Digital Commons Network^™

Inhibition Of Pro-Inflammatory Lipid Mediators By Yersinia Pestis., Amanda Brady

Electronic Theses and Dissertations

Yersinia pestis causes the human disease known as plague. A key manifestation of plague is a delayed inflammatory response. Because this delay in inflammation is required for virulence, I was interested in defining the molecular mechanisms used by Y. pestis to evade immune recognition. Eicosanoids are produced early during infection and necessary to initiate a rapid inflammatory response. Despite the importance of these lipids in mediating inflammation, the role of eicosanoids during plague has not been previously investigated. Using an intranasal mouse model infection, I determined the kinetics of eicosanoid synthesis during pneumonic plague. I further demonstrated that LTB_{4 …}

Preliminary Evidence For The Validity And Reliability Of A Modified Adverse Childhood Experiences (Aces) Scale: The Variability In Aces Scale, Mary Jo Hedrick

Electronic Theses and Dissertations

Adverse Childhood Experiences (ACEs) research has proliferated in the last twenty years with significant research demonstrating the detrimental effects of early childhood adversity. While many measures purport to measure ACEs, very few capture the intensity of ACEs while still calculating the traditional “ACEs tally.” Thus, it is the goal of this dissertation to collect evidence for an expanded ACES measure. The Variability in Adverse Childhood Experiences Scale (VACE) measure builds upon the original ACEs and captures interval level data. Two survey-based studies were conducted in which convergent and criterion related validity and test-retest reliability evidence were collected. In …

Validation Of A Novel Heritable Rodent Model Of Drug Abuse Vulnerability In Psychosis And Investigation Of Therapeutic Targets, Loren D. Peeters

Electronic Theses and Dissertations

Schizophrenia is a severe neuropsychiatric disorder of largely unknown etiology that is often accompanied by high rates of cigarette smoking, reduced quit success, and high relapse rates. Dysregulated dopamine signaling and aberrant synaptic plasticity in the mesocorticolimbic pathway are implicated in the pathophysiology of schizophrenia and conferred substance abuse disorder and relapse vulnerability. Genetic factors are presumed to play a significant role in the development of schizophrenia, with a 40-50% concordance rate for monozygotic twins, although genetic markers are inconsistent. As such, epigenetic factors have instead been implicated. Specifically, there is strong evidence to suggest DNA methylation at several candidate …

Groundswell, Ursula Gullow

Electronic Theses and Dissertations

The artist discusses the artwork of her Master of Fine Arts exhibition, Groundswell, held at Tipton Gallery in Johnson City, March 11 – 22, 2024. The exhibition includes wall pieces, sculpture, plaster, and ceramic objects that explore the traditional parameters of painting and its presentation.

Ideas discussed include the philosophy of history, and the origin of European art tropes such as odalisques, flowers, and birds. Framing devices, deconstructed paintings, fiber arts, ceramics, 18^th Century decorative art, plaster, the studio practice, Walter Benjamin, David Lowenthal, Gustave Courbet, Jean Honoré Fragonard, Titus Kaphar, Valerie Hegarty, and maximalism are also surveyed.

An Environmental Struggle: Nature’S Role In The Poetry Of Seamus Heaney And Robert Frost, Jake Lawson

Electronic Theses and Dissertations

Both New England’s Robert Frost and Northern Ireland’s Seamus Heaney are considered major poets of the 20^th century. Both poets present speakers who rely upon rural settings to explore troublesome feelings and difficult experiences. Their speakers project their human experience onto nature, but because nature is indifferent, they cannot find solutions for their personal discomfort and uncertainties. By examining the writers in this order—Ralph Waldo Emerson, Mary Oliver, Seamus Heaney, and Robert Frost—a spectrum concerning the poet and their relationship to nature emerges. By considering John Ruskin’s pathetic fallacy, we will see a movement from irrationality in transcendental depictions, …

The Beast In The Beauty: An Analysis Of Cultural Gender Biases And Stereotypes In The Classic Fairy Tale “Beauty And The Beast” And Implications In Modern Retellings, Lauren Lefler

Electronic Theses and Dissertations

This thesis looks at the fairy tale Beauty and the Beast to examine the way that this tale has been used throughout history to address the concerns of young women, as well as reinforce the culturally accepted gender roles of the time of their publication. The first chapter defines the fairy tale genre and features some of the most common criticism on the genre, it will then define and offer critical perspectives on the monster bridegroom motif which Beauty and the Beast is a part of. The second chapter will look at the first two publications of the text, the …

The Neoliberal Noirs Of Gary Indiana, Carson Morgan

Electronic Theses and Dissertations

This thesis is concerned with the two AIDS-era novels of Gary Indiana, a long-neglected yet essential literary figure who, as the critic Christian Lorentzen has argued, “connects the twentieth and twenty-first centuries in ways readers and critics are only beginning to apprehend” (xii). Beginning chronologically with a study of Indiana’s first two novels, Horse Crazy (1989) and Gone Tomorrow (1993), this thesis attempts to realize Lorentzen’s call to action, attending particularly to the ways in which Indiana’s novels write the neoliberal subject. More than exploring life under the AIDS crisis and embodying a radical queer approach to narrative, I contend, …

The Effects Of Text-Based Gaming On Reading Comprehension For Students With Intellectual Disability, Faith Ihrig

Electronic Theses and Dissertations

Since the COVID-19 Pandemic, reading comprehension and reading engagement have decreased in the United States. Our world is also becoming increasingly technological, and a large percentage of individuals in the United States, specifically children, are playing video games. There are increasing amounts of video games that target educational skills, such as reading and math, and video games that have been created strictly for entertainment. This study examined the potential effects of playing text-based video games on the comprehension and engagement of 6-8 grade students with intellectual disabilities. A Multiple Baseline Across Participants single case design was used to measure the …

Optimization Of Vagus Nerve Stimulation (Vns) And The Use Of Cervical Vns As A Treatment For Heart Failure With Reduced Ejection Fraction, Misty Owens

Electronic Theses and Dissertations

Vagus nerve stimulation (VNS) is a promising neuromodulatory therapy under investigation for a range of disorders, including heart failure, gastric dysmotility, and migraine. Two primary forms of VNS are currently investigated: cervical VNS (cVNS), involving surgically implantation to activate vagal afferents in the cervical branch in the neck and transcutaneous auricular VNS (taVNS) which subcutaneously stimulates the auricular branch in the outer ear. The nucleus of the solitary tract (NTS) serves as a relay-station receiving 90% of vagal afferents, enabling connections with higher-order brain regions and other brainstem nuclei like the spinal trigeminal nucleus (Sp5) and locus coeruleus (LC), facilitating …

Physiological Adaptations Following A Strength Endurance Training Block Performed With Accentuated Eccentric Loading Or Traditional Resistance Training, Alex Long

Electronic Theses and Dissertations

Physiological adaptations were investigated following a strength-endurance (S-E) block prescribed with accentuated eccentric loading (AEL) or traditional resistance training (TRAD). Recreationally trained participants (n = 11 males, 6 females, age = 23.2 ± 4.2 yrs, body mass (BM) = 81.3 ± 22.2 kg, height = 172.1 ± 10 cm) completed a four-week block of concurrent resistance, sprint, and change of direction training. Participants were assigned one of two training conditions, AEL (n = 9) or TRAD (n = 8). Training was identical, except AEL performed 110% eccentric overloading every 1^st, 3^rd, 5^th, 7^{th …}

P300 Event-Related Potential Responses To Self-Relevant Stimuli, Jordan Razzak

Electronic Theses and Dissertations

Previous literature has suggested an apparent P300 sensitivity to self-relevant stimuli. To further explore this relationship, we asked participants to submit 10 photos, each of a particular category (e.g. footwear, plants), to be used as either targets or distractors in a given condition of an oddball task. Furthermore, we attempted to see whether the effect of self-relevance on the P300 could be induced in a participant by allowing them to study a set of unique photos which would then be used as targets. Our analysis suggested that P300 amplitude elicited in response to self-relevant stimuli used as targets was statistically …

Exploring Available Information On The Gut-Brain Axis And Alzheimer’S Disease For Clinicians Making Dietary Recommendations: A Scoping Review, Megan Gibson

Electronic Theses and Dissertations

Abstract: Alzheimer’s Disease (AD) is a complex neurodegenerative disease that requires interprofessional collaboration. Pharmacological options are currently ineffective, increasing the need for preventative strategies to combat the rise of AD. Considerations of gut-targeted interventions have increased as a key component in the prevention of AD, based on the understanding that the state of the gut microbiome can impact cognitive function through the pathway known as the gut-brain axis.

Methods: This scoping review explored information on the gut-brain axis in persons with AD. A comprehensive search was conducted in November 2023. Forty reviews and 13 human studies were analyzed.

Results: There …

Beyond The Screen: Understanding College Students’ Perspectives On Cyberstalking, Gabrielle Jackson

Electronic Theses and Dissertations

Previous research regarding the victimization of college students is primarily geared toward physical or sexual encounters. There is a limited scope of research regarding the online victimization of college students, specifically those involved in Greek life organizations. Furthermore, there is a misinterpretation of the definition of cyberstalking among college students, as many students are unaware that they have been personally victimized (Cass, 2011). This study seeks to examine college students’ perceptions of online victimization and how they may vary. The different student impressions and the prevalence of online victimization were examined using self-reported data from students enrolled in a university …

Establishing “The Fossil Record”: A Database Of Vertebrate Paleontological Sites Across The State Of Tennessee, Sarah Mclaurine

Electronic Theses and Dissertations

Fossil localities across the state of Tennessee and the data related to those sites were compiled from Tennessee Division of Geology Bulletin 84, titled “Tennessee’s Prehistoric Vertebrates,” and stored in a Microsoft Access geodatabase housed by the Department of Collections at the East Tennessee State University Museum of Natural History located at the Gray Fossil Site. Included in the database are forms to enter new site localities, view information about those already entered, view and add data to a master faunal list for the state, view sites repository information and store and add documents that are key-word searchable from the …

Endo/Exo, Delaney Rogers

Electronic Theses and Dissertations

The artist, Delaney Shae Rogers, discusses her Master of Fine Arts exhibition, Endo / Exo, held at the Tipton Gallery in downtown Johnson City, TN. The exhibition dates are from March 25th through April 5th, 2024, with a public reception held April 5th, 2024. The author provides insight into the concept behind the work in the exhibition and shares how the making process and specific materials impact the work. This body of work explores coping with grief, anxiety, and the state of the world through the process of making and communicating otherwise difficult topics through visually digestible symbolic language.

Developing A Suitability Model And Feasibility Report For The Tennessee Mesonet, Tristan Holmes

Electronic Theses and Dissertations

Mesoscale networks, also known as Mesonets, are advanced environmental monitoring systems that consist of multiple high-quality weather stations that collect meteorological data at frequent intervals (5 minutes or less). Tennessee currently lacks a Mesonet system, and this study identifies suitable and feasible locations for stations in all 95 counties. Layers needed to develop the suitability model included land cover, road centerlines, elevation, flood zones, building footprints, and hydrologic soil types. Geospatial analysis techniques were used to process and combine these layers to identify suitable areas. Once suitable areas were determined, a feasibility assessment that examined land ownership, accessibility, and cell …

Ìlànà Òrí-Òkè Àtiyanrìn: T(H)Reading Sands And Mountains, Akintayo Akintobi

Electronic Theses and Dissertations

The artist presents his Master of Fine Arts exhibition, entitled Ìlànà Òrí-òkè Àtiyanrìn: T(h)reading Sands and Mountains. The exhibit was mounted in Tipton Gallery in downtown Johnson City, TN, from February 1 to February 9, 2024. The exhibition consisted of 13 artworks, including mixed media paintings, fibers, sculptures, and installations. In this thesis, Akintobi discusses his life experiences growing up in Nigeria and traveling to the United States for his MFA, and how these experiences have affected his art over the past three years.

Through the exhibition, the artist delves into the intersection and variances of cultural perspectives, exploring …

Illness Perceptions And Health-Promoting Behaviors: The Buffering Role Of Resilience In Adults With Congenital Heart Disease, Taylor Rose Eldridge

Electronic Theses and Dissertations

Congenital heart defects (CHD) are one of the most prevalent genetic abnormalities, impacting the lives of millions of children, teens, and young adults. Conservative diagnoses estimate that 2.4 million children and adults are living with CHD in the United States (Gilboa et al., 2016). CHD requires consistent cardiac support with multiple surgeries and hospitalizations expected throughout the lifetime, which significantly impacts psychological health. Specifically, patients present with a host of extra-cardiac conditions that impact their quality of life. With advancements in medical technology, mortality rates continue to improve for this population; however, individuals face a number of consequences that impact …

Harmonic Data: Ai Music, Edm Transcription, & Minimalist Jazz, Trevor Freed

Electronic Theses and Dissertations

This thesis presents research in the domains of music theory and music technology. The topics of the three chapters are as follows: (1) the technical and artistic limitations of artificial intelligence when generating music, (2) the transcription of electronic dance music (EDM) using a hybrid notation system, and (3) the effective convergence of jazz and minimalism in the music of Joe Hisaishi from Studio Ghibli. Each topic investigates a different aspect of harmony and the modern ways in which humans communicate in terms of harmony. The first chapter surveys the latest research projects in AI-generated music and proposes ideas for …

Cross-Institutional Collaboration And Exhibit Making: “On The Gold Mountain: Chinese Mining History And Heritage Of Idaho” At The Idaho Museum Of Mining And Geology, Jordan Kathleen Bennett

Electronic Theses and Dissertations

The Gold Rush, which brought many new immigrant communities to the American West, made a permanent impact on American culture by prompting the development of many Western towns. However, the Chinese immigrant mining population in the Boise, Idaho area has had little museum representation despite the more than 300,000 Chinese people who emigrated to the US between the 1840s and 1880. To rectify this, the Idaho Museum of Mining and Geology (IMMG), in collaboration with members of the Payette National Forest, the Asian American Comparative Collection, Boise State University/US Army Corps of Engineers, and the University of Denver, developed an …

Data-Driven Approaches For Enhancing Power Grid Reliability, Behrouz Sohrabi

Electronic Theses and Dissertations

This thesis explores the transformative potential of data-driven approaches in addressing key operational and reliability issues in power systems. The first part of this thesis addresses a prevalent problem in power distribution networks: the accurate identification of load phases. This study develops a data-driven model leveraging consumption measurements from smart meters and corresponding substation data to reconstruct topology information in low-voltage distribution networks. The proposed model is extensively tested using a dataset with more than 5,000 real load profiles, demonstrating satisfactory performance for large-scale networks. The second part of the thesis pivots to a crucial safety concern: the risk and …

#Getinked: An Anthropological Exploration Of Tattooing And Social Media, Delanee Taylor

Electronic Theses and Dissertations

This thesis aims to address two inquiries regarding contemporary tattooing. The first goal is to explore how social media has changed the practice of tattooing while the second goal is to examine how tattoos are used to express or explore the differing facets of a person’s identity. Identity theory, social identity theory, semiotics, and the concepts of stigma and deviancy form the theoretical framework which allows one to understand the ways in which tattoos can provide insights into the various aspects of someone’s identity as well as how social media can influence members of the tattoo community. An online survey, …

Social Identity And Self Determination: A Case Study Exploring What American Indian Elders' Perspectives Of Residential Boarding Schools Tell Us About The Lasting Effect Of Historical And Intergenerational Trauma, Jessica Boyer

Electronic Theses and Dissertations

Historically, American Indian youth have faced educational challenges due to the lack of American Indian perspective in history, culture, and knowledge in public education. Distrust in public education due to Eurocentric educational policy, addressed in this study that provides American Indian elders' experiences for finding solutions to self-identity for American Indian youth. Investigating the historical trauma barriers further addressed implications on the high-school retention of American Indian students. This qualitative case study involved a group of 10 elders, both men and women, who self-identify as Little Shell Chippewa American Indian Elders. Through semistructured interviews, the results of this study spoke …

Crosscultural Backchannelling Responses Among Second Language Learners, Chien-Hui Hsu

Electronic Theses and Dissertations

Backchannel responses (Yngve, 1970) have always been an essential component of conversational interactions that facilitate speaker-listener engagement and mutual shaping of narratives (Bavelas et al., 2000). This study aims to investigate the cross-linguistic difference in backchannelling responses between Taiwan Mandarin and English (General American) second language (L2) learners, and how those differences might impact communication in a cross-cultural classroom. The current study examines 20 participants, ten each from Taiwan Mandarin speakers and American English speakers. Each speaker was observed in an online conversation to eliminate the influence of non-verbal cues such as gestures and facial expressions. The backchannelling responses they …

The Metaphysics Of Creaturely Love In The Philosophy Of Anne Conway, Jeremiah Joseph Langer

Electronic Theses and Dissertations

A common belief during the early modern period held that humans bear ethical relations only to creatures with whom we share the right kinds of similarity. A tradition attributed to René Descartes holds speciesist and anthropocentric views according to which nonhuman animals are mere automata who lack rational minds. Even Baruch Spinoza, who was much more radical in his Ethics, suggests creaturely similarity is restricted to beings with rationality. As such, Descartes and Spinoza conclude that lower beings cannot be morally evaluated for their actions and humans cannot be morally evaluated for their treatment of lower creatures. In her sole …

Bigger Than Bees: Victorian England’S Relationship To The Bee – Considering Symbolism And Understanding, Grace Jacqueline Kaim

Electronic Theses and Dissertations

The complex and beautiful relationship the people in Victorian England had to the bee is one that goes beyond ideas of politics and religion. This thesis will explore this relationship by utilizing print, ephemera, jewelry, and household items, to demonstrate how the representation and symbolism of the bee was recognized and cherished by Victorians. While bees did certainly have an intimate relationship to the areas of politics and religion, one that is acknowledged throughout this work, their connection to grander themes of introspection, industrialism, folklore, morality, and status helps us understand the Victorians on a deeper level.

The Microbial Communities Of Freshwater Invertebrates And Their Influence On Biogeochemical Cycling, Stephanie Nicole Vaughn

Electronic Theses and Dissertations

Nutrient cycling in freshwater systems is primarily performed by microorganisms, however the interactions between microorganisms and other aquatic organisms such as macroinvertebrates is poorly understood. Interactions between macroinvertebrates and their associated microbial community, their microbiome, are important to understanding ecosystem functioning and guiding conservation efforts for imperiled macroinvertebrate species. In this study, I characterized the microbiomes of various freshwater macroinvertebrates and investigated the influence of sample storage methods and environmental parameters on these microbial communities. I first evaluated the impact of different sample preservation methods on the gut microbiome of two crayfish species, Procambarus vioscai paynei collected in the field …

Dixieland Do Sul: Brazilian Racial Democracy And The Recontextualization Of Transnational Confederate Symbols (Vol. 2), Maximilian Xavier Conrad

Electronic Theses and Dissertations

Following their defeat in the American Civil War, tens of thousands of American Southerners, many of them former Confederates, fled the United States to seek out new homelands in Latin America. Thousands would set their sights on Brazil, encouraged by the promise of arable land and the prospect of a new society in one of the hemisphere’s last slaveholding societies. Though many of these Confederados returned to the United States after Reconstruction, their influential presence in Brazil has remained a persistent factor. This thesis volume will focus on a semiotic struggle over the role of transnational Confederate symbols in the …

Impact Of Solar Radiation On Perchlorate Formation In The Atmosphere: Evidence From Ice Core Measurements, Bishnu Kunwar

Electronic Theses and Dissertations

Perchlorate, which derives from both anthropogenic and natural sources in the current environment, poses a substantial health hazard to humans as it competes with iodine uptake in the thyroid gland. Consequently, there has been considerable concern about minimizing human exposure to environmental perchlorate by restricting its release from man-made sources. However, the absence of a clear understanding regarding the respective contributions of man-made and natural sources has hindered widespread regulation efforts. A 300-year (1700–2007) Summit, Greenland ice core record from a previous study showed relatively stable perchlorate concentrations in Greenland snow prior to 1980, with some elevated perchlorate levels associated …

Primary Cilia And Intraflagellar Transport Are Essential Regulators Of Lymphangiogenesis And Modulate Cellular Trafficking Of Ve-Cadherin, Delayna Paulson

Electronic Theses and Dissertations

No abstract provided.