Growth In Children With Type 1 Diabetes Mellitus, Jessica L. Freeling
Electronic Theses and Dissertations
Child growth, a sensitive metric of overall health, results from the intricate interplay of nature and nurture. While the importance of nutrition in child growth is well established, growth trajectories exhibit substantial individual variability, influenced by sex and age, and often characterized by nonlinear patterns. Inadequate nutrition or disease can hinder growth, with potential for recovery upon proper nutrition or acute disease resolution. However, chronic disease or persistent malnutrition may lead to permanent growth perturbation. Notably, before the advent of insulin, chronic stunting and wasting were hallmarks of Type 1 diabetes mellitus (T1DM), though the specific impacts under modern standard …
The Influence Of By-O-Reg+ Beef, An Oregano-Based Essential Oil Supplement, On Growth Performance, Carcass Traits And Meat Quality Of Finishing Beef Steers, Bergin Mackenzie Debruin
The Influence Of By-O-Reg+ Beef, An Oregano-Based Essential Oil Supplement, On Growth Performance, Carcass Traits And Meat Quality Of Finishing Beef Steers, Bergin Mackenzie Debruin
Electronic Theses and Dissertations
The objective of this thesis was to determine the influence of an oregano-based essential oil (OEO; By-O-Reg+ Beef), on growth performance, carcass traits, and meat quality of beef steers finished in an all-natural program. Yearling steers were allotted to 16 pens (n = 8 pens per treatment, 8 steers per pen). Treatments included: 1) control (CON) fed no oregano-based essential oil and 2) group fed 4 g/steer daily of By-O-Reg+ Beef. Steers were harvested on day 149 of the feeding period. Standard carcass data was collected and instrumental color (L*, a*, b*) was recorded. Strip loins were collected from a …
Using The Disc Personality Assessment To Enhance Organizational Climate And Culture At A Mississippi University, Brian Carlyle Grizzell
Using The Disc Personality Assessment To Enhance Organizational Climate And Culture At A Mississippi University, Brian Carlyle Grizzell
Electronic Theses and Dissertations
Employee turnover presents a costly challenge for institutions of higher learning. This includes significant financial burdens, diminished productivity, and disruptions in business operations. Moreover, high employee turnover erodes morale and negatively influences organizational climate and culture. According to the literature, many organizations have incorporated tools such as the DiSC, a personality assessment tool that measures individuals’ behavioral styles based on four key traits: Dominance (D), Influence (I), Steadiness (S), and Conscientiousness (C), to enhance team cohesion and improve person-environment fit (PE-Fit). However, limited research exists on whether the DiSC assessment is effective in addressing these issues in a higher education …
Spatial Variation Of Microbial Communities In Aquatic Ecosystems In The Southeastern United States, Jordan Heiman
Spatial Variation Of Microbial Communities In Aquatic Ecosystems In The Southeastern United States, Jordan Heiman
Electronic Theses and Dissertations
Spatial variation in bacterial communities, or bacterial biogeography, is important for understanding the role of microorganisms in biogeochemical cycles. In the Southeastern United States, aquatic ecosystems are highly biodiverse and imperiled, yet few studies have investigated bacterial biodiversity and biogeography in this region. In this dissertation, I aimed to understand the bacterial biogeography in aquatic ecosystems in the Southeastern United States and how this spatial variation relates to abiotic factors in these ecosystems. To do this, I analyzed biogeographic patterns in bacterial communities from three distinct types of aquatic ecosystems (rivers, a lake, and beaches) and conducted a microcosm experiment …
Isolation Of Novel Myxobacteria And Progress Towards Heterologous Expression Of Uncharacterized Secondary Metabolites, Andrew Ahearne
Isolation Of Novel Myxobacteria And Progress Towards Heterologous Expression Of Uncharacterized Secondary Metabolites, Andrew Ahearne
Electronic Theses and Dissertations
Myxobacteria, first observed by Roland Thaxter in the late 19th century, are known for their unique swarming behavior, complex fruiting body formation and biosynthetic potential. Myxobacteria are noted for their large genomes and the presence of numerous biosynthetic gene clusters (BGCs) that hint at their potential to produce novel metabolites with therapeutic properties. Isolation of myxobacteria utilizing E. coli and filter paper baiting yielded 20 myxobacteria isolated from rhizospheric soil samples in North America. Among these isolates, nine were identified as novel species, representing the genera Archangium, Myxococcus, Nannocystis, Polyangium, Pyxidicoccus, Sorangium, and Stigmatella. Comprehensive growth profiles, biochemical assays, and …
Formulation Design And Development For Extended-Release Drug Delivery System, Sheng Feng
Formulation Design And Development For Extended-Release Drug Delivery System, Sheng Feng
Electronic Theses and Dissertations
The drug delivery system enables the release of the active pharmaceutical ingredient to achieve a desired therapeutic response. Conventional, non-controlled drug delivery systems are unable to deliver the drug at a sustained rate which leads to poor bioavailability, fluctuations in plasma drug concentration, and potential side effects. The extended drug delivery system enables drug delivery at a sustained or predetermined rate to achieve maximum efficacy and safety. Different routes of drug administration, along with various extended-release dosage forms have been extensively developed such as oral delivery, parenteral delivery, transdermal delivery, ocular delivery, and tumor delivery among others. This dissertation developed …
Development Of Quercetin And Moxifloxacin Combination In-Situ Nanoemulgels For Wound Healing., Shravani Padhye
Development Of Quercetin And Moxifloxacin Combination In-Situ Nanoemulgels For Wound Healing., Shravani Padhye
Electronic Theses and Dissertations
The study aimed to develop an in-situ gel that could potentially be sprayed on the skin for faster and enhanced wound healing. Quercetin (QCT) is a bioflavonoid, which has potent anti-inflammatory properties and has shown enhanced wound closure along with good antimicrobial activity, particularly against Staphylococcus aureus (S. aureus) and Pseudomonas aeruginosa (P. aeruginosa) which typically infect a wound. Moxifloxacin Hydrochloride (MOX) is a broad-spectrum antibiotic that has topically shown activity against Methicillin Resistant S. aureus (MRSA) and, in combination with Quercetin, could provide better and quicker wound healing as compared to the current treatment available. QCT and MOX nanoemulsions …
Ecological And Evolutionary Ramifications Of Host-Parasite Interaction In Aquatic And Model Ecosystems, Akacia Halliday-Isaac
Ecological And Evolutionary Ramifications Of Host-Parasite Interaction In Aquatic And Model Ecosystems, Akacia Halliday-Isaac
Electronic Theses and Dissertations
Host-parasite interactions are ubiquitous and have negative risks and consequences on individual, population, and evolutionary scales. These risks and consequences include altered population densities, changes in interspecies interactions, and rapid changes in host phenotypes. In this thesis, I seek to understand the ecological and evolutionary ramifications of host-parasite interactions within ecosystems. To do this, I investigated the presence and environmental correlates of potential host-parasite interactions in a freshwater ecosystem and used a model ecosystem to explore how past host-parasite coevolution affects community assembly dynamics and future adaptation in the presence of new stressors. To examine the presence of potentially parasitic …
Acoustic Localization In Reverberant Environment, Xing Yang
Acoustic Localization In Reverberant Environment, Xing Yang
Electronic Theses and Dissertations
The main goal of this dissertation is to develop algorithms to accurately locate and detect underwater oil leakages through sounds emitted by oil-induced bubbles recorded by passive hydrophones. These algorithms aim to create an early warning system to prevent or identify catastrophic oil spills from pipelines, wellheads, and seafloor seepage.
"'This May Not Be War, But Rather Statesmanship': Sherman's March Through Griswoldville, Milledgeville, And Greater Savannah", Matthew Ryan Lempke
"'This May Not Be War, But Rather Statesmanship': Sherman's March Through Griswoldville, Milledgeville, And Greater Savannah", Matthew Ryan Lempke
Electronic Theses and Dissertations
This dissertation argues that four communities in Confederate Georgia visited by Union soldiers during Sherman’s March to the Sea reorients our understanding about the state’s continued ability to resist the United States military, the level and variations of destruction, the rationales and motivations behind targeted actions, the multiplicity of experiences among diverse participants, willing and unwilling alike, and of the campaign’s broader effectiveness. The first two communities, Griswoldville and Milledgeville, were indispensable locations that set in motion a coalescence of military and political setbacks from which Confederate Georgia did not recover. As the march progressed and entered coastal communities, the …
Effects Of Off-Season Fall-Winter Farm Field Flooding On Nitrogen Gas Production, Andrew Rosson
Effects Of Off-Season Fall-Winter Farm Field Flooding On Nitrogen Gas Production, Andrew Rosson
Electronic Theses and Dissertations
Increased nitrogen (N) fertilizer use and cultivation of N-fixing crops have dramatically increased agricultural N inputs to the global N cycle. Excess N on agricultural lands is highly susceptible to loss through runoff or atmospheric emissions, potentially as a greenhouse gas (GHG). Nitrous oxide (N2O), a GHG with a warming potential ~300 times that of carbon dioxide (CO2), primarily enters the atmosphere through denitrification, which converts bioavailable nitrate (NO3-) to inert nitrogen gas (N2), with N2O as an intermediate. Wetlands are crucial for de-nitrification and N regulation due to their wet, anoxic soils, but have declined worldwide, including substantial losses …
Ftir Microspectroscopy For The Investigation Of Microplastic Pollution, Automotive Paint Layers, And Prehistoric Rock Paint With An Emphasis On Analytical Method Development, Kendall Wontor
Electronic Theses and Dissertations
The research detailed in this dissertation centers on the development of new analytical methods using chemical imaging microspectroscopy, primarily μ[micro]-FTIR, for applications in environmental, forensic, and archeological chemistry. The state-of-the-art instrument (LUMOS II) used in this research combines optical microscopy with IR spectroscopy, allowing sample visualization during FTIR imaging and micro-analysis.
Chapter 1 serves as an introduction and provides background detail on the instrumentation and technique. Chapter 2 describes the use of fluorescent microscopy to quantify microplastics (MPs) in oysters from the Mississippi Sound. High concentrations of putative MPs were found, with sites inside bays near population centers displaying higher …
Formulation Development Of Cannabidiol Using Various Technologies As An Approach To Enhance Its Solubility And Oral Bioavailability, Iman Taha
Electronic Theses and Dissertations
Cannabidiol (CBD) is a crystalline compound extracted from a high-CBD variety of the Cannabis sativa plant. It has various pharmacological effects, including antipsychotic, anti-inflammatory, anti-seizure, and anxiolytic properties. However, developing CBD formulations presents several challenges due to its high lipophilicity (log P of 6.3), poor water solubility (0.1 μg/mL), and significant first-pass metabolism, which results in low oral bioavailability, estimated at just 6%. Furthermore, research has demonstrated that CBD is susceptible to degradation from exposure to light, temperature, and oxidation during formulation. Currently, Epidiolex is the only commercially available preparation containing CBD that has been approved by the US-FDA for …
Formulation And Characterization Of Quetiapine Fumarate Floating Bioadhesive Tablets, Ajay Reddy Kolipaka
Formulation And Characterization Of Quetiapine Fumarate Floating Bioadhesive Tablets, Ajay Reddy Kolipaka
Electronic Theses and Dissertations
Quetiapine fumarate (QF) is an antipsychotic drug, and it has a plasma half-life of 6 hours. The chemical structure of QF has nitrogen groups making it highly soluble in acidic pH and slightly soluble in alkaline pH. This study aimed to develop the QF gastroretentive tablets by TSMG technology comprising floating and mucoadhesive approach by using different viscosity grades of HPMC to improve absorption by prolonging its gastric residence time. The floating tablets were prepared using the Twin screw melt granulation (TSMG) technology, and the impact of polymer concentration and viscosity grades of HPMC on the floating ability and drug …
Examining The Relationship Between Toddlers’ Sleep Patterns, Negative Parenting, And Executive Function, Morgan Elizabeth Harris
Examining The Relationship Between Toddlers’ Sleep Patterns, Negative Parenting, And Executive Function, Morgan Elizabeth Harris
Electronic Theses and Dissertations
Negative parenting can often be described as having three domains (i.e., laxness, verbosity, and over-reactivity, Arnold et al., 1993; Rhoades & O’Leary, 2007), which may have relations to toddlers’ behaviors, like executive function (EF) and sleep. However, this field is understudied, especially in early childhood development. One possible explanation for the lack of research in this field is that it can be difficult to study executive function in toddlers due to variability in the stability of regulatory behaviors and emerging regulatory abilities at this age range. Although positive sleep patterns (e.g., quality and quantity) have been linked to executive function, …
Il-17a Inhibitors For The Treatment Of Psoriasis, Mangesh Bankhele
Il-17a Inhibitors For The Treatment Of Psoriasis, Mangesh Bankhele
Electronic Theses and Dissertations
Psoriasis is a long-lasting skin condition caused by the immune system, which is characterized by red, scaly areas. It mainly affects the scalp, elbows, knees, and lower back. Psoriasis, which affects around 2-3% of the world's population, has a substantial influence on the quality of life of people who suffer from it. The disorder arises due to an atypical immunological response in which the immune system mistakenly attacks skin cells, causing fast cell reproduction, inflammation, and excessive growth. Psoriasis can be treated with topical therapies, systemic drugs, and biologics. Topical therapies, including corticosteroids, vitamin D analogs, and retinoids, are commonly …
Indirect And Direct Pathways Of Migratory Shorebird Effects On Nitrogen Cycling Within Temporarily Flooded Agricultural Fields, Victoria Blocker
Indirect And Direct Pathways Of Migratory Shorebird Effects On Nitrogen Cycling Within Temporarily Flooded Agricultural Fields, Victoria Blocker
Electronic Theses and Dissertations
The global human population continues to grow exponentially, and agriculture will need to become more productive to meet growing food demands. Humans also need clean water and other services that ecosystems provide. This requires future agriculture production to reduce environmental and wildlife impacts through improved efficiencies and best management practices. Migratory shorebirds rely on wetlands throughout North and South America as stopover habitat for rest and refueling during migration. Temporarily flooded farmlands in the Mississippi Delta have proven to be beneficial locations for shorebirds during migrations along the central flyway. This conservation practice also enhances wetland properties that promote excess …
Understanding Angler Responses To Fish Stocking Programs Across South Dakota, Riley L. Mounsdon
Understanding Angler Responses To Fish Stocking Programs Across South Dakota, Riley L. Mounsdon
Electronic Theses and Dissertations
Fisheries management is a complex process that often requires consideration of many factors to be implemented effectively. Stocking is one of the most often used fisheries management techniques for addressing a myriad of issues in the fisheries field. Stocking is also one of the largest expenses for many fisheries management agencies. Due to license sale declines, management actions including stocking, are being evaluated by many agencies to determine if there are ways to improve efficiency and effectiveness to reduce costs and enhance angler participation. For my second chapter, I evaluated the current fish stocking decision-making process within South Dakota Game, …
Influence Of Reduced Salt In Fully Cooked Ham And Sausage Cured With Natural Celery Powder On The Growth Of Listeria Monocytogenes At 4⁰C, Anne Sherod
Electronic Theses and Dissertations
This research evaluated the influence of reducing salt on outgrowth of L. monocytogenes on ready to eat (RTE) deli-style sliced ham cured with natural celery powder, fully cooked sausage links cured with traditional sodium nitrite and sausage links cured with natural celery powder, vacuum packaged and stored at 4⁰C on the outgrowth of L. monocytogenes. Experiment 1 evaluated L. monocytogenes outgrowth on ham over 153 days on the following treatments, current retail ham (HC) 2.0% salt; reduced salt 1 (HRS1) 1.5% salt; reduced salt 2 (HSR2) 1.35% salt; and reduced salt 2 without antimicrobials (HRS2WA) 1.35% salt without potassium lactate …
Scaffold Hopping For The Lead Optimization Of The Orally Active Antileishmanial Pyrrolo-Quinazoline Alkaloid Natural Product Peganine, Sunitha Jada
Electronic Theses and Dissertations
Leishmaniasis is a protozoan parasitic disease caused by the species Leishmania that affects millions of people around the world. It is a serious public health concern in the developing world with about 1 million cases and 70,000 fatalities occurring each year. It has several forms with visceral, and cutaneous leishmaniasis being the most common forms of the disease. Visceral leishmaniasis, caused by the Leishmania donovani occurs mainly in Brazil, Eastern Africa, and India, and is fatal if left untreated. The current treatments for leishmaniasis such as pentavalent antimonials, amphotericin B, miltefosine, paromomycin, pentamidine, and some azoles suffer from serious drawbacks. …