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Extended Adolescence: The Ecology And Endocrinology Of Facultative Paedomorphosis, Jason R. Bohenek
Extended Adolescence: The Ecology And Endocrinology Of Facultative Paedomorphosis, Jason R. Bohenek
Electronic Theses and Dissertations
Phenotypic plasticity is an adaptation to unpredictable environments whereby an organism of a single genotype may express more than one phenotype under differing environmental conditions. Phenotypic plasticity can manifest as polyphenisms, which is an extreme form of phenotypic plasticity that produces two or more discrete, alternative phenotypes. The expression of alternative phenotypes is controlled by biotic and abiotic environmental factors, which variably affect the strength and direction of phenotypic outcomes. Using a model polyphenic salamander, I sought to understand the ecological and hormonal processes that regulate alternative phenotype expression. The mole salamander (Ambystoma talpoideum) and eastern newt ( …
Allodynia And Self-Efficacy In Migraineurs, Ashley N. Polk
Allodynia And Self-Efficacy In Migraineurs, Ashley N. Polk
Electronic Theses and Dissertations
Headache disorders are among the most comdisorders of the nervous system, with migraine alone affecting 14% of women and 6% of men worldwide each year. Headache-related self-efficacy, or one’s confidence in preventing and managing headache, is particularly important for prevention and management of headache disorders and predicts response to behavioral and pharmacological treatments. Allodynia, the perception of non-noxious stimuli as painful due to central sensitization, compounds headache-related disability and compromises efficacy of triptans. Therefore, migraineurs with allodynia may perceive headache treatments as less efficacious and thus have reduced perceived headache-related self-efficacy. However, no literature to date has explored the relationship …
Patient Empowerment In Modern Medicine: A Personal Account Of Endometriosis And Being An Equal Partner In My Healthcare, Jacqueline Schlick
Patient Empowerment In Modern Medicine: A Personal Account Of Endometriosis And Being An Equal Partner In My Healthcare, Jacqueline Schlick
Electronic Theses and Dissertations
This work outlines my personal experience with a diagnosis of stage three endometriosis and partial oophorectomy surgery along with the subsequent medical opinions I received by my primary OB/GYN and other doctors. This thesis seeks to discuss the issues surrounding patient empowerment, and specifically, laws that support patients in their exploration of the truths behind their conditions and the importance of self-education in order to be better equipped in conversations with their physicians. The work includes testimonials from women about their levels of knowledge into their own medical needs upon the time of their prescription to pharmaceutical medications, and how …
Variations In The Dragonfly Microbiome Through Life Stages And Its Ability To Harbor Antibiotic Resistant Bacteria, Sarah Russell
Variations In The Dragonfly Microbiome Through Life Stages And Its Ability To Harbor Antibiotic Resistant Bacteria, Sarah Russell
Electronic Theses and Dissertations
Juvenile dragonflies (nymphs) may possess the ability to pass their microbiome to the adult life stage through metamorphosis. If this is so, the environment in which the nymph develops may have an effect on the adult microbiome. In this study, the gut microbiomes of 13 species of dragonfly were compared across life stages and when collected from environments at different levels of urbanization. The gut of each dragonfly was removed, DNA extracted, and a portion of the bacterial 16S rRNA gene amplified and sequenced. Gut suspensions were also plated on antibiotic amended plates to determine the potential for dragonflies to …
Minimum Number Of Individuals: A Methodological Comparison Using Human Remains From Caves Branch Rockshelter In The Cayo District Of Belize, Caitlin Elizabeth Stewart
Minimum Number Of Individuals: A Methodological Comparison Using Human Remains From Caves Branch Rockshelter In The Cayo District Of Belize, Caitlin Elizabeth Stewart
Electronic Theses and Dissertations
The analysis of human remains in archaeological contexts is often complicated by the presence of highly fragmented and commingled remains. The standard methods used to help quantify the number of individuals and elements in these contexts are based upon the segmentation of whole bones. The methods provide standardization and are flexible enough to allow for the idiosyncratic nature of each context. However, this results in a lack of transparency, which is necessary to reanalyze the same sample or to compare “like” contexts, as the data collected will vary.
Formulation Development, Preclinical Testing, And Primary Packaging Optimization For Cannabinoids And Other Therapeutics, Pranjal Taskar
Formulation Development, Preclinical Testing, And Primary Packaging Optimization For Cannabinoids And Other Therapeutics, Pranjal Taskar
Electronic Theses and Dissertations
Through the process of drug development, a molecule goes through discovery screening; lead selection and optimization, ADME testing, toxicity profiling, dosage form determination, preclinical testing in an in vitro and in vivo setup, folloby clinical research, FDA review and approval until eventually it is manufactured in the determined dosage form and reaches the patient. At every point through this process, scientists actively work towards a smoother transition and a quick and safe approval of the molecule towards the next step. The different chapters in this research would cover various phases of drug development; from discovery stage to fill-finish and primary …
Bacterioplankton Biogeography Of The Mississippi River Basin, Jason Taylor Payne
Bacterioplankton Biogeography Of The Mississippi River Basin, Jason Taylor Payne
Electronic Theses and Dissertations
Bacterioplankton are important structural and functional components of river networks yet their biogeographical patterns in these systems are largely unknown. Using Illumina sequencing of the 16S rRNA gene we characterized variation in bacterioplankton community alpha diversity (within-sample richness of operational taxonomic units OTUs) and beta diversity (between-sample differences in composition) (1) along a 1 300-km downstream reach of the Mississippi River (2) over a range of temporal scales in the Lower Mississippi River (LMR) and (3) along cross-sectional transects repeated monthly for six months across the LMR floodplain. Particle-associated assemblages were richer in bacterial OTUs and more productive than free-living …
Reward And Punishment: The Neural Correlates Of Reinforcement Feedback During Motor Learning, Christopher Mark Hill
Reward And Punishment: The Neural Correlates Of Reinforcement Feedback During Motor Learning, Christopher Mark Hill
Electronic Theses and Dissertations
‘By the carrot or the stick’ reward or punishment has been contemplated by instructors to motivate their pupils to learn a new motor skill. The reinforcements of reward and punishment have demonstrated dissociable effects on motor learning with punishment enhancing the learning rate and reward increasing retention of the motor task. However it is still unclear how the brain processes reward and punishment during motor learning. This study sought to investigate the role of reinforcement feedback in cortical neural activity associated with motor learning. A novel visuomotor rotation task was employed with reward punishment or null feedback as the participants …
Synthesis Of A Novel Surface Active, Light Sensitive Polymer For Encapsulation And Delivery Of Paclitaxel, Amit Raviraj Pillai
Synthesis Of A Novel Surface Active, Light Sensitive Polymer For Encapsulation And Delivery Of Paclitaxel, Amit Raviraj Pillai
Electronic Theses and Dissertations
Melanoma and non-melanoma (basal cell and squamous cell carcinoma) skin cancer (NMSC) have been recognized as an epidemic as they happen to be the most comtype of cancers in the white population. Cancer cell targeting i.e. differentiating cancer cells from normal cells has been an area of active research to reduce the side effects of cancer chemotherapy. For this research project, we have developed a novel light sensitive Methylene Blue (MB)-Polyethylene glycol (PEG) conjugate with significant surfactant properties. The aim of this study was to synthesize a smart light sensitive polymer which activates and releases the encapsulated drug on exposure …
Description And Alleviation Of The Stress Response In Atlantic Sharpnose Sharks (Rhizoprionodon Terraenovae), White-Spotted Bamboo Sharks (Chiloscyllium Plagiosum), And Golden Shiners (Notemigonus Crysoleucas), Lauren Nicole Fuller
Electronic Theses and Dissertations
Sharks are an essential component of many marine ecosystems; however they have experienced population declines mainly attributed to overfishing and capture of sharks as bycatch. Despite sharks often being released when captured as bycatch the act of capture can result in a stress response which may cause severe physiological perturbations. Studies have investigated the physiological impacts of capture stress on elasmobranchs but most have primarily focused on the secondary stress response. I conducted a series of studies to further describe the primary stress response through quantification of adrenocorticotropic hormone (ACTH) while also investigating methods such as sedation and limiting air …
Doing Hard Things In The Context Of Values: Values Intervention As An Establishing Operation For Approach Behavior In The Presence Of Aversive Stimuli, Emmie Hebert
Electronic Theses and Dissertations
Aversive control is an umbrella term for behavioral contingencies influenced by the removal or avoidance of aversive stimuli. When individuals are engaging in behavior that is under aversive control the behavior becomes relatively insensitive to changes in the environment outside of trying to escape or avoid the aversive stimulation. Teaching individuals to increase behavioral and psychological flexibility around potentially aversive stimuli is a goal of a therapeutic perspective called Acceptance and Commitment Therapy (ACT). ACT therapists and trainers use values to motivate their clients to engage in meaningful behaviors despite ever-changing and often aversive contexts. The aim of the current …
How Ghost Stories Shape The State Of Mississippi And The People, Ana Lauren Martinez
How Ghost Stories Shape The State Of Mississippi And The People, Ana Lauren Martinez
Electronic Theses and Dissertations
Many people chose to brush off the stories and when asked about them they would skip around the story to talk about the history of a place. Those who embraced the stories were not only knowledgable about the stories but also the history. They tended to give both sides with equal enthusiasm and seriousness. Over the years Mississippians have learned about their neighbors through the stories that they told around the campfire or at sleepovers. These stories have been passed down from one generation to the next and have a way of not only identifying a place but also a …
Teaching Kids To Say "Ew!": Parent-Child Disgust Transmission, Brooklee Lightsey Tynes
Teaching Kids To Say "Ew!": Parent-Child Disgust Transmission, Brooklee Lightsey Tynes
Electronic Theses and Dissertations
Disgust is one of the six basic emotions but research suggests it is far more complex. As individuals respond to stimuli in different manners this suggests the emotion and its development may be shaped through learning principles and cultural practices (Rozin Lowery & Ebert 1994). It is imperative to understand how children’s disgust responses are shaped though observation classical and operant conditioning demonstrated by their primary caregivers. The current study examined the transmission of the emotion of disgust from primary caregivers to their children. Participants were 17 children (55.6% female) and one of their parents in Mississippi and Nebraska. The …
Comparative Assessment Of Safety And Quality Of Tinospora Species-Tinospora Crispa And Tinospora Sinensis, Abidah Parveen
Comparative Assessment Of Safety And Quality Of Tinospora Species-Tinospora Crispa And Tinospora Sinensis, Abidah Parveen
Electronic Theses and Dissertations
Tinospora crispa Miers ex Hook.f. & Thomson and Tinospora sinensis (Lour.) Merr. (Menispermaceae) are two species that have morphological similarities which makes distinction between the two of critical importance because T. crispa has been reported to cause hepatotoxicity. Comparative morpho-anatomy of the leaves and stems of Tinospora species indigenous to south and southeast Asia was undertaken to elaborate their distinguishing pharmacognostic features. Chemical characterization of the secondary metabolites of the two species may aid in elucidating their chemical diversity and hence help to resolve safety and quality issues. Phytochemical investigation of the stems led to the isolation of nineteen compounds …
Factors Related To Obsessive-Compulsive Symptoms: Understanding The Contribution Of Disgust, Contamination Fear And Emotion Regulation, Alexandra Gilbert
Factors Related To Obsessive-Compulsive Symptoms: Understanding The Contribution Of Disgust, Contamination Fear And Emotion Regulation, Alexandra Gilbert
Electronic Theses and Dissertations
The current study included 149 students from the University of Mississippi as apart of an archival dataset from a larger lab study. Results from the primary analyses indicate that all variables of interest (i.e. contamination fear, disgust sensitivity, and emotion regulation) were significantly correlated with OC symptoms. However, despite disgust’s associations with OC symptoms, results from regression analysis suggest that neither general disgust nor individual domains of disgust were predictive of contamination-based OC symptoms above and beyond contamination fear. Results from the hierarchical regression analysis emphasize the prominent role that contamination fear has on contamination-based OC symptoms. Further, sex differences …
Unraveling Anticancer Activity And Pharmacokinetics Of Dihydroartemisinin Dimer Oxime, Lu Dai
Unraveling Anticancer Activity And Pharmacokinetics Of Dihydroartemisinin Dimer Oxime, Lu Dai
Electronic Theses and Dissertations
Artemisinin is currently used as an antimalaria drug. Studies have shown its monomeric form exhibited promising anticancer effects by inhibiting the proliferation, inducing apoptosis, and increasing oxidative stress of tumor cells. Recently, several dimeric forms of artemisinin have been synthesized with more potent anticancer activity. In this study, nine dihydroartemisinin dimers with diversely functionalized linkers exhibited similar cytotoxicity against human breast adenocarcinoma MDA-MB-231 in vitro. Among these nine DHA dimers, DHA dimer oxime was selected for further anticancer activity and pharmacokinetic study. Our preliminary study shothat DHA dimer oxime displayed more than a 10-fold increase of antiproliferation effect over its …
Behavioral Similarities And Differences Among Symptoms Of Emetophobia, Disordered Eating, And Disgust, Jennifer Arden Petell
Behavioral Similarities And Differences Among Symptoms Of Emetophobia, Disordered Eating, And Disgust, Jennifer Arden Petell
Electronic Theses and Dissertations
Emetophobia, also known as the specific phobia of vomiting (SPOV), is a clinical disorder with severe symptomatology and chronicity. However, there remains a significant lack of knowledge in overall conceptualization and etiological understanding. Recent literature has described this disorder within the context of abnormal eating disorders, despite the essential difference in symptom function between SPOV and disordered eating (Keyes & Veale, 2018; Volpe et al., 2015). Therefore, the present study sought to further the conceptualization and delineation of symptoms of emetophobia and disordered eating, as well as their potential relation with disgust. More specifically, it was hypothesized that symptoms of …
Civic Engagement Among Emerging Adults: Self-Efficacy, Purpose, And Program Experiences, Rachel Marsh
Civic Engagement Among Emerging Adults: Self-Efficacy, Purpose, And Program Experiences, Rachel Marsh
Electronic Theses and Dissertations
Understanding how to cultivate civic mindedness and engagement in emerging adults is of central importance. Theories of positive youth development point to the importance of particular youth characteristics for promoting the development of successful and contributing citizens (Lerner, Almerigi, Theokas, & Lerner, 2005). Among these, self-efficacy, or one’s belief in their ability to perform a specific task, is considered essential (Bandura, 1977; DeWitz, 2004; Solhaug, 2006). Scholars have, more recently, pointed to the role of purpose as key for motivating civic engagement (Damon, Menon, & Cotton Bronk, 2003). Beyond youth characteristics, other scholars point to the importance of opportunities for …
The Effects Of Differing Optical Stimuli On Depth Perception In Virtual Reality, Mckennon B. Mcmillian
The Effects Of Differing Optical Stimuli On Depth Perception In Virtual Reality, Mckennon B. Mcmillian
Electronic Theses and Dissertations
It is well documented that egocentric depth perception is underestimated in virtual reality more often than not. Many studies have been done to try and understand why this underestimation happens and what variables affect it. While this underestimation can be shown consistently the degree of underestimation can strongly differ from study to study, with as much as 68% to as low as 6% underestimation, Jones et al. (2011, 2008); Knapp(1999); Richardson and Waller (2007). Many of these same studies use blind walking as a tool to measure depth perception. With no standardized blind walking method for virtual reality existing differing …
Application And Refinement Of Molecular Ecology Techniques For Amphibian Conservation, Stephanie Marie Burgess
Application And Refinement Of Molecular Ecology Techniques For Amphibian Conservation, Stephanie Marie Burgess
Electronic Theses and Dissertations
Wildlife conservation has become increasingly difficult due to habitat loss habitat fragmentation and land use change. Thus conservationists have embraced advances in molecular ecology such as landscape genetics and microbial bioinformatics that employ genetic techniques to further understand the relationship between individuals and their environment. In landscape genetics model inferences can be used to identify features that facilitate or resist gene flow providing a framework for anticipating the impacts of land use changes on a species’ ability to disperse. However the factors that affect the transferability of landscape genetics inferences are poorly understood and little is known about the effect …
The Influence Of Site Connectivity On Zooplankton Assemblage Dynamics Within The Lower Mississippi River Floodplain, Jarrod Sackreiter
The Influence Of Site Connectivity On Zooplankton Assemblage Dynamics Within The Lower Mississippi River Floodplain, Jarrod Sackreiter
Electronic Theses and Dissertations
Zooplankton are important components of the food web of such lotic systems. Although capable of motility, they are weak swimmers and their distribution and community composition across a floodplain is strongly affected by patterns of water flow and hydrologic connectivity. However, there has been little research on the zooplankton dynamics of large rivers, such as the Lower Mississippi River (LMR). From morphological identification of zooplankton across the connectivity gradient, I assessed the degree to which hydrologic connectivity acts as an explanatory factor influencing spatial and temporal variation in zooplankton assemblage structure. Second, I compared the use of morphological identification to …
Decoding And Optimizing Magnesium Phosphate Binders For Additive Construction Applications, Hashem Khaled Almashaqbeh
Decoding And Optimizing Magnesium Phosphate Binders For Additive Construction Applications, Hashem Khaled Almashaqbeh
Electronic Theses and Dissertations
This work aims to give more insight about the physical, mechanical, thermal, and chemical performance of the MPC paste composites. Our primary outcome from this research is to improve the MPC composites with different additives, including boric acid, GnP, and acetic acid for potential utilization in 3DcP applications. Furthermore, Martian and Lunar regolith simulants can be mixed with the MPC composites to create mortars as a possible extraterrestrial 3DP in-situ construction material mainly to support the NASA habitation exploration mission.
Disturbing The Ecological Pastoral: An Examination Of Willa Cather's Fictional Spaces In My Ántonia And Death Comes For The Archbishop, Anne Carter Stowe
Disturbing The Ecological Pastoral: An Examination Of Willa Cather's Fictional Spaces In My Ántonia And Death Comes For The Archbishop, Anne Carter Stowe
Electronic Theses and Dissertations
Willa Cather is universally lauded for her ability to render landscape into prose. Critics have observed for years that the landscape often functions as the main character in her fiction, or that her characters can easily be evaluated in terms of how deep and successful their relationships to the land are. In an attempt to evaluate Cather’s treatment of two different “Western” landscapes, I will focus first on My Ántonia, one of her most famous Nebraska novels, and second on Death Comes for the Archbishop, whose narrative unravels on the New Mexican landscape. I argue that Cather treats …
Design Of Thermosensitive Hydrogel For Extended-Release Of Praziquantel, Sheng Feng
Design Of Thermosensitive Hydrogel For Extended-Release Of Praziquantel, Sheng Feng
Electronic Theses and Dissertations
Parasitic diseases are a severe threat to people and animals. Praziquantel is the most comanti-parasitic drug with high efficiency, and it has been used to treat parasitic diseases for many years. However, it has very strong gastrointestinal and liver metabolism that leads to a strong first-pass effect and a short half-life. Additionally, the frequent oral administration was inconvenient for the large livestock. To overcome these drawbacks, this study aimed to develop an extended-release thermosensitive hydrogel formulation that was applicable to the injectable administration. The praziquantel-loaded hydrogel formulation based on poloxamer 407 (20%, w/v) was prepared, and two strategies for modifications …
Of Mules And Mamas: Four Women, Africana Mothering, And Resistance, Ebony Olivia Lumumba
Of Mules And Mamas: Four Women, Africana Mothering, And Resistance, Ebony Olivia Lumumba
Electronic Theses and Dissertations
The black woman’s humanity is unjustly linked to domestic responsibility and, thus, the traditional constraints of mothering. The roles of the mother and the created archetype of the mammy often become marred with the latter role overtaking the former—leaving black children without full benefit and access to their biological maternal parent. With the pervasive threat to black lives present in spaces all over the globe, for women of the African Diaspora, simply deciding to accept the role of a mother to a life that is physically, socially, and economically under siege is revolutionary. Considering this, the act of mothering, especially …
Expression Of Tumor Necrosis Factor-Alpha In A Chick Model Of Stress Vulnerable, Treatment – Resistant Depression, Mary Katherine Jourdan
Expression Of Tumor Necrosis Factor-Alpha In A Chick Model Of Stress Vulnerable, Treatment – Resistant Depression, Mary Katherine Jourdan
Electronic Theses and Dissertations
An increasing body of literature suggests a Major Depressive Disorder subpopulation, Treatment Resistant Depression (TRD), is associated with an increased immune response. More than a decade of research has identified and begun to validate a novel animal model of TRD. This study sought to determine whether TNF-α levels would be altered due to isolation stress and differentiated between stress-vulnerable and -resilient strains. Black Australorp and Production Red chicks were placed into isolation for varying times during which Distress Vocalization (dVoc) rates were calculated and transformed into entry into behavioral despair percent thresholds. Blood levels of TNF- α were quantified via …
Telephone-Delivered Cognitive Behavioral Therapy For Insomnia In Patients With Cancer: A Randomized Controlled Trial, Andel Nicasio
Telephone-Delivered Cognitive Behavioral Therapy For Insomnia In Patients With Cancer: A Randomized Controlled Trial, Andel Nicasio
Electronic Theses and Dissertations
This study examined the efficacy and feasibility of a brief telephone-delivered CBT-I (TeleCBT-I) intervention in cancer patients compared to a control group. The study used a randomized controlled trial design. The TeleCBT-I program consisted of a brief four-week CBT-I program adapted for cancer patients. Patients completed assessment measures at pre-treatment, post-treatment and one-month follow-up. Out of 184 patients screened, 39 were randomly assigned, and 35 (TeleCBT-I, n = 19; Control, n = 16) completed pre- and post-treatment measures and were included in the analyses. Compared to control group, the TeleCBT-I group reported decreased insomnia severity symptoms (p < .014), improved sleep quality (p < .023), and reduced dysfunctional beliefs about sleep (p = .039) at post-treatment with sustained treatment effects at one-month follow-up. Sleep measures yielded large effect sizes (Hedges' g, 0.84-2.7). Although the TeleCBT-I group indicated improvements in fatigue, general functioning, physical well-being, functional well-being, and physical quality of life, effects at follow-up were observed only for fatigue, functional well-being and physical quality of life. No effects were found on depression at any of the time points. In terms of feasibility, TeleCBT-I demonstrated high adherence, high homework completion and high overall satisfaction. These results advance the empirical evidence of CBT-I in cancer patients and support the use of telephone-delivered CBT-I to widely disseminate and implement among patients with cancer.
Unraveling The Role Of Phenylethanolamine N-Methyltransferase (Pnmt+) Cells In-Vivo, Sanjana Manja
Unraveling The Role Of Phenylethanolamine N-Methyltransferase (Pnmt+) Cells In-Vivo, Sanjana Manja
Electronic Theses and Dissertations
Phenylethanolamine N-methyltransferase (Pnmt) is the enzyme that N-methylates norepinephrine to produce the stress hormone/neurotransmitter, epinephrine, which is abundantly expressed in adrenal glands. Developmental studies have also identified Pnmt expression in the embryonic heart and several areas of the brain, including brainstem, cerebellum, and hypothalamus. Thus, we hypothesize that selective ablation of Pnmt+ cells will have detrimental effects on cardiovascular, neuromuscular, and metabolic processes. To uncover the importance of Pnmt+ cells in vivo, we generated a novel Diphtheria Toxin A (DTA) suicide model (Pnmt+/Cre; R26+/DTA) to selectively ablate Pnmt-expressing (Pnmt+) cells in mice. Appearing normal at birth, Pnmt-Cre/DTA mice began to …
Ab Toxins: Recovery From Intoxication And Relative Potencies, Patrick Cherubin
Ab Toxins: Recovery From Intoxication And Relative Potencies, Patrick Cherubin
Electronic Theses and Dissertations
AB-type protein toxins have a catalytic A subunit attached to a cell-binding B subunit. Ricin, Shiga toxin (Stx), exotoxin A, and diphtheria toxin are AB toxins that act within the host cytosol and kill the host cell through pathways involving the inhibition of protein synthesis. Our overall goal is to help elucidate the cellular basis of intoxication for therapeutic development. According to the current model of intoxication, the effect of AB toxins is irreversible. To test this model, we developed a system that uses flow cytometry and a fluorescent reporter to examine the cellular potency of toxins that inhibit protein …
Bone Morphogenetic Protein 7 Inhibits Pyroptotic Cell Death In Vascular Smooth Muscle Cells Of Atherosclerotic Apolipoprotein E -/- Mice, Kaley Garner
Electronic Theses and Dissertations
Atherosclerosis (ATH) is an inflammation-mediated disease in which cell death underlies the formation of lesions along the intima layer of vascular walls resulting in vessel narrowing, decreased blood flow, and increased risk of lesion rupture leading to myocardial infarction and stroke. The current study was undertaken to investigate whether inflammation in ATH can induce pyroptosis in vascular smooth muscle cells (SMC's). We therefore hypothesized that pyroptosis occurs and is inhibited by bone morphogenetic protein 7 (BMP7). We examined SMC pyroptosis at acute (D5) and midstage (D28) following disturbed flow-induced hemodynamic injury to the vascular wall using our partial left carotid …