Digital Commons Network^™

A Trauma-Informed School-Based Mental Health Counseling Intervention To Promote The Social-Emotional And Academic Functionality Of Children Living In Poverty, Mary Perleoni

Electronic Theses and Dissertations

The purpose of this study was to investigate the effectiveness of a trauma-informed school-based mental health counseling intervention (TI-SBMHCI) on students enrolled in three Title I elementary schools. This study aimed to examine the impact of a TI-SBMHCI on participants' social-emotional functionality, trauma symptomology, and academic behavior. Counselors-in-training provided a 10-week TI-SBMHCI based off of Bath's (2008) The three Pillars of Trauma-informed Care and data was collected at pretest (first session), mid (fifth session), and posttest (tenth session). In addition, this investigation examined if participants showed greater improvement in academic behavior in comparison to students who did not receive a …

Magnesium-Based Treatment For The Degradation Of Octachlorodibenzofuran And Trinitrotoluene, Amal Mogharbel

Electronic Theses and Dissertations

The aim of the present research is to investigate the efficacy of using ball-milled zero-valent magnesium (ZVMg) with and without activated carbon (AC) for the dechlorination of polychlorinated dibenzofurans. Three different solvent systems are presented here which are ethanol, ethanol/ethyl lactate (90:10), and 2-butoxyethanol. These solvents in combination with ZVMg with and without activated carbon were tested towards the degradation of octachlorodibenzofuran (OCDF, the most highly chlorinated PCDF congener). All the tested systems were very powerful and reductively dechlorinated OCDF to less chlorinated congeners. However, the system of ball-milled ZVMg and ethanol was the only system which converted OCDF and …

A Child Shall Lead Them: Exploring Discourses Of Efficacy And Climate Change As They Appear In Children's Animated Film, Jason Derry

Electronic Theses and Dissertations

Recent climate change discourse has tended to presume scientific knowledge and rational argumentation as the principle factor in convincing peoples and publics toward climate action. However, scholarship across numerous fields reveals myriad other contributing factors in how people think about and respond to this environmental crisis, which leans predominately toward silence and apathy. Alongside this, children are often centered as inheriting a calamity, yet find themselves largely disempowered. From out of this rhetorical milieu I interject by way of a multidisciplinary grounding to examine the predominate framings of efficacy in the context of children, climate change, and environmental discourse. To …

Is A Picture Worth A Thousand Numbers? An Exploration Of Understanding And Recall Of Data Presentations, Holly L. Roof

Electronic Theses and Dissertations

This dissertation reports results of a study with a quasi-randomized experimental component and a protocol analysis, or think aloud, component. The experimental component was designed to determine if people with no statistical training and people with some statistical training differed in their understanding and recollection of statistical information with varying degrees of complexity. Information was presented using data visualization techniques based on cognitive theory and compared to presentations using APA-style numerical tables of statistical output. The focus was on using empirically-supported graphical displays in PowerPoint presentations such as one might see at a research conference. Classroom groups of beginning and …

Side-To-Side Comparison Of Total Shoulder Arthroplasty And Intact Function In Individuals, Sarah Rose Walden

Electronic Theses and Dissertations

Total Shoulder Arthroplasty (TSA) is a surgery which replaces the shoulder joint, or the interface between the humerus and the scapula glenoid. To test TSA success, most prior research compares patients with TSA to healthy controls. However, the shoulder anthropometry, motion, and musculature of individuals varies widely across the population making it important to assess TSA performance in individuals. The overall goal of this study is to determine if patients with one of two TSA implant designs on one side achieve the same range of motion as their intact side, and if so to find if they compensate using increased …

A Disability Theology Of Limits For Responding To Moral Injury, Lisa Hickman

Electronic Theses and Dissertations

The lament of Jeremiah, “they dress the wound of my people as if it were not serious,” reverberates today as veterans return home from a decade of war, ridden by PTSD and moral injury, only to discover lethargy, lack of seriousness and complacency in societal response. The seriousness of our soldiers’ wounds, to body and spirit alike, demand ethical, societal and theological responsibility. Failure to address the seriousness of these wounds results in distress, depression and even suicide for the soldier. Statistics may describe a portion of the reality, but the degree to which soldiers suffer in silence and the …

Harnessing The Anopheles Microbiome To Conditionally Express Anti-Plasmodial Effectors During The Blood Meal, Jackie Shane

Electronic Theses and Dissertations

The control of vector-borne diseases such as malaria has been an extremely important research subject for hundreds of years. Because of the complex lifecycles of the pathogens that cause these diseases, finding a comprehensive treatment or preventative strategy has proven extremely difficult. Malaria alone is responsible for almost half a million deaths annually, most of them children under 5 years old. This disease is caused by parasitic protists in the genus Plasmodium that are transmitted to humans from Anopheles sp. mosquitoes. Most preventative strategies that are in use today revolve around controlling the vectors, including bed nets, insecticides, and larval …

Non-Symbolic Exact Quantity Representation In A Language-Impaired Population, John Verbos

Electronic Theses and Dissertations

The linguistic relativity hypothesis argues that language influences non-linguistic cognition. One version of the hypothesis suggests that language is a set of tools or technologies that variously enhance or dampen an individual’s capacity to perceive and operate upon the world in certain ways. A domain in which this may be tested is number, where it is hypothesized that counting language allows us to bridge our innate capacities for recognizing small exact quantities (subitizing) and approximating quantities larger than three or four (analog magnitude estimation). To test this, previous studies have asked adult participants who have limited or no access to …

Characterization Of G-Protein Coupled Receptors In Pain, Depression And Anxiety, Neil Lax

Electronic Theses and Dissertations

Chronic pain and major depressive disorder are widespread conditions in the world. Interestingly, these conditions often occur comorbidly, with each individual disease amplifying the symptoms of the other. A significant amount of preclinical research in pain and depression focuses on G-protein coupled receptors (GPCRs), implying that GPCRs may be useful in treating this comorbidity. Our efforts have sought to characterize several poorly understood GPCRs, including the serotonin receptor subtypes 2C and 7 (5-HT2CR and 5-HT7R) and metabotropic glutamate receptor 5 (mGluR5), along with more well-known GPCRs such as the mu opioid receptor (MOR), and the role that they play in …

The Influence Of Age, Gender, And Thiol Repletion In An In Vivo Model Of Lewy Body Disorders, Daniel Mason

Electronic Theses and Dissertations

Lewy body disorders are a family of neurological brain disorders associated with olfactory, motor, and cognitive deficits and are collectively defined as α-synucleinopathies, as they are characterized by hallmark “Lewy bodies” composed of aggregated, fibrillar α-synuclein. It is not certain but often posited that fibrillar α-synuclein seeds the progressive, self-propagating spread of Lewy pathology through neuroanatomical circuitry. Furthermore, the site of disease induction is still debated. In Aim I, we developed a novel protocol for generating reproducible and robust α-synucleinopathy in the limbic temporal lobe following infusions of preformed α-synuclein iv fibrils into the mouse olfactory bulb, which is frequently …

Identity Negotiation, Saudi Women, And The Impact Of The 2011 Royal Decree: An Investigation Of The Cultural, Religious, And Societal Shifts Among Women In The Saudi Arabian Public Sphere, Maha Alshoaibi

Electronic Theses and Dissertations

Historically, Saudi Arabian culture has been deeply rooted in tradition, religious customs, family-oriented structures, and gender derived expectations for men and women alike. Saudi Arabian culture emphasizes a patriarchal family structure where men financially provide for their family whereas women are expected to manage internal household duties such as raising children, upholding household affairs, and working within a limited scope of employment. The concept of Saudi Arabian women integrating into the public workforce has been a source of contention and debate for the last several hundred years. Due to recent changes in political and economic events, a royal decree issued …

Four Phases Of Subjectivity: A Rhetorical And Phenomenological Analysis Of Aimé Césaire And Cahier D’Un Retour Au Pays Natal, Chelsea Binnie

Electronic Theses and Dissertations

This dissertation project sets out to perform a rhetorical and phenomenological analysis of the subjectivity that Césaire portrays in his epic poem Cahier d’un retour au pays natal, or Notebook of a Return to My Native Land. Césaire published and republished Cahier four times in a 17-year period and the modified accounts of subjectivity presented in the lines of the poem mirrors that of Césaire’s own human subjectivity. Césaire poetically unleashes Cahier and his Négritude project in an effort to shift the geography of reason from its self-appointed European center, to create a liminal space for the totalized …

Beyond Enlightenment: The Evolution Of Agency And The Modularity Of The Mind In A Post-Darwinian World, Derek Elliott

Electronic Theses and Dissertations

Working out of the social and philosophical revolutions from the Enlightenment, contemporary action theory has unwittingly inherited several Cartesian ideas regarding the human mind: that it is unified, rational, and transparent. As a result, we have for too long conceived of action as intimately bound up with reason such that to act at all is to act for a reason, leaving us with theoretical difficulties in accounting for the behavior of non-human animals as well as irrational behavior in human beings.

But rather than propose that such difficulties can be resolved by retreating to a pre-Enlightenment view of human nature, …

Externality In Hegel's Philosophy Of Nature, Martin Krahn

Electronic Theses and Dissertations

The topic of my dissertation is the metaphysics of laws of nature in Hegel’s philosophy of nature. I argue that Hegel differentiates laws of nature from norms of culture through a concept of “externality,” according to which the universals or laws of nature stand outside of, apart from, independent from their particulars. He contrasts this with norms of culture, where the universals are internal to the particulars, such that in culture the particular events or actions shape the norms, whereas in nature, the laws remain the same through their independence from the particular events. I then address the consequences this …

Pyrrolo[2,3-D]Pyrimidine Classical Antifolates For Targeted Cancer Chemotherapy- Applications Of Bioisosteric And Regioisomeric Substitutions For Improved Tumor-Selectivity And Potency, Manasa Punaha Ravindra

Electronic Theses and Dissertations

In 2018, it is estimated that 1,735,350 new cases of cancer and 609,640 deaths from the disease will be diagnosed in the United States alone. Conventional chemotherapy is by far the most successful category of clinical oncology, having cured (complete remission (CR), without return) or provided clinical benefit to millions of people. However, since its earliest discovery, the major causes of failure of conventional cancer chemotherapy have been dose-limiting toxicities and development of resistance. There is a desperate ongoing search for new cancer therapies as tumor-targeted agents (without harming normal cells or tissues) with low propensity for the development of …

Camp Geronimo: Evaluating The Influence Of An Animal Assisted Intervention Based Summer Camp On Social Participation In Children With Intellectual And Developmental Disabilities, Joelle Ruggeri

Electronic Theses and Dissertations

Research regarding animal assisted intervention (AAI) has found that it can be an effective intervention towards promoting positive social participation in children with intellectual and developmental disabilities (IDD). A quality improvement project was implemented at The Barn at Spring Brook Farm, where children ages 2-12 with IDD are able to participate in AAI activities. The purpose of this project was to evaluate the Barn’s Camp Geronimo, a six-week long summer camp program, and its impact on the social participation of participants using the Home & Community Social Behavior Scales (HCSBS). The study findings showed positive results, with statistically significant change …

Corporate Social Responsibility To-Come: A Derridean Interruption Of Transparency, Robert Foschia

Electronic Theses and Dissertations

This study investigated the relation between rhetorics of transparency and organizational action. Digging into CSR literature from a philosophy of communication perspective, this project seeks to determine if corporate social responsibility delivers on the promises it makes of a better world.

Drawing on the work of Jacques Derrida, the research first lays out his often overlooked contribution to the philosophy of communication, and then moves towards possible applications in deconstructing the perceived benefits of CSR, particularly in its transparent nature. By looking at organizational life from the Triple Bottom Line, this dissertation peels back the underlying rhetoric of planet, people, …

Anxiety, A Growing Social Problem: A Systematic Review Of The Literature, Adela Robinson

Electronic Theses and Dissertations

Anxiety disorders as a stand-alone diagnosis are not recognized as a treatable mental health issue within the social services mental health realm. There are mixed results regarding if anxiety disorders are linked to suicide ideation and suicide attempts. The aim of this systematic review was to discover if there is a link between anxiety disorders and suicide ideation and suicide attempts within the current literature. All anxiety disorders were looked at, except for selective mutism and separation anxiety disorder due to these both typically only affecting those in very young childhood. The rest of the anxiety disorders affect those from …

The Rhetoric Of Missions Reporting, Bailey Cate

Electronic Theses and Dissertations

Missions, especially short-term trips, are becoming more and more controversial. As short-term missionaries interact in the field, they take pictures depicting the poverty, lack of resources, and overall sense of destitution around them. These photos have helped generate income, as many Christians who see the photos as part of updates on mission work they supported come to see themselves in a position of “savior” because they have resources to give to “those in need.” Evangelism is a critical component of Christianity; however, how people evangelize and how they communicate about that evangelism is equally critical. By analyzing both the church …

The Role Of Cathelicidin In The Regulation Of Gut Microbiota And Inflammasome Activation In Alcoholic Liver Disease., Fengyuan Li

Electronic Theses and Dissertations

Alcoholic liver disease (ALD) is characterized by gut dysbiosis and hepatic and intestinal inflammation. Gut microbiota is critically maintained by antimicrobial peptides (AMPs) expressed in the epithelial and immune cells. AMPs are also identified as immune-regulators in various diseases. Previous studies demonstrated that deficiency of AMPs REG3 lectins exacerbated alcoholic steatohepatitis. LL-37 is the sole member of human cathelicidin AMP family, named CRAMP in mouse. Despite of the extensive studies in infectious diseases and in gut-microbiota-related inflammatory bowel disease, the role of LL-37/CRAMP in ALD is yet unknown. Our previous studies showed a decreased intestinal CRAMP in a mouse model …

Characterizing The Gut Microbiota During Plasmodium Infection And Antimalarial Treatment., Joshua E. Denny

Electronic Theses and Dissertations

Plasmodium, the parasitic cause of malaria, is a global pathogen, annually causing 216 million infections and 445,000 deaths. As drug resistance continues develop and no effective vaccine is available, it is critical to understand the factors underlying the severity of this disease. Plasmodium is an extra-gastrointestinal tract infection where the parasite infects red blood cells causing clinical malaria. However, recent publications have pointed to interactions between the gut microbiota and malaria. With this in mind, the role of the gut microbiota in malaria infection was studied. C57BL/6 mice from different vendors displayed differential resistance and susceptibility to severe malaria, …

Common Ground, Diverging Paths: Eighteenth-Century English And French Landscape Painting., Jessica Robins Schumacher

Electronic Theses and Dissertations

In the early eighteenth century, both English and French artists traveled to Rome to study the great seventeenth-century landscape artists --Claude Lorrain and Nicolas Poussin in particular—at the source. The English were motivated by a combination of reverence for the ancient, classical world, an associative imagination and a burgeoning competitive art market. The French, by an equal regard for antiquity and the pragmatic desire to complete the requirements of the monopolistic French Academy. While English landscape painting evolved away from the idealism of Claude to a modern naturalism imbued with the artist’s subjective response to a visual experience, French landscape …

Effects Of Hydrogen Sulfide In Hyperhomocysteinemia-Mediated Skeletal Muscle Myopathy., Avisek Majumder

Electronic Theses and Dissertations

Although hyperhomocysteinemia (HHcy) occurs due to a deficiency in cystathionine-β-synthase (CBS), causing skeletal muscle myopathy, it is still unclear whether this effect is mediated through oxidative, endoplasmic reticulum (ER) stress, both or something else. Cystathionine γ-lyase (CSE) and CBS are the main H₂S producing enzymes, which produce Hydrogen sulfide (H₂S) from Hcy in the transsulfuration reaction. H₂S is an anti-oxidant compound and patients with a CBS deficiency cannot produce enough H₂S, thus rendering them vulnerable to excess Hcy-mediated damage. Both in-vitro (C2C12 cells) and in-vivo (CBS+/- mice) models were used to …

Lead And Crime: An Ecological Study Between Lead Contaminated Topsoil And Violent Crime., Brian Guinn

Electronic Theses and Dissertations

Lead is a known neurotoxicant. Human exposure to lead comes primarily through environmental exposures, including remnant lead paint, lead contaminated topsoil and lead contaminated water. Prenatal and early life lead exposure has been associated with numerous neurocognitive and neuropsychiatric disorders. This dissertation presents findings from an ecological study which evaluated the geospatial association between topsoil lead content and the incidence of FBI designated violent crime in Jefferson County, Kentucky. A total of 412 topsoil samples were collected along roadways (n=300) and from Louisville Metro Parks (n=112). Jefferson County crime data was obtained from the Louisville Metro Police Department – Crime …

Impacts Of Ammonia And Temperature On Freshwater Snail Behavior And Physiology., Megan Christine Dewhatley

Electronic Theses and Dissertations

Gastropods are one of the most imperiled groups of animals in North America, yet there are major gaps in the literature pertaining to pollutants and climate change, and especially sublethal impacts. This dissertation assesses the effects of climate warming and unionized ammonia (NH₃), one of the most abundant water pollutants, on the behavior and physiology of two caenogastropod snails: fine-ridged elimia (Elimia semicarinata) and Shawnee rocksnails (Lithasia obovata) (Gastropoda: Neotaenioglossa: Pleuroceridae). Righting behavior, or the movement used by snails to turn themselves right-side-up, was used as the main endpoint; delays in this behavior compromise …

Transcending The Panels: Varieties Of Experience And Selfhood In Comics., Will D. Simpson

Electronic Theses and Dissertations

In this dissertation, I argue that the typical formal features of American comics over the past century have influenced the types of narrative content that tend to be communicated by said medium. I argue that the types of reader experiences that are afforded by the comics form, in part, shape the types of stories told through comics. The experiences that result from the ways we engage perceptually, cognitively, emotionally, and conceptually with comics imply a certain view of selfhood that is potentially subversive in the context of American cultural religiosity and spirituality. The formal features of comics, and the resulting …

Role Of Trkb-Signaling In Taste Development And Function., Jennifer Rios-Pilier

Electronic Theses and Dissertations

In the geniculate ganglion, taste neurons likely differentiate into subtypes during development, but very little is known about how these neurons are defined molecularly or how they differentiate. Embryonically, geniculate neuron development is regulated by the growth factor, brain ­derived neurotrophic factor (BDNF). Postnatally, BDNF becomes restricted to subpopulations of taste receptor cells with specific functions, primarily sour responding. I hypothesized that during development, the receptor for BDNF, tropomyosin kinase B receptor (TrkB), also becomes restricted to a neuronal subset. I used transgenic mouse models to label and quantify both geniculate sensory neurons (Phox2b+), and those expressing TrkB (GFP) across …

Association Between Cigarette Smoking And Ovarian Reserve Among Women Seeking Fertility Treatment With Effect Modification By Race And Nat2 Genotype., Islamiat A. Oladipupo

Electronic Theses and Dissertations

Cigarette smoking in women has been associated with adverse reproductive outcomes such as reduced ovarian reserve, poorer in vitro fertilization (IVF) outcomes and increased adverse pregnancy outcomes. This study examined the association of smoking with ovarian reserve in a cross-sectional study of women seeking fertility treatment, and potential effect modification by race and NAT2 acetylator phenotype. Data from 265 women from the Louisville Tobacco Smoke, Genetic Susceptibility, and Infertility (LOUSSI) Study were analyzed. A total of 265 women were recruited through a single infertility clinic between September 2016 and June 2018. Information on current smoking status was assessed using a …

Assessing The Role Of Arsenite In Disrupting The Egfr Signaling Axis., Christine Kim

Electronic Theses and Dissertations

The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase localized on the cell surface. Overexpression of EGFR has been used as biomarkers for many different types of cancers, including lung cancer. There is a strong association between arsenic and lung cancer development, although the mechanism is unclear. We hypothesize that chronic exposure of “a physiologically relevant” level of arsenite disrupts the EGFR endocytic trafficking. The goal of this project is to identify molecular mechanisms and roles of chronic arsenite-induced EGFR overexpression in lung cancer development. A non-malignant human bronchial epithelial cell line, Beas-2B cells were exposed to 100 …

The Migration And Developmental Remodeling Of Intrinsic Interneurons In Visual Thalamus And The Role Of Retinal Signaling., Naomi E. Charalambakis

Electronic Theses and Dissertations

The dorsal lateral geniculate nucleus (dLGN) of the mouse is a model system to study the development of thalamic circuitry. While most studies focus on relay neurons of dLGN, little is known about the factors regulating the development of the other principal cell type, intrinsic interneurons. To date, the targeting and migratory path of dLGN interneurons as well as their morphological development remains unclear. Here we examined whether the migration, structure, and function of interneurons relies on retinal signaling. We took a loss-of-function approach and crossed GAD67-GFP mice, which express green fluorescent protein (GFP) in dLGN interneurons, with math5 nulls …