Digital Commons Network^™

The Effects Of Ethanol And Tributyrin On Alzheimer's Disease Pathogenesis In 3×Tg-Ad Mice., Lucy June Sloan

Electronic Theses and Dissertations

Alzheimer’s disease (AD) is a complex progressive neurodegenerative dementia with clinical hallmarks of amyloid-β plaques, hyper-phosphorylated tau in neurofibrillary tangles (NFTs), and neurodegeneration. Chronic, excessive alcohol consumption is associated with an increased risk for developing AD and other dementias. Both AD and chronic alcohol consumption are associated with dysbiosis in the gut microbiome (GM) characterized by a significant loss of beneficial butyrate-producing bacteria within the Firmicutes phylum. Previous studies demonstrate that chronic alcohol consumption accelerates AD pathogenesis in the 3×Tg-AD mouse model and that oral tributyrin (TB) supplementation in 3×Tg-AD mice reduces age-associated GM dysbiosis and AD-associated neurobehavioral deficits and …

Necessitating Autonomy: Performing Black Womanhood., Krystal Chavonne Waller

Electronic Theses and Dissertations

This thesis examines the ways in which Black womanhood should autonomously be represented on the stage and/or the screen. By defining the theories of Black Feminist Thought, Black Performance, Trap Feminism and Sankofa, I create a praxis that provides Black femme performers with tools for authentic characterization. By acknowledging and respecting that Black women are not monolithic, this thesis also explores the evolution of theatrical representations of Black Womanhood—particularly U.S. Black womanhood from the late 19^th century to modern day. Using historical narrative, analysis, acting techniques learned during my MFA program, and personal reflection, I advocate for Black women …

Applying Residence Time Distribution Theory To Coronary Thermodilution Curves., Jacob Michael Miller

Electronic Theses and Dissertations

Cardiovascular diseases remain the leading cause of death worldwide and coronary microvascular dysfunction is one cardiovascular disease which is particularly challenging to diagnose and treat. Coronary thermodilution is a widely used, invasive procedure to evaluate microvascular function by generating physiological indices such as coronary flow reserve and the index of microvascular resistance. Although commonly cited as an indicator dilution method in the cardiovascular literature, current coronary thermodilution techniques lack rigorous application of the accompanying mathematical framework, thereby leaving potentially valuable diagnostic information unexploited. This study bridges that gap by demonstrating the equivalence between indicator-dilution theory and residence time distribution theory …

Long-Term Changes In Bolus Parameters During Swallowing Post-Chemoradiation Treatment., Brittany Rebecca Smiley

Electronic Theses and Dissertations

Current treatment for oropharyngeal cancer involves chemoradiation, which can have profound effects on swallowing function. Submental muscle activity is critical for airway protection and bolus transit but is highly susceptible to radiation-related swallowing impairments. This study examined whether chemoradiation targeting the submental muscles leads to measurable changes in esophageal distension during swallowing in a rodent model. We hypothesized that rats receiving chemoradiation would exhibit aberrant esophageal distension compared to chemotherapy-only controls. Twenty male rats underwent four cycles of cisplatin concurrently with either radiation or sham radiation. High-speed videofluoroscopy swallow studies were conducted pre- and post-treatment with thin liquids to analyze …

Black Childhood In Focus: Counter-Histories Of Black Urban Childhood In Preserve The Baltimore Uprising, A 21st Century Digital Participatory Archive., Ameena Basheera X Ruffin

Electronic Theses and Dissertations

This study examines the (mis)representation of Black urban childhood in the United States and proposes a framework for Black children’s inclusion in historical narratives. Black children have been excluded from constructs of childhood innocence, justifying violence against Black children and perpetuating anti-Black social hierarchies. This study builds on the work of Saidiya Hartman, advocating for a critical approach to studying, archiving, and understanding Black childhood through the lenses of region, race, age, and gender. Using the participatory digital archive Preserve the Baltimore Uprising as a case study, the research explores Black children’s presence and contributions during the 2015 Baltimore Uprising. …

A Black Sherlock Holmes: An Exploration Of Nonconforming Characterization., Faith Janaye Artis

Electronic Theses and Dissertations

In the wake of diversity initiatives in the greater American theatre landscape, we are now including more Black actors than ever. Whether that be through the inclusion of diverse playwrights or implementing new casting protocols, we now have Black people in the room. However, when portraying the Black “version” of a character (i.e. Black Annie, Black Ariel, Black Juliet) a question still plagues the Black Actor’s mind: how am I meant to fit here? I evaluate my process of portraying Sherlock Holmes as my thesis role. By challenging the implied white perspective in this “universal” story (despite its feminist retelling), …

Cns-Specific Hiv Reservoir Characterization In Humans: Advancing Our Understanding Through Novel Genomics Methods., Ghazal Sadri

Electronic Theses and Dissertations

The persistence of the human immunodeficiency virus (HIV) reservoir despite years of suppressive antiretroviral therapy (ART) represents the principal obstacle to achieving a functional cure. Because the intact, replication-competent portion of the reservoir drives viral rebound after treatment interruption, HIV cure strategies must specifically identify and target cells harboring these proviruses. Conventional reservoir‐characterization techniques typically require separate assays to capture integration sites, assess proviral integrity, and quantify clonal proliferation and they rely on short‐read sequencing. These limitations hinder our ability to understand how integration landscapes, the integrity of the HIV genome, and cell‐division dynamics intersect to maintain viral persistence in …

Untitled: Study., Annabela Cockrell

Electronic Theses and Dissertations

Untitled: Study is an exploration into “The Work”, which is a constant evolution of the idea of the same piece. Every new work is an evolution of the one before. Previous works are often reworked and self-cannibalized into the next generation. The Work will never be presented the same way twice. There is a temporality in making and installing the work this way, what with the form, the space, the ness of it never being the same. All the while conflicting by being viewed as being the same in the same breath.

Mechanisms Of Particulate Hexavalent Chromium-Induced Inhibition Of Homologous Recombination Repair: Targeting The Bcdx2 Complex Considered Through A One Health Perspective., Aggie W. Brownell

Electronic Theses and Dissertations

Lung cancer remains the leading cause of cancer death, often linked to smoking. However, smoking alone does not account for all cases. Exposure to environmental metals like hexavalent chromium [Cr(VI)] also contributes to lung cancer. Cr(VI) causes lung cancer by inducing chromosome instability (CIN), an early hallmark of its carcinogenic mechanism. While it has been established that Cr(VI) induces chromosome instability, the precise mechanisms underlying the chromosome instability are poorly understood. This dissertation investigates the mechanisms of carcinogenesis associated with zinc chromate, a particularly potent particulate form of hexavalent chromium. Studies show Cr(VI) induces DNA double-strand breaks and impairs the …

Investigating Stress Hormone Variations In Green Frogs (Lithobates Clamitans) During The Mating Season, Abby Mciver

Electronic Theses and Dissertations

Monitoring stress hormones in wildlife populations is increasingly used to understand how human activities may impact the environment. The goal of this study was to quantify corticosterone in green frogs (Lithobates clamitans) at baseline levels and in response to an acute stressor throughout the mating season. The project was conducted from May to September of 2024 at Bays Mountain Park in Kingsport, Tennessee. Corticosterone levels were determined over six consecutive days each month from May to September using a non-invasive dermal swab technique. Additionally, body metrics, water chemistry, and weather and habitat conditions were evaluated on each sampling …

Investigating The Effect Of Fasting On Senescent Cells In Nothobranchius Furzeri Fish, Israel A. Akinola

Electronic Theses and Dissertations

Senescent cells (SCs) have been documented to accumulate with age in the organism. Recent studies have shown that reducing the number of SCs in an organism result in tissue rejuvenation and extension of life expectancy. Intermittent fasting is reported to have multiple health benefits and is speculated to reduce the burden of SCs. Nothobranchius furzeri are a new model organism for studying aging and for which there are short- and long-lived strains available. We hypothesize that long- and short-lived strains of N. furzeri will accumulate SCs at different rates; and that fasting will reduce the burden of SCs.

The results …

The Scream Notation System: A Notational System For Screamed Vocals, Matthew Delcambre

Electronic Theses and Dissertations

In Western music notation, there is no specified system of notation for screamed vocals, a style of singing that has become increasingly popular since the late 1970s with the advent of metal music and seen increased interest in screams in other genres since. Screams are a unique and diverse vehicle of delivery that can be differentiated according to timbre, technique, pitch and physiology. This research aims to first identify the anatomical and timbral differences between named screams and create a database of screams to be studied. The next task is to design a notational system appropriate for screams and then …

Angelic Wasting: The Impacts Of The Enlightenment, Evangelicalism, And The Industrial Revolution On Romanticization Of Tuberculosis In England, 1800-1850, Sara M. Sudano

Electronic Theses and Dissertations

This thesis aims to elucidate the intersections between the portrayal of tuberculosis in the Romantic era and the Enlightenment, evangelism, and the Industrial Revolution. This study aims to do so by locating and analyzing depictions in the primary source representations of the disease, then considering the effects of the three factors mentioned above on its representation. The Enlightenment, evangelism, and the Industrial Revolution interacted in a variety of ways, and the influence of all three factors was found within the representations of tuberculosis, albeit in often indirect ways. In the novels of Elizabeth Cleghorn Gaskell and Charlotte Brontë, tuberculosis was …

Initial Impacts Of Different Fertilizers On Improved East Texas Equine Pastures, Carolina De Leon, Brian Oswald, Leland Thompson, Candis Scallan

Electronic Theses and Dissertations

ABSTRACT

In Texas, approximately 1.6 million acres support an equine population exceeding 748,000 horses. This study assessed the effects of organic and inorganic fertilizer treatments on improved Bermudagrass (BG) and other vegetation (OTH) in overgrazed equine pastures at the Stephen F. Austin State University Equine Center. Treatments included equine manure (H), broiler poultry litter (P), and a commercial 13-13-13 fertilizer (C), with application rates based on pasture requirements.

Initial vegetation cover was evaluated using the Daubenmire cover class method in September 2024, followed by a 60-day undisturbed growing period. Final biomass (g/2ft² converted to lbs/ac) and percent cover measurements were …

Interdisciplinary Collaboration: The Impact Of Curriculum Support Through Museum/Education Partnerships In Rural Communities, Erin Gentry

Electronic Theses and Dissertations

Museum education is a dynamic field, and often an underutilized or nonexistent resource in the educational sphere of rural communities. Within the current system of rural K-12 schools, a local museum can serve as both educational enrichment and entertainment/reward. The author’s research explores how museums in rural communities can actively collaborate with schools through a fusion of art and science using an interdisciplinary curriculum model to provide educational support and enrichment to both students and teachers. This research focused on high school students enrolled in a Title 1 charter school located within a rural district in east Texas. The author …

Movement Ecology Of Sandhills Chub, A Carolina Endemic, Zachary Adam Ramsey

Electronic Theses and Dissertations

Fish movement studies have traditionally focused on species that support commercial and recreational fisheries, but recently more focus has been given to non-game, stream fishes because of their recognized importance in maintaining biodiversity within these ecosystems. Stream fish movement is described as being “restricted” and following a leptokurtic distribution via diffusive spread related to environmental and biological factors. Many studies of stream fish movement ecology in North America have occurred in high-gradient streams with coarse substrate in mountains or in streams of the interior plains. Sandhills streams of the southeastern USA are characterized as warm-water, low gradient, and dominated by …

Flow Field Surrounding Bluegill (Lepomis Macrochirus) During Suction-Feeding, Jensine Caroline Coggin

Electronic Theses and Dissertations

Suction-feeding is a common method for capturing prey by aquatic organisms and contributed to the diversification of fishes by enabling them to consume a wide range of prey. Suction-feeding is a complex fish-fluid interaction governed by various hydrodynamic forces: inertia, unsteady, viscous, and pressure gradients. These forces are described by the coupling between the flow physics equations (Navier-Stokes) and the dynamic behavior of the fish (motion and forces). However, the distribution of the pressure field that drives this process, and the extent to which suction-feeding is three-dimensional, remain underexplored. I estimated the pressure within the flow field surrounding the mouth …

Heterotopias Of Confinement: Zoo Architecture And The Loss Of Elephant Agency, Clayton Gill Beasley

Electronic Theses and Dissertations

Zoos functions as a site where human-animal relationships are structured through built environments that mediate control and representation. This study examines zoos as heterotopias—spaces where power and surveillance are negotiated between human observers and captive nonhuman animals. While zoos are often framed as spaces of conservation and education, their architectural design reinforces hierarchies of observation and confinement, shaping both human perceptions of nature and the lived experiences of nonhuman animals. This research focuses on Asian elephants as a critical species within this framework, exploring how their captivity illuminates tensions between human-imposed structures and nonhuman autonomy. Drawing from theories of heterotopia, …

Leveraging Ai For Enhanced Multimedia Content Creation: College Students’ Perception On The Innovation, Georgina Amankwa

Electronic Theses and Dissertations

Artificial Intelligence (AI) has revolutionized multimedia content creation, enhancing efficiency and personalization. However, this rapid evolution has raised concerns about originality and ethical responsibility. This study explored college students’ perceptions of AI in content creation and its implications. Using a mixed-methods approach, the research combined surveys and qualitative insights to analyze how students engaged with AI tools. Findings revealed that while AI streamlined workflows, improved content quality, and boosted audience engagement, concerns about authenticity, intellectual property, and the diminishing role of human creativity persisted. Statistical analyses showed a strong correlation between frequent AI use and perceived benefits, yet ethical dilemmas …

Evaluating The Relationship Between Musical Sophistication And Melodic And Harmonic Expectations., Anya Elizabeth Shorey-Smith

Electronic Theses and Dissertations

Expectations help us navigate our environment, especially in familiar contexts. Western tonal music offers one such context where expectations are at play. While implicit musical expectations occur in listeners without musical training, musical training can sharpen expectations. Two primary open questions are investigated here. First, explicit pitch-based expectations for less musical participants have been relatively neglected. Second, general musicality and formal musical training have not been well separated in previous research, making it difficult to understand if sharpening of expectations is associated with training itself or with broader musical interactions. Experiments 1 and 2 adapted an explicit music production task …

Translation Of The Carcinogenic Dna Breakage-Repair Inhibition Mechanism For Hexavalent Chromium To Its Key Targets: Lung Epithelial Cells, Lung Tissue And Impacts On The Genome., Idoia Meaza Isusi

Electronic Theses and Dissertations

Lung cancer is the leading cause of cancer death worldwide. Hexavalent chromium [Cr(VI)] is a human lung carcinogen with widespread occupational and environmental exposure. Despite the known health risks, how Cr(VI) causes lung cancer remains unclear. This dissertation investigates the mechanisms of Cr(VI)-induced carcinogenesis. Cr(VI) causes DNA damage, specifically DNA double strand breaks, and inhibits homologous recombination repair, a high-fidelity repair pathway. Unrepaired DNA double strand breaks or those repaired through error-prone pathways, progress to chromosomal damage, and chromosome instability. The latter is a common characteristic of Cr(VI)-exposed cells, and a hallmark of lung cancer. Although the mechanism of Cr(VI)-induced …

The Effects Of Geographic Isolation And Anthropogenic Activity On The Social Behavior Of Caribbean Green Monkeys., Rose Amrhein

Electronic Theses and Dissertations

Green monkeys (Chlorocebus sabaeaus) arrived to the Caribbean with the Trans-Atlantic slave trade. Since then, they have experienced unique environments to those of their native ranges in West Africa. Additionally, recent taxonomic changes within the genus make previous knowledge about the species hard to determine to be accurate. In this dissertation, I both assess some of the effects the island environment may have had on monkey behavior as well as build on the understanding of their vocal communication across three islands: Barbados, St. Kitts, and St. Martin. In chapter one, I investigate how human activity in Barbados affects …

Sars-Cov-2 Modulates Pla2g2d/Pgd2 Signaling To Manipulate Host Immune Response To Increase Disease Severity., Dante L. Hamiel

Electronic Theses and Dissertations

Background: Previous studies suggested that SARS-CoV-2 infection could cause diverse immune and metabolic dysregulations, although the underlying mechanisms remain poorly understood. In addition, viruses may escape the immune response by modulating cellular metabolism, mitochondria, and protein functions indicating that immune or metabolic components may represent novel targets for anti-viral strategies. However, whether immune and metabolic disorders interact or affect each other waits to be determined. On the other hand, previous investigations identified the critical roles of a cell membrane-bound phospholipase PLA₂G2D and its downstream products PGD₂ in regulating the metabolism and inflammation in respiratory system. More importantly, …

Tel Jezreel's Medieval Crusader Cemetery: A Case Study In Contemporary Burial Practices And Necroviolence Against Infants And Children., Autumn Koehling

Electronic Theses and Dissertations

The 1990s excavation of the archaeological site of Tel Jezreel in the modern nation state of Israel yielded the remains of fifty infants and children, associated with the contemporary Medieval Crusader Church. The Church, built by Knight’s Templar from the Frankish Kingdom served the occupants of Tel Jezreel from the 11^th to the 13^th century and introduced Western Christian burial practices to the local Syriac-Palestinian Christian inhabitants. Burial practices from the surrounding region of the Levant and beyond, into Crusader European cultures, show different forms of burial treatment for infants and children that can be used to understand …

The Voices Behind The Screen: Navigating The Politics Of Work-Time, Identity, Visibility, And Tokenism In The Workplace., John Douglas Broadus Jr.

Electronic Theses and Dissertations

The COVID-19 pandemic has and continues to impact labor and work in numerous ways. As organizations began to adjust to the changes the COVID-19 pandemic brought on to how they operated, there arose a considerable amount of conflict regarding what work is and what work should be. Conflicts arose around issues of work/life balance, work-hour mismatch, health and wellbeing, self-autonomy, and individual vs. collective work, influencing how employee sees themselves, their work, and their role within the organization. This research study will focus on the culture of “work time” that is present within a public-sector organization and the various ways …

Inferring Feeding Biology In Extinct Shrews (Soricidae: Mammalia): Application Of A Linear Morphometric Approach, Derek J. Den Ouden

Electronic Theses and Dissertations

Linear morphometrics have been used extensively to infer the ecology of fossil organisms, but shrews have not yet been thoroughly explored using this technique. Often considered to have a homogenous insectivorous diet, direct dietary observation suggests shrew dietary diversity is substantial. Diversity of this nature is well established to have influenced skull morphology in other mammal clades, so similar patterns are hypothesized to be detectable in shrews. To test this, I examined the link between known diet and morphological disparity in extant shrews using linear morphometrics and then utilized that framework to infer the dietary ecology of several fossil taxa. …

Assessing The Relationship Between The Incidence Of Campylobacteriosis And Ecological Risk Factors In Tennessee, Emmanuel Angmorteh Mensah

Electronic Theses and Dissertations

Background: Campylobacteriosis although is the leading causes of bacterial diarrheal illnesses, have not gained prominent awareness and there are gaps in the understanding of transmission routes for sporadic, non-outbreak cases and their risk factors at the communal level to humans. This study, therefore, aimed to identify the campylobacteriosis risk factors and risk perception from the existing literature in the United States, determine the incidence and ecological risk factors for campylobacteriosis zip code level in Tennessee, and to perform spatiotemporal analysis of campylobacteriosis incidence cases in Tennessee.

Method: To achieve the first aim, a scoping review was conducted to synthesize …

The Moderating Role Of Social Support For Lgbtq People In South Central Appalachia: Present Yet Unimpactful?, Paige Henry

Electronic Theses and Dissertations

Lesbian, gay, bisexual, transgender, and queer (LGBTQ) minority stress theory states that LGBTQ people experience stressors specific to their identity that result in negative mental health outcomes. Social support has been shown to protect against these negative outcomes, but South Central Appalachia is known to be high stigma and low resource for this population. The present study examined the potential moderating impact of four sources of social support (family, friends, partners, and pets) on the relationship between minority stress experiences and psychological distress for LGBTQ people living in South Central Appalachia. Participants included 116 LGBTQ adults living in South Central …

The Forest Through The Trees: Modeling The Ecological Niche And Potential Assemblage Distribution Of Oak-Hickory Forests Across The Eastern U.S., Elijah Worley

Electronic Theses and Dissertations

Understanding how tree species’ ranges and populations may shift by the end of the 21^st Century is critical for effective conservation and forest management. Ecological niche models are widely used to predict species distributions by modeling the relationships between environmental variables and species presence. While numerous models have been developed for individual tree species across the USA, there is limited research on how tree species assemblages, such as oak-hickory forests, will respond to changes in climate over time. Maxent modeling software was used to predict potential shifts in suitable habitat for the oak-hickory forest type, based on environmental variables …

Unraveling The Unknown: Characterization Of A Novel Antimicrobial Compound Found In Klebsiella Pneumoniae, Jasmal Cruz Perez

Electronic Theses and Dissertations

Klebsiella pneumoniae, a pathogenic bacterium resistant to numerous antimicrobials, is a worldwide health issue due to its ability to cause healthcare-associated diseases such as pneumonia and urinary tract infections. This study investigated an antimicrobial compound secreted by K. pneumoniae. The compound was found to possess inhibitory activity against Enterobacteriaceae members, including other Klebsiella pneumoniae strains, Citrobacter freundii, and Enterobacter cloacae. The inhibitory activity is mediated via a secreted protein that is active across a wide range of pH and temperature conditions. Higher concentrations of the compound enhanced antimicrobial activity. The antimicrobial protein suppressed biofilm formation during both …