Digital Commons Network^™

The Impact Of Estrogen Loss On Caveolin Expression And Cardiac Myocyte Remodeling In Ovariectomized Mice Following Chronic Sympathetic Stimulation, Juliana Barnie

Electronic Theses and Dissertations

Cardiovascular disease (CVDs) remains the top cause of death globally, with postmenopausal women at higher risk due to estrogen decline. Beta-Adrenergic (β-AR) signaling is a major regulator of heart function. Caveolins, structural proteins of caveolae, coordinate cell signaling activities in the heart by co-localizing with estrogen receptors and β-AR and contribute to maintaining healthy cardiac function. The caveolin scaffolding domain (CSD), a binding component of caveolin, has shown therapeutic potential in animal models of heart disease. However, most studies on CSD have been completed in male mice. This thesis evaluates the therapeutic potential of CSD in female mouse models and …

The Lived Experiences Of Navajo Nurses During The Covid-19 Pandemic, Stephnie Ann Leeson

Electronic Theses and Dissertations

When COVID-19 was diagnosed on the Navajo Nation, the impact on the people and the healthcare system was not understood. For almost three years, Navajo healthcare workers battled what was known to the Navajo as Dikos Nitsaaígíí Náhást’éíts’áadah, translated as The Big Cough. The Navajo Nation President, Jonathan Nez, referred to it as a Monster, as did many people in the Navajo Nation. Navajo nurses on the frontlines battled the monster daily as they saw friends and relatives succumb to the insidious disease. Much has been written about nurses off the reservations working on the frontline during the pandemic. However, …

Role Of Cellular Proteins In The Regulation Of Herpes Simplex Virus Type 1 Gene Expression And Dna Replication, Joseph R. Heath

Electronic Theses and Dissertations

Herpes simplex virus type 1 (HSV-1) is a ubiquitous human pathogen that infects the majority of the human population. To facilitate infection, this virus relies on a combination of host and viral factors. Previous studies have revealed a number of host proteins that associate with the HSV-1 genome throughout infection but their putative role(s) in this process remain undefined. This study aims to examine two such proteins to determine their contributions to HSV-1 gene expression and DNA replication. The first of these factors is Ints3, a subunit of the Integrator complex. This protein complex functions in transcription regulation, and Ints3 …

The Islamic Orient In Antebellum America: The Influence Of Edgar Allan Poe In Contemporary Arabic Literature, Sohaib Alkamal

Electronic Theses and Dissertations

This dissertation posits a comprehensive overview of the debate about Orientalism, particularly early American depictions of the Islamic Orient. The study investigates the antebellum American portrayal of the Islamic Orient, focusing on Edgar Allan Poe’s Orientalist readings. While Said’s Orientalism concentrates heavily on aspects of power in West-East relations throughout history, this study expands on several aspects of Said’s book. This study provides a new approach to exploring the field of Orientalism by giving a voice to Arabic sources that are absent in Said’s Orientalism and rarely known to Western audiences. Such sources are medieval Islamic sources, which include phantasies …

Political Ecologies Of The Livestock Industry, Jecca Bowen

Electronic Theses and Dissertations

In the United States today, livestock production is dominated by an intensified, industrialized production paradigm whose growth in recent decades has utterly transformed the logistical realities and community impacts of animal agriculture. This dissertation investigates the effects of this production paradigm on livestock producers—whose decision-making is shaped by multi-scalar and often contradictory forces—as well as residents living near these large operations. To do so, I draw upon mixed-methods fieldwork, including in-depth interviews, spatial analysis, and field odor measurements in Weld and Morgan Counties in northern Colorado. I also use political ecologies of emotion, embodiment, and health to examine the complex …

The Role Of Imagination In Archaeology: Linking Contemplation And Method At The Amache National Historic Site, Sami Zepponi

Electronic Theses and Dissertations

Archaeology is both a science and an interpretative process, blending material discovery with imagination to reconstruct past experiences. This research, conducted through the 2024 University of Denver Amache Field School, explores the archaeological imagination and the creative and cognitive engagement that shapes historical interpretation. Using Amache, a WWII Japanese American incarceration site, as a case study, this thesis examines how material culture, landscape modifications, and reflection inform archaeological understanding. This study explores how imagination connects tangible findings to cultural narratives by integrating community-based archaeology, place and landscape theory, and contemplative inquiry. Findings highlight imagination as essential to archaeology, enabling deeper …

Cultivating Resilience In The Anthropocene: Evaluating A Gssw Ecological Justice Curriculum, Windy Selig

Electronic Theses and Dissertations

This Dissertation in Practice evaluated the University of Denver’s Graduate School of Social Work (GSSW) Ecological Justice Pathway to examine how resilience is conceptualized and cultivated within the curriculum. Grounded in a constructivist paradigm and guided by an ecological justice framework, this evaluation explored the pedagogical and curricular strategies designed to prepare social work students for the emotional, ethical, and professional demands of practicing in the Anthropocene—a time marked by ecological degradation, climate crisis, and compounding social inequities.

Through qualitative methods, including faculty interviews and curriculum document analysis, the evaluation identified both explicit and implicit components that foster student resilience. …

Margaret Cavendish And Radical Self-Love, Marina Burandt

Electronic Theses and Dissertations

Margaret Cavendish was an early modern Englishwoman writer who lived from 1623 to 1673. She wrote under her own name at a time when it was more common for women to write under a pen name, and published almost everything she wrote. Her writings include a multiplicity of genres, from science fiction, poetry, drama, and philosophy, to letters, biography, and autobiography. Cavendish’s style often blends multiple genres and forms, showcasing a modality that is driven by complexity and hybridity. Cavendish was a surprisingly modern figure in many ways, as her writings show. The Description of a New World, Called the …

The Shōnen Apocalypse: An Analysis Of The Shōnen Power System And Its Narrative Functions, Mario Da Silva Melo

Electronic Theses and Dissertations

My thesis has two primary goals. First, it provides an overview of the history of manga as a medium, and manga studies as a field. In doing so, I observe a lack of terminological and methodological specificity. As a result, I provide a formalist approach to thematic criticism in order to address the above issues. Second, my thesis primarily centers on shōnen power systems and their narrative functions. Power systems are "magic rules" that determine how superhuman abilities mechanically function. I identify two main power systems in shōnen manga: spiritual manipulation and transformations. My thesis posits that shōnen manga authors …

The Narratological Maus, Isla Lader

Electronic Theses and Dissertations

The Complete Maus, a memoir graphic novel surrounding the events of character Art Spiegelman as he collects, records, and illustrates his father’s life pre-the Holocaust in Europe, his time in Auschwitz, and then life in the United States has been one of the focal Holocaust survivor testimonies and has redefined the genre it exists in as both a graphic novel, but also as a form of testimony. Like many popularized works dealing with the Holocaust, though, cultural preconceptions of Jewish people, genocide, and audiences’ desire to find morals within the work have made it so often audiences come to …

E Ho’Omau Mākau, We Will Continue: The Living Sovereign Entities Of Contemporary Hawaiian Songs, Kēhaulani Lagunero

Electronic Theses and Dissertations

This thesis examines the relationship between contemporary Hawaiian mele (songs) and Hawaiian ea (sovereignty), focusing on how mele acts as sovereign living entities representing cultural resilience, identity, and resistance to settler-colonial influences. Through semi-structured interviews with Kānaka Maoli, participant observation at cultural events, and close analysis of mele, I identify that these songs are not only expressions of cultural memory, but also living embodiments of ea—sovereignty because they are alive, and they are alive because they are ea. Drawing from the frameworks of cultural survival, survivance, symbolic power, and defiant indigeneity, I explore how mele actively engage …

Exploring New Mexico 4-H Volunteers’ Acceptance And Use Of Technology: A Qualitative Approach, Kayla Dawn Hinrichs

Electronic Theses and Dissertations

Integrating technology into youth development programs like 4-H is increasingly vital for enhancing communication, education, and engagement. However, technology adoption among 4-H volunteers remains inconsistent. This qualitative study explored the barriers to technology adoption among New Mexico 4-H volunteers. The researcher aimed to understand the factors influencing their willingness and ability to integrate digital tools into their volunteer roles. Guided by Rogers’s (2003) diffusion of innovation theory and framed by Creswell and Poth’s (2024) qualitative research design, this study employed semistructured interviews with a purposive sample of 4-H volunteers across the state. Following Braun and Clarke’s (2006) six- phase approach, …

Rhetoric Of Soft Power And Public Diplomacy A Case Study Of Saudi Arabia, Sihmy Algamedi

Electronic Theses and Dissertations

Soft power is the capacity to exert influence over the actions of others in order to accomplish one's goals. It refers to the ability to influence others without seeking any tangible benefits. Soft power emanates from a country's cultural, political beliefs, and foreign policies. Soft power refers to the capacity to achieve desired outcomes using methods that involve shaping the agenda, employing persuasion, and generating positive appeal (Alkatheeri, and Khan 26). In order for this endeavor to achieve success, the concept of legitimacy plays a pivotal role in the effectiveness of soft power. Public diplomacy is a component of foreign …

Feasibility Analysis For The Implementation Of An Anaerobic Digestion System In The City Of Pittsburgh, Pa, Gianna L. Kolencik

Electronic Theses and Dissertations

The current study is investigating the feasibility of an anaerobic digestion system

in Pittsburgh, Pennsylvania, at the old State Correctional Institute (SCI-Pittsburgh)

located at 1922 Westhall St. This location is immediately upstream of the Allegheny

County Sanitary Authority (ALCOSAN) along the Ohio River. Municipal solid waste

from ALCOSAN may be used as the main form of feedstock. ALCOSAN produced

roughly 36,500 tons of dry sludge in the reporting year 2023-2024. Based on the volume

of dry sludge from ALCOSAN it is estimated that an anaerobic digestion system could

yield approximately 29,930,000 kWh of energy, which is enough to power over …

Computational Models Of Vocal Fold Lesions: Analysis Of Fluid-Structure Interaction, Manoela Rocha Neves

Electronic Theses and Dissertations

The biomechanical and aerodynamic behaviors of the vocal folds (VFs) during phonation are heavily influenced by their structural composition and pathological changes. These conditions can induce localized stiffening that disrupts vibratory symmetry and alters airflow resistance. Previous research has lacked the integration of VF lesions in computational simulations using anatomically accurate models, limiting the understanding of their effects in phonation and potential contribution to voice disorders. Addressing this gap, this thesis develops a fluid-structure interaction (FSI) model of a realistic two-layered VF structure with lesions, comparing airflow patterns, structural deformations, and vibration profiles in both healthy and diseased cases.

The …

Impact Of Unconventional Gas Extraction On Tributaries Of Tenmile Creek, Greene County, Pennsylvania: A 12-Year Perspective, Christian L. Beall

Electronic Theses and Dissertations

Much of southwestern Pennsylvania has been central to a rapid increase in development for unconventional natural gas extraction in the past two decades. The continued monitoring of streams over their lifetime as extraction sites is pivotal to understanding the effects of fracking on local waterways and their ability to provide for wildlife and human use. Here, using multiple indices of biotic integrity (IBI), I perform analyses of fish and macroinvertebrate communities as well as water chemistry on two streams, Bates Fork (with shale wells) and Fonner Run (without), as part of a follow-up to work performed there from 2010-2012. Fish …

A Raced Theology Of The Human Person: An Expanded Theological Anthropology, Cary W. Dabney

Electronic Theses and Dissertations

This dissertation focuses on race as a critical, yet largely unaddressed, topic in Catholic theological anthropology. In Catholic colleges and universities that are recognized as members of the Cardinal Newman Society, theological concerns about race are deemed irrelevant for theological education in the faith and are altogether absent from the theology of the human person. As a result, this collection of institutions treats race as a specialty within pastoral theology, one that is significant to groups, but not a part of the fundamental theology of the human person. This ‘un-raced’ theological anthropology results in the institution’s inability to respond effectively …

The Contribution Of Catholic Compromise Principles In Global Health, Scott N. Helstad

Electronic Theses and Dissertations

The Roman Catholic tradition has developed comprehensive ethical principles to address complex practical scenarios that encounter foundational value compromises. These are referred to as compromise principles and they have both a narrow and a broad focus. Narrowly, these compromise principles are critical for Catholic healthcare organizations in the United States with regard to the guidelines of the US Bishops in their Ethical and Religious Directives for Catholic Health Care Services. More broadly, these compromise principles are relevant in the secular realm regarding global health. This dissertation examines these varying perspectives, hence its title, “The Contribution of Catholic Compromise Principles …

Kenneth Burke's Epideictic Rhetoric Of Science, Andri Kosasih

Electronic Theses and Dissertations

This dissertation addresses Kenneth Burke’s challenges, notions, and perspectives on modern science and how we should view, utilize, and apply science to our lives. This project argues that we need more than the rhetoric of science; we need an epideictic rhetoric of science. The term epideictic is important because the encounter between science and society creates a tension between maintaining and changing beliefs. Because science involves belief and is itself a belief, every time we engage with science, it demands a verdict from us: to believe or to reject it. On the other hand, as we seek to maintain our …

Demography Of Alligator Snapping Turtles (Macrochelys Temminckii) Along A Fishing Pressure Gradient, Luke T. Micek

Electronic Theses and Dissertations

Passive fishing gear is a threat to the alligator snapping turtle (Macrochelys temminckii). The spatio-temporal persistence of this threat and its impacts on M. temminckii populations has not been quantified. I quantified the density of passive fishing gear and the demographic parameters of M. temminckii along a fishing pressure gradient in East Texas streams. Most gear was abandoned and illegally deployed, with densities varying seasonally. Detectability of passive fishing gear declined with increasing gear age, water depth, and volume, but increased with increasing precipitation. Macrochelys temminckii catch per unit effort, abundance, and survival was lower at sites with …

Evaluating Predictive Models For Predicting Total Score Of Beef Carcasses, Emmanuel Forson

Electronic Theses and Dissertations

The beef industry plays a vital role in global agriculture, with carcass quality and consumer preference being key determinants of market success. This thesis examines predictive modeling techniques for estimating the Total Score of beef carcasses, a composite measure representing yield and quality, primarily used by the Nebraska Cattlemen Association. Using data from the Nebraska Cattlemen’s Foundation Retail Value Steer Challenge (2000–2023), the study compares the performance of First Order Multiple Linear Regression (MLR) with three machine learning techniques: K-Nearest Neighbors (KNN), Random Forest, and Gradient Boosting Machine (GBM).

The analysis focuses on six key predictors: Hot Carcass Weight, Back …

Thresholds, Dagon Blank

Electronic Theses and Dissertations

Thresholds focuses on liminal spaces, moments of change, and those who cross these boundaries. For instance, transitions from the old to the new, unconscious to conscious, the known to the unknown, or where man meets nature. Sometimes, I think of them as a threshold where both sides are trying to cross simultaneously, but the door is only big enough for one to fit. The scenes in these paintings focus on the figure set in the contemporary world, referencing symbols of classical paintings, mythology, and philosophy.

The scenes are dynamic and driven by the expressiveness of the human figure and the …

Swine Solutions: Enhancing Ffa Supervised Agricultural Experience Projects, Hannah M. Daily, Dr. John Michael Mehaffey, Dr. Candis Scallan, Dr. Amy Mehaffey, Dr. Joe Mask

Electronic Theses and Dissertations

Supervised Agricultural Experience (SAE) is a portion of the three-circle model of agriculture education, providing experiential learning opportunities for students. The immersion SAE encourages students to build upon foundational learning components in a real-world application. A popular area of the immersion SAE includes ownership of market swine being raised for exhibition. This study serves as a pilot mentorship program for agricultural science educators and students, creating an educational resource encouraging record-keeping techniques and skill development, leading to eventual independence from the student’s standpoint. The model for the Swine Solutions Program includes utilization of the provided handbook, completion of daily observation …

On The Deconstruction Of Nothingness In Digital Communication, Matthew S. Lindia

Electronic Theses and Dissertations

This project argues that digital technologies call for a new problematic of communication, centered around the conditions of (im)possibility for creating perfect digital profiles of users as generated from user data. Beginning with Edmund Husserl’s analysis of essentially occasional expressions, this dissertation posits that user data occurs on three levels: (1) the level of expression, where a user wants-to-say something through their inputs, (2) the level of facticity, where biometric data are involuntarily produced by the user, and (3) the level of nothingness, where the user’s inaction, such as not-answering, is taken as data. Moving beyond what Husserl’s framework can …

Tracing Clovis Landscapes: Chert Sourcing At The Copelin Valley Site In Kentucky., Shaylee Scott

Electronic Theses and Dissertations

This study conducts a raw material sourcing analysis of Clovis lithic artifacts from Copelin Valley, Hart County, Kentucky, a key Clovis occupation site. Over a decade of documenting private collections and recent archaeological investigations confirm the site's significance within the Paleoindian landscape. Using reflectance spectroscopy, a non-destructive technique, this research assesses chert source probabilities for over 100 Clovis points and tools. By integrating spectral data with geological sourcing frameworks, this study examines raw material procurement strategies and their implications for Clovis mobility and settlement. The findings reveal patterns in material selection, shedding light on occupation intensity, technological organization, and landscape …

Advancing Research On Retinitis Pigmentosa: An Investigation Of Natural History, Visual System Plasticity, And Mutation-Independent Treatment., Cecilia A. Attaway

Electronic Theses and Dissertations

Retinitis Pigmentosa (RP) is an inherited retinal disease characterized by rod and then cone photoreceptor degeneration. ~25% of cases are caused by a genetic mutation that results in autosomal dominant RP (adRP). There has been a lack of exploration of the progression of degeneration in adRP models. In Chapter Two, I examined visual acuity (VA) changes, retinal structure, and function from early to late-stage disease in a murine P23H Rho ‘knock-in’ mouse model (Rho^P23H/+), the most common form of adRP in North America. To establish a natural history, I evaluated behavioral VA, using the visual water task, …

“Souls Cannot Rest In Contested Places”: An Ethnographic Case Study And Archeological Environmental Assessment Of The North Shore Cemeteries., Henrietta K. Ransdell

Electronic Theses and Dissertations

This thesis is an ethnographic case study and archeological-environmental assessment of the North Shore Cemeteries to derive condition commentary and care recommendations for the landscape, cultural resources, descendant community, and Great Smoky Mountains National Park. Framed by theories of space-place culture, dispossession, and public lands co-management, this multi-methods, interdisciplinary thesis combines historical context, environmental conditions, archeological documentation, participant observations, and ethnographic interviewing of NPS and community affiliates to derive applied strategies for cemetery repair, operational efficacy, and this specific, public lands “co-management” relationship. With data from 12 interviews, eight participant observations, and six condition assessment surveys, it’s argued that perceptions …

Affective Teacher Tok: A Sociomaterial Analysis Of Teachers’ Digital Literacy Practices On Social Media., Jessica Nicole Gottbrath

Electronic Theses and Dissertations

Mass media often depicts teachers in oversimplified terms, as heroic saviors or dangerous agents of indoctrination, flattening the complex realities of their daily work and lived experiences. This polarization contributes to the ongoing deprofessionalization of teaching, where educators’ expertise is increasingly questioned and politicized. In response to these reductive portrayals and the everyday pressures of the profession, some teachers have turned to short-form social media videos as a creative outlet to share personal and professional insights. To explore how teachers reclaim agency through their digital literacy practices, this study employs mixed-methods research to investigate how educators use networked microvideos to …

The Ten Commandments Goes Hollywood: A Century's Film Adaptations Of The Moses Narrative As Reflections Of American Culture., Aaron Nusz

Electronic Theses and Dissertations

This dissertation examines the various film adaptions that the American Hollywood has released about the Biblical character Moses. The scope of this examination is limited to theatrical releases from Hollywood in English, which spans roughly 100 years of history. Each of the five films examined in this dissertation represents a different period in American culture, and all are from a different film genre. Starting with The Ten Commandments (1923) which represents the silent-film era of Hollywood, to the 2014 blockbuster Exodus: Gods and Kings, the film industry has continued to produced films which examine the life and deeds of Moses …

Black Women Under The White Gaze: Resistance From Enslavement To Incarceration And Reentry., Barbie C. Parker

Electronic Theses and Dissertations

Black women in the United States who are currently incarcerated or have previously served time in prison have a particular need for protection as they move through the criminal “injustice” system because they frequently act as the primary caregivers for their families. Consequently, Black female convicts have historically had to create their social networks inside and outside carceral spaces as a form of resistance to white supremacist ideologies and as a site of protection. By highlighting Black women’s history of enslavement and incarceration, the different forms of resistance, and centering their narratives, we can paint a more complex picture of …